Achievement研究成果

原著論文

2024年

• Shinjo K, Umehara T, Niwa H, Sato S, Katsushima K, Sato S, Wang X, Murofushi Y, Suzuki MM, Koyama H, Kondo Y.
  Novel pharmacologic inhibition of lysine-specific demethylase 1 as a potential therapeutic for glioblastoma
  Cancer Gene Ther. 2024, 31(12):1884-1894. PMID: 39501082
• Oishi M, Shinjo K, Takanari K, Muraoka A, Suzuki MM, Kanbe M, Higuchi S, Ebisawa K, Hashikawa K, Kamei Y, Kondo Y.
  Exclusive expression of KANK4 promotes myofibroblast mobility in keloid tissues.
  Sci Rep. 2024, 14: 8725. PMID: 38622256
• Sonobe R, Yang P, Suzuki MM, Shinjo K, Iijima K, Nishiyama N, Miyata K, Kataoka K, Kajiyama H, Kondo Y.
  Long noncoding RNA TUG1 promotes cisplatin resistance in ovarian cancer via upregulation of DNA polymerase eta.
  Cancer Sci. 2024, 115(6): 1910-1923. PMID: 38558246
• Kashiwagi K, Yoshida J, Kimura H, Shinjo K, Kondo Y, Horie K.
  Mutation of the SWI/SNF complex component Smarce1 decreases nucleosome stability in embryonic stem cells and impairs differentiation.
  J Cell Sci. 2024; 137: jcs260467. PMID: 38357971
• Ishibashi K, Ichinose T, Kadokawa R, Mizutani R, Iwabuchi S, Togi S, Ura H, Tange S, Shinjo K, Nakayama J, Nanjo S, Niida Y, Kondo Y, Hashimoto S, Sahai E, Yano S, Nakada M, Hirata E.
  Astrocyte-induced mGluR1 activates human lung cancer brain metastasis via glutamate-dependent stabilization of EGFR.
  Dev Cell. 2024; 59: 579-594. e6. PMID: 38309264

2023年

• Das ND, Chang JC, Hon CC, Kelly ST, Ito S, Lizio M, Kaczkowski B, Watanabe H, Katsushima K, Natsume A, Koseki H, Kondo Y, Minoda A, Umehara T.
  Defining super-enhancers by highly ranked histone H4 multi-acetylation levels identifies transcription factors associated with glioblastoma stem-like properties.
  BMC Genomics. 2023; 24: 574. PMID: 37759202
• Suzuki MM, Iijima K, Ogami K, Shinjo K, Murofushi Y, Xie J, Wang X, Kitano Y, Mamiya A, Kibe Y, Nishimura T, Ohka F, Saito R, Sato S, Kobayashi J, Yao R, Miyata K, Kataoka K, Suzuki HI, Kondo Y. TUG1-mediated R-loop resolution at microsatellite loci as a prerequisite for cancer cell proliferation. Nat Commun. 2023 Aug 22;14(1):4521.PMID:37607907
• Muraoka A, Suzuki M, Hamaguchi T, Watanabe S, Iijima K , Murofushi Y ,Shinjo K, Osuka S, Hariyama Y, Ito M, Ohno K, Kiyono T, Kyo S, Iwase A, Kikkawa F, Kajiyama H, Kondo Y. Fusobacterium infection facilitates the development of endometriosis through the phenotypic transition of endometrial fibroblasts. Sci Transl Med. 2023 Jun 14;15(700):eadd1531.PMID:37315109
• Yamaguchi J, Ohka F, Kitano Y, Maeda S, Motomura K, Aoki K, Takeuchi K, Nagata Y, Hattori H, Tsujiuchi T, Motomura A, Nishikawa T, Kibe Y, Shinjo K, Kondo Y, Saito R. Rapid detection of the MYD88 L265P mutation for pre- and intra-operative diagnosis of primary central nervous system lymphoma. Cancer Sci.2023 Jun;114(6):2544-2551.PMID:36859777
• Imai K, Ishimoto T, Doke T, Tsuboi T, Watanabe Y, Katsushima K, Suzuki M, Oishi H, Furuhashi K, Ito Y, Kondo Y, Maruyama S. Long non-coding RNA lnc-CHAF1B-3 promotes renal interstitial fibrosis by regulating EMT-related genes in renal proximal tubular cells.Mol Ther Nucleic Acids. 2022 Dec 23;31:139-150.PMID:36700051
• Yamaguchi J, Ohka F, Lushun C, Motomura K, Aoki K, Takeuchi K, Nagata Y, Ito S, Mizutani N, Ohno M, Suzaki N, Takasu S, Seki Y, Kano T, Wakabayashi K, Oyama H, Kurahashi S, Tanahashi K, Hirano M, Shimizu H, Kitano Y, Maeda S, Yamazaki S, Wakabayashi T, Kondo Y, Natsume A, Saito R. CD79B Y196 mutation is a potent predictive marker for favorable response to R-MPV in primary central nervous system lymphoma.Cancer Med. 2023 Mar;12(6):7116-7126. PMID:36478416

2022年

• Matsumoto Y, Shinjo K, Mase S, Fukuyo M, Aoki K, Ozawa F, Yoshihara H, Goto S, Kitaori T, Ozaki Y, Takahashi S, Kaneda A, Sugiura-Ogasawara M, Kondo Y. Characteristic DNA methylation profiles of chorionicvilli in recurrent miscarriage.Sci Rep 2022 Jul 27;12(1):11673. PMID:35896560
• Suehiro Y, Suenaga S, Kunimune Y, Yada S, Hamamoto K, Tsuyama T, Amano S, Matsui H, Higaki S, Fujii I, Suzuki C, Hoshida T, Matsumoto T, Fujimoto Y, Kaino S, Shinjo K, Kondo Y, Sakaida I, Takami T, Nagano H, Yamasaki T. CA19-9 in Combination with Methylated HOXA1 and SST Is Useful to Diagnose Stage I Pancreatic Cancer.Oncology. 2022; 100(12):674-684.PMID:36244341

