概要

当研究室では、体に負担が少なく精度の高い新しい画像診断法の開発や既存の技術の新たな分野への応用を目指して研究を行っています 。特に、被曝のないMRI装置を用いた先進的なイメージング技術を用いた研究に注力しています。

研究プロジェクト

1. 先進的イメージングによる新たながん診断法の開発

非侵襲的な拡散MRIをはじめとする様々な画像技術を用い、特に乳腺領域を専門とし、新たながん診断法の開発に取り組んでいます。本研究の目的は、画像から得られる多彩な情報が、微細な組織構造といった腫瘍の生物学的な特徴をいかに反映するかを解明することです。そのために、体内の水分子の動きからがん組織特有の構造を評価する拡散MRIにおいて、基本的なADC値の解析に加え、灌流を反映するIVIMや組織の複雑性を示す非ガウス拡散、拡散時間を変化させる手法など、先進的な解析を多角的に行っています。さらに、AIを用いてこれらの画像情報を統合し、臨床現場で医師を支援する半自動化された画像診断支援システムの開発も進めています。より精度の高いがん診断を実現し、最終的には患者さん一人ひとりに最適な治療法を選択するための一助となることを目指しています。

2. 4D Flow MRIによる血流動態解析と血管病変の解明

１．研究の背景・意義
心疾患、肺動脈疾患、動脈瘤、動脈解離、閉塞性動脈硬化症、など全身血管の病変の発生やその後の進行に血流動態が重要な因子であると考えられています。健常人や患者の個々の血流動態を正確に解析できれば、将来の病変の発生、その後の病気の進行状態が推定可能となり、予防や治療計画に役立つと考えられます。今までヒト血管の血流動態をin-vivoで３次元的に解析する方法は存在しなかったのですが、私共は10年ほど前に、スタンフォード大学とで開発された３次元シネ位相コントラスト磁気共鳴画像法（以下4DFLOW）を使用する機会を得て、それまで描出できなかった３次元血流情報を可視化して、今までに無い生理学情報を得て診療への応用を模索しております。最近になって、ウイスコンシン大学や、GEヘルスケア社、Siemens社、philips社などの大手医療機器メーカーも4DFLOWの製品開発に向けて注力しており、臨床現場では本技術の普及前夜といった状態であります。

２．研究の目的
私共の研究の当面の目的は磁気共鳴血管撮影所見（MR angiography; MRA）と３次元シネ位相コントラスト磁気共鳴画像法で求めた血流速度ベクトル、並びにこれから派生する壁剪断応力などのパラメータを病的血管と非病的血管で比較し、更に、患者と健常人で比較し、これにより、血行動態の異常と血管病変との関係を明らかにします。また、上記の磁気共鳴画像を用いた血流解析、血管モデルを使用したインビトロの血流解析、コンピュータを用いたシミュレーションによる血流解析（computational fluid dynamics、CFD、計算力学的流体解析）との比較検討も試みています。

腹部大動脈瘤の流線図（収縮期）　　　　　　　　　　　　剪断応力マップ

図の説明
流線図では非拡張部では血流は層流であるが、瘤内では乱流を生じているのがわかる。乱流により、同部の壁剪断応力は低下し、血管内皮はそれを感知して壁にatherogenic driveをかけ、ますます同部の壁は脆弱化し、瘤径増大、破裂へと向かうと推測される。

教員

研究実績

• 2025年

  1. Iima M, Mizuno R, Kataoka M, Tsuji K, Yamazaki T, Minami A, Honda M, Imanishi K, Takada M, Nakamoto Y. Deep Learning Applied to Diffusion-weighted Imaging for Differentiating Malignant from Benign Breast Tumors without Lesion Segmentation. Radiology: Artificial Intelligence. 2025; 7(1).
  2. Honda M, Kataoka M, Iima M, Ota R, Okazawa A, Fukushima Y, Nickel M. D., Sato F., Masuda N, Okada T, Nakamoto Y. Institutional Variability in Ultrafast Breast MR Imaging: Comparing Compressed Sensing and View Sharing Techniques with Different Patient Populations and Contrast Injection Protocols. Magn Reson Med Sci. 2025 Feb 8. doi: 10.2463/mrms.mp.2024-0152.
  3. Basukala D, Mikheev A, Li X., Goldberg J. D, Gilani N, Moy L, Pinker K, Partridge S. C, Biswas D, Kataoka M, Honda M, Iima M, Thakur S. B, Sigmund E. E. Retrospective BReast Intravoxel Incoherent Motion Multisite (BRIMM) multisoftware study. Front Oncol. 2025 Feb 24:15:1524634. doi: 10.3389/fonc.2025.1524634.
  4. Kataoka M, Iima M. Time to Consider Diffusion Time: Exploring the Potential of Time-Dependent Diffusion MRI in Breast Cancer Imaging. Radiology: Imaging Cancer. 2025;7(3):e250129.

