名古屋大学大学院医学研究科 医療薬学・医学部附属病院薬剤部

医療薬学研究室紹介

研究業績

    2026年研究業績

    原著論文（欧文）

    1. Zhu Y, Kitagawa K, Mori D, Matsuzaki T, Nagai T, Nabeshima T, Takemoto-Kimura S, Ikesue H, Ozaki N, Mizoguchi H, Yamada K. Cortical excitatory and inhibitory neuron deficits may underlie the cognitive and social impairments in a mouse model of schizophrenia with exonic Reln deletion. European Journal of Pharmacology. 2026 20;1012:178469.
    2. Katsura H, Suga Y, Kimoto S, Makihara RA, Ota H, Toi H, Takata N, Ikesue H. Effectiveness of electronic patient-reported outcomes in patients with cancer undergoing immunotherapy: A real-world retrospective study. International Journal of Clinical Oncology (in press).

    2025年研究業績

    原著論文（欧文）

    1. Dong G, Mori D, Matsuzaki T, Tanaka R, Itoh N, Matsui T, Sato A, Arioka Y, Okumura H, Fukaya R, Kuba H, Nagai T, Nabeshima T, Ikesue H, Kohno K, Hattori M, Kaibuchi K, Ozaki N, Mizoguchi H, Yamada K. Twinfilin-1 phosphorylation in reelin signaling regulates actin dynamics and spine development. Pharmacological Research, 2025; 221:107986.
    2. Liu Y, Sobue A, Sahara N, Isobe M, Tanaka R, Zhu Y, Zhu W, Matsuzaki T, Yamanaka K, Yamada K, Mizoguchi H. Abnormal behaviors and glial responses in an animal model of tau pathology. Molecular Brain, 2025; Nov 6;18(1):83.
    3. Mizoguchi H, Katahira K, Inutsuka A, Kaneko R, Ono D, Hada K, Murata Y, Yasuike S, Isobe M, Kusaba M, Dong Y, Iida H, Fukumoto K, Yanagawa Y, Yamanaka A, Yamada K. Activation of orexin neurons changes reward-based decision-making strategies. PNAS Nexus,. 2025; Oct 7;4(11):pgaf322.
    4. Zhu W, Sobue A, Tanaka R, Hada K, Ibi D, Liu Y, Matsuzaki T, Nagai T, Nabeshima T, Kaibuchi K, Ozaki N, Mizoguchi H, Ikesue H, Yamada K. Acute systemic immune challenge induces cognitive impairments and anhedonia through interferon-induced transmembrane protein 3 in adult male mice. Behavioural Brain Research, 2025; 5;496:115832.
    5. Fukuzawa S, Miyagawa Y, Kawarada Y, Saeki Y, Nishijima Y, Washino Y, Mizoguchi H, Yamada K, Ikesue H. Exploring dosing of anti‑MRSA antibiotics for patients undergoing prolonged hemodiafiltration: a single‑center retrospective study. Renal Replacement Therapy, 2025; 11: 1-9.
    6. Nakai T, Tamura T, Miyagawa Y, Inagaki T, Mutsuga M, Yamada S, Yamada K, Nishiwaki K, Mizoguchi H. Population pharmacokinetic model of tranexamic acid in patients who undergo cardiac surgery with cardiopulmonary bypass. European Journal of Clinical Pharmacology, 2025; 81: 441-449.
    7. Tanigawa H, Kanatani Y, Ikesue H, Hayashi T, Yamaguchi M. Patient education to prevent exposure to anticancer drugs among patients and caregivers during outpatient chemotherapy in Japan: a cross-sectional survey. Biological & Pharmaceutical Bulletin, 2025; 48: 1972-1977.
    8. Ikemura M, Hirabatake M, Aburaya M, Ikesue H, Yasui H, Muroi N, Hashida T. Impact of diabetes on clinical outcomes in patients with incurable/unresectable and advanced/recurrent colorectal cancer receiving modified FOLFOX6 therapy. CANCER DIAGNOSIS & PROGNOSIS, 2025; 5: 42-48.
    9. Fujiwara M, Ikesue H, Yamaoka K, Uchida M, Uesawa Y, Muroi N, Shimizu T. Disproportionality analysis of hepatotoxic and gastrointestinal adverse events associated with nintedanib using the Japanese Adverse Drug Event Report (JADER) database. In Vivo, 2025: 39: 396-403.

    2024年研究業績

    原著論文（欧文）

    1. Matsuzaki T, Mizoguchi H, Yamada K. The Use of Text Mining to Obtain a Historical Overview of Research on Therapeutic Drug Monitoring. Biological & Pharmaceutical Bulletin, 2024; 47(11): 1883-1892. Editor's pick.
    2. Katsura H, Suga Y, Kubo A, Sugimura H, Kumatani K, Haruki K, Yonezawa M, Narita A, Ishijima R, Ikesue H, Toi H, Takata N. Risk evaluation of proton pump inhibitors for panitumumab-related hypomagnesemia in patients with metastatic colorectal cancer. Biological & Pharmaceutical Bulletin, 2024; 47: 98-103.
    3. Kato N, Nakai T, Kodama S, Koyama S, Nakane S, Wada Y, Oda H, Katayama H, Mase H, Miyagawa Y, Miyazaki M, Yamada S, Yamada K. Risk factors for thrombocytopenia induced by capecitabine plus oxaliplatin therapy in patients with colorectal cancer. In Vivo, 2024; 38: 1243-1252.
    4. Takagi M, Sagara A, Kumakura Y, Watanabe M, Inoue R, Miyazaki M, Ohka F, Motomura K, Natsume A, Wakabayashi T, Saito R, Yamada K. Risk factors for nausea and vomiting requiring the daily administration of 5-HT3 receptor antagonists in radiotherapy combined with temozolomide for high-grade glioma. Nagoya Journal of Medical Science, 2024; 86: 304-313.
    5. Oku H, Yoshida S, Hotta T, Muroi H, Fukushima K, Irie K, Hirano T, Shimomura Y, Ishikawa T, Ikesue H, Muroi N, Hashida T, Sugioka N. Effect of Hematopoietic Stem Cell Transplantation Regimen on Tacrolimus Pharmacokinetics. Current Therapeutic Research, 2024; 102: 100775.
    6. Geyao Dong, Tsuyoshi Nakai, Tetsuo Matsuzaki : A novel plasmid-based experimental system in Saccharomyces cerevisiae that enables the introduction of 10 different plasmids into cells. FEBS Open Bio, 2024; 14(12): 1955-1971.

    2023年研究業績

    原著論文（欧文）

    1. Tanaka R, Liao J, Hada K, Mori D, Nagai T, Matsuzaki T, Nabeshima T, Kaibuchi K, Ozaki N, Mizoguchi H, Yamada K. Inhibition of Rho-kinase ameliorates decreased spine density in the medial prefrontal cortex and methamphetamine-induced cognitive dysfunction in mice carrying schizophrenia-associated mutations of the Arhgap10 gene. Pharmacological Research. Jan;187:106589. (doi: 10.1016/j.phrs.2022.106589.)
    2. Matsumura Y, Kawarada Y, Matsuo M, Yokota K, Mizoguchi H, Akiyama M, Yamada K. Retrospective Analysis of Neutrophil-to-Lymphocyte Ratio in Patientswith Melanoma Who Received Ipilimumab Monotherapy or Ipilimumab in Combination with Nivolumab in Japan. Biological & Pharmaceutical Bulletin, 2023; 46(3): 427-431. Editor's pick.
    3. Liao J, Dong G, Zhu W, Wulaer B, Mizoguchi H, Sawahata M, Liu Y, Kaibuchi K, Ozaki N, Nabeshima T, Nagai T, Yamada K. Rho kinase inhibitors ameliorate cognitive impairment in a male mouse model of methamphetamine-induced schizophrenia. Pharmacological Research, 2023; 194: 106838.
    4. Hirabatake M, Ikesue H, Yoshino S, Morimoto M, Yamasaki T, Hashida T, Kawakita M, Muroi N. Pharmacist-urologist collaborative management for patients with renal cell carcinoma receiving pazopanib monotherapy. Biological & Pharmaceutical Bulletin, 2023; 46: 1065-1071.
    5. Yamaoka K, Irie K, Hiramoto N, Hirabatake M, Ikesue H, Hashida T, Shimizu T, Ishikawa T, Muroi N. Safety and blood levels of daratumumab after switching from intravenous to subcutaneous administration in patients with multiple myeloma. Investigational New Drugs, 2023; 41: 761-767.

    受賞

    1. 薬剤部長 山田清文「令和5年度愛知県薬事功労者知事表彰」（2023年10月16日）

    2. 薬剤部長 山田清文「令和5年度愛知県病院薬剤師会功労賞」（2023年6月25日）

    3. 薬剤部長 山田清文「日本病院薬剤師会 令和5年度病院薬学賞」（2023年5月27日）

    4. 中村美菜「日本医療薬学会第6回フレッシャーズ・カンファランス優秀演題発表賞（2023年6月11日）」pdf
      　演題：レンボレキサントの安全性に関する年齢層別比較
      　演者：中村美菜（2021年度レジデント修了生）、堀田彰悟、小木曽若菜（2019年度レジデント修了生）、溝口博之、山田清文

    5. 「日本医療薬学会 医療薬学誌論文賞（2023年6月8日）」
      　著者　　：南島拓矢（2018年度レジデント修了生）、肥田裕丈、宮崎雅之、今　俊介（2016年度レジデント修了生）、千﨑康司、永井　拓、山田清文
      　論文題目：免疫チェックポイント阻害薬の有効性および安全性に対する抗菌薬使用の影響

    6. 内田美月「日本医療薬学会 Postdoctoral Award（2023年6月8日）」
      　学位論文題目：精神疾患の情動・認知機能におけるグリア型グルタミン酸トランスポーターの機能的役割に関する研究

    7. 岩田彩生乃「第12回日本薬剤師レジデントフォーラム優秀ポスター賞（2023年3月5日）」pdf
      　演題：双極性障害治療におけるバルプロ酸血中総濃度や副作用に関連した検査値の変化に対する血清ALB値の影響
      　演者：岩田彩生乃（2021、2022年度薬剤師レジデント修了生）、肥田裕丈、細見周平、倉地茜、溝口博之、山田清文

    8. 小西ゆう子「第12回日本薬剤師レジデントフォーラム優秀ポスター賞（2023年3月5日）」pdf
      　演題：ミロガバリン及びプレガバリンの疼痛緩和効果に影響を与える因子の探索
      　演者：小西ゆう子（2021、2022年度薬剤師レジデント修了生）、竹内佐織（2018年度レジデント修了生）、稲垣孝行、井上理香子、宮川泰宏、溝口博之、山田清文

    9. Dong Geyao大学院生　「JSNP Excellent Presentation Award for CINP 2023」
      演題名「Comprehensive Phosphoproteomic Analysis in Reelin Mutant Mice Identified Crucial Role Of Twinfilin1 in Spine Development And Actin Dynamics.」

