病態内科学消化器内科
研究室概要
当科は消化器のすべての疾患の診療を日本のトップレベルの知識と技術で行っています。医局員を消化管(上部、下部)、肝臓、胆膵の3グループに分け、臨床では上部、下部、胆膵グループは、主に新しい内視鏡診断・治療技術の導入と開発、肝臓グループではウイルス肝炎、肝硬変、肝癌の新規治療に取り組んでおります。また、研究では、各グループの研究に加えて、栄養あるいは腸内細菌の研究に関しては、小腸や大腸のみでなく膵臓、肝臓を含めた多臓器から取り組んでいます。このように当科では今までの伝統をさらに発展させた臨床・研究、あるいは新しく立ち上げた臨床・研究に若い医師が積極的に取り組んでいます。更にグローバル化の一つとして2012年よりメコン5か国(ベトナム)、ラオス、カンボジア、タイ、ミャンマー)での内視鏡技術向上のために、内視鏡トレーニングセンターなどを設立し国家プロジェクトとして貢献しておりますし、外国との共同研究も積極的に行っております。
研究プロジェクト
消化管グループ
上部消化管グループでは、現在咽喉頭から十二指腸までの消化管を対象とした診療・研究を行っています。診療では、消化管早期がんの内視鏡診断(NBI, BLI, 超拡大内視鏡, EUS)・治療(ELPS, EMR, ESD, EMRO, PDT, LECS)に力をいれています。また、現在までに下記の研究を行なっています。
AI関連
- ・食道・胃病変の指摘および診断に対する人工知能技術を用いたコンピュータ支援医用画像診断システムの開発。
- ・超音波内視鏡に対する人工知能を用いた上部消化管粘膜下腫瘍の画像診断支援システムの開発研究。
- ・Deep learningを用いた食道表在癌の深達度診断
腸内細菌関連
- ・ヘリコバクターピロリ菌除菌前後における腸内細菌叢の変化。
- ・消化管腫瘍患者における口腔内・腸内細菌叢の構成および機能の変化との関連。
- ・早期胃癌ESD症例に対するケストース療法による栄養状態および腸内細菌叢の変化。
ESD関連
- ・高齢者胃癌ESD後の長期予後に関連する患者因子の研究
- ・80歳以上の食道表在癌、早期胃癌患者に対する治療選択システムの確立(多施設共同試験)
- ・ESD適応の表在型食道扁平上皮癌患者に対して、経過観察例も含めて長期予後予測因子を同定することで、治療方針として「ESDを行わない、経過観察」という選択肢の可能性を探る研究。
- ・抗血栓薬内服症例における胃ESD後出血リスク因子の解析およびリスク低減のための工夫。
- ・十二指腸非乳頭部腫瘍に対する内視鏡治療の適応・治癒基準の検討および安全・確実なESD方法の開発。
診断法関連
- ・High resolution manometry (HRM)を用いた糖尿病性蠕動障害の頻度とその病態の解明。
- ・EUSおよびHRMを用いた好酸球性食道炎患者における自覚症状の客観的評価方法の研究。
- ・好酸球性食道炎に対する超拡大内視鏡を用いた食道好酸球増多や活動性の評価と、optical biopsyとしての有用性の検討。
- ・胃悪性リンパ腫の画像診断および適切なフォローアップ方法の確立。
- ・咽頭腫瘍、十二指腸乳頭部腫瘍に対する超拡大観察を用いた診断法の確立。
- ・十二指腸非乳頭部腫瘍に対する超拡大内視鏡を用いた観察における至適染色法の検討および良悪性鑑別のための診断基準の確立。
- ・十二指腸非乳頭部腫瘍に対する治療選択を見据えた白色光・画像強調内視鏡を用いた効率的な診断法の確立。
下部消化管領域(小腸・大腸)では臨床業務(研究)・基礎研究・臨床検体を用いた基礎的病態解析を柱として日々の診療を行っています。
1) 臨床研究
主に小腸疾患、炎症性腸疾患(IBD)、大腸腫瘍、機能性腸疾患などを対象とした研究を進めております。小腸は検査のしづらさから近年まで「暗黒大陸」と呼ばれていましたが、当院では小腸カプセル内視鏡・小腸バルーン内視鏡を開発当初より取り入れ、小腸疾患の内視鏡的な診断・managementに関して、様々な報告をしてきました。また、炎症性腸疾患では、小腸に対する検査を得意とすることの強みを生かして、クローン病の小腸病変に関する様々な報告をしています。炎症性腸疾患ではその他に、微量元素や亜鉛の欠乏と病態との相関も臨床研究をすすめています。
大腸腫瘍の内視鏡治療は、巨大病変、線維化症例、治療後再発症例、虫垂病変、UC関連腫瘍などの治療困難症例に対しても積極的に行っています。また、画像強調内視鏡やEUSを用いて診断精度の向上を目指した研究をしています。また、機能性腸疾患に対しては、新たな治療法の開発を目指し、FMT(糞便移植)そのほかの新規治療薬の効果を検証する臨床試験を行っています。また他施設との共同研究なども積極的に参加しています。
2) 臨床検体を用いた基礎的病態解析
早期大腸癌とIBD関連大腸癌の臨床病理学的・分子生物学的因子の検討を行っています。早期大腸癌ではESD治療後、一定の病理学的基準を満たさない場合はリンパ節転移のリスクを懸念して追加手術が推奨されますが、実際のリンパ節転移は低率であり、我々は新たなリスク因子の探索を目指しています。
また、IBD関連大腸癌は通常の大腸癌と異なるpathwayによる炎症性発癌とされていますが、病変自体が不明瞭で内視鏡による早期発見が困難な場合が多く、また通常の大腸癌と判別困難な場合もあります。我々は、大腸癌のESD検体や手術検体などを用いて、免疫組織化学染色による病理学的検討や、次世代シーケンサーによる遺伝子解析などを行い、早期発見に有用な因子や予後予測因子の検討を行っています。
3} 基礎研究
がん抑制性機能を有するがん抑制性線維芽細胞を特異的に標識するマーカー分子Meflinを世界に先駆けて同定しました。また、がんの進行に伴って、Meflin陽性線維芽細胞(善玉)が、Meflin陰性線維芽細胞(悪玉)に形質転換することも明らかにしました。 “悪玉”線維芽細胞を“善玉”線維芽細胞に戻す(形質転換させる)ことができれば、それはがんのみならず多くの疾患の治療法になることが期待されます。現在新規概念である線維芽細胞の形質転換療法を開発するための医師主導治験(対象:膵がん)を2021年から予定していますし、IBDへの応用も模索しています。
胆膵グループ
1) 超音波を用いた新しい胆道・膵臓疾患の診断法の開発
腹部超音波検査・超音波内視鏡検査(EUS)に超音波造影剤(当院IRBの承認すみ)やエラストグラフィ(strain法、shear wave法)、空間位置情報を加味したGPS機能、CT-fusion機能、3D超音波などの新しいモダリティーを積極的に導入し、最新の診断をおこなっています。また内視鏡下や超音波内視鏡下穿刺生検(EUS-FNA)下に得られた胆道・膵臓疾患の検体(組織や膵液など)を用いて分子生物学的な診断や治療に有用な結果を目指した研究をしています。


2) 切除不能膵癌に対する新たな治療方法の開発
予後の悪い切除不能膵癌に対する新たな治療法として腫瘍病理と協力して新たな治療法を開発、医師主導治験を目指しています。
3) 十二指腸乳頭部腫瘍の内視鏡診断と治療
内視鏡的逆行性胆管膵管造影(ERCP)や、管腔内超音波検査(IDUS)などを用いて十二指腸乳頭部腫瘍の進展範囲を詳細に診断し、より侵襲が少なく、偶発症の少ない内視鏡的乳頭切除術を施行しています。
4) 胆道疾患の経十二指腸乳頭的診断と治療
管腔内超音波検査(IDUS)、経乳頭的胆管生検などを積極的に施行し、より侵襲が少なく確実な診断を目指して研究しています。また、総胆管結石や閉塞性黄疸に対し、適切な切石法やドレナージ法を選択することにより低侵襲で確実な治療を施行しています。
5) 膵管内乳頭粘液性腫瘍(IPMN)をはじめとした膵嚢胞性疾患の診断法の開発、自然史解明への研究
造影超音波内視鏡や内視鏡的胆管膵管造影(ERCP)をはじめとした各種画像診断技術を駆使し、既存の診断法よりも侵襲が少なく確実な膵嚢胞の診断治療、開発を行っています。また膵嚢胞性疾患の経過観察を長期間行うことにより、膵嚢胞性疾患の自然史解明に向けた多施設共同研究を行っています。
6) 自己免疫性膵炎の診断・治療・自然史に関する研究
自己免疫性膵炎(AIP)はその発生に免疫学的機序が関与する特殊な膵炎です。AIPは膵癌との鑑別を要する画像所見を呈し、その診断において病理学的所見は重要な位置を占めます。名古屋大学ではAIPを疑う患者さんに対して超音波内視鏡下穿刺生検(EUS-FNA)を積極的に施行しています。得られた検体を詳細に解析し、AIP診断に対する、低侵襲かつ安全な組織学的診断法であるEUS-FNAの有用性を研究しています。またAIPはステロイド治療に反応し、短期予後は良好とされていますが、長期予後については不明な点が多く残されています。現在AIP症例を集積し、再燃の予測因子、内外分泌能の予後、悪性腫瘍の合併など長期的な臨床像の検討を行っています。


7) 栄養の消化吸収を担う、膵・小腸臓器相関、腸内細菌叢と病態の解明
改良型小腸内視鏡試作機を使用することで、低侵襲な近位小腸までの内視鏡観察が可能となりました。膵疾患例を中心に小腸絨毛形態および機能の評価を行い、消化吸収の主座となる膵と小腸の臓器相関について研究しています。また次世代シーケンサーを用いて、糞便などから得られた腸内細菌叢を解析し、種々の疾患・病態との相関を研究しています。
8) AIを用いたEUS診断
近年、消化器内視鏡画像を用いた人工知能(artificial intelligence;以下AI)での診断の有用性が報告されその動向が注目されています。一方、胆膵領域における超音波内視鏡(EUS)の進歩は目覚ましく、画質の向上は基より、組織の硬さを測定するEUSエラストグラフィ、血行動態を詳細に評価する造影EUS、EUS観察下に組織を採取するEUSガイド下穿刺生検などEUSを用いた様々な新規技術が登場し、胆膵疾患診療において、なくてはならない手技となっています。しかしながらEUSは主観性の高い検査であり、術者の技術や経験によるところも大きいという問題があります。現在、EUS診断の客観性、正確性を高めるため、工学系の研究者と協力してAI診断の研究をしています。
肝臓グループ
1)名古屋大学医学部消化器内科を中心とした肝臓病学多施設臨床研究グループの立ち上げ
名古屋大学消化器内科には約50の関連病院があり、これらの関連病院と共同で広く「肝疾患の病態解明とエビデンス構築」を目指した臨床研究グループを立ち上げることとしました。
2) ウイルス性肝炎における病態の解明
i) C型肝炎ウイルス(HCV) 現在当院を中心として、インターフェロン(IFN)ベース治療後の新たなフリーDirect Acting Antiviral(DAA)併用治療に関しての多施設共同研究を施行、治療効果、安全性、治療効果に関与する因子の探索的検討を施行しています。特に我々は現在までにIFNベース治療とIL28B宿主遺伝子多型、HCV core領域、NS5A領域と病態、および治療効果について明らかにしてきました。現在IFNフリー治療においてもこれらの検討、およびウイルス消失による免疫反応の動態解析も行っています。また、インターフェロンフリー治療により増加したSVR後の病態についても検討を行っています。
ii) B型肝炎ウイルス(HBV) HBVはHCVと比較して複雑な生活環を持ち宿主肝細胞の核内にcccDNAとして安定した形で存在するため、根治療法の開発が困難とされています。我々は現在、臨床的寛解状態と考えられるHBs抗原消失とHBV core領域の変異との関係、また現在標準治療として使用されている核酸アナログ製剤で血中HBV DNA陰性化が得られている症例において、血清マーカー(HBs抗原、HBコア関連抗原)の値と病態との関係、また発癌に関与する因子の検討などを行っています。
3) 急性肝不全動物モデルにおける炎症と再生の相関
肝不全に対して直接肝再生を促す確立された方法がない現状で、我々はそれを解決する方策の有力な候補の一つとして、口腔外科との共同研究で歯髄由来の幹細胞培養上清を用い、それを急性肝不全モデル動物に投与することで効果を示すことを明らかにしてきました。現在その培養上清中に強い効果を示す因子を同定し、その抗炎症作用、肝再生促進作用について検討し、肝再生には強力な抗炎症との相関が不可欠であることを見出すべく検討を進めています。
4)非アルコール性脂肪性肝疾患(NAFLD)/非アルコール性脂肪性肝炎(NASH)患者の予後の検討及び
動物モデルにおける各種治療薬の治療効果の検討
NAFLD、特に肝硬変・肝癌に至る可能性のあるNASHは増加の一途を辿っており、問題となっている。このようなNAFLD、NASH患者に関する特徴や予後の臨床的検討を行っています。を行っています。またNASH及びNASHベースの肝硬変や肝癌を発症するマウスモデルにおいて各種薬剤を投与することにより肝臓の炎症、線維化、脂肪蓄積などの改善、さらには発癌抑制効果や腸内細菌との関係について検討し、その機序を明らかにする研究を行っています。
5)肝疾患と腸内細菌叢の相関
各種肝疾患と腸内細菌叢の相関について、次世代シーケンサー(NGS)により腸内細菌叢を解析検討しています。特に、肝硬変及び肝癌における腸内細菌叢の特徴を明らかにする研究を行っています。プレバイオティクスによりNASH/NAFLDの改善をみる前向きの無作為比較試験も行っています。
6)サルコペニアと肝硬変の関連性
肝硬変患者において、サルコペニア(筋肉量、筋量が低下した状態)が予後不良因子であること、QOL増悪因子であることを明らかにしてきた。現在はサルコペニアに対する運動療法の開発を行い、肝硬変患者の予後延長に繋がるか検討を行っています。さらに基礎研究として、腸内細菌叢とサルコペニアに関する研究も行っています。
7)門脈圧亢進症に対する病態の評価および治療に関する解析
門脈圧亢進症は肝硬変に由来する代表的な合併症であり、それに伴う食道胃静脈瘤出血や腹水貯留などは患者の生命予後やQOLを悪化させる要因です。近年B型肝炎やC型肝炎に対する抗ウイルス療法は進歩していますが。高度に肝線維化が進展した症例や増加する非アルコール性脂肪性肝炎症例などの存在により、門脈圧亢進症のマネジメントは依然として肝疾患診療における重要な課題です。
8)免疫チェックポイント阻害薬による免疫関連有害事象
現在のがん治療の中心的薬剤の一つである免疫チェックポイント阻害薬による免疫関連有害事象(irAE)としての肝障害の発症メカニズムを解明し、その発症予測と効率的な治療アルゴリズムを開発することを目的として、バイオマーカー探索研究を行っております。
伊藤忠商事次世代がん治療研究講座
本講座は、産学協同研究講座として、令和元年6月1日に、新規がん治療法の開発を目指し、名古屋大学と伊藤忠商事株式会社により設置されました (設置期間:令和元年6月1日~令和4年9月30日)。
これまで、さまざまな抗がん剤を用いた治療法が開発されてきましたが、日本のみならず世界的に、いまだにがん (悪性新生物) による死亡率は高く、また、がんの制御が行えたとしても副作用で苦しむ患者さんも多く、身体にやさしい革新的ながん治療法への需要はますます高まっています。特に、膵臓がん、大腸がん、肝臓がんなど消化器系がんに対する治療法の確立は重要な研究課題となっております。
このような中、本講座では、細胞周期とその細胞内制御機構に着目し、正常細胞には影響を与えず、がん細胞の無秩序な増殖を特異的に制御する機能分子や遺伝子治療法の開発研究 (下記の (1) から (4)) を行なっています。