2021年

• Yamazaki S, Ohka F, Hirano M, Shiraki Y, Motomura K, Tanahashi K, Tsujiuchi T, Motomura A, Aoki K, Shinjo K, Murofushi Y, Kitano Y, Maeda S, Kato A, Shimizu H, Yamaguchi J, Adilijiang A, Wakabayashi T, Saito R, Enomoto A, Kondo Y, Natsume A. Newly Established Patient-derived Organoid Model of Intracranial Meningioma.Neuro Oncol. 2021 Nov 23(11): 1936-1948. PMID:34214169

2020年

• Tasaki T, Suzuki M, Katsushima K, Shinjo K, Iijima K, Murofushi Y, Naiki-Ito A, Hayashi K, Qiu C, Takahashi A, Tanaka Y, Kawaguchi T, Sugawara M, Kataoka T, Taito M, Miyata K, Kataoka K, Noda T, Gao W, Kataoka H, Takahashi S, Kimura K, Kondo Y. Cancer-specific targeting of taurine upregulated gene 1 enhances the effects of chemotherapy in pancreatic cancer. Cancer Res. 2021 ; canres.3021.2020. PMID:33648930
• Kato H, Kushima I, Mori D, Yoshimi A, Branko A, Nawa Y, Toyama M, Furuta S, Yanjie Yu, Ishizuka K, Kimura H, Arioka Y, Tsujimura K, Morikawa M, Okada T, Inada T, Nakatochi M, Shinjo K, Kondo Y, Kaibuchi K, Funabiki Y, Kimura R, Suzuki T, Yamakawa K, Ikeda M, Iwata N, Takahashi T, Suzuki M, Okahisa Y, Takaki M, Egawa J, Someya T, Ozaki N. Rare genetic variants in the gene encoding histone lysine demethylase 4C (KDM4C) and their contributions to susceptibility to schizophrenia and autism spectrum disorder. Transl Psychiatry. 2020 ; 10(1): 421. PMID:33279929
• Muraoka A, Osuka S, Kiyono T, Suzuki M, Yokoi A, Murase T, Nishino K, Niimi K, Nakamura T, Goto M, Kajiyama H, Kondo Y, Kikkawa F. Establishment and characterization of cell lines from human endometrial epithelial and mesenchymal cells from patients with endometriosis. Fertil Steril Sci. 2020 ; 2 (2): 195-205. PMID:32891059
• Suenaga M, Fujii T, Yamada S, Hayashi M, Shinjo K, Takami H, Niwa Y, Sonohara F, Shimizu D, Kanda M, Kobayashi D, Tanaka C, Nakayama G, Koike M, Fujiwara M, Kondo Y, Kodera Y. Peritoneal Lavage Tumor DNA as a Novel Biomarker for Predicting Peritoneal Recurrence in Pancreatic Ductal Adenocarcinoma. Ann Surg Oncol. 2020 PMID:32875467
• Hirata E, Ishibashi K, Kohsaka S, Shinjo K, Kojima S, Kondo Y, Mano H, Yano S, Kiyokawa E, Sahai E. The Brain Microenvironment Induces DNMT1 Suppression and Indolence of Metastatic Cancer Cells.　iScience. 2020 23(9):101480. PMID:32891059
• Totani H, Shinjo K, Suzuki M, Katsushima K, Mase S, Masaki A, Ito A, Masaki R, Kusumoto S, Komatsu H, Ishida T, Inagaki H, Iida S, Kondo Y. Autocrine HGF/c-Met signaling pathway confers aggressiveness in lymph node adult T-cell leukemia/lymphoma. Oncogene. 2020 39(35):5782-5794. PMID:32747750
• Shinjo K, Hara K, Nagae G, Umeda T, Katsushima K, Suzuki M, Murofushi Y, Umezu Y, Takeuchi I, Takahashi S, Okuno Y, Matsuo K, Ito H, Tajima S, Aburatani H, Yamao K, Kondo Y. A Novel Sensitive Detection Method for DNA Methylation in Circulating Free DNA of Pancreatic Cancer. PLoS One. 2020 ;15(6):e0233782. PMID:32520974
• Maeda S, Ohka F, Okuno Y, Aoki K, Motomura K, Takeuchi K, Kusakari H, Yanagisawa N, Sato S, Yamaguchi J, Tanahashi K, Hirano M, Kato A, Shimizu H, Kitano Y, Yamazaki S, Yamashita S, Takeshima H, Shinjo K, Kondo Y, Wakabayashi T, Natsume A. H3F3A mutant allele specific imbalance in an aggressive subtype of diffuse midline glioma, H3 K27M-mutant. Acta Neuropathol Commun. 2020 ; 8(1) : 8. PMID:32019606

2019年

• Ohka F, Shinjo K, Deguchi S, Matsui Y, Okuno Y, Katsushima K, Suzuki M, Kato A, Ogino N, Yamamichi A, Aoki K, Suzuki H, Sato S, Arul Rayan N, Prabhakar S, Göke J, Shimamura T, Maruyama R, Takahashi S, SUzumura A, Kimura H, Wakabayashi T, Zong H, Natsume A, Kondo Y. Pathogeneic Epigenetic Consequences of Genetic Alterations in IDH-Wild-Type Diffuse Astrocytic Gliomas. Cancer Res. 2019; 79(19):4814-27. PMID:31431463
• Murashima A, Shinjo K, Katsushima K, Onuki T, Kondoh Y, Osada H, Kagaya N, Shinya K, Kimura H, Yoshida M, Murakami S, Kondo Y. Identification of a Chemical Modulator of EZH2-mediated Silencing by Cell-based High-throughput Screening Assay. J Biochem. 2019 PMID:30690451　（第28回JB論文賞を受賞しました！）
• Kondo N, Tohnai G, Sahashi K, Iida M, Kataoka M, Nakatsuji H, Tsutsumi Y, Hashizume A, Adachi H, Koike H, Shinjo K, Kondo Y, Sobue G, Katsuno M. DNA methylation inhibitor attenuates polyglutamine-induced neurodegeneration by regulating Hes5. EMBO Mol Med. 2019 PMID:30940675
• Watanabe S, Hayashi K, Toh K, Kim HJ, Liu X, Chaya H, Fukushima S, Katsushima K, Kondo Y, Uchida S, Ogura S, Nomoto T, Takemoto H, Cabral H, Kinoh H, Tanaka HY, Kano MR, Matsumoto Y, Fukuhara H, Uchida S, Nangaku M, Osada K, Nishiyama N, Miyata K, Kataoka K. In vivo rendezvous of small nucleic acid drugs with charge-matched block catiomers to target cancers. Nat Commun. 2019 Apr 24;10(1):1894. PMID:31019193
• Mase S, Shinjo K, Totani H, Katsushima K, Arakawa A, Takahashi S, Lai HC, Lin RI, Chan MWY, Sugiura-Ogasawara M, Kondo Y. ZNF671 DNA methylation as a molecular predictor for the early recurrence of serous ovarian cancer. Cancer Sci. 2019; 110:1105-1116, PMID:30633424