    2022年研究業績

    原著論文（欧文）

    1. Takase S, Liao J, Liu Y, Tanaka R, Miyagawa Y, Sawahata M, Sobue A, Mizoguchi H, Nagai T, Kaibuchi K, Ozaki N, Yamada K. Antipsychotic-like effects of fasudil, a Rho-kinase inhibitor, in a pharmacologic animal model of schizophrenia. European Journal of Pharmacology. Sep 15;931:175207. (doi: 10.1016/j.ejphar.2022.175207.)
    2. Wu Mengya, Funahashi Yasuhiro, Takano Tetsuya, Hossen Emran, Ahammad Rijwan Uddin, Tsuboi Daisuke, Amano Mutsuki, Yamada Kiyofumi, Kaibuchi Kozo. Rho-Rho-Kinase Regulates Ras-ERK Signaling Through SynGAP1 for Dendritic Spine Morphology. Neurochemical Research. Sep;47(9):2757-2772. (doi: 10.1007/s11064-022-03623-y.)
    3. Matsuzaki T, Kato Y, Mizoguchi H, Yamada K. A machine learning model that emulates experts' decision making in vancomycin initial dose planning. Journal of Pharmacological Sciences, 2022; 148(4): 358-363.
    4. Ito A, Ichikawa K, Miyazaki M, Sagara A, Motegi T, Ando Y, Senzaki K, Nagai T, Yamada K. Clinical impact of standardized creatinine on dose adjustment of capecitabine. Nagoya Journal of Medical Science, 2022; 84: 547-553.
    5. Hirabatake M, Ikesue H, Iwama Y, Irie K, Yoshino S, Yamasaki T, Hashida T, Kawakita M, Muroi N. . Pharmacist-urologist collaborative management improves clinical outcomes in patients with castration-resistant prostate cancer receiving enzalutamide. Frontiers in Pharmacology, 2022; 13:901099.
    6. Faruk,Mo,Tsuboi D,Yamahashi Y,Funahashi Y,Lin YH,TzingounisAV,Yamada K,NagaiT,kaibuchi K. Muscarinic signaling regulates voltage-gated potassium channel KCNQ2 phosphorylation in the nucleus accumbens via protein kinase C for aversive learning. Journal of Neurochemistry. Feb;160(3):325-341. (doi: 10.1111/jnc.15555. )
    7. Liao,JZ,Dong,GY，Wulaer B,Sawahata M,Mizoguchi H,Mori D,Ozaki N,Nabeshima T,Nagai T,Yamada K. Mice with exonic RELN deletion identified from a patient with schizophrenia have impaired visual discrimination learning and reversal learning in touchscreen operant tasks. Behavioural Brain Research. Jan 7;416:113569. 2022. (doi: 10.1016/j.bbr.2021.113569. )

    総説論文（欧文）

    1. Tsuneura Y,Nakai T,Mizoguchi H,Yamada K. New Strategies for Treatment of Neuropsychiatric Disorders Based on Reelin Dysfunction. International Journal of Molecular Sciences. Feb 6;23(3):1829. (doi: 10.3390/ijms23031829.)

    受賞

    1. 南川友香「第28回日本腹膜透析医学会コメディカル賞（2022年11月25日）」pdf
      　演題：腹膜透析患者の腹膜炎発症関連因子の検討
      　演者：南川友香（2019年度レジデント修了生）、肥田裕丈、福澤翔太、鈴木康弘、水野正司、山田清文

    2. 薬剤部長 山田清文「日本医療薬学会賞（2022年9月25日）」
      　受賞テーマ：遺伝および環境要因を踏まえた神経精神疾患モデルの創出と医療薬学研究への応用
    3. 　　　
    4. Zhu Youyun大学院生「第142回日本薬理学会近畿部会優秀発表賞」
      　演題名「Neuronal morphological impairments in the model mice carrying the same deletion of RELN gene that was identified in a 　　　　　Japanese schizophrenia patient.」

    2021年研究業績

    原著論文（欧文）

    1. Ahammad RU,Nishioka T,Yoshimoto J,Kannon T,Amano M,Funahashi Y,Tsuboi D,Faruk Mo,Yamahashi Y,Yamada K,Nagai T, Kaibuchi K. KANPHOS: A Database of Kinase-Associated Neural Protein hosphorylation in the Brain. Cells. Dec 24;11(1):47.2021. (doi: 10.3390/cells11010047.)
    2. Uchida M,Noda Y,Hasegawa S,Hida H,Taniguchi M,Mouri A,Yoshimi A,Nabeshima T,Yamada K,Aida T,Tanaka K,Ozaki N. Early postnatal inhibition of GLAST causes abnormalities of psychobehaviors and neuronal morphology in adult mice. Neurochemistry International. Nov;150:105177. (doi: 10.1016/j.neuint.2021.105177.)
    3. Yoshimi A,Shiroma Y,Iwata M,Nakamura M,Torii-Goto A,Hida H,Tanaka N,Miyazaki M,Yamada K,Noda Y. Survey of chemotherapy-induced nausea and vomiting in patients eith urothelial carcinoma. Molecular and Clinical Oncology. Oct;15(4):219. (doi: 10.3892/mco.2021.2384.)
    4. Sawahata M,AsanoH,Nagai T,Ito N,Kohno T,Nabeshima T,Hattori M,Yamada K. Microinjection of Reelin into the mPFC prevents MK-801-induced recognition memory impairment in mice. Pharmacological Research. Nov;173:105832. 2021. (doi: 10.1016/j.phrs.2021.105832.)
    5. Mizoguchi A,Banno R,Sun R,Yaginuma H,Taki K,Kobayashi T,Sugiyama M,Tsunekawa T,Onoue T,Takagi H,Hagiwara D,Ito Y,Iwama S,Suga H,Nagai T,Yamada K,Arima H. Glucocorticoid receptor signaling in ventral tegmental area neurons increases the rewarding value of a high-fat diet in mice. Scientific Reports. Jun 18;11(1):12873. (Jun 18;11(1):12873.)
    6. Tsuneura Y, Sawahata M, Itoh N, Miyajima R, Mori D, Kohno T, Hattori M, Sobue A, Nagai T, Mizoguchi H, Nabeshima T, Ozaki N, Yamada K. Analysis of Reelin signaling and neurodevelopmental trajectory in primary cultured cortical neurons with RELN deletion identified in schizophrenia. Neurochemistry International. Mar;144:104954. (doi: 10.1016/j.neuint.2020.104954.)
    7. Lin You-Hsin, Yamahashi Yukie, Kuroda Keisuke, Faruk Omar, Zhang Xinjian, Yamada Kiyofumi, Yamanaka Akihiro, Nagai Taku, Kaibuchi Kozo. Accumbal D2R-medium spiny neurons regulate aversive behaviors through PKA-Rap1 pathway. Neurochemistry International. Feb;143:104935. (doi: 10.1016/j.neuint.2020.104935.)
    8. Hada Kazuhiro, Wulaer Bolati, Nagai Taku, Itoh Norimichi, Sawahata Masahito, Sobue Akira, Mizoguchi Hiroyuki, Mori Daisuke, Kushima Itaru, Nabeshima Toshitaka, Ozaki Norio, Yamada Kiyofumi.Mice carrying a schizophrenia-associated mutation of the Arhgap10 gene are vulnerable to the effects of methamphetamine treatment on cognitive function: association with morphological abnormalities in striatal neurons. Molecular Brain. Jan 22;14(1):21. (doi: 10.1186/s13041-021-00735-4.)

    総説論文（欧文）

    1. Nakai T, Yamada K, Mizoguchi H. Alzheimer's Disease Animal Models: Elucidation of Biomarkers and Therapeutic Approaches for Cognitive Impairment. International Journal of Molecular Sciences. May 24;22(11):5549. 2021. (doi: 10.3390/ijms22115549.)

    受賞

    1. 夏目彩佳「日本病院薬剤師会東海ブロック・日本薬学会東海支部合同学術大会2021ベストプレゼン賞（2021年10月30日～11月7日）」pdf
      　演題：精神科におけるルビプロストン、エロビキシバット、リナクロチドの使用実態調査
      　演者：夏目彩佳 （2020年度レジデント修了生）、肥田裕丈、堀田彰悟、石井沙也加、溝口博之、山田清文
    2. 松村由佳「日本病院薬剤師会東海ブロック・日本薬学会東海支部合同学術大会2021ベストプレゼン賞（2021年10月30日～11月7日）」pdf
      　演題：好中球リンパ球比（ NLR ）が日本人悪性黒色腫患者のイピリムマブ投与回数に及ぼす影響
      　演者：松村由佳 (2020年度レジデント修了生）、川原田祐貴、松尾モモ (2017年度レジデント修了生）、溝口博之、山田清文
    3. Dong Geyao大学院生「第141回日本薬理学会近畿部会最優秀発表賞」
      　演題名「Phosphorylation of twinfilin-1 involved in the reelin signaling plays a crucial role in spine development.」
    4. 田中 里奈子大学院生 「JSNP Excellent Presentation Awerd for AsCNP 2021及び鍋島賞受賞」
      　演題名「Effect of a Rho-kinase inhibitor, fasudil, on spine density in the mPFC of mice carrying a mutation of the Arhgap10 gene.」
    5. 田中 里奈子大学院生 「The 23rd Korea-Japan Joint Seminar on Pharmacology　ePoster Best Presentation Award」
      　演題名「Effect of fasudil in a pharmacologic animal model of schizophrenia.」
    6. 田中 里奈子大学院生 「東海国立大学機構融合フロンティア次世代リサーチャー事業の東海国立大学機構融合フロンティア次世代リサーチャー（バイオサイエンス分野）」認定 (2021年10月1日～2023年3月)

