名古屋大学大学院医学研究科 医療薬学・医学部附属病院薬剤部

医療薬学研究室紹介

研究業績

34th CINP World Congress Neuropsychopharmacology Dong Geyao大学院生の成果

JSNP Excellent Presentation Award for CINP 2023　受賞タイトル「Comprehensive Phosphoproteomic Analysis in Reelin Mutant Mice Identified Crucial Role Of Twinfilin1 in Spine Development And Actin Dynamics.」

第142回日本薬理学会近畿部会　朱　悠韻大学院生の成果

第142回日本薬理学会近畿部会優秀発表賞　タイトル「Neuronal morphological impairments in the model mice carrying the same deletion of RELN gene that was identified in a Japanese schizophrenia patient.」

第141回日本薬理学会近畿部会　Dong Geyao大学院生の成果

第141回日本薬理学会近畿部会最優秀発表賞　タイトル「Phosphorylation of twinfilin-1 involved in the reelin signaling plays a crucial role in spine development」

7th Congress of AsCNP 2021　田中　里奈子大学院生の成果

JSNP Excellent Presentation Awerd for AsCNP 2021及び鍋島賞受賞　タイトル「「Effect of a Rho-kinase inhibitor, fasudil, on spine density in the mPFC of mice carrying a mutation of the Arhgap10 gene」

The 23rd Korea-Japan Joint Seminar on Pharmacology　田中　里奈子大学院生の成果

ePoster Best Presentation Award受賞、タイトル「Effect of fasudil in a pharmacologic animal model of schizophrenia」

東海国立大学機構融合フロンティア次世代研究事業の採択

田中　里奈子大学院生が2021年10月1日～2023年3月　東海国立大学機構融合フロンティア次世代リサーチャー事業の東海国立大学機構融合フロンティア次世代リサーチャー（バイオサイエンス分野）に認定されました。

第133回薬理学会近畿部会　羽田　和弘大学院生の成果

平成30年度

  1. 新規統合失調症関連遺伝子ARHGAP10変異マウスの行動薬理学的・神経科学的解析

日本病院薬剤師会東海ブロック・日本薬学会東海支部 合同学術大会2015　宮崎　雅之主任の成果

平成27年度

  1. 小児患者の移植前処置におけるブスルファン血中濃度による投与量設定の取り組み

平成25年度日本薬学会東海支部　永井　拓　准教授の成果

平成25年度

  1. 精神発達に及ぼす遺伝ー環境因子の影響に関する研究

第1回日本神経精神薬理学会学術奨励賞　永井　拓 准教授の成果

平成24年度

  1. ドパミン作動性およびグルタミン酸作動性神経伝達の変調と障害に関する神経精神薬理学的研究

第132回日本薬学会　水野　智博 大学院生の成果

平成23年度

  1. 新規KDIGO基準によるシスプラチン急性腎不全の重症度分類は患者の生命予後を反映する

第2回アジア神経精神薬理学会（AsCNP）ソウル大会　尹 錫在 大学院生の成果

平成23年度
  1. The role of Npas4 in neurite outgrowth and phosphorylation of synapsin Ⅰ

第3回NAGOYAグローバルリトリート 日比 陽子 特任助教の成果

平成22年度

  1. Stress regulates the expression of neuronal PAS domain 4(NPAS4)

化学物質リスク研究事業(厚生労働科学研究費補助金、主任研究者：鍋島俊隆)の成果

平成21年度

  1. 周産期における異常免疫応答による神経精神毒性に関する研究　分担研究者：山田　清文
  2. 新生仔期にpolyriboinosinic-polyribocytidilic acid(polyI:C)を投与したマウスの海馬におけるタンパク発現の変化　分担研究者：永井　拓

平成20年度

  1. 周産期における異常免疫応答による神経精神毒性に関する研究　分担研究者：山田　清文
  2. 新生仔期にpolyriboinosinic-polyribocytidilic acid(polyI:C)を投与したマウスの海馬におけるタンパク発現の変化　分担研究者：永井　拓

原著（欧文）

2023年

  1. Tanaka R, Liao J, Hada K, Mori D, Nagai T, Matsuzaki T, Nabeshima T, Kaibuchi K, Ozaki N, Mizoguchi H, Yamada K. Inhibition of Rho-kinase ameliorates decreased spine density in the medial prefrontal cortex and methamphetamine-induced cognitive dysfunction in mice carrying schizophrenia-associated mutations of the Arhgap10 gene. Pharmacol Res. Jan;187:106589. (doi: 10.1016/j.phrs.2022.106589.)

2022年

  1. Takase S, Liao J, Liu Y, Tanaka R, Miyagawa Y, Sawahata M, Sobue A, Mizoguchi H, Nagai T, Kaibuchi K, Ozaki N, Yamada K. Antipsychotic-like effects of fasudil, a Rho-kinase inhibitor, in a pharmacologic animal model of schizophrenia. Eur J Pharmacol. Sep 15;931:175207. (doi: 10.1016/j.ejphar.2022.175207.)
  2. Wu Mengya, Funahashi Yasuhiro, Takano Tetsuya, Hossen Emran, Ahammad Rijwan Uddin, Tsuboi Daisuke, Amano Mutsuki, Yamada Kiyofumi, Kaibuchi Kozo. Rho-Rho-Kinase Regulates Ras-ERK Signaling Through SynGAP1 for Dendritic Spine Morphology. Neurochem Res. Sep;47(9):2757-2772. (doi: 10.1007/s11064-022-03623-y.)
  3. Tsuneura Y,Nakai T,Mizoguchi H,Yamada K. New Strategies for Treatment of Neuropsychiatric Disorders Based on Reelin Dysfunction. Int J Mol Sci. Feb 6;23(3):1829. (doi: 10.3390/ijms23031829.)
  4. Faruk,Mo,Tsuboi D,Yamahashi Y,Funahashi Y,Lin YH,TzingounisAV,Yamada K,NagaiT,kaibuchi K. Muscarinic signaling regulates voltage-gated potassium channel KCNQ2 phosphorylation in the nucleus accumbens via protein kinase C for aversive learning. J Neurochem. Feb;160(3):325-341. (doi: 10.1111/jnc.15555. )
  5. Liao,JZ,Dong,GY，Wulaer B,Sawahata M,Mizoguchi H,Mori D,Ozaki N,Nabeshima T,Nagai T,Yamada K. Mice with exonic RELN deletion identified from a patient with schizophrenia have impaired visual discrimination learning and reversal learning in touchscreen operant tasks. Behav Brain Res. Jan 7;416:113569. 2022. (doi: 10.1016/j.bbr.2021.113569. )

2021年

  1. Ahammad RU,Nishioka T,Yoshimoto J,Kannon T,Amano M,Funahashi Y,Tsuboi D,Faruk Mo,Yamahashi Y,Yamada K,Nagai T, Kaibuchi K. KANPHOS: A Database of Kinase-Associated Neural Protein hosphorylation in the Brain. Cells. Dec 24;11(1):47.2021. (doi: 10.3390/cells11010047.)
  2. Uchida M,Noda Y,Hasegawa S,Hida H,Taniguchi M,Mouri A,Yoshimi A,Nabeshima T,Yamada K,Aida T,Tanaka K,Ozaki N. Early postnatal inhibition of GLAST causes abnormalities of psychobehaviors and neuronal morphology in adult mice. Neurochem Int. Nov;150:105177. (doi: 10.1016/j.neuint.2021.105177.)
  3. Yoshimi A,Shiroma Y,Iwata M,Nakamura M,Torii-Goto A,Hida H,Tanaka N,Miyazaki M,Yamada K,Noda Y. Survey of chemotherapy-induced nausea and vomiting in patients eith urothelial carcinoma.Mol Clin Oncol. Oct;15(4):219. (doi: 10.3892/mco.2021.2384.)
  4. Sawahata M,AsanoH,Nagai T,Ito N,Kohno T,Nabeshima T,Hattori M,Yamada K. Microinjection of Reelin into the mPFC prevents MK-801-induced recognition memory impairment in mice. Pharmacol Res. Nov;173:105832. 2021. (doi: 10.1016/j.phrs.2021.105832.)
  5. Mizoguchi A,Banno R,Sun R,Yaginuma H,Taki K,Kobayashi T,Sugiyama M,Tsunekawa T,Onoue T,Takagi H,Hagiwara D,Ito Y,Iwama S,Suga H,Nagai T,Yamada K,Arima H. Glucocorticoid receptor signaling in ventral tegmental area neurons increases the rewarding value of a high-fat diet in mice. Sci Rep.Jun 18;11(1):12873. (Jun 18;11(1):12873.)
  6. Nakai T, Yamada K, Mizoguchi H. Alzheimer's Disease Animal Models: Elucidation of Biomarkers and Therapeutic Approaches for Cognitive Impairment. Int J Mol Sci. May 24;22(11):5549. 2021. (doi: 10.3390/ijms22115549.)
  7. Tsuneura Y, Sawahata M, Itoh N, Miyajima R, Mori D, Kohno T, Hattori M, Sobue A, Nagai T, Mizoguchi H, Nabeshima T, Ozaki N, Yamada K. Analysis of Reelin signaling and neurodevelopmental trajectory in primary cultured cortical neurons with RELN deletion identified in schizophrenia. Neurochem Int. Mar;144:104954. (doi: 10.1016/j.neuint.2020.104954.)
  8. Lin You-Hsin, Yamahashi Yukie, Kuroda Keisuke, Faruk Omar, Zhang Xinjian, Yamada Kiyofumi, Yamanaka Akihiro, Nagai Taku, Kaibuchi Kozo. Accumbal D2R-medium spiny neurons regulate aversive behaviors through PKA-Rap1 pathway. Neurochem Int. Feb;143:104935. (doi: 10.1016/j.neuint.2020.104935.)
  9. Hada Kazuhiro, Wulaer Bolati, Nagai Taku, Itoh Norimichi, Sawahata Masahito, Sobue Akira, Mizoguchi Hiroyuki, Mori Daisuke, Kushima Itaru, Nabeshima Toshitaka, Ozaki Norio, Yamada Kiyofumi.Mice carrying a schizophrenia-associated mutation of the Arhgap10 gene are vulnerable to the effects of methamphetamine treatment on cognitive function: association with morphological abnormalities in striatal neurons. Mol Brain.
    Jan 22;14(1):21. (doi: 10.1186/s13041-021-00735-4.)