- (1) がん細胞の細胞周期に対するRNA干渉などによる遺伝子治療法の開発
- (2) 細胞周期を特異的に制御する機能分子 (低中分子化合物) の探索
- (3) 動物レベルでの薬効評価
- (4) 細胞レベル及び動物レベルでのがん進展と細胞周期調節機構の解明
最終的には、既存の抗がん剤や治療法とは異なる、「次世代」のがん治療法の開発をおこない、医療現場への提供することを目指しております。
教員
構成員名 | 役職 | 所属 |
---|---|---|
川嶋 啓揮 | 教授 | 消化器内科 |
石上 雅敏 | 准教授 | 消化器内科(肝臓) |
本多 隆 | 講師 | 消化器内科(肝臓) |
中村 正直 | 講師 | 消化器内科(消化管) |
大野 栄三郎 | 病院講師 | 消化器内科(胆膵) |
古川 和宏 | 病院講師 | 消化器内科(消化管) |
石川 卓哉 | 助教 | 消化器内科(胆膵) |
石津 洋二 | 助教 | 消化器内科(肝臓) |
山村 健史 | 助教 | 消化器内科(消化管) |
前田 啓子 | 助教 | 消化器内科(消化管) |
今井 則博 | 病院助教 | 光学診療部(肝臓) |
伊藤 隆徳 | 病院助教 | 消化器内科(肝臓) |
山雄 健太郎 | 病院助教 | 光学診療部(胆膵) |
澤田 つな騎 | 病院助教 | 光学診療部(消化管) |
田中 卓 | 病院助教 | 救急科(肝臓) |
水谷 泰之 | 病院助教 | 消化器内科(胆膵) |
石川 恵里 | 病院助教 | 消化器内科(消化管) |
山本 健太 | 病院助教 | 光学診療部(肝臓) |
横山 晋也 | 病院助教 | 消化器内科(肝臓) |
飯田 忠 | 病院助教 | 消化器内科(胆膵) |
研究実績
- 2021年
- Hatta W, Tsuji Y, Yoshio T, Kakushima N, Hoteya S, Doyama H, Nagami Y, Hikichi T, Kobayashi M, Morita Y, Sumiyoshi T, Iguchi M, Tomida H, Inoue T, Koike T, Mikami T, Hasatani K, Nishikawa J, Matsumura T, Nebiki H, Nakamatsu D, Ohnita K, Suzuki H, Ueyama H, Hayashi Y, Sugimoto M, Yamaguchi S, Michida T, Yada T, Asahina Y, Narasaka T, Kuribasyashi S, Kiyotoki S, Mabe K, Nakamura T, Nakaya N, Fujishiro M, Masamune A. Prediction model of bleeding after endoscopic submucosal dissection for early gastric cancer: BEST-J score Gut 10.1136/gutjnl-2019-319926
- Nakamura M, Yamamura T, Maeda K, Sawada T, Mizutani Y, Ishikawa E, Kakushima N, Furukawa K, Ishikawa T, Ohno E, Honda T, Kawashima H, Ishigami M, Fujishiro M. Clinical Features of Ischemic Enteritis Diagnosed by Double-Balloon Endoscopy Can J Gastroenterol Hepatol 10.1155/2021/8875564
- Honda T, Ishigami M, Yamamoto K, Takeyama T, Ito T, Ishizu Y, Kuzuya T, Nakamura M, Kawashima H, Miyahara R, Ishikawa T, Hirooka Y, Fujishiro M. Changes in the gut microbiota after hepatitis C virus eradication Sci Rep 10.1038/s41598-021-03009-0
- Ishikawa T, Kawashima H, Ohno E, Mizutani Y, Fujishiro M. Imaging diagnosis of autoimmune pancreatitis using endoscopic ultrasonography J Med Ultrason (2001) 10.1007/s10396-021-01143-w
- Ishizu Y, Ishigami M, Honda T, Imai N, Ito T, Yamamoto K, Fujishiro M. Impact of visceral fat accumulation on the prognosis of patients with cirrhosis Clin Nutr ESPEN 10.1016/j.clnesp.2021.01.008
- Ishikawa E, Satou A, Nakamura M, Nakamura S, Fujishiro M. Epstein-Barr Virus Positive B-Cell Lymphoproliferative Disorder of the Gastrointestinal Tract Cancers (Basel) 10.3390/cancers13153815
- Shiroma S, Hatta W, Tsuji Y, Yoshio T, Yabuuchi Y, Hoteya S, Tsuji S, Nagami Y, Hikichi T, Kobayashi M, Morita Y, Sumiyoshi T, Iguchi M, Tomida H, Inoue T, Mikami T, Hasatani K, Nishikawa J, Matsumura T, Nebiki H, Nakamatsu D, Ohnita K, Suzuki H, Ueyama H, Hayashi Y, Sugimoto M, Yamaguchi S, Michida T, Yada T, Asahina Y, Narasaka T, Kuribayashi S, Kiyotoki S, Mabe K, Fujishiro M, Masamune A, Fujisaki J. Timing of bleeding and thromboembolism associated with endoscopic submucosal dissection for gastric cancer in Japan J Gastroenterol Hepatol 10.1111/jgh.15536
- Sugiyama Y, Ishizu Y, Ando Y, Yokoyama S, Yamamoto K, Ito T, Imai N, Nakamura M, Honda T, Kawashima H, Ishikawa T, Ishigami M. Obesity and myosteatosis: the two characteristics of dynapenia in patients with cirrhosis Eur J Gastroenterol Hepatol 10.1097/MEG.0000000000002303
- Nishikawa T, Maeda K, Nakamura M, Yamamura T, Sawada T, Mizutani Y, Ito T, Ishikawa T, Furukawa K, Ohno E, Miyahara R, Kawashima H, Honda T, Ishigami M, Yamamoto T, Matsumoto S, Hotta Y, Fujishiro M. Filtrated Adipose Tissue-Derived Mesenchymal Stem Cell Lysate Ameliorates Experimental Acute Colitis in Mice Dig Dis Sci 10.1007/s10620-020-06359-3
- Uchida G, Nakamura M, Yamamura T, Furukawa K, Kawashima H, Honda T, Ishigami M, Fujishiro M. Systematic review and meta-analysis of the diagnostic and therapeutic yield of small bowel endoscopy in patients with overt small bowel bleeding Dig Endosc 10.1111/den.13669
- Yoshikawa M, Ishikawa T, Ohno E, Iida T, Furukawa K, Nakamura M, Honda T, Ishigami M, Kinoshita F, Kawashima H, Fujishiro M. Variability measurements provide additional value to shear wave elastography in the diagnosis of pancreatic cancer Sci Rep 10.1038/s41598-021-86979-5
- Yokoyama S, Ishizu Y, Ishigami M, Honda T, Kuzuya T, Ito T, Hinoki A, Sumida W, Shirota C, Tainaka T, Makita S, Yokota K, Uchida H, Fujishiro M. Factors associated with bleeding after endoscopic variceal ligation in children Pediatr Int 10.1111/ped.14614
- Hirose T, Kakushima N, Furukawa K, Furune S, Ishikawa E, Sawada T, Maeda K, Yamamura T, Ishikawa T, Ohno E, Nakamura M, Nishida K, Yokoi T, Kawashima H, Fujishiro M. Endocytoscopy Is Useful for the Diagnosis of Superficial Nonampullary Duodenal Epithelial Tumors Digestion 10.1159/000516512
- Yamada K, Nakamura M, Yamamura T, Maeda K, Sawada T, Mizutani Y, Ishikawa E, Ishikawa T, Kakushima N, Furukawa K, Ohno E, Kawashima H, Honda T, Ishigami M, Fujishiro M. Diagnostic yield of colon capsule endoscopy for Crohn's disease lesions in the whole gastrointestinal tract BMC Gastroenterol 10.1186/s12876-021-01657-0
- Esaki M, Yamamura T, Nakamura M, Maeda K, Sawada T, Mizutani Y, Ishikawa E, Furukawa K, Kawashima H, Hirooka Y, Fujishiro M. New modality for the quantitative evaluation of tissue elasticity using a forward-viewing radial-array echoendoscope for colorectal neoplasms Int J Colorectal Dis 10.1007/s00384-020-03790-w
- Yamamoto T, Imai N, Yamamoto K, Ito T, Ishizu Y, Honda T, Okamoto S, Kanematsu T, Suzuki N, Matsushita T, Ishigami M, Fujishiro M. Safety and efficacy of percutaneous radiofrequency ablation for hepatocellular carcinoma patients with haemophilia Haemophilia 10.1111/hae.14220
- Yamada K, Sawada T, Nakamura M, Yamamura T, Maeda K, Ishikawa E, Iida T, Mizutani Y, Kakushima N, Ishikawa T, Furukawa K, Ohno E, Honda T, Kawashima H, Ishigami M, Furune S, Hase T, Yokota K, Maeda O, Hashimoto N, Akiyama M, Ando Y, Fujishiro M. Clinical characteristics of gastrointestinal immune-related adverse events of immune checkpoint inhibitors and their association with survival World J Gastroenterol 10.3748/wjg.v27.i41.7190
- Ito T, Ishigami M, Yamamoto T, Mizuno K, Yamamoto K, Imai N, Ishizu Y, Honda T, Kawashima H, Yasuda S, Toyoda H, Yokota K, Hase T, Nishio N, Maeda O, Kato M, Hashimoto N, Hibi H, Kodera Y, Sone M, Ando Y, Akiyama M, Shimoyama Y, Fujishiro M. Clinical course of liver injury induced by immune checkpoint inhibitors in patients with advanced malignancies Hepatol Int 10.1007/s12072-021-10238-y
- Furukawa K, Nakamura M, Kawashima H, Fujishiro M. Endoscopic resection of a duodenal neuroendocrine tumor Rev Esp Enferm Dig 10.17235/reed.2021.8232/2021