    2020年研究業績

    原著論文（欧文）

    1. Wulaer Bolati, Hada Kazuhiro, Sobue Akira, Itoh Norimichi, Nabeshima Toshitaka, Nagai Taku, Yamada Kiyofumi.Overexpression of astroglial major histocompatibility complex class I in the medial prefrontal cortex impairs visual discrimination learning in mice. Molecular Brain. Dec 14;13(1):170. 2020. (doi: 10.1186/s13041-020-00710-5.)
    2. Hase Tetsunari, Miyazaki Masayuki, Ichikawa Kazuya, Yogo Naoyuki, Ozawa Naoya, Hatta Takahiro, Ando Masahiko, Sato Mitsuo, Kondo Masashi, Yamada Kiyofumi, Hasegawa Yoshinori. Short hydration with 20 mEq of magnesium supplementation for lung cancer patients receiving cisplatin-based chemotherapy: a prospective study. International Journal of Clinical Oncology. Nov;25(11):1928-1935. (doi: 10.1007/s10147-020-01755-1.)
    3. Ibi Daisuke, Nakasai Genki, Koide Nayu, Sawahata Masahito, Kohno Takao, Takaba Rika, Nagai Taku, Hattori Mitsuharu, Nabeshima Toshitaka, Yamada Kiyofumi, Hiramatsu Masayuki. Reelin Supplementation Into the Hippocampus Rescues Abnormal Behavior in a Mouse Model of Neurodevelopmental Disorders.Frontiers in Cellular Neuroscience, Sep 2;14:285.2020. (doi: 10.3389/fncel.2020.00285.)
    4. Ozawa Naoya, Hase Tetsunari, Hatta Takahiro, Sagara Atsunobu, Ichikawa Kazuya, Miyazaki Masayuki, Yogo Naoyuki, Ando Masahiko, Hashimoto Naozumi, Yamada Kiyofumi, Hasegawa Yoshinori. Comparing incidences of infusion site reactions between brand-name and generic vinorelbine in patients with non-small cell lung cancer. British Journal of Clinical Pharmacology, Mar;87(3):1318-1326. (doi: 10.1111/bcp.14516.)
    5. Sato Yoshitaka, Iguchi Mitsutaka, Kato Yoshiaki, Morioka Hiroshi, Hirabayashi Aki, Tetsuka Nobuyuki, Tomita Yuka, Kato Daizo, Yamada Kiyofumi, Kimura Hiroshi, Yagi Tetsuya. Number of concomitant drugs with thrombocytopenic adverse effects and the extent inflammatory response resolution are risk factors for thrombocytopenia in patients treated with linezolid for more than 14 days. Nagoya Journal of Medical Science, 82(3): 407-414.2020. (10.18999/nagjms.82.3.407.)
    6. Sekiguchi Mariko, Sobue Akira, Kushima Itaru, Wang Chenyao, Arioka Yuko, Kato Hidekazu, Kodama Akiko, Kubo Hisako, Ito Norimichi, Sawahata Masahito, Hada Kazuhiro, Ikeda Ryosuke, Shinno Mio, Mizukoshi Chikara, Tsujimura Keita, Yoshimi Akira, Ishizuka Kanako, Takasaki Yuto, Kimura Hiroki, Xing Jingrui, Yu Yanjie, Yamamoto Maeri, Okada Takashi, Shishido Emiko, Inada Toshiya, Nakatochi Masahiro, Takano Tetsuya, Kuroda Keisuke, Amano Mutsuki, Aleksic Branko, Yamomoto Takashi, Sakuma Tetsushi, Aida Tomomi, Tanaka Kohichi, Hashimoto Ryota, Arai Makoto, Ikeda Masashi, Iwata Nakao, Shimamura Teppei, Nagai Taku, Nabeshima Toshitaka, Kaibuchi Kozo, Yamada Kiyofumi, Mori Daisuke, Ozaki Norio. ARHGAP10, which encodes Rho GTPase-activating protein 10, is a novel gene for schizophrenia risk. Translational Psychiatry, Jul 22;10(1):247.(doi: 10.1038/s41398-020-00917-z.)
    7. Hori Kei, Yamashiro Kunihiko, Nagai Taku, Shan Wei, Egusa Saki F., Shimaoka Kazumi, Kuniishi Hiroshi, Sekiguchi Masayuki, Go Yasuhiro, Tatsumoto Shoji, Yamada Mitsuyo, Shiraishi Reika, Kanno Kouta, Miyashita Satoshi, Sakamoto Asami, Abe Manabu, Sakimura Kenji, Sone Masaki, Sohya Kazuhiro, Kunugi Hiroshi, Wada Keiji, Yamada Mitsuhiko, Yamada Kiyofumi, Hoshino Mikio. AUTS2 Regulation of Synapses for Proper Synaptic Inputs and Social Communication. iScience, Jun 26;23(6). 2020. (doi: 10.1016/j.isci.2020.101183.)
    8. Wulaer Bolati, Kunisawa Kazuo, Hada Kazuhiro, Suento Willy Jaya, Kubota Hisayoshi, Iida Tsubasa, Kosuge Aika, Nagai Taku, Yamada Kiyofumi, Nitta Atsumi, Yamamoto Yasuko, Saito Kuniaki, Mouri Akihiro, Nabeshima Toshitaka:  Shati/Nat8l deficiency disrupts adult neurogenesis and causes attentional impairment through dopaminergic neuronal dysfunction in the dentate gyrus. Journal of Neurochemistry, May;157(3):642-655. 2021. (doi: 10.1111/jnc.15022.)
    9. Sawahata Masahito, Mori Daisuke, Arioka Yuko, Kubo Hisako, Kushima Itaru, Kitagawa Kanako, Sobue Akira, Shishido Emiko, Sekiguchi Mariko, Kodama Akiko, Ikeda Ryosuke, Aleksic Branko, Kimura Hiroki, Ishizuka Kanako, Nagai Taku, Kaibuchi Kozo, Nabeshima Toshitaka, Yamada Kiyofumi, Ozaki Norio: Generation and analysis of novel Reln-deleted mouse model corresponding to exonic Reln deletion in schizophrenia. Psychiatry and Clinical Neurosciences, May;74(5):318-327. 2020. (doi: 10.1111/pcn.12993.)
    10. Saito R, Koebis M, Nagai T, Shimizu K, Liao J, Wulaer B, Sugaya Y, Nagahama K, Uesaka N, Kushima I, Mori D, Maruyama K, Nakao K, Kurihara H, Yamada K, Kano M, Fukada Y, Ozaki N, Aiba A: Comprehensive analysis of a novel mouse model of the 22q11.2 deletion syndrome: A model with the most common 3.0-Mb deletion at the human 22q11.2 locus. Translational Psychiatry, Feb 5; 10(1): 35., 2020. (doi: 10.1038/s41398-020-0723-z.)

    2019年研究業績

    原著論文（欧文）

    1. Funahashi Y, Ariza A, Emi R, Xu Y, Shan W, Suzuki K, Kozawa S, Ahammad R, Wu M, Takano T, Yura Y, Kuroda K, Nagai T, Amano M, Yamada K, Kaibuchi K.: Phosphorylation of NPAS4 by MAPK regulates reward-related gene expression and behaviors. Cell Reports, 29(10), 3235, 2019.(doi: 10.1016/j.celrep.2019.10.116)
    2. Hasegawa S, Yoshimi A, Mouri A, Uchida Y, Hida H, Mishina M, Yamada K, Ozaki N, Nabeshima T, Noda Y.: Acute administration of ketamine attenuates the impairment of social behaviors induced by social defeat stress exposure as juveniles via activation of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors. Neuropharmacology, 148,107-116, 2019.(doi: 10.1016/j.neuropharm. 2018.12.020.)
    3. Kitagawa K, Nagai T, Yamada K.: Pharmacological and proteomic analyses of neonatal polyl: C-treated adult mice. Neuroscience Research, 147: 39-47, 2019.(doi: 10.1016/j.neures.)
    4. Nakamura Y, Nakatochi M, Kunimoto S, Okada T, Aleksic B, Toyama M, Shiino T, Morikawa M, Yamauchi A, Yoshimi A, Furukawa-Hibi Y, Nagai T, Ohara M, Kubota C, Yamada K, Ozaki N. Methylation analysis for postpartum depression: a case control study. BMC Psychiatry, 19(1): 190, 2019.(doi: 10.1186/s12888-019-2172-x.)
    5. Uchida M, Hida H, Mori K, Yoshimi A, Kitagaki S, Yamada K, Hiraoka Y, Aida T, Tanaka K, Ozaki N, Noda Y: Functional roles of the glial glutamate transporter (GLAST) in emotional and cognitive abnormalities of mice after repeated phencyclidine administration. European Neuropsychopharmacology, 29: 914-924, 2019.
    6. Shan W, Nagai T, Tanaka M, Itoh N, Furukawa-Hibi Y, Nabeshima T, Sokabe M, Yamada K: Neuronal PAS domain protein 4 (Npas4) controls neuronal homeostasis in pentylenetetrazole-induced epilepsy through the induction of Homer1a. Journal of Neurochemistry, 145(1):19-33, 2018.(doi: 10.1111/jnc.14274)
    7. Yoshimi A, Yamada S, Kunimoto S, Aleksic B, Hirakawa A, Ohashi M, Matsumoto Y, Hada K, Itoh N, Arioka Y, Kimura H, Kushima I, Nakamura Y, Shiino T, Mori D, Tanaka S, Hamada S, Noda Y, Nagai T, Yamada K, Ozaki N: Proteomic analysis of lymphoblastoid cell lines from schizophrenic patients. Translational Psychiatry, 9(1): 126, 2019.(doi: 10.1038/s41398-019-0479-5)
    8. Zhang X, Nagai T, Ahammad RU, Kuroda K, Nakamuta S, Nakano T, Yukinawa N, Funahashi Y, Yamahashi Y, Amano M, Yoshimoto J, Yamada K, Kaibuchi K: Balance between dopamine and adenosine signals regulates the PKA/Rap1 pathway in striatal medium spiny neurons. Neurochemistry International, 122: 8-18, 2019.(doi: 10.1016/j.neuint. 2018.10.008.)

    総説論文（欧文）

    1. Mizoguchi H, Yamada K: Methamphetamine use causes cognitive impairment and altered decision-making. Neurochem Int. 124: 106-113,2019.(doi: 10.1016/j.neuint.2018.12.019.., 2019.)

