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論文 A03

A03-1

  1. Ishikawa KI, Yamaguchi A, Okano H, Akamatsu W. Assessment of Mitophagy in iPS Cell-Derived Neurons.Methods Mol Biol. 2017 Mar 22. doi: 10.1007/7651_2017_10. [Epub ahead of print] [PubMed]
  2. Nakazawa T, Kikuchi M, Ishikawa M, Yamamori H, Nagayasu K, Matsumoto T, Fujimoto M, Yasuda Y, Fujiwara M, Okada S, Matsumura K, Kasai A, Hayata-Takano A, Shintani N, Numata S, Takuma K, Akamatsu W, Okano H, Nakaya A, Hashimoto H, Hashimoto R. Differential gene expression profiles in neurons generated from lymphoblastoid B-cell line-derived iPS cells from monozygotic twin cases with treatment-resistant schizophrenia and discordant responses to clozapine.Schizophr Res. 2017 Mar; 181:75-82. doi: 10.1016/j.schres.2016.10.012. Epub 2016 Oct 27. [PubMed]
  3. Hikishima K, Komaki Y, Seki F, Ohnishi Y, Okano HJ, Okano H. In vivo microscopic voxel-based morphometry with a brain template to characterize strain-specific structures in the mouse brain.Sci Rep. 2017 Dec;7(1):85. doi: 10.1038/s41598-017-00148-1. Epub 2017 Mar 7. [PubMed]
  4. Itakura G, Kawabata S, Ando M, Nishiyama Y, Sugai K, Ozaki M, Iida T, Ookubo T, Kojima K, Kashiwagi R, Yasutake K, Nakauchi H, Miyoshi H, Nagoshi N, Kohyama J, Iwanami A, Matsumoto M, Nakamura M, Okano H. Fail-Safe System against Potential Tumorigenicity after Transplantation of iPSC Derivatives.Stem Cell Reports. 2017 Mar 14;8(3): 673-684. doi: 10.1016/j.stemcr.2017.02.003. Epub 2017 Mar 2. [PubMed]
  5.  Tashiro S, Nakamura M, Okano H. The prospects of regenerative medicine combined with rehabilitative approaches for chronic spinal cord injury animal models.Neural Regen Res. 2017 Jan;12(1):43-46. doi: 10.4103/1673-5374.198972. Review. [PubMed]
  6. Nakatsuji H, Araki A, Hashizume A, Hijikata Y, Yamada S, Inagaki T, Suzuki K, Banno H, Suga N, Okada Y, Ohyama M, Nakagawa T, Kishida K, Funahashi T, Shimomura I, Okano H, Katsuno M, Sobue G. Correlation of insulin resistance and motor function in spinal and bulbar muscular atrophy.J Neurol. 2017 Feb 22. doi: 10.1007/s00415-017-8405-3. [Epub ahead of print] [PubMed]
  7. Veraitch O, Mabuchi Y, Matsuzaki Y, Sasaki T, Okuno H, Tsukashima A, Amagai M, Okano H, Ohyama M. Induction of hair follicle dermal papilla cell properties in human induced pluripotent stem cell-derived multipotent LNGFR (+)THY-1(+) mesenchymal cells.Sci Rep. 2017 Feb 21;7 :42777. doi: 10.1038/srep42777. [PubMed]
  8. Takano M, Kawabata S, Shibata S, Yasuda A, Nori S, Tsuji O, Nagoshi N, Iwanami A, Ebise H, Horiuchi K, Okano H, Nakamura M. Enhanced Functional Recovery from Spinal Cord Injury in Aged Mice after Stem Cell Transplantation through HGF Induction.Stem Cell Reports. 2017 Feb 6. pii: S2213-6711(17)30028-0. doi: 10.1016/j.stemcr.2017.01.013. [Epub ahead of print] [PubMed].
  9. Sato R, Nakano T, Hosonaga M, Sampetrean O, Harigai R, Sasaki T, Koya I, Okano H, Kudoh J, Saya H, Arima Y. RNA Sequencing Analysis Reveals Interactions between Breast Cancer or Melanoma Cells and the Tissue Microenvironment during Brain Metastasis.Biomed Res Int. 2017; 2017:8032910. doi: 10.1155/2017/8032910.　[PubMed]
  10. Nagoshi N, Okano H. Applications of induced pluripotent stem cell technologies in spinal cord injury.J Neurochem. 2017 Feb 15. doi: 10.1111/jnc.13986. [Epub ahead of print] Review.　[PubMed]
  11. Inagaki E, Hatou S, Higa K, Yoshida S, Shibata S, Okano H, Tsubota K, Shimmura S. Skin-Derived Precursors as a Source of Progenitors for Corneal Endothelial Regeneration.Stem Cells Transl Med. 2017 Feb 6. doi: 10.1002/sctm.16-0162. [Epub ahead of print]　[PubMed]
  12. Ishigaki S, Fujioka Y, Okada Y, Riku Y, Udagawa T, Honda D, Yokoi S, Endo K, Ikenaka K, Takagi S, Iguchi Y, Sahara N, Takashima A, Okano H, Yoshida M, Warita H, Aoki M, Watanabe H, Okado H, Katsuno M, Sobue G. Altered Tau Isoform Ratio Caused by Loss of FUS and SFPQ Function Leads to FTLD-like Phenotypes.Cell Rep. 2017 Jan 31; 18(5):1118-1131. doi: 10.1016/j.celrep.2017.01.013.　[PubMed]
  13. Tsutsui-Kimura I, Takiue H, Yoshida K, Xu M, Yano R, Ohta H, Nishida H, Bouchekioua Y, Okano H, Uchigashima M, Watanabe M, Takata N, Drew MR, Sano H, Mimura M, Tanaka KF. Dysfunction of ventrolateral striatal dopamine receptor type 2-expressing medium spiny neurons impairs instrumental motivation.Nat Commun. 2017 Feb 1;8:14304. doi: 10.1038/ncomms14304.　[PubMed]
  14. Iida T, Iwanami A, Sanosaka T, Kohyama J, Miyoshi H, Nagoshi N, Kashiwagi R, Toyama Y, Matsumoto M, Nakamura M, Okano H. Whole-Genome DNA Methylation Analyses Revealed Epigenetic Instability in Tumorigenic Human iPS Cell-Derived Neural Stem/Progenitor Cells.Stem Cells. 2017 Jan 31. doi: 10.1002/stem.2581. [Epub ahead of print]　[PubMed]
  15. Kobayashi M, Sumiyama K, Shimojima N, Shimojima N, Ieiri S, Okano H, Kamba S, Fujimura T, Hirobe S, Kuroda T, Takahashi-Fujigasaki J. Technical Feasibility of Visualizing Myenteric Plexus Using Confocal Laser Endomicroscopy.J Gastroenterol Hepatol. 2017 Jan 31. doi: 10.1111/jgh.13754. [Epub ahead of print]　[PubMed]
  16. Ozaki M, Iwanami A, Nagoshi N, Kohyama J, Itakura G, Iwai H, Nishimura S, Nishiyama Y, Kawabata S, Sugai K, Iida T, Matsubayashi K, Isoda M, Kashiwagi R, Toyama Y, Matsumoto M, Okano H, Nakamura M. Evaluation of the immunogenicity of human iPS cell-derived neural stem/progenitor cells in vitro.Stem Cell Res. 2017 Jan 19; 19:128-138. doi: 10.1016/j.scr.2017.01.007. [Epub ahead of print]　[PubMed]
  17. Takayama Y, Wakabayashi T, Kushige H, Saito Y, Shibuya Y, Shibata S, Akamatsu W, Okano H, Kida YS. Brief exposure to small molecules allows induction of mouse embryonic fibroblasts into neural crest-like precursors.FEBS Lett. 2017 Jan 27. doi: 10.1002/1873-3468.12572. [Epub ahead of print]　[PubMed]
  18. Andoh-Noda T, Akamatsu W, Miyake K, Kobayashi T, Ohyama M, Kurosawa H, Kubota T, Okano H. Differential X Chromosome Inactivation Patterns during the Propagation of Human Induced Pluripotent Stem Cells.Keio J Med. 2017 Jan 20. doi: 10.2302/kjm.2016-0015-OA. [Epub ahead of print]　[PubMed]
  19. Tanikawa M, Nakahara J, Hata J, Suzuki S, Fujiyoshi K, Fujiwara H, Momoshima S, Jinzaki M, Nakamura M, Okano H, Takahashi S, Suzuki N.q-Space Myelin Map imaging for longitudinal analysis of demyelination and remyelination in multiple sclerosis patients treated with fingolimod: A preliminary study.J Neurol Sci. Commun. 2017 Feb 15;373:352-357. doi: 10.1016/j.jns.2017.01.009.　[PubMed]
  20. Suzuki S, Akamatsu W, Kisa F, Sone T, Ishikawa KI, Kuzumaki N, Katayama H, Miyawaki A, Hattori N, Okano H.Efficient induction of dopaminergic neuron differentiation from induced pluripotent stem cells reveals impaired mitophagy in PARK2 neurons.Biochem Biophys Res Commun. 2017 Jan 29;483(1):88-93. doi: 10.1016/j.bbrc.2016.12.188.　[PubMed]
  21. Hosoya M, Fujioka M, Sone T, Okamoto S, Akamatsu W, Ukai H, Ueda HR, Ogawa K, Matsunaga T, Okano H. Cochlear Cell Modeling Using Disease-Specific iPSCs Unveils a Degenerative Phenotype and Suggests Treatments for Congenital Progressive Hearing Loss.Cell Rep. 2017 Jan 3; 18(1):68-81. doi: 10.1016/j.celrep.2016.12.020. [PubMed]
  22. Yamazaki K, Fukushima K, Sugawara M, Tabata Y, Imaizumi Y, Ishihara Y, Ito M, Tsukahara K, Kohyama J, Okano H. Functional Comparison of Neuronal Cells Differentiated from Human Induced Pluripotent Stem Cell-Derived Neural Stem Cells under Different Oxygen and Medium Conditions.J Biomol Screen. 2016 Dec;21(10):1054-1064. doi: 10.1177/1087057116661291.　[PubMed]
  23. Okuno H, Nakabayashi K, Abe K, Ando T, Sanosaka T, Kohyama J, Akamatsu W, Ohyama M, Takahashi T, Kosaki K, Okano H. Changeability of the fully methylated status of the 15q11.2 region in induced pluripotent stem cells derived from a patient with Prader-Willi syndrome.Congenit Anom(Kyoto). 2016 Dec 21. doi: 10.1111/cga.12206. [Epub ahead of print] [PubMed]
  24. Ohta S, Yaguchi T, Okuno H, Chneiweiss H, Kawakami Y, Okano H. CHD7 promotes proliferation of neural stem cells mediated by MIF.Mol Brain. 2016 Dec 13;9(1):96. [PubMed]
  25. Hoashi Y, Okamoto S, Abe Y, Matsumoto T, Tanaka J, Yoshida Y, Imaizumi K, Mishima K, Akamatsu W, Okano H, Baba K. Generation of neural cells using iPSCs from sleep bruxism patients with 5-HT2A polymorphism.J Prosthodont Res. 2016 Dec 1. pii: S1883-1958(16)30106-2. doi: 10.1016/j.jpor.2016.11.003. [Epub ahead of print] [PubMed]
  26. Komaki Y, Hikishima K, Shibata S, Konomi T, Seki F, Yamada M, Miyasaka N, Fujiyoshi K, Okano HJ, Nakamura M, Okano H. Functional brain mapping using specific sensory-circuit stimulation and a theoretical graph network analysis in mice with neuropathic allodynia.Sci Rep. 2016 Nov 29;6:37802. doi: 10.1038/srep37802. [PubMed]
  27. Sato Y, Mabuchi Y, Miyamoto K, Araki D, Niibe K, Houlihan DD, Morikawa S, Nakagawa T, Nakajima T, Akazawa C, Hori S, Okano H, Matsuzaki Y. Notch2 Signaling Regulates the Proliferation of Murine Bone Marrow-Derived Mesenchymal Stem/Stromal Cells via c-Myc Expression.PLoS One. 2016 Nov 17;11(11):e0165946. doi: 10.1371/journal.pone.0165946. [PubMed](in press)
  28. Okano H, Sasaki E, Yamamori T, Iriki A, Shimogori T, Yamaguchi Y, Kasai K, Miyawaki A. Brain/MINDS: A Japanese National Brain Project for Marmoset Neuroscience.Neuron. 2016 Nov 2; 92(3):582-590. doi: 10.1016/j.neuron.2016.10.018. [PubMed]
  29. Yoshida K, Mimura Y, Ishihara R, Nishida H, Komaki Y, Minakuchi T, Tsurugizawa T, Mimura M, Okano H, Tanaka KF, Takata N. Physiological effects of a habituation procedure for functional MRI in awake mice using a cryogenic radiofrequency probe.J Neurosci Methods. 2016 Oct 1. pii: S0165-0270(16)30222-9. doi: 10.1016/j.jneumeth.2016.09.013. [PubMed]
  30. Sugio S, Tohyama K, Oku S, Fujiyoshi K, Yoshimura T, Hikishima K, Yano R, Fukuda T, Nakamura M, Okano H, Watanabe M, Fukata M, Ikenaka K, F Tanaka K. Astrocyte-mediated infantile-onset leukoencephalopathy mouse model.Glia. 2016 Oct 17. doi: 10.1002/glia.23084. [PubMed]
  31. Fujimori K, Tezuka T, Ishiura H, Mitsui J, Doi K, Yoshimura J, Tada H, Matsumoto T, Isoda M, Hashimoto R, Hattori N, Takahashi T, Morishita S, Tsuji S, Akamatsu W, Okano H. Modeling neurological diseases with induced pluripotent cells reprogrammed from immortalized lymphoblastoid cell lines.Mol Brain. 2016 Oct 3; 9(1):88. [PubMed]
  32. Okubo T, Iwanami A, Kohyama J, Itakura G, Kawabata S, Nishiyama Y, Sugai K, Ozaki M, Iida T, Matsubayashi K, Matsumoto M, Nakamura M, Okano H. Pretreatment with a γ-Secretase Inhibitor Prevents Tumor-like Overgrowth in Human iPSC-Derived Transplants for Spinal Cord Injury.Stem Cell Reports. 2016 Sep 15. pii: S2213-6711(16)30182-5. doi: 10.1016/j.stemcr.2016.08.015. [Epub ahead of print][PubMed]
