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産学協同研究講座希少性・難治性がん解析研究講座

研究室概要

　名古屋大学大学院医学系研究科は、2020年1月に、希少性・難治性がん解析研究講座を新たに設置しました。本研究講座は、尿中腫瘍マーカーを用いて、従来検査が困難であった希少性・難治性がんの新しい診断技術を開発することを目的としています。

　これまで名古屋大学医学系研究科小児外科は、日立製作所と共同で、尿中腫瘍マーカーによるがん検査の研究を行ってきました。その結果、尿中代謝物の網羅的解析技術、尿中腫瘍マーカーの抽出技術を踏まえたがん検査モデルにより、いろいろながん腫においてがん患者と健常者を識別できることがわかってきました。加えて、複数の尿中腫瘍マーカーによる代謝物パネル検査法という独自の方法を新たに開発し、良性腫瘍が抽出できる可能性を見出しています。

　本研究講座では、この新しい取り組みを通して、全国の拠点病院と連携しながら、がんの早期診断と患者のQoLを両立させる新しい社会の構築を目指します。

設置期間：令和2年1月～令和6年3月

名古屋大学希少性・難治性がん解析研究講座がスタート ～新しい診断法実用化に向け臨床研究加速～

研究プロジェクト

プレスリリース

新たな神経芽腫尿中バイオマーカーの特定　原著論文

国際学会

  • 2023 ASPHO Conference (May 10-13,2023) The American Society of Pediatric Hematology/Oncology(米国小児血液腫瘍学会)
    • Clinical validation of novel urinary markers for neuroblastoma diagnosis
    Hizuru Amano, Hiroo Uchida, Kazuharu Harada, Atsushi Narita, Shun Kumano, Mayumi Abe, Minoru Sakairi, Chiyoe Shirota2, Takahisa Tainaka, Wataru Sumida, Kazuki Yokota, Satoshi Makita, Tsuyoshi Osawa, Masataka Taguri, Yoshiyuki Takahashi, Akinari Hinoki
  • AACR ANNUAL MEETING 2023（April 14-19,2023）American Association for Cancer Research(米国癌学会)
    • Novel urinary marker for diagnosis and prognosis of neuroblastoma
    Akinari Hinoki, Hizuru Amano, Hiroo Uchida, Atsushi Narita, Shun Kumano, Mayumi Abe, Minoru Sakairi, Chiyoe Shirota, Wataru Sumida, Satoshi Makita, Yoshiyuki Takahashi, Tsuyoshi Osawa
  • 2022 ASPHO Conference (May 4-7, 2022) The American Society of Pediatric Hematology/Oncology(米国小児血液腫瘍学会)
    METABOLOMICS OF URINARY METABOLITES IN CHILDHOOD RHABDOMYOSARCOMA TO DISCOVER NOVEL BIOMARKERS
    • Satoshi Nakano, Hiroo Uchida, Hizuru Amano, Atsushi Narita, Mayumi Abe, Takashi Ishigaki, Minoru Sakairi, Chiyoe Shirota, Wataru Sumida, Satoshi Makita, Aitaro Takimoto, Masamune Okamoto, Akihiro Yasui, Syunya Takada, Yoichi Nakagawa, Yasushi Terui, Masaki Sunagawa, Yoshiyuki Takahashi, Tsuyoshi Osawa, Akinari Hinoki.
  • 2021 ASCO ANNUAL MEETING (June20-23,2021) American Society of Clinical Oncology(米国臨床腫瘍学会)
    Urinary Biomarkers for Monitoring Treatment Response in Neuroblastoma Patients
    Hizuru Amano, Akinari Hinoki, Takashi Ishigaki, Mayumi Abe, Hiroo Uchida , Hirohisa Oda , Minoru Sakairi, Yasushi Terui
  • EACR2021 Virtual Congress (June09-12,2021) European Association for Cancer Research(欧州癌研究会議)
    Identification of urinary biomarker candidates of nephroblastoma
    Hizuru Amano, Akinari Hinoki, Takashi Ishigaki, Mayumi Abe, Hiroo Uchida , Hirohisa Oda , Minoru Sakairi, Yasushi Terui
  • AACR ANNUAL MEETING 2021（April9-14,2021）American Association for Cancer Research(米国癌学会)
    Development of a novel diagnostic system for bile duct cancer using urinary metabolites
    Hizuru Amano, Akinari Hinoki, Takashi Ishigaki, Mayumi Abe, Hiroo Uchida, Hirohisa Oda, Minoru Sakairi, Yasushi Terui
  • 2021 ASPHO Conference (April4-8,2021) The American Society of Pediatric Hematology/Oncology(米国小児血液腫瘍学会)
    NOVEL BIOMARKER DISCOVERY FOR CHILDHOOD RHABDOMYOSARCOMA USING URINARY METABOLITES
    Hizuru Amano, Akinari Hinoki, Takashi Ishigaki, Mayumi Abe, Hiroo Uchida , Hirohisa Oda , Minoru Sakairi, Yasushi Terui