    2018年研究業績

    原著論文（欧文）

    1. Hasegawa S, Miyake Y, Yoshimi A, Mouri A, Hida H, Yamada K, Ozaki N, Nabeshima T, Noda Y.: Dysfunction of Serotonergic and Dopaminergic Neuronal Systems in the Antidepressant-Resistant Impairment of Social Behaviors Induced by Social Defeat Stress Exposure as Juveniles. International Journal of Neuropsychopharmacology, 21(9): 837-846, 2018.( doi: 10.1093/ijnp/pyy038.)
    2. Mouri A, Ukai M, Uchida M, Hasegawa S, Taniguchi M, Ito T, Hida H, Yoshimi A, Yamada K, Kunimoto S, Ozaki N, Nabeshima T and Noda Y.: Juvenile social defeat stress exposure persistently impairs social behaviors and neurogenesis. Neuropharmacology, 133: 23-37, 2018.
    3. Mizoguchi H, Wang T, Kusaba M, Fukumoto K, Yamada K. Nicotine and varenicline ameliorate changes in reward-based choice strategy and altered decision-making in methamphetamine-treated rats. Behavioural Brain Research, Feb 1;359:935-941, 2019. (doi: 10.1016/j.bbr.2018.06.016.)
    4. Nguyen PT, Shin EJ, Dang DK, Tran HQ, Jang CG, Jeong JH, Lee YJ, Lee YS, Yamada K, Nabeshima T, Kim HC: Role of dopamine D1 receptor in 3-fluoromethamphetamine-induced neurotoxicity in mice. Neurochemistry International, 113: 69-84, 2018.
    5. Tajima H, Izumi T, Miyachi S, Matsubara N, Ito M, Imai T, Nishihori M, Shintai K, Okamoto S, Arak Y, Kumakura Y, Furukawa-Hibi Y, Yamada K and Wakabayashi T: Association between CYP2C19 genotype and the additional effect of cilostazol to clopidogrel resistance in neuroendovascular therapy. Nagoya Journal of Medical Science, 80: 207-215, 2018.
    6. Tran V, Shin E-J, Nguyen LTT, Lee Y, Kim DJ, Jeong JH, Jang CG, Nah SY, Toriumi K, Nabeshima T, Yamada K, Kim HC: Protein Kinase Cδ Gene Depletion Protects Against Methamphetamine-Induced Impairments in Recognition Memory and ERK1/2 Signaling via Upregulation of Glutathione Peroxidase-1 Gene. Molecular Neurobiology, 55: 4136-4159, 2018.(doi: 10.1007/s12035-017-0638-8.)
    7. Saifullah MAB, Nagai T, Kuroda K, Wulaer B, Nabeshima T, Kaibuchi K, Yamada K.: Cell type-specific activation of mitogen-activated protein kinase in D1 receptor-expressing neurons of the nucleus accumbens potentiates stimulus-reward learning in mice. Scientific Reports, 8: 14413, 2018.(doi: 10.1038/s41598-018-32840-1.)
    8. Sobue A, Itoh N, Nagai T, Shan W, Hada K, Nakajima A, Murakami Y, Mouri A, Yamamoto Y, Nabeshima T, Saito K, Yamada K: Astroglial major histocompatibility complex class I following immune activation leads to behavioral and neuropathological changes. Glia, 66(5): 1034-1052, 2018.(doi: 10.1002/glia.23299)
    9. Sobue A, Kushima I, Nagai T, Shan W, Kohno T, Aleksic B, Aoyama Y, Mori D, Arioka Y, Kawano N, Yamamoto M, Hattori M, Nabeshima T, Yamada K, Ozaki N.: Genetic and animal model analyses reveal the pathogenic role of a novel deletion of RELN in schizophrenia. Scientific Reports, 8: 13046, 2018.(doi: 10.1038/s41598-018-31390-w)
    10. Wulaer B, Nagai T, Sobue A, Itoh N, Kuroda K, Kaibuchi K, Nabeshima T, Yamada K: Repetitive and compulsive-like behaviors lead to cognitive dysfunction in Disc1Δ2-3/Δ2-3 mice. Genes, Brain and Behavior, 17(8), UNSP e12478,2018.(doi: 10.1111/gbb.12478.)
    11. Yamada S, Itoh N, Nagai N, Nakai T, Ibi D, Nakajima A, Nabeshima T, Yamada K.: Innate immune activation of astrocytes impairs neurodevelopment via upregulation of follistatin-like 1 and interferon-induced transmembrane protein 3. Journal of Neuroimmunology, 15(1): 295, 2018.(doi: 10.1186/s12974-018-1332-0.)

    受賞

    1. 羽田 和弘大学院生「第133回日本薬理学会近畿部会優秀発表賞」
      演題名「新規統合失調症関連遺伝子ARHGAP10変異マウスの行動薬理学的・神経科学的解析」

    2017年研究業績

    原著論文（欧文）

    1. Itoh N, Nagai T, Watanabe T, Taki K, Nabeshima T, Kaibuchi K, Yamada K.: Valocin-containing protein (VCP) is a novel IQ motif-containing GTPase activating protein 1 (IQGAP1) interacting protein. Biochemical and Biophysical Research Communications, 493:1384-1389, 2017.
    2. Tran HQ, Chung YH, Shin EJ, Tran T-Y, Jeong JH, Jang CG, Nah SY, Yamada K, Nabeshima T, Kim HC: Mk-801, but not naloxone, atteneuates high-dose dextropethorpahn-induced convulsive behavior: Possble involvement of the GluN2B receptor. Toxicology and Applied Pharmacology, 334:158-166, 2017.
    3. Tran V, Shin E-J, Nguyen LTT, Lee Y, Kim DJ, Jeong JH, Jang CG, Nah SY, Toriumi K, Nabeshima T, Yamada K, Kim HC: Protein Kinase Cδ Gene Depletion Protects Against Methamphetamine-Induced Impairments in Recognition Memory and ERK1/2 Signaling via Upregulation of Glutathione Peroxidase-1 Gene. Molecular Neurobiology, doi:10.1007/s12035-017-0638-8, 2017.
    4. Mouri A, Noda Y, Niwa M, Matsumoto Y, Mamiya T, Nitta A, Yamada K, Furukawa S, Iwamura T, Nabeshima T: The involvement of brain-derived neurotrophic factor in 3,4-methylenedioxymethamphetamine-induced place preference and behavioral sensitization. Behavioural Brain Research, 329:157-165, 2017.
    5. Konishi H, Ohgami N, Matsushita A, Kondo Y, Aoyama Y, Kobayashi M, Nagai T, Ugawa S, Yamada K, Kato M, Kiyama H: Exposure to diphtheria toxin during the juvenile period impairs both inner and outer hair cells in C57BL/6 mice. Neuroscience, 351:15-23, 2017.
    6. Kubo K, Deguchi K, Nagai T, Ito Y, Endo T, Benner S, Shan W, Kitazawa A, Aramaki M, Ishii K, Kakeyama M, Tohyama C, Tanaka K, Takashima S, Nakayama M, Itoh M, Antalffy M, Armstrong D D, Yamada K, Inoue K, Nakajima K: Association of impaired neuronal migration with cognitive deficits in extremely preterm infants. JCI Insight, 2017 May 18;2(10). pii: 88609. doi: 10.1172/jci.insight.88609.

    総説論文（欧文）

    1. Caraci F, Enna SJ, Zohar J, Racagni G, Zalsman G, van den Brink W, Kasper S, Koob GF, Pariante CM, Piazza PV, Yamada K, Spedding M, Drago F: A new nomenclature for classifying psychotropic drugs. British Journal of Clinical Pharmacology, 2017, 83:1614-1616.

    2. Shin EJ, Dang DK, The-Vinh Tran TV, Tan HQ, Ji Hoon Jeong JH, Nah SY, Jang CG, Yamada K, Nabeshima T, Kim HC: Current understanding of methamphetamine-associated dopaminergic neurodegeneration and psychotoxic behaviors. Archives of Pharmacal Research, 2017, 40: 403-428. DOI 10.1007/s12272-017-0897-y.

    2016年研究業績

    原著論文（欧文）

    1. Tran V, Shin E-J, Jeong JH, Lee JW, Lee Y, Jang CG, Nah SY, Lei XG, Toriumi K, Yamada K, Nabeshima T, Kim HC. Protective potential of the glutathione peroxidase-1 gene in abnormal behaviors induced by phencyclidine in mice. Molecular Neurobiology, DOI 10.1007/s12035-016-0239-y, 2016.
    2. Tran V, Shin EJ, Ko SK, Nam Y, Chung YH, Jeong JH, Jang CG, Nah SY, Yamada K, Nabeshima T, Byun JK, Kim HC: Mountain-cultivated ginseng attenuates phencyclidine-induced abnormal behaviors in mice by positive modulation of glutathione in the prefrontal cortex of mice. Journal of Medicinal Food, 19:1-9, 2016.
    3. Tran V, Chung YH, Shin E-J, Kim WK, Lee JC, Jeong JH, Wie MB, Jang CG, Yamada K, Nabeshima T, Kim HC. High-dose dextromethorphan produces myelinod bodies in the hippocampus of rats. Journal of Pharmacological Sciences, 132:166-170, 2016.
    4. Nagai T, Nakamuta S, Kuroda K, Nakauchi S, Nishioka T, Takano T, Zhang X, Tsuboi D, Funahashi Y, Nakano T, Yoshimoto J, Kobayashi K, Uchigashima M, Watanabe M, Miura M, Nishi A, Kobayashi K, Yamada K, Amano M, Kaibuchi K.: Phospho-proteomics of the dopamine pathway enables discovery of Rap1 activation as a reward signal in vivo. Neuron 89: 550-565, 2016.
    5. Aoyama Y, Toriumi K, Mouri A, Hattori T, Ueda E, Shimato A, Sakakibara N, Soh Y, Mamiya T, Nagai T, Kim HC, Hiramatsu M, Nabeshima T, Yamada K: Prenatal nicotine exposure impairs the proliferation of neuronal progenitors, leading to fewer glutamatergic neurons in the medial prefrontal cortex. Neuropsychopharmacology 41: 578-589, 2016.

    総説論文（欧文）

    1. Itoh N, Enomoto A, Nagai T, Takahashi M, Yamada K: Molecular mechanism linking BDNF/TrkB signaling with the NMDA receptor in memory: The role of Girdin in the CNS. Reviews in the Neurosciences, 2016, 27:481-90.

    2015年研究業績

    原著論文（欧文）

    1. Sakaguchi H, MuramatsuH, Makishima H, Xu Y, Hibi Y, Wang X, Narita A, Okuno Y, Yoshida K, Shiraishi Y, Doisaki S, Yoshida N, Hama A, Takahashi Y, Yamada K, Miyano S, Ogawa S, Maciejewski JP, Kojima S.: Aberrant DNA methylation is associated with a poor outcome in juvenile myelomonocytic leukemia. PLOS ONE, 2015 Dec 31;10(12):e0145394. doi: 10.1371/journal.pone.0145394.
    2. Hori K, Nagai T, Shan W, Sakamoto A, Abe M, Yamazaki M, Sakimura K, Yamada K, Hoshino M: Heterozygous disruption of Autism susceptibility candidate 2 causes impaired emotional control and cognitive memory. PLOS ONE, 10(12): e0145979.doi:10.1371/journal.pone.014579, 2015
    3. Mita T, Furukawa-Hibi Y, Takeuchi H, Hattori H, Yamada K, Hibi H, Ueda M, Yamamoto A: Conditioned medium from the stem cells of human dental pulp improves cognitive function in a mouse model of Alzheimer's disease. Behavioural Brain Research, 293:189-197, 2015.
    4. Furukawa-Hibi Y, Yun J, Nagai T, Yamada K: Stress increases DNA methylation of the neuronal PAS domain 4 (Npas4) gene. Neuroreport 26:827-832, 2015.
    5. Mizoguchi H, Katahira K, Inutsuka A, Fukumoto K, Wang T, Nagai T, Sato J, Sawada M, Ohira H, Yamanaka A, Yamada K: Insular neural system controls decision-making in healthy and methamphetamine-treated rats. Proceedings of the National Academy of Sciences, 112:E3930-3939, 2015.
    6. Udagawa T, Fujioka Y, Tanaka M, Honda D, Yokoi S, Riku Y, Ibi D, Nagai T, Yamada K, Watanabe H, Katsuno M, Inada T, Ohno K, Sokabe M, Okado H, Ishigaki S, Sobue G: FUS regulates AMPA receptor function and FTLD/ALS-associated behavior via GluA1 mRNA stabilization. Nature Communications, 6:7098 doi: 10.1038/ncomms8098, 2015.
    7. Ishii K, Nagai T, Hirota Y, Noda M, Nabeshima T, Yamada K, Kubo K, Nakajima K.: Reelin has a preventive effect on phencyclidine-induced cognitive and sensory-motor gating deficits. Neuroscience Research, 96:30-36, 2015.
    8. Nakajima A, Aoyama Y, Shin, EJ, Nam Y, Kim HC, Nagai T, Yokosuka A, Mimaki Y, Yokoi, T, Ohizumi Y, Yamada K: Nobiletin, a citrus flavonoid, improves cognitive impairment and reduces soluble Ab levels in a triple transgenic mouse model of Alzheimer's disease (3XTg-AD). Behavioural Brain Research, 289: 69-77, 2015.
    9. Hida H, Mouri A, Mori K, Matsumoto Y, Seki T, Taniguchi M, Yamada K, Iwamoto K, Ozaki N, Nabeshima T, Noda Y: The complex mechanism of blonanserin action involving D3-5-HT2A and D1-NMDA receptors in the mPFC. Neuropsychopharmacology 40:601-613, 2015.