• 2024年

  1. Tanaka H, Koyasu S, Kikuchi M, Iima M, Omori K, Nakamoto Y. Utility of Diffusion-weighted MR Imaging for Evaluating the Depth of Invasion in Oral Tongue Squamous Cell Carcinoma. Magn Reson Med Sci. 2024;24(2):210-219.
  2. Someya Y, Iima M, Imai H, Isoda H, Ohno T, Kataoka M, Le Bihan D, Nakamoto Y. In Vivo and Post-mortem Comparisons of IVIM/Time-dependent Diffusion MR Imaging Parameters in Melanoma and Breast Cancer Xenograft Models. Magn Reson Med Sci. 2025 Jul 31;24(4). doi: 10.2463/mrms.mp.2023-0078.
  3. Iima M, Nakayama R, Kataoka M, Otikovs M, Nissan N, Frydman L, Urushibata Y, Honda M, Okazawa A, Satake H, Naganawa S, Nakamoto Y. Comparing Lesion Conspicuity and ADC Reliability in High-resolution Diffusion-weighted Imaging of the Breast. Magn Reson Med Sci. 2024 Sep 26. doi: 10.2463/mrms.tn.2024-0089.
  4. Sugimoto M, Horiguchi R, Ikeda S, Kawai Y, Niimi K, Hyodo R, Banno H. The immediate post-operative impact of infrarenal aortic endografts on renal arterial flow dynamics: Insights from four-dimensional flow magnetic resonance imaging analysis. Vascular. 2024;23:17085381241277651.
  5. Hyodo R, Takehara Y, Ishizu Y, Nishida K, Mizuno T, Ichikawa K, Horiguchi R, Kurata N, Ogura Y, Yokoyama S, Naganawa S, Jin N, Ichiba Y. Evaluation of 4D Flow MRI-Derived Relative Residence Time as a Marker for Cirrhosis Associated Portal Vein Thrombosis. J Magn Reson Imaging. 2024;60:2592-2601.
  6. Takehara Y, Hyodo R. Editorial for \"Comparative Performance of 2018 LI-RADS versus Modified LIRADS (mLI-RADS): An Individual Participant Data Meta-Analysis\". Journal of Magnetic Resonance Imaging 2024;60:1092-1093.
  7. Iima M, Kataoka M, Honda M, Le Bihan D. Diffusion-Weighted MRI for the Assessment of Molecular Prognostic Biomarkers in Breast Cancer. Korean journal of radiology. 2024;25(7):623-633.
  8. Honda M, Sigmund E, Le Bihan D, Pinker K, Clauser P, Karampinos D, Partridge S, Fallenberg E, Martincich L, Baltzer P, Mann R, Camps-Herrero J., Iima M. Advanced breast diffusion-weighted imaging: what are the next steps? A proposal from the EUSOBI International Breast Diffusion-weighted Imaging working group. European Radiology. 2024;35(4):2130-2140.
  9. Iima M, Honda M, Satake H, Kataoka M. Standardization and advancements efforts in breast diffusion-weighted imaging. Japanese Journal of Radiology. 2024;43(3):347-354.
  10. Minami A, Mizuno R, Kataoka M, Iima M. Comments on “A Channel‐Dimensional Feature‐Reconstructed Deep Learning Model for Predicting Breast Cancer Molecular Subtypes on Overall b‐Value Diffusion‐Weighted MRI”. Journal of Magnetic Resonance Imaging. 2024; 60(5):2237-2238.
  11. Kataoka M, Iima M. Potential of the Diffusion-based Noncontrast Protocol for Breast Imaging: Current Status and Hints for Improvements. Radiology. 2024;311(2):e241058.
  12. Honda M, Iima M. It Is Time to Use Apparent Diffusion Coefficient in Breast MRI Diagnostics. Radiology. 2024;310(2):e24901.
  13. Iima M, Miki Y, Naganawa S. 40 years of diffusion MRI: a journey from basic science to clinical breakthrough. Japanese Journal of Radiology. 2024;42(2):1355-1356.