国内学会

  • 第59回 日本小児外科学会学術集会（2022年5月19日～21日） 横紋筋肉腫/腎芽腫/神経芽腫尿中代謝物のCE/MS 解析
  • 第59回 日本小児外科学会学術集会（2022年5月19日～21日）横紋筋肉腫の尿中代謝物解析
  • 第59回 日本小児外科学会学術集会（2022年5月19日～21日）尿中代謝物(MTS，VLA，MTR)による新たな神経芽腫腫瘍マーカーの可能性
  • 第59回 日本小児外科学会学術集会（2022年5月19日～21日）尿中代謝物(MTS，VLA，MTR)による悪性度予測マーカーの可能性
  • 第63回日本小児血液・がん学会学術集会（2021年11 月25 日～11 月27日）神経芽腫における尿中バイオマーカー
  • 第68回日本臨床検査医学会学術集会（2021年11 月11 日～11 月14日）質量分析計を用いた尿中代謝物のメタボロミクスによる新規がん診断法の可能性
  • 第83回日本臨床外科学会総会（2021年11 月18日）名古屋大学・(株)日立製作所 産学協同研究講座（希少性/難治性がん解析研究講座）の医工連携
  • 第48回日本小児栄養消化器肝臓学会（2021年10 月1 日～10 月3日）多施設研究のススメ~小児外科分野から~
  • 第58回日本小児外科学会学術集会The 58th Annual Congress of the Japanese Society of Pediatric Surgeons(JSPS2021) （2021年4 月28 日～4 月30日）神経芽腫の尿中代謝物の安定性
  • 第58回日本小児外科学会学術集会The 58th Annual Congress of the Japanese Society of Pediatric Surgeons(JSPS2021) （2021年4月28日～4月30日）4つの代謝物による神経芽腫超低リスク群の予測
  • 第58回日本小児外科学会学術集会The 58th Annual Congress of the Japanese Society of Pediatric Surgeons(JSPS2021) （2021年4 月28 日～4 月30日）尿中代謝物による神経芽腫のリスク分類

受賞歴

  • 第58回日本小児外科学会学術集会PSIプライズ　横田一樹
    Yokota K, Hinoki A, Hiramatsu K, Amano H, Kawamura M, Kuwatsuka Y, Tainaka T, Shirota C, Sumida W, Makita S, Okamoto M, Takimoto A, Yasui A, Nakagawa Y, Uchida H, Kawakita M. Urinary N1,N12-diacetylspermine as a biomarker for pediatric cancer: a case-control study. Pediatr Surg Int. 2021 Dec;37(12):1659-1665. doi: 10.1007/s00383-021-04987-y. Epub 2021 Aug 28. PMID: 34453590.

産業財産権

  • 胆道がん検査方法　国立大学法人東海国立大学機構,株式会社日立製作所,日立ハイテク
    出願未公開 2022-090965　登録日：令和4年6月3日
  • 新規検査開発サーバ及び新規検査開発方法　国立大学法人東海国立大学機構,株式会社日立製作所
    特願2020-24153　登録日：令和2年2月17日
  • 尿中腫瘍マーカーによるがん検出方法、キット及び装置　国立大学法人東海国立大学機構,株式会社日立製作所
    特許第7226732号　登録日：令和5年2月13日
  • 小児がん検査用尿中代謝物マーカー　国立大学法人東海国立大学機構,株式会社日立製作所
    特許第7016079号　登録日：令和4年1月27日

研究費採択

  • 国立研究開発法人日本医療研究開発機構　令和5年度 「革新的がん医療実用化研究事業」
    【領域1】がんの本態解明に関する研究
    【領域1-15】がんの本態解明に基づいた新規診断技術・革新的創薬等の開発に資する挑戦的研究 【若手育成枠】
    がん悪液質に伴う代謝異常に基づく早期膵癌・胆道癌診断AIの開発（分担者：内田、天野）
  • 国立研究開発法人日本医療研究開発機構　令和5年度 「革新的がん医療実用化研究事業」
    【領域4】患者に優しい新規医療技術開発に関する研究
    【領域4-1】バイオマーカーを用いた診断技術の確立と実用化に関する研究【若手育成枠】
    神経芽腫及び褐色細胞腫における3-Methoxytyramine sulfate/3-Methoxytyramine定量技術の確立と実用化（代表者：天野日出）

教員

構成員名役職所属
檜　顕成 特任教授 希少性・難治性がん解析研究講座、小児外科
天野　日出 特任講師 希少性・難治性がん解析研究講座、小児外科
熊野　峻 客員教授 希少性・難治性がん解析研究講座
高田　安章 産学連携研究員 希少性・難治性がん解析研究講座
坂入　実 客員教授 希少性・難治性がん解析研究講座