  33. Imamura T, Fujita K, Tagawa K, Ikura T, Chen X, Homma H, Tamura T, Mao Y, Taniguchi JB, Motoki K, Nakabayashi M, Ito N, Yamada K, Tomii K, Okano H, Kaye J, Finkbeiner S, Okazawa H. Identification of hepta-histidine as a candidate drug for Huntington’s disease by in silico-in vitro- in vivo-integrated screens of chemical libraries.Sci Rep. 2016 Sep 22; 6:33861. doi: 10.1038/srep33861. [PubMed]
  34. Nakajima R, Okano H, Noce T. JMJD1C Exhibits Multiple Functions in Epigenetic Regulation during Spermatogenesis.PLoS One. 2016 Sep 20; 11(9): e0163466. doi: 10.1371/journal.pone.0163466. eCollection 2016. [PubMed]
  35. Sugai K, Fukuzawa R, Shofuda T, Fukusumi H, Kawabata S, Nishiyama Y, Higuchi Y, Kawai K, Isoda M, Kanematsu D, Hashimoto-Tamaoki T, Kohyama J, Iwanami A, Suemizu H, Ikeda E, Matsumoto M, Kanemura Y, Nakamura M, Okano H. Pathological classification of human iPSC-derived neural stem/progenitor cells towards safety assessment of transplantation therapy for CNS diseases.Mol Brain. 2016 Sep 19;9(1):85. doi: 10.1186/s13041-016-0265-8. [PubMed]
  36. Cheung LY, Okano H, Camper SA. Sox21 deletion in mice causes postnatal growth deficiency without physiological disruption of hypothalamic-pituitary endocrine axes.Mol Cell Endocrinol. 2016 Sep 8. pii: S0303-7207(16)30370-7. doi: 10.1016/j.mce.2016.09.005. [Epub ahead of print] [PubMed]
  37. Grillner S, Ip N, Koch C, Koroshetz W, Okano H, Polachek M, Poo MM, Sejnowski TJ. Worldwide initiatives to advance brain research.Nat Neurosci. 2016 Aug 26; 19(9):1118-22. doi: 10.1038/nn.4371. [PubMed]
  38. Yamazaki Y, Hikishima K, Saiki M, Inada M, Sasaki E, Lemon RN, Price CJ, Okano H, Iriki A. Neural changes in the primate brain correlated with the evolution of complex motor skills.Sci Rep. 2016 Aug 8; 6:31084. doi: 10.1038/srep31084. [PubMed]
  39. Shinozaki M, Iwanami A, Fujiyoshi K, Tashiro S, Kitamura K, Shibata S, Fujita H, Nakamura M, Okano H. Combined treatment with chondroitinase ABC and treadmill rehabilitation for chronic severe spinal cord injury in adult rats.Neurosci Res. 2016 Aug 4. pii: S0168-0102(16)30108-0. doi: 10.1016/j.neures.2016.07.005. [Epub ahead of print] [PubMed]
  40. Tashiro S, Nishimura S, Iwai H, Sugai K, Zhang L, Shinozaki M, Iwanami A, Toyama Y, Liu M, Okano H, Nakamura M. Functional Recovery from Neural Stem/Progenitor Cell Transplantation Combined with Treadmill Training in Mice with Chronic Spinal Cord Injury.Sci Rep. 2016 Aug 3; 6:30898. doi: 10.1038/srep30898. [PubMed]
  41. Harada K, Ferdous T, Cui D, Kuramitsu Y, Matsumoto T, Ikeda E, Okano H, Ueyama Y. Induction of artificial cancer stem cells from tongue cancer cells by defined reprogramming factors.BMC Cancer. 2016 Jul 27; 16:548. doi: 10.1186/s12885-016-2416-9. [PubMed]
  42. Bamba Y, Shofuda T, Kato M, Pooh RK, Tateishi Y, Takanashi J, Utsunomiya H, Sumida M, Kanematsu D, Suemizu H, Higuchi Y, Akamatsu W, Gallagher D, Miller FD, Yamasaki M, Kanemura Y, Okano H. In vitro characterization of neurite extension using induced pluripotent stem cells derived from lissencephaly patients with TUBA1A missense mutations.Mol Brain. 2016 Jul 19; 9(1): 70. doi: 10.1186/s13041-016-0246-y. [PubMed]
  43. Hosoya M, Fujioka M, Okano H, Ogawa K. Distinct Expression Pattern of a Deafness Gene, KIAA1199, in a Primate Cochlea.Biomed Res Int. 2016; 2016:1781894. doi: 10.1155/2016/1781894. Epub 2016 Jun 14. [PubMed]
  44.  Sato K, Oiwa R, Kumita W, Henry R, Sakuma T, Ito R, Nozu R, Inoue T, Katano I, Sato K, Okahara N, Okahara J, Shimizu Y, Yamamoto M, Hanazawa K, Kawakami T, Kametani Y, Suzuki R, Takahashi T, Weinstein EJ, Yamamoto T, Sakakibara Y, Habu S, Hata JI, Okano H, Sasaki E. Generation of a Nonhuman Primate Model of Severe Combined Immunodeficiency Using Highly Efficient Genome Editing.Cell Stem Cell. 2016 Jun 29. pii: S1934-5909(16)30153-9. doi: 10.1016/j.stem.2016.06.003. [Epub ahead of print] 【PubMed】
  45. Suzuki N, Hosoya M, Oishi N, Okano H, Fujioka M, Ogawa K. Expression pattern of wolframin, the WFS1 (Wolfram syndrome-1 gene) product, in common marmoset (Callithrix jacchus) cochlea.Neuroreport. 2016 Jun 23. [Epub ahead of print]PMID :27341211 【PubMed】
  46. Hara Y, Motoi Y, Hikishima K, Mizum H, Onoe H, Matsumoto SE, Elahi M, Okano H, Aoki S, Hattori N. Involvement of the septo-hippocampal cholinergic pathway in association with septal acetylcholinesterase upregulation in a mouse model of tauopathy.Curr Alzheimer Res. 2016 Jun 2. [Epub ahead of print] PMID: 27335039 【PubMed】
  47. Fox RG, Lytle NK, Jaquish DV, Park FD, Ito T, Bajaj J, Koechlein CS, Zimdahl B, Yano M, Kopp JL, Kritzik M, Sicklick JK, Sander M, Grandgenett PM, Hollingsworth MA, Shibata S, Pizzo D, Valasek MA, Sasik R, Scadeng M, Okano H, Kim Y, MacLeod AR, Lowy AM, Reya T. Image-based detection and targeting of therapy resistance in pancreatic adenocarcinoma.Nature. 2016 Jun 6. doi: 10.1038/nature17988. [Epub ahead of print] PMID: 27281208【PubMed】
  48. Kunitomi A, Yuasa S, Sugiyama F, Saito Y, Seki T, Kusumoto D, Kashimura S, Takei M, Tohyama S, Hashimoto H, Egashira T, Tanimoto Y, Mizuno S, Tanaka S, Okuno H, Yamazawa K, Watanabe H, Oda M, Kaneda R, Matsuzaki Y, Nagai T, Okano H, Yagami KI, Tanaka M, Fukuda K. H1foo Has a Pivotal Role in Qualifying Induced Pluripotent Stem Cells.Stem Cell Reports. 2016 May 20. pii: S2213-6711(16)30040-6. doi: 10.1016/j.stemcr.2016.04.015. [Epub ahead of print] PMID: 27237376 【PubMed】
  49. Fukusumi H, Shofuda T, Bamba Y, Yamamoto A, Kanematsu D, Handa Y, Okita K, Nakamura M, Yamanaka S, Okano H, Kanemura Y. Establishment of Human Neural Progenitor Cells from Human Induced Pluripotent Stem Cells with Diverse Tissue Origins.Stem Cells Int. 2016; 2016:7235757. doi: 10.1155/2016/7235757. Epub 2016 Apr 26. PMID: 27212953 【PubMed】
  50. Narumi S, Amano N, Ishii T, Katsumata N, Muroya K, Adachi M, Toyoshima K, Tanaka Y, Fukuzawa R, Miyako K, Kinjo S, Ohga S, Ihara K, Inoue H, Kinjo T, Hara T, Kohno M, Yamada S, Urano H, Kitagawa Y, Tsugawa K, Higa A, Miyawaki M, Okutani T, Kizaki Z, Hamada H, Kihara M, Shiga K, Yamaguchi T, Kenmochi M, Kitajima H, Fukami M, Shimizu A, Kudoh J, Shibata S, Okano H, Miyake N, Matsumoto N, Hasegawa T. SAMD9 mutations cause a novel multisystem disorder, MIRAGE syndrome, and are associated with loss of chromosome 7.Nat Genet. 2016 May 16. doi: 10.1038/ng.3569. [Epub ahead of print] PMID: 27182967 【PubMed】
  51. Ouchi T, Morikawa S, Shibata S, Fukuda K, Okuno H, Fujimura T, Kuroda T, Ohyama M, Akamatsu W, Nakagawa T, Okano H. LNGFR+THY-1+ human pluripotent stem cell-derived neural crest-like cells have the potential to develop into mesenchymal stem cells.Differentiation. 2016 May 10. pii: S0301-4681(15)30062-1. doi:10.1016/j.diff.2016.04.003. [Epub ahead of print] PMID: 27178356 【PubMed】
  52. Miyawaki S, Kawamura Y, Oiwa Y, Shimizu A, Hachiya T, Bono H, Koya I, Okada Y, Kimura T, Tsuchiya Y, Suzuki S, Onishi N, Kuzumaki N, Matsuzaki Y, Narita M, Ikeda E, Okanoya K, Seino K, Saya H, Okano H, Miura K. Tumour resistance in induced pluripotent stem cells derived from naked mole-rats.Nat Commun. 2016 May 10;7:11471. doi: 10.1038/ncomms11471. PMID:27161380【PubMed】
  53. Bertolin AP, Katz MJ, Yano M, Pozzi B, Acevedo JM, Blanco-Obregón D, Gándara L, Sorianello E, Kanda H, Okano H, Srebrow A, Wappner P.　Musashi mediates translational repression of the Drosophila hypoxia inducible factor.Nucleic Acids Res. 2016 May 3. pii: gkw372. [Epub ahead of print]PMID:27141964【PubMed】
  54. Fox RG, Lytle NK, Park FD, Bajaj J, Koechlein CS, Yano M, Ito T, Kopp J, Kritzik M, Sicklick J, Sander M, Grandgenett PM, Hollingsworth MA, Shibata S, Pizzo D, Valasek M, Sasik R, Scadeng M, Okano H, Kim Y, MacLeod AR, Lowy AM and Reya T: Image based identification and targeting of cancer stem cells in pancreatic adenocarcinoma.Nature, 2016. (in press)
  55. Inagaki Y, Fujioka M, Kanzaki S, Watanabe K, Oishi N, Itakura G, Yasuda A, Shibata S, Nakamura M, Okano HJ, Okano H, Ogawa K. Sustained Effect of Hyaluronic Acid in Subcutaneous Administration to the Cochlear Spiral Ganglion.PLoS One. 2016 Apr 21;11(4):e0153957. doi: 10.1371/journal.pone.0153957. eCollection 2016.PMID: 27099926 【PubMed】
  56. Hosoya M, Fujioka M, Kobayashi R, Okano H, Ogawa K. Overlapping expression of anion exchangers in the cochlea of a non-human primate suggests functional compensation.Neurosci Res. 2016 Apr 18. pii: S0168-0102(16)30006-2. doi: 10.1016/j.neures.2016.04.002. [Epub ahead of print] PMID: 27091614 【PubMed】
  57. Isoda M, Kohyama J, Iwanami A, Sanosaka T, Sugai K, Yamaguchi R, Matsumoto T, Nakamura M, Okano H. Robust production of human neural cells by establishing neuroepithelial-like stem cells from peripheral blood mononuclear cell-derived feeder-free iPSCs under xeno-free conditions.Neurosci Res. 2016 Apr 12. pii: S0168-0102(16)30007-4. doi: 10.1016/j.neures.2016.04.003. [Epub ahead of print] PMID: 27083781 【PubMed】
  58. Andoh-Noda T, Inouye MO, Miyake K, Kubota T, Okano H, Akamatsu W. Modeling Rett syndrome using human induced pluripotent stem cells.CNS Neurol Disord Drug Targets. 2016 Apr 13. [Epub ahead of print] PMID: 27071793 【PubMed】
  59. Fox RG, Lytle NK, Park FD, Bajaj J, Koechlein CS, Yano M, Ito T, Kopp J, Kritzik M, Sicklick J, Sander M, Grandgenett PM, Hollingsworth MA, Shibata S, Pizzo D, Valasek M, Sasik R, Scadeng M, Okano H, Kim Y, MacLeod AR, Lowy AM and Reya T: Image based identification and targeting of cancer stem cells in pancreatic adenocarcinoma.Nature, 2016. (in press)
  60. Miyawaki S, Kawamura Y, Oiwa Y, Shimizu A, Hachiya T, Bono H, Koya I, Okada Y, Kimura T, Tsuchiya Y, Suzuki S, Onishi N, Kuzumaki N, Matsuzaki Y, Narita M, Eiji Ikeda E, Kazuo Okanoya K, Seino KI, Saya H, Okano H and Miura K: Tumour resistance in induced pluripotent stem cells derived from naked mole-rats.Nature Communication, 2016. (in press)
  61. Narumi S., Amano, S., Okano H., Miyake N, Hasegawa T. et al.: SAMD9 mutations cause a novel multisystem disorder (MIRAGE syndrome) and are associated with loss of chromosome 7.Nature Genetics, 2016. (In Press)
  62. Bertolin AP, Katz MJ, Yano M, Pozzi B, Acevedo JM, Blanco-Obregón D, Gándara　L, Sorianello E, Kanda H, Okano H, Srebrow A, Wappner P.: Musashi mediates translational repression of the Drosophila hypoxia inducible factor.Nucleic Acids Res. 2016 May 3. pii: gkw372. [Epub ahead of print]
  63. Ouchi T, Morikawa S, Shibata S, Fukuda K, Okuno H, Fujimura T, Ohyama M, Akamatsu W, Nakagawa T, Okano H.: LNGFR+THY-1+ human pluripotent stem cells-derived neural crest-like cells have potential to develop into mesenchymal stem cells.Differentiation, 2016. (In Press)
  64. Bamba Y, Shofuda T, Kato M, Ritsuko K. Pooh RK, Kanemura Y, Okano H et al..: In vitro characterization of neurite extension using induced pluripotent stem cells derived from lissencephaly patients with TUBA1A missense mutations.Mol Brain, 2016. (In Press)
  65. Shimazaki T, Okano H. Heterochronic microRNAs in temporal specification of neural stem cells: application toward rejuvenation.Aging and Mechanism of Disease.2016;2, 15014.