• 2023年

  1. Hyodo R, Takehara Y, Mizuno T, Ichikawa K, Horiguchi R, Kawakatsu S, Mizuno T, Ebata T, Naganawa S, Jin N, Ichiba Y. Four-dimensional Flow MRI Assessment of Portal Hemodynamics and Hepatic Regeneration after Portal Vein Embolization. Radiology. 2023 Sep;308(3):e230709. doi: 10.1148/radiol.230709.
  2. Horiguchi R, Takehara Y, Sugiyama M, Hyodo R, Komada T, Matsushima M, Naganawa S, Mizuno T, Sakurai Y, Sugimoto M, Banno H, Komori K, Itatani K. Postendovascular Aneurysmal Repair Increase in Local Energy Loss for Fusiform Abdominal Aortic Aneurysm: Assessments With 4D flow MRI. J Magn Reson Imaging. 2023;57:1199-1211.

• 2022年

  1. de Boer A, Villa G, Bane O, Bock M, Cox EF, Dekkers IA, Eckerbom P, Fernández-Seara MA, Francis ST, Haddock B, Hall ME, Hall Barrientos P, Hermann I, Hockings PD, Lamb HJ, Laustsen C, Lim RP, Morris DM, Ringgaard S, Serai SD, Sharma K, Sourbron S, Takehara Y, Wentland AL, Wolf M, Zöllner FG, Nery F, Caroli A. Consensus-Based Technical Recommendations for Clinical Translation of Renal Phase Contrast MRI. J Magn Reson Imaging. 255(2):323-335. 2022 Feb
  2. Itatani K, Sekine T, Yamagishi M, Maeda Y, Higashitani N, Miyazaki S, Matsuda J, Takehara Y. Hemodynamic Parameters for Cardiovascular System in 4D Flow MRI: Mathematical Definition and Clinical Applications. Magn Reson Med Sci. 21(2):380-399. 2022 Mar 1
  3. Takehara Y, Sekine T, Obata T. Why 4D Flow MRI? Real Advantages. Magn Reson Med Sci. 21(2):253-256. 2022 Mar 1
  4. Sugiyama M, Takehara Y, Naganawa S. Does the Pulsatile Non-uniform Flow Matter in MR Flowmetry? Magn Reson Med Sci. 21(2):365-371. 2022 Mar 1
  5. Terada M, Takehara Y, Isoda H, Wakayama T, Nozaki A. Technical Background for 4D Flow MR Imaging. Magn Reson Med Sci. 21(2):267-277. 2022 Mar 1
  6. Takehara Y. Clinical Application of 4D Flow MR Imaging for the Abdominal Aorta. Magn Reson Med Sci. 21(2):354-364. 2022 Mar 1
  7. Hyodo R, Takehara Y, Naganawa S. 4D Flow MRI in the portal venous system: imaging and analysis methods, and clinical applications. Radiol Med. 2022;127:1181-1198.