2020年

  1. Wulaer Bolati, Hada Kazuhiro, Sobue Akira, Itoh Norimichi, Nabeshima Toshitaka, Nagai Taku, Yamada Kiyofumi.Overexpression of astroglial major histocompatibility complex class I in the medial prefrontal cortex impairs visual discrimination learning in mice. Mol Brain. Dec 14;13(1):170. 2020. (doi: 10.1186/s13041-020-00710-5.)
  2. Hase Tetsunari, Miyazaki Masayuki, Ichikawa Kazuya, Yogo Naoyuki, Ozawa Naoya, Hatta Takahiro, Ando Masahiko, Sato Mitsuo, Kondo Masashi, Yamada Kiyofumi, Hasegawa Yoshinori. Short hydration with 20 mEq of magnesium supplementation for lung cancer patients receiving cisplatin-based chemotherapy: a prospective study. Int J Clin Oncol. Nov;25(11):1928-1935. (doi: 10.1007/s10147-020-01755-1.)
  3. Ibi Daisuke, Nakasai Genki, Koide Nayu, Sawahata Masahito, Kohno Takao, Takaba Rika, Nagai Taku, Hattori Mitsuharu, Nabeshima Toshitaka, Yamada Kiyofumi, Hiramatsu Masayuki. Reelin Supplementation Into the Hippocampus Rescues Abnormal Behavior in a Mouse Model of Neurodevelopmental Disorders.Front Cell Neurosci . Sep 2;14:285.2020. (doi: 10.3389/fncel.2020.00285.)
  4. Ozawa Naoya, Hase Tetsunari, Hatta Takahiro, Sagara Atsunobu, Ichikawa Kazuya, Miyazaki Masayuki, Yogo Naoyuki, Ando Masahiko, Hashimoto Naozumi, Yamada Kiyofumi, Hasegawa Yoshinori. Comparing incidences of infusion site reactions between brand-name and generic vinorelbine in patients with non-small cell lung cancer. Br J Clin Pharmacol. Mar;87(3):1318-1326. (doi: 10.1111/bcp.14516.)
  5. Sato Yoshitaka, Iguchi Mitsutaka, Kato Yoshiaki, Morioka Hiroshi, Hirabayashi Aki, Tetsuka Nobuyuki, Tomita Yuka, Kato Daizo, Yamada Kiyofumi, Kimura Hiroshi, Yagi Tetsuya. Number of concomitant drugs with thrombocytopenic adverse effects and the extent inflammatory response resolution are risk factors for thrombocytopenia in patients treated with linezolid for more than 14 days. NAGOYA JOURNAL OF MEDICAL SCIENCE. 82(3): 407-414.2020. (10.18999/nagjms.82.3.407.)
  6. Sekiguchi Mariko, Sobue Akira, Kushima Itaru, Wang Chenyao, Arioka Yuko, Kato Hidekazu, Kodama Akiko, Kubo Hisako, Ito Norimichi, Sawahata Masahito, Hada Kazuhiro, Ikeda Ryosuke, Shinno Mio, Mizukoshi Chikara, Tsujimura Keita, Yoshimi Akira, Ishizuka Kanako, Takasaki Yuto, Kimura Hiroki, Xing Jingrui, Yu Yanjie, Yamamoto Maeri, Okada Takashi, Shishido Emiko, Inada Toshiya, Nakatochi Masahiro, Takano Tetsuya, Kuroda Keisuke, Amano Mutsuki, Aleksic Branko, Yamomoto Takashi, Sakuma Tetsushi, Aida Tomomi, Tanaka Kohichi, Hashimoto Ryota, Arai Makoto, Ikeda Masashi, Iwata Nakao, Shimamura Teppei, Nagai Taku, Nabeshima Toshitaka, Kaibuchi Kozo, Yamada Kiyofumi, Mori Daisuke, Ozaki Norio. ARHGAP10, which encodes Rho GTPase-activating protein 10, is a novel gene for schizophrenia risk. Transl Psychiat. Jul 22;10(1):247.(doi: 10.1038/s41398-020-00917-z.)
  7. Hori Kei, Yamashiro Kunihiko, Nagai Taku, Shan Wei, Egusa Saki F., Shimaoka Kazumi, Kuniishi Hiroshi, Sekiguchi Masayuki, Go Yasuhiro, Tatsumoto Shoji, Yamada Mitsuyo, Shiraishi Reika, Kanno Kouta, Miyashita Satoshi, Sakamoto Asami, Abe Manabu, Sakimura Kenji, Sone Masaki, Sohya Kazuhiro, Kunugi Hiroshi, Wada Keiji, Yamada Mitsuhiko, Yamada Kiyofumi, Hoshino Mikio. AUTS2 Regulation of Synapses for Proper Synaptic Inputs and Social Communication. iScience. Jun 26;23(6). 2020. (doi: 10.1016/j.isci.2020.101183.)
  8. Wulaer Bolati, Kunisawa Kazuo, Hada Kazuhiro, Suento Willy Jaya, Kubota Hisayoshi, Iida Tsubasa, Kosuge Aika, Nagai Taku, Yamada Kiyofumi, Nitta Atsumi, Yamamoto Yasuko, Saito Kuniaki, Mouri Akihiro, Nabeshima Toshitaka:  Shati/Nat8l deficiency disrupts adult neurogenesis and causes attentional impairment through dopaminergic neuronal dysfunction in the dentate gyrus. J Neurochem.May;157(3):642-655. 2021. (doi: 10.1111/jnc.15022.)
  9. Sawahata Masahito, Mori Daisuke, Arioka Yuko, Kubo Hisako, Kushima Itaru, Kitagawa Kanako, Sobue Akira, Shishido Emiko, Sekiguchi Mariko, Kodama Akiko, Ikeda Ryosuke, Aleksic Branko, Kimura Hiroki, Ishizuka Kanako, Nagai Taku, Kaibuchi Kozo, Nabeshima Toshitaka, Yamada Kiyofumi, Ozaki Norio: Generation and analysis of novel Reln-deleted mouse model corresponding to exonic Reln deletion in schizophrenia. Psychiatry Clin Neurosci. May;74(5):318-327. 2020. (doi: 10.1111/pcn.12993.)
  10. Saito R, Koebis M, Nagai T, Shimizu K, Liao J, Wulaer B, Sugaya Y, Nagahama K, Uesaka N, Kushima I, Mori D, Maruyama K, Nakao K, Kurihara H, Yamada K, Kano M, Fukada Y, Ozaki N, Aiba A: Comprehensive analysis of a novel mouse model of the 22q11.2 deletion syndrome: A model with the most common 3.0-Mb deletion at the human 22q11.2 locus. Transl Psychiat. Feb 5; 10(1): 35., 2020. (doi: 10.1038/s41398-020-0723-z.)