  66. Isoda M, Kohyama J, Iwanami A, Sanosaka T, Sugai K, Yamaguchi R, Matsumoto T, Nakamura M, Okano H. Robust production of human neural cells by establishing neuroepithelial-like stem cells from peripheral blood mononuclear cell-derived feeder-free iPSCs under xeno-free conditions.Neurosci Res. 2016 Apr 12. [Epub ahead of print] PMID: 27083781.
  67. Andoh-Noda T, Inouye MO, Miyake K, Kubota T, Okano H, Akamatsu W. Modeling Rett syndrome using human induced pluripotent stem cells.CNS Neurol Disord Drug Targets. 2016.[Epub ahead of print] PMID: 27071793.
  68. Hosoya M, Fujioka M, Kobayashi R, Okano H, Ogawa K. Overlapping expression of anion exchangers in the cochlea of a non-human primate suggests functional compensation.Neurosci Res. 2016. [Epub ahead of print] PMID: 27091614.
  69. Inagaki Y, Fujioka M, Kanzaki S, Watanabe K, Oishi N, Itakura G, Yasuda A, Shibata S, Nakamura M, Okano HJ, Okano H, Ogawa K. Sustained Effect of Hyaluronic Acid in Subcutaneous Administration to the Cochlear Spiral Ganglion.PLoS One. 2016;11(4):e0153957. 2016.
  70. Fujiyoshi K, Hikishima K, Nakahara J, Tsuji O, Hata J, Konomi T, Nagai T, Shibata S, Kaneko S, Iwanami A, Momoshima S, Takahashi S, Jinzaki M, Suzuki N, Toyama Y, Nakamura M, Okano H. Application of q-Space Diffusion MRI for the Visualization of White Matter.J Neurosci. 2016;36(9):2796-808.
  71. Fujimura T, Shibata S, Shimojima N, Morikawa Y, Okano H, Kuroda T. Fluorescence Visualization of the Enteric Nervous Network in a Chemically Induced Aganglionosis Model.PLoS One. 2016;11(3):e0150579.
  72. chiyanagi N, Fujimori K, Yano M, Ishihara-Fujisaki C, Sone T, Akiyama T, Okada Y, Akamatsu W, Matsumoto T, Ishikawa M, Nishimoto Y, Ishihara Y, Sakuma T, Yamamoto T, Tsuiji H, Suzuki N, Warita H, Aoki M, Okano H. Establishment of In Vitro FUS-Associated Familial Amyotrophic Lateral Sclerosis Model Using Human Induced Pluripotent Stem Cells.Stem Cell Reports. 2016;6(4):496-510. 2016.
  73. Fukaya R, Ohta S, Yaguchi T, Matsuzaki Y, Sugihara E, Okano H, Saya H, Kawakami Y, Kawase T, Yoshida K, Toda M. MIF maintains the tumorigenic capacity of brain tumor-initiating cells by directly inhibiting p53.Cancer Res. 2016;pii: canres.1011.2015. [Epub ahead of print] PMID: 26980763.
  74. Hosoya M, Fujioka M, Ogawa K, Okano H. Distinct Expression Patterns Of Causative Genes Responsible For Hereditary Progressive Hearing Loss In Non-Human Primate Cochlea.Sci Rep. 2016;6:22250.
  75. Matsumoto T, Fujimori K, Andoh-Noda T, Ando T, Kuzumaki N, Toyoshima M, Tada H, Imaizumi K, Ishikawa M, Yamaguchi R, Isoda M, Zhou Z, Sato S, Kobayashi T, Ohtaka M, Nishimura K, Kurosawa H, Yoshikawa T, Takahashi T, Nakanishi M, Ohyama M, Hattori N, Akamatsu W, Okano H. Functional Neurons Generated from T Cell-Derived Induced Pluripotent Stem Cells for Neurological Disease Modeling.Stem Cell Reports. 2016;6(3):422-35.
  76. Morikawa S, Ouchi T, Shibata S, Fujimura T, Kawana H, Okano H, Nakagawa T. Applications of Mesenchymal Stem Cells and Neural Crest Cells in Craniofacial Skeletal Research.Stem Cells Int. 2016;2016:2849879.
  77. Maekawa M, Iwayama Y, Ohnishi T, Toyoshima M, Shimamoto C, Hisano Y, Toyota T, Balan S, Matsuzaki H, Iwata Y, Takagai S, Yamada K, Ota M, Fukuchi S, Okada Y, Akamatsu W, Tsujii M, Kojima N, Owada Y, Okano H, Mori N, Yoshikawa T. Erratum: Investigation of the fatty acid transporter-encoding genes SLC27A3 and SLC27A4 in autism.Sci Rep. 2016;6:20268.
  78. Ogawa Y, Morikawa S, Okano H, Mabuchi Y, Suzuki S, Yaguchi T, Sato Y, Mukai S, Yaguchi S, Inaba T, Okamoto S, Kawakami Y, Tsubota K, Matsuzaki Y, Shimmura S. MHC-compatible bone marrow stromal/stem cells trigger fibrosis by activating host T cells in a scleroderma mouse model.Elife . 2016;5.
  79. Nishiyama Y, Iwanami A, Kohyama J, Itakura G, Kawabata S, Sugai K, Nishimura S, Kashiwagi R, Yasutake K, Isoda M, Matsumoto M, Nakamura M, Okano H. Safe and efficient method for cryopreservation of human induced pluripotent stem cell-derived neural stem and progenitor cells by a programmed freezer with a magnetic field.Neurosci Res. 2016. [Epub ahead of print] PMID:26804710.
  80. Yano M, Hayakawa-Yano Y, Okano H. RNA Regulation went wrong in neurodevelopmental disorders: the example of Msi/Elav RNA binding proteins.Int J Dev Neurosci. 2016;[Epub ahead of print] PMID:26796049.
  81. Hasegawa M, Hara-Miyauchi C, Ohta H, Sakimura K, Okano H, Okano HJ. Analysis of RNA metabolism in peripheral WBCs of TDP-43 KI mice identifies novel biomarkers of ALS.Neurosci Res. 2016;106:12-22.
  82. Kobayashi R, Takahashi-Fujigasaki J, Shiozawa S, Hara-Miyauchi C, Inoue T, Okano HJ, Sasaki E, Okano H. α-synuclein aggregation in the olfactory bulb of middle-aged common marmoset.Neurosci Res. 2016;106:55-61.
  83. Lin ZY, Hikabe O, Suzuki S, Hirano T, Siomi H, Sasaki E, Imamura M, Okano H. Sphere-formation culture of testicular germ cells in the common marmoset, a small New World monkey.Primates. 2016;57(1):129-35.
  84. Yasui T, Mabuchi Y, Toriumi H, Ebine T, Niibe K, Houlihan DD, Morikawa S, Onizawa K, Kawana H, Akazawa C, Suzuki N, Nakagawa T, Okano H, Matsuzaki Y. Purified Human Dental Pulp Stem Cells Promote Osteogenic Regeneration.J Dent Res. 2016;95(2):206-14. 2016
  85. Grants JM, Ying LT, Yoda A, You CC, Okano H, Sawa H, Taubert S. The Mediator Kinase Module Restrains Epidermal Growth Factor Receptor Signaling and Represses Vulval Cell Fate Specification in Caenorhabditis elegans.Genetics. 2015;202(2):583-99.
  86. Kawabata S, Takano M, Numasawa-Kuroiwa Y, Itakura G, Kobayashi Y, Nishiyama Y, Sugai K, Nishimura S, Iwai H, Isoda M, Shibata S, Kohyama J, Iwanami A, Toyama Y, Matsumoto M, Nakamura M, Okano H. Grafted Human iPS Cell-Derived Oligodendrocyte Precursor Cells Contribute to Robust Remyelination of Demyelinated Axons after Spinal Cord Injury.Stem Cell Reports. 2015;6(1):1-8.
  87. Shimojo D, Onodera K, Doi-Torii Y, Ishihara Y, Hattori C, Miwa Y, Tanaka S, Okada R, Ohyama M, Shoji M, Nakanishi A, Doyu M, Okano H, Okada Y.　Rapid, efficient, and simple motor neuron differentiation from human pluripotent stem cells.Mol Brain.. 2015;8(1):79.
  88. Sato K, Kuroki Y, Kumita W, Fujiyama A, Toyoda A, Kawai J, Iriki A, Sasaki E, Okano H, Sakakibara Y. Resequencing of the common marmoset genome improves genome assemblies and gene-coding sequence analysis.Sci Rep . 2015;5:16894.
  89. Yamada I, Hikishima K, Miyasaka N, Kato K, Kojima K, Kawano T, Ito E, Kobayashi D, Eishi Y, Okano H. Gastric carcinoma: evaluation with diffusion-tensor MR imaging and tractography ex vivo.Magn Reson Imaging. 2015.
  90. Nakata M, Yamamoto S, Okada T, Darambazar G, Okano H, Ozawa K, Yada T. IL-10 gene transfer upregulates arcuate POMC and ameliorates hyperphagia, obesity and diabetes by substituting for leptin.Int J Obes(Lond). 2015 Oct 5. doi: 10.1038/ijo.2015.201. [Epub ahead of print]
  91. Kanzaki S, Watanabe K, Fujioka M, Shibata S, Nakamura M, Okano HJ, Okano H, Ogawa K. Novel in vivo imaging analysis of an inner ear drug delivery system: drug availability in inner ear following different dose of systemic drug injections.Hear Res. 2015;330(Pt A):142-6.
  92. Imaizumi K, Sone T, Ibata K, Fujimori K, Yuzaki M, Akamatsu W, Okano H. Controlling the Regional Identity of hPSC-Derived Neurons to Uncover Neuronal Subtype Specificity of Neurological Disease Phenotypes.Stem Cell Reports. 2015;5(6):1010-22.