• 2021年

  1. Suzuki K, Takehara Y, Sakata M, Kawate M, Ohishi N, Sugiyama K, Akai T, Suzuki Y, Sugiyama M, Kawamura T, Morita Y, Kikuchi H, Hiramatsu Y, Yamamoto M, Nasu H, Johnson K, Oliver Wieben, Kurachi K, Takeuchi H. Daikenchuto increases blood flow in the superior mesenteric artery in humans: A comparison study between four-dimensional phase-contrast vastly undersampled isotropic projection reconstruction magnetic resonance imaging and Doppler ultrasound. PLoS One. 16(1):e0245878. 2021 Jan 27
  2. Ryota Hyodo, Yasuo Takehara, Takashi Mizuno, Kazushige Ichikawa, Yasuhiro Ogura , Shinji Naganawa. Portal Vein Stenosis Following Liver Transplantation Hemodynamically Assessed with 4D-flow MRI before and after Portal Vein Stenting. Magn Reson Med Sci. 20(3):231-235. 2021 Sep 1
  3. Ryota Horiguchi, Hiroshi Ogawa, Naoya Nagai, Yasuo Takehara, Shinji Naganawa. Yukihiro Yokoyama, Yoshie Shimoyama. A case of intraductal tubulopapillary neoplasm of the pancreas originating from the branch duct: cast in the mold sign. Nagoya J Med Sci. 83(4):869-875. 2021 Nov
  4. Takahashi M, Takehara Y, Fujisaki K, Okuaki T, Fukuma Y, Tooyama N, Ichijo K, Amano T, Goshima S, Naganawa S. Three Dimensional Ultra-short Echo Time MRI Can Depict Cholesterol Components of Gallstones Bright. Magn Reson Med Sci. 20(4):359-370. 2021 Dec 1
  5. Hyodo R, Takehara Y, Nishida A, Matsushima M, Naganawa S. “Speckled Enhancement” on Gd-EOB-DTPA Enhanced MR Imaging of Primary Hepatic Mucosa-associated Lymphoid Tissue Lymphoma. Magn Reson Med Sci. doi: 10.2463/mrms.mp.2021-0069. 2021 Oct 7
  6. Inoue J, Matsuo K, Iwabuchi T, Takehara Y, Yamasue H. How Memory Switches Brain Responses of Patients with Post-traumatic Stress Disorder. Cereb Cortex Commun. 2(2):tgab021. 2021 Mar 20
  7. Hyodo R, Takehara Y, Mizuno T, Ichikawa K, Yokoyama S, Ishizu Y, Naganawa S. Assessing the Complicated Venous Hemodynamics and Therapeutic Outcomes of Budd-Chiari Syndrome with Respiratory-gated 4D Flow MR Imaging During the Expiratory and Inspiratory Phases. Magn Reson Med Sci. 22(1):1-6. doi: 10.2463/mrms.ici.2021-0110.
  8. Miyajima K, Urushida T, Ito K, Kin F, Okazaki A, Takashima Y, Watanabe T, Kawaguchi Y, Wakabayashi Y, Takehara Y, Maekawa Y. Four-dimensional flow magnetic resonance imaging visualizes reverse vortex pattern and energy loss increase in left bundle branch block. Europace. euab299. doi: 10.1093/europace/euab299. 2021 Dec 17
  9. Hyodo R, Takehara Y, Mizuno T, Ichikawa K, Ishizu Y, Sugiyama M, Naganawa S. Time-resolved 3D cine phase-contrast magnetic resonance imaging (4D-flow MRI) can quantitatively assess portosystemic shunt severity and confirm normalization of portal flow after embolization of large portosystemic shunts. Hepatol Res. 51(3):343-349. 2021 Mar
  10. Ogawa H, Takehara Y, Naganawa S. Imaging diagnosis of autoimmune pancreatitis: computed tomography and magnetic resonance imaging. J Med Ultrason (2001) 48(4):565-571. 2021 Oct