    受賞

    1. 宮崎　雅之「日本病院薬剤師会東海ブロック日本薬学会東海支部合同学術大会2015　ベストプレゼンテーション賞」
      演題名「小児患者の移植前処置におけるブスルファン血中濃度による投与量設定の取り組み.」

    2014年研究業績

    原著論文（欧文）

    1. Toriumi K, Kondo M, Nagai T, Hashimoto R, Ohi K, Song Z, Tanaka J, Mouri A, Koseki T, Yamamori H, Furukawa-Hibi Y, Mamiya T, Fukushima T, Takeda M, Nitta A, Yamada K, and Nabeshima T.: Deletion of SHATI/NAT8L increases dopamine D1 receptor on the cell surface in the nucleus accumbens, accelerating methamphetamine dependence. International Journal of Neuropsychopharmacology, 17:443-453, 2014.
    2. Hida H, Mouri A, Ando Y, Mori K, Mamiya T, Iwamoto K, Ozaki N,Yamada K, Nabeshima T and Noda Y: Combination of neonatal Polyl:C and adolescent phencyclidine treatments is required to induce behavioral abnormalities with overexpression of GLAST in adult mice. Behavioural Brain Research, 2014, 258:34-42.
    3. Aoyama Y, Mouri A, Toriumi K, Koseki T, Narusawa S, Ikawa N, Mamiya T, Nagai T, Yamada K and Nabeshima T: Clozapine ameliorates epigenetic and behavioral abnormalities induced by phencyclidine through activation of dopamine D1 receptor. International Journal of Neuropsychopharmacology, 2014 , 17(5):723-737.
    4. Mano Y, Kotani T, Ito M, Nagai T, Ichinohashi Y, Yamada K, Ohno K, Kikkawa F and Toyokuni S: Maternal molecular hydrogen administration ameliorates rat fetal hippocampal damage by in utero ischemia-reperfusion. Free Radical Biology and Medicine, 2014, 69:324-330.
    5. Yamada S, Nagai T, Nakai T, Ibi D, Nakajima A, and Yamada K: Matrix metalloproteinase-3 is a possible mediator of neurodevelopmental impairment due to polyI:C-induced innate immune activation of astrocytes. Brain, Behavior, and Immunity, 2014, 38:272-82.
    6. Nakajima N, Ohizumi Y, Yamada K: Anti-dementia activity of nobiletin, a citrus flavonoid. Clinical Psychopharmacology and Neuroscience, 2014, 12(2):75-82.
    7. Hori K, Nagai T, Shan W, Sakamoto A, Taya S, Hashimoto R, Hayashi T, Abe M, Yamazaki M, Nakao K, Nishioka T, Sakimura K, Yamada K, Kaibuchi K, Hoshino M.: Cytoskeletal Regulation by AUTS2 in Neuronal Migration and Neuritogenesis. Cell Reports. 2014, 9:2166-2179.
    8. Nakajima A, Ibi D, Nagai T, Yamada S, Nabeshima T, Yamada K: Induction of interferone-induced transmembrane protein 3 gene expression by lipopolysaccharide in astrocytes. European Journal of Pharmacology, 2014, 745:166-175.
    9. Nakai T, Nagai T, Tanaka M, Itoh N, Asai N, Enomoto A, Asai M, Yamada S, Saifullah MAB, Sokabe M, Takahashi M, Yamada K: Girdin phosphorylation is crucial for synaptic plasticity and memory: a potential role in the interaction of BDNF/TrkB/Akt signaling with NMDA receptor. Journal of Neuroscience, 2014, 34:14995-15008, 2014.
    10. Maeda O, Ando T, Ohmiya N, Ishiguro K, Watanabe O, Miyahara R, Hibi Y, Nagai T, Yamada Yoshihara S, Takahashi H, Nishimura N, Kinoshita M, Asahina R, Kitsuki M, Tatsumi K, Hibi Y, Hirai H, Nagai T, Yamada K, Tsuboi A: Npas4 regulates the expression of Mdm2 that ubiquitinates Dcx to remodel dendritic spines in olfactory bulb interneurons after sensory experience. Cell Reports, 2014, 8:1-15.
    11. Nakai T, Nagai T, Wang R, Yamada S, Kuroda K, Kaibuchi K, Yamada K: Alterations of GABAergic and dopaminergic system in mutant mice with disruption of exons 2 and 3 of the Disc1 gene. Neurochemistry International, 2014, 74:74-83.
    12. Yamada S, Nagai T, Nakai T, Ibi D, Nakajima A, and Yamada K: Matrix metalloproteinase-3 is a possible mediator of neurodevelopmental impairment due to polyI:C-induced innate immune activation of astrocytes. Brain, Behavior, and Immunity, 2014, 38:272-282.
    13. Aoyama Y, Mouri A, Toriumi K, Koseki T, Narusawa S, Ikawa N, Mamiya T, Nagai T, Yamada K, Nabeshima T: Clozapine ameliorates epigenetic and behavioral abnormalities induced by phencyclidine through activation of dopamine D1 receptor. International Journal of Neuropsychopharmacology, 2014, 17:723-737.
    14. Hida H, Mouri A, Ando Y, Mori K, Mamiya T, Iwamoto K, Ozaki N, Yamada K, Nabeshima T, Noda Y: Combination of neonatal Polyl:C and adolescent phencyclidine treatments is required to induce behavioral abnormalities with overexpression of GLAST in adult mice. Behavioural Brain Research, 2014, 258:34-42.
    15. Toriumi K, Kondo M, Nagai T, Hashimoto R, Ohi K, Song Z, Tanaka J, Mouri A, Koseki T, Yamamori H, Furukawa-Hibi Y, Mamiya T, Fukushima T, Takeda M, Nitta A, Yamada K, Nabeshima T.: Deletion of SHATI/NAT8L increases dopamine D1 receptor on the cell surface in the nucleus accumbens, accelerating methamphetamine dependence. International Journal of Neuropsychopharmacology, 2014, 17:443-453.

    2013年研究業績

    原著論文（欧文）

    1. Mouri A, Nagai T, Ibi D and Yamada K: Animal models of schizophrenia for molecular and pharmacological intervention and potential candidate molecules. Neurobiology of Disease, 2013, 53:61-74.
    2. Mizoguchi H and Yamada K: Roles of matrix metalloproteinases and their targets in epileptogenesis and seizures. Clinical Psychopharmacology and Neuroscience, 2013, 11:45-1152.
    3. Miyazaki M, Noda Y, Mouri A, Kobayashi K, Mishina M, Nabeshima N, Yamada K: Role of convergent activation of glutamatergic and dopaminergic systems in the nucleus accumbens in the development of methamphetamine psychosis and dependence. International Journal of Neuropsychopharmacology, 2013, 16(6):1341-1350.
    4. Yun J, Nagai T, Furukawa-Hibi Y, Kuroda K, Kaibuchi K and Yamada K: Neuronal Per Arnt Sim (PAS) domain protein 4 (Npas4) regulates neurite outgrowth and phosphorylation of synapsin I. Journal of Biological Chemistry, 2013, 288: 2655-2664.
    5. Ibi D, Nagai T, Nakajima A, Mizoguchi H, Kawase T, Tsuboi D, Kano S, Sato Y, Hayakawa M, Lange UC, Adams DJ, Surani MA, Satoh T, Sawa A, Kaibuchi K, Nabeshima T and Yamada K: Astroglial IFITM3 mediates neuronal impairments following neonatal immune challenge in mice. Glia, 2013, 61: 679-693, .
    6. Alkam,T, Kim HC, Hiramatsu M, Mamiya T, Aoyama Y, Nitta A, Yamada K and Nabeshima T: Evaluation of emotional behaviors in young offspring of C57BL/6J mice after gestational and/or perinatal exposure to nicotine in six different time-windows. Behavioural Brain Research, 2013, 239:80-89.
    7. Zhang L, Nagai T, Yamada K, Ibi D, Ichihara S, Suburamanian K, HuangZ, Mohideen SS, Naito H and Ichihara G.: Effects of sub-acute and sub-chronic inhalation of 1-bromopropane on neurogenesis in adult rats. Toxicology, 2013, 304:76-82.
    8. Yan Y, Miyamoto Y, Nitta A, Muramatsu S, Ozawa K, Yamada K and Nabeshima T: Intrastriatal gene delivery of GDNF persistently attenuates methamphetamine self-administration and relapse in mice. International Journal of Neuropsychopharmacology, 2013, 16:1559-1567.
    9. Nakajima A, Aoyama Y, Nguyen TTL, Shin EJ, Kim HC, Yamada S, Nakai T, Nagai T, Yokosuka A, Mimaki Y, Ohizumi Y and Yamada K: Nobiletin, a citrus flavonoid, ameliorates cognitive impairment, oxidative burden, and hyperphosphorylation of tau in senescence-accelerated mouse. Behavioural Brain Research, 2013, 250:351-360.
    10. Alkam T, Kim HC, Mamiya T, Yamada K, Hiramatsu M and Nabeshima T: Evaluation of cognitive behaviors in young offspring of C57BL/6J mice after gestational nicotine exposure during different time-windows. Psychopharmacology, 2013, 230:451-463.
    11. Toriumi K, Miki I, Kondo M, Mouri A, Koseki T, Ibi D, Hurukawa-Hibi Y, Nagai T, Mamiya T, Nitta A, Yamada K and Nabeshima T: SHATI/NAT8L regulates neurite outgrowth via microtubule stabilization. Journal of Neuroscience Research, 2013, 91:1525-1532.