  93. Kohro Y, Sakaguchi E, Tashima R, Tozaki-Saitoh H, Okano H, Inoue K, Tsuda M. A new minimally-invasive method for microinjection into the mouse spinal dorsal horn.Sci Rep. 2015;5:14306.
  94. Yamada I, Hikishima K, Miyasaka N, Kato K, Ito E, Kojima K, Kawano T, Kobayashi D, Eishi Y, Okano H. q-space MR imaging of gastric carcinoma ex vivo: Correlation with histopathologic findings.Magn Reson Med. 2015. [Epub ahead of print] PMID: 26332305
  95. Ohtsuka T, Yano M, Okano H. Acute reduction of neuronal RNA binding Elavl2 protein and Gap43 mRNA in mouse hippocampus after kainic acid treatment.Biochem Biophys Res Commun. 2015;466(1):46-51. 2015.
  96. Shibata S, Murota Y, Nishimoto Y, Yoshimura M, Nagai T, Okano H, Siomi MC. Immuno-Electron Microscopy and Electron Microscopic In Situ Hybridization for Visualizing piRNA Biogenesis Bodies in Drosophila Ovaries.Methods Mol Biol. 2015;1328:163-78.
  97. Sugai K, Nishimura S, Kato-Negishi M, Onoe H, Iwanaga S, Toyama Y, Matsumoto M, Takeuchi S, Okano H, Nakamura M. Neural stem/progenitor cell-laden microfibers promote transplant survival in a mouse transected spinal cord injury model.J Neurosci Res. 2015;93(12):1826-38.
  98. Masuda H, Maruyama T, Gargett CE, Miyazaki K, Matsuzaki Y, Okano H, Tanaka M. Endometrial Side Population Cells: Potential Adult Stem/Progenitor Cells in Endometrium.Biol Reprod. 2015;93(4):84.
  99. Tsuyama J, Bunt J, Richards LJ, Iwanari H, Mochizuki Y, Hamakubo T, Shimazaki T, Okano H. MicroRNA-153 Regulates the Acquisition of Gliogenic Competence by Neural Stem Cells.Stem Cell Reports. 2015;5(3):365-77.
  100. Shiratori-Hayashi M, Koga K, Tozaki-Saitoh H, Kohro Y, Toyonaga H, Yamaguchi C, Hasegawa A, Nakahara T, Hachisuka J, Akira S, Okano H, Furue M, Inoue K, Tsuda M. STAT3-dependent reactive astrogliosis in the spinal dorsal horn underlies chronic itch.Nat Med. 2015;21(8):927-31.
  101. Yokota K, Kobayakawa K, Kubota K, Miyawaki A, Okano H, Ohkawa Y, Iwamoto Y, Okada S. Engrafted Neural Stem/Progenitor Cells Promote Functional Recovery through Synapse Reorganization with Spared Host Neurons after Spinal Cord Injury.Stem Cell Reports. 2015;5(2):264-77.
  102. Ono M, Kajitani T, Uchida H, Arase T, Oda H, Uchida S, Ota K, Nagashima T, Masuda H, Miyazaki K, Asada H, Hida N, Mabuchi Y, Morikawa S, Ito M, Bulun SE, Okano H, Matsuzaki Y, Yoshimura Y, Maruyama T. CD34 and CD49f Double-Positive and Lineage Marker-Negative Cells Isolated from Human Myometrium Exhibit Stem Cell-Like Properties Involved in Pregnancy-Induced Uterine Remodeling.Biol Reprod. 2015;93(2):37.
  103. Kondo T, Yoshihara Y, Yoshino-Saito K, Sekiguchi T, Kosugi A, Miyazaki Y, Nishimura Y, Okano HJ, Nakamura M, Okano H, Isa T, Ushiba J. Histological and electrophysiological analysis of the corticospinal pathway to forelimb motoneurons in common marmosets.Neurosci Res. 2015;98:35-44.
  104. Ohta E, Nihira T, Uchino A, Imaizumi Y, Okada Y, Akamatsu W, Takahashi K, Hayakawa H, Nagai M, Ohyama M, Ryo M, Ogino M, Murayama S, Takashima A, Nishiyama K, Mizuno Y, Mochizuki H, Obata F, Okano H. I2020T mutant LRRK2 iPSC-derived neurons in the Sagamihara family exhibit increased Tau phosphorylation through the AKT/GSK-3β signaling pathway.Hum Mol Genet. 2015;24(17):4879-900.
  105. Okano H, Miyawaki A, Kasai K. Brain/MINDS: brain-mapping project in Japan.Philos Trans R Soc Lond B Biol Sci. 2015;370(1668).
  106. Belmonte JC, Callaway EM, Churchland P, Caddick SJ, Feng G, Homanics GE, Lee KF, Leopold DA, Miller CT, Mitchell JF, Mitalipov S, Moutri AR, Movshon JA, Okano H, Reynolds JH, Ringach D, Sejnowski TJ, Silva AC, Strick PL, Wu J1, Zhang F. Brains, Genes, and Primates.Neuron. 86(3):617-631. 2015.
  107. Andoh-Noda T, Akamatsu W, Miyake K, Matsumoto T, Yamaguchi R, Sanosaka T, Okada Y, Kobayashi T, Ohyama M, Nakashima K, Kurosawa H, Kubota T, Okano H. Differentiation of multipotent neural stem cells derived from Rett syndrome patients is biased toward the astrocytic lineage.Mol Brain. 2015;8(1):31.
  108. Hikishima K, Ando K, Komaki Y, Kawai K, Yano R, Inoue T, Itoh T, Yamada M, Momoshima S, Okano HJ, Okano H. Voxel-based morphometry of the marmoset brain: In vivo detection of volume loss in the substantia nigra of the MPTP-treated Parkinson’s disease model.Neuroscience. 2015;300:585-92.
  109. Ishii K, Suzuki N, Mabuchi Y, Ito N, Kikura N, Fukada SI, Okano H, Takeda S, Akazawa C. Muscle Satellite Cell Protein Teneurin-4 Regulates Differentiation during Muscle Regeneration.Stem Cells. 2015;33(10):3017-27.
  110. Iwai H, Shimada H, Nishimura S, Kobayashi Y, Itakura G, Hori K, Hikishima K, Ebise H, Negishi N, Shibata S, Habu S, Toyama Y, Nakamura M, Okano H. Allogeneic Neural Stem/Progenitor Cells Derived From Embryonic Stem Cells Promote Functional Recovery After Transplantation Into Injured Spinal Cord of Nonhuman Primates.Stem Cells Transl Med. 2015;4(7):708-19.
  111. Yu-Ching Lin Z, Hirano T, Shibata S, Seki NM, Kitajima R, Sedohara A, Siomi MC, Sasaki E, Siomi H, Imamura M, Okano H. Gene expression ontogeny of spermatogenesis in the marmoset uncovers primate characteristics during testicular development.Dev Biol. 2015;400(1):43-58.
  112. Yamamoto-Hino M, Muraoka M, Kondo S, Ueda R, Okano H, Goto S. Dynamic regulation of innate immune responses in Drosophila by Senju-mediated glycosylation.Proc Natl Acad Sci U S A. 2015;112(18):5809-14.
  113. Tsuboi D, Kuroda K, Tanaka M, Namba T, Iizuka Y, Taya S, Shinoda T, Hikita T, Muraoka S, Iizuka M, Nimura A, Mizoguchi A, Shiina N, Sokabe M, Okano H, Mikoshiba K, Kaibuchi K. Disrupted-in-schizophrenia 1 regulates transport of ITPR1 mRNA for synaptic plasticity.Nat Neurosci. 2015;18(5):698-707.
  114. Takata N, Yoshida K, Komaki Y, Xu M, Sakai Y, Hikishima K, Mimura M, Okano H, Tanaka KF. Optogenetic Activation of CA1 Pyramidal Neurons at the Dorsal and Ventral Hippocampus Evokes Distinct Brain-Wide Responses Revealed by Mouse fMRI.PLoS One . 2015;10(3):e0121417.
  115. Tokuno H, Watson C, Roberts A, Sasaki E, Okano H. Marmoset Neuroscience.Neurosci Res. 2015;93:1-2.
  116. Kano SI, Yuan M, Cardarelli RA, Maegawa G, Horiuchi Y, Higurashi N, Gaval-Cruz M, Wilson AM, Tristan C, Kondo MA, Chen Y, Koga M, Obie C, Ishizuka K, Seshadri S, Srivastava R, Kato TA, Sedlak TW, Lee Y, Rapoport JL, Hirose S, Okano H, Valle D, O’Donnell P, Sawa A, Kai M. Clinical utility of neuronal cells directly converted from fibroblasts of patients for neuropsychiatric disorders: studies of lysosomal storage diseases and channelopathy.Curr Mol Med. 2015;15(2):138-45.
  117. Nori S, Okada Y, Nishimura S, Sasaki T, Itakura G, Kobayashi Y, Renault-Mihara F, Shimizu A, Koya I, Yoshida R, Kudoh J, Koike M, Uchiyama Y, Ikeda E, Toyama Y, Nakamura M, Okano H. Long-Term Safety Issues of iPSC-Based Cell Therapy in a Spinal Cord Injury Model: Oncogenic Transformation with Epithelial-Mesenchymal Transition.Stem Cell Reports. 2015;4(3):360-73. 2015.
  118. Fujioka M, Okano H, Edge AS. Manipulating cell fate in the cochlea: a feasible therapy for hearing loss.Trends Neurosci. 2015;38(3):139-144.
  119. Hayashi S, Yano M, Igarashi M, Okano HJ, Okano H. Alternative Role of HuD Splicing Variants in Neuronal Differentiation.J Neurosci Res. 2015;93(3):399-409.
  120. Itakura G, Kobayashi Y, Nishimura S, Iwai H, Takano M, Iwanami A, Toyama Y, Okano H, Nakamura M. Controlling Immune Rejection Is a Fail-Safe System against Potential Tumorigenicity after Human iPSC-Derived Neural Stem Cell Transplantation.PLoS One. 2015;10(2):e0116413.
  121. Yamada I, Miyasaka N, Hikishima K, Tokairin Y, Kawano T, Ito E, Kobayashi D, Eishi Y, Okano H. Ultra-high-resolution MR imaging of esophageal carcinoma at ultra-high field strength (7.0 T) ex vivo: Correlation with histopathologic findings.Magn Reson Imaging. 2015;33(4):413-9.
  122. Hikishima K, Ando K, Yano R, Kawai K, Komaki Y, Inoue T, Itoh T, Yamada M, Momoshima S, Okano HJ, Okano H. Parkinson Disease: Diffusion MR Imaging to Detect Nigrostriatal Pathway Loss in a Marmoset Model Treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine.Radiology. 2015;275(2):430-7.
  123. Yamada I, Miyasaka N, Hikishima K, Kato K, Kojima K, Kawano T, Ito E, Kobayashi D, Eishi Y, Okano H. Gastric Carcinoma: Ex Vivo MR Imaging at 7.0 T-Correlation with Histopathologic Findings.Radiology. 2015;275(3):841-8.
  124. Yano M, Ohtsuka T, Okano H. RNA-binding protein research with transcriptome-wide technologies in neural development.Cell Tissue Res. 2015;359(1):135-44.
  125. Fujioka M, Okano H, Ogawa K. Inflammatory and immune responses in the cochlea: potential therapeutic targets for sensorineural hearing loss.Front Pharmacol. 2014;5:287. 2014.
  126. Shibata S, Komaki Y, Seki F, Inouye MO, Nagai T, Okano H. Connectomics: comprehensive approaches for whole-brain mapping.Microscopy(Oxf). 2014;64(1):57-67. 2014.
  127. Tashiro S, Shinozaki M, Mukaino M, Renault-Mihara F, Toyama Y, Liu M, Nakamura M, Okano H. BDNF Induced by Treadmill Training Contributes to the Suppression of Spasticity and Allodynia After Spinal Cord Injury via Upregulation of KCC2.Neurorehabil Neural Repair. 2014;29(7):677-89.
  128. Takemi M, Kondo T, Yoshino-Saito K, Sekiguchi T, Kosugi A, Kasuga S, Okano HJ, Okano H, Ushiba J. Three-dimensional motion analysis of arm-reaching movements in healthy and hemispinalized common marmosets.Behav Brain Res. 2014; 275:259-68. 2014.
  129. Nishimura S, Sasaki T, Shimizu A, Yoshida K, Iwai H, Koya I, Kobayashi Y, Iakura G, Shibata S, Ebise H, Horiuchi K, Kudoh J, Toyama Y, Anderson AJ, Okano H, Nakamura M. Global gene expression analysis following spinal cord injury in non-human primates.Exp Neurol. 2014;261:171-9.
  130. Zhang H, Tan E, Suzuki Y, Hirose Y, Kinoshita S, Okano H, Kudoh J, Shimizu A, Saito K, Watabe S, Asakawa S. Dramatic improvement in genome assembly achieved using doubled-haploid genomes.Sci Rep. 2014;4:6780.