• 2020年

  1. Perera R, Isoda H, Ishiguro K, Mizuno T, Takehara Y, Terada M, Tanoi C, Naito T, Sakahara H, Hiramatsu H, Namba H, Izumi T, Wakabayashi T, Kosugi T, Onishi Y, Alley M, Komori Y, Ikeda M, Naganawa S. Assessing the Risk of Intracranial Aneurysm Rupture Using Morphological and Hemodynamic Biomarkers Evaluated from Magnetic Resonance Fluid Dynamics and Computational Fluid Dynamics. Magn Reson Med Sci. 19(4):333-344. 2020 Dec 1
  2. Sugiyama M, Takehara Y, Kawate M, Ooishi N, Terada M, Isoda H, Sakahara H, Naganawa S, Kevin M. Johnson, Oliver Wieben, Wakayama T, Nozaki A, Kabasawa H. Optimal Plane Selection for Measuring Post-prandial Blood Flow Increase within the Superior Mesenteric Artery: Analysis Using 4D Flow and Computational Fluid Dynamics. Magn Reson Med Sci. 19(4):366-374. 2020 Dec 1
  3. Umakoshi H, Nihashi T, Shimamoto H, Yamada T, Ishiguchi H, Takada A, Hirasawa N, Ishihara S, Takehara Y, Naganawa S, Matthew Davenport, Terasawa T. Pharmacologic and non-pharmacologic interventions to prevent hypersensitivity reactions of non-ionic iodinated contrast media: a systematic review protocol. BMJ Open. 10(3):e033023. 2020 Mar 9
  4. Takehara Y, Isoda H, Takahashi M, Unno N, Shiiya N, Ushio T, Goshima S, Naganawa S, Marcus Alley, Wakayama T, Nozaki A. Abnormal Flow Dynamics Result in Low Wall Shear Stress and High Oscillatory Shear Index in Abdominal Aortic Dilatation: Initial in vivo Assessment with 4D-flow MRI. Magn Reson Med Sci. 19(3):235-246. 2020 Aug 3
  5. Karayama M, Yoshizawa N, Sugiyama M, Mori K, Yasui H, Hozumi H, Suzuki Y, Furuhashi K, Fujisawa T, Enomoto N, Nakamura Y, Inui N, Goshima S, Suda T, Takehara Y. Intravoxel incoherent motion magnetic resonance imaging for predicting the long-term efficacy of immune checkpoint inhibitors in patients with non-small-cell lung cancer. Lung Cancer. 143:47-54. 2020 May
  6. Takehara Y. 4D Flow when and how? Radiol Med. 125 (9) 838-850. 2020
  7. Motosugi U, Takehara Y. Motion and solution in hepatobiliary agent-enhanced dynamic MRI: solid evidence and unanswered question. Jpn J Radiol. 38(2):99-100. 2020 Feb

• 2019年

  1. Ogawa H, Takehara Y, Naganawa S, Yamaguchi J, Nakaguro M. A case of human pancreatic eurytremiasis. Abdom Radiol (NY). 44(4):1213-1216. 2019 Apr.
  2. Katahashi K, Sano M, Takehara Y, Inuzuka K, Sugiyama M, Alley MT, Takeuchi H, Unno N. Flow dynamics of type II endoleaks can determine sac expansion after endovascular aneurysm repair using four-dimensional flow-sensitive magnetic resonance imaging analysis. J Vasc Surg. 70(1):107-116.e1. 2019 Jul
  3. Watanabe T, Isoda H, Fukuyama A, Takahashi M, Amano T, Takehara Y, Oishi N, Kawate M, Terada M, Kosugi T, Komori Y, Fukuma Y, Alley M. Accuracy of the Flow Velocity and Three-directional Velocity Profile Measured with Three-dimensional Cine Phase-contrast MR Imaging: Verification on Scanners from Different Manufacturers. Magn Reson Med Sci. 18(4):265-271. 2019 Oct 15
  4. Uchida W, Tokuda Y, Takehara Y, Usui A. Mechanical haemolytic anaemia assessed with four-dlmenslonal flow cardiac magnetic resonance. Eur J Cardiothorac Surg. 56(4):813-814. 2019 Oct 1

• 2018年

  1. Watanabe T, Isoda H, Takehara Y, Terada M, Naito T, Kosugi T, Onishi Y, Tanoi C, Izumi T. Hemodynamic vascular biomarkers for initiation of paraclinoid internal carotid artery aneurysms using patient-specific computational fluid dynamic simulation based on magnetic resonance imaging. Neuroradiology. 2018 Mar 8.

• 2017年

  1. Miyazaki S, Itatani K, Furusawa T, Nishino T, Sugiyama M, Takehara Y, Yasukochi S. Validation of numerical simulation methods in aortic arch using 4D Flow MRI. Heart Vessels. 2017 Aug;32(8):1032-1044.
  2. Motoyama D, Ishii Y, Takehara Y, Sugiyama M, Yang W, Nasu H, Ushio T, Hirose Y, Ohishi N, Wakayama T, Kabasawa H, Johnson K, Wieben O, Sakahara H, Ozono S.Four-dimensional phase-contrast vastly undersampled isotropic projection reconstruction (4D PC-VIPR) MR evaluation of the renal arteries in transplant recipients: Preliminary results. J Magn Reson Imaging. 2017 Aug;46(2):595-603.
  3. Natsume K, Shiiya N, Takehara Y, Sugiyama M, Satoh H, Yamashita K, Washiyama N. Characterizing saccular aortic arch aneurysms from the geometry-flow dynamics relationship. J Thorac Cardiovasc Surg. 2017 Jun;153(6):1413-1420.