研究実績

  • 2023年
    1. Nakagawa Y, Uchida H, Hinoki A, Shirota C, Sumida W, Makita S, Masamune O, Ogata S, Takimoto A, Takada S, Kato D, Gohda Y. Laparoscopic closure of Roux limb perforation during double-balloon endoscopic retrograde cholangiography with laparoscopy-assisted endoscopic hepatolithectomy 30 years after congenital biliary dilatation radical surgery: A case report. Asian J Endosc Surg. 2023 Jan;16(1):118-122. doi: 10.1111/ases.13116. Epub 2022 Aug 11. PMID: 35957492.
    2. Takimoto A, Sumida W, Shirota C, Makita S, Okamoto M, Ogata S, Takada S, Nakagawa Y, Kato D, Goda Y, Hinoki A, Uchida H. Retroperitoneoscopic resection of a large paraganglioma surrounded by the right diaphragmatic crus on the dorsal side of the inferior vena cava: A pediatric case report. Asian J Endosc Surg. 2023 Jan;16(1):131-134. doi: 10.1111/ases.13119. Epub 2022 Aug 18. PMID: 35981721.
    3. Nakagawa Y, Uchida H, Hinoki A, Shirota C, Tainaka T, Sumida W, Makita S, Yasui A, Takimoto A, Guo Y. Laparoscopic bile duct plasty for hilar bile duct stenosis (HBDS) in patients with congenital biliary dilatation: Diagnosis of HBDS by preoperative MRCP and laparoscopic strategy to relieve HBDS. J Hepatobiliary Pancreat Sci. 2023 Apr;30(4):473-481. doi: 10.1002/jhbp.1235. Epub 2022 Sep 11. PMID: 36047878.
    4. Gohda Y, Uchida H, Hinoki A, Shirota C, Sumida W, Makita S, Okamoto M, Ogata S, Takimoto A, Takada S, Nakagawa Y, Kato D, Guo Y. Laparoscopic internal intestinal drainage of bile lakes in a patient with recurrence of jaundice after laparoscopic revision of Kasai portoenterostomy for biliary atresia: A case report. Asian J Endosc Surg. 2023 Apr;16(2):275-278. doi: 10.1111/ases.13133. Epub 2022 Sep 30. PMID: 36180047.
    5. Takimoto A, Amano H, Shirota C, Sumida W, Makita S, Okamoto M, Ogata S, Takada S, Nakagawa Y, Kato D, Gohda Y, Hinoki A, Uchida H. Hemi-circumferential mucosal resection and anastomosis procedure for rectal prolapse following anorectoplasty for anorectal malformations. Surg Today. 2023 May;53(5):628-632. doi: 10.1007/s00595-022-02611-7. Epub 2022 Oct 25. PMID: 36282326.
    6. Nakagawa Y, Uchida H, Hinoki A, Shirota C, Sumida W, Makita S, Amano H, Masamune O, Takimoto A, Ogata S, Takada S, Kato D, Gohda Y, Guo Y. Rare case of a right Bochdalek hernia with retroperitoneal prolapse of organs into the thoracic cavity in infancy: A case report. Asian J Endosc Surg. 2023 Apr;16(2):284-288. doi: 10.1111/ases.13139. Epub 2022 Nov 6. PMID: 36336788.
    7. Takimoto A, Amano H, Sumida W, Shirota C, Yokota K, Makita S, Okamoto M, Ogata S, Takada S, Nakagawa Y, Kato D, Goda Y, Hinoki A, Uchida H. Laparoscopic Duodenal-Caudal Detachment Method: Early Experience of a Novel Technique for Malrotation with Volvulus in Neonates. J Laparoendosc Adv Surg Tech A. 2023 Feb;33(2):220-225. doi: 10.1089/lap.2022.0390. Epub 2022 Nov 16. PMID: 36383112.
    8. Yokoyama S, Ishizu Y, Honda T, Imai N, Ito T, Yamamoto K, Hinoki A, Sumida W, Shirota C, Tainaka T, Makita S, Yokota K, Uchida H, Ishigami M. Endoscopic injection sclerotherapy with polidocanol for cardiac varices in children and adolescents. Arch Pediatr. 2023 Feb;30(2):109-112. doi: 10.1016/j.arcped.2022.11.016. Epub 2022 Dec 9. PMID: 36509625.
    9. Takada S, Shirota C, Uchida H, Amano H, Hinoki A, Sumida W, Makita S, Okamoto M, Takimoto A, Yasui A, Nakagawa Y, Kato D, Guo Y, Tainaka T. Management of Congenital and Postoperative Chylothorax: Use of Thoracoscopic Lymphatic Leak Ligations with Intraoperative ICG Lymphangiography. J Pediatr Surg. 2023 Sep;58(9):1754-1761. doi: 10.1016/j.jpedsurg.2022.11.018. Epub 2022 Dec 5. PMID: 36609065.
    10. Nakagawa Y, Uchida H, Makita S, Yokota K, Hinoki A, Shirota C, Tainaka T, Sumida W, Amano H, Ogata S, Takimoto A, Takada S, Maeda T, Gohda Y. A new type of retropancreatic fascia hernia in the supramesocolic space preoperatively misdiagnosed as a diaphragmatic hernia: report of two cases. Surg Case Rep. 2023 Jan 11;9(1):5. doi: 10.1186/s40792-023-01586-y. PMID: 36627540; PMCID: PMC9832205.