2018年

• Hirano M, Ohka F, Maeda S, Chalise L, Yamamichi A, Aoki K, Kato A, Tanahashi K, Motomura K, Nishimura Y, Hara M, Shinjo K, Kondo Y, Wakabayashi T, Natsume A. A novel high-sensitivity assay to detect a small fraction of mutant IDH1 using droplet digital PCR. Brain Tumor Pathol. 2018; 35: 97-105, PMID:29460200 .

2017年

• Minami N, Maeda Y, Shibao S, Arima Y, Ohka F, Kondo Y, Maruyama K, Kusuhara M, Sasayama T, Kohmura E, Saya H, Sampetrean O. Organotypic brain explant culture as a drug evaluation system for malignant brain tumors. Cancer Med. 2017; 6: 2635-2645, PMID: 28980419 .
• Deguchi S, Katsushima K, Hatanaka A, Shinjo K, Ohka F, Wakabayashi T, Zong H, Natsume A, Kondo Y.Oncogenic effects of evolutionarily conserved noncoding RNA ECONEXIN on gliomagenesis. Oncogene. 20176 Apr 3.doi: 10.1038/onc.2017.88. . PMID:28368417 .

2016年

• Katsushima K, Natsume A, Ohka F, Shinjo K, Hatanaka A, Ichimura N, Sato S, Takahashi S, Kimura H, Totoki Y, Shibata T, Naito M, Kim HJ, Miyata K, Kataoka K, Kondo Y. Targeting the Notch-regulated non-coding RNA TUG1 for glioma treatment. Nat Commun. 2016 Dec 6;7:13616. PMID:27922002 .
• Fujii S, Shinjo K, Matsumoto S, Harada T, Nojima S, Sato S, Usami Y, Toyosawa S, Morii E, Kondo Y, Kikuchi A.Epigenetic upregulation of ARL4C, due to DNA hypomethylation in the 3'-untranslated region, promotes tumorigenesis of lung squamous cell carcinoma. Oncotarget. 2016 Dec 6;7(49):81571-81587. PMID:27835592 .
• Murakami-Tonami Y, Ikeda H, Yamagishi R, Inayoshi M, Inagaki S, Kishida S, Komata Y, Jan Koster, Takeuchi I, Kondo Y, Maeda T, Sekido Y, Murakami H, Kadomatsu K. SGO1 is involved in the DNA damage response in MYCN-amplified neuroblastoma cells. Sci Rep. 2016 Aug 19;6:31615. PMID: 27539729.
• Torigata K, Okuzaki D, Mukai S, Hatanaka A, Ohka F, motooka D, Nakamura S, Ohkawa Y, Yabuta N, Kondo Y, Nojima H. LATS2 positively regulates Polycomb repressive complex 2. PLOS One. 2016 Jul 19;11: e0158562. PMID:27434182.
• Sato S, Katsushima K, Shinjo K, Hatanaka A, Ohka F, Suzuki S, Naiki-Ito A, Soga N, Takahashi S, Kondo Y. Histone Deacetylase Inhibition in Prostate Cancer Triggers miR-320-Mediated Suppression of the Androgen Receptor. Cancer Res. 2016 May 23: e0115350. PMID: 27216188.
• Nohara K, Okamura K, Suzuki T, Murai H, Ito T, Shinjo K, Takumi S, Michikawa T, Kondo Y, Hata K. Augmenting effects of gestational arsenite exposure of C3H mice on the hepatic tumors of the F2 male offspring via the F1 male offspring. J Appl Toxicol. 2016 ; jat.3149 : e0115350. PMID: 25825268.

2015年

• Fujii S, Srivastava V, Hegde A, Kondo Y, Shen L, Hoshino K, Gonzalez Y, Wang J, Sasai K, Ma X, Katayama H, Estecio MR, Hamilton SR, Wistuba I, Issa JP, Sen S. Regulation of AURKC expression by CpG island methylation in human cancer cells. Tumour Biol. PMID:. 25990457.
• Suzuki H, Aoki K, Chiba K, Sato Y, Shiozawa Y, Shiraishi Y, Shimamura T, Niida A, Motomura K, Ohka F, Yamamoto T, Tanahashi K, Ranjit M, Wakabayashi T, Yoshizato T, Kataoka K, Yoshida K, Nagata Y, Sato- Otsubo A, Tanaka H, Sanada M, Kondo Y, Nakamura H, Mizoguchi M, Abe T, Muragaki Y, Watanabe R, Ito I, Miyano S, Natsume A, Ogawa S. Mutational landscape and clonal architecture in grade II and III gliomas. Nat Genet. 2015 ; 47 : 458-68 . PMID: 25848751.
• Ichimura N, Shinjo K, An B, Shimizu Y, Yamao K, Ohka F, Katsushima K, Hatanaka A, Tojo M, Yamamoto E, Suzuki H, Ueda M, Kondo Y. Aberrant TET1 Methylation Closely Associated with CpG Island Methylator Phenotype in Colorectal Cancer. Cancer Prev Res (Phila). 2015 Jun 10; PMID:26063725.
• Gao W, Gu Y, Li Z, Cai H, Peng Q, Tu M, Kondo Y, Shinjo K, Zhu Y, Zhang J, Sekido Y, Han B, Qian Z, Miao Y. miR-615-5p is epigenetically inactivated and functions as a tumor suppressor in pancreatic ductal adenocarcinoma. Oncogene. 2015 ; 34 : 1629-40 . PMID: 24769899.
• Ishikawa K, Tsunekawa S, Ikeniwa M, Izumoto T, Iida A, Ogata H, Uenishi E, Seino Y, Ozaki N, Sugimura Y, Hamada Y, Kuroda A, Shinjo K, Kondo Y, Oiso Y. Long-Term Pancreatic Beta Cell Exposure to High Levels of Glucose but Not Palmitate Induces DNA Methylation within the Insulin Gene Promoter and Represses Transcriptional Activity. adenocarcinoma. Oncogene. PLoS One. 2015 ; 10 : e0115350. PMID: 25658116.
• Tanaka I, Osada H, Fujii M, Fukatsu A, Hida T, Horio Y, Kondo Y, Sato A, Hasegawa Y, Tsujimura T, Sekido Y. LIM-domain protein AJUBA suppresses malignant mesothelioma cell proliferation via Hippo signaling cascade. Oncogene. 2015 : 34 : 73-83 PMID:24336325.