  131. Kuwako K, Nishimoto Y, Kawase S, Okano HJ, Okano H. Cadherin-7 Regulates Mossy Fiber Connectivity in the Cerebellum.Cell Rep. 2014;9(1):311-23.
  132. Maekawa M, Yamada K, Toyoshima M, Ohnishi T, Iwayama Y, Shimamoto C, Toyota T, Nozaki Y, Balan S, Matsuzaki H, Iwata Y, Suzuki K, Miyashita M, Kikuchi M, Kato M, Okada Y, Akamatsu W, Mori N, Owada Y, Itokawa M, Okano H, Yoshikawa T. Utility of Scalp Hair Follicles as a Novel Source of Biomarker Genes for Psychiatric Illnesses.Biol Psychiatry. 2014;78(2):116-25.
  133. Nishikawa R, Hotta R, Shimojima N, Shibata S, Nagoshi N, Nakamura M, Matsuzaki Y, Okano HJ, Kuroda T, Okano H, Morikawa Y. Migration and differentiation of transplanted enteric neural crest-derived cells in murine model of Hirschsprung’s disease.Cytotechnology. 2014;67(4):661-70.
  134. Okano H. Stem cell research and regenerative medicine in 2014: first year of regenerative medicine in Japan.Stem Cells Dev. 2014;23(18):2127-2128. 2014.
  135. Kawase S, Kuwako K, Imai T, Renault-Mihara F, Yaguchi K, Itohara S, Okano H. Rfx Transcription Factors Control Musashi1 Transcription in Mouse Neural Stem/Progenitor Cells.Stem Cells Dev. 2014;23(18):2250-61.
  136. Yamada I, Hikishima K, Miyasaka N, Tokairin Y, Kawano T, Ito E, Kobayashi D, Eishi Y, Okano H, Shibuya H. Diffusion-tensor MRI and tractography of the esophageal wall ex vivo.J Magn Reson Imaging. 2014;40(3):567-76.
  137. Okano H, Mitra P. Brain-mapping projects using the common marmoset.Neurosci Res. 2014;93:3-7.
  138. Matsuzaki Y, Mabuchi Y, Okano H. Leptin Receptor Makes Its Mark on MSCs.Cell Stem Cell. 2014;15(2):112-4. 2014.
  139. Kondo T, Funayama M, Tsukita K, Hotta A, Yasuda A, Nori S, Kaneko S, Nakamura M, Takahashi R, Okano H, Yamanaka S, Inoue H. Focal Transplantation of Human iPSC-Derived Glial-Rich Neural Progenitors Improves Lifespan of ALS Mice.Stem Cell Reports. 2014;3(2):242-9.
  140. Murota Y, Ishizu H, Nakagawa S, Iwasaki YW, Shibata S, Kamatani MK, Saito K, Okano H, Siomi H, Siomi MC. Yb Integrates piRNA Intermediates and Processing Factors into Perinuclear Bodies to Enhance piRISC Assembly.Cell Rep. 2014;8(1):103-13.
  141. Yamada I, Hikishima K, Miyasaka N, Kawano T, Tokairin Y, Ito E, Kobayashi D, Eishi Y, Okano H. Esophageal Carcinoma: Ex Vivo Evaluation with Diffusion-Tensor MR Imaging and Tractography at 7 T.Radiology. 2014;272(1):164-73.
  142. Yoshida T, Ozawa Y, Suzuki K, Yuki K, Ohyama M, Akamatsu W, Matsuzaki Y, Shimmura S, Mitani K, Tsubota K, Okano H. The use of induced pluripotent stem cells to reveal pathogenic gene mutations and explore treatments for retinitis pigmentosa.Mol Brain. 2014;7(1):45.
  143. Kato M, Okanoya K, Koike T, Sasaki E, Okano H, Watanabe S, Iriki A. Human speech- and reading-related genes display partially overlapping expression patterns in the marmoset brain.Brain Lang. 2014; 133:26-38.
  144. Fukuda T, Takeda S, Xu R, Sato T, Bando W, Ochi H, Sunamura S, Fujita K, Shinomiya K, Okano H, Kimura A, Enomoto M, Okawa A, Itoh H.: Sema3A regulates bone mass accrual through sensory innervations.Nature. 2013;497:490-3.
  145. Okano H, Nakamura M, Yoshida K, Okada Y, Tsuji O, Nori S, Ikeda E, Yamanaka S, Miura K.: Steps toward safe cell therapy using induced pluripotent stem cells. Circulation Research. 2013;112:523-533.
  146. Ito D, Okano H, Suzuki N: Accelerating progress in iPS cell research for neurological diseases. Ann. Neurol. 2012;72:167-74.
  147. Nori S, Okada Y, Yasuda A, Tsuji O, Takahashi Y, Kobayashi Y, Fujiyoshi K, Koike M, Uchiyama Y, Ikeda E, Toyama Y, Yamanaka S, Masaya N, Okano H. Grafted human induced pluripotent stem cell-derived neurospheres promotes motor functional recovery after spinal cord injury in mice. Proc.Natl.Acad.Sci.USA. 2011;108:16825-30.
  148. Tsuji O, Miura K, Okada Y, Fujiyoshi K, Nagoshi N, Kitamura K, Kumagai G, Mukaino M, Nishino M, Tomisato S, Higashi H, Ikeda E, Nagai T, Kohda K, Takahashi K, Okita K, Katoh H, Matsuzaki Y, Yuzaki M, Toyama Y, Nakamura M, Yamanaka S and Okano H. Therapeutic effect of the appropriatelly evaluated ‘safe’ iPS cells for spinal cord injury. Proc.Natl.Acad.Sci.USA. 2010;107:12704-9.
  149. Kuwako K, Kakumoto K, Imai T, Igarashi M, Hamakubo T, Sakakibara S, Tessier-Lavigne M, Okano HJ, Okano H. Neural RNA-binding protein Musashi1 controls midline crossing of precerebellar neurons through post-transcriptional regulation of Robo3/Rig-1 expression. Neuron. 2010;67:407-21.
  150. Miura K, Okada Y, Aoi T, Okada A, Takahashi K, Okita K, Nakagawa M, Koyanagi M, Tanabe K, Ohnuki M, Ogawa D, Ikeda E, Okano H, Yamanaka S. Variation in the safety of inducedpluripotent stem cell lines. Nature Biotechnol. 2009;27:743-5.
  151. Sasaki E, Suemizu H, Shimada A, Hanazawa K, Oiwa R, Kamioka M, Sotomaru Y, Hirakawa R, Eto T, Shiozawa S, Maeda T, Ito R, Kito C, Yagihashi C, Kawai K, Miyoshi H, Tanioka Y, Tamaoki N, Habu S, Okano H, Nomura T. Generation of transgenic non-human primates with germ line transmission. Nature. 2009;459:523-7.
  152. Naka H, Nakamura S, Shimazaki T, Okano H. Requirement for COUP-TFI and II in the temporal specification of neural stem cells in central nervous system development. Nature Neurosci. 2008;11:1014-23.
  153. Nagoshi N, Shibata S, Kubota Y, Nakamura M, Nagai Y, Satoh E, Okada Y, Mabchi Y, Katoh H, Okada S, Fukuda K, Suda T, Matsuzaki Y, Toyama Y, Okano H. Ontogeny and Multipotency of Neural Crest-Derived Stem Cells in Bone Marrow, Dorsal Root Ganglia and Whisker Pad of Adult Rodents. Cell Stem Cell. 2008;2:392-403.

A03-2

  1. Koga S, Ono M, Sahara N, Higuchi M, Dickson DW. Fluorescence and autoradiographic evaluation of tau PET ligand PBB3 to a-synuclein pathology.Movement Disorder in press
  2.  Ishigaki S, Fujioka Y, Okada Y, Riku Y, Udagawa T, Honda D, Yokoi S, Endo K, Ikenaka K, Takagi S, Iguchi Y, Sahara N, Takashima A, Okano H, Yoshida M, Warita H, Aoki M, Watanabe H, Okad H, Katsuno M, Sobue G. Altered tau isoform ratio caused by loss of FUS and SFPQ function leads to FTLD-like phenotypes.Cell Reports. 2017 18, 1-14
  3. Ono M, Sahara N, Kumata K, Ji B, Ni R, Dickson DW, Trojanowski JQ, Lee VM-Y, Yoshida M, Hozumi I, Yoshiyama Y, Nordberg A, Suhara T, Zhang M-R, Higuchi M. Distinct binding of two PET ligands, PBB3 and AV-1451, to tau fibril strains in Alzheimer’s disease and related neurodegenerative tauopathy disorders..Brain.. 2017-03
  4. Imamura K, Sahara N, Kanaan NM, Tsukita K, Kondo T, Ohsawa Y, Sunada Y, Kawakami K, Hotta A, Yawata S, Watanabe D, Hasegawa M, Trojanowski JQ, Lee VM, Suhara T, Higuchi M, Inoue H. Calcium dysregulation contributes to neurdegeneration in FTLD patient iPSC-derived neurons.Scientific Report. 2016 Oct 10; 6:34904
  5. Huguchi M, Ji B, Sahara N, and Suhara T. In vivo imaging of inflammation in Alzheimer’s disease.Clinical and Experimental Neuroimmunology2016 7(2): 139-144
  6. Higuchi H, Ji B, Maeda J, Sahara N, Suhara T. In vivo imaging of neuroinflammation in Alzheimer’s disease.Clinical and Experimental Neuroimmunology in press. 2016
  7. Dulal HP, Nagae M, Ikeda A, Morita-Matsumoto K, Adachi Y, Ohno N, Yamaguchi Y. Enhancement of solubility and yield of a β-glucan receptor Dectin-1 C-type lectin-like domain in Escherichia coli with a solubility-enhancement tag.Protein Expr. Purif. 2016;123, 97-104.
  8. Nagae M, Ikeda A, Hanashima S, Kojima T, Matsumoto N, Yamamoto K, Yamaguchi Y. Crystal structure of human dendritic cell inhibitory receptor (DCIR) C-type lectin domain reveals the binding mode with N-glycan.FEBS Lett. 2016;590(8), 1280-8.
  9. Aoyagi T, Ohira S, Fuse S, Uzawa J, Yamaguchi Y, Tanaka H. The α-glycosidation of partially unprotected N-acetyl and N-glycolyl sialyl donors in the absence of a nitrile solvent effect.Chem. Eur J. 2016;22(20), 6968-73.
  10. Yoshihara A, Fukatsu M, Hoshi K, Ito H, Nollet K, Yamaguchi Y, Ishii R, Tokuda T, Miyajima M, Arai H, Kato T, Furukawa K, Arai H, Kikuchi A, Takeda A, Ugawa Y, Hashimoto Y*. Subgroup differences in “brain-type” transferrin and alpha-synuclein in Parkinson’s disease and multiple system atrophy.J. Biochem. 2016. [Epub ahead of print]
  11. Nagae M, Kanagawa M, Morita-Matsumoto K, Hanashima S, Kizuka Y, Taniguchi N, Yamaguchi Y. Atomic visualization of a flipped-back conformation of bisected glycans bound to specific lectins.Sci. Rep. 2016;6, 22973.
  12. Kanagawa M, Kobayashi K, Tajiri M, Manya H, Kuga A, Yamaguchi Y, Akasaka-Manya K, Furukawa J, Mizuno M, Kawakami H, Shinohara Y, Wada Y, Endo T, Toda T. Identification of a post-translational modification with ribitol-phosphate and its defect in muscular dystrophy.Cell Rep. 2016;14(9), 2209-23.
  13. Carvalho S, Catarino TA, Dias AM, Kato M, Almeida A, Hessling B, Figueiredo J, Gartner F, Sanches JM, Ruppert T, Miyoshi E., Pierce M, Carneiro F, Kolarich D, Seruca R, Yamaguchi Y, Taniguchi N, Pinho SS. Preventing E-cadherin aberrant N-glycosylation at Asn-554 improves its critical function in gastric cancer.Oncogene. 2016;35(13), 1619-31.
  14. Kimura Y, Endo H, Ichise M, Shimada H, Seki C, Ikoma Y, Shinotoh H, Yamada M, Higuchi M, Zhang M-R, Suhara T. A new method to quantify tau pathologies with (11)C-PBB3 PET using reference tissue voxels extracted from brain cortical gray matter.EJNMMI research. 2016;6(1), 24, DOI:10.1186/s13550-016-0182-y.
  15. Kimura Y, Seki C, Ikoma Y, Ichise M, Kawamura K, Takahata K, Moriguchi S, Nagashima T, Ishii T, Kitamura S, Niwa F, Endo H, Yamada M, Higuchi M, Zhang M-R, Suhara T. [(11)C]TASP457, a novel PET ligand for histamine H3 receptors in human brain.European Journal of Nuclear Medicine and Molecular Imaging. 2016;DOI:10.1007/s00259-016-3332-6.