    11. Nakagawa Y, Yokota K, Uchida H, Hinoki A, Shirota C, Tainaka T, Sumida W, Makita S, Amano H, Takimoto A, Ogata S, Takada S, Maeda T, Gohda Y. Laparoscopic restorative proctocolectomy with ileal-J-pouch anal canal anastomosis without diverting ileostomy for total colonic and extensive aganglionosis is safe and feasible with combined Lugol's iodine staining technique and indocyanine green fluorescence angiography. Front Pediatr. 2023 Jan 6;10:1090336. doi: 10.3389/fped.2022.1090336. PMID: 36683800; PMCID: PMC9853408.
    12. Sumida W, Yasui A, Shirota C, Makita S, Okamoto M, Ogata S, Takimoto A, Takada S, Nakagawa Y, Kato D, Gohda Y, Amano H, Guo Y, Hinoki A, Uchida H. Update on aortopexy and posterior tracheopexy for tracheomalacia in patients with esophageal atresia. Surg Today. 2023 Feb 2. doi: 10.1007/s00595-023-02652-6. Epub ahead of print. PMID: 36729255.
    13. Oshima K, Hinoki A, Uchida H, Tanaka Y, Okuno Y, Go Y, Shirota C, Tainaka T, Sumida W, Yokota K, Makita S, Takimoto A, Kano Y, Sawa S. Single-cell RNA sequencing of intestinal immune cells in neonatal necrotizing enterocolitis. Pediatr Surg Int. 2023 Apr 11;39(1):179. doi: 10.1007/s00383-023-05461-7. PMID: 37041419.
    14. Guo Y, Hinoki A, Deie K, Tainaka T, Sumida W, Makita S, Okamoto M, Takimoto A, Yasui A, Takada S, Nakagawa Y, Kato D, Maeda T, Amano H, Kawashima H, Uchida H, Shirota C. Anastomotic time was associated with postoperative complications: a cumulative sum analysis of thoracoscopic repair of tracheoesophageal fistula in a single surgeon's experience. Surg Today. 2023 Apr 23. doi: 10.1007/s00595-023-02687-9. Epub ahead of print. PMID: 37087700.
    15. Nakagawa Y, Uchida H, Shirota C, Tainaka T, Sumida W, Makita S, Amano H, Takimoto A, Ogata S, Takada S, Maeda T, Gohda Y, Guo Y, Hinoki A. Preoperative Contrast Examinations Help Determine the Appropriate Cervical Approach for Congenital Gross Type C Esophageal Atresia: A Report of Two Cases. Am J Case Rep. 2023 Jun 13;24:e938723. doi: 10.12659/AJCR.938723. PMID: 37309107; PMCID: PMC10274229.
    16. Nakagawa Y, Maeda T, Uchida H, Takada S, Hinoki A, Shirota C, Tainaka T, Sumida W, Makita S, Amano H, Takimoto A, Gohda Y. Case Report: Retropancreatic fascia hernia protruding into the thoracic cavity through a Bochdalek hernia. Front Pediatr. 2023 Jun 26;11:1149515. doi: 10.3389/fped.2023.1149515. PMID: 37435174; PMCID: PMC10331128.
    17. Nakagawa Y, Sumida W, Makita S, Uchida H, Hinoki A, Shirota C, Tainaka T, Yokota K, Amano H, Yasui A, Takimoto A, Kato D, Maeda T, Gohda Y. Case report: Laparoscopic gastrojejunostomy for duodenal atresia with situs inversus and preduodenal portal vein: a report of two cases. Front Pediatr. 2023 Jun 27;11:1220393. doi: 10.3389/fped.2023.1220393. PMID: 37441573; PMCID: PMC10333570.
    18. Kato D, Uchida H, Hinoki A, Sumida W, Shirota C, Makita S, Okamoto M, Takimoto A, Takada S, Nakagawa Y. IgG4-related disease of duodenal obstruction due to multiple ulcers in a 12-year-old girl. BMC Pediatr. 2023 Jul 25;23(1):376. doi: 10.1186/s12887-023-04190-z. PMID: 37491193; PMCID: PMC10369806.
    19. Mori M, Yoshizaki K, Watabe S, Ishige M, Hinoki A, Kondo T, Taguchi T, Hasegawa H, Hatata T, Tanuma N, Kirino K, Hirakawa A, Naruto T, Imai M, Koike R, Hosoi K, Kusuda S. Safety, efficacy and pharmacokinetics of palivizumab in off-label neonates, infants, and young children at risk for serious respiratory syncytial virus infection: a multicenter phase II clinical trial. Lancet Reg Health West Pac. 2023 Jul 26;39:100847. doi: 10.1016/j.lanwpc.2023.100847. PMID: 37554997; PMCID: PMC10405310.
    20. Maeda T, Liu J, Uchida H, Amano H, Shirota C, Tainaka T, Sumida W, Makita S, Takimoto A, Takada S, Nakagawa Y, Gouda A, Guo Y, Hinoki A. Robotic versus laparoscopic radical surgery for pediatric congenital biliary dilatation: a comparison of surgical outcomes of a single surgeon's initial experience. Pediatr Surg Int. 2023 Sep 3;39(1):261. doi: 10.1007/s00383-023-05548-1. PMID: 37660350.