2014年

• Murakami-Tonami Y, Kishida S, Takeuchi I, Katou Y, Maris JM, Ichikawa H, Kondo Y, Sekido Y, Shirahige K, Murakami H, Kadomatsu K. Inactivation of SMC2 shows a synergistic lethal response in MYCN-amplified neuroblastoma cells. Cell Cycle. 2014 ; 13 : 1115-31 . PMID: 24553121.
• Tahara T, Yamamoto E, Madireddi P, Suzuki H, Maruyama R, Chung W, Garriga J, Jelinek J, Yamano HO, Sugai T, Kondo Y, Toyota M, Issa JP, Estécio MR. Colorectal carcinomas with CpG island methylator phenotype 1 frequently contain mutations in chromatin regulators. Gastroenterology. 2014; 146: 530-38. PMID:24211491.
• Tahara T, Yamamoto E, Suzuki H, Maruyama R, Chung W, Garriga J, Jelinek J, Yamano HO, Sugai T, An B, Shureiqi I, Toyota M, Kondo Y, Estécio MR, Issa JP. Fusobacterium in colonic flora and molecular features of colorectal carcinoma. Cancer Res. 2014; 74: 1311-8. PMID:24385213.
• Okamoto Y, Shinjo K, Shimizu Y, Sano T, Yamao K, Gao W, Fujii M, Osada H, Sekido Y, Murakami S, Tanaka Y, Joh T, Sato S, Takahashi S, Wakita T, Zhu J, Issa JP, Kondo Y. Hepatitis virus infection affects DNA methylation in mice with humanized livers. Gastroenterology. 2014; 146: 562-72. PMID:24184133.
• Fukatsu A, Ishiguro F, Tanaka I, Kudo T, Nakagawa K, Shinjo K, Kondo Y, Fujii M, Hasegawa Y, Tomizawa K, Mitsudomi T, Osada H, Hata Y, Sekido Y. RASSF3 downregulation increases malignant phenotypes of non-small cell lung cancer. Lung Cancer. 2014 ; 83 : 23-9 . PMID: 24246507.

2013年

• Natsume A, Ito M, Katsushima K, Ohka F, Hatanaka A, Shinjo K, Sato S, Takahashi S, Ishikawa Y, Takeuchi I, Shimogawa H, Uesugi M, Okano H, Kim SU, Wakabayashi T, Issa JP, Sekido Y, Kondo Y. Chromatin regulator PRC2 is a key regulator of epigenetic plasticity in glioblastoma. Cancer Res. 73: 4559-70, 2013. PMID:23720055.
• Xue X, Gao W, Sun B, Xu Y, Han B, Wang F, Zhang Y, Sun J, Wei J, Lu Z, Zhu Y, Sato Y, Sekido Y, Miao Y, Kondo Y. Vasohibin 2 is transcriptionally activated and promotes angiogenesis in hepatocellular carcinoma. Oncogene. 2013; 32: 1724-34. PMID:22614011.
• Ishiguro F, Murakami H, Mizuno T, Fujii M, Kondo Y, Usami N, Taniguchi T, Yokoi K, Osada H, Sekido Y. Membranous expression of activated leukocyte cell adhesion molecule contributes to poor prognosis and malignant phenotypes of non-small-cell lung cancer. J Surg Res. 2013; 179: 24-32. PMID: 22985775.

2012年

• Oki Y, Kondo Y, Yamamoto K, Ogura M, Kasai M, Kobayashi Y, Watanabe T, Uike N, Ohyashiki K, Okamoto SI, Ohnishi K, Tomita A, Miyazaki Y, Tohyama K, Mukai HY, Hotta T, Tomonaga M. A phase I/II study of decitabine in patients with myelodysplastic syndrome: a multi-center study in Japan. Cancer Sci. 2012; 103: 1839-47. PMID:22816487.
• Katsushima K, Shinjo K, Natsume A, Ohka F, Fujii M, Osada H, Sekido Y, Kondo Y. Contribution of microRNA-1275 to Claudin11 suppression via a polycomb-mediated silencing mechanism in human glioma stem-like cells. J Biol Chem. 2012; 287: 27396-406. PMID:22736761.
• Shinjo K, Okamoto Y, An B, Yokoyama T, Takeuchi I, Fujii M, Osada H, Usami N, Hasegawa Y, Ito H, Hida T, Fujimoto N, Kishimoto T, Sekido Y, Kondo Y. Integrated analysis of genetic and epigenetic alterations reveals CpG island methylator phenotype associated with distinct clinical characters of lung adenocarcinoma. Carcinogenesis. 2012; 33: 1277-85. PMID:22532250.
• Murata T, Kondo Y, Sugimoto A, Kawashima D, Saito S, Isomura H, Kanda T, Tsurumi T. Epigenetic Histone Modification of Epstein-Barr virus BZLF1 Promoter during Latency and Reactivation in Raji Cells. Journal of Virology. 2012; 86: 4752-61. PMID:22357272.
• Ishiguro F, Murakami H, Mizuno T, Fujii M, Kondo Y, Usami N, Yokoi K, Osada H, Sekido Y. Activated Leukocyte Cell Adhesion Molecule (ALCAM) Promotes Malignant Phenotypes of Malignant Mesothelioma. Journal of Thoracic Oncology. 2012; 7: 890-9. PMID:22722789.
• Kishida Y, Natsume A, Toda H, Toi Y, Motomura K, Koyama H, Matsuda K, Nakayama O, Sato M, Suzuki M, Kondo Y, Wakabayashi T. Correlation between quantified promoter methylation and enzymatic activity of O6-methylguanine-DNA methyltransferases in glioblastomas. Tumour Biol. 2012; 33: 373-81. PMID:22274924.
• Mizuno T, Murakami H, Fujii M, Ishiguro F, Tanaka I, Kondo Y, Akatsuka S, Toyokuni S, Yokoi K, Osada H, Sekido Y. YAP induces malignant mesothelioma cell proliferation by upregulating transcription of cell cycle-promoting genes. Oncogene. 2012; 31: 5117-22. PMID:22286761.
• Fujii M, Toyoda T, Nakanishi H, Yatabe Y, Sato A, Matsudaira Y, Ito H, Murakami H, Kondo Y, Kondo E, Hida T, Tsujimura T, Osada H, Sekido Y. TGF-β synergizes with defects in the Hippo pathway to stimulate human malignant mesothelioma growth. J Exp Med. 2012; 209: 479-94. PMID:22329991.
• Kishida Y, Natsume A, Kondo Y, Takeuchi I, An B, Okamoto Y, Shinjo K, Saito K, Ando H, Ohka F, Sekido Y, Wakabayashi T. Epigenetic subclassification of meningiomas based on genome-wide DNA methylation analyses. Carcinogenesis. 2012; 33: 436-41. PMID:22102699.
• Okamoto Y, Sawaki A, Ito S, Nishida T, Takahashi T, Toyota M, Suzuki H, Shinomura Y, Takeuchi I, Shinjo K, An B, Ito H, Yamao K, Fujii M, Murakami H, Osada H, Kataoka H, Joh T, Sekido Y, Kondo Y. Aberrant DNA methylation associated with aggressiveness of gastrointestinal stromal tumour. Gut. 2012; 61: 392-401. PMID:21708825.