  16. Koga K, Maeda J, Tokunaga M, Hanyu M, Kawamura K, Ohmichi M, Nakamura T, Nagai Y, Seki C, Kimura Y, Minamimoto T, Zhang M-R, Fukumura T, Suhara T, Higuchi M. Development of TASP0410457 (TASP457), a novel dihydroquinolinone derivative as a PET radioligand for central histamine H3 receptors.EJNMMI Research. 2016;6(1), 11, DOI:10.1186/s13550-016-0170-2.
  17. Moraga A, Gómez-Vallejo V, Isabel Cuartero M, Szczupak B, San Sebastián E, Markuerkiaga I, Pradillo J.M., Higuchi M, Llop J, Moro M. Á., Martín A, Lizasoain I. Imaging the role of TLR4 on cell proliferation and inflammation after cerebral ischemia by PET.Journal of Cerebral Blood Flow and Metabolism. 2016;DOI:10. 1177/0271678X15627657Goda.
  18. Goda N, Yokoi I, Tachibana A, Minamimoto T, Komatsu H. Crossmodal association of visual and haptic material properties of objects in the monkey ventratl visual cortex.Curr. Biol. 2016;26(7): 928-34.
  19. McCairn KW, Nagai Y, Hori Y, Kikuchi E, Ninomiya T, Suhara T, Lee J-Y, Iriki A, Minamimoto T, Takada M, Isoda M, Matsumoto M. A primary role for nucleus accumbens and related limbic network in vocal ticsNeuron. 2016;89(2), 300 – 307.
  20. Eldridge MAG, Lerchner W, Saunders RC, Kaneko H, Krausz KW, Gonzalez FJ, Ji B, Higuchi M, Minamimoto T, Richmond BJ. Chemogenetic disconnection of monkey orbitofrontal and rhinal cortex reversibly disrupts reward value.Nature Neuroscience. 2016;19(1), 37 – 39, DOI:doi:10.1038/nn. 4192.
  21. Carvalho S, Catarino TA, Dias AM, Kato M, Almeida A, Hessling B, Figueiredo J, Gartner F, Sanches JM, Ruppert T, Miyoshi E., Pierce M, Carneiro F, Kolarich D, Seruca R, Yamaguchi Y, Taniguchi N, Pinho SS. Preventing E-cadherin aberrant N-glycosylation at Asn-554 improves its critical function in gastric cancer.Oncogene. 2016;35(13), 1619-31.
  22. Shimojo M, Higuchi M, Suhara T, Sahara N. Imaging Multimodalities for Dissecting Alzheimer’s Disease: Advanced Technologies of Positron Emission Tomography and Fluorescence Imaging.Frontiers in Neuroscience. 2015;9.
  23. Kimura Y, Ichise M, Ito H, Shimada H, Ikoma Y, Seki C, Takano H, Kitamura S, Shinotoh H, Kawamura K, Zhang M-R, Sahara N, Suhara T, Higuchi M. PET Quantification of Tau Pathology in Human Brain with 11C-PBB3.Journal of Nuclear Medicine. 2015;56(9), 1359 – 1365.
  24. Yagi H, Zhang Y, Yagi-Utsumi M, Yamaguchi T, Iida S, Yamaguchi Y, Kato K. Backbone ¹H, ¹³C, and ¹⁵N resonance assignments of the Fc fragment of human immunoglobulin G glycoprotein.Biomol. NMR Assign. 2015;9(2), 257-60.
  25. Nagae M, Yamaguchi Y. Sugar recognition and protein–protein interaction of mammalian lectins conferring diverse functions.Curr. Opin. Struct. Biol. 2015;34, 108-115.
  26. Ohira S, Yamaguchi Y, Takahashi T, Tanaka H. The chemoselective O-glycosylation of alcohols in the presence of a phosphate diester and its application to the synthesis of oligomannosylated phosphatidyl inositols.Tetrahedron. 2015;71(37), 6602-11.
  27. Kawatani M, Fukushima Y, Kondoh Y, Honda K, Sekine T, Yamaguchi Y, Taniguchi N, Osada H. Identification of matrix metalloproteinase inhibitors by chemical arrays. Biosci. Biotechnol.Biochem. 2015;79(10), 1597-602.
  28. Hanashima S, Gotze S, Liu Y, Ikeda A, Kojima-Aikawa K, Taniguchi N, Silva DV, Feizi T, Seeberger PH, Yamaguchi Y. Defining the interaction of human soluble lectin ZG16p and mycobacterial phosphatidylinositol mannosides.ChemBiocChem. 2015;16(10), 1502-11.
  29. Matsumoto Y, Saito T, Hoshi K, Ito H, Kariya Y, Nagae M, Yamaguchi Y, Hagiwara Y, Kinoshita N, Wada I, Saito K, Honda T, Hashimoto Y. In situ visualization of a glycoform of transferrin: localization of α2,6-sialylated transferrin in the liver.J. Biochem. 2015;157(4), 211-6.
  30. Hasegawa Y, Takahashi M, Ariki S, Asakawa D, Tajiri M, Wada Y, Yamaguchi Y, Nishitani C, Takamiya R, Saito A, Uehara Y, Hashimoto J, Kurimura Y, Takahashi H, Kuroki Y. Surfactant protein D suppresses lung cancer progression by downregulation of epidermal growth factor signaling.Oncogene. 2015;34(7), 838-45.
  31. Garénaux E, Kanagawa M, Tsuchiyama T, Hori K, Kanazawa T, Goshima A, Chiba M, Yasue H, Ikeda A, Yamaguchi Y, Sato C, Kitajima K. Discovery, Primary and Crystal Structures, and Capacitation-Related Properties of a Prostate-Derived Heparin-Binding Protein WGA16 from Boar Sperm.J. Biol. Chem . 2015;290(9), 5484-501.
  32. Sato S, Takeuchi R, Yagi-Utsumi M, Yamaguchi T, Yamaguchi Y, Kato K, Fujita M. A Self-Assembled, π-Stacked Complex as a Finely-Tunable Magnetic Aligner for Biomolecular NMR Applications.Chem. Commun. 2015;51, 2540-3.
  33. Kizuka Y, Kitazume S, Fujinawa R, Saito T, Iwata N, Saido TC, Nakano M, Yamaguchi Y, Hashimoto Y, Staufenbiel M, Hatsuta H, Murayama S, Manya H, Endo T, Taniguchi N. An aberrant sugar modification of BACE1 blocks its lysosomal targeting in Alzheimer’s disease.EMBO Mol Med. 2015;7(2), 175-89.
  34. Takuwa H, Maeda J, Ikoma Y, Tokunaga M, Wakizaka H, Uchida S, Kanno I, Taniguchi J, Ito H, Higuchi M. [(11) C]Raclopride binding in the striatum of minimally restrained and free-walking awake mice in a positron emission tomography study.Synapse(New York, N.Y.). 2015;69(12), 600 – 606, DOI:10.1002/syn.21864
  35. Xie L, Maeda J, Kumata K, Yui J, Zhang Y, Hatori A, Nengaki N, Wakizaka H, Fujinaga M, Yamasaki T, Shimoda Y, Higuchi M, Suhara T, Wang F, Zhang M-R. Development of 1-N-(11)C-Methyl-l- and -d-Tryptophan for pharmacokinetic imaging of the immune checkpoint inhibitor 1-Methyl-Tryptophan.Scientific Reports. 2015;5, 16417, DOI:doi:10.1038/srep16417
  36. Oi N, Tokunaga M, Suzuki M, Nagai Y, Nakatani Y, Yamamoto N, Maeda J, Minamimoto T, Zhang M-R, Suhara T, Higuchi M. Development of Novel PET Probes for Central 2-Amino-3-(3-hydroxy-5-methyl-4-isoxazolyl)propionic acid (AMPA) Receptors.Journal of Medicinal Chemistry Manuscript. 2015;58(21), 8444 – 8462, DOI:10.1021/acs.jmedchem.5b00712
  37. Hashimoto H, Kawamura K, Takei M, Igarashi N, Fujishiro T, Shiomi S, Watanabe R, Muto M, Furutsuka K, Ito T, Yamasaki T, Yui J, Nemoto K, Kimura Y, Higuchi M, Zhang M-R. Identification of a major radiometabolite of [11C]PBB3.Nuclear Medicine and Biology。2015;42(12), 905 – 910, DOI:doi:10.1016/j.nucmedbio.2015.08.006
  38. Ji B, Chen C-J, Bando K, Ashino H, Shiraishi H, Sano H, Kasahara H, Minamizawa T, Yamada K, Ono M, Zhang M-R, Seki C, Farde L, Suhara T, Higuchi M. Distinct Binding of Amyloid Imag.ing Ligands to Unique Amyloid-β Deposited in the Presubiculum of Alzheimer’s Disease.Journal of Neurochemitry.2015-08
  39. Shimada H, Shinotoh H, Ota T, Sato K, Yamada M, Fukushi K, Irie T, Zhang M-R, Higuchi M, Kuwabara S, Suhara T. Dementia with Lewy bodies can be well-differentiated from Alzheimer’s disease by measurement of brain acetylcholinesterase activity – A [11C]MP4A PET study.International Journal of Geriatric Psychiatry. 2015;30(11), 1105 – 1113, DOI:10.1002/gps.4338
  40. Tiwari A, Ji B, Yui J, Fujinaga M, Yamasaki T, Xie L, Luo R, Shimoda Y, Kumata K, Zhang Y, Hatori A, Maeda J, Higuchi M, Wang F, Zhang M-R. [(18)F]FEBMP: Positron Emission Tomography Imaging of TSPO in a Model of Neuroinflammation in Rats, and in vitro Autoradiograms of the Human Brain.Theranostics. 2015;5(9), 961 – 969.
  41. Martin A, Szcaupak B, Gomez-Vallejo V, Domercq M, Cano A, Padro D, Munoz C, Higuchi M, Matute C, Llop J. In Vivo PET Imaging of the α4β2 Nicotinic Acetylcholine Receptor As a Marker for Brain Inflammation after Cerebral Ischemia.Journal of Neuroscience. 2015;35(15), 5998 – 6009, DOI:10.1523/JNEUROSCI. 2015;3670-14.
  42. Chen C-J, Bando K, Ashino H, Taguchi K, Shiraishi H, Shima K, Fujimoto O, Kitamura C, Matsushima S, Uchida K, Nakahara Y, Kasahara H, Minamizawa T, Jiang C, Zhang M-R, Ono M, Tokunaga M, Suhara T, Higuchi M, Yamada K, Ji B. In Vivo SPECT Imaging of Amyloid-β Deposition with Radioiodinated Imidazo[1,2-a]pyridine Derivative DRM106 in Mouse Model of Alzheimer’s Disease.JNM/JNMT. 2015;56(1), 120 – 126, DOI:10.2967/jnumed. 2015;114.146944
  43. Tateno A, Sakayori T, Higuchi M, Suhara T, Ishihara K, Kumita S, Suzuki H, Okubo Y. Amyloid imaging with [(18) F]florbetapir in geriatric depression: early-onset versus late-onset.International journal of geriatric psychiatry. 2015; 30(7), 720 – 728, DOI:10.1002/gps.4215
  44. Tateno A, Sakayori T, Kawashima Y, Higuchi M, Suhara T, Mizumura S, Mintun MA, Skovronsky DM, Honjo K, Ishihara K, Kumita S, Suzuki H, Okubo Y. Comparison of imaging biomarkers for Alzheimer’s disease: amyloid imaging with [(18) F]florbetapir positron emission tomography and magnetic resonance imaging voxel-based analysis for entorhinal cortex atrophy.International journal of geriatric psychiatry. 2015;30(5), 505 – 513, DOI:10.1002/gps.417Endo
  45. T, Saijo T, Haneda E, Maeda J, Tokunaga M, Zhang M-R, Kannami A, Asai H, Suzuki M, Suhara T, Higuchi M. Quantification of central substance P receptor occupancy by aprepitant using small animal positron emission tomography.The international journal of neuropsychopharmacology. 2015;18(2), 1 – 10.
  46. Matsumoto KI, Yamasaki T, Nakamura M, Ishikawa J, Ueno M, Nakanishi I, Sekita A, Ozawa Y, Kamada T, Aoki I, Yamada KI. Brain contrasting ability of blood-brain-barrier-permeable nitroxyl contrast agents for magnetic resonance redox imaging.Magn Reson Med. 2015
  47. Bakalova R, Georgieva E, Ivanova D, Zhelev Z, Aoki I, Saga T. Magnetic resonance imaging of mitochondrial dysfunction and metabolic activity, accompanied by overproduction of superoxide.ACS Chem Neurosci. 2015;6(12):1922-9.
  48. Okada M, Kikuchi T, Okamura T, Ikoma Y, Tsuji AB, Wakizaka H, Kamakura T, Aoki I, Zhang MR, Kato K. In-vivo imaging of blood-brain barrier permeability using positron emission tomography with 2-amino-[3-11C]isobutyric acid.Nucl Med Commun. 2015;36(12):1239-48.