    21. Nakagawa Y, Uchida H, Hinoki A, Shirota C, Sumida W, Makita S, Yokota K, Amano H, Yasui A, Kato D, Gohda Y, Maeda T. Refractory esophageal anastomotic stricture after esophageal atresia surgery improved with retrograde balloon dilatation through gastrostomy followed by laparoscopic fundoplication: a case report. Surg Case Rep. 2023 Sep 22;9(1):169. doi: 10.1186/s40792-023-01754-0. PMID: 37737524; PMCID: PMC10516835.
  • 2022年
    1. Taniguchi R, Muramatsu H, Okuno Y, Yoshida T, Wakamatsu M, Hamada M, Shirota C, Sumida W, Hinoki A, Tainaka T, Gotoh Y, Tsuzuki T, Tanaka Y, Kojima S, Uchida H, Takahashi Y. A patient with very early onset FH-deficient renal cell carcinoma diagnosed at age seven. Fam Cancer. 2022 Jul;21(3):337-341. doi: 10.1007/s10689-021-00268-8. Epub 2021 Jun 22. PMID: 34156580.
    2. Shirota C, Hinoki A, Tainaka T, Sumida W, Kinoshita F, Yokota K, Makita S, Amano H, Nakagawa Y, Uchida H. Laparoscopic Kasai portoenterostomy can be a standard surgical procedure for treatment of biliary atresia. World J Gastrointest Surg. 2022 Jan 27;14(1):56-63. doi: 10.4240/wjgs.v14.i1.56. PMID: 35126863; PMCID: PMC8790325.
    3. Nakagawa Y, Uchida H, Amano H, Hinoki A, Shirota C, Sumida W, Yokota K, Makita S, Okamoto M, Takimoto A, Yasui A, Takada S, Maeda T. Safety and feasibility of primary radical surgery for meconium peritonitis considering patients' general condition and perioperative findings. Nagoya J Med Sci. 2022 Feb;84(1):148-154. doi: 10.18999/nagjms.84.1.148. PMID: 35392019; PMCID: PMC8971046.
    4. Tainaka T, Shirota C, Hinoki A, Sumida W, Yokota K, Makita S, Amano H, Tanaka Y, Uchida H. Laparoscopic definitive surgery for congenital biliary dilatation with aggressive hilar bile ductoplasty and complete resection of the intrapancreatic bile duct in pediatric patients is safe and effective, comparable to open surgery. Surg Endosc. 2022 Feb 28. doi: 10.1007/s00464-022-09132-x. Epub ahead of print. PMID: 35226163.
    5. Makita S, Amano H, Kawashima H, Hinoki A, Shirota C, Tainaka T, Sumida W, Yokota K, Okamoto M, Takimoto A, Yasui A, Nakagawa Y, Uchida H. Utility of endoscopic retrograde cholangiopancreatography in management of pediatric pancreaticobiliary disease. BMC Pediatr. 2022 Mar 14;22(1):134. doi: 10.1186/s12887-022-03207-3. PMID: 35287648; PMCID: PMC8919614.
    6. Deie K, Nakagawa Y, Uchida H, Hinoki A, Shirota C, Tainaka T, Sumida W, Yokota K, Makita S, Fujiogi M, Okamoto M, Takimoto A, Yasui A, Takada S, Maeda T. Evaluation of minimally invasive surgical skills training: comparing a neonatal esophageal atresia/tracheoesophageal fistula model with a dry box. Surg Endosc. 2022 Mar 21. doi: 10.1007/s00464-022-09185-y. Epub ahead of print. PMID: 35312850.
    7. Shirota C, Tainaka T, Sumida W, Yokota K, Makita S, Amano H, Okamoto M, Takimoto A, Yasui A, Nakagawa Y, Hinoki A, Uchida H. Single-incision laparoscopic percutaneous extraperitoneal closure (SILPEC) for inguinal hernia with prolapsed ovary. Surg Endosc. 2022 Jun;36(6):4328-4332. doi: 10.1007/s00464-021-08777-4. Epub 2021 Oct 19. PMID: 34668067.
    8. Nakagawa Y, Uchida H, Amano H, Hinoki A, Tainaka T, Shirota C, Sumida W, Yokota K, Makita S, Okamoto M, Takimoto A, Yasui A, Takada S, Kato D. Patients with gastric volvulus recurrence have high incidence of wandering spleen requiring laparoscopic gastropexy and splenopexy. Pediatr Surg Int. 2022 Jun;38(6):875-881. doi: 10.1007/s00383-022-05125-y. Epub 2022 Apr 7. PMID: 35391540.
    9. Tainaka T, Shirota C, Sumida W, Yokota K, Makita S, Amano H, Okamoto M, Takimoto A, Kano Y, Yasui A, Nakagawa Y, Hinoki A, Uchida H. Laparoscopic definitive surgery for choledochal cyst is performed safely and effectively in infants. J Minim Access Surg. 2022 Jul-Sep;18(3):372-377. doi: 10.4103/jmas.JMAS_98_21. PMID: 35708382; PMCID: PMC9306120.
    10. Miyagishima M, Hamada M, Hirayama Y, Muramatsu H, Tainaka T, Shirota C, Hinoki A, Imaizumi T, Nakatochi M, Kamei M, Nishikawa E, Kawashima N, Narita A, Nishio N, Kojima S, Takahashi Y. Risk factors for unplanned removal of central venous catheters in hospitalized children with hematological and oncological disorders. Int J Hematol. 2022 Aug;116(2):288-294. doi: 10.1007/s12185-022-03346-4. Epub 2022 Jun 21. PMID: 35727532.