2019年

  1. Funahashi Y, Ariza A, Emi R, Xu Y, Shan W, Suzuki K, Kozawa S, Ahammad R, Wu M, Takano T, Yura Y, Kuroda K, Nagai T, Amano M, Yamada K, Kaibuchi K.: Phosphorylation of NPAS4 by MAPK regulates reward-related gene expression and behaviors. Cell Rep. 29(10), 3235, 2019.(doi: 10.1016/j.celrep.2019.10.116)
  2. Hasegawa S, Yoshimi A, Mouri A, Uchida Y, Hida H, Mishina M, Yamada K, Ozaki N, Nabeshima T, Noda Y.: Acute administration of ketamine attenuates the impairment of social behaviors induced by social defeat stress exposure as juveniles via activation of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors. Neuropharmacology. 148,107-116, 2019.(doi: 10.1016/j.neuropharm. 2018.12.020.)
  3. Kitagawa K, Nagai T, Yamada K.: Pharmacological and proteomic analyses of neonatal polyl: C-treated adult mice. Neurosci Res.147: 39-47, 2019.(doi: 10.1016/j.neures.)
  4. Nakamura Y, Nakatochi M, Kunimoto S, Okada T, Aleksic B, Toyama M, Shiino T, Morikawa M, Yamauchi A, Yoshimi A, Furukawa-Hibi Y, Nagai T, Ohara M, Kubota C, Yamada K, Ozaki N. Methylation analysis for postpartum depression: a case control study. BMC Psychiatry. 19(1): 190, 2019.(doi: 10.1186/s12888-019-2172-x.)
  5. Uchida M, Hida H, Mori K, Yoshimi A, Kitagaki S, Yamada K, Hiraoka Y, Aida T, Tanaka K, Ozaki N, Noda Y: Functional roles of the glial glutamate transporter (GLAST) in emotional and cognitive abnormalities of mice after repeated phencyclidine administration. Eur Neuropsychopharmacol. 29: 914-924, 2019.
  6. Shan W, Nagai T, Tanaka M, Itoh N, Furukawa-Hibi Y, Nabeshima T, Sokabe M, Yamada K: Neuronal PAS domain protein 4 (Npas4) controls neuronal homeostasis in pentylenetetrazole-induced epilepsy through the induction of Homer1a. J Neurochem. 145(1):19-33, 2018.(doi: 10.1111/jnc.14274)
  7. Yoshimi A, Yamada S, Kunimoto S, Aleksic B, Hirakawa A, Ohashi M, Matsumoto Y, Hada K, Itoh N, Arioka Y, Kimura H, Kushima I, Nakamura Y, Shiino T, Mori D, Tanaka S, Hamada S, Noda Y, Nagai T, Yamada K, Ozaki N: Proteomic analysis of lymphoblastoid cell lines from schizophrenic patients. Transl Psychiatry. 9(1): 126, 2019.(doi: 10.1038/s41398-019-0479-5)
  8. Zhang X, Nagai T, Ahammad RU, Kuroda K, Nakamuta S, Nakano T, Yukinawa N, Funahashi Y, Yamahashi Y, Amano M, Yoshimoto J, Yamada K, Kaibuchi K: Balance between dopamine and adenosine signals regulates the PKA/Rap1 pathway in striatal medium spiny neurons. Neurochem Int. 122: 8-18, 2019.(doi: 10.1016/j.neuint. 2018.10.008.)

2018年

  1. Hasegawa S, Miyake Y, Yoshimi A, Mouri A, Hida H, Yamada K, Ozaki N, Nabeshima T, Noda Y.: Dysfunction of Serotonergic and Dopaminergic Neuronal Systems in the Antidepressant-Resistant Impairment of Social Behaviors Induced by Social Defeat Stress Exposure as Juveniles. Int J Neuropsychopharmacology. 21(9): 837-846, 2018.( doi: 10.1093/ijnp/pyy038.)
  2. Mouri A, Ukai M, Uchida M, Hasegawa S, Taniguchi M, Ito T, Hida H, Yoshimi A, Yamada K, Kunimoto S, Ozaki N, Nabeshima T and Noda Y.: Juvenile social defeat stress exposure persistently impairs social behaviors and neurogenesis. Neuropharmacology. 133: 23-37, 2018.
  3. Mizoguchi H, Wang T, Kusaba M, Fukumoto K, Yamada K. Nicotine and varenicline ameliorate changes in reward-based choice strategy and altered decision-making in methamphetamine-treated rats. Behav Brain Res. Feb 1;359:935-941, 2019. (doi: 10.1016/j.bbr.2018.06.016.)
  4. Nguyen PT, Shin EJ, Dang DK, Tran HQ, Jang CG, Jeong JH, Lee YJ, Lee YS, Yamada K, Nabeshima T, Kim HC: Role of dopamine D1 receptor in 3-fluoromethamphetamine-induced neurotoxicity in mice. Neurochem Int. 113: 69-84, 2018.
  5. Tajima H, Izumi T, Miyachi S, Matsubara N, Ito M, Imai T, Nishihori M, Shintai K, Okamoto S, Arak Y, Kumakura Y, Furukawa-Hibi Y, Yamada K and Wakabayashi T: Association between CYP2C19 genotype and the additional effect of cilostazol to clopidogrel resistance in neuroendovascular therapy. Nagoya J Med Sci. 80: 207-215, 2018.
  6. Tran V, Shin E-J, Nguyen LTT, Lee Y, Kim DJ, Jeong JH, Jang CG, Nah SY, Toriumi K, Nabeshima T, Yamada K, Kim HC: Protein Kinase Cδ Gene Depletion Protects Against Methamphetamine-Induced Impairments in Recognition Memory and ERK1/2 Signaling via Upregulation of Glutathione Peroxidase-1 Gene. Mol Neurobiol. 55: 4136-4159, 2018.(doi: 10.1007/s12035-017-0638-8.)
  7. Saifullah MAB, Nagai T, Kuroda K, Wulaer B, Nabeshima T, Kaibuchi K, Yamada K.: Cell type-specific activation of mitogen-activated protein kinase in D1 receptor-expressing neurons of the nucleus accumbens potentiates stimulus-reward learning in mice. Sci Rep. 8: 14413, 2018.(doi: 10.1038/s41598-018-32840-1.)
  8. Sobue A, Itoh N, Nagai T, Shan W, Hada K, Nakajima A, Murakami Y, Mouri A, Yamamoto Y, Nabeshima T, Saito K, Yamada K: Astroglial major histocompatibility complex class I following immune activation leads to behavioral and neuropathological changes. Glia. 66(5): 1034-1052, 2018.(doi: 10.1002/glia.23299)
  9. Sobue A, Kushima I, Nagai T, Shan W, Kohno T, Aleksic B, Aoyama Y, Mori D, Arioka Y, Kawano N, Yamamoto M, Hattori M, Nabeshima T, Yamada K, Ozaki N.: Genetic and animal model analyses reveal the pathogenic role of a novel deletion of RELN in schizophrenia. Sci Rep. 8: 13046, 2018.(doi: 10.1038/s41598-018-31390-w)
  10. Wulaer B, Nagai T, Sobue A, Itoh N, Kuroda K, Kaibuchi K, Nabeshima T, Yamada K: Repetitive and compulsive-like behaviors lead to cognitive dysfunction in Disc1Δ2-3/Δ2-3 mice. Genes Brain Behav. 17(8), UNSP e12478,2018.(doi: 10.1111/gbb.12478.)
  11. Yamada S, Itoh N, Nagai N, Nakai T, Ibi D, Nakajima A, Nabeshima T, Yamada K.: Innate immune activation of astrocytes impairs neurodevelopment via upregulation of follistatin-like 1 and interferon-induced transmembrane protein 3. J Neuroimmunol. 15(1): 295, 2018.(doi: 10.1186/s12974-018-1332-0.)

2017年

  1. Itoh N, Nagai T, Watanabe T, Taki K, Nabeshima T, Kaibuchi K, Yamada K.: Valocin-containing protein (VCP) is a novel IQ motif-containing GTPase activating protein 1 (IQGAP1) interacting protein. Biochem. Biophy. Res. Commun. 493:1384-1389, 2017.
  2. Tran HQ, Chung YH, Shin EJ, Tran T-Y, Jeong JH, Jang CG, Nah SY, Yamada K, Nabeshima T, Kim HC: Mk-801, but not naloxone, atteneuates high-dose dextropethorpahn-induced convulsive behavior: Possble involvement of the GluN2B receptor. Tox. App. Pharmacol. 334:158-166, 2017.
  3. Tran V, Shin E-J, Nguyen LTT, Lee Y, Kim DJ, Jeong JH, Jang CG, Nah SY, Toriumi K, Nabeshima T, Yamada K, Kim HC: Protein Kinase Cδ Gene Depletion Protects Against Methamphetamine-Induced Impairments in Recognition Memory and ERK1/2 Signaling via Upregulation of Glutathione Peroxidase-1 Gene. Mol Neurobiol., doi:10.1007/s12035-017-0638-8, 2017.
  4. Mouri A, Noda Y, Niwa M, Matsumoto Y, Mamiya T, Nitta A, Yamada K, Furukawa S, Iwamura T, Nabeshima T: The involvement of brain-derived neurotrophic factor in 3,4-methylenedioxymethamphetamine-induced place preference and behavioral sensitization. Behav Brain Res., 329:157-165, 2017.
  5. Konishi H, Ohgami N, Matsushita A, Kondo Y, Aoyama Y, Kobayashi M, Nagai T, Ugawa S, Yamada K, Kato M, Kiyama H: Exposure to diphtheria toxin during the juvenile period impairs both inner and outer hair cells in C57BL/6 mice. Neuroscience 351:15-23, 2017.
  6. Kubo K, Deguchi K, Nagai T, Ito Y, Endo T, Benner S, Shan W, Kitazawa A, Aramaki M, Ishii K, Kakeyama M, Tohyama C, Tanaka K, Takashima S, Nakayama M, Itoh M, Antalffy M, Armstrong D D, Yamada K, Inoue K, Nakajima K: Association of impaired neuronal migration with cognitive deficits in extremely preterm infants. JCI Insight. 2017 May 18;2(10). pii: 88609. doi: 10.1172/jci.insight.88609.