  49. Matsumoto K, Nakamura M, Ueno M, Nakanishi I, Shibata S, Sekita A, Saga T, Kamada T, Yamada K, Aoki I. Matsumoto K, Brain Contrasting Ability of Blood-Brain-Barrier-Permeable Nitroxyl Contrast Agents for Magnetic Resonance RedOx Imaging.Magn Reson Med. 2015; doi: 10.1002/mrm.25918. [Epub ahead of print] PubMed PMID: 26414669.
  50. Aoki I, Yoneyama M, Hirose J, Minemoto Y, Koyama T, Kokuryo D, Bakalova R, Murayama S, Saga T, Aoshima S, Ishizaka Y, Kono K. Thermoactivatable polymer-grafted liposomes for low-invasive image-guided chemotherapy.Transl Res. 2015;166(6):660-673.e1.
  51. Sawada K, Horiuchi-Hirose M, Saito S, Aoki I. Male prevalent enhancement of leftward asymmetric development of the cerebellar cortex in ferrets (Mustela putorius).Laterality. 2015;20(6):723-37.
  52. Sawada K, Horiuchi-Hirose M, Saito S, Aoki I. Sexual dimorphism of sulcal morphology of the ferret cerebrum revealed by MRI-based sulcal surface morphometry.Front Neuroanat. 2015; 6;9:55.
  53. Gündüz S, Nitta N, Vibhute S, Shibata S, Mayer ME, Logothetis NK, Aoki I, Angelovski G. Dendrimeric calcium-responsive MRI contrast agents with slow in vivo diffusion.Chem Commun (Camb). 2015;51(14):2782-5.
  54. Sahara N, Murayama M, Higuchi M, Suhara T, Takashima A. Biochemical distribution of tau protein in synaptosomal fraction of transgenic mice expressing human P301L tau.Frontiers in Neurology. 2014;11;5:26:1.
  55. Bailey RM, Howard J, Knight J, Sahara N, Dickson DW, and Lewis J. Effects of the C57BL/6 strain background on tauopathy progression in the tTg4510 mouse model.Mol Neurodegener. 2014;15;9(1):8.
  56. Ren Y, Lin W-L, Sanchez L, Ceballos C, Polydoro M, Spires-Jones TL, Hyman BT, Dickson DW, Sahara N. Endogenous tau aggregates in oligodendrocytes of rTg4510 mice induced by human P301L tau.J. Alzheimer’s Disease. 2014;38(3):589-600.
  57. Sahara N and Avila J. “Tau oligomers”, what we know and what we don’t know.Frontiers in Neurology. 2014;13;5:1.
  58. Satoh T, Sumiyoshi A, Yagi-Utsumi M, Sakata E, Sasakawa H, Kurimoto E, Yamaguchi Y, Li W, Joazerio CA P, Hirokawa T, Kato K. Mode of substrate recognition by the Josephin domain of ataxin-3, which has an endo-type deubiquitinase activity.FEBS Lett. 2014;588, 4422-30.
  59. Nagae M, Morita-Matsumoto K, Kato M, Kaneko MK, Kato Y, Yamaguchi Y. A platform of C-type lectin-like receptor CLEC-2 for binding O-glycosylated podoplanin and nonglycosylated rhodocytin.Structure. 2014;22(12), 1711-21.
  60. Sudo M, Yamaguchi Y, Späth PJ, Matsumoto-Morita K, Ong BK, Shahrizaila N, Yuki N. Different IVIG glycoforms affect in vitro inhibition of anti-ganglioside antibody-mediated complement deposition.PLoS ONE. 2014;9(9), e107772.
  61. Kawasaki N, Okumoto T, Yamaguchi Y, Takahashi N, Fridman WH, Sautès-Fridman C, Yagi H, Kato K. Site-specific classification of N-linked oligosaccharides of the extracellular regions of Fcγ receptor IIIb expressed in baby hamster kidney cells.J. Glycomics Lipidmics. 2014;4(2), 1-5.
  62. Hanashima S, Korekane H, Taniguchi N, Yamaguchi Y. Synthesis of N-glycan units for assessment of substrate structural requirements of N-acetylglucosaminyltransferase III.Bioorg. Med. Chem. Lett. 2014;24(18), 4533-7.
  63. Pradipta AR, Tsutsui A, Ogura A, Hanashima S, Yamaguchi Y, Kurbangalieva A, Tanaka K. Microfluidic mixing of polyamine with acrolein enables the detection of the [4+4] polymerization of intermediary unsaturated imines: The properties of a cytotoxic 1,5-diazacyclooctane hydrogel.SYNLETT and SYNTHESIS. 2014;25(17), 2442-46.
  64. Cho J, Sawaki K, Hanashima S, Yamaguchi Y, Shiro M, Saigo K, Ishida Y. Stabilization of β-peptide helices by direct attachment of trifluoromethyl groups to peptide backbones.Chem Commun. 2014;50(69), 9855-58.
  65. Kitazume S, Imamaki R, Kurimoto A, Ogawa K, Kato M, Yamaguchi Y, Tanaka K, Ishida H, Ando H, Kiso M, Hashii N, Kawasaki N, Taniguchi N. Interaction of platelet endothelial cell adhesion molecule (PECAM) with α2,6-sialylated glycan regulates its cell surface residency and anti-apoptotic role.J. Biol. Chem. 2014; 289(40), 27604-13.
  66. Kariya Y, Kanno M, Matsumoto-Morita K, Konno M, Yamaguchi Y, Hashimoto Y. Osteopontin O-glycosylation contributes to its phosphorylation and cell adhesion properties.Biochem. J. 2014;463(1), 93-102.
  67. Theiler R, Fujita M, Nagae M, Yamaguchi Y, Maeda Y, Kinoshita T. The alpha helical region in p24γ2 subunit of p24 cargo receptor is pivotal for the recognition and transport of glycosylphosphatidylinositol-anchored proteins.J. Biol. Chem. 2014;289(24), 16835-43.
  68. Tsutsui A, Imamaki R, Kitazume S, Hanashima S, Yamaguchi Y, Kaneda M, Oishi S, Fujii N, Kurbangalieva A, Taniguchi N, and Tanaka K. Polyamine modification by acrolein exclusively produces 1,5-diazacyclooctanes: A previously unrecognized mechanism for acrolein-mediated oxidative stress.Org. Biomol. Chem. 2014; 12(28), 5151-7.
  69. Kanagawa M, Liu Y, Hanashima S, Ikeda A, Chai W, Nakano Y, Kojima-Aikawa K, Feizi T, Yamaguchi Y. Structural basis for multiple sugar recognition of Jacalin-related human ZG16p lectin.J. Biol. Chem. 2014;289(24), 16954-65.
  70. Nagae M, Morita-Matsumoto K, Arai S, Wada I, Matsumoto Y, Saito K, Hashimoto Y, Yamaguchi Y. Structural change of N-glycan exposes hydrophobic surface of human transferrin.Glycobiology. 2014;24(8), 693-702.
  71. Mochizuki S, Morishita H, Adachi Y, Yamaguchi Y, Sakurai K. Binding assay between murine Dectin-1 and β-glucan/DNA complex with quartz-crystal microbalance.Carbohydr. 2014;Res., 391, 1-8.
  72. Hanashima S, Yamaguchi Y. Indirect detection of hydroxy proton exchange through deuterium-induced 13C-NMR isotope shifts. Glycoscience:Biology and Medicine. 2014;Volume 1, Chapter 6, 129-135.
  73. Hoshi K, Matsumoto Y, Saito T, Ito H, Kariya Y, Yamaguchi Y, Furukawa K, Arai H, Miyajima M, Arai H, Narimatsu H, Saito K, Honda T, Hashimoto Y. A Glycan Marker for Idiopathic Normal Pressure Hydrocephalus. Glycoscience:Biology and Medicine, 4, 2014.
  74. Yamaguchi Y, Yamaguchi T, Kato K. Structural Analysis of oligosaccharides and glycoconjugates using NMR. Adv.Neurobiol. 2014;9, 165-83.
  75. Yamamoto S, Subedi GP, Hanashima S, Satoh T, Otaka M, Wakui H, Sawada K, Yokota S, Yamaguchi Y, Kubota H, Itoh H. ATPase activity and ATP-dependent conformational change in the co-chaperone HSP70/HSP90-organizing Protein (HOP).J. Biol. Chem. 2014;289(14), 9880-6.
  76. Kurimoto A, Kitazume S, Kizuka Y, Nakajima K, Oka R, Fujinawa R, Korekane H, Yamaguchi Y, Wada Y, Taniguchi N . The absence of core fucose up-regulates GnT-III and Wnt target genes: a possible mechanism for an adaptive response in terms of glycan function.J. Biol. Chem. 2014;289(17), 11704-14.
  77. Nagae M, Ikeda A, Kitago Y, Matsumoto N, Yamamoto K, Yamaguchi Y. Crystal structures of carbohydrate recognition domain of Blood Dendritic Cell Antigen-2 (BDCA2) reveal a common domain-swapped dimer.Proteins. 2014;82(7), 1512-8.
  78. Hanashima S, Ikeda A, Tanaka H, Adachi Y, Ohno N, Takahashi T, Yamaguchi Y. NMR study of short β(1,3)-glucans provides insights into the structure and interaction with Dectin-1.Glycoconj. J. 2014;31(3), 199-207.
  79. Tóth M, Häggkvist J, Varrone A, Finnema SJ, Doorduin J, Tokunaga M, Higuchi M, Gulyás B, Halldin C. ABC transporter dependent brain uptake of the 5-HT1B receptor radioligand [11C]AZ10419369.EJNMMI Research. 2014;4(1), 64, 2014-11, DOI:10.1186/s13550-014-0064-0
  80. Chen C-J, Bando K, Ashino H, Taguchi K, Shiraishi H, Shima K, Fujimoto O, Kitamura C, Morimoto Y, Kasahara H, Minamizawa T, Jiang C, Zhang M-R, Suhara T, Higuchi M, Yamada K, Ji B. Biological evaluation of the radioiodinated imidazo[1,2-a]pyridine derivative DRK092 for amyloid-β imaging in mouse model of Alzheimer’s disease.Neuroscience letters. 2014;581, 103-108,DOI:10.1016/
    j.neulet.2014.08.036
  81. Chen C-J, Bando K, Ashino H, Taguchi K, Shiraishi H, Fujimoto O, Kitamura C, Matsushima S, Fujinaga M, Zhang M-R, Kasahara H, Minamizawa T, Jiang C, Ono M, Higuchi M, Suhara T, Yamada K, Ji B. Synthesis and biological evaluation of novel radioiodinated imidazopyridine derivatives for amyloid-β imaging in Alzheimer’s disease.Bioorganic & Medicinal Chemistry. 2014;22(15), 4189 – 4197, DOI:10.1016/j.bmc.2014.05.043
  82. Seki C, Oh-Nishi A, Nagai Y, Minamimoto T, Obayashi S, Higuchi M, Takei M, Furutsuka K, Ito T, Zhang M-R, Ito H, Ito M, Ito S, Kusuhara H, Sugiyama Y, Suhara T. Evaluation of [(11)C]oseltamivir uptake into the brain during immune activation by systemic polyinosine-polycytidylic acid injection: a quantitative PET study using juvenile monkey models of viral infection.EJNMMI research. 2014;24(4), DOI:doi: 10.1186/s13550-014-0024-8. eCollection 2014.
  83. Hashimoto H, Kawamura K, Igarashi N, Takei M, Fujishiro T, Aihara Y, Shiomi S, Muto M, Ito T, Furutsuka K, Yamasaki T, Yui J, Xie L, Ono M, Hatori A, Nemoto K, Suhara T, Higuchi M, Zhang M-R. Radiosynthesis, Photoisomerization, Biodistribution, and Metabolite Analysis of 11C-PBB3 as a Clinically Useful PET Probe for Imaging of Tau Pathology.Journal of nuclear medicine. 2014;55(9), 1532 – 1538, DOI:10.2967/jnumed.114.139550
  84. Ito H, Shimada H, Shinotoh H, Takano H, Sasaki T, Nogami T, Suzuki M, Nagashima T, Takahata K, Seki C, Kodaka F, Eguchi Y, Fujiwara H, Kimura Y, Hirano S, Ikoma Y, Higuchi M, Kawamura K, Fukumura T, Böö EL, Farde L, Suhara T. Quantitative Analysis of Amyloid Deposition in Alzheimer Disease Using PET and the Radiotracer 11C-AZD2184.Journal of nuclear medicine.2014;55(6), 932 – 938, DOI:10.2967/jnumed.113.133793
  85. Kato Y, Gokan H, Oh-Nishi A, Suhara T, Watanabe S, Minamimoto T . Vocalizations associated with anxiety and fear in the common marmoset (Callithrix jacchus).Behavioural brain research. 2014;275, 43 – 52.
  86. Minamimoto T, Hori Y, Yamanaka K, Kimura M. Neural signal for counteracting pre-action bias in the centromedian thalamic nucleus. Front. Syst.Neurosci. 2014; 28;8:3.