2011年

• Konishi K, Watanabe Y, Shen L, Guo Y, Castoro RJ, Kondo K, Chung W, Ahmed S, Jelinek J, Boumber YA, Estecio MR, Maegawa S, Kondo Y, Itoh F, Imawari M, Hamilton SR, Issa JP. DNA methylation profiles of primary colorectal carcinoma and matched liver metastasis. PloS One. 2011; 6: e27889. PMID:22132162.
• Ohka F, Natsume A, Motomura K, Kishida Y, Kondo Y, Abe T, Nakasu Y, Namba H, Wakai K, Fukui T, Momota H, Iwami K, Kinjo S, Ito M, Fujii M, Wakabayashi T. The Global DNA Methylation Surrogate LINE-1 Methylation Is Correlated with MGMT Promoter Methylation and Is a Better Prognostic Factor for Glioma. PloS One. 2011; 6: e23332. PMID:21829728.
• Cheng AS, Lau SS, Chen Y, Kondo Y, Li MS, Feng H, Ching AK, Cheung KF, Wong HK, Tong JH, Jin H, Choy KW, Yu J, To KF, Wong N, Huang TH, Sung JJ. EZH2-mediated concordant repression of Wnt antagonists promotes β-catenin-dependent hepatocarcinogenesis. Cancer Res. 2011; 71: 4028-39. PMID:21512140.
• Ju H, An B, Okamoto Y, Shinjo K, Kanemitsu Y, Komori K, Hirai T, Shimizu Y, Sano T, Sawaki A, Tajika M, Yamao K, Fujii M, Murakami H, Osada H, Ito H, Takeuchi I, Sekido Y, Kondo Y. Distinct profiles of epigenetic evolution between colorect cancers with and without metastasis. Am J Pathol. 2011; 178: 1835-46. PMID:21406167.
• Nagashio R, Arai E, Ojima H, Kosuge T, Kondo Y, Kanai Y. Carcinogenetic risk estimation based on quantification of DNA methylation levels in liver tissue at the precancerous stage. Int J Cancer. 2011; 129: 1170-9. PMID:21400512.
• Murakami M, Mizuno T, Taniguchi T, Fujii M, Ishiguro F, Fukui T, Akatsuka S, Horio Y, Hida T, Kondo Y, Toyokuni S, Osada H, Sekido Y. LATS2 is a tumor suppressor gene of malignant mesothelioma. Cancer Res. 2011; 71: 873-83. PMID:21245096.
• Motomura K, Natsume A, Kishida Y, Higashi H, Kondo Y, Nakasu Y, Abe T, Namba H, Wakai K, Wakabayashi T. Benefits of interferon-β and temozolomide combination therapy for newly diagnosed primary glioblastoma with the unmethylated MGMT promoter: a multicenter study. Cancer. 2011; 117: 1721-30. PMID:21472719.

2010年

• Estecio MR, Gallegos J, Vallot C, Castoro RJ, Chung W, Maegawa S, Oki Y, Kondo Y, Jelinek J, Shen L, Hartung H, Aplan PD, Czerniak BA, Liang S, Issa JPJ. Genome architecture marked by retrotransposons modulates predisposition to DNA methylation in cancer. Genome Res. 2010; 20: 1369-82. PMID:20716667.
• An B, Kondo Y, Okamoto Y, Shinjo K, Kanemitsu Y, Komori K, Hirai T, Sawaki A, Tajika M, Nakamura T, Yamao K, Yatabe Y, Fujii M, Murakami H, Osada H, Tani T, Matsuo K, Shen L, Issa JPJ, Sekido Y. Characteristic methylation profile in CpG island methylator phenotype-negative distal colorectal cancers. Int J Cancer. 2010; 127: 2095-105. vPMID:20131317.
• Shen L, Kantarjian H, Guo Y, Lin E, Shan J, Huang X, Berry D, Ahmed S, Zhu W, Pierce S, Kondo Y, Oki Y, Jelinek J, Hussain S, Estey E, Issa JPJ. DNA methylation predicts survival and response to therapy in patients with myelodysplastic syndromes. J Clin Oncol. 2010; 28: 605-13. vPMID:20038729.