- Yamamoto K, Honda T, Yokoyama S, Ma L, Kato A, Ito T, Ishizu Y, Kuzuya T, Nakamura M, Kawashima H, Ishigami M, Tsuji NM, Fujishiro M. Microbiome, fibrosis and tumor networks in a non-alcoholic steatohepatitis model of a choline-deficient high-fat diet using diethylnitrosamine Dig Liver Dis 10.1016/j.dld.2021.02.013
- Saito M, Yamamura T, Nakamura M, Maeda K, Sawada T, Ishikawa E, Mizutani Y, Ishikawa T, Kakushima N, Furukawa K, Ohno E, Kawashima H, Ishigami M, Fujishiro M. Real-world local recurrence rate after cold polypectomy in colorectal polyps less than 10 mm using propensity score matching World J Gastroenterol 10.3748/wjg.v27.i47.8182
- Honda T, Yamada N, Murayama A, Shiina M, Aly HH, Kato A, Ito T, Ishizu Y, Kuzuya T, Ishigami M, Murakami Y, Tanaka T, Moriishi K, Nishitsuji H, Shimotohno K, Ishikawa T, Fujishiro M, Muramatsu M, Wakita T, Kato T. Amino Acid Polymorphism in Hepatitis B Virus Associated With Functional Cure Cell Mol Gastroenterol Hepatol 10.1016/j.jcmgh.2021.07.013
- Suzuki T, Furukawa K, Funasaka K, Ishikawa E, Sawada T, Maeda K, Yamamura T, Ishikawa T, Ohno E, Nakamura M, Kawashima H, Miyahara R, Fujishiro M. Long-Term Prognostic Predictors of Esophageal Squamous Cell Carcinoma Potentially Indicated for Endoscopic Submucosal Dissection Digestion 10.1159/000510091
- Uetsuki K, Kawashima H, Ohno E, Ishikawa T, Iida T, Yamamoto K, Furukawa K, Nakamura M, Honda T, Ishigami M, Hirooka Y, Fujishiro M. Measurement of fasting breath hydrogen concentration as a simple diagnostic method for pancreatic exocrine insufficiency BMC Gastroenterol 10.1186/s12876-021-01776-8
- Kataoka K, Ishikawa T, Ohno E, Mizutani Y, Iida T, Ishikawa E, Furukawa K, Nakamura M, Honda T, Ishigami M, Kawashima H, Hirooka Y, Fujishiro M. Differentiation between pancreatic metastases from renal cell carcinoma and pancreatic neuroendocrine neoplasm using endoscopic ultrasound Pancreatology 10.1016/j.pan.2021.07.001
- Nishikawa T, Nakamura M, Yamamura T, Maeda K, Sawada T, Mizutani Y, Ishikawa E, Ishikawa T, Kakushima N, Furukawa K, Ohno E, Honda T, Kawashima H, Ishigami M, Fujishiro M. Lewis score on capsule endoscopy can predict the prognosis in patients with small bowel lesions of Crohn's disease J Gastroenterol Hepatol 10.1111/jgh.15366
- Otsuka H, Nakamura M, Yamamura T, Maeda K, Sawada T, Mizutani Y, Ishikawa E, Ishikawa T, Kakushima N, Furukawa K, Ohno E, Kawashima H, Honda T, Ishigami M, Fujishiro M. Feasibility of patency capsule and colon capsule endoscopy in patients with suspected gastrointestinal stenosis: a prospective study Nagoya J Med Sci 10.18999/nagjms.83.3.419
- Ishikawa T, Kawashima H, Ohno E, Iida T, Suzuki H, Uetsuki K, Yashika J, Yamada K, Yoshikawa M, Gibo N, Aoki T, Kataoka K, Mori H, Yamamura T, Furukawa K, Nakamura M, Hirooka Y, Fujishiro M. Clinical characteristics and long-term prognosis of autoimmune pancreatitis with renal lesions Sci Rep 10.1038/s41598-020-79899-3
- Matsuzaki I, Ebara T, Tsunemi M, Hatta Y, Yamamoto K, Baba A, Hattori M, Nakamura M, Fujishiro M. Effects of endoscopy-related procedure time on musculoskeletal disorders in Japanese endoscopists: a cross-sectional study Endosc Int Open 10.1055/a-1352-3850
- Kataoka K, Ishikawa T, Ohno E, Iida T, Suzuki H, Uetsuki K, Furukawa K, Nakamura M, Honda T, Ishigami M, Kawashima H, Hirooka Y, Fujishiro M. Endoscopic ultrasound elastography for small solid pancreatic lesions with or without main pancreatic duct dilatation Pancreatology 10.1016/j.pan.2020.12.012
- Nishida T, Nikura R, Nagata N, Honda T, Sunagozaka H, Shiratori Y, Tsuji S, Sumiyoshi T, Fujita T, Kiyotoki S, Yada T, Yamamoto K, Shinozaki T, Nakamatsu D, Yamada A, Fujishiro M. Feasibility and safety of colonoscopy performed by nonexperts for acute lower gastrointestinal bleeding: post hoc analysis Endosc Int Open 10.1055/a-1464-0809
- Suzuki H, Ishikawa T, Ohno E, Iida T, Uetsuki K, Yashika J, Yamada K, Yoshikawa M, Furukawa K, Nakamura M, Honda T, Ishigami M, Kawashima H, Fujishiro M. An initial trial of quantitative evaluation of autoimmune pancreatitis using shear wave elastography and shear wave dispersion in transabdominal ultrasound Pancreatology 10.1016/j.pan.2021.02.014
- Nagami Y, Hatta W, Tsuji Y, Yoshio T, Kakushima N, Hoteya S, Tsuji S, Fukunaga S, Hikichi T, Kobayashi M, Morita Y, Sumiyoshi T, Iguchi M, Tomida H, Inoue T, Mikami T, Hasatani K, Nishikawa J, Matsumura T, Nebiki H, Nakamatsu D, Ohnita K, Suzuki H, Ueyama H, Hayashi Y, Yoshida H, Fujishiro M, Masamune A, Fujiwara Y; Fight-Japan study group. Antithrombotics increase bleeding after endoscopic submucosal dissection for gastric cancer: Nationwide propensity score analysis Dig Endosc 10.1111/den.14151
- Kuno T, Yamamura T, Nakamura M, Maeda K, Sawada T, Mizutani Y, Esaki M, Ishikawa T, Furukawa K, Ohno E, Kawashima H, Fujishiro M. A forward-viewing radial-array echoendoscope is useful for diagnosing the depth of colorectal neoplasia invasion Surg Endosc 10.1007/s00464-020-07936-3
- Tsuji Y, Ushiku T, Shinozaki T, Yamashita H, Seto Y, Fukayama M, Fujishiro M, Oda I, Katai H, Taniguchi H, Hasatani K, Kaizaki Y, Oga A, Nishikawa J, Akasaka R, Endo M, Sugai T, Matsumoto T, Koike K. Risk for lymph node metastasis in Epstein-Barr virus-associated gastric carcinoma with submucosal invasion Dig Endosc 10.1111/den.13823
- Yamamoto K, Honda T, Ito T, Ishizu Y, Kuzuya T, Nakamura M, Miyahara R, Kawashima H, Ishigami M, Fujishiro M. The relationship between oral-origin bacteria in the fecal microbiome and albumin-bilirubin grade in patients with hepatitis C J Gastroenterol Hepatol 10.1111/jgh.15206
- Yoshida K, Desbiolles A, Feldman SF, Ahn SH, Alidjinou EK, Atsukawa M, Bocket L, Brunetto MR, Buti M, Carey I, Caviglia GP, Chen EQ, Cornberg M, Enomoto M, Honda M, Zu Siederdissen CH, Ishigami M, Janssen HLA, Maasoumy B, Matsui T, Matsumoto A, Nishiguchi S, Riveiro-Barciela M, Takaki A, Tangkijvanich P, Toyoda H, van Campenhout MJH, Wang B, Wei L, Yang HI, Yano Y, Yatsuhashi H, Yuen MF, Tanaka E, Lemoine M, Tanaka Y, Shimakawa Y. Hepatitis B Core-Related Antigen to Indicate High Viral Load: Systematic Review and Meta-Analysis of 10,397 Individual Participants Clin Gastroenterol Hepatol 10.1016/j.cgh.2020.04.045
- Matsuda N, Imai N, Kuzuya T, Yamamoto K, Ito T, Ishizu Y, Honda T, Ishigami M, Fujishiro M. Progression After Molecular Targeted Agents: Hepatic Arterial Changes and Transarterial Chemoembolization in Hepatocellular Carcinoma In Vivo 10.21873/invivo.12367
- Toriyama K, Yamamura T, Nakamura M, Maeda K, Sawada T, Mizutani Y, Ishikawa E, Furukawa K, Ishikawa T, Ohno E, Kawashima H, Fujishiro M. An evaluation of resectability among endoscopic treatment methods for rectal neuroendocrine tumors <10 mm Arab J Gastroenterol 10.1016/j.ajg.2021.05.007