2016年

  1. Tran V, Shin E-J, Jeong JH, Lee JW, Lee Y, Jang CG, Nah SY, Lei XG, Toriumi K, Yamada K, Nabeshima T, Kim HC. Protective potential of the glutathione peroxidase-1 gene in abnormal behaviors induced by phencyclidine in mice. Mol Neurobiol., DOI 10.1007/s12035-016-0239-y, 2016.
  2. Tran V, Shin EJ, Ko SK, Nam Y, Chung YH, Jeong JH, Jang CG, Nah SY, Yamada K, Nabeshima T, Byun JK, Kim HC: Mountain-cultivated ginseng attenuates phencyclidine-induced abnormal behaviors in mice by positive modulation of glutathione in the prefrontal cortex of mice. J. Med. Food, 19:1-9, 2016.
  3. Tran V, Chung YH, Shin E-J, Kim WK, Lee JC, Jeong JH, Wie MB, Jang CG, Yamada K, Nabeshima T, Kim HC. High-dose dextromethorphan produces myelinod bodies in the hippocampus of rats. J. Pharmacol. Sci. 132:166-170, 2016.
  4. Nagai T, Nakamuta S, Kuroda K, Nakauchi S, Nishioka T, Takano T, Zhang X, Tsuboi D, Funahashi Y, Nakano T, Yoshimoto J, Kobayashi K, Uchigashima M, Watanabe M, Miura M, Nishi A, Kobayashi K, Yamada K, Amano M, Kaibuchi K.: Phospho-proteomics of the dopamine pathway enables discovery of Rap1 activation as a reward signal in vivo. Neuron 89: 550-565, 2016.
  5. Aoyama Y, Toriumi K, Mouri A, Hattori T, Ueda E, Shimato A, Sakakibara N, Soh Y, Mamiya T, Nagai T, Kim HC, Hiramatsu M, Nabeshima T, Yamada K: Prenatal nicotine exposure impairs the proliferation of neuronal progenitors, leading to fewer glutamatergic neurons in the medial prefrontal cortex. Neuropsychopharmacology 41: 578-589, 2016.

2015年

  1. Sakaguchi H, MuramatsuH, Makishima H, Xu Y, Hibi Y, Wang X, Narita A, Okuno Y, Yoshida K, Shiraishi Y, Doisaki S, Yoshida N, Hama A, Takahashi Y, Yamada K, Miyano S, Ogawa S, Maciejewski JP, Kojima S.: Aberrant DNA methylation is associated with a poor outcome in juvenile myelomonocytic leukemia. PLOS ONE, 2015 Dec 31;10(12):e0145394. doi: 10.1371/journal.pone.0145394.
  2. Hori K, Nagai T, Shan W, Sakamoto A, Abe M, Yamazaki M, Sakimura K, Yamada K, Hoshino M: Heterozygous disruption of Autism susceptibility candidate 2 causes impaired emotional control and cognitive memory. PLOS ONE 10(12): e0145979.doi:10.1371/journal.pone.014579, 2015
  3. Mita T, Furukawa-Hibi Y, Takeuchi H, Hattori H, Yamada K, Hibi H, Ueda M, Yamamoto A: Conditioned medium from the stem cells of human dental pulp improves cognitive function in a mouse model of Alzheimer's disease. Behav Brain Res. 293:189-197, 2015.
  4. Furukawa-Hibi Y, Yun J, Nagai T, Yamada K: Stress increases DNA methylation of the neuronal PAS domain 4 (Npas4) gene. Neuroreport 26:827-832, 2015.
  5. Mizoguchi H, Katahira K, Inutsuka A, Fukumoto K, Wang T, Nagai T, Sato J, Sawada M, Ohira H, Yamanaka A, Yamada K: Insular neural system controls decision-making in healthy and methamphetamine-treated rats. Proc. Natl. Acad. Sci. USA., 112:E3930-3939, 2015.
  6. Udagawa T, Fujioka Y, Tanaka M, Honda D, Yokoi S, Riku Y, Ibi D, Nagai T, Yamada K, Watanabe H, Katsuno M, Inada T, Ohno K, Sokabe M, Okado H, Ishigaki S, Sobue G: FUS regulates AMPA receptor function and FTLD/ALS-associated behavior via GluA1 mRNA stabilization. Nat. Commun. 6:7098 doi: 10.1038/ncomms8098, 2015.
  7. Ishii K, Nagai T, Hirota Y, Noda M, Nabeshima T, Yamada K, Kubo K, Nakajima K.: Reelin has a preventive effect on phencyclidine-induced cognitive and sensory-motor gating deficits. Neurosci. Res. 96:30-36, 2015.
  8. Nakajima A, Aoyama Y, Shin, EJ, Nam Y, Kim HC, Nagai T, Yokosuka A, Mimaki Y, Yokoi, T, Ohizumi Y, Yamada K: Nobiletin, a citrus flavonoid, improves cognitive impairment and reduces soluble Ab levels in a triple transgenic mouse model of Alzheimer's disease (3XTg-AD). Behav. Brain Res. 289: 69-77, 2015.
  9. Hida H, Mouri A, Mori K, Matsumoto Y, Seki T, Taniguchi M, Yamada K, Iwamoto K, Ozaki N, Nabeshima T, Noda Y: The complex mechanism of blonanserin action involving D3-5-HT2A and D1-NMDA receptors in the mPFC. Neuropsychopharmacology 40:601-613, 2015.

2014年

  1. Toriumi K, Kondo M, Nagai T, Hashimoto R, Ohi K, Song Z, Tanaka J, Mouri A, Koseki T, Yamamori H, Furukawa-Hibi Y, Mamiya T, Fukushima T, Takeda M, Nitta A, Yamada K, and Nabeshima T.: Deletion of SHATI/NAT8L increases dopamine D1 receptor on the cell surface in the nucleus accumbens, accelerating methamphetamine dependence. Int. J. Neuropsychopharmacol. 17:443-453, 2014.
  2. Hida H, Mouri A, Ando Y, Mori K, Mamiya T, Iwamoto K, Ozaki N,Yamada K, Nabeshima T and Noda Y: Combination of neonatal Polyl:C and adolescent phencyclidine treatments is required to induce behavioral abnormalities with overexpression of GLAST in adult mice. Behav. Brain Res., 258:34-42, 2014.
  3. Aoyama Y, Mouri A, Toriumi K, Koseki T, Narusawa S, Ikawa N, Mamiya T, Nagai T, Yamada K and Nabeshima T: Clozapine ameliorates epigenetic and behavioral abnormalities induced by phencyclidine through activation of dopamine D1 receptor. Int. J. Neuropsychopharmacol. In press.
  4. Mano Y, Kotani T, Ito M, Nagai T, Ichinohashi Y, Yamada K, Ohno K, Kikkawa F and Toyokuni S: Maternal molecular hydrogen administration ameliorates rat fetal hippocampal damage by in utero ischemia-reperfusion. Free Radic. Biol. Med., in press.
  5. Yamada S, Nagai T, Nakai T, Ibi D, Nakajima A, and Yamada K: Matrix metalloproteinase-3 is a possible mediator of neurodevelopmental impairment due to polyI:C-induced innate immune activation of astrocytes. Brain Behav Immun., in press.
  6. Nakajima N, Ohizumi Y, Yamada K: Anti-dementia activity of nobiletin, a citrus flavonoid. Clin. Psychopharmacol. Neurosci., in press.
  7. Hori K, Nagai T, Shan W, Sakamoto A, Taya S, Hashimoto R, Hayashi T, Abe M, Yamazaki M, Nakao K, Nishioka T, Sakimura K, Yamada K, Kaibuchi K, Hoshino M.: Cytoskeletal Regulation by AUTS2 in Neuronal Migration and Neuritogenesis. Cell Rep. 9:2166-2179, 2014.
  8. Nakajima A, Ibi D, Nagai T, Yamada S, Nabeshima T, Yamada K: Induction of interferone-induced transmembrane protein 3 gene expression by lipopolysaccharide in astrocytes. Eur. J. Pharmacol., 745:166-175, 2014.
  9. Nakai T, Nagai T, Tanaka M, Itoh N, Asai N, Enomoto A, Asai M, Yamada S, Saifullah MAB, Sokabe M, Takahashi M, Yamada K: Girdin phosphorylation is crucial for synaptic plasticity and memory: a potential role in the interaction of BDNF/TrkB/Akt signaling with NMDA receptor. J. Neurosci., 34:14995-15008, 2014.
  10. Maeda O, Ando T, Ohmiya N, Ishiguro K, Watanabe O, Miyahara R, Hibi Y, Nagai T, Yamada Yoshihara S, Takahashi H, Nishimura N, Kinoshita M, Asahina R, Kitsuki M, Tatsumi K, Hibi Y, Hirai H, Nagai T, Yamada K, Tsuboi A: Npas4 regulates the expression of Mdm2 that ubiquitinates Dcx to remodel dendritic spines in olfactory bulb interneurons after sensory experience. Cell Rep, 8:1-15, 2014.
  11. Nakai T, Nagai T, Wang R, Yamada S, Kuroda K, Kaibuchi K, Yamada K: Alterations of GABAergic and dopaminergic system in mutant mice with disruption of exons 2 and 3 of the Disc1 gene. Neurochem. Int., 74:74-83, 2014.
  12. Yamada S, Nagai T, Nakai T, Ibi D, Nakajima A, and Yamada K: Matrix metalloproteinase-3 is a possible mediator of neurodevelopmental impairment due to polyI:C-induced innate immune activation of astrocytes. Brain Behav Immun., 38:272-282, 2014.
  13. Aoyama Y, Mouri A, Toriumi K, Koseki T, Narusawa S, Ikawa N, Mamiya T, Nagai T, Yamada K, Nabeshima T: Clozapine ameliorates epigenetic and behavioral abnormalities induced by phencyclidine through activation of dopamine D1 receptor. Int. J. Neuropsychopharmacol., 17:723-737, 2014.
  14. Hida H, Mouri A, Ando Y, Mori K, Mamiya T, Iwamoto K, Ozaki N, Yamada K, Nabeshima T, Noda Y: Combination of neonatal Polyl:C and adolescent phencyclidine treatments is required to induce behavioral abnormalities with overexpression of GLAST in adult mice. Behav. Brain Res., 258:34-42, 2014.
  15. Toriumi K, Kondo M, Nagai T, Hashimoto R, Ohi K, Song Z, Tanaka J, Mouri A, Koseki T, Yamamori H, Furukawa-Hibi Y, Mamiya T, Fukushima T, Takeda M, Nitta A, Yamada K, Nabeshima T.: Deletion of SHATI/NAT8L increases dopamine D1 receptor on the cell surface in the nucleus accumbens, accelerating methamphetamine dependence. Int. J. Neuropsychopharmacol., 17:443-453, 2014.