2009年

• Suzuki Y, Murakami H, Kawaguchi K, Tanigushi T, Fujii M, Shinjo K, Kondo Y, Osada H, Shimokata K, Horio Y, Hasegawa Y, Hida Y, Sekido Y. Activation of the PI3K-AKT pathway in human malignant mesothelioma cells. Molecular Medicine Reports. 2009; 2: 181-8. PMID:21475810.
• Ohno M, Natsume A, Kondo Y, Iwamizu H, Motomura K, Toda H , Ito M, Kato T, Wakabayashi T. The modulation of microRNAs by Type I Interferon through the activation of STAT3 in human glioma. Mol Cancer Res. 2009; 7: 2022-30. PMID:19934272.
• Goto Y, Shinjo K, Kondo Y, Shen L, Toyota M, Suzuki H, Gao W, An B, Fujii M, Murakami H, Osada H, Taniguchi T, Usami N, Kondo M, Hasegawa Y, Shimokata K, Matsuo K, Hida T, Fujimoto N, Kishimoto T, Issa JPJ, Sekido Y. Epigenetic profiles distinguish malignant pleural mesothelioma from lung adenocarcinoma. Cancer Res. 2009; 69: 9073-82. PMID:19887624.
• Kawaguchi K, Murakami H, Taniguchi T, Fujii M, Kawata S, Fukui T, Kondo Y, Osada H, Usami N, Yokoi K, Ueda Y, Yatabe Y, Ito M, Horio Y, Hida T, Sekido Y. Combinational inhibition of MET and EGFR suppresses proliferation of malignant mesothelioma cells. Carcinogenesis. 2009; 30: 1097-105. PMID:19380521.
• Yuki K, Natsume A, Yokoyama H, Kondo Y, Ohno M, Kato T, Chansakul P, Ito M, Kim S, Wakabayashi T. Induction of oligodendrogenesis in glioblastoma-initiating cells by IFN-mediated activation of STAT3 signaling. Cancer Lett. 2009; 284: 71-9. PMID:19457609.
• Oi S, Natsume A, Ito M, Kondo Y, Shimato S, Maeda Y, Saito K, Wakabayashi T. Synergistic induction of NY-ESO-1 antigen expression by a novel histone deacetylase inhibitor, valproic acid with 5-aza-2’-deoxycytidine, in glioma cells. J Neurooncol. 2009; 92: 15-22. PMID:19030781.

2008年

• Yokoyama T, Osada H, Murakami H, Tatematsu Y, Taniguchi T, Kondo Y, Yatabe Y, Hasegawa Y, Shimokata K, Horio Y, Hida T, Sekido Y. YAP1 is involved in mesothelioma development and negatively regulated by Merlin through phosphorylation. Carcinogenesis. 2008 ; 29 : 2139-46 . PMID:18725387.
• Yamamoto E, Toyota M, Suzuki H, Kondo Y, Sanomura T, Murayama Y, Ohe-Toyota M, Maruyama R, Nojima M, Ashida M, Fujii K, Sasaki Y, Hayashi N, Mori M, Imai K, Tokino T, Shinomura Y. LINE-1 hypomethylation is associated with increased CpG island methylation in helicobacter pylori-related enlarged-fold gastritis. Cancer Epidemiol Biomarkers Prev. 2008 ; 17 : 2555-64 . PMID:18842996.
• Gao W, Kondo Y, Shen L, Shimizu Y, Sano T, Yamao K, Natsume A, Goto Y, Ito M, Murakami H, Osada H, Zhang J, Issa JPJ, Sekido Y. Variable DNA methylation patterns associated with progression of disease in hepatocellular carcinomas. Carcinogenesis. 2008 ; 29 : 1901-10 . PMID:18632756.
• Boumber YA, Kondo Y, Chen X, Shen L, Guo Y, Tellez C, Estécio MR, Ahmed S, Issa JPJ. An Sp1/Sp3 binding polymorphism confers methylation protection. PLoS Genet. 2008 ; 4 : e1000162 . PMID:18725933.
• Suehiro Y, Wong CW, Chirieac LR, Kondo Y, Shen L, Webb CR, Chan YW, Chan AS, Chan TL, Wu TT, Rashid A, Hamanaka Y, Hinoda Y, Shannon RL, Wang X, Morris J, Issa JPJ, Yuen ST, Leung SY, Hamilton SR. Epigenetic-Genetic Interactions in the APC/WNT, RAS/RAF, and P53 Pathways in Colorectal Carcinoma. Clin Cancer Res. 2008 ; 14 : 2560-9 . PMID:18451217.
• Osada H, Tomida S, Yatabe Y, Tatematsu Y, Takeuchi T, Murakami H, Kondo Y, Sekido Y, Takahashi T. Roles of ASH1 in DKK1 and E-cadherin repression and neuroendocrine differentiation in lung cancer. Cancer Res. 2008 ; 68 : 1647-55 . PMID:18339843.
• Natsume A, Wakabayashi T, Tsujimura K, Shimato S, Ito M, Kuzushima K, Kondo Y, Sekido Y, Kawatsura H, Narita Y, Yoshida J. The DNA demethylating agent 5-aza-2'-deoxycytidine activates NY-ESO-1 antigenicity in orthotopic human glioma. Int J Cancer. 2008 ; 122 : 2542-53 . PMID:18240144.
• Kondo Y, Shen L, Cheng A, Ahmed S, Boumber Y, Charo C, Yamochi T, Urano T, Furukawa K, Kwabi-Addo B, Gold D, Sekido Y, Huang T, Issa JPJ. Gene silencing in cancer by histone H3 lysine 27 trimethylation independent of promoter DNA methylation. Nat Genet. 2008 ; 40 : 741-50 . PMID:18488029.
• Kondo Y, Shen L, Ahmed S, Boumber Y, Sekido Y, Haddad BR, Issa JPJ. Downregulation of histone H3 lysine 9 methyltransferase G9a induces centrosome disruption and chromosome instability in cancer cells. PLoS One. 2008 ; 3 : e2037 . PMID:18446223.