• 2016年

  1. Suwa K, Saitoh T, Takehara Y, Sano M, Saotome M, Urushida T, Katoh H, Satoh H,Sugiyama M, Wakayama T, Alley M, Sakahara H, Hayashi H. Intra-left ventricular flow dynamics in patients with preserved and impaired left ventricular function: Analysis with 3D cine phase contrast MRI (4D-Flow). J Magn Reson Imaging. 2016 Dec;44(6):1493-1503.
  2. Yoshizawa N, Ueda Y, Nasu H, Ogura H, Ohmae E, Yoshimoto K, Takehara Y,Yamashita Y, Sakahara H. Effect of the chest wall on the measurement of hemoglobin concentrations by near-infrared time-resolved spectroscopy in normal breast and cancer. Breast Cancer. 2016 Nov;23(6):844-850.
  3. Odagiri K, Inui N, Hakamata A, Inoue Y, Suda T, Takehara Y, Sakahara H,Sugiyama M, Alley MT, Wakayama T, Watanabe H. Non-invasive evaluation of pulmonary arterial blood flow and wall shear stress in pulmonary arterial hypertension with 3D phase contrast magnetic resonance imaging. Springerplus.2016 Jul 13;5(1):1071.
  4. Sakata M, Takehara Y, Katahashi K, Sano M, Inuzuka K, Yamamoto N, Sugiyama M, Sakahara H, Wakayama T, Alley MT, Konno H, Unno N. Hemodynamic Analysis of Endoleaks After Endovascular Abdominal Aortic Aneurysm Repair by Using 4-Dimensional Flow-Sensitive Magnetic Resonance Imaging. Circ J. 2016 Jul 25;80(8):1715-25.
  5. Sakai N, Takehara Y, Yamashita S, Ohishi N, Kawaji H, Sameshima T, Baba S,Sakahara H, Namba H. Shear Stiffness of 4 Common Intracranial Tumors Measured Using MR Elastography: Comparison with Intraoperative Consistency Grading. AJNR Am J Neuroradiol. 2016 Jun 23. [Epub ahead of print]
  6. Sato Y, Nakahara K, Shimada M, Hara Y, Takayanagi D, Sawada N, Mukai S,Shimada S, Yamaguchi N, Hidaka E, Takehara Y, Ishida F, Kudo SE. Donor Left-Sided Heptectomy by Use of the Real-Time Moving Windows Method With 8-Centimeter Transverse Skin Incision. Transplant Proc. 2016 May;48(4):1083-6.
  7. Yoshihara S, Matsunaga M, Yaegashi T, Suzuki S, Naito M, Takehara Y. Unusual Serial Electrocardiographic Changes which Progressed to Arrhythmogenic Right Ventricular Cardiomyopathy. Intern Med. 2016;55(9):1103-8.
  8. Tsushima Y, Ishiguchi T, Murakami T, Hayashi H, Hayakawa K, Fukuda K, Korogi Y, Sugimoto H, Takehara Y, Narumi Y, Arai Y, Kuwatsuru R, Yoshimitsu K, Awai K,Kanematsu M, Takagi R. Safe use of iodinated and gadolinium-based contrast media in current practice in Japan: a questionnaire survey. Jpn J Radiol. 2016 Feb;34(2):130-9.
  9. Yamashita Y, Murayama S, Okada M, Watanabe Y, Kataoka M, Kaji Y, Imamura K, Takehara Y, Hayashi H, Ohno K, Awai K, Hirai T, Kojima K, Sakai S, Matsunaga N, Murakami T, Yoshimitsu K, Gabata T, Matsuzaki K, Tohno E, Kawahara Y, Nakayama T,Monzawa S, Takahashi S. The essence of the Japan Radiological Society/Japanese College of Radiology Imaging Guideline. Jpn J Radiol. 2016 Jan;34(1):43-79.
  10. Terada M, Takehara Y, Isoda H, Uto T, Matsunaga M, Alley M. Low WSS and High OSI Measured by 3D Cine PC MRI Reflect High Pulmonary Artery Pressures in Suspected Secondary Pulmonary Arterial Hypertension. Magn Reson Med Sci. 2016;15(2):193-202.

名古屋大学医学部放射線医学教室 (教室独自HP)