2013年

  1. Mouri A, Nagai T, Ibi D and Yamada K: Animal models of schizophrenia for molecular and pharmacological intervention and potential candidate molecules. Neurobiol. Dis., 53:61-74, 2013.
  2. Mizoguchi H and Yamada K: Roles of matrix metalloproteinases and their targets in epileptogenesis and seizures. Clin. Psychopharmacol. Neurosci., 11:45-52, 2013
  3. Miyazaki M, Noda Y, Mouri A, Kobayashi K, Mishina M, Nabeshima N, Yamada K: Role of convergent activation of glutamatergic and dopaminergic systems in the nucleus accumbens in the development of methamphetamine psychosis and dependence. Int. J. Neuropsychopharmacol., 16(6):1341-50, 2013.
  4. Yun J, Nagai T, Furukawa-Hibi Y, Kuroda K, Kaibuchi K and Yamada K: Neuronal Per Arnt Sim (PAS) domain protein 4 (Npas4) regulates neurite outgrowth and phosphorylation of synapsin I. J. Biol. Chem., 288: 2655-2664, 2013.
  5. Ibi D, Nagai T, Nakajima A, Mizoguchi H, Kawase T, Tsuboi D, Kano S, Sato Y, Hayakawa M, Lange UC, Adams DJ, Surani MA, Satoh T, Sawa A, Kaibuchi K, Nabeshima T and Yamada K: Astroglial IFITM3 mediates neuronal impairments following neonatal immune challenge in mice. Glia 61: 679-693, 2013.
  6. Alkam,T, Kim HC, Hiramatsu M, Mamiya T, Aoyama Y, Nitta A, Yamada K and Nabeshima T: Evaluation of emotional behaviors in young offspring of C57BL/6J mice after gestational and/or perinatal exposure to nicotine in six different time-windows. Behav. Brain Res., 239:80-89, 2013.
  7. Zhang L, Nagai T, Yamada K, Ibi D, Ichihara S, Suburamanian K, HuangZ, Mohideen SS, Naito H and Ichihara G.: Effects of sub-acute and sub-chronic inhalation of 1-bromopropane on neurogenesis in adult rats. Toxicology, 304:76-82, 2013.
  8. Yan Y, Miyamoto Y, Nitta A, Muramatsu S, Ozawa K, Yamada K and Nabeshima T: Intrastriatal gene delivery of GDNF persistently attenuates methamphetamine self-administration and relapse in mice. Int. J. Neuropsychopharmacol., 16:1559-1567, 2013.
  9. Nakajima A, Aoyama Y, Nguyen TTL, Shin EJ, Kim HC, Yamada S, Nakai T, Nagai T, Yokosuka A, Mimaki Y, Ohizumi Y and Yamada K: Nobiletin, a citrus flavonoid, ameliorates cognitive impairment, oxidative burden, and hyperphosphorylation of tau in senescence-accelerated mouse. Behav. Rain Res., 250:351-360, 2013.
  10. Alkam T, Kim HC, Mamiya T, Yamada K, Hiramatsu M and Nabeshima T: Evaluation of cognitive behaviors in young offspring of C57BL/6J mice after gestational nicotine exposure during different time-windows. Psychopharmacology, 230:451-463, 2013.
  11. Toriumi K, Miki I, Kondo M, Mouri A, Koseki T, Ibi D, Hurukawa-Hibi Y, Nagai T, Mamiya T, Nitta A, Yamada K and Nabeshima T: SHATI/NAT8L regulates neurite outgrowth via microtubule stabilization. J. Neurosci. Res., 91:1525-1532, 2013.

2012年

  1. Tran HY, Shin EJ, Saito K, Nguyen XK, Chung YH, Jeong JH, Bach JH, Park DH, Yamada K, Nabeshima T, Yoneda Y, Kim HC.: Protective potential of IL-6 against trimethyltin-induced neurotoxicity in vivo. Free Radic.Biol. Med., 52:1159-1174, 2012.
  2. Takuma K, Mizoguchi H, Funatsu Y, Hoshina Y, Himeno Y, Fukuzaki E, Kitahara Y, Arai S, Ibi D, Kamei H, Matsuda T, Koike K, Inoue M, Nagai T and Yamada K: Combination of chronic stress and ovariectomy causes conditioned fear memory deficits and hippocampal cholinergic neuronal loss in mice. Neuroscience, 207:261-273, 2012.
  3. Mouri A, Sasaki A, Watanabe K, Sogawa C, Kitayama S, Mamiya M, Miyamoto Y, Yamada K, Noda Y and Nabeshima T: MAGE-D1 regulates expression of depression-like behavior through serotonin transporter ubiquitylation. J. Neurosci., 28:4562-4580, 2012.
  4. Yan Y, Nitta A, Koseki T, Yamada K, Nabeshima T: Dissociable role of tumor necrosis factor alpha gene deletion in methamphetamine self-administration and cue-induced relapsing behavior in mice. Psyhopharmacology 221: 427-436, 2012.
  5. Jin D, Muramatsu S, Shimizu N, Yokoyama S, Hirai K, Yamada K, Liu H-X, Higashida C, Hashii M, Higashida A, Asano M, Ohkuma S and Higashida H: Dopamine release via the vacuolar ATPase V0 sector c-subunit, confirmed in N18 neuroblastoma cells, results in behavioral recovery in hemiparkinsonian mice. Neurochem. Int., 61:907-912, 2012.
  6. Nakamoto K, Kawasaki S, Kobori T, Fujita-Hamabe W, Mizoguchi H, Yamada K, Nabeshima T, Tokuyama S: Involvement of matrix metalloproteinase-9 in the development of morphine tolerance. Eur. J. Pharmacol., 683:86-92, 2012.
  7. Nakajima A, Kinugasa Y, Torii J, Hishinuma T, Tomioka Y, Yamada K , Yamakuni T: Repeated treatment with nicotine induces phosphorylation of NMDA receptor NR2B subunit in the brain regions involved in behavioral sensitization. Neurosci. Lett., 524:133-138, 2012.
  8. Takuma K, Mizoguchi H,Funatsu Y, Kitahara Y, Ibi D, Kamei H, Matsuda T, KoikeK, Inoue M, Nagai T, Yamada K: Placental extract improves hippocampal neuronal loss and fear memory impairment resulting from chronic restraint stress in ovariectomized mice. J. Pharmacol. Sci., 120:89-97, 2012.
  9. Furukawa-Hibi Y, Nitta A, Fukumitsu H, Somiya H, Toriumi K, Furukawa S, Nabeshima T and Yamada K: Absence of SHATI/Nat81 reduces social interaction in mice. Neurosci. Lett., 526:79-84, 2012.
  10. Nagai T, Yu J, Kitahara Y, Nabeshima T and Yamada K: D-serine ameliorates neonatal polyI:C treatment-induced emotional and cognitive impairments in adult mice. J. Pharmacol. Sci., 120:213-227, 2012.
  11. Furukawa-Hibi Y, Yun J, Nagai T and Yamada K.: Transcriptional suppression of the neuronal PAS domain 4 (Npas4) gene by stress via the binding of agonist-bound glucocorticoid receptor to its promoter. J. Neurochem., 123:866-875, 2012.