2007年

• Kondo Y, Shen L, Suzuki S, Kurokawa T, Masuko K, Tanaka Y, Kato H, Mizuno Y, Yokoe M, Sugauchi F, Hirashima H, Orito E Osada H, Ueda R, Guo Y, Chen X, Issa JPJ, Sekido Y. Alterations of DNA methylation and histone modifications contribute to gene silencing in hepatocellular carcinomas. Hepatol Res. 2007 ; 37 : 974-83 . PMID:17584191.
• Tabe Y, Konopleva M, Kondo Y, Contractor R, Tsao T, Konoplev S, Shi Y, Ling X, Watt JC, Tsutsumi-Ishii Y, Ohsaka A, Nagaoka I, Issa JPJ, Kogan SC, Andreeff M. PPARγ -active triterpenoid CDDO enhances ATRA-induced differentiation in APL. Cancer Biol Ther. 2007 ; 6 : 1967-77 . PMID:18075297.
• Shen L, Kondo Y, Guo Y, Zhang J, Zhang L, Ahmed S, Shu J, Chen X, Waterland RA, Issa JPJ. Genome-wide profiling of DNA methylation reveals a class of normally methylated CpG island promoters. PLoS Genet. 2007 ; 3 : 2023-36 . PMID:17967063.
• Shen L, Kondo Y, Ahmed S, Boumber Y, Konishi K, Guo Y, Chen X, Vilaythong JN, Issa JPJ. Drug sensitivity prediction by CpG island methylation profile in the NCI-60 cancer cell line panel. Cancer Res. 2007 ; 67 : 11335-43 . PMID:18056460.
• Shen L, Toyota M, Kondo Y, Lin E, Zhang L, Guo Y, Hernandez NS, Chen X, Ahmed S, Konishi K, Hamilton SR, Issa JPJ. Integrated genetic and epigenetic analysis identifies three different subclasses of colon cancer. Proc Natl Acad Sci U S A. 2007 ; 104 : 18654-9 . PMID:18003927.
• Watanabe Y, Toyota M, Kondo Y, Suzuki H, Imai T, Ohe-Toyota M, Maruyama R, Nojima M, Sasaki Y, Sekido Y, Hiratsuka H, Shinomura Y, Imai K, Itoh F, Tokino T. PRDM5 identified as a target of epigenetic silencing in colorectal and gastric cancer. Clin Cancer Res. 2007 ; 13 : 4786-94 . PMID: 17699856.
• Boumber YA, Kondo Y, Chen X, Shen L, Gharibyan V, Konishi K, Estey E, Kantarjian H, Garcia-Manero G, Issa JPJ. RIL, a LIM gene on 5q31, is silenced by methylation in cancer and sensitizes cancer cells to apoptosis. Cancer Res. 2007 ; 67 : 1997-2005 .17332327.
• Sato N, Fukui T, Taniguchi T, Yokoyama T, Kondo M, Nagasaka T, Goto Y, Gao W, Ueda Y, Yokoi K, Minna JD, Osada H, Kondo Y, Sekido Y. RhoB is frequently downregulated in nonsmall-cell lung cancer and resides in the 2p24 homozygous deletion region of a lung cancer cell line. Int. J. Cancer. 2007 ; 120 : 543-51 . PMID:17096327.

2006年

• Tabe Y, Konopleva M, Kondo Y, Contractor R, Jin L, Ruvolo V, Tsutsumi-Ishii Y, Miyake K, Miyake N, Ohsaka A, Nagaoka I, Issa JPJ, Andreeff M. PML-RARα and AML1-ETO translocations are rarely associated with methylation of the RARβ2 promoter. Ann Hematol. 2006 ; 85 : 689-704 . PMID:16832676.

2005年

• Shen L, Kondo Y, Rosner GL, Xiao L, Hernandez NS, Vilaythong J, Houlihan PS, Krouse RS, Prasad AR, Einspahr JG, Buckmeier J, Alberts DS, Hamilton SR, Issa JPJ. MGMT promoter methylation and the field defect in sporadic colorectal cancer. J Natl Cancer Inst. 2005 ; 97 : 1330-8 . PMID:16174854.

2004年

• Kondo Y, Shen L, Yan PS, Huang TH, Issa JP. Chromatin immunoprecipitation microarrays for identification of genes silenced by histone H3 lysine 9 methylation. Proc Natl Acad Sci U S A. 2004 ; 101 : 7398-403 . PMID:15123805.
• Yang AS, Estecio M, Doshi K, Kondo Y, Tajara EH, Issa JPJ. A simple method for assessing global DNA methylation using bisulfite PCR of repetitive DNA elements. Nucleic Acids Res. 2004 ; 32 : e38 . PMID:14973332.
• Youssef EM, Chen XQ, Higuchi E, Kondo Y, Garcia-Manero G, Lotan R, Issa JPJ. Hypermethylation and silencing of the putative tumor suppressor (TIG-1) in human cancers. Cancer Res. 2004 ; 64 : 2411-7 . PMID:15059893.

2003年

• Kondo Y, Issa JPJ. Enrichment for histone H3 lysine 9 methylation at Alu repeats in human cells. J Biol Chem. 2003 ; 278 : 27658-62 . PMID:12724318.
• Kondo Y, Shen L, Issa JPJ. Critical role of histone methylation in tumor suppressor gene silencing in colorectal cancer. Mol Cell Biol. 2003 ; 23 : 206-15 . PMID:12482974.
• Suzuki S, Kondo Y, Hirashima N, Kato H, Sugauchi F, Orito E, Yang Y, Shen Y, Sakakibara K, Ueda R, Mizokami M. Evaluation of loss of heterozygosity before and after interferon therapy in patients with hepatitis C virus infection who developed hepatocellular carcinoma during follow up. J Gastroenterol Hepatol. 2003 ; 18 : 1364-72 . PMID:14675264.
• Shen L, Kondo Y, Hamilton SR, Rashid A, Issa JPJ. P14 methylation in human colon cancer is associated with microsatellite instability and wild-type p53. Gastroenterology. 2003 ; 124 : 626-33 . PMID:12612901.
• Fujii S, Luo RZ, Yuan J, Kadota M, Oshimura M, Dent SR, Kondo Y, Issa JPJ, Bast RC Jr, Yu Y. Reactivation of the silenced and imprinted alleles of ARHI is associated with increased histone H3 acetylation and decreased histone H3 lysine 9 methylation. Hum Mol Genet. 2003 ; 12 : 1791-800 . PMID:12874100.
• Shen L, Toyota M, Kondo Y, Obata T, Daniel S, Pierce S, Imai K, Kantarjian HM, Issa JPJ, Garcia-Manero G. Aberrant DNA methylation of p57KIP2 identifies a cell-cycle regulatory pathway with prognostic impact in adult acute lymphocytic leukemia. Blood. 2003 ; 101 : 4131-6 . PMID:12586619.

2002年

• Shen L, Kondo Y, Issa JPJ, Garcia-Manero G. Lack of p21 (CIP1) DNA methylation in acute lymphocytic leukemia. Blood. 2002 ; 100 : 3432-3 . PMID:12412576.