    受賞

    1. 永井　拓准教授「平成25年度日本薬学会東海支部学術奨励賞」
      研究題目 「精神発達に及ぼす遺伝－環境因子の影響に関する研究」

    2012年研究業績

    原著論文（欧文）

    1. Tran HY, Shin EJ, Saito K, Nguyen XK, Chung YH, Jeong JH, Bach JH, Park DH, Yamada K, Nabeshima T, Yoneda Y, Kim HC.: Protective potential of IL-6 against trimethyltin-induced neurotoxicity in vivo. Free Radical Biology, 2012, 52:1159-1174.
    2. Takuma K, Mizoguchi H, Funatsu Y, Hoshina Y, Himeno Y, Fukuzaki E, Kitahara Y, Arai S, Ibi D, Kamei H, Matsuda T, Koike K, Inoue M, Nagai T and Yamada K: Combination of chronic stress and ovariectomy causes conditioned fear memory deficits and hippocampal cholinergic neuronal loss in mice. Neuroscience, 2013, 207:261-273.
    3. Mouri A, Sasaki A, Watanabe K, Sogawa C, Kitayama S, Mamiya M, Miyamoto Y, Yamada K, Noda Y and Nabeshima T: MAGE-D1 regulates expression of depression-like behavior through serotonin transporter ubiquitylation. Journal of Neuroscience, 2012, 28:4562-4580.
    4. Yan Y, Nitta A, Koseki T, Yamada K, Nabeshima T: Dissociable role of tumor necrosis factor alpha gene deletion in methamphetamine self-administration and cue-induced relapsing behavior in mice. Psyhopharmacology, 2012, 221: 427-436.
    5. Jin D, Muramatsu S, Shimizu N, Yokoyama S, Hirai K, Yamada K, Liu H-X, Higashida C, Hashii M, Higashida A, Asano M, Ohkuma S and Higashida H: Dopamine release via the vacuolar ATPase V0 sector c-subunit, confirmed in N18 neuroblastoma cells, results in behavioral recovery in hemiparkinsonian mice. Neurochemistry International, 2012, 61:907-912.
    6. Nakamoto K, Kawasaki S, Kobori T, Fujita-Hamabe W, Mizoguchi H, Yamada K, Nabeshima T, Tokuyama S: Involvement of matrix metalloproteinase-9 in the development of morphine tolerance. European Journal of Pharmacology, 2012, 683:86-92.
    7. Nakajima A, Kinugasa Y, Torii J, Hishinuma T, Tomioka Y, Yamada K , Yamakuni T: Repeated treatment with nicotine induces phosphorylation of NMDA receptor NR2B subunit in the brain regions involved in behavioral sensitization. Neuroscience Letters, 2012, 524:133-138.
    8. Takuma K, Mizoguchi H,Funatsu Y, Kitahara Y, Ibi D, Kamei H, Matsuda T, KoikeK, Inoue M, Nagai T, Yamada K: Placental extract improves hippocampal neuronal loss and fear memory impairment resulting from chronic restraint stress in ovariectomized mice. Journal of Pharmacological Sciences, 2012, 120:89-97,.
    9. Furukawa-Hibi Y, Nitta A, Fukumitsu H, Somiya H, Toriumi K, Furukawa S, Nabeshima T and Yamada K: Absence of SHATI/Nat81 reduces social interaction in mice. Neuroscience Letters, 2012, 526:79-84.
    10. Nagai T, Yu J, Kitahara Y, Nabeshima T and Yamada K: D-serine ameliorates neonatal polyI:C treatment-induced emotional and cognitive impairments in adult mice. Journal of Pharmacological Sciences, 2012, 120:213-227.
    11. Furukawa-Hibi Y, Yun J, Nagai T and Yamada K.: Transcriptional suppression of the neuronal PAS domain 4 (Npas4) gene by stress via the binding of agonist-bound glucocorticoid receptor to its promoter. Journal of Neurochemistry, 2012, 123:866-875.

    受賞

    1. 永井　拓准教授「日本神経精神薬理学会 第1回日本神経精神薬理学会学術奨励賞」
      研究題目」「ドパミン作動性およびグルタミン酸作動性神経伝達の変調と障害に関する神経精神薬理学的研究」

    2011年研究業績

    原著論文（欧文）

    1. Mizoguchi H, Ibi D, Takase F, Nagai T, Kamei H, Toth E, Sato J, Takuma K and Yamada K: Nicotine ameliorates impairment of working memory in methamphetamine-treated rats. Behavioural Brain Research, 2011, 220:159-163.
    2. Alkam T, Hiramatsu M, Mamiya T, Aoyama Y, Nitta A, Yamada K, Kim HC and Nabeshima T: Evaluation of object-based attention in mice. Behavioural Brain Research, 2011, 220:185-193.
    3. Shin EJ, Kim JM, Nguyen XKT, Nguyen TTL, Lee SY, Jung JH, Kim MJ, Whang WK, Yamada K, Nabeshima T and Kim HC: Effect of Gastrodia Elata Bl on phencyclidine-induced schizophrenia-like psychosis in mice. Current Neuropharmacology, 2011, 9:247-250.
    4. Wakasaya Y, Kawarabayashi T, Watanabe M, Yamamoto-Watanabe Y, Takamura A, Kurata T, Murakami T, Abe K, Yamada K, Wakabayashi K, Sasaki A, Westaway D, Hyslop PG, Matsubara E, Shoji M: Factors responsible for neurofibrillary tangles and neuronal cell losses in tauopathy. Journal of Neuroscience Research, 2011, 89:576-584.
    5. Furukawa-Hibi Y, Nitta A, Ikeda T, Morishita K, Liu W, Ibi D, Alkam T, Nabeshima T and Yamada K: The hydrophobic dipeptide Leu-Ile inhibits immobility induced by repeated forced swimming via the induction of BDNF. <strong><span>Behavioural Brain Research, 2011, 220: 271-280.
    6. Shichi K, Fujita-Hamabe W, Harada S, Mizoguchi H, Yamada K, Nabeshima T and Tokuyama S: Involvement of matrix metalloproteinase-mediated proteolysis of neuronal cell adhesion molecule in the development of cerebral ischemic neuronal damage. Journal of Pharmacology and Experimental Therapeutics, 2011, 338:701-710.
    7. Furukawa-Hibi Y, Alkam T, Nitta A, Matsuyama A, Mizoguchi H, Suzuki K, Moussaoui S, Yu Q-S, Greig NH, Nagai T and Yamada K: Butyrylcholinesterase inhibitors ameliorate cognitive dysfunction induced by amyloid-s peptide in mice. Behavioural Brain Research, 2011, 225:222-229.
    8. Nagai T, Kitahara Y, Ibi D, Nabeshima T, Sawa A and Yamada K: Effects of antipsychotics on the behavioral deficits in human dominant-negative DISC1 transgenic mice with neonatal polyI:C treatment. Behavioural Brain Research, 2011, 225:305-310.
    9. Mizoguchi H, Nakade J, Tachibana M, Ibi D, Someya E, Koike H, Kamei H, Nabeshima T, Itohara S, Takuma K, Sawada M, Sato J and Yamada K: Matrix metalloproteinase-9 contributes to kindlined seizure development in pentylenetetrazole-treated mice by converting pro-BDNF to mature BDNF in the hippocampus. Journal of Neuroscience, 2011, 31:12963-12971.
    10. Kuroda K, Yamada S, Tanaka, Iizuka M, Yano H, Mori D, Tsuboi D, Nishioka T, Namba T, Iizuka Y, Kubota S, Nagai T, Ibi D, Wang R, Enomoto A, Isotani-Sakakibara M, Asai N, Kimura K, Kiyonari H, Abe T, Mizoguchi A, Sokabe M, Takahashi M, Yamada K and Kaibuchi K: Behavioral alterations associated with targeted disruption of exons 2 and 3 of the DISC1 gene in the mouse. Human Molecular Genetics, 2011, 20, 4666-4683.
    11. Mizoguchi H, Yamada K and Nabeshima T: Matrix metalloproteinases contribute to neuronal dysfunction in animal models of drug dependence, Alzheimer's disease, and epilepsy. Biochemistry Research International, 2011, 2011:681385.

    総説論文（欧文）

    1. Mizoguchi H. and Yamada K: Pharmacologic treatment with GABAB receptor agonist on methamphetamine-induced cognitive impairment in mice. Current Neuropharmacology, 2011, 9, 109-112.
    2. Yamada K: Translational research in neurodevelopmental disorders: Development of etiology-based animal models. Biological & Pharmaceutical Bulletin, 2011, 34(9), 1357.
    3. Nagai T, Ibi D and Yamada K: Animal model for schizophrenia that reflects gene-environment interactions. Biological & Pharmaceutical Bulletin, 2011, 34(9), 1364-1368.

    受賞

    1. 水野 智博大学院生「日本薬学会132年会 学生優秀発表賞」
      発表タイトル「新規KDIGO基準による急性腎障害の頻度と臨床アウトカムの評価」
    2. Jaesuk Yun大学院生「第2回アジア神経精神薬理学会(AsCNP)ソウル大会 JSNP JSNP Excellent Presentation Award for AsCNP2011 Seoul」
      発表タイトル「The role of Npas4 in neurite outgrowth and phosphorylation of synapsin Ⅰ
    3. 日比 陽子特任助教「第3回NAGOYAグローバルリトリート 最優秀口演賞」
      発表タイトル「Stress regulates the expression of n neuronal PAS dom main 4 (NPAS4)」