2011年

  1. Mizoguchi H, Ibi D, Takase F, Nagai T, Kamei H, Toth E, Sato J, Takuma K and Yamada K: Nicotine ameliorates impairment of working memory in methamphetamine-treated rats. Behav. Brain Res. 220:159-163, 2011.
  2. Alkam T, Hiramatsu M, Mamiya T, Aoyama Y, Nitta A, Yamada K, Kim HC and Nabeshima T: Evaluation of object-based attention in mice. Behav. Brain Res. 220:185-193, 2011.
  3. Shin EJ, Kim JM, Nguyen XKT, Nguyen TTL, Lee SY, Jung JH, Kim MJ, Whang WK, Yamada K, Nabeshima T and Kim HC: Effect of Gastrodia Elata Bl on phencyclidine-induced schizophrenia-like psychosis in mice. Curr. Neuropharmacol. 9:247-250, 2011.
  4. Wakasaya Y, Kawarabayashi T, Watanabe M, Yamamoto-Watanabe Y, Takamura A, Kurata T, Murakami T, Abe K, Yamada K, Wakabayashi K, Sasaki A, Westaway D, Hyslop PG, Matsubara E, Shoji M: Factors responsible for neurofibrillary tangles and neuronal cell losses in tauopathy. J. Neurosci. Res. 89:576-584, 2011.
  5. Furukawa-Hibi Y, Nitta A, Ikeda T, Morishita K, Liu W, Ibi D, Alkam T, Nabeshima T and Yamada K: The hydrophobic dipeptide Leu-Ile inhibits immobility induced by repeated forced swimming via the induction of BDNF. Behav Brain Res., 220: 271-280, 2011.
  6. Shichi K, Fujita-Hamabe W, Harada S, Mizoguchi H, Yamada K, Nabeshima T and Tokuyama S: Involvement of matrix metalloproteinase-mediated proteolysis of neuronal cell adhesion molecule in the development of cerebral ischemic neuronal damage. J. Pharmacol. Exp. Ther., 338:701-710, 2011.
  7. Furukawa-Hibi Y, Alkam T, Nitta A, Matsuyama A, Mizoguchi H, Suzuki K, Moussaoui S, Yu Q-S, Greig NH, Nagai T and Yamada K: Butyrylcholinesterase inhibitors ameliorate cognitive dysfunction induced by amyloid-s peptide in mice. Behav Brain Res., 225:222-229, 2011.
  8. Nagai T, Kitahara Y, Ibi D, Nabeshima T, Sawa A and Yamada K: Effects of antipsychotics on the behavioral deficits in human dominant-negative DISC1 transgenic mice with neonatal polyI:C treatment. Behav. Brain Res., 225:305-310, 2011.
  9. Mizoguchi H, Nakade J, Tachibana M, Ibi D, Someya E, Koike H, Kamei H, Nabeshima T, Itohara S, Takuma K, Sawada M, Sato J and Yamada K: Matrix metalloproteinase-9 contributes to kindlined seizure development in pentylenetetrazole-treated mice by converting pro-BDNF to mature BDNF in the hippocampus. J Neurosci., 31:12963-12971, 2011.
  10. Kuroda K, Yamada S, Tanaka, Iizuka M, Yano H, Mori D, Tsuboi D, Nishioka T, Namba T, Iizuka Y, Kubota S, Nagai T, Ibi D, Wang R, Enomoto A, Isotani-Sakakibara M, Asai N, Kimura K, Kiyonari H, Abe T, Mizoguchi A, Sokabe M, Takahashi M, Yamada K and Kaibuchi K: Behavioral alterations associated with targeted disruption of exons 2 and 3 of the DISC1 gene in the mouse. Hum. Mol. Genet., 20, 4666-4683, 2011.
  11. Mizoguchi H. and Yamada K: Pharmacologic treatment with GABAB receptor agonist on methamphetamine-induced cognitive impairment in mice. Curr. Neuropharmacol., 9, 109-112, 2011.
  12. Yamada K: Translational research in neurodevelopmental disorders: Development of etiology-based animal models (Foreword). Biol. Pharm. Bull. 34, 1357, 2011.
  13. Nagai T, Ibi D and Yamada K: Animal model for schizophrenia that reflects gene-environment interactions. Biol. Pharm. Bull. 34, 1364-1368, 2011.
  14. Mizoguchi H, Yamada K and Nabeshima T: Matrix metalloproteinases contribute to neuronal dysfunction in animal models of drug dependence, Alzheimer's disease, and epilepsy. Biochem. Res. Int., 2011.

2010年

  1. Ibi D, Nagai T, Koike H, Kitahara Y, Mizoguchi H, Niwa M, Jaaro-Peled H, Nitta A, Yoneda Y, Nabeshima T, Sawa A, and Yamada K: Combined effect of neonatal immune activation and mutant DISC1 on phenotypic changes in adulthood. Behav. Brain Res., 206, 32-37, 2010.
  2. Nagai T, Kitahara Y, Shiraki A, Hikita T, Taya S, Kaibuchi K and Yamada K: Dysfunction of dopamine release in the prefrontal cortex of dysbindin deficient sandy mice: an in vivo microdialysis study. Neurosci. Lett., 470:134-138, 2010.
  3. Lu P, Mamiya T, Lu L, Mouri A, Niwa M, Kim HC, Zou LB, Nagai T, Yamada K, Ikejima T, Nabeshima T.: Silibinin attenuates cognitive deficits and decreases of dopamine and serotonin induced by repeated methamphetamine treatment. Behav Brain Res., 207:387-393, 2010.
  4. Ohki M, Ohki Y, Ishihara M, Nishida C, Tashiro Y, Akiyama H, Komiyama H, Lund LR, Nitta A, Yamada K, Zhu Z, Ogawa H, Yagita H, Okumura K, Nakauchi H, Werb Z, Heissig B, and Hattori K: Tissue type plasminogen activator regulates myeloid-cell dependent neoangiogenesis during tissue regeneration. Blood, 115:4302-4312, 2010.
  5. Katsuno M, Adachi H, Minamiyama M, Waza M, Tokui K, Doi H, Mizoguchi H, Nitta A, Yamada K, Banno H, Suzuki K, Tanaka F, and Sobue G: Disrupted TGF-beta signaling in spinal and bulbar muscular atrophy. J. Neurosci., 30:5702-5712, 2010.
  6. Alkam T, Nitta A, Furukawa-Hibi Y, Niwa M, Mizoguchi H, Yamada K, and Nabeshima T.: Oral supplementation with Leu-Ile, a hydrophobic dipeptide, prevents the impairment of memory induced by amyloid beta in mice via restraining the hyperphosphorylation of extracellular signal-regulated kinase. Behav Brain Res., 210:184-90, 2010.
  7. Yu J, Nagai T, Ibi D, Kitahara Y, Nabeshima T and Yamada K.: Nicotine ameliorates emotional and cognitive impairments induced by neonatal polyI:C treatment in mice. The Open Behavioral Science Journal., 4: 9-18, 2010.
  8. Mizoguchi H, Ibi D, Takuma K, Toth E, Sato J, Itohara S, Nabeshima N and Yamada K.: Alterations of emotional and cognitive behaviors in matrix metalloproteinase-2 and -9-deficient mice. The Open Behavioral Science Journal., 4: 19-25, 2010.
  9. Yun J, Koike H, Ibi D, Toth E, Mizoguchi H, Nitta A, Yoneyama M, Ogita K, Yoneda Y, Nabeshima T, Nagai T and Yamada K: Chronic restraint stress impairs neurogenesis and hippocampus-dependent fear memory in mice: a possible involvement of a brain specific transcription factor Npas4. J. Neurochem, 114:1840-1851, 2010.
  10. Shin EJ, Whang WK, Kim S, Bach JH, Kim JM, Nguyen XKT, Nguyen TTL, Jung BD, Yamada K, Nabeshima T and and Kim HC: Parshin C attenuate phencyclidine-induced schizophrenia-like psychosis in mice: involvement of 5-HT1A receptor. J. Pharmacol. Sci. 113:404-408, 2010.
  11. Furukawa-Hibi Y, Nitta A, Fukumitsu H, Somiya H, Furukawa S, Nabeshima T and Yamada K: Overexpression of piccolo C2A domain induces depression-like behavior in mice. Neuroreport 21:1177-1181, 2010.
  12. Noda Y, Mouri A, Ando Y, Waki Y, Yamada SN, Yoshimi A, Yamada K, Ozaki N, Wang D, Nabeshima T.: Galantamine ameliorates the impairment of recognition memory in mice repeatedly treated with methamphetamine: involvement of allosteric potentiation of nicotinic acetylcholine receptors and dopaminergic-ERK1/2 systems. Int J Neuropsychopharmacol. 13: 1343-1354, 2010.