    11. Yasui A, Hinoki A, Amano H, Shirota C, Tainaka T, Sumida W, Yokota K, Makita S, Okamoto M, Takimoto A, Nakagawa Y, Uchida H. Thoracoscopic posterior tracheopexy during primary esophageal atresia repair ameliorate tracheomalacia in neonates: a single-center retrospective comparative cohort study. BMC Surg. 2022 Jul 25;22(1):285. doi: 10.1186/s12893-022-01738-1. PMID: 35879691; PMCID: PMC9310495.
    12. Nakagawa Y, Uchida H, Hinoki A, Shirota C, Sumida W, Makita S, Masamune O, Ogata S, Takimoto A, Takada S, Kato D, Gohda Y. Laparoscopic closure of Roux limb perforation during double-balloon endoscopic retrograde cholangiography with laparoscopy-assisted endoscopic hepatolithectomy 30 years after congenital biliary dilatation radical surgery: A case report. Asian J Endosc Surg. 2023 Jan;16(1):118-122. doi: 10.1111/ases.13116. Epub 2022 Aug 11. PMID: 35957492.
    13. Takimoto A, Sumida W, Shirota C, Makita S, Okamoto M, Ogata S, Takada S, Nakagawa Y, Kato D, Goda Y, Hinoki A, Uchida H. Retroperitoneoscopic resection of a large paraganglioma surrounded by the right diaphragmatic crus on the dorsal side of the inferior vena cava: A pediatric case report. Asian J Endosc Surg. 2023 Jan;16(1):131-134. doi: 10.1111/ases.13119. Epub 2022 Aug 18. PMID: 35981721.
    14. Nakagawa Y, Uchida H, Hinoki A, Shirota C, Tainaka T, Sumida W, Makita S, Yasui A, Takimoto A, Guo Y. Laparoscopic bile duct plasty for hilar bile duct stenosis (HBDS) in patients with congenital biliary dilatation: Diagnosis of HBDS by preoperative MRCP and laparoscopic strategy to relieve HBDS. J Hepatobiliary Pancreat Sci. 2023 Apr;30(4):473-481. doi: 10.1002/jhbp.1235. Epub 2022 Sep 11. PMID: 36047878.
    15. Kato D, Uchida H, Amano H, Hinoki A, Shirota C, Sumida W, Yokota K, Makita S, Okamoto M, Takimoto A, Yasui A, Takada S, Nakagawa Y. Laparoscopic revision of Kasai portoenterostomy after initial laparoscopic portoenterostomy in patients with biliary atresia: a limited but positive effect on native liver survival. Pediatr Surg Int. 2022 Dec;38(12):1821-1827. doi: 10.1007/s00383-022-05235-7. Epub 2022 Sep 14. PMID: 36104599.
    16. Yasui A, Hinoki A, Amano H, Shirota C, Tainaka T, Sumida W, Yokota K, Makita S, Okamoto M, Takimoto A, Nakagawa Y, Uchida H. Adding a spur valve to laparoscopic portoenterostomy for patients with biliary atresia can achieve a high jaundice clearance rate and lower the number of episodes of cholangitis. Pediatr Surg Int. 2022 Dec;38(12):1881-1885. doi: 10.1007/s00383-022-05230-y. Epub 2022 Sep 14. PMID: 36104601.
    17. Sumida W, Tainaka T, Shirota C, Yokota K, Makita S, Okamoto M, Takimoto A, Yasui A, Takada S, Nakagawa Y, Kato D, Yokoyama S, Ishizu Y, Amano H, Guo Y, Hinoki A, Uchida H. Biochemical markers to predict the development of gastrointestinal bleeding and esophageal varices after portoenterostomy in biliary atresia. Pediatr Surg Int. 2022 Dec;38(12):1799-1805. doi: 10.1007/s00383-022-05243-7. Epub 2022 Sep 17. PMID: 36114864.
    18. Gohda Y, Uchida H, Hinoki A, Shirota C, Sumida W, Makita S, Okamoto M, Ogata S, Takimoto A, Takada S, Nakagawa Y, Kato D, Guo Y. Laparoscopic internal intestinal drainage of bile lakes in a patient with recurrence of jaundice after laparoscopic revision of Kasai portoenterostomy for biliary atresia: A case report. Asian J Endosc Surg. 2023 Apr;16(2):275-278. doi: 10.1111/ases.13133. Epub 2022 Sep 30. PMID: 36180047.
    19. Takimoto A, Amano H, Shirota C, Sumida W, Makita S, Okamoto M, Ogata S, Takada S, Nakagawa Y, Kato D, Gohda Y, Hinoki A, Uchida H. Hemi-circumferential mucosal resection and anastomosis procedure for rectal prolapse following anorectoplasty for anorectal malformations. Surg Today. 2023 May;53(5):628-632. doi: 10.1007/s00595-022-02611-7. Epub 2022 Oct 25. PMID: 36282326.
    20. Nakagawa Y, Uchida H, Hinoki A, Shirota C, Sumida W, Makita S, Amano H, Masamune O, Takimoto A, Ogata S, Takada S, Kato D, Gohda Y, Guo Y. Rare case of a right Bochdalek hernia with retroperitoneal prolapse of organs into the thoracic cavity in infancy: A case report. Asian J Endosc Surg. 2023 Apr;16(2):284-288. doi: 10.1111/ases.13139. Epub 2022 Nov 6. PMID: 36336788.