    2010年研究業績

    原著論文（欧文）

    1. Ibi D, Nagai T, Koike H, Kitahara Y, Mizoguchi H, Niwa M, Jaaro-Peled H, Nitta A, Yoneda Y, Nabeshima T, Sawa A, and Yamada K: Combined effect of neonatal immune activation and mutant DISC1 on phenotypic changes in adulthood. Behavioural Brain Research, 2010, 206, 32-37.
    2. Nagai T, Kitahara Y, Shiraki A, Hikita T, Taya S, Kaibuchi K and Yamada K: Dysfunction of dopamine release in the prefrontal cortex of dysbindin deficient sandy mice: an in vivo microdialysis study. Neuroscience Letters, 2010, 470:134-138.
    3. Lu P, Mamiya T, Lu L, Mouri A, Niwa M, Kim HC, Zou LB, Nagai T, Yamada K, Ikejima T, Nabeshima T.: Silibinin attenuates cognitive deficits and decreases of dopamine and serotonin induced by repeated methamphetamine treatment. Behavioural Brain Research, 2010, 207:387-393.
    4. Ohki M, Ohki Y, Ishihara M, Nishida C, Tashiro Y, Akiyama H, Komiyama H, Lund LR, Nitta A, Yamada K, Zhu Z, Ogawa H, Yagita H, Okumura K, Nakauchi H, Werb Z, Heissig B, and Hattori K: Tissue type plasminogen activator regulates myeloid-cell dependent neoangiogenesis during tissue regeneration. Blood, 115:4302-4312, 2010.
    5. Katsuno M, Adachi H, Minamiyama M, Waza M, Tokui K, Doi H, Mizoguchi H, Nitta A, Yamada K, Banno H, Suzuki K, Tanaka F, and Sobue G: Disrupted TGF-beta signaling in spinal and bulbar muscular atrophy. Journal of Neuroscience, 2010, 30:5702-5712.
    6. Alkam T, Nitta A, Furukawa-Hibi Y, Niwa M, Mizoguchi H, Yamada K, and Nabeshima T.: Oral supplementation with Leu-Ile, a hydrophobic dipeptide, prevents the impairment of memory induced by amyloid beta in mice via restraining the hyperphosphorylation of extracellular signal-regulated kinase. Behavioural Brain Research, 2010, 210:184-190.
    7. Yu J, Nagai T, Ibi D, Kitahara Y, Nabeshima T and Yamada K.: Nicotine ameliorates emotional and cognitive impairments induced by neonatal polyI:C treatment in mice. The Open Behavioral Science Journal, 2010, 4: 9-18.
    8. Mizoguchi H, Ibi D, Takuma K, Toth E, Sato J, Itohara S, Nabeshima N and Yamada K.: Alterations of emotional and cognitive behaviors in matrix metalloproteinase-2 and -9-deficient mice. The Open Behavioral Science Journal, 2010, 4: 19-25.
    9. Yun J, Koike H, Ibi D, Toth E, Mizoguchi H, Nitta A, Yoneyama M, Ogita K, Yoneda Y, Nabeshima T, Nagai T and Yamada K: Chronic restraint stress impairs neurogenesis and hippocampus-dependent fear memory in mice: a possible involvement of a brain specific transcription factor Npas4. Journal of Neurochemistry, 2010, 114:1840-1851.
    10. Shin EJ, Whang WK, Kim S, Bach JH, Kim JM, Nguyen XKT, Nguyen TTL, Jung BD, Yamada K, Nabeshima T and and Kim HC: Parshin C attenuate phencyclidine-induced schizophrenia-like psychosis in mice: involvement of 5-HT1A receptor. Journal of Pharmacological Sciences, 2010, 113:404-408.
    11. Furukawa-Hibi Y, Nitta A, Fukumitsu H, Somiya H, Furukawa S, Nabeshima T and Yamada K: Overexpression of piccolo C2A domain induces depression-like behavior in mice. Neuroreport 21:1177-1181, 2010.
    12. Noda Y, Mouri A, Ando Y, Waki Y, Yamada SN, Yoshimi A, Yamada K, Ozaki N, Wang D, Nabeshima T.: Galantamine ameliorates the impairment of recognition memory in mice repeatedly treated with methamphetamine: involvement of allosteric potentiation of nicotinic acetylcholine receptors and dopaminergic-ERK1/2 systems. International Journal of Neuropsychopharmacology, 2010, 13: 1343-1354.

    2009年研究業績

    原著論文（欧文）

    1. Arai S, Takuma K, Mizoguchi H, Ibi D, Nagai T, Kamei H, Kim H.C. and Yamada K: GABAB receptor agonist baclofen improve methamphetamine-induced cognitive deficit in mice. European Journal of Pharmacology, 2009, 602, 101-104.
    2. Villard V, Espallergues J, Keller E, Alkam T, Nitta A, Yamada K, Nabeshima, T, Vamvakides A and Maurice T: Anti-amnesic and neuroprotective effects of the aminotetrahydrofuran derivative ANAVEX1-41 against amyloid β25-35 -induced toxicity in mice. Neuropsychopharmacology,34, 1552-1566, 2009.
    3. Shin EJ, Chae JS, Park SJ, Kim SC, Koo KH, Yamada K, Nabeshima T and Kim HC: Growth hormone-releaser attenuates β-amyloid (1-42)-induced cognitive impairment via stimulation of the insulin-like growth factor (IGF) -1 receptor in mice. Journal of Pharmacological Sciences, 2009, 109, 139-143.
    4. Gu B, Nakamichi N, Zhang WS, Nakamura Y, Kambe Y, Fukumori R, Takuma K, Yamada K, Takarada T, Taniura H, Yoneda Y: Possible protection by notoginsenoside R1 against glutamate neurotoxicity mediated by N-methyl-D-aspartate receptors composed of an NR1/NR2B subunit assembly. Journal of Neuroscience Research, 2009, 87, 2145-2156.
    5. Koike H, Ibi D, Mizoguchi H, Nagai T, Nitta A, Takuma K, Nabeshima T, Yoneda Y and Yamada K: Behavioral abnormality and pharmacologic response in social isolation-reared mice. Behavioural Brain Research, 2009, 202, 114-121.
    6. Ibi D, Nagai T, Kitahara Y, Mizoguchi H, Koike H, Shiraki A, Takuma K, Kamei H, Noda N, Nitta A, Nabeshima T, Yoneda Y and Yamada K: Neonatal polyI:C treatment in mice results in schizophrenia-like behavioral and neurochemical abnormalities in adulthood. Neuroscience Research, 2009, 64, 297-305.
    7. Kimura H, Yukitake H, Suzuki H, Tajima Y, Koyo Gomaibashi K, Morimoto S, Funabashi Y, Yamada K and Takizawa M.: A Chondroprotective Agent ITZ-1 Inhibits IL-1β-Induced MMP-13 Production and Suppresses NO-Induced Chondrocyte Death. Journal of Pharmacological Sciences, 2009, 110, 201-211.
    8. Shin EJ, Bing G, Chae JS, Kim TW, Bach JH, Park DH, Yamada K, Nabeshima T and Kim HC: Role of microsomal epoxide hydrolase in the methamphetamine-induced drug dependence in mice. Journal of Neuroscience Research, 2009, 87, 3679-3686.
    9. Jin CH, Shin EJ, Park JB, Jang CG, Li Z, Kim MS, Koo KH, Yoon HJ, Park SJ, Choi WC, Yamada K, Nabeshima T and Kim HC: Fustin flavonoid attenuates β-amyloid (1-42)-induced learning impairment. Journal of Neuroscience Research, 87, 3658-3670, 2009.
    10. Shin EJ, Jang CG, Bing G, Park DH, Oh CH, Koo KH, Oh KW, Yamada K, Nabeshima T and Kim HC: Prodynorphin gene deficiency potentiates nalbuphine-induced behavioral sensitization and withdrawal syndrome in mice. Drug Alcohol Dependence, 2009, 104, 175-184.
    11. Mizoguchi H, Takuma K, Fukuzaki E, Ibi D, Someya E, Akazawa K, Alkam T, Tsunekawa H, Mouri A, Noda Y, Nabeshima T and Yamada K: Matrix metalloprotease-9 inhibition improves amyloid β-mediated cognitive impairment and neurotoxicity in mice. Journal of Pharmacology and Experimental Therapeutics, 2009, 331, 14-22.
    12. Otsuka N, Tsuritani K, Sakurai T, Kato K, Matoba R, Itoh J, Okuyama S, Yamada K and Yoneda Y. Transcriptional induction and translational inhibition of Arc and Cugbp2 in mice hippocampus after transient global ischemia under normothermic condition. Brain Research, 2009, 1287, 136-145.
    13. Mizoguchi H, Arai S, Koike H, Ibi D, Kamei H, Nabeshima T, Kim HC, Takuma K and Yamada K: Therapeutic potential of nicotine for methamphetamine-induced impairment of sensorimotor gating: involvement of pallidotegmental neurons. Psychopharmacology, 2009, 207:235-243.
    14. Takuma K, Fang F, Zhang W, Yan S, Fukuzaki E, Du H, Sosunov A, McKann G, Funatsu Y, Nakamichi N, Nagai T, Mizoguchi H, Ibi D, Hori O, Ogawa S, Stern DM, Yamada K and Yan SD: RAGE-mdiated signaling contributes to intraneuronal transport of amyloid-β and neuronal dysfunction. Proceedings of the National Academy of Sciences, 12009, 06, 20021-20026.

    その他研究成果

    厚生労働科学研究費補助金（化学物質リスク総合研究事業）

    1. 周産期における異常免疫応答による神経精神毒性に関する研究　分担研究者：山田　清文
    2. 新生仔期にpolyriboinosinic-polyribocytidilic acid(polyI:C)を投与したマウスの海馬におけるタンパク発現の変化　分担研究者：永井　拓

    2008年研究業績

    原著論文（欧文）

    1. Mizoguchi H, Takuma K, Fukakusa A, Ito Y, Nakatani A, Ibi D, Kim HC and Yamada K: Improvement by minocycline of methamphetamine-induced impairment of recognition memory in mice. Psychopharmacology (Berl), 2008, 196, 233--41.
    2. Fukakusa A, Nagai T, Mizoguchi H, Otsuka N, Kimura H, Kamei H, Kim H-C, Nabeshima T, Takuma K and Yamada K: Role of tissue plasminogen activator in the sensitization of methamphetamine-induced dopamine release in the nucleus accumbens. Journal of Neurochemistry, 2008, 105, 436-444.
    3. Ibi D, Takuma K, Koike H, Mizoguchi H, Tsuritani K, Kuwahara Y, Kamei H, Nagai T, Yoneda Y, Nabeshima T and Yamada K: Social isolation rearing-induced impairment of the hippocampal neurogenesis is associated with deficits in spatial memory and emotion-related behaviors in juvenile mice. Journal of Neurochemistry, 2008, 105, 921-932.
    4. Fukakusa A, Mizoguchi H, Koike H, Nabeshima T, Takuma K and Yamada K: Tissue plasminogen activator is not involved in methamphetamine-induced neurotoxicity. Journal of Pharmacological Sciences, 2008, 106, 321-324,.
    5. Fukuzaki E, Takuma K, Himeno Y, Yoshida S, Funatsu Y, Kitahara Y, Mizoguchi H, Ibi D, Koike K, Inoue M and Yamada K: Enhanced activity of hippocampal BACE1 in a mouse model of postmenopausal memory deficits. Neuroscience Letters, 2008, 433, 141-145.
    6. Alkam T, Nitta A, Mizoguchi H, Saito K, Seshima M, Itoh A, Yamada K and Nabeshima T: Restraining tumor necrosis factor-alpha by thalidomide prevents the Abeta-induced impairment of recognition memory in mice. Behavioural Brain Research, 2008, 189, 100-106.
    7. Tamaki K, Yamada K, Nakamichi N, Taniura H and Yoneda Y: Transient suppression of progenitor cell proliferation through NMDA receptors in hippocampal dentate gyrus of mice with traumatic stress experience. Journal of Neurochemistry, 2008, 105, 1642-1655, .
    8. Kawanokuchi J, Shimizu K, Nitta A, Yamada K, Mizuno T, Takeuchi H and Suzumura A: Production and functions of IL-17 in microglia. Journal of Neuroimmunology, 2008, 194, 54-61.
    9. Fukuzaki E, Takuma K, Funatsu Y, Himeno Y, Kitahara Y, Gu B, Mizoguchi H, Ibi D, Koike K, Inoue M, Yan SD and Yamada K: Ovariectomy increases neuronal amyloid ? binding alchohol dehydrogenease level in the mouse hippocampus. Neurochemistry International, 2008, 52, 1358-1364.
    10. Alkam T, Nitta A, Mizoguchi H, Itoh A, Murai R, Nagai T, Yamada K and Nabeshima T: The extensive nitration of neurofilament light chain in the hippocampus is associated with the cognitive impairment induced by amyloid β in mice. The journal of pharmacology and experimental therapeutics, 2008, 327, 137-147.
    11. Yano K, Yamamura K, Osada T, Fukase F, Kiriyama N, Torimoto M, Yamada K, Kishi DT and Nabeshima T: Documenting the value of a pharmacist-managed anticoagulation classroom. Journal of Applied Therapeutic Research, 2008, 6, 41-48.
    12. Arai S, Takuma K, Mizoguchi H, Ibi D, Nagai T, Takahashi K, Kamei H, Nabeshima T and Yamada K: Involvement of pallidotegmental neurons in methamphetamine- and MK-801-induced impairment of prepulse inhibition of the acoustic startle reflex in mice: reversal by GABAB receptor agonist baclofen. Neuropsychopharmacology 33, 3164-3175, 2008.
    13. Niwa M, Nitta A, Cen X, Kitaichi K, Ozaki N, Yamada K and Nabeshima T: A novel molecule 'shati' increases dopamine uptake via the induction of tumor necrosis factor-α| in pheochromocytoma-12 cells. Journal of Neurochemistry, 2008, 107, 1697-1708.
    14. Kanazawa Y, Makino M, Morishima Y, Yamada K, Nabeshima T, Shirasaki Y: Degradation of PEP-19, a calmodulin-binding protein, by calpain is implicated in neuronal cell death induced by intracellular Ca2+ overload. Neuroscience 154, 473-81, 2008.