2009年

  1. Arai S, Takuma K, Mizoguchi H, Ibi D, Nagai T, Kamei H, Kim H.C. and Yamada K: GABAB receptor agonist baclofen improve methamphetamine-induced cognitive deficit in mice. Eur. J. Pharmacol. 602, 101-104, 2009.
  2. Villard V, Espallergues J, Keller E, Alkam T, Nitta A, Yamada K, Nabeshima, T, Vamvakides A and Maurice T: Anti-amnesic and neuroprotective effects of the aminotetrahydrofuran derivative ANAVEX1-41 against amyloid β25-35 -induced toxicity in mice. Neuropsychopharmacology,34, 1552-1566, 2009.
  3. Shin EJ, Chae JS, Park SJ, Kim SC, Koo KH, Yamada K, Nabeshima T and Kim HC: Growth hormone-releaser attenuates β-amyloid (1-42)-induced cognitive impairment via stimulation of the insulin-like growth factor (IGF) -1 receptor in mice. J. Pharmacol. Sci. 109, 139-143, 2009.
  4. Gu B, Nakamichi N, Zhang WS, Nakamura Y, Kambe Y, Fukumori R, Takuma K, Yamada K, Takarada T, Taniura H, Yoneda Y: Possible protection by notoginsenoside R1 against glutamate neurotoxicity mediated by N-methyl-D-aspartate receptors composed of an NR1/NR2B subunit assembly. J. Neurosci. Res., 87, 2145-2156, 2009.
  5. Koike H, Ibi D, Mizoguchi H, Nagai T, Nitta A, Takuma K, Nabeshima T, Yoneda Y and Yamada K: Behavioral abnormality and pharmacologic response in social isolation-reared mice. Behav. Brain Res., 202, 114-121, 2009.
  6. Ibi D, Nagai T, Kitahara Y, Mizoguchi H, Koike H, Shiraki A, Takuma K, Kamei H, Noda N, Nitta A, Nabeshima T, Yoneda Y and Yamada K: Neonatal polyI:C treatment in mice results in schizophrenia-like behavioral and neurochemical abnormalities in adulthood. Neurosci. Res., 64, 297-305, 2009.
  7. Kimura H, Yukitake H, Suzuki H, Tajima Y, Koyo Gomaibashi K, Morimoto S, Funabashi Y, Yamada K and Takizawa M.: A Chondroprotective Agent ITZ-1 Inhibits IL-1β-Induced MMP-13 Production and Suppresses NO-Induced Chondrocyte Death. J. Pharmacol. Sci., 110, 201-211, 2009.
  8. Shin EJ, Bing G, Chae JS, Kim TW, Bach JH, Park DH, Yamada K, Nabeshima T and Kim HC: Role of microsomal epoxide hydrolase in the methamphetamine-induced drug dependence in mice. J. Neurosci. Res., 87, 3679-3686, 2009.
  9. Jin CH, Shin EJ, Park JB, Jang CG, Li Z, Kim MS, Koo KH, Yoon HJ, Park SJ, Choi WC, Yamada K, Nabeshima T and Kim HC: Fustin flavonoid attenuates β-amyloid (1-42)-induced learning impairment. J. Neurosci. Res., 87, 3658-3670, 2009.
  10. Shin EJ, Jang CG, Bing G, Park DH, Oh CH, Koo KH, Oh KW, Yamada K, Nabeshima T and Kim HC: Prodynorphin gene deficiency potentiates nalbuphine-induced behavioral sensitization and withdrawal syndrome in mice. Drug Alcohol Dependence, 104, 175-184, 2009.
  11. Mizoguchi H, Takuma K, Fukuzaki E, Ibi D, Someya E, Akazawa K, Alkam T, Tsunekawa H, Mouri A, Noda Y, Nabeshima T and Yamada K: Matrix metalloprotease-9 inhibition improves amyloid β-mediated cognitive impairment and neurotoxicity in mice. J. Pharmacol. Exp. Ther., 331, 14-22, 2009.
  12. Otsuka N, Tsuritani K, Sakurai T, Kato K, Matoba R, Itoh J, Okuyama S, Yamada K and Yoneda Y. Transcriptional induction and translational inhibition of Arc and Cugbp2 in mice hippocampus after transient global ischemia under normothermic condition. Brain Res., 1287, 136-145, 2009.
  13. Mizoguchi H, Arai S, Koike H, Ibi D, Kamei H, Nabeshima T, Kim HC, Takuma K and Yamada K: Therapeutic potential of nicotine for methamphetamine-induced impairment of sensorimotor gating: involvement of pallidotegmental neurons. Psychopharmacology, 207:235-243, 2009.
  14. Takuma K, Fang F, Zhang W, Yan S, Fukuzaki E, Du H, Sosunov A, McKann G, Funatsu Y, Nakamichi N, Nagai T, Mizoguchi H, Ibi D, Hori O, Ogawa S, Stern DM, Yamada K and Yan SD: RAGE-mdiated signaling contributes to intraneuronal transport of amyloid-β and neuronal dysfunction. Proc Natl Acad Sci USA, 106, 20021-20026, 2009.

2008年

  1. Mizoguchi H, Takuma K, Fukakusa A, Ito Y, Nakatani A, Ibi D, Kim HC and Yamada K: Improvement by minocycline of methamphetamine-induced impairment of recognition memory in mice. Psychopharmacology (Berl) 196, 233-241, 2008.
  2. Fukakusa A, Nagai T, Mizoguchi H, Otsuka N, Kimura H, Kamei H, Kim H-C, Nabeshima T, Takuma K and Yamada K: Role of tissue plasminogen activator in the sensitization of methamphetamine-induced dopamine release in the nucleus accumbens. J. Neurochem. 105, 436-444, 2008.
  3. Ibi D, Takuma K, Koike H, Mizoguchi H, Tsuritani K, Kuwahara Y, Kamei H, Nagai T, Yoneda Y, Nabeshima T and Yamada K: Social isolation rearing-induced impairment of the hippocampal neurogenesis is associated with deficits in spatial memory and emotion-related behaviors in juvenile mice. J. Neurochem. 105, 921-932, 2008.
  4. Fukakusa A, Mizoguchi H, Koike H, Nabeshima T, Takuma K and Yamada K: Tissue plasminogen activator is not involved in methamphetamine-induced neurotoxicity. J. Pharmacol. Sci. 106, 321-324, 2008.
  5. Fukuzaki E, Takuma K, Himeno Y, Yoshida S, Funatsu Y, Kitahara Y, Mizoguchi H, Ibi D, Koike K, Inoue M and Yamada K: Enhanced activity of hippocampal BACE1 in a mouse model of postmenopausal memory deficits. Neurosci.Lett. 433, 141-145, 2008.
  6. Alkam T, Nitta A, Mizoguchi H, Saito K, Seshima M, Itoh A, Yamada K and Nabeshima T: Restraining tumor necrosis factor-alpha by thalidomide prevents the Abeta-induced impairment of recognition memory in mice. Behav. Brain Res. 189, 100-106, 2008.
  7. Tamaki K, Yamada K, Nakamichi N, Taniura H and Yoneda Y: Transient suppression of progenitor cell proliferation through NMDA receptors in hippocampal dentate gyrus of mice with traumatic stress experience. J. Neurochem. 105, 1642-1655, 2008.
  8. Kawanokuchi J, Shimizu K, Nitta A, Yamada K, Mizuno T, Takeuchi H and Suzumura A: Production and functions of IL-17 in microglia. J. Neuroimmunol. 194, 54-61, 2008.
  9. Fukuzaki E, Takuma K, Funatsu Y, Himeno Y, Kitahara Y, Gu B, Mizoguchi H, Ibi D, Koike K, Inoue M, Yan SD and Yamada K: Ovariectomy increases neuronal amyloid ? binding alchohol dehydrogenease level in the mouse hippocampus. Neurochem. Int. 52, 1358-1364, 2008.
  10. Alkam T, Nitta A, Mizoguchi H, Itoh A, Murai R, Nagai T, Yamada K and Nabeshima T: The extensive nitration of neurofilament light chain in the hippocampus is associated with the cognitive impairment induced by amyloid β in mice. J. Pharmacol. Exp. Ther. 327, 137-147, 2008.
  11. Yano K, Yamamura K, Osada T, Fukase F, Kiriyama N, Torimoto M, Yamada K, Kishi DT and Nabeshima T: Documenting the value of a pharmacist-managed anticoagulation classroom. J. Appl. Ther. Res. 6, 41-48, 2008.
  12. Arai S, Takuma K, Mizoguchi H, Ibi D, Nagai T, Takahashi K, Kamei H, Nabeshima T and Yamada K: Involvement of pallidotegmental neurons in methamphetamine- and MK-801-induced impairment of prepulse inhibition of the acoustic startle reflex in mice: reversal by GABAB receptor agonist baclofen. Neuropsychopharmacology 33, 3164-3175, 2008.
  13. Niwa M, Nitta A, Cen X, Kitaichi K, Ozaki N, Yamada K and Nabeshima T: A novel molecule 'shati' increases dopamine uptake via the induction of tumor necrosis factor-α| in pheochromocytoma-12 cells. J. Neurochem. 107, 1697-1708, 2008.
  14. Kanazawa Y, Makino M, Morishima Y, Yamada K, Nabeshima T, Shirasaki Y: Degradation of PEP-19, a calmodulin-binding protein, by calpain is implicated in neuronal cell death induced by intracellular Ca2+ overload. Neuroscience 154, 473-81, 2008.
  15. Yamada K and Kaneko S: Neuropsychotoxicity of abused drugs: Clinical and basic research and drug development: Preface [review]. J. Pharmacol. Sci. 106, 1, 2008.
  16. Mizoguchi H, Yamada K and Nabeshima T: Neuropsychotoxicity of Abused Drugs: Involvement of matrix metalloproteinase-2 and -9, and tissue inhibitor of matrix metalloproteinase-2 in methamphetamine-induced behavioral sensitization and reward in rodents [review]. J. Pharmacol. Sci. 106, 9-14, 2008.
  17. Yamada K: Role for anti-addictive and pro-addictive factor in drug dependence [review]. Nagoya J. Med. Sci. 70, 67-72, 2008.
  18. Yamada K: Endogenous modulators for drug dependence [review]. Biol. Pharm. Bull. 31, 1635-1638, 2008.
  19. Nagai T, Nabeshima T and Yamada K: Basic and translational research on proteinase-activated receptors: Regulation of nicotine reward by the tissue plasminogen activator (tPA)-plasmin system via proteinase-activated receptor 1 [review]. J. Pharmacol. Sci. 108, 4048-414, 2008.