- Tanaka H, Kawashima H, Ohno E, Ishikawa T, Iida T, Ishikawa E, Furukawa K, Nakamura M, Honda T, Shimoyama Y, Miyahara R, Kawabe N, Kuzuya T, Hashimoto S, Ishigami M, Hirooka Y, Fujishiro M. Immunohistochemical staining for IMP3 in patients with duodenal papilla tumors: assessment of the potential for diagnosing endoscopic resectability and predicting prognosis BMC Gastroenterol 10.1186/s12876-021-01811-8
- Ito T, Ishigami M, Zou B, Tanaka T, Takahashi H, Kurosaki M, Maeda M, Thin KN, Tanaka K, Takahashi Y, Itoh Y, Oniki K, Seko Y, Saruwatari J, Kawanaka M, Atsukawa M, Hyogo H, Ono M, Ogawa E, Barnett SD, Stave CD, Cheung RC, Fujishiro M, Eguchi Y, Toyoda H, Nguyen MH. The epidemiology of NAFLD and lean NAFLD in Japan: a meta-analysis with individual and forecasting analysis, 1995-2040 Hepatol Int 10.1007/s12072-021-10143-4
- Nakamura M, Yano T, Esaki M, Oka S, Mitsui K, Hirai F, Kawasaki K, Fujishiro M, Torisu T, Tanaka S, Iwakiri K, Kishi M, Matsumoto T, Yamamoto H. Novel ultrathin double-balloon endoscopy for the diagnosis of small-bowel diseases: a multicenter nonrandomized study Endoscopy 10.1055/a-1243-0226
- Hasegawa I, Yamamura T, Suzuki H, Maeda K, Sawada T, Mizutani Y, Ishikawa E, Ishikawa T, Kakushima N, Furukawa K, Ohno E, Kawashima H, Nakamura M, Fujishiro M. Detection of Colorectal Neoplasms Using Linked Color Imaging: A Prospective, Randomized, Tandem Colonoscopy Trial Clin Gastroenterol Hepatol 10.1016/j.cgh.2021.04.004
- Yamamoto T, Imai N, Yamamoto K, Ito T, Ishizu Y, Honda T, Okamoto S, Kanematsu T, Suzuki N, Matsushita T, Ishigami M, Fujishiro M. Tolerability of Molecular-targeted Agents for Hepatocellular Carcinoma Treatment in Haemophiliacs Anticancer Res 10.21873/anticanres.15035
- Muroi K, Miyahara R, Funasaka K, Furukawa K, Sawada T, Maeda K, Yamamura T, Ishikawa T, Ohno E, Nakamura M, Kawashima H, Onoue T, Arima H, Hirooka Y, Fujishiro M. Comparison of High-Resolution Manometry in Patients Complaining of Dysphagia among Patients with or without Diabetes Mellitus Digestion 10.1159/000510081
- Yamada K, Ishikawa T, Ohno E, Iida T, Suzuki H, Uetsuki K, Yashika J, Yoshikawa M, Takami H, Inokawa Y, Uchida H, Kawashima H, Fujishiro M. Double common bile duct associated with pancreaticobiliary maljunction Nagoya J Med Sci 10.18999/nagjms.83.3.655
- Hashimoto M, Hatta W, Tsuji Y, Yoshio T, Yabuuchi Y, Hoteya S, Doyama H, Nagami Y, Hikichi T, Kobayashi M, Morita Y, Sumiyoshi T, Iguchi M, Tomida H, Inoue T, Mikami T, Hasatani K, Nishikawa J, Matsumura T, Nebiki H, Nakamatsu D, Ohnita K, Suzuki H, Ueyama H, Hayashi Y, Sugimoto M, Fujishiro M, Masamune A, Ohira H; Collaborators. Rebleeding in patients with delayed bleeding after endoscopic submucosal dissection for early gastric cancer Dig Endosc 10.1111/den.13943
- Yashika J, Ohno E, Ishikawa T, Iida T, Suzuki H, Uetsuki K, Yamada K, Yoshikawa M, Gibo N, Shimoyama Y, Ishikawa E, Furukawa K, Nakamura M, Honda T, Ishigami M, Hirooka Y, Kawashima H, Fujishiro M. Utility of multiphase contrast enhancement patterns on CEH-EUS for the differential diagnosis of IPMN-derived and conventional pancreatic cancer Pancreatology 10.1016/j.pan.2020.12.022
- Ohno E, Kawashima H, Ishikawa T, Iida T, Suzuki H, Uetsuki K, Yashika J, Yamada K, Yoshikawa M, Gibo N, Aoki T, Kataoka K, Mori H, Yamamura T, Furukawa K, Nakamura M, Hirooka Y, Fujishiro M. Diagnostic performance of endoscopic ultrasonography-guided elastography for solid pancreatic lesions: Shear-wave measurements versus strain elastography with histogram analysis Dig Endosc 10.1111/den.13791
- Esaki M, Yamamura T, Nakamura M, Maeda K, Sawada T, Mizutani Y, Ishikawa E, Suzuki H, Kuno T, Yamada K, Hasegawa I, Ishikawa T, Kakushima N, Furukawa K, Ohno E, Kawashima H, Hirooka Y, Fujishiro M. Endoscopic Ultrasound Elastography as a Novel Diagnostic Method for the Assessment of Hardness and Depth of Invasion in Colorectal Neoplasms Digestion 10.1159/000511589
- Ito N, Funasaka K, Furukawa K, Kakushima N, Hirose T, Muroi K, Suzuki T, Suzuki T, Hida E, Ishikawa T, Yamamura T, Ohno E, Nakamura M, Kawashima H, Miyahara R, Fujishiro M. A novel scoring system to predict therapeutic intervention for non-variceal upper gastrointestinal bleeding Intern Emerg Med 10.1007/s11739-021-02822-9
- Tsutsumi K, Kato M, Kakushima N, Iguchi M, Yamamoto Y, Kanetaka K, Uraoka T, Fujishiro M, Sho M; Japan Duodenal Cancer Guideline Committee. Efficacy of endoscopic preventive procedures to reduce delayed adverse events after endoscopic resection of superficial nonampullary duodenal epithelial tumors: a meta-analysis of observational comparative trials Gastrointest Endosc 10.1016/j.gie.2020.08.017
- Kawashima H, Ohno E, Ishikawa T, Iida T, Tanaka H, Furukawa K, Nakamura M, Honda T, Hashimoto S, Itoh A, Ishigami M, Hirooka Y, Fujishiro M. Endoscopic papillectomy for ampullary adenoma and early adenocarcinoma: Analysis of factors related to treatment outcome and long-term prognosis Dig Endosc 10.1111/den.13881
- Yoshioka N, Tanaka M, Ochi K, Watanabe A, Ono K, Sawada M, Ogi T, Itoh M, Ito A, Shiraki Y, Enomoto A, Ishigami M, Fujishiro M, Ogawa Y, Suganami T. The sodium-glucose cotransporter-2 inhibitor Tofogliflozin prevents the progression of nonalcoholic steatohepatitis-associated liver tumors in a novel murine model Biomed Pharmacother 10.1016/j.biopha.2021.111738
- Muto H, Ito T, Tanaka T, Yokoyama S, Yamamoto K, Imai N, Ishizu Y, Maeda K, Honda T, Ishikawa T, Kato A, Ohshiro T, Kano F, Yamamoto A, Sakai K, Hibi H, Ishigami M, Fujishiro M. Conditioned medium from stem cells derived from human exfoliated deciduous teeth ameliorates NASH via the Gut-Liver axis Sci Rep 10.1038/s41598-021-98254-8
- Aoki T, Yamada A, Kato Y, Saito H, Tsuboi A, Nakada A, Niikura R, Fujishiro M, Oka S, Ishihara S, Matsuda T, Nakahori M, Tanaka S, Koike K, Tada T. Automatic detection of various abnormalities in capsule endoscopy videos by a deep learning-based system: a multicenter study Gastrointest Endosc 10.1016/j.gie.2020.04.080
- Suzuki H, Ishikawa T, Ohno E, Kawashima H, Fujishiro M. Gastrointestinal: Pancreatic metastasis from extramammary Paget's disease diagnosed by endoscopic ultrasound-guided fine-needle biopsy J Gastroenterol Hepatol 10.1111/jgh.15444
- Kiyotoki S, Nishikawa J, Nagata N, Niikura R, Doyama H, Imagawa A, Hasatani K, Hatta W, Sumiyoshi T, Nebiki H, Nagami Y, Nishida T, Kakushima N, Iguchi M, Tomida H, Inoue T, Kuribayashi S, Narasaka T, Hikichi T, Yada T, Ochiai Y, Furuhashi H, Yoshio T, Mori H, Yamauchi K, Kitamura K, Fujita T, Mabe K, Mikami T, Goto A, Akashi M, Hamamoto Y, Fujishiro M, Sakaida I. Exploration of the characteristics of chronotypes in upper gastrointestinal tract diseases: a multicenter study in Japan Chronobiol Int 10.1080/07420528.2020.1830791
- Kobayashi K, Furukawa K, Ishikawa E, Mitsuma A, Funasaka K, Kakushima N, Furune S, Ito N, Wada H, Hirose T, Muroi K, Suzuki T, Suzuki T, Hida E, Hirai K, Shibata H, Koya T, Nakamura M, Kawashima H, Miyahara R, Fujishiro M. Collision Tumors of Gastric Adenocarcinoma and Mucosa-associated Lymphoid Tissue Lymphoma Intern Med 10.2169/internalmedicine.6124-20
- Ishizu Y, Ishigami M, Honda T, Kuzuya T, Ito T, Komada T, Fujishiro M. Simplification of balloon-occluded retrograde transcatheter obliteration procedure using a coaxial double balloon catheter compared with a single-balloon catheter Jpn J Radiol 10.1007/s11604-020-01060-x
- Muroi K, Kakushima N, Furukawa K, Ishikawa E, Sawada T, Ishikawa T, Maeda K, Yamamura T, Ohno E, Nakamura M, Kawashima H, Funasaka K, Miyahara R, Fujishiro M. Subjective Symptoms in Patients with Eosinophilic Esophagitis Are Related to Esophageal Wall Thickness and Esophageal Body Pressure Dig Dis Sci 10.1007/s10620-020-06527-5
- Yoshida M, Yabuuchi Y, Kakushima N, Kato M, Iguchi M, Yamamoto Y, Kanetaka K, Uraoka T, Fujishiro M, Sho M; Japan Duodenal Cancer Guideline Committee. The incidence of non-ampullary duodenal cancer in Japan: The first analysis of a national cancer registry J Gastroenterol Hepatol 10.1111/jgh.15285
- Ishikawa E, Nakaguro M, Nakamura M, Yamamura T, Sawada T, Mizutani Y, Maeda K, Furukawa K, Shimoyama Y, Kawashima H, Fujishiro M. Gastrointestinal tract metastasis of lung cancer: The PD-L1 expression and correlated clinicopathological variables Pathol Int 10.1111/pin.13048
- Furukawa K, Sato K, Okachi S, Kawashima H, Fujishiro M. Surgical mask designed for endoscopic procedures to prevent the diffusion of droplets Acta Gastroenterol Belg 10.51821/84.3.024
- Imai N, Yokoyama S, Yamamoto K, Ito T, Ishizu Y, Honda T, Ishigami M. Safety and Efficacy of Glass Membrane Pumping Emulsification Device in Transarterial Chemoembolization for Hepatocellular Carcinoma: First Clinical Outcomes Anticancer Res 10.21873/anticanres.15399
- Ozawa N, Sato K, Sugimura A, Maki S, Tanaka T, Yamamoto K, Ito T, Ishizu Y, Kuzuya T, Honda T, Ishigami M, Fujishiro M, Ishikawa T, Ando S. Quality of Life in patients with nonalcoholic fatty liver disease: Structure and related factors focusing on illness uncertainty Jpn J Nurs Sci 10.1111/jjns.12415
- Ishigami M, Honda T, Ishizu Y, Imai N, Ito T, Yamamoto K, Kamei H, Ogura Y, Fujishiro M. Revisiting Prognosis After Liver Transplant in Patients Positive for Hepatitis C Virus: Focus on Hepatitis C Recurrence-Unrelated Complications Exp Clin Transplant 10.6002/ect.2021.0197
- Muto H, Kuzuya T, Ito T, Ishizu Y, Honda T, Ishikawa T, Ishigami M, Fujishiro M. Transient deterioration of albumin-bilirubin scores in early post-dose period of molecular targeted therapies in advanced hepatocellular carcinoma with 50% or higher liver occupation: A STROBE-compliant retrospective observational study Medicine (Baltimore) 10.1097/MD.0000000000026820
- Zhao R, Nakamura M, Wu S, Uchida G, Yamamura T, Gao YJ, Goto H, Fujishiro M, Ge ZZ. The role of early video capsule endoscopy in the diagnosis and prognosis of obscure gastrointestinal bleeding: A multi-center propensity score matching study J Gastroenterol Hepatol 10.1111/jgh.15491
- Tomida H, Yoshio T, Igarashi K, Morita Y, Oda I, Inoue T, Hikichi T, Sumiyoshi T, Doyama H, Tsuji Y, Nishikawa J, Hatta W, Mikami T, Iguchi M, Sumiyama K, Yamamoto K, Kitamura K, Kuribayashi S, Yanagitani A, Uraoka T, Yada T, Hasatani K, Kawaguchi K, Fujita T, Nishida T, Hiasa Y, Fujishiro M; FIGHT-Japan Study Group. Influence of anticoagulants on the risk of delayed bleeding after gastric endoscopic submucosal dissection: a multicenter retrospective study Gastric Cancer 10.1007/s10120-020-01105-0
- Niikura R, Fujishiro M, Nakai Y, Matsuda K, Kawahara T, Yamada A, Tsuji Y, Hayakawa Y, Koike K. International Observational Survey of the Effectiveness of Personal Protective Equipment during Endoscopic Procedures Performed in Patients with COVID-19 Digestion 10.1159/000513714
- Amano H, Shirota C, Tainaka T, Sumida W, Yokota K, Makita S, Takimoto A, Tanaka Y, Hinoki A, Kawashima H, Uchida H. Late postoperative complications of congenital biliary dilatation in pediatric patients: a single-center experience of managing complications for over 20 years Surg Today 10.1007/s00595-021-02238-0
- Takada Y, Ishikawa T, Kawashima H. An Unusual Pancreatic Mass with Ductal Disruption: Benign or Malignant? Gastroenterology 10.1053/j.gastro.2021.06.059
- Murate K, Nakamura M, Yamamura T, Maeda K, Sawada T, Mizutani Y, Ishikawa E, Kakushima N, Furukawa K, Ohno E, Honda T, Kawashima H, Ishigami M, Fujishiro M. Ustekinumab is effective against small bowel lesions in Crohn's disease: two case reports Clin J Gastroenterol 10.1007/s12328-020-01242-0
- Yabuuchi Y, Hatta W, Tsuji Y, Yoshio T, Kakushima N, Hoteya S, Doyama H, Nagami Y, Hikichi T, Kobayashi M, Morita Y, Sumiyoshi T, Iguchi M, Tomida H, Inoue T, Mikami T, Hasatani K, Nishikawa J, Matsumura T, Nebiki H, Nakamatsu D, Ohnita K, Suzuki H, Ueyama H, Hayashi Y, Sugimoto M, Yamaguchi S, Michida T, Yada T, Asahina Y, Narasaka T, Kuribayashi S, Kiyotoki S, Mabe K, Fujishiro M, Masamune A, Ono H. Influence of hospital volume on bleeding after endoscopic submucosal dissection for early gastric cancer in Japan: a multicenter propensity score-matched analysis Surg Endosc 10.1007/s00464-021-08721-6
- Ishikawa T, Ohno E, Mizutani Y, Iida T, Koya T, Sasaki Y, Ogawa H, Kinoshita F, Hirooka Y, Kawashima H. Comparison of contrast-enhanced transabdominal ultrasonography following endoscopic ultrasonography with GD-EOB-DTPA-enhanced MRI for the sequential diagnosis of liver metastasis in patients with pancreatic cancer J Hepatobiliary Pancreat Sci 10.1002/jhbp.1097
- Shimada M, Hirashima N, Iwase H, Saito M, Kondo H, Urata N, Unita S, Kondo T, Tanaka D, Tsunekawa T, Fujishiro M. Evaluation of Muscle Cramp Associated with Liver Cirrhosis with a Focus on the Liver Function and Nutritional Status Intern Med 10.2169/internalmedicine.6231-20
- Shirota C, Kawashima H, Tainaka T, Sumida W, Yokota K, Makita S, Amano H, Takimoto A, Hinoki A, Uchida H. Double-balloon endoscopic retrograde cholangiography can make a reliable diagnosis and good prognosis for postoperative complications of congenital biliary dilatation Sci Rep 10.1038/s41598-021-90550-7
- Ishikawa T, Kawashima H, Ohno E, Nakamura M, Yamada S, Hayashi M, Fujishiro M. Endoscopic removal of a fish bone piercing the bile duct after pancreaticoduodenectomy Endoscopy 10.1055/a-1224-3724
- Sugimoto M, Hatta W, Tsuji Y, Yoshio T, Yabuuchi Y, Hoteya S, Doyama H, Nagami Y, Hikichi T, Kobayashi M, Morita Y, Sumiyoshi T, Iguchi M, Tomida H, Inoue T, Mikami T, Hasatani K, Nishikawa J, Matsumura T, Nebiki H, Nakamatsu D, Ohnita K, Suzuki H, Ueyama H, Hayashi Y, Murata M, Yamaguchi S, Michida T, Yada T, Asahina Y, Narasaka T, Kuribayashi S, Kiyotoki S, Mabe K, Fujishiro M, Masamune A, Kawai T. Risk Factors for Bleeding After Endoscopic Submucosal Dissection for Gastric Cancer in Elderly Patients Older Than 80 Years in Japan Clin Transl Gastroenterol 10.14309/ctg.0000000000000404
- Nishida T, Niikura R, Nagata N, Honda T, Sunagozaka H, Shiratori Y, Tsuji S, Sumiyoshi T, Fujita T, Kiyotoki S, Yada T, Yamamoto K, Shinozaki T, Nakamatsu D, Yamada A, Fujishiro M. Erratum: Feasibility and safety of colonoscopy performed by nonexperts for acute lower gastrointestinal bleeding: post hoc analysis Endosc Int Open 10.1055/a-1548-4517
- Yamamoto T, Hamajima E, Kamioka T, Nakae Y, Nakashima S, Kuno T, Ito M, Fujishiro M. [A case of mucosal prolapse syndrome complicated by well-differentiated tubular adenocarcinoma and high-grade adenoma after long-term follow-up by colonoscopy] Nihon Shokakibyo Gakkai Zasshi 10.11405/nisshoshi.118.757
- Shimada M, Hirashima N, Iwase H, Saito M, Kondo H, Urata N, Unita S, Kondo T, Tanaka D, Tsunekawa T, Nakamura S, Nishikura M, Miyazawa K, Fukuhara K, Fujishiro M. Evaluating patient acceptability and bowel preparation efficacy of sodium picosulfate-magnesium citrate for colonoscopy DEN open 10.1002/deo2.59
- Sakamoto Y, Yoshio S, Doi H, Mori T, Matsuda M, Kawai H, Shimagaki T, Yoshikawa S, Aoki Y, Osawa Y, Yoshida Y, Arai T, Itokawa N, Atsukawa M, Ito T, Honda T, Mise Y, Ono Y, Takahashi Y, Saiura A, Taketomi A, Kanto T. Increased Frequency of Dysfunctional Siglec-7(-)CD57(+)PD-1(+) Natural Killer Cells in Patients With Non-alcoholic Fatty Liver Disease Front Immunol 10.3389/fimmu.2021.603133
- Nakamura M, Watanabe K, Ohmiya N, Hirai F, Omori T, Tokuhara D, Nakaji K, Nouda S, Esaki M, Sameshima Y, Goto H, Terano A, Tajiri H, Matsui T; J-POP study group. Tag-less patency capsule for suspected small bowel stenosis: Nationwide multicenter prospective study in Japan Dig Endosc 10.1111/den.13673
- Kita T, Ashizuka S, Ohmiya N, Yamamoto T, Kanai T, Motoya S, Hirai F, Nakase H, Moriyama T, Nakamura M, Suzuki Y, Kanmura S, Kobayashi T, Ohi H, Nozaki R, Mitsuyama K, Yamamoto S, Inatsu H, Watanabe K, Hibi T, Kitamura K. Adrenomedullin for steroid-resistant ulcerative colitis: a randomized, double-blind, placebo-controlled phase-2a clinical trial J Gastroenterol 10.1007/s00535-020-01741-4
- Watanabe K, Ohmiya N, Nakamura M, Fujiwara Y. A Prospective Study Evaluating the Clinical Utility of the Tag-Less Patency Capsule with Extended Time for Confirming Functional Patency Digestion 10.1159/000503027
- Yamashita K, Yube Y, Yamazaki Y, Fukuchi T, Kato M, Koike T, Uehara T, Ikeda Y, Furune S, Murakami H, Kubota E, Fujioka S, Sato Y, Jin X, Suzuki T, Furukawa K, Tsuboi Y. The impact of tube replacement timing during LCIG therapy on PEG-J associated adverse events: a retrospective multicenter observational study BMC Neurol 10.1186/s12883-021-02269-7
- Ohno E. Paradigm shift in image-enhanced endoscopic ultrasonography Dig Endosc 10.1111/den.13906
- Ohno E, Hirooka Y. Encyclopedia of autoimmune pancreatitis: this is all we need J Med Ultrason (2001) 10.1007/s10396-021-01150-x
- Kitano M, Yamashita Y, Kamata K, Ang TL, Imazu H, Ohno E, Hirooka Y, Fusaroli P, Seo DW, Napoléon B, Teoh AYB, Kim TH, Dietrich CF, Wang HP, Kudo M; Working group for the International Consensus Guidelines for Contrast-Enhanced Harmonic Endoscopic Ultrasound. The Asian Federation of Societies for Ultrasound in Medicine and Biology (AFSUMB) Guidelines for Contrast-Enhanced Endoscopic Ultrasound Ultrasound Med Biol 10.1016/j.ultrasmedbio.2021.01.030
- Li Y, Imai N, Nicholls HT, Roberts BR, Goyal S, Krisko TI, Ang LH, Tillman MC, Roberts AM, Baqai M, Ortlund EA, Cohen DE, Hagen SJ. Thioesterase superfamily member 1 undergoes stimulus-coupled conformational reorganization to regulate metabolism in mice Nat Commun. 10.1038/s41467-021-23595-x
- Ritter MJ, Amano I, Imai N, Soares De Oliveira L, Vella KR, Hollenberg AN Nuclear Receptor CoRepressors, NCOR1 and SMRT, are required for maintaining systemic metabolic homeostasis Mol Metab doi: 10.1016/j.molmet.2021.101315
- 2020年
- Niikura R, Nagata N, Yamada A, Honda T, Hasatani K, Ishii N, Shiratori Y, Doyama H, Nishida T, Sumiyoshi T, Fujita T, Kiyotoki S, Yada T, Yamamoto K, Shinozaki T, Takata M, Mikami T, Mabe K, Hara K, Fujishiro M, Koike K. Efficacy and Safety of Early vs Elective Colonoscopy for Acute Lower Gastrointestinal Bleeding Gastroenterology 10.1053/j.gastro.2019.09.010
- Yoshioka N, Ishigami M, Watanabe Y, Sumi H, Doisaki M, Yamaguchi T, Ito T, Ishizu Y, Kuzuya T, Honda T, Ishikawa T, Haruta JI, Fujishiro M. Effect of weight change and lifestyle modifications on the development or remission of nonalcoholic fatty liver disease: sex-specific analysis Sci Rep 10.1038/s41598-019-57369-9
- Taylor RS, Taylor RJ, Bayliss S, Hagström H, Nasr P, Schattenberg JM, Ishigami M, Toyoda H, Wai-Sun Wong V, Peleg N, Shlomai A, Sebastiani G, Seko Y, Bhala N, Younossi ZM, Anstee QM, McPherson S, Newsome PN. Association Between Fibrosis Stage and Outcomes of Patients With Nonalcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis Gastroenterology 10.1053/j.gastro.2020.01.043
- Ohno E, Hirooka Y, Kawashima H, Ishikawa T, Fujishiro M. Endoscopic ultrasonography for the evaluation of pancreatic cystic neoplasms J Med Ultrason (2001) 10.1007/s10396-019-00980-0
- Yamada K, Kawashima H, Ohno E, Ishikawa T, Tanaka H, Nakamura M, Miyahara R, Ishigami M, Hirooka Y, Fujishiro M. Diagnosis of vascular invasion in pancreatic ductal adenocarcinoma using endoscopic ultrasound elastography BMC Gastroenterol 10.1186/s12876-020-01228-9
- Furukawa K, Miyahara R, Funasaka K, Fujishiro M. Localized Gastric Amyloidosis J Gastrointestin Liver Dis 10.15403/jgld-3088
- Sasaki Y, Ishikawa T, Kawashima H, Ohno E, Shimoyama Y, Ishikawa E, Fujishiro M. Gender difference in the transabdominal ultrasound findings of solid-pseudopapillary neoplasm Pancreatology 10.1016/j.pan.2020.06.016
- Hosono I, Miyahara R, Furukawa K, Funasaka K, Sawada T, Maeda K, Yamamura T, Ishikawa T, Ohno E, Nakamura M, Kawashima H, Yokoi T, Tsukamoto T, Hirooka Y, Fujishiro M. Use of Immunostaining for the diagnosis of Lymphovascular invasion in superficial Barrett's esophageal adenocarcinoma BMC Gastroenterol 10.1186/s12876-020-01319-7
- Suzuki H, Kawashima H, Ohno E, Ishikawa T, Hashimoto S, Nakamura M, Miyahara R, Ishigami M, Hirooka Y, Fujishiro M. What is the role of measuring shear wave dispersion using shear wave elastography in pancreatic parenchyma? J Med Ultrason (2001) 10.1007/s10396-020-01033-7
- Nishio R, Kawashima H, Nakamura M, Ohno E, Ishikawa T, Yamamura T, Maeda K, Sawada T, Tanaka H, Sakai D, Miyahara R, Ishigami M, Hirooka Y, Fujishiro M. Double-balloon endoscopic retrograde cholangiopancreatography for patients who underwent liver operation: A retrospective study World J Gastroenterol 10.3748/wjg.v26.i10.1056
- Fujishiro M, Furukawa K, Yamamura T, Nakamura M, Honda T, Maeda O, Ishigami M, Kawashima H. Nonexposed wall-inversion surgery as a novel local resection method for neoplasms in the gastrointestinal tract Nagoya J Med Sci 10.18999/nagjms.82.2.175
- Zorron Cheng Tao Pu L, Chiam KH, Yamamura T, Nakamura M, Berzin TM, Mir FF, Hourneaux de Moura EG, Madruga Neto AC, Koay DSC, Loong CK, Ovenden A, Edwards S, Burt AD, Hirooka Y, Fujishiro M, Singh R. Narrow-band imaging for scar (NBI-SCAR) classification: from conception to multicenter validation Gastrointest Endosc 10.1016/j.gie.2019.08.036
- Furukawa K, Nakamura M, Fujishiro M. [Endoscopic screening for gastric cancer] Nihon Shokakibyo Gakkai Zasshi 10.11405/nisshoshi.117.469
- Murate K, Maeda K, Nakamura M, Sugiyama D, Wada H, Yamamura T, Sawada T, Mizutani Y, Ishikawa T, Furukawa K, Ohno E, Honda T, Kawashima H, Miyahara R, Ishigami M, Nishikawa H, Fujishiro M. Endoscopic Activity and Serum TNF-α Level at Baseline Are Associated With Clinical Response to Ustekinumab in Crohn's Disease Patients Inflamm Bowel Dis 10.1093/ibd/izaa086
- Niwa Y, Nakamura M, Kawashima H, Yamamura T, Maeda K, Sawada T, Mizutani Y, Ishikawa E, Ishikawa T, Kakushima N, Furukawa K, Ohno E, Honda T, Ishigami M, Fujishiro M. Accuracy of carbon dioxide insufflation for endoscopic retrograde cholangiopancreatography using double-balloon endoscopy World J Gastroenterol 10.3748/wjg.v26.i42.6669
- Kataoka Y, Tsuji Y, Hirasawa K, Takimoto K, Wada T, Mochizuki S, Ohata K, Sakaguchi Y, Niimi K, Ono S, Kodashima S, Yamamichi N, Fujishiro M, Koike K. Reply to Murakami et al Endoscopy 10.1055/a-1026-6136
- Yamamoto K, Kuzuya T, Honda T, Ito T, Ishizu Y, Nakamura M, Miyahara R, Kawashima H, Ishigami M, Fujishiro M. Relationship Between Adverse Events and Microbiomes in Advanced Hepatocellular Carcinoma Patients Treated With Sorafenib Anticancer Res 10.21873/anticanres.13996
- Saito H, Tanimoto T, Ozawa T, Ishihara S, Fujishiro M, Shichijo S, Hirasawa D, Matsuda T, Endo Y, Tada T. Automatic anatomical classification of colonoscopic images using deep convolutional neural networks Gastroenterol Rep (Oxf) 10.1093/gastro/goaa078
- Hattori S, Nakamura M, Yamamura T, Maeda K, Sawada T, Mizutani Y, Yamamoto K, Ishikawa T, Furukawa K, Ohno E, Honda T, Kawashima H, Ishigami M, Hirooka Y, Fujishiro M. The microbiome can predict mucosal healing in small intestine in patients with Crohn's disease J Gastroenterol 10.1007/s00535-020-01728-1
- Ishikawa T, Kawashima H, Ohno E, Iida T, Suzuki H, Uetsuki K, Yamada K, Yashika J, Yoshikawa M, Gibo N, Aoki T, Kataoka K, Mori H, Fujishiro M. Risks and characteristics of pancreatic cancer and pancreatic relapse in autoimmune pancreatitis patients J Gastroenterol Hepatol 10.1111/jgh.15163
- Ozawa T, Ishihara S, Fujishiro M, Kumagai Y, Shichijo S, Tada T. Automated endoscopic detection and classification of colorectal polyps using convolutional neural networks Therap Adv Gastroenterol 10.1177/1756284820910659
- Tanaka T, Kuzuya T, Ishigami M, Ito T, Ishizu Y, Honda T, Ishikawa T, Fujishiro M. Efficacy and Safety of Sorafenib in Unresectable Hepatocellular Carcinoma with Bile Duct Invasion Oncology 10.1159/000507051
- Zorron Cheng Tao Pu L, Maicas G, Tian Y, Yamamura T, Nakamura M, Suzuki H, Singh G, Rana K, Hirooka Y, Burt AD, Fujishiro M, Carneiro G, Singh R. Computer-aided diagnosis for characterization of colorectal lesions: comprehensive software that includes differentiation of serrated lesions Gastrointest Endosc 10.1016/j.gie.2020.02.042
- Zorron Cheng Tao Pu L, Yamamura T, Nakamura M, Koay DSC, Ovenden A, Edwards S, Burt AD, Hirooka Y, Fujishiro M, Singh R. Comparison of different virtual chromoendoscopy classification systems for the characterization of colorectal lesions JGH Open 10.1002/jgh3.12382
- Suzuki H, Nakamura M, Yamamura T, Maeda K, Sawada T, Mizutani Y, Ishikawa T, Furukawa K, Ohno E, Honda T, Kawashima H, Ishigami M, Fujishiro M. A Prospective Study of Factors Associated with Abdominal Pain in Patients during Unsedated Colonoscopy Using a Magnifying Endoscope Intern Med 10.2169/internalmedicine.4267-19
- Zorron Cheng Tao Pu L, Rana K, Singh G, Nakamura M, Yamamura T, Koay DSC, Ovenden A, Edwards S, Ruszkiewicz A, Hirooka Y, Fujishiro M, Burt AD, Singh R. Different factors are associated with conventional adenoma and serrated colorectal neoplasia Nagoya J Med Sci 10.18999/nagjms.82.2.335
- Sakamaki K, Funasaka K, Miyahara R, Furukawa K, Yamamura T, Ohno E, Nakamura M, Kawashima H, Hirooka Y, Fujishiro M, Goto H. Low ETV1 mRNA expression is associated with recurrence in gastrointestinal stromal tumors Sci Rep 10.1038/s41598-020-71719-y
- Ishimaru T, Kawashima H, Tainaka T, Suzuki K, Takami S, Kakihara T, Katoh R, Aoyama T, Uchida H, Iwanaka T. Laparoscopically Assisted Anorectoplasty for Intermediate-Type Imperforate Anus: Comparison of Surgical Outcomes with the Sacroperineal Approach J Laparoendosc Adv Surg Tech A 10.1089/lap.2018.0330
- Ohno E, Kawashima H, Ishikawa T, Iida T, Suzuki H, Uetsuki K, Yashika J, Yamada K, Yoshikawa M, Gibo N, Aoki T, Kataoka K, Mori H, Hirooka Y, Fujishiro M. Can contrast-enhanced harmonic endoscopic ultrasonography accurately diagnose main pancreatic duct involvement in intraductal papillary mucinous neoplasms? Pancreatology 10.1016/j.pan.2020.06.004
- Matsui K, Funasaka K, Miyahara R, Furukawa K, Matsushita M, Yamamura T, Ishikawa T, Ohno E, Nakamura M, Kawashima H, Watanabe O, Ohara K, Hirooka Y, Goto H. Generation of magnifying endoscopic images of gastric neoplasms based on an all-in-focus algorithm J Gastroenterol Hepatol 10.1111/jgh.14792
- Yamada K, Nakamura M, Yamamura T, Maeda K, Sawada T, Mizutani Y, Ishikawa T, Furukawa K, Ohno E, Miyahara R, Kawashima H, Hotta N, Hirooka Y. Clinical Factors Associated with Missing Colorectal Polyp on Colon Capsule Endoscopy Digestion 10.1159/000498942
- Ito T, Ishigami M, Morooka H, Yamamoto K, Imai N, Ishizu Y, Honda T, Nishimura D, Tada T, Yasuda S, Toyoda H, Kumada T, Fujishiro M. The albumin-bilirubin score as a predictor of outcomes in Japanese patients with PBC: an analysis using time-dependent ROC Sci Rep 10.1038/s41598-020-74732-3
- Emura F, Sharma P, Arantes V, Cerisoli C, Parra-Blanco A, Sumiyama K, Araya R, Sobrino S, Chiu P, Matsuda K, Gonzalez R, Fujishiro M, Tajiri H. Principles and practice to facilitate complete photodocumentation of the upper gastrointestinal tract: World Endoscopy Organization position statement Dig Endosc 10.1111/den.13530
- Zorron Cheng Tao Pu L, Yamamura T, Nakamura M, Esaki M, Kaosombatwattana U, Rodriguez MR, Edwards S, Burt AD, Singh R, Hirooka Y, Fujishiro M. Learning curve for mastery of colorectal endoscopic submucosal dissection: Perspectives from a large Japanese cohort JGH Open 10.1002/jgh3.12298
- Nomura A, Ishigami M, Honda T, Kuzuya T, Ishizu Y, Ito T, Kamei H, Onishi Y, Ogura Y, Fujishiro M. Limitation of non-transplant treatment and proper timing for liver transplantation in patients with hepatocellular carcinoma considering long-term survival Medicine (Baltimore) 10.1097/MD.0000000000021161
- Ishikawa E, Nakamura M, Shimada K, Tanaka T, Satou A, Kohno K, Sakakibara A, Furukawa K, Yamamura T, Miyahara R, Nakamura S, Kato S, Fujishiro M. Prognostic impact of PD-L1 expression in primary gastric and intestinal diffuse large B-cell lymphoma J Gastroenterol 10.1007/s00535-019-01616-3
- Ishikawa T, Kawashima H, Ohno E, Suhara H, Hayashi D, Hiramatsu T, Matsubara H, Suzuki T, Kuwahara T, Ishikawa E, Shimoyama Y, Kinoshita F, Hirooka Y, Fujishiro M. Usefulness of endoscopic ultrasound-guided fine-needle biopsy for the diagnosis of autoimmune pancreatitis using a 22-gauge Franseen needle: a prospective multicenter study Endoscopy 10.1055/a-1183-3583
- Hosokawa T, Hosokawa M, Tanami Y, Sato Y, Ishimaru T, Tanaka Y, Kawashima H, Oguma E. Use of ultrasound findings to predict bowel ischemic changes in pediatric patients with intestinal volvulus J Ultrasound Med 10.1002/jum.15145
- Ogiso S, Kamei H, Onishi Y, Kurata N, Jobara K, Kawashima H, Ogura Y. Decreased long-term graft survival in persistent biliary complications after right-lobe living-donor liver transplantation Clin Transplant 10.1111/ctr.13771
- Ishizu Y, Ishigami M, Hayashi K, Honda T, Kuzuya T, Ito T, Fujishiro M. Rapid increase of platelet counts during antiviral therapy in patients with hepatitis C virus infection Hepatol Res 10.1111/hepr.13426
- Zorron Cheng Tao Pu L, Yamamoto K, Honda T, Nakamura M, Yamamura T, Hattori S, Burt AD, Singh R, Hirooka Y, Fujishiro M. Microbiota profile is different for early and invasive colorectal cancer and is consistent throughout the colon J Gastroenterol Hepatol 10.1111/jgh.14868
- Kuzuya T, Ishigami M, Ito T, Ishizu Y, Honda T, Ishikawa T, Fujishiro M. Initial Experience of Ramucirumab Treatment After Lenvatinib Failure for Patients With Advanced Hepatocellular Carcinoma Anticancer Res 10.21873/anticanres.14167
- Zorron Cheng Tao Pu L, Singh G, Rana K, Nakamura M, Yamamura T, Krishnamurthi S, Ovenden A, Edwards S, Ruszkiewicz A, Hirooka Y, Fujishiro M, Burt AD, Singh R. Polyp Detection Rate as a Surrogate for Adenoma and Sessile Serrated Adenoma/Polyp Detection Rates Gastrointest Tumors 10.1159/000505622
- Mizuno K, Ito T, Ishigami M, Ishizu Y, Kuzuya T, Honda T, Kawashima H, Inukai Y, Toyoda H, Yokota K, Hase T, Maeda O, Kiyoi H, Nagino M, Hibi H, Kodera Y, Fujimoto Y, Sone M, Gotoh M, Ando Y, Akiyama M, Hasegawa Y, Fujishiro M. Real world data of liver injury induced by immune checkpoint inhibitors in Japanese patients with advanced malignancies J Gastroenterol 10.1007/s00535-020-01677-9
- Ishigami M, Honda T, Kuzuya T, Ishizu Y, Ito T, Kamei H, Ogura Y, Fujishiro M. Revisiting the indications for liver transplantation in cirrhotic patients considering the long-term outcomes of cirrhotic patients J Hepatobiliary Pancreat Sci 10.1002/jhbp.777
- Aoki T, Yamada A, Kato Y, Saito H, Tsuboi A, Nakada A, Niikura R, Fujishiro M, Oka S, Ishihara S, Matsuda T, Nakahori M, Tanaka S, Koike K, Tada T. Automatic detection of blood content in capsule endoscopy images based on a deep convolutional neural network J Gastroenterol Hepatol 10.1111/jgh.14941
- Kuzuya T, Ishigami M, Ito T, Ishizu Y, Honda T, Ishikawa T, Fujishiro M. Favorable radiological antitumor response at 2 weeks after starting lenvatinib for patients with advanced hepatocellular carcinoma Hepatol Res 10.1111/hepr.13452
- Goto O, Oyama T, Ono H, Takahashi A, Fujishiro M, Saito Y, Abe S, Kaise M, Iwakiri K, Yahagi N. Endoscopic hand-suturing is feasible, safe, and may reduce bleeding risk after gastric endoscopic submucosal dissection: a multicenter pilot study (with video) Gastrointest Endosc 10.1016/j.gie.2019.12.046
- Ito T, Ishigami M, Ishizu Y, Kuzuya T, Honda T, Ishikawa T, Toyoda H, Kumada T, Fujishiro M. Serum Nutritional Markers as Prognostic Factors for Hepatic and Extrahepatic Carcinogenesis in Japanese Patients with Nonalcoholic Fatty Liver Disease Nutr Cancer 10.1080/01635581.2019.1653474
- Kuzuya T, Ishigami M, Ito T, Ishizu Y, Honda T, Ishikawa T, Fujishiro M. Sorafenib vs. Lenvatinib as First-line Therapy for Advanced Hepatocellular Carcinoma With Portal Vein Tumor Thrombosis Anticancer Res 10.21873/anticanres.14193
- Aoki T, Yamada A, Aoyama K, Saito H, Fujisawa G, Odawara N, Kondo R, Tsuboi A, Ishibashi R, Nakada A, Niikura R, Fujishiro M, Oka S, Ishihara S, Matsuda T, Nakahori M, Tanaka S, Koike K, Tada T. Clinical usefulness of a deep learning-based system as the first screening on small-bowel capsule endoscopy reading Dig Endosc 10.1111/den.13517
- Saito H, Aoki T, Aoyama K, Kato Y, Tsuboi A, Yamada A, Fujishiro M, Oka S, Ishihara S, Matsuda T, Nakahori M, Tanaka S, Koike K, Tada T. Automatic detection and classification of protruding lesions in wireless capsule endoscopy images based on a deep convolutional neural network Gastrointest Endosc 10.1016/j.gie.2020.01.054
- Tsuboi A, Oka S, Aoyama K, Saito H, Aoki T, Yamada A, Matsuda T, Fujishiro M, Ishihara S, Nakahori M, Koike K, Tanaka S, Tada T. Artificial intelligence using a convolutional neural network for automatic detection of small-bowel angioectasia in capsule endoscopy images Dig Endosc 10.1111/den.13507
- Kawakubo M, Tanaka M, Ochi K, Watanabe A, Saka-Tanaka M, Kanamori Y, Yoshioka N, Yamashita S, Goto M, Itoh M, Shirakawa I, Kanai S, Suzuki H, Sawada M, Ito A, Ishigami M, Fujishiro M, Arima H, Ogawa Y, Suganami T. Dipeptidyl peptidase-4 inhibition prevents nonalcoholic steatohepatitis-associated liver fibrosis and tumor development in mice independently of its anti-diabetic effects Sci Rep 10.1038/s41598-020-57935-6
- Suzuki H, Yamamura T, Fujishiro M. Endoscopic detorsion using single-balloon endoscopy for cecal volvulus Dig Endosc 10.1111/den.13558
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