  87. Tajima Y, Takuwa H, Kokuryo D, Kawaguchi H, Seki C, Masamoto K, Ikoma Y, Taniguchi J, Aoki I, Tomita Y, Suzuki N, Kanno I, Saeki N, Ito H. Changes in cortical microvasculature during misery perfusion measured by two-photon laser scanning microscopy.J Cereb Blood Flow Metab. 2014;34(8):1363-72.
  88. Kuroiwa D, Obata T, Kawaguchi H, Autio J, Hirano M, Aoki I, Kanno I, Kershaw J. Signal contributions to heavily diffusion-weighted functional magnetic resonance imaging investigated with multi-SE-EPI acquisitions.Neuroimage. 2014;98:258-65.
  89. Sasaki N, Jo J, Aoki I, Sato K. Magnetic resonance imaging of a microvascular-interstitium model on a microfluidic device.Anal Biochem. 2014;458:72-4.
  90. Ward SM, Himmelstein DS, Ren Y, Fu Y, Yu X-W, Roberts K, Binder LI, Sahara N. TOC1:A valuable tool in assessing disease progression in the rTg4510 mouse model of tauopathy. Neurobiol Dis. 2014;67:37-48.
  91. Sahara N Ren Y, Ward S, Binder L.I., Suhara T, Higuchi M. Tau oligomers as potential targets for early diagnosis of tauopathy. J Alzheimers Dis. 2014;40:S91-6.
  92. Sahara N, Perez PD, Lin W-L, Dickson DW, Ren Y, Zeng H, Lewis J, Febo M.  Age-related decline on white matter integrity in a mouse model of tauopathy: an in vivo diffusion tensor magnetic resonance imaging study. Neurobiol Aging. 2014;35:1364-74.
  93. Maruyama M, Shimada H, Suhara T, Shinoyoh H, Ji B, Maeda J, Zhang MR, Trojanowski JQ, Lee VMY, Ono M, Masamoto K, Takano H, Sahara N, Iwata N, Okamura N, Furumoto S, Kudo Y, Chang Q, Saido TC, Takashima A, Lewis J, Jang MK, Aoki I, Ito H, Higuchi M. Imaging of tau pathology in a tauopathy mouse model and in Alzheimer patients compared to normal control. Neuron. 2013;79:1094-108.
  94. Perez PD, Hall G, Kimura T, Ren Y, Bailey RM, Lewis J, Febo M and Sahara N. ln Vivo Functional Brain Mapping In A Conditional Mouse Model Of Human Tauopathy (tauP301L) Reveals Reduced Neural Activity in Memory Formation Structures. Mol Neurodegener. 2013;8:9.
  95. Sahara N, DeTure M, Ren Y, Ebrahim A-S, Kang D, Knight J, Volbracht C, Pedersen JT, Dickson DW, Yen S-H and Lewis J. Characteristics of TBS-extractable hyperphosphorylated tau species: Aggregation intermediates in rTg4510 mouse brain. J Alzheimers Dis. 2013;33:249-63.
  96. De Calignon A, Polydoro M, Suarez-Calvet M, William C, Adamowicz DH, Kopeikina KJ, Pitstick R, Sahara N, Ashe KH, Carlson GA, Spires-Jones TL, Hyman BT. Propagation of tau pathology in a model of early Alzheimer’s disease. Neuron. 2012;73:685-97
  97. Sahara N, Maeda S, Murayama M, Suzuki T, Dohmae N, Yen SH, Takashima A.  Assembly of two distinct dimers and higher-order oligomers from full-length tau. Eur J Neurosci. 2007;25:3020-29.
  98. Sahara N, Murayama M, Mizoroki T, Urushitani M, Imai Y, Takahashi R, Murata S, Tanaka K, Takashima A.  In vivo evidence of CHIP up-regulation attenuating tau aggregation. J Neurochem. 2005;94:1254-63.
  99. Lewis J, Dickson DW, Lin WL, Chisholm L, Corral A, Jones G, Yen SH, Sahara N, Skipper L, Yager D, Eckman C, Hardy J, Hutton M, McGowan E.  Enhanced neurofibrillary degeneration in transgenic mice expressing mutant tau and APP. Science. 2001;293:1487-91.

A03-公募班員

  1. H. Uchiyama, K. Uehara, T. Nagashima, A. Nakata, K. Sato, Y. Mihara, K. Komatsu, J. Takanari, S. Shimizu, K. Wakame. Global Liver Gene Expression Analysis on a Murine Metabolic Syndrome Model Treated by Low-molecular-weight Lychee Fruit Polyphenol.Anticancer Research36: 3705-3713, 2016
  2. T. Yoshida, M. Tsujioka, S. Honda, S. Shimizu Autophagy suppresses cell migration by degrading GEF-H1, a RhoA GEF. OncoTarget 7:34420-9, 2016
  3. Y. Nasu, A. Benke, S. Arakawa, G. Yoshida, G. Kawamura, S. Manley, S. Shimizu, T. Ozawa. In Situ Characterization of Bak Clusters Responsible for Cell Death Using Single Molecule Localization Microscopy.Scientific Reports6, Article number: 27505, 2016
  4. H. Yamaguchi, S. Arakawa, T. Kanaseki, T. Miyatsuka, Y. Fujitani, H. Watada, Y. Tsujimoto, S. Shimizu. Golgi membrane-associated degradation pathway in yeast and mammals.EMBO J35:1991-2007, 2016
  5. A. Konishi, T. Izumi, S. Shimizu. TRF2 Interacts with Core Histones to Stabilize Chromosome Ends.J. Biol. Chem. 291(39): 20798-810, 2016
  6. S. Torii, T. Yoshida, S. Arakawa, S. Honda, A. Nakanishi, S. Shimizu. Identification of PPM1D as an essential Ulk1 phosphatase for genotoxic stress-induced autophagy.EMBO R11:1552-1564, 2016
  7. Y. Watanabe, S. Honda, A. Konishi, S. Arakawa, M. Murohashi, H. Yamaguchi, S. Torii, M. Tanabe, S. Tanaka, E. Warabi. S. Shimizu. Autophagy controls centrosome number by degrading Cep63.Nature Commun7:13508, 2016
  8. T. Kozaki, J. Komano, D. Kanbayashi, M. Takahama, T. Misawa, T. Satoh, O. Takeuchi, T. Kawai, S. Shimizu, Y. Matsuura, S. Akira, T. Saitoh. Mitochondrial damage elicits a TCDD-inducible poly (ADP-ribose) polymerase-mediated antiviral response.PNAS in press.
  9. Hatate J, Miwa K, Matsumoto M, Sasaki T, Yagita Y, Sakaguchi M, Kitagawa K, Mochizuki H. Association between cerebral small vessel diseases and mild parkinsonian signs in the elderly with vascular risk A57:I66factors.Parkinsonism Relat Disord. 2016 May; 26:29-34.
  10. Beck G, Shinzawa K, Hayakawa H, Baba K, Sumi-Akamaru H, Tsujimoto Y, Mochizuki H. Progressive Axonal Degeneration of Nigrostriatal Dopaminergic Neurons in Calcium-Independent Phospholipase A2β Knockout Mice.PLoS One. 2016 Apr 14; 11(4): e0153789.
  11. Fujiwara S, Araki K, Matsuo T, Yagi H, Yamada T, Shibata K, Mochizuki H. Behavior of Human α-Synuclein Studied by Quasielastic Neutron Scattering.PLoS One. 2016 Apr 20; 11(4): e0151447.
  12. Uehara T, Beck G, Baba K, Mihara M, Okuno T, Sumi H, Nakatsuji Y, Mochizuki H. Tumefactive brain lesion with rapid cavity formation associated with anti-aquaporin-4 antibody.Neurol Neuroimmunol Neuroinflamm. 2016 Apr 14; 3(3): e230.
  13. Kadowaki A, Miyake S, Saga R, Chiba A, Mochizuki H, Yamamura T. Gut environment-induced intraepithelial autoreactive CD4 (+) T cells suppress central nervous system autoimmunity via LAG-3.Nat Commun. 2016 May 20; 7 :11639.
  14. Furuta M, Sumi-Akamaru H, Takahashi MP, Hayashi YK, Nishino I, Mochizuki H. An elderly-onset limb girdle muscular dystrophy type 1B (LGMD1B) with pseudo-hypertrophy of paraspinal muscles.Neuromuscul Disord. 2016 Sep; 26(9): 593-7.
  15. Fukada K, Matsui T, Furuta M, Hirozawa D, Matsui M, Kajiyama Y, Shimizu M, Kinoshita M, Mochizuki H, Sawada JI, Hazama T. The Motor Unit Number Index of Subclinical Abnormality in Amyotrophic Lateral Sclerosis.J Clin Neurophysiol. 2016 Dec; 33(6): 564-568.
  16. Araki K, Yagi N, Nakatani R, Sekiguchi H, So M, Yagi H, Ohta N, Nagai Y, Goto Y, Mochizuki H. A small-angle X-ray scattering study of alpha-synuclein from human red blood cells.Sci Rep. 2016 Jul 29; 6:30473.
  17. Kato H, Kokunai Y, Dalle C, Kubota T, Madokoro Y, Yuasa H, Uchida Y, Ikeda T, Mochizuki H, Nicole S, Fontaine B, Takahashi MP, Mitake S. A case of non-dystrophic myotonia with concomitant mutations in the SCN4A and CLCN1 genes.J Neurol Sci. 2016 Oct 15; 369:254-8.
  18. Watanabe A, Sasaki T, Yukami T, Kanki H, Sakaguchi M, Takemori H, Kitagawa K, Mochizuki H. Serine racemase inhibition induces nitric oxide-mediated neurovascular protection during cerebral ischemia.Neuroscience. 2016 Dec 17; 339:139-149
  19. Kurinami H, Shimamura M, Nakagami H, Shimizu H, Koriyama H, Kawano T, Wakayama K, Mochizuki H, Rakugi H, Morishita R. A Novel Therapeutic Peptide as a Partial Agonist of RANKL in Ischemic Stroke.Sci Rep. 2016 Nov 29; 6:38062.
  20. Gon Y, Sakaguchi M, Oyama N, Mochizuki H. Diagnostic Utility of Contrast-enhanced 3D T1-weighted Imaging in Acute Cerebral Infarction Associated with Graves Disease.J Stroke Cerebrovasc Dis. 2017 Feb; 26(2): e38-e40.
  21. Ito K, Eguchi Y, Imagawa Y, Akai S, Mochizuki H, Tsujimoto Y. MPP+ induces necrostatin-1- and ferrostatin-1-sensitive necrotic death of neuronal SH-SY5Y cells.Cell Death Discov. 2017 Feb 27; 3:17013.
  22. Ichiyanagi N, Fujimori K, Yano M, Ishihara-Fujisaki C, Sone T, Akiyama T, Okada Y, Akamatsu W, Matsumoto T, Ishikawa M, Nishimoto Y, Ishihara Y, Sakuma T, Yamamoto T, Tsuiji H, Suzuki N, Warita H, Aoki M, Okano H. Establishment of in vitro FUS-associated Familial Amyotrophic Lateral Sclerosis Model Using Human Induced Pluripotent Stem Cells Stem.Cell Reports. 6(4): 496-510. 2016
  23. Miyawaki S, Kawamura Y, Oiwa Y, Shimizu A, Hachiya T, Bono H, Koya I, Okada Y, Kimura T, Tsuchiya Y, Suzuki S, Onishi N, Kuzumaki N, Matsuzaki Y, Narita M, Ikeda E, Okanoya K, Seino K, Saya H, Okano H, Miura K. Tumour resistance in induced pluripotent stem cells derived from naked mole- rats .Nat Commun. 7:11471. 2016
  24. Toyoshima M, Akamatsu W, Okada Y, Ohnishi T, Balan S, Hisano Y, Iwayama Y, Toyota T, Matsumoto T, Itasaka N, Sugiyama S, Tanaka M, Yano M, Dean B, Okano H, Yoshikawa T, Analysis of induced pluripotent stem cells carrying 22q11.2 deletion.Translational Psychiatry6(11): e934. 2016
  25. Ishigaki S, Fujioka Y, Okada Y, Riku Y, Udagawa T, Honda D, Yokoi S, Endo K, Ikenaka K, Takagi S, Iguchi Y, Sahara N, Takashima A, Okano H, Yoshida M, Warita H, Aoki M, Watanabe H, Okado H, Katsuno H, Sobue G. Altered tau isoform ratio caused by loss of Fus and Sfpq function leads to FTLD-like phenotypes.Cell Reports18(5): 1118-1131. 2017
  26. Nakatsuji H, Araki A, Hashizume A, Hijikata Y, Yamada S, Inagaki T, Suzuki K, Banno H, Suga N, Okada Y, Ohyama M, Nakagawa T, Kishida K, Funahashi T, Shimomura I, Okano H, Katsuno M, Sobue G. Correlation of insulin resistance and motor function in spinal and bulbar muscular atrophy.J Neurol. in press