2007年

  1. Ito Y, Takuma K, Mizoguchi H, Nagai T and Yamada K: A novel azaindolizinone derivative ZSET1446 (spiro[imidazo[1,2-a]pyridine-3,2-indan]-2(3H)-one) improves methamphetamine-induced impairment of recognition memory in mice by activating extracellular signal-regulated kinase 1/2. J. Pharmacol. Exp. Ther. 320, 819-827, 2007.
  2. Mizoguchi H, Yamada K, Niwa M, Mouri A, Mizuno T, Noda Y, Nitta A, Itohara S, Banno Y and Nabeshima T: Reduction of methamphetamine-induced sensitization and reward in matrix metalloproteinase-2 and -9 deficient mice. J. Neurochem. 100, 1579-1588, 2007.
  3. Takahashi K, Nagai T, Kamei H, Maeda K, Matsuya T, Arai S, Mizoguchi H, Yoneda Y, Nabeshima T, Takuma K and Yamada K: Neural circuits containing pallidotegmental GABAergic neurons are involved in the prepulse inhibition of the startle reflex in mice. Biol. Psychiatry 62, 148-157, 2007.
  4. Jin D, Liu HX, Hirai H, Torashima T, Nagai T, Lopatina O, Shnayder NA, Yamada K, Noda M, Seike T, Fujita K, Takasawa S, Yokoyama S, Koizumi K, Shiraishi Y, Tanaka S, Hashii M, Yoshihara T, Higashida K, Islam MS, Yamada N, Hayashi K, Noguchi N, Kato I, Okamoto H, Matsushima A, Salmina A, Munesue T, Shimizu N, Mochida S, Asano M and Higashida H: CD38 is critical for social behaviour by regulating oxytocin secretion. Nature 446, 41-45, 2007.
  5. Yan Y, Yamada K, Nitta A and Nabeshima T: Transient drug-primed but persistent cue-induced reinstatement of extinguished methamphetamine-seeking behavior in mice. Behav. Brain Res. 177, 261-268, 2007.
  6. Ito M, Nagai T, Mizoguchi H, Fukakusa A, Nakanishi Y, Kamei H, Nabeshima T, Takuma K and Yamada K: Possible involvement of protease-activated receptor-1 in the regulation of morphine-induced dopamine release and hyperlocomotion by the tissue plasminogen activator-plasmin system. J. Neurochem. 101, 1392-1399, 2007.
  7. Nagai T, Takuma K, Kamei H, Ito Y, Nakamichi N, Ibi D, Nakanishi Y, Murai M, Mizoguchi H, Nabeshima T and Yamada K: Dopamine D1 receptors regulate protein synthesis-dependent long-term recognition memory via extracellular signal-regulated kinase 1/2 in the prefrontal cortex. Learn Mem. 14, 117-125, 2007.
  8. Takuma K, Matsuo A, Himeno Y, Hoshina Y, Ohno Y, Funatsu Y, Arai S, Kamei H, Mizoguchi H, Nagai T, Koike K, Inoue M and Yamada K: 17β-Estradiol attenuates hippocampal neuronal loss and cognitive dysfunction induced by chronic restraint stress in ovariectomized rats. Neuroscience 146, 60-68, 2007.
  9. Yan Y, Yamada K, Mizoguchi H, Noda Y, Nagai T, Nitta A and Nabeshima T: Reinforcing effects of morphine are reduced in tissue plasminogen activator (tPA)-knockout mice. Neuroscience 146, 50-59, 2007.
  10. Maeda K, Sugino H, Hirose T, Kitagawa H, Nagai T, Mizoguchi H, Takuma K and Yamada K: Clozapine prevents a decrease in neurogenesis in mice repeatedly treated with phencyclidine. J. Pharmacol. Sci. 103, 299-308, 2007.
  11. Matsuya T, Takuma K, Sato K, Asai M, Murakami Y, Miyoshi S, Noda A, Nagai T, Mizoguchi H, Nishimura S and Yamada K: Synergistic effects of adenosine A2A antagonist and L-DOPA on rotational behaviors in 6-Hydroxydopamine-induced hemi-Parkinsonian mouse model. J. Pharmacol. Sci. 103, 329-332, 2007.
  12. Yan Y, Yamada K, Niwa M, Nagai T, Nitta A and Nabeshima T: Enduring vulnerability to reinstatement of methamphetamine-seeking behavior in glial cell line-derived neurotrophic factor mutant mice. FASEB J. 21, 1994-2004, 2007.
  13. Mizoguchi H, Yamada K, Mouri A, Niwa M, Mizuno T, Noda Y, Nitta A, Itohara S, Banno Y and Nabeshima T: Role of matrix metalloproteinase and tissue inhibitor of MMP in methamphetamine-induced behavioral sensitization and reward: implication for dopamine receptor down-regulation and dopamine release. J. Neurochem. 102, 1548-1560, 2007.
  14. Nagai T, Takuma K, Dohniwa M, Ibi D, Mizoguchi H, Kamei H, Nabeshima T and Yamada K: Repeated methamphetamine treatment impairs spatial working memory in rats: reversal by clozapine but not haloperidol. Psychopharmacology (Berl) 194, 21-32, 2007.
  15. Takuma K, Hoshina, Y, Arai S, Himeno Y, Matsuo, A, Funatsu Y, Kitahara Y, Ibi, D, Hayase M, Kamei H, Mizoguchi H, Nagai T, Koike K, Inoue M and Yamada K: Ginkgo biloba extract EGb761 attenuates hippocampal neuronal loss and cognitive dysfunction resulting from chronic restraint stress in ovariectomized rats. Neuroscience 149, 256-262, 2007.
  16. Takano K, Kitao Y, Tabata Y, Miura H, Sato K, Takuma K, Yamada K, Hibino S, Choshi T, Iinuma M, Suzuki H, Murakami R, Yamada M, Ogawa S and Hori O: A dibenzoylmethane (DBM) derivative protects dopaminergic neurons against both oxidative stress and endoplasmic reticulum (ER) stress. Am. J. Physiol.Cell Physiol. 293, 1884-1894, 2007.
  17. Ito M, Nagai T, Mizoguchi H, Sato K, Hayase M, Otsuka N, Fukakusa A, Kumagai N, Kim H-C, Nabeshima T, Takuma K and Yamada K: Activation of post-synaptic dopamine D1 receptors promotes the release of tissue plasminogen activator in the nucleus accumbens via PKA signaling. J. Neurochem. 103, 2589-2596, 2007.
  18. Shin EJ, Jeong JH, Kim HJ, Jang CG, Yamada K, Nabeshima T and Kim HC: Exposure to extremely low frequency magnetic fields enhances locomotor activity via activation of dopamine D1-like receptors in mice. J. Pharmacol. Sci. 105, 367-371, 2007.
  19. Niwa M, Nitta A, Yamada K and Nabeshima T: The roles of glial cell line-derived neurotrophic factor, tumor necrosis factor-?, and an inducer of these factors in drug dependence [review]. J. Pharmacol. Sci. 104, 116-121, 2007.

総説（欧文）

2019年

  1. Mizoguchi H, Yamada K: Methamphetamine use causes cognitive impairment and altered decision-making. Neurochem Int. 124: 106-113,2019.(doi: 10.1016/j.neuint.2018.12.019.., 2019.)

2017年

  1. Caraci F, Enna SJ, Zohar J, Racagni G, Zalsman G, van den Brink W, Kasper S, Koob GF, Pariante CM, Piazza PV, Yamada K, Spedding M, Drago F: A new nomenclature for classifying psychotropic drugs. Birt J Clin Pharmacol. 83:1614-1616, 2017.

  2. Shin EJ, Dang DK, The-Vinh Tran TV, Tan HQ, Ji Hoon Jeong JH, Nah SY, Jang CG, Yamada K, Nabeshima T, Kim HC: Current understanding of methamphetamine-associated dopaminergic neurodegeneration and psychotoxic behaviors. Arch Pharm Res. 40: 403-428, 2017. DOI 10.1007/s12272-017-0897-y.

2016年

  1. Itoh N, Enomoto A, Nagai T, Takahashi M, Yamada K: Molecular mechanism linking BDNF/TrkB signaling with the NMDA receptor in memory: The role of Girdin in the CNS. Rev Neurosci. 27:481-90, 2016.
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