2001年

• Kanai Y, Ushijima S, Kondo Y, Nakanishi Y, Hirohashi S. DNA methyltransferase expression and DNA methylation of CPG islands and peri-centromeric satellite regions in human colorectal and stomach cancers. Int J Cancer. 2001 ; 91 : 205-12 . PMID:11146446.

2000年

• Zhu X, Kanai Y, Saito A, Kondo Y, Hirohashi S. Aberrant expression of β-catenin and mutation of exon 3 of the β-catenin gene in renal and urothelial carcinomas. Pathol Int. 2000 ; 50 : 945-52 . PMID:11123760.
• Kondo Y, Kanai Y, Sakamoto M, Mizokami M, Ueda R, Hirohashi S. Genetic instability and aberrant DNA methylation in chronic hepatitis and cirrhosis-A comprehensive study of loss of heterozygosity and microsatellite instability at 39 loci and DNA hypermethylation on 8 CpG islands in microdissected specimens from patients with hepatocellular carcinoma. Hepatology. 2000 ; 32 : 970-9 . PMID:11050047.

1999年

• Kondo Y, Kanai Y, Sakamoto M, Mizokami M, Ueda R, Hirohashi S. Microsatellite instability associated with hepatocarcinogenesis, J Hepatol. 1999 ; 31 : 529-36 . PMID:10488714.
• Kondo Y, Kanai Y, Sakamoto M, Genda T, Mizokami M, Ueda R, Hirohashi S. β-catenin accumulation and mutation of exon 3 of the β-catenin gene in hepatocellular carcinoma. Jpn J Cancer Res. 1999 ; 90 : 1301-9 . PMID:10665646.
• Nakano T, Park YM, Mizokami M, Choi JY, Orito E, Ohno T, Kato T, Kondo Y, Tanaka Y, Kato H, Kato T, Kim BS. TT virus infection among blood donors and patients with non-B, non-C liver diseases in Korea. J Hepatol. 1999 ; 30 : 389-93 . PMID:10190719.
• Kato H, Mizokami M, Nakano T, Kondo Y, Dashnyam B, Oyunsuren T, Ueda R. High prevalence and phylogenetic analysis of TT-virus infection in Mongolia. Virus Res. 1999 ; 60 : 171-9 . PMID:10392725.
• Kato T, Mizokami M, Orito E, Ohba K, Nakano T, Kondo Y, Tanaka Y, Ueda R, Mukaide M, Yasuda K, Iino S. Amino acid substitutions in NS5A region of GB virus C and response to interferon therapy. J Med Virol. 1999 ; 57 : 376-82 . PMID:10089050.

1998年

• Suzuki K, Mizokami M, Sale MG, Kondo Y, Hattori K, Kun C, Tibbs CJ, Williams R. GB virus C/hepatitis G virus infection in patients with chronic hepatitis C virus infection. Hepatol Res. 1998 , 11 : 95-102 .
• Kondo Y, Mizokami M, Nakano T, Kato T, Ohba K, Orito E, Tanaka Y, Hirashima N, Ueda R, Kunimatsu M, Sasaki M, Yasuda K, Shiro S. Analysis of conserved ambisense sequences within GB virus C. J Infect Dis. 1998 ; 178 : 1185-8 . PMID:9806057.
• Tanaka Y, Mizokami M, Orito E, Ohba K, Kato T, Kondo Y, Mboudjeka I, Zekeng L, Kaptue L, Bikandou B, M'Pele P,Takehisa J, Hayami M, Suzuki Y, Gojobori T. African origin of GB virus C/hepatitis G virus. FEBS Lett. 1998 ; 423 : 143-8 . PMID:9512347.
• Tanaka Y, Mizokami M, Orito E, Ohba K, Nakano T, Kato T, Kondo Y, Ding X, Ueda R, Sonoda S, Tajima K, Miura T, Hayami M. GB virus C/hepatitis G virus infection among Colombian native Indians. Am J Trop Med Hyg. 1998 ; 59 : 462-7 . PMID:9749645.
• Kato T, Mizokami M, Nakano T, Orito E, Ohba K, Kondo Y, Tanaka Y, Ueda R, Mukaide M, Fujita K, Yasuda K, Iino S. Heterogeneity in E2 region of GBV-C/hepatitis G virus and hepatitis C virus. J Med Virol. 1998 ; 55 : 109-17 . PMID: 9598930.

1997年

• Nakano T, Mizokami M, Orito E, Ohba K, Kondo Y, Kato T, Tanaka Y, Wakita A, Komatsu H, Nitta M, Ueda R. GB virus C/hepatitis G virus infection among Japanese patients with hematological diseases. Hepatol Res. 1997 ; 9 : 180-91 .
• Kondo Y, Mizokami M, Nakano T, Kato T, Ueda R, Mukaide M, Hikiji K, Ishida I, Dorjsuren D, Dashnyam B, Oyunsuren T. Prevalence and molecular epidemiology of GB virus C/hepatitis G virus infection in Mongolia. J Med Virol. 1997 ; 52 : 143-8 . PMID:9179759.
• Kondo Y, Mizokami M, Nakano T, Kato T, Ohba K, Orito E, Ueda R, Mukaide M, Hikiji K, Oyunsuren T, Cooksley W.G. Genotype of GB virus C/hepatitis G virus by molecular evolutionary analysis. Virus Res. 1997 ; 52 : 221-30 . PMID:9495537.
• Orito E, Mizokami M, Yasuda K, Sugihara K, Nakamura M, Mukaide M, Ohba K, Nakano T, Kato T, Kondo Y, Kumada T, Ueda R, Iino S. Interferon-α therapy in patients dually infected with hepatitis C virus and GB virusC/hepatitis G virus- virological response of HGV and pretreatment HGV viremia level. J Hepatol. 1997 ; 27 : 603-12 . PMID:9365035.
• Kato T, Mizokami M, Nakano T, Kondo Y, Ohba K, Orito E, Ueda R, Mukaide M, Gurtsevitch V, Syrtsev A, Ruzibakiev R, Abdurakhnamov M, Yamashita M, Hayami M. High prevalence of GB virus C/hepatitis G virus infection among the Jewish population in Uzbekistan. Virus Res. 1997 ; 48 : 81-7 . PMID: 9140196.