    総説論文（欧文）

    1. Yamada K and Kaneko S: Neuropsychotoxicity of abused drugs: Clinical and basic research and drug developmen. Journal of Pharmacological Sciences, 106, 1, 2008.
    2. Nagai T, Nabeshima T and Yamada K: Basic and translational research on proteinase-activated receptors: Regulation of nicotine reward by the tissue plasminogen activator (tPA)-plasmin system via proteinase-activated receptor 1. Journal of Pharmacological Sciences, 108, 4048-414, 2008.
    3. Mizoguchi H, Yamada K and Nabeshima T: Neuropsychotoxicity of Abused Drugs: Involvement of matrix metalloproteinase-2 and -9, and tissue inhibitor of matrix metalloproteinase-2 in methamphetamine-induced behavioral sensitization and reward in rodents. ournal of Pharmacological Sciences, 2008, 106, 9-14.
    4. Yamada K: Role for anti-addictive and pro-addictive factor in drug dependence. Nagoya Journal of Medical Science, 2008, 70, 67-72, 2008.
    5. Yamada K: Endogenous modulators for drug dependence. Biological & Pharmaceutical Bulletin, 2008, 31, 1635-1638.

    その他研究成果

    厚生労働科学研究費補助金（化学物質リスク総合研究事業）

    1. 周産期における異常免疫応答による神経精神毒性に関する研究　分担研究者：山田　清文
    2. 新生仔期にpolyriboinosinic-polyribocytidilic acid(polyI:C)を投与したマウスの海馬におけるタンパク発現の変化　分担研究者：永井　拓

    2007年研究業績

    原著論文（欧文）

    1. Ito Y, Takuma K, Mizoguchi H, Nagai T and Yamada K: A novel azaindolizinone derivative ZSET1446 (spiro[imidazo[1,2-a]pyridine-3,2-indan]-2(3H)-one) improves methamphetamine-induced impairment of recognition memory in mice by activating extracellular signal-regulated kinase 1/2. The journal of pharmacology and experimental therapeutics, 2007, 320, 819-827.
    2. Mizoguchi H, Yamada K, Niwa M, Mouri A, Mizuno T, Noda Y, Nitta A, Itohara S, Banno Y and Nabeshima T: Reduction of methamphetamine-induced sensitization and reward in matrix metalloproteinase-2 and -9 deficient mice. Journal of Neurochemistry, 2007, 100, 1579-1588.
    3. Takahashi K, Nagai T, Kamei H, Maeda K, Matsuya T, Arai S, Mizoguchi H, Yoneda Y, Nabeshima T, Takuma K and Yamada K: Neural circuits containing pallidotegmental GABAergic neurons are involved in the prepulse inhibition of the startle reflex in mice. Biological Psychiatry, 2007, 62, 148-157.
    4. Jin D, Liu HX, Hirai H, Torashima T, Nagai T, Lopatina O, Shnayder NA, Yamada K, Noda M, Seike T, Fujita K, Takasawa S, Yokoyama S, Koizumi K, Shiraishi Y, Tanaka S, Hashii M, Yoshihara T, Higashida K, Islam MS, Yamada N, Hayashi K, Noguchi N, Kato I, Okamoto H, Matsushima A, Salmina A, Munesue T, Shimizu N, Mochida S, Asano M and Higashida H: CD38 is critical for social behaviour by regulating oxytocin secretion. Nature, 2007, 446, 41-45.
    5. Yan Y, Yamada K, Nitta A and Nabeshima T: Transient drug-primed but persistent cue-induced reinstatement of extinguished methamphetamine-seeking behavior in mice. Behavioural Brain Research, 2007, 177, 261-268.
    6. Ito M, Nagai T, Mizoguchi H, Fukakusa A, Nakanishi Y, Kamei H, Nabeshima T, Takuma K and Yamada K: Possible involvement of protease-activated receptor-1 in the regulation of morphine-induced dopamine release and hyperlocomotion by the tissue plasminogen activator-plasmin system. Journal of Neurochemistry, 2007, 101, 1392-1399.
    7. Nagai T, Takuma K, Kamei H, Ito Y, Nakamichi N, Ibi D, Nakanishi Y, Murai M, Mizoguchi H, Nabeshima T and Yamada K: Dopamine D1 receptors regulate protein synthesis-dependent long-term recognition memory via extracellular signal-regulated kinase 1/2 in the prefrontal cortex. Learning & Memory, 2007, 14, 117-125.
    8. Takuma K, Matsuo A, Himeno Y, Hoshina Y, Ohno Y, Funatsu Y, Arai S, Kamei H, Mizoguchi H, Nagai T, Koike K, Inoue M and Yamada K: 17β-Estradiol attenuates hippocampal neuronal loss and cognitive dysfunction induced by chronic restraint stress in ovariectomized rats. Neuroscience, 2007, 146, 60-68.
    9. Yan Y, Yamada K, Mizoguchi H, Noda Y, Nagai T, Nitta A and Nabeshima T: Reinforcing effects of morphine are reduced in tissue plasminogen activator (tPA)-knockout mice. Neuroscience, 2007, 146, 50-59.
    10. Maeda K, Sugino H, Hirose T, Kitagawa H, Nagai T, Mizoguchi H, Takuma K and Yamada K: Clozapine prevents a decrease in neurogenesis in mice repeatedly treated with phencyclidine. Journal of Pharmacological Sciences, 2007, 103, 299-308.
    11. Matsuya T, Takuma K, Sato K, Asai M, Murakami Y, Miyoshi S, Noda A, Nagai T, Mizoguchi H, Nishimura S and Yamada K: Synergistic effects of adenosine A2A antagonist and L-DOPA on rotational behaviors in 6-Hydroxydopamine-induced hemi-Parkinsonian mouse model. Journal of Pharmacological Sciences, 2007, 103, 329-332.
    12. Yan Y, Yamada K, Niwa M, Nagai T, Nitta A and Nabeshima T: Enduring vulnerability to reinstatement of methamphetamine-seeking behavior in glial cell line-derived neurotrophic factor mutant mice. FASEB Journal. 2007, 21, 1994-2004.
    13. Mizoguchi H, Yamada K, Mouri A, Niwa M, Mizuno T, Noda Y, Nitta A, Itohara S, Banno Y and Nabeshima T: Role of matrix metalloproteinase and tissue inhibitor of MMP in methamphetamine-induced behavioral sensitization and reward: implication for dopamine receptor down-regulation and dopamine release. Journal of Neurochemistry, 2007, 102, 1548-1560.
    14. Nagai T, Takuma K, Dohniwa M, Ibi D, Mizoguchi H, Kamei H, Nabeshima T and Yamada K: Repeated methamphetamine treatment impairs spatial working memory in rats: reversal by clozapine but not haloperidol. Psychopharmacology (Berl), 2007, 194, 21-32.
    15. Takuma K, Hoshina, Y, Arai S, Himeno Y, Matsuo, A, Funatsu Y, Kitahara Y, Ibi, D, Hayase M, Kamei H, Mizoguchi H, Nagai T, Koike K, Inoue M and Yamada K: Ginkgo biloba extract EGb761 attenuates hippocampal neuronal loss and cognitive dysfunction resulting from chronic restraint stress in ovariectomized rats. Neuroscience, 2007, 149, 256-262.
    16. Takano K, Kitao Y, Tabata Y, Miura H, Sato K, Takuma K, Yamada K, Hibino S, Choshi T, Iinuma M, Suzuki H, Murakami R, Yamada M, Ogawa S and Hori O: A dibenzoylmethane (DBM) derivative protects dopaminergic neurons against both oxidative stress and endoplasmic reticulum (ER) stress. American Journal of Physiology-Cell Physiology, 2007, 293, 1884-1894.
    17. Ito M, Nagai T, Mizoguchi H, Sato K, Hayase M, Otsuka N, Fukakusa A, Kumagai N, Kim H-C, Nabeshima T, Takuma K and Yamada K: Activation of post-synaptic dopamine D1 receptors promotes the release of tissue plasminogen activator in the nucleus accumbens via PKA signaling. Journal of Neurochemistry, 2007, 103, 2589-2596.
    18. Shin EJ, Jeong JH, Kim HJ, Jang CG, Yamada K, Nabeshima T and Kim HC: Exposure to extremely low frequency magnetic fields enhances locomotor activity via activation of dopamine D1-like receptors in mice. Journal of Pharmacological Sciences, 2007, 105, 367-371.

    総説論文（欧文）

    1. Niwa M, Nitta A, Yamada K and Nabeshima T: The roles of glial cell line-derived neurotrophic factor, tumor necrosis factor and an inducer of these factors in drug dependence. Journal of Pharmacological Sciences, 2007, 104, 116-121.
    © Nagoya University School of Medicine. All Rights Reserved.