    21. Takeshita T, Yoshida M, Takei Y, Ouchi A, Hinoki A, Uchida H, Kobayashi T. Development of wearable multi-lead ECG measurement device using cubic flocked electrode. Sci Rep. 2022 Nov 11;12(1):19308. doi: 10.1038/s41598-022-24043-6. PMID: 36369527; PMCID: PMC9652328.
    22. Takimoto A, Amano H, Sumida W, Shirota C, Yokota K, Makita S, Okamoto M, Ogata S, Takada S, Nakagawa Y, Kato D, Goda Y, Hinoki A, Uchida H. Laparoscopic Duodenal-Caudal Detachment Method: Early Experience of a Novel Technique for Malrotation with Volvulus in Neonates. J Laparoendosc Adv Surg Tech A. 2023 Feb;33(2):220-225. doi: 10.1089/lap.2022.0390. Epub 2022 Nov 16. PMID: 36383112.
    23. Shirota C, Hinoki A, Togawa T, Ito S, Sumida W, Makita S, Amano H, Takimoto A, Takada S, Okamoto M, Nakagawa Y, Kato D, Uchida H. Intraoperative indocyanine green fluorescence cholangiography can rule out biliary atresia: A preliminary report. Front Pediatr. 2022 Nov 4;10:1005879. doi: 10.3389/fped.2022.1005879. PMID: 36405823; PMCID: PMC9671931.
    24. Nakagawa Y, Uchida H, Hinoki A, Shirota C, Sumida W, Makita S, Amano H, Okamoto M, Takimoto A, Ogata S, Takada S, Kato D, Gohda Y. Combined negative pressure wound therapy with irrigation and dwell time and artificial dermis prevents infection and promotes granulation formation in a ruptured giant omphalocele: a case report. BMC Pediatr. 2022 Nov 26;22(1):680. doi: 10.1186/s12887-022-03755-8. PMID: 36435753; PMCID: PMC9701383.
    25. Nakagawa Y, Makita S, Uchida H, Hinoki A, Shirota C, Sumida W, Amano H, Okamoto M, Takimoto A, Yasui A, Ogata S, Takada S, Kato D, Gohda Y, Yaohui G. Case report: A giant bilateral inguinal hernia requiring artificial mesh and multi-stage surgery in infancy; hernioplasty with silo placement to prevent acute compartment syndrome. Front Pediatr. 2022 Nov 10;10:1030934. doi: 10.3389/fped.2022.1030934. PMID: 36440330; PMCID: PMC9684311.
    26. Yokoyama S, Ishizu Y, Honda T, Imai N, Ito T, Yamamoto K, Hinoki A, Sumida W, Shirota C, Tainaka T, Makita S, Yokota K, Uchida H, Ishigami M. Endoscopic injection sclerotherapy with polidocanol for cardiac varices in children and adolescents. Arch Pediatr. 2023 Feb;30(2):109-112. doi: 10.1016/j.arcped.2022.11.016. Epub 2022 Dec 9. PMID: 36509625.
    27. Nakagawa Y, Sumida W, Amano H, Uchida H, Hinoki A, Shirota C, Makita S, Okamoto M, Ogata S, Takimoto A, Takada S, Kato D, Gohda Y. Preoperative imaging contributes to pathologically complete resection of the urachal remnant by determining an appropriate surgical approach without unnecessary and excessive surgical invasion: a retrospective study. BMC Urol. 2022 Dec 19;22(1):207. doi: 10.1186/s12894-022-01153-x. PMID: 36536334; PMCID: PMC9764728.
    28. Nakagawa Y, Hinoki A, Amano H, Uchida H, Shirota C, Tainaka T, Sumida W, Yokota K, Makita S, Okamoto M, Takimoto A, Yasui A, Takada S, Kato D. Circumumbilical incision for neonatal abdominal surgery: additional skin incision when there is difficulty in manipulating the intestine. Nagoya J Med Sci. 2022 Nov;84(4):716-722. doi: 10.18999/nagjms.84.4.716. PMID: 36544608; PMCID: PMC9748330.
    29. Takada S, Shirota C, Uchida H, Amano H, Hinoki A, Sumida W, Makita S, Okamoto M, Takimoto A, Yasui A, Nakagawa Y, Kato D, Guo Y, Tainaka T. Management of Congenital and Postoperative Chylothorax: Use of Thoracoscopic Lymphatic Leak Ligations with Intraoperative ICG Lymphangiography. J Pediatr Surg. 2023 Sep;58(9):1754-1761. doi: 10.1016/j.jpedsurg.2022.11.018. Epub 2022 Dec 5. PMID: 36609065.
    30. Nakagawa Y, Makita S, Uchida H, Hinoki A, Shirota C, Sumida W, Amano H, Okamoto M, Takimoto A, Ogata S, Takada S, Kato D, Gohda Y, Guo Y. Refractory tracheoesophageal fistula treated using multi-stage surgery: A case report. Front Pediatr. 2022 Dec 21;10:1053154. doi: 10.3389/fped.2022.1053154. PMID: 36619516; PMCID: PMC9811173.
