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病態内科学消化器内科

研究室概要

当科は消化器のすべての疾患の診療を日本のトップレベルの知識と技術で行っています。医局員を消化管(上部、下部)、肝臓、胆膵の3グループに分け、臨床では上部、下部、胆膵グループは、主に新しい内視鏡診断・治療技術の導入と開発、肝臓グループではウイルス肝炎、肝硬変、肝癌の新規治療に取り組んでおります。また、研究では、各グループの研究に加えて、栄養あるいは腸内細菌の研究に関しては、小腸や大腸のみでなく膵臓、肝臓を含めた多臓器から取り組んでいます。このように当科では今までの伝統をさらに発展させた臨床・研究、あるいは新しく立ち上げた臨床・研究に若い医師が積極的に取り組んでいます。更にグローバル化の一つとして2012年よりメコン5か国（ベトナム）、ラオス、カンボジア、タイ、ミャンマー）での内視鏡技術向上のために、内視鏡トレーニングセンターなどを設立し国家プロジェクトとして貢献しておりますし、外国との共同研究も積極的に行っております。

研究プロジェクト

消化管グループ

上部消化管グループでは、現在咽喉頭から十二指腸までの消化管を対象とした診療・研究を行っています。診療では、消化管早期がんの内視鏡診断(NBI, BLI, 超拡大内視鏡, EUS)・治療(ELPS, EMR, ESD, EMRO, PDT, LECS)に力をいれています。また、現在までに下記の研究を行なっています。

AI関連

  • ・食道・胃病変の指摘および診断に対する人工知能技術を用いたコンピュータ支援医用画像診断システムの開発。
  • ・超音波内視鏡に対する人工知能を用いた上部消化管粘膜下腫瘍の画像診断支援システムの開発研究。
  • ・Deep learningを用いた食道表在癌の深達度診断

腸内細菌関連

  • ・ヘリコバクターピロリ菌除菌前後における腸内細菌叢の変化。
  • ・消化管腫瘍患者における口腔内・腸内細菌叢の構成および機能の変化との関連。
  • ・早期胃癌ESD症例に対するケストース療法による栄養状態および腸内細菌叢の変化。

ESD関連

  • ・高齢者胃癌ESD後の長期予後に関連する患者因子の研究
  • ・８０歳以上の食道表在癌、早期胃癌患者に対する治療選択システムの確立（多施設共同試験）
  • ・ESD適応の表在型食道扁平上皮癌患者に対して、経過観察例も含めて長期予後予測因子を同定することで、治療方針として「ESDを行わない、経過観察」という選択肢の可能性を探る研究。
  • ・抗血栓薬内服症例における胃ESD後出血リスク因子の解析およびリスク低減のための工夫。
  • ・十二指腸非乳頭部腫瘍に対する内視鏡治療の適応・治癒基準の検討および安全・確実なESD方法の開発。

診断法関連

  • ・High resolution manometry (HRM)を用いた糖尿病性蠕動障害の頻度とその病態の解明。
  • ・EUSおよびHRMを用いた好酸球性食道炎患者における自覚症状の客観的評価方法の研究。
  • ・好酸球性食道炎に対する超拡大内視鏡を用いた食道好酸球増多や活動性の評価と、optical biopsyとしての有用性の検討。
  • ・胃悪性リンパ腫の画像診断および適切なフォローアップ方法の確立。
  • ・咽頭腫瘍、十二指腸乳頭部腫瘍に対する超拡大観察を用いた診断法の確立。
  • ・十二指腸非乳頭部腫瘍に対する超拡大内視鏡を用いた観察における至適染色法の検討および良悪性鑑別のための診断基準の確立。
  • ・十二指腸非乳頭部腫瘍に対する治療選択を見据えた白色光・画像強調内視鏡を用いた効率的な診断法の確立。

下部消化管領域(小腸・大腸)では臨床業務(研究)・基礎研究・臨床検体を用いた基礎的病態解析を柱として日々の診療を行っています。

1) 臨床研究

主に小腸疾患、炎症性腸疾患(IBD)、大腸腫瘍、機能性腸疾患などを対象とした研究を進めております。小腸は検査のしづらさから近年まで「暗黒大陸」と呼ばれていましたが、当院では小腸カプセル内視鏡・小腸バルーン内視鏡を開発当初より取り入れ、小腸疾患の内視鏡的な診断・managementに関して、様々な報告をしてきました。また、炎症性腸疾患では、小腸に対する検査を得意とすることの強みを生かして、クローン病の小腸病変に関する様々な報告をしています。炎症性腸疾患ではその他に、微量元素や亜鉛の欠乏と病態との相関も臨床研究をすすめています。
大腸腫瘍の内視鏡治療は、巨大病変、線維化症例、治療後再発症例、虫垂病変、UC関連腫瘍などの治療困難症例に対しても積極的に行っています。また、画像強調内視鏡やEUSを用いて診断精度の向上を目指した研究をしています。また、機能性腸疾患に対しては、新たな治療法の開発を目指し、FMT(糞便移植)そのほかの新規治療薬の効果を検証する臨床試験を行っています。また他施設との共同研究なども積極的に参加しています。

2) 臨床検体を用いた基礎的病態解析

早期大腸癌とIBD関連大腸癌の臨床病理学的・分子生物学的因子の検討を行っています。早期大腸癌ではESD治療後、一定の病理学的基準を満たさない場合はリンパ節転移のリスクを懸念して追加手術が推奨されますが、実際のリンパ節転移は低率であり、我々は新たなリスク因子の探索を目指しています。
また、IBD関連大腸癌は通常の大腸癌と異なるpathwayによる炎症性発癌とされていますが、病変自体が不明瞭で内視鏡による早期発見が困難な場合が多く、また通常の大腸癌と判別困難な場合もあります。我々は、大腸癌のESD検体や手術検体などを用いて、免疫組織化学染色による病理学的検討や、次世代シーケンサーによる遺伝子解析などを行い、早期発見に有用な因子や予後予測因子の検討を行っています。

3} 基礎研究

1. 炎症性腸疾患（IBD）における病態の解明を目指して、臨床検体やマウスモデルを用いた解析を行っています。腸管には、上皮細胞、腸内細菌、免疫細胞、間葉系細胞という多様な細胞群が存在し、相互作用することで腸管の恒常性を維持しています。その中でも、上皮細胞の機能に着目し、その機能の破綻や相互作用の異常がどのようにIBDの病態と関連するかを解析しています。また、IBDの合併症である腸管線維化や腸炎関連大腸癌の病態についても研究も進めています。

2. がん抑制性機能を有するがん抑制性線維芽細胞を特異的に標識するマーカー分子Meflinを世界に先駆けて同定しました。また、がんの進行に伴って、Meflin陽性線維芽細胞（善玉）が、Meflin陰性線維芽細胞（悪玉）に形質転換することも明らかにしました。 “悪玉”線維芽細胞を“善玉”線維芽細胞に戻す（形質転換させる）ことができれば、それはがんのみならず多くの疾患の治療法になることが期待されます。現在新規概念である線維芽細胞の形質転換療法を開発するための医師主導治験（対象：膵がん）を2021年から予定していますし、IBDへの応用も模索しています。

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胆膵グループ

1) 超音波を用いた新しい胆道・膵臓疾患の診断法の開発

腹部超音波検査・超音波内視鏡検査（EUS）に超音波造影剤（当院IRBの承認すみ）やエラストグラフィ（strain法、shear wave法）、空間位置情報を加味したGPS機能、CT-fusion機能、３D超音波などの新しいモダリティーを積極的に導入し、最新の診断をおこなっています。また内視鏡下や超音波内視鏡下穿刺生検（EUS-FNA）下に得られた胆道・膵臓疾患の検体（組織や膵液など）を用いて分子生物学的な診断や治療に有用な結果を目指した研究をしています。

膵腫瘤性病変に対する造影EUS
膵腫瘤性病変に対するEUSエラストグラフィ（Strain法）

2) 切除不能膵癌に対する新たな治療方法の開発

予後の悪い切除不能膵癌に対する新たな治療法として腫瘍病理と協力して新たな治療法を開発、医師主導治験を目指しています。

3) 十二指腸乳頭部腫瘍の内視鏡診断と治療

内視鏡的逆行性胆管膵管造影（ERCP）や、管腔内超音波検査（IDUS）などを用いて十二指腸乳頭部腫瘍の進展範囲を詳細に診断し、より侵襲が少なく、偶発症の少ない内視鏡的乳頭切除術を施行しています。

4) 胆道疾患の経十二指腸乳頭的診断と治療

管腔内超音波検査（IDUS）、経乳頭的胆管生検などを積極的に施行し、より侵襲が少なく確実な診断を目指して研究しています。また、総胆管結石や閉塞性黄疸に対し、適切な切石法やドレナージ法を選択することにより低侵襲で確実な治療を施行しています。

5) 膵管内乳頭粘液性腫瘍（IPMN）をはじめとした膵嚢胞性疾患の診断法の開発、自然史解明への研究

造影超音波内視鏡や内視鏡的胆管膵管造影（ERCP）をはじめとした各種画像診断技術を駆使し、既存の診断法よりも侵襲が少なく確実な膵嚢胞の診断治療、開発を行っています。また膵嚢胞性疾患の経過観察を長期間行うことにより、膵嚢胞性疾患の自然史解明に向けた多施設共同研究を行っています。

6) 自己免疫性膵炎の診断・治療・自然史に関する研究

自己免疫性膵炎（AIP）はその発生に免疫学的機序が関与する特殊な膵炎です。AIPは膵癌との鑑別を要する画像所見を呈し、その診断において病理学的所見は重要な位置を占めます。名古屋大学ではAIPを疑う患者さんに対して超音波内視鏡下穿刺生検（EUS-FNA）を積極的に施行しています。得られた検体を詳細に解析し、AIP診断に対する、低侵襲かつ安全な組織学的診断法であるEUS-FNAの有用性を研究しています。またAIPはステロイド治療に反応し、短期予後は良好とされていますが、長期予後については不明な点が多く残されています。現在AIP症例を集積し、再燃の予測因子、内外分泌能の予後、悪性腫瘍の合併など長期的な臨床像の検討を行っています。

AIPの画像診断
AIP患者さんから採取したEUS-FNA検体

7) 栄養の消化吸収を担う、膵・小腸臓器相関、腸内細菌叢と病態の解明

改良型小腸内視鏡試作機を使用することで、低侵襲な近位小腸までの内視鏡観察が可能となりました。膵疾患例を中心に小腸絨毛形態および機能の評価を行い、消化吸収の主座となる膵と小腸の臓器相関について研究しています。また次世代シーケンサーを用いて、糞便などから得られた腸内細菌叢を解析し、種々の疾患・病態との相関を研究しています。

8) AIを用いたEUS診断

近年、消化器内視鏡画像を用いた人工知能(artificial intelligence；以下AI)での診断の有用性が報告されその動向が注目されています。一方、胆膵領域における超音波内視鏡（EUS）の進歩は目覚ましく、画質の向上は基より、組織の硬さを測定するEUSエラストグラフィ、血行動態を詳細に評価する造影EUS、EUS観察下に組織を採取するEUSガイド下穿刺生検などEUSを用いた様々な新規技術が登場し、胆膵疾患診療において、なくてはならない手技となっています。しかしながらEUSは主観性の高い検査であり、術者の技術や経験によるところも大きいという問題があります。現在、EUS診断の客観性、正確性を高めるため、工学系の研究者と協力してAI診断の研究をしています。

9) 抗がん剤の浸透性を改善し、間質による薬剤到達障害を解消する新たな治療の開発

膵臓がんは、消化器系のがんの中でも特に治療が難しいがんの一つです。これは、がんの早期発見が難しく、抗がん剤に対する効果が限られているためです。顕微鏡で膵臓がんの組織を観察すると、がん細胞の塊である腫瘍の大部分（約90%）ががん細胞以外の「間質」と呼ばれる領域で構成されていることが確認できます。この間質部分には、「がん関連線維芽細胞（CAF）」が豊富に存在し、線維化を促進して腫瘍内の圧力を高めることで、血管を圧迫し抗がん剤が腫瘍の奥深くまで届きにくくなります。この現象は「間質による薬剤到達障害」と呼ばれ、膵臓がん治療の効果を低下させる主要な要因とされています。
最近の研究では、CAFにはがんの進行を促進するタイプ（pCAF）と進行を抑制するタイプ（rCAF）が存在することが提唱されるようになりました。2019年、我々の研究チームはrCAFのマーカーとして「Meflin」を世界に先駆けて特定しました。Meflinは線維化を引き起こすメカニズムを抑制し、がんの進行を遅らせることに寄与します。また、がんが進行するとMeflinを発現するrCAFがMeflinを発現しないpCAFに変化することも明らかになりました。この悪玉のpCAFを善玉のrCAFに変換することで、抗がん剤の浸透性を改善し、間質による薬剤到達障害を解消する新たな治療可能性が開けると考えられています。
この成果に基づき、現在、切除不能な膵臓がん患者を対象にした医師主導のMIKE-1治験が行われています。この治験では、標準治療と併せてMeflinの発現を促進する薬剤「Am80」が使用され、その有効性と安全性が評価されています。
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肝臓グループ

1)名古屋大学医学部消化器内科を中心とした肝臓病学多施設臨床研究グループの立ち上げ

名古屋大学消化器内科には約50の関連病院があり、これらの関連病院と共同で広く「肝疾患の病態解明とエビデンス構築」を目指した臨床研究グループを立ち上げることとしました。

2)　ウイルス性肝炎における病態の解明

i) C型肝炎ウイルス(HCV)　現在当院を中心として、インターフェロン(IFN)ベース治療後の新たなフリーDirect Acting Antiviral(DAA)併用治療に関しての多施設共同研究を施行、治療効果、安全性、治療効果に関与する因子の探索的検討を施行しています。特に我々は現在までにIFNベース治療とIL28B宿主遺伝子多型、HCV core領域、NS5A領域と病態、および治療効果について明らかにしてきました。現在IFNフリー治療においてもこれらの検討、およびウイルス消失による免疫反応の動態解析も行っています。また、インターフェロンフリー治療により増加したSVR後の病態についても検討を行っています。
ii) B型肝炎ウイルス(HBV)　HBVはHCVと比較して複雑な生活環を持ち宿主肝細胞の核内にcccDNAとして安定した形で存在するため、根治療法の開発が困難とされています。我々は現在、臨床的寛解状態と考えられるHBs抗原消失とHBV core領域の変異との関係、また現在標準治療として使用されている核酸アナログ製剤で血中HBV DNA陰性化が得られている症例において、血清マーカー(HBs抗原、HBコア関連抗原)の値と病態との関係、また発癌に関与する因子の検討などを行っています。

3) 急性肝不全動物モデルにおける炎症と再生の相関

肝不全に対して直接肝再生を促す確立された方法がない現状で、我々はそれを解決する方策の有力な候補の一つとして、口腔外科との共同研究で歯髄由来の幹細胞培養上清を用い、それを急性肝不全モデル動物に投与することで効果を示すことを明らかにしてきました。現在その培養上清中に強い効果を示す因子を同定し、その抗炎症作用、肝再生促進作用について検討し、肝再生には強力な抗炎症との相関が不可欠であることを見出すべく検討を進めています。

4)非アルコール性脂肪性肝疾患（NAFLD）/非アルコール性脂肪性肝炎（NASH）患者の予後の検討及び
動物モデルにおける各種治療薬の治療効果の検討

NAFLD、特に肝硬変・肝癌に至る可能性のあるNASHは増加の一途を辿っており、問題となっている。このようなNAFLD、NASH患者に関する特徴や予後の臨床的検討を行っています。を行っています。またNASH及びNASHベースの肝硬変や肝癌を発症するマウスモデルにおいて各種薬剤を投与することにより肝臓の炎症、線維化、脂肪蓄積などの改善、さらには発癌抑制効果や腸内細菌との関係について検討し、その機序を明らかにする研究を行っています。

5)肝疾患と腸内細菌叢の相関

各種肝疾患と腸内細菌叢の相関について、次世代シーケンサー(NGS)により腸内細菌叢を解析検討しています。特に、肝硬変及び肝癌における腸内細菌叢の特徴を明らかにする研究を行っています。プレバイオティクスによりNASH/NAFLDの改善をみる前向きの無作為比較試験も行っています。

6)サルコペニアと肝硬変の関連性

肝硬変患者において、サルコペニア（筋肉量、筋量が低下した状態）が予後不良因子であること、QOL増悪因子であることを明らかにしてきた。現在はサルコペニアに対する運動療法の開発を行い、肝硬変患者の予後延長に繋がるか検討を行っています。さらに基礎研究として、腸内細菌叢とサルコペニアに関する研究も行っています。

7)門脈圧亢進症に対する病態の評価および治療に関する解析

門脈圧亢進症は肝硬変に由来する代表的な合併症であり、それに伴う食道胃静脈瘤出血や腹水貯留などは患者の生命予後やQOLを悪化させる要因です。近年B型肝炎やC型肝炎に対する抗ウイルス療法は進歩していますが。高度に肝線維化が進展した症例や増加する非アルコール性脂肪性肝炎症例などの存在により、門脈圧亢進症のマネジメントは依然として肝疾患診療における重要な課題です。

8)免疫チェックポイント阻害薬による免疫関連有害事象

現在のがん治療の中心的薬剤の一つである免疫チェックポイント阻害薬による免疫関連有害事象（irAE）としての肝障害の発症メカニズムを解明し、その発症予測と効率的な治療アルゴリズムを開発することを目的として、バイオマーカー探索研究を行っております。

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教員

構成員名役職所属
川嶋 啓揮 教授 消化器内科
中村 正直 准教授 光学診療部/消化器内科（消化管）
本多 隆 講師 消化器内科（肝臓）
古川 和宏 講師 消化器内科（消化管）
石川 卓哉 講師 消化器内科（胆膵）
石津 洋二 病院講師 消化器内科（肝臓）
山村 健史 病院講師 消化器内科（消化管）
前田　啓子 助教 消化器内科（消化管）
今井　則博 助教 光学診療部（肝臓）
伊藤　隆徳 助教 消化器内科（肝臓）
山雄　健太郎 助教 光学診療部（胆膵）
澤田　つな騎 病院助教 光学診療部（消化管）
田中　卓 病院助教 救急科(肝臓)
水谷　泰之 病院助教 消化器内科（胆膵）
石川　恵里 病院助教 消化器内科（消化管）
山本　健太 病院助教 光学診療部（肝臓）
横山　晋也 病院助教 消化器内科（肝臓）
飯田　忠 病院助教 消化器内科（胆膵）
村手 健太郎 病院助教 消化器内科（消化管）
廣瀬　崇 病院助教 消化器内科（消化管）
植月　康太 病院助教 消化器内科（胆膵）
水野　和幸 病院助教 化学療法部(肝臓)

研究実績

  • 2023年
    1. Kawashima H, Ishikawa T, Yamao K, Mizutani Y, Iida T, Uetsuki K, Yamamura T, Furukawa K, Nakamura M.Current status of and future issues related to endoscopic papillectomyNagoya J Med Sci. 2023 Nov;85(4):648-658. doi: 10.18999/nagjms.85.4.648.
    2. Furune S, Suzuki T, Honda T, Yamamoto K, Furukawa K, Nakamura M, Ishigami M, Kinoshita F, Kadota Y, Tochio T, Shimomura Y, Hirooka Y, Fujishiro M, Kawashima H.Effects of 1-kestose on microbiome changes caused by vonoprazan: a randomized, double-blind, placebo-controlled pilot studyJ Gastroenterol Hepatol. 2023 Dec 27. doi: 10.1111/jgh.16445. Online ahead of print.
    3. Ikegami S, Maeda K, Urano T, Mu J, Nakamura M, Yamamura T, Sawada T, Ishikawa E, Yamamoto K, Muto H, Oishi A, Iida T, Mizutani Y, Ishikawa T, Kakushima N, Furukawa K, Ohno E, Honda T, Ishigami M, Kawashima H.Monoclonal Antibody Against Mature Interleukin-18 Ameliorates Colitis in Mice and Improves Epithelial Barrier FunctionInflamm Bowel Dis. 2023 Dec 23:izad292. doi: 10.1093/ibd/izad292. Online ahead of print.
    4. Furukawa K, Furune S, Hirose T, Kawashima H.Suturing of a mucosal defect after gastric endoscopic submucosal dissection using a combination of an anchor pronged clip and conventional clipsRev Esp Enferm Dig. 2023 Dec 14. doi: 10.17235/reed.2023.10120/2023. Online ahead of print.
    5. Furukawa K, Furune S, Hirose T, Kawashima H.Endoscopic submucosal dissection using a novel thin-therapeutic endoscope for superficial esophageal squamous cell carcinoma with severe stricture at the pharyngoesophageal junctionRev Esp Enferm Dig. 2023 Dec 14. doi: 10.17235/reed.2023.10118/2023. Online ahead of print.
    6. Ito N, Tajika M, Tanaka T, Yamada K, Takagi A, Onishi S, Abe T, Higaki E, Fujieda H, Inaba Y, Muro K, Kawashima H, Niwa Y.Skeletal Muscle Quality and Quantity Affect Prognosis after Neoadjuvant Chemotherapy with a Triple Regimen of Docetaxel/Cisplatin/5-FU in Patients with Esophageal CancerJ Clin Med. 2023 Oct 25;12(21):6738. doi: 10.3390/jcm12216738.
    7. Nakanishi K, Tanaka C, Kanda M, Miyata K, Furukawa K, Maeda O, Shimizu D, Sugita S, Kakushima N, Furune S, Kawashima H, Ando Y, Ebata T, Kodera Y.Low Expectancy of Conversion Surgery with R0 Resection in Patients with CEA > 5.0 ng/mL at the Initial RECIST Evaluation for Metastatic Gastric CancerCancers (Basel). 2023 Oct 29;15(21):5197. doi: 10.3390/cancers15215197.
    8. Ishikawa T, Yamao K, Mizutani Y, Iida T, Kawashima H.Cutting edge of endoscopic ultrasound-guided fine-needle aspiration for solid pancreatic lesionsJ Med Ultrason (2001). 2023 Nov 1. doi: 10.1007/s10396-023-01375-y. Online ahead of print.
    9. Uchida G, Nakamura M, Yamamura T, Maeda K, Sawada T, Ishikawa E, Furukawa K, Iida T, Mizutani Y, Yamao K, Ishikawa T, Ishizu Y, Honda T, Ishigami M, Kawashima H.Real-World Effectiveness and Risk Factors for Discontinuation of Ustekinumab in Ulcerative ColitisInflamm Intest Dis. 2023 Jun 14;8(2):60-68. doi: 10.1159/000531497. eCollection 2023 Oct.
    10. Ishiwatari H, Kawabata T, Kawashima H, Nakai Y, Miura S, Kato H, Shiomi H, Fujimori N, Ogura T, Inatomi O, Kubota K, Fujisawa T, Takenaka M, Mori H, Noguchi K, Fujii Y, Sugiura T, Ideno N, Nakafusa T, Masamune A, Isayama H, Sasahira N.Endoscopic nasobiliary drainage versus endoscopic biliary stenting for preoperative biliary drainage in patients with malignant hilar biliary obstruction: Propensity score-matched multicenter comparative studyDig Endosc. 2023 Oct 27. doi: 10.1111/den.14712. Online ahead of print.
    11. Yokoyama S, Ishizu Y, Honda T, Imai N, Ito T, Yamamoto K, Muto H, Shirota C, Tainaka T, Sumida W, Makita S, Takada S, Nakagawa Y, Maeda T, Nakamura M, Ishigami M, Uchida H, Kawashima H.A new criterion including the aspartate aminotransferase-to-platelet ratio index and liver and spleen stiffness to rule out varices needing treatment in children with biliary atresia: Modification of the Baveno VII criteriaHepatol Res. 2023 Oct 16. doi: 10.1111/hepr.13976. Online ahead of print.
    12. Uchida G, Nakamura M, Yamamura T, Tsuzuki T, Kawashima H.Real-world effectiveness of ustekinumab for patients with ulcerative colitis: a systematic review and meta-analysisNagoya J Med Sci. 2023 Aug;85(3):402-427. doi: 10.18999/nagjms.85.3.402.
    13. Chau A, Yeh ML, Tsai PC, Huang DQ, Kim SE, Trinh H, Yoon EL, Oh H, Jeong JY, Ahn SB, An J, Tseng CH, Hsu YC, Jeong SW, Cho YK, Shim JJ, Kim HS, Ito T, Marciano S, Kawashima K, Suzuki T, Watanabe T, Nozaki A, Ishikawa T, Inoue K, Eguchi Y, Uojima H, Abe H, Takahashi H, Chuma M, Ishigami M, Hoang JK, Maeda M, Huang CF, Gadano A, Dai CY, Huang JF, Tanaka Y, Chuang WL, Lim SG, Cheung R, Yu ML, Jun DW, Nguyen MH.Sex Differences in Treatment Response to Nucleos(t)ide Therapy in Chronic Hepatitis B: A Multicenter Longitudinal StudyClin Gastroenterol Hepatol. 2023 Sep 19:S1542-3565(23)00713-9. doi: 10.1016/j.cgh.2023.09.002. Online ahead of print.
    14. Murakami M, Onishi S, Yamada K, Ogawa K, Yokoyama S, Kurashima Y, Miyano G, Ishimaru T, Kawashima H, Uchida H, Yamataka A, Okuyama H, Ieiri S.How many cases do instructor class pediatric surgeons need to experience to be an independent operator in performing advanced endoscopic surgery? A nationwide survey to establish an ideal curriculum for pediatric endoscopic surgery in JapanPediatr Surg Int. 2023 Sep 9;39(1):271. doi: 10.1007/s00383-023-05550-7.
    15. Sugiyama Y, Yamamoto K, Honda T, Kato A, Muto H, Yokoyama S, Ito T, Imai N, Ishizu Y, Nakamura M, Asano T, Enomoto A, Zaitsu K, Ishigami M, Fujishiro M, Kawashima H.Impact of elobixibat on liver tumors, microbiome, and bile acid levels in a mouse model of nonalcoholic steatohepatitisHepatol Int. 2023 Dec;17(6):1378-1392. doi: 10.1007/s12072-023-10581-2. Epub 2023 Sep 4.
    16. Nakamura M, Yamamura T, Maeda K, Sawada T, Ishikawa E, Furukawa K, Iida T, Mizutani Y, Yamao K, Ishikawa T, Honda T, Ishigami M, Kawashima H.Clinical characteristics of Dieulafoy's lesion in the small bowel diagnosed and treated by double-balloon endoscopyBMC Gastroenterol. 2023 Aug 24;23(1):290. doi: 10.1186/s12876-023-02913-1.
    17. Ito T, Morooka H, Takahashi H, Fujii H, Iwaki M, Hayashi H, Toyoda H, Oeda S, Hyogo H, Kawanaka M, Morishita A, Munekage K, Kawata K, Tsutsumi T, Sawada K, Maeshiro T, Tobita H, Yoshida Y, Naito M, Araki A, Arakaki S, Kawaguchi T, Noritake H, Ono M, Masaki T, Yasuda S, Tomita E, Yoneda M, Tokushige A, Ishigami M, Kamada Y, Ueda S, Aishima S, Sumida Y, Nakajima A, Okanoue T; Japan Study Group of Nonalcoholic Fatty Liver Disease (JSG-NAFLD).Identification of clinical phenotypes associated with poor prognosis in patients with nonalcoholic fatty liver disease via unsupervised machine learningJ Gastroenterol Hepatol. 2023 Oct;38(10):1832-1839. doi: 10.1111/jgh.16326. Epub 2023 Aug 19.
    18. Park H, Yoon EL, Ito T, Jo AJ, Kim M, Lee J, Kim HL, Arai T, Atsukawa M, Kawanaka M, Toyoda H, Ishigami M, Yu ML, Jun DW, Nguyen MH.Diagnostic Performance of the Fibrosis-4 Index and Nonalcoholic Fatty Liver Disease Fibrosis Score in Lean Adults With Nonalcoholic Fatty Liver DiseaseJAMA Netw Open. 2023 Aug 1;6(8):e2329568. doi: 10.1001/jamanetworkopen.2023.29568.
    19. Matsuda N, Imai N, Yokoyama S, Yamamoto K, Ito T, Ishizu Y, Honda T, Okamoto S, Kanematsu T, Suzuki N, Matsushita T, Ishigami M, Kawashima H.Clinical course and prognosis of patients with hepatocellular carcinoma and haemophiliaEur J Gastroenterol Hepatol. 2023 Oct 1;35(10):1211-1215. doi: 10.1097/MEG.0000000000002628. Epub 2023 Aug 14.
    20. Takahashi H, Ohno E, Furukawa T, Yamao K, Ishikawa T, Mizutani Y, Iida T, Shiratori Y, Oyama S, Koyama J, Mori K, Hayashi Y, Oda M, Suzuki T, Kawashima H.Artificial intelligence in a prediction model for postendoscopic retrograde cholangiopancreatography pancreatitisDig Endosc. 2023 Jul 13. doi: 10.1111/den.14622. Online ahead of print.
    21. Mizuno K, Imai N, Yamamoto T, Yokoyama S, Yamamoto K, Ito T, Ishizu Y, Honda T, Kuzuya T, Ishigami M, Kawashima H.Pretreatment Proteinuria Predicts the Prognosis of Patients Receiving Systemic Therapy for Unresectable Hepatocellular CarcinomaCancers (Basel). 2023 May 21;15(10):2853. doi: 10.3390/cancers15102853.
    22. Kataoka K, Ishikawa T, Ohno E, Yamao K, Mizutani Y, Iida T, Kato K, Kinoshita F, Yamamura T, Furukawa K, Nakamura M, Kawashima H.Randomized trial comparing 15 vs 5 actuations per pass during endoscopic ultrasound-guided fine-needle biopsy for specimen acquisition of solid pancreatic lesionsJ Gastroenterol Hepatol. 2023 Sep;38(9):1647-1655. doi: 10.1111/jgh.16258. Epub 2023 Jun 16.
    23. Wong YJ, Tran S, Huang CF, Hsu YC, Preda C, Toyoda H, Liu J, Jun DW, Landis C, Huang DQ, Gila A, Negoita L, Yasuda S, Tseng CH, Tsai PC, Uojima H, Nozaki A, Chuma M, Atsukawa M, Ishigami M, Itokawa N, Iio E, Lam CP, Watanabe T, Asai A, Yokohama K, Abe H, Enomoto M, Kawada N, Tamori A, Lee DH, Jun MJ, Do S, Vo DKH, Liu L, Li J, Ji F, Wang W, Li Y, Wang X, Guo F, Xu Q, Jing L, Ye Q, Pan H, Zhang J, Wen X, Wang Q, Ren H, Cai D, Shang J, Liu J, Lu C, Zang W, Li J, Niu J, Zhang M, Wu C, Huang R, Maeda M, Nakanishi A, Yeh ML, Chuang WL, Huang JF, Dai C, Ishikawa T, Takaguchi K, Senoh T, Trinh HN, Takahashi H, Eguchi Y, Quek SXZ, Haga H, Ogawa E, Wong G, Buti M, Fukunishi S, Ueno Y, Yuen MF, Tanaka Y, Lim SG, Cheung R, Yu ML, Nguyen MH.Real-world treatment outcome with protease inhibitor direct-acting antiviral in advanced hepatitis C cirrhosis: a REAL-C studyHepatol Int. 2023 Oct;17(5):1150-1161. doi: 10.1007/s12072-023-10547-4. Epub 2023 Jun 5.
    24. Huang DQ, Tran A, Yeh ML, Yasuda S, Tsai PC, Huang CF, Dai CY, Ogawa E, Ishigami M, Ito T, Kozuka R, Enomoto M, Suzuki T, Yoshimaru Y, Preda CM, Marin RI, Sandra I, Tran S, Quek SXZ, Khine HHTW, Itokawa N, Atsukawa M, Uojima H, Watanabe T, Takahashi H, Inoue K, Maeda M, Hoang JK, Trinh L, Barnett S, Cheung R, Lim SG, Trinh HN, Chuang WL, Tanaka Y, Toyoda H, Yu ML, Nguyen MH.Antiviral therapy substantially reduces HCC risk in patients with chronic hepatitis B infection in the indeterminate phaseHepatology. 2023 Nov 1;78(5):1558-1568. doi: 10.1097/HEP.0000000000000459. Epub 2023 May 16.
    25. Yamamoto T, Mizuno K, Ito T, Yokoyama S, Yamamoto K, Imai N, Ishizu Y, Honda T, Ishikawa T, Kanamori A, Yasuda S, Toyoda H, Yokota K, Hase T, Nishio N, Maeda O, Ishii M, Sone M, Ando Y, Akiyama M, Ishigami M, Kawashima H.Abdominal pain accompanied by elevated serum inflammatory markers and biliary enzymes for diagnosing immune checkpoint inhibitor-induced sclerosing cholangitisInvest New Drugs. 2023 Jun;41(3):512-521. doi: 10.1007/s10637-023-01366-3. Epub 2023 May 12.
    26. Ikegami S, Nakamura M, Honda T, Kawashima H.Letter: 1-kestose, the smallest fructooligosaccharide component, protection for mild to moderate ulcerative colitis patients-authors' replyAliment Pharmacol Ther. 2023 Jun;57(11):1351-1352. doi: 10.1111/apt.17443.
    27. Imai N, Ohsaki Y, Cheng J, Zhang J, Mizuno F, Tanaka T, Yokoyama S, Yamamoto K, Ito T, Ishizu Y, Honda T, Ishigami M, Wake H, Kawashima H.Distinct features of two lipid droplets types in cell nuclei from patients with liver diseasesSci Rep. 2023 Apr 26;13(1):6851. doi: 10.1038/s41598-023-33977-4.
    28. Guo Y, Hinoki A, Deie K, Tainaka T, Sumida W, Makita S, Okamoto M, Takimoto A, Yasui A, Takada S, Nakagawa Y, Kato D, Maeda T, Amano H, Kawashima H, Uchida H, Shirota C.Anastomotic time was associated with postoperative complications: a cumulative sum analysis of thoracoscopic repair of tracheoesophageal fistula in a single surgeon's experienceSurg Today. 2023 Dec;53(12):1363-1371. doi: 10.1007/s00595-023-02687-9. Epub 2023 Apr 23.
    29. Yamauchi R, Ito T, Yoshio S, Yamamoto T, Mizuno K, Ishigami M, Kawashima H, Yasuda S, Shimose S, Iwamoto H, Yamazoe T, Mori T, Kakazu E, Kawaguchi T, Toyoda H, Kanto T.Serum osteopontin predicts the response to atezolizumab plus bevacizumab in patients with hepatocellular carcinomaJ Gastroenterol. 2023 Jun;58(6):565-574. doi: 10.1007/s00535-023-01985-w. Epub 2023 Mar 30.
    30. Muto H, Honda T, Tanaka T, Yokoyama S, Yamamoto K, Ito T, Imai N, Ishizu Y, Maeda K, Ishikawa T, Adachi S, Sato C, Tsuji NM, Ishigami M, Fujishiro M, Kawashima H.Proteomic Analysis Reveals Changes in Tight Junctions in the Small Intestinal Epithelium of Mice Fed a High-Fat DietNutrients. 2023 Mar 19;15(6):1473. doi: 10.3390/nu15061473.
    31. Kurata N, Shizuku M, Jobara K, Ishizu Y, Ishigami M, Ogura Y.A Successful Living Donor Liver Transplantation Using Hepatic Iron Deposition Graft Suspected by Magnetic Resonance ImagingCase Rep Transplant. 2023 Mar 16;2023:9075184. doi: 10.1155/2023/9075184. eCollection 2023.
    32. Tanaka H, Kakushima N, Muroi K, Hirose T, Suzuki T, Suzuki T, Hida E, Hirai K, Shibata H, Ito N, Furune S, Furukawa K, Fujishiro M.Successful prevention of stenosis after circumferential endoscopic resection of esophageal cancerNagoya J Med Sci. 2023 Feb;85(1):134-140. doi: 10.18999/nagjms.85.1.134.
    33. Aoki T, Yamada A, Kobayashi K, Yamauchi A, Omori J, Ikeya T, Aoyama T, Tominaga N, Sato Y, Kishino T, Ishii N, Sawada T, Murata M, Takao A, Mizukami K, Kinjo K, Fujimori S, Uotani T, Fujita M, Sato H, Suzuki S, Narasaka T, Hayasaka J, Funabiki T, Kinjo Y, Mizuki A, Fujishiro M, Kaise M, Nagata N; Collaborators.Development and validation of a novel model for predicting stigmata of recent hemorrhage in acute lower gastrointestinal bleeding: Multicenter nationwide studyDig Endosc. 2023 Sep;35(6):777-789. doi: 10.1111/den.14533. Epub 2023 Mar 28.
    34. Furukawa K, Furune S, Ishikawa E, Kawashima H.Endoscopic submucosal dissection using an ultrathin endoscope for esophageal squamous cell carcinoma with anastomotic stenosisRev Esp Enferm Dig. 2023 Jan 31;116. doi: 10.17235/reed.2023.9461/2023. Online ahead of print.
    35. Ishigami M, Honda T, Ishizu Y, Imai N, Ito T, Yamamoto K, Kawashima H.Significance of pretreatment alpha-fetoprotein in patients with compensated severe fibrosis after hepatitis C viral eradicationJ Hepatobiliary Pancreat Sci. 2023 Jun;30(6):834-842. doi: 10.1002/jhbp.1309. Epub 2023 Feb 22.
    36. Nakaoka K, Ohno E, Kawabe N, Kuzuya T, Funasaka K, Nakagawa Y, Nagasaka M, Ishikawa T, Watanabe A, Tochio T, Miyahara R, Shibata T, Kawashima H, Hashimoto S, Hirooka Y.Current Status of the Diagnosis of Early-Stage Pancreatic Ductal AdenocarcinomaDiagnostics (Basel). 2023 Jan 6;13(2):215. doi: 10.3390/diagnostics13020215.
    37. Murate K, Nakamura M, Yamamura T, Maeda K, Sawada T, Ishikawa E, Kida Y, Esaki M, Hamazaki M, Iida T, Mizutani Y, Yamao K, Ishikawa T, Furukawa K, Ohno E, Honda T, Ishigami M, Kinoshita F, Ando M, Kawashima H.CO(2) enterography in endoscopic retrograde cholangiography using double-balloon endoscopy: A randomized clinical trialJ Gastroenterol Hepatol. 2023 May;38(5):761-767. doi: 10.1111/jgh.16112. Epub 2023 Jan 27.
    38. Ikegami S, Nakamura M, Honda T, Yamamura T, Maeda K, Sawada T, Ishikawa E, Yamamoto K, Furune S, Ishikawa T, Furukawa K, Ohno E, Ishigami M, Kinoshita F, Kadota Y, Tochio T, Shimomura Y, Hirooka Y, Kawashima H.Efficacy of 1-kestose supplementation in patients with mild to moderate ulcerative colitis: A randomised, double-blind, placebo-controlled pilot studyAliment Pharmacol Ther. 2023 Jun;57(11):1249-1257. doi: 10.1111/apt.17387. Epub 2023 Jan 16.
    39. Hida E, Muroi K, Kakushima N, Furune S, Ishikawa E, Mizutani Y, Sawada T, Keiko M, Yamamura T, Ishikawa T, Furukawa K, Ohno E, Nakamura M, Nishida K, Fujishiro M, Kawashima H.Diagnostic Performance of Endocytoscopy for Esophageal EosinophiliaDigestion. 2023;104(3):202-211. doi: 10.1159/000528174. Epub 2023 Jan 5.
    40. Yokoyama S, Ishizu Y, Honda T, Imai N, Ito T, Yamamoto K, Shirota C, Tainaka T, Sumida W, Makita S, Takimoto A, Nakagawa Y, Takada S, Ishigami M, Uchida H, Kawashima H.The presence of high-risk varices after sclerotherapy in biliary atresiaPediatr Int. 2023 Jan;65(1):e15454. doi: 10.1111/ped.15454.
    41. Yokoyama S, Ishizu Y, Honda T, Imai N, Ito T, Yamamoto K, Hinoki A, Sumida W, Shirota C, Tainaka T, Makita S, Yokota K, Uchida H, Ishigami M.Endoscopic injection sclerotherapy with polidocanol for cardiac varices in children and adolescentsArch Pediatr. 2023 Feb;30(2):109-112. doi: 10.1016/j.arcped.2022.11.016. Epub 2022 Dec 9.
    42. Yamamoto T, Morooka H, Ito T, Ishigami M, Mizuno K, Yokoyama S, Yamamoto K, Imai N, Ishizu Y, Honda T, Yokota K, Hase T, Maeda O, Hashimoto N, Ando Y, Akiyama M, Kawashima H.Clustering using unsupervised machine learning to stratify the risk of immune-related liver injuryJ Gastroenterol Hepatol. 2023 Feb;38(2):251-258. doi: 10.1111/jgh.16038. Epub 2022 Nov 8.
    43. Muroi K, Kakushima N, Furukawa K, Furune S, Ito N, Hirose T, Hida E, Suzuki T, Suzuki T, Hirai K, Shibata H, Ishikawa E, Sawada T, Maeda K, Yamamura T, Ohno E, Nakamura M, Fujishiro M, Kawashima H.Novel endoscopic approaches using the endocytoscopy for the target biopsy in esophageal eosinophiliaEsophagus. 2023 Apr;20(2):325-332. doi: 10.1007/s10388-022-00963-0. Epub 2022 Oct 18.
    44. Ishiwatari H, Kawabata T, Kawashima H, Nakai Y, Miura S, Kato H, Shiomi H, Fujimori N, Ogura T, Inatomi O, Kubota K, Fujisawa T, Takenaka M, Mori H, Noguchi K, Fujii Y, Sugiura T, Ideno N, Nakafusa T, Masamune A, Isayama H, Sasahira N.Clinical Outcomes of Inside Stents and Conventional Plastic Stents as Bridge-to-Surgery Options for Malignant Hilar Biliary ObstructionDig Dis Sci. 2023 Apr;68(4):1139-1147. doi: 10.1007/s10620-022-07718-y. Epub 2022 Oct 15.
    45. Nakanishi K, Tanaka C, Kanda M, Shimizu D, Furukawa K, Fujiwara M, Kawashima H, Kodera Y.Preoperative indocyanine green fluorescence injection to accurately determine a proximal margin during robotic distal gastrectomyAsian J Endosc Surg. 2023 Jan;16(1):152-156. doi: 10.1111/ases.13121. Epub 2022 Aug 19.
    46. Ito N, Funasaka K, Fujiyoshi T, Nishida K, Furukawa K, Kakushima N, Furune S, Ohno E, Nakamura M, Horiguchi N, Shibata T, Miyahara R, Haruta JI, Hirooka Y, Fujishiro M, Kawashima H.Scoring system for predicting the prognosis of elderly gastric cancer patients after endoscopic submucosal dissectionDig Endosc. 2023 Jan;35(1):67-76. doi: 10.1111/den.14416. Epub 2022 Sep 1.
    47. Furukawa K, Koike M, Miyahara R, Kawashima H.Esophageal tuberculosisRev Esp Enferm Dig. 2023 Oct;115(10):576-577. doi: 10.17235/reed.2022.9108/2022.
    48. Ito T, Nguyen VH, Tanaka T, Park H, Yeh ML, Kawanaka M, Arai T, Atsukawa M, Yoon EL, Tsai PC, Toyoda H, Huang JF, Henry L, Jun DW, Yu ML, Ishigami M, Nguyen MH, Cheung RC.Poor Diagnostic Efficacy of Noninvasive Tests for Advanced Fibrosis in Obese or Younger Than 60 Diabetic NAFLD patientsClin Gastroenterol Hepatol. 2023 Apr;21(4):1013-1022.e6. doi: 10.1016/j.cgh.2022.05.015. Epub 2022 May 30.
    49. Kawamura T, Yamamura T, Nakamura M, Maeda K, Sawada T, Ishikawa E, Iida T, Mizutani Y, Ishikawa T, Kakushima N, Furukawa K, Ohno E, Honda T, Kawashima H, Ishigami M.Accuracy of Serum Leucine-Rich Alpha-2 Glycoprotein in Evaluating Endoscopic Disease Activity in Crohn's DiseaseInflamm Bowel Dis. 2023 Feb 1;29(2):245-253. doi: 10.1093/ibd/izac076.
    50. Zhao M, Ma L, Honda T, Kato A, Ohshiro T, Yokoyama S, Yamamoto K, Ito T, Imai N, Ishizu Y, Nakamura M, Kawashima H, Tsuji NM, Ishigami M, Fujishiro M.Astaxanthin Attenuates Nonalcoholic Steatohepatitis with Downregulation of Osteoprotegerin in Ovariectomized Mice Fed Choline-Deficient High-Fat DietDig Dis Sci. 2023 Jan;68(1):155-163. doi: 10.1007/s10620-022-07489-6. Epub 2022 Apr 10.
    51. Inukai Y, Yamamoto K, Honda T, Ito T, Imai N, Ishizu Y, Nakamura M, Kawashima H, Ishigami M.Differences in the Intestinal Microbiome Associated with Diarrhea during Lenvatinib Treatment for Hepatocellular CarcinomaDig Dis. 2023;41(1):138-147. doi: 10.1159/000524298. Epub 2022 Mar 28.
    52. Liu JK, Vutien P, Huang DQ, Ishigami M, Landis CS, Nguyen MH; REAL-B Liver Transplant Study Group.Renal Outcomes With Tenofovir Alafenamide in Liver Transplant RecipientsClin Gastroenterol Hepatol. 2023 Feb;21(2):538-540.e4. doi: 10.1016/j.cgh.2022.01.035. Epub 2022 Feb 3.
    53. Kawamura T, Hirose T, Kakushima N, Furukawa K, Furune S, Ishikawa E, Sawada T, Keiko M, Yamamura T, Ishikawa T, Ohno E, Nakamura M, Honda T, Ishigami M, Kawashima H, Fujishiro M.Factors Related to Delayed Adverse Events of Endoscopic Submucosal Dissection in the DuodenumDig Dis. 2023;41(1):80-88. doi: 10.1159/000522362. Epub 2022 Feb 2.
    54. A new criterion including the aspartate aminotransferase-to-platelet ratio index and liver and spleen stiffness to rule out varices needing treatment in children with biliary atresia: Modification of the Baveno VII criteria.Hepatol Res. 2023 Oct 16
    55. Ishikawa T, Yamao K, Mizutani Y, Iida T, Kawashima H.Cutting edge of endoscopic ultrasound-guided fine-needle aspiration for solid pancreatic lesions.J Med Ultrason (2001). 2023 Nov 1
    56. Kataoka K, Ishikawa T, Ohno E, Yamao K, Mizutani Y, Iida T, Kato K, Kinoshita F, Yamamura T, Furukawa K, Nakamura M, Kawashima H.Randomized trial comparing 15 vs 5 actuations per pass during endoscopic ultrasound-guided fine-needle biopsy for specimen acquisition of solid pancreatic lesions.J Gastroenterol Hepatol
    57. Nakaoka K, Ohno E, Kawabe N, Kuzuya T, Funasaka K, Nakagawa Y, Nagasaka M, Ishikawa T, Watanabe A, Tochio T, Miyahara R, Shibata T, Kawashima H, Hashimoto S, Hirooka Y.Current Status of the Diagnosis of Early-Stage Pancreatic Ductal Adenocarcinoma.Diagnostics (Basel). 2023
    58. Kudo M, Ueshima K, Saeki I, Ishikawa T, Inaba Y, Morimoto N, Aikata H, Tanabe N, Wada Y, Kondo Y, Tsuda M, Nakao K, Ito T, Hosaka T, Kawamura Y, Kuzuya T, Nojiri S, Ogawa C, Koga H, Hino K, Ikeda M, Moriguchi M, Hisai T, Yoshimura K, Furuse J, Arai Y.A Phase 2, Prospective, Multicenter, Single-Arm Trial of Transarterial Chemoembolization Therapy in Combination Strategy with Lenvatinib in Patients with Unresectable Intermediate-Stage Hepatocellular Carcinoma: TACTICS-L TrialLiver Cancer. 2023 Jun 5;13(1):99-112. doi: 10.1159/000531377. eCollection 2024 Feb.
    59. Ito T, Nguyen MH.Perspectives on the Underlying Etiology of HCC and Its Effects on Treatment OutcomesJ Hepatocell Carcinoma. 2023 Mar 10;10:413-428. doi: 10.2147/JHC.S347959. eCollection 2023.
    60. Le MH, Le DM, Baez TC, Wu Y, Ito T, Lee EY, Lee K, Stave CD, Henry L, Barnett SD, Cheung R, Nguyen MH.Global incidence of non-alcoholic fatty liver disease: A systematic review and meta-analysis of 63 studies and 1,201,807 personsJ Hepatol. 2023 Aug;79(2):287-295. doi: 10.1016/j.jhep.2023.03.040. Epub 2023 Apr 9.
    61. Mizuno F, Imai N, Yasuda K, Yokoyama S, Yamamoto K, Ito T, Ishizu Y, Honda T, Ishigami M, Kawashima H.Successful Treatment with Steroids in a Patient with Vanishing Bile Duct Syndrome and Acute Tubular NecrosisIntern Med. 2023 May 10. doi: 10.2169/internalmedicine.1826-23. Online ahead of print.
    62. Maeda K, Gwilt KB, Schmieder SS, Zachos NC, Lencer WI.Protocol for measuring transcytosis and recycling of IgG in intestinal epithelial Caco-2 cells and primary human intestinal organoidsSTAR Protoc. 2023;4(2):102335.
    63. Ito T, Nguyen MH.Bulevirtide and tenofovir combination therapy for hepatitis D virus infection: longer treatment and more diverse trial populations are neededLancet Infect Dis. 2023 Jan;23(1):14-16. doi: 10.1016/S1473-3099(22)00412-1. Epub 2022 Sep 13.
  • 2022年
    1. Wada H, Murate K, Nakamura M, Furukawa K, Kakushima N, Yamamura T, Maeda K, Sawada T, Ishikawa E, Ishikawa T, Ohno E, Honda T, Kawashima H, Nakayama G, Hattori N, Umeda S, Ishigami M.The effects of ustekinumab on small intestinal lesions and stenotic lesionsNagoya J Med Sci. 2022 Nov;84(4):825-838. doi: 10.18999/nagjms.84.4.825.
    2. Ozawa N, Sato K, Sugimura A, Maki S, Tanaka T, Yamamoto K, Ito T, Ishizu Y, Kuzuya T, Honda T, Ishigami M, Fujishiro M, Ishikawa T, Ando S.Effect of illness uncertainty on alanine transaminase levels and aspartate aminotransferase levels in patients with nonalcoholic fatty liver diseaseNagoya J Med Sci. 2022 Nov;84(4):857-864. doi: 10.18999/nagjms.84.4.857.
    3. Rodriguez Meza MR, Nakamura M, Yamamura T, Maeda K, Sawada T, Ishikawa E, Kakushima N, Furukawa K, Iida T, Mizutani Y, Ishikawa T, Ohno E, Honda T, Kawashima H, Ishigami M.Analysis of immunologic comorbidities in ulcerative colitis patients: a tool to prevent exacerbations in ulcerative colitis casesNagoya J Med Sci. 2022 Nov;84(4):733-745. doi: 10.18999/nagjms.84.4.733.
    4. Yokoyama S, Ishizu Y, Honda T, Imai N, Ito T, Yamamoto K, Shirota C, Tainaka T, Sumida W, Makita S, Takimoto A, Nakagawa Y, Takada S, Ishigami M, Uchida H, Kawashima H.The presence of high-risk varices after sclerotherapy in biliary atresiaPediatr Int. 2022 Dec 21:e15454. doi: 10.1111/ped.15454. Online ahead of print.
    5. Matsuda Y, Koyama T, Yoshida K, Koizumi S, Nakamura K, Ishigami M, Tsubota H, Sakaguchi G.Effects of Low-Dose Tolvaptan for Fluid Management After Cardiovascular SurgeryCirc Rep. 2022 Nov 11;4(12):563-570. doi: 10.1253/circrep.CR-22-0107. eCollection 2022 Dec 9.
    6. Fukuchi K, Nanai K, Yuita H, Maru C, Tsukada J, Ishigami M, Nagai Y, Nakano Y, Yoshimura C, Yoneda K, Amano M, Nakamura K, Oda Y, Nishigohri H, Yamamoto S, Ohnishi-Totoki Y, Inaki K, Komori H, Nakano R, Kanari Y, Nishida A, Matsui Y, Funo S, Takahashi S, Ohtsuka T, Agatsuma T.Novel Antibody Exerts Antitumor Effect through Downregulation of CD147 and Activation of Multiple Stress SignalsJ Oncol. 2022 Nov 4;2022:3552793. doi: 10.1155/2022/3552793. eCollection 2022.
    7. Yamada K, Ohno E, Ishikawa T, Mizutani Y, Iida T, Uetsuki K, Yashika J, Aoki T, Mori H, Kawashima H.[Leptomeningeal carcinomatosis from duodenal papillary carcinoma]Nihon Shokakibyo Gakkai Zasshi. 2022;119(11):1043-1047. doi: 10.11405/nisshoshi.119.1043.
    8. Ohashi A, Yamamura T, Nakamura M, Maeda K, Sawada T, Ishikawa E, Yamamoto K, Ishikawa T, Kakushima N, Furukawa K, Ohno E, Honda T, Kawashima H, Ishigami M, Fujishiro M.Network Analysis of Gut Microbiota Including Fusobacterium and Oral Origin Bacteria and Their Distribution on Tumor Surface, Normal Mucosa, and in Feces in Patients with Colorectal CancerDigestion. 2022;103(6):451-461. doi: 10.1159/000527170. Epub 2022 Nov 7.
    9. Muroi K, Kakushima N, Furukawa K, Furune S, Ito N, Hirose T, Hida E, Suzuki T, Suzuki T, Hirai K, Shibata H, Ishikawa E, Sawada T, Maeda K, Yamamura T, Ohno E, Nakamura M, Fujishiro M, Kawashima H.Novel endoscopic approaches using the endocytoscopy for the target biopsy in esophageal eosinophiliaEsophagus. 2022 Oct 18. doi: 10.1007/s10388-022-00963-0. Online ahead of print.
    10. Ishiwatari H, Kawabata T, Kawashima H, Nakai Y, Miura S, Kato H, Shiomi H, Fujimori N, Ogura T, Inatomi O, Kubota K, Fujisawa T, Takenaka M, Mori H, Noguchi K, Fujii Y, Sugiura T, Ