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機能形態学分子細胞学(解剖学第一)

研究室概要

現在、更新中です。 

研究プロジェクト

現在、更新中です。

2019年11月、和氣弘明 新教授が神戸大学医学部システム生理学分野より着任されました。

暫定的に、神戸大学の研究室紹介をご参考ください。

教員

構成員名役職所属
和氣 弘明 教授 分子細胞学
大﨑 雄樹 准教授 分子細胞学
加藤 大輔 助教 分子細胞学

研究実績

  • 2016年
    1. Takatori S, Tatematsu T, Cheng J, Matsumoto J, Akano T, Fujimoto T. Phosphatidylinositol 3,5-Bisphosphate-Rich Membrane Domains in Endosomes and Lysosomes. Traffic, 2016; 17: 154-167.
    2. Takatori S, Fujimoto T. A novel imaging method revealed phosphatidylinositol 3,5-bisphosphate-rich domains in the endosome/lysosome membrane. Commun Integr Biol, 2016; 9: e1145319.
    3. Ohsaki Y, Kawai T, Yoshikawa Y, Cheng J, Jokitalo E, Fujimoto T. PML isoform II plays a critical role in nuclear lipid droplet formation. J Cell Biol, 2016; 212: 29-38.
  • 2015年
    1. Takatori S, Fujimoto T. Microscopy of membrane lipids: how precisely can we define their distribution? Essays Biochem, 2015; 57: 81-91.
    2. Suzuki M, Murakami T, Cheng J, Kano H, Fukata M, Fujimoto T. ELMOD2 is anchored to lipid droplets by palmitoylation and regulates adipocyte triglyceride lipase recruitment. Mol Biol Cell, 2015; 26: 2333-2342.
    3. Imai N, Suzuki M, Hayashi K, Ishigami M, Hirooka Y, Abe T, Shioi G, Goto H, Fujimoto T. Hepatocyte-Specific Depletion of UBXD8 Induces Periportal Steatosis in Mice Fed a High-Fat Diet. PLoS One, 2015; 10: e0127114.
  • 2014年
    1. Yamamura T, Ohsaki Y, Suzuki M, Shinohara Y, Tatematsu T, Cheng J, Okada M, Ohmiya N, Hirooka Y, Goto H, Fujimoto T. Inhibition of Niemann-Pick-type C1-like1 by ezetimibe activates autophagy in human hepatocytes and reduces mutant alpha1-antitrypsin Z deposition. Hepatology, 2014; 59: 1591-1599.
    2. Takatori S, Mesman R, Fujimoto T. Microscopic methods to observe the distribution of lipids in the cellular membrane. Biochemistry, 2014; 53: 639-653.
    3. Ohsaki Y, Suzuki M, Fujimoto T. Open questions in lipid droplet biology. Chem Biol, 2014; 21: 86-96.
    4. Iyoshi S, Cheng J, Tatematsu T, Takatori S, Taki M, Yamamoto Y, Salic A, Fujimoto T. Asymmetrical distribution of choline phospholipids revealed by click chemistry and freeze-fracture electron microscopy. ACS Chem Biol, 2014; 9: 2217-2222.
    5. Fujimoto T, Yamamoto H, Ohsumi Y. Different phosphatidylinositol 3-phosphate asymmetries in yeast and mammalian autophagosomes revealed by a new electron microscopy technique. Autophagy, 2014; 10: 933-935.
    6. Cheng J, Fujita A, Yamamoto H, Tatematsu T, Kakuta S, Obara K, Ohsumi Y, Fujimoto T. Yeast and mammalian autophagosomes exhibit distinct phosphatidylinositol 3-phosphate asymmetries. Nat Commun, 2014; 5: 3207.
  • 2013年
    1. Suzuki M, Shinohara Y, Fujimoto T. Histochemical detection of lipid droplets in cultured cells. Methods Mol Biol, 2013; 931: 483-491.
    2. Suzuki M, Iio Y, Saito N, Fujimoto T. Protein kinase Ceta is targeted to lipid droplets. Histochem Cell Biol, 2013; 139: 505-511.
    3. Ohsaki Y, Cheng J, Yamairi K, Pan X, Hussain MM, Fujimoto T. Inhibition of ADP-ribosylation suppresses aberrant accumulation of lipidated apolipoprotein B in the endoplasmic reticulum. FEBS Lett, 2013; 587: 3696-3702.
    4. Fujimoto T, Ohsaki Y, Suzuki M, Cheng J. Imaging lipid droplets by electron microscopy. Methods Cell Biol, 2013; 116: 227-251.
  • 2012年
    1. Suzuki M, Otsuka T, Ohsaki Y, Cheng J, Taniguchi T, Hashimoto H, Taniguchi H, Fujimoto T. Derlin-1 and UBXD8 are engaged in dislocation and degradation of lipidated ApoB-100 at lipid droplets. Mol Biol Cell, 2012; 23: 800-810.
    2. Suzuki M, Ohsaki Y, Tatematsu T, Shinohara Y, Maeda T, Cheng J, Fujimoto T. Translation inhibitors induce formation of cholesterol ester-rich lipid droplets. PLoS One, 2012; 7: e42379.
    3. Fujita A, Fujimoto T, Ozato-Sakurai N, Suzuki H. A method for efficient observation of intracellular membranes of monolayer culture cells by quick-freeze and freeze-fracture electron microscopy. J Electron Microsc (Tokyo), 2012; 61: 441-446.
  • 2011年
    1. Suzuki M, Shinohara Y, Ohsaki Y, Fujimoto T. Lipid droplets: size matters. J Electron Microsc (Tokyo), 2011; 60 Suppl 1: S101-116.
    2. Ozato-Sakurai N, Fujita A, Fujimoto T. The distribution of phosphatidylinositol 4,5-bisphosphate in acinar cells of rat pancreas revealed with the freeze-fracture replica labeling method. PLoS One, 2011; 6: e23567.
    3. Fujimoto T, Parton RG. Not just fat: the structure and function of the lipid droplet. Cold Spring Harb Perspect Biol, 2011; 3.
  • 2010年
    1. Ohsaki Y, Suzuki M, Shinohara Y, Fujimoto T. Lysosomal accumulation of mTOR is enhanced by rapamycin. Histochem Cell Biol, 2010; 134: 537-544.
    2. Ohsaki Y, Shinohara Y, Suzuki M, Fujimoto T. A pitfall in using BODIPY dyes to label lipid droplets for fluorescence microscopy. Histochem Cell Biol, 2010; 133: 477-480.
    3. Fujita A, Fujimoto T. High-resolution molecular localization by freeze-fracture replica labeling. Methods Mol Biol, 2010; 657: 205-216.
    4. Fujita A, Cheng J, Fujimoto T. Quantitative electron microscopy for the nanoscale analysis of membrane lipid distribution. Nat Protoc, 2010; 5: 661-669.

研究キーワード

ミクログリア、 神経活動、 2光子顕微鏡、 ホログラフィー顕微鏡、 脂肪滴、膜脂質、電子顕微鏡