    31. Nakagawa Y, Yokota K, Uchida H, Hinoki A, Shirota C, Tainaka T, Sumida W, Makita S, Amano H, Takimoto A, Ogata S, Takada S, Maeda T, Gohda Y. Laparoscopic restorative proctocolectomy with ileal-J-pouch anal canal anastomosis without diverting ileostomy for total colonic and extensive aganglionosis is safe and feasible with combined Lugol's iodine staining technique and indocyanine green fluorescence angiography. Front Pediatr. 2023 Jan 6;10:1090336. doi: 10.3389/fped.2022.1090336. PMID: 36683800; PMCID: PMC9853408.
    32. Maeda T, Liu J, Uchida H, Amano H, Shirota C, Tainaka T, Sumida W, Makita S, Takimoto A, Takada S, Nakagawa Y, Gouda A, Guo Y, Hinoki A. Robotic versus laparoscopic radical surgery for pediatric congenital biliary dilatation: a comparison of surgical outcomes of a single surgeon's initial experience. Pediatr Surg Int. 2023 Sep 3;39(1):261. doi: 10.1007/s00383-023-05548-1. PMID: 37660350.
  • 2021年
    1. Yokota K, Hinoki A, Hiramatsu K, Amano H, Kawamura M, Kuwatsuka Y, Tainaka T, Shirota C, Sumida W, Makita S, Okamoto M, Takimoto A, Yasui A, Nakagawa Y, Uchida H, Kawakita M. Urinary N1,N12-diacetylspermine as a biomarker for pediatric cancer: a case-control study. Pediatr Surg Int. 2021
    2. Yokoyama S, Ishizu Y, Ishigami M, Honda T, Kuzuya T, Ito T, Hinoki A, Sumida W, Shirota C, Tainaka T, Makita S, Yokota K, Uchida H, Fujishiro M: Factors associated with bleeding after endoscopic variceal ligation for children. Pediatr Int, 2021
    3. Yokota K, Uchida H, Sakairi M, Abe M, Tanaka Y, Tainaka T, Shirota C, Sumida W, Oshima K, Makita S, Amano H, Hinoki A: Identification of novel neuroblastoma biomarkers in urine samples. Sci Rep 11:4055, 2021
    4. Yamaguchi S, Hinoki A, Tsubouchi K, Amano H, Tajima A, Uchida H: Usefulness of web search queries for early detection of diseases in infants. Nagoya J Med Sci 83:107-111, 2021
    5. Tanaka Y, Tainaka T, Hinoki A, Shirota C, Sumida W, Yokota K, Oshima K, Makita S, Amano H, Takimoto A, Kano Y, Uchida H: Risk factors and outcomes of bile leak after laparoscopic surgery for congenital biliary dilatation. Pediatr Surg Int 37:235-240, 2021
    6. Takimoto A, Sumida W, Amano H, Shirota C, Tainaka T, Yokota K, Makita S, Yasui A, Kanou Y, Hinoki A, Uchida H: Postoperative intestinal obstruction in patients with biliary atresia impedes biliary excretion and results in subsequent liver transplantation. Pediatr Surg Int 37:229-234, 2021
    7. Shirota C, Tainaka T, Sumida W, Yokota K, Makita S, Takimoto A, Amano H, Hinoki A, Ono Y, Uchida H: Thoracoscopic surgery for congenital lung cysts: an attempt to limit pulmonary resection in cases of lesions involving multiple lobes. Pediatr Surg Int 37:213-221, 2021
    8. Shirota C, Kawashima H, Tainaka T, Sumida W, Yokota K, Makita S, Amano H, Takimoto A, Hinoki A, Uchida H: Double-balloon endoscopic retrograde cholangiography can make a reliable diagnosis and good prognosis for postoperative complications of congenital biliary dilatation. Sci Rep 11:11052, 2021
    9. Amano H, Shirota C, Tainaka T, Sumida W, Yokota K, Makita S, Takimoto A, Tanaka Y, Hinoki A, Kawashima H, Uchida H: Late postoperative complications of congenital biliary dilatation in pediatric patients: a single-center experience of managing complications for over 20 years. Surg Today, 2021
  • 2020年
    1. Tanaka T, Amano H, Tanaka Y, Takahashi Y, Tajiri T, Tainaka T, Shirota C, Sumida W, Yokota K, Makita S, Tani Y, Hinoki A, Uchida H: Safe diagnostic management of malignant mediastinal tumors in the presence of respiratory distress: a 10-year experience. BMC Pediatr 20:292, 2020
    2. Shirota C, Murase N, Tanaka Y, Ogura Y, Nakatochi M, Kamei H, Kurata N, Hinoki A, Tainaka T, Sumida W, Yokota K, Makita S, Oshima K, Uchida H: Laparoscopic Kasai portoenterostomy is advantageous over open Kasai portoenterostomy in subsequent liver transplantation. Surg Endosc 34:3375-3381, 2020
    3. Amano H, Miyake K, Hinoki A, Yokota K, Kinoshita F, Nakazawa A, Tanaka Y, Seto Y, Uchida H: Novel zinc alloys for biodegradable surgical staples. World J Clin Cases 8:504-516, 2020

研究キーワード

尿中代謝物、小児がん、希少性・難治性がん、小児外科

名古屋大学大学院医学系研究科病態外科学専攻小児外科

小児外科学 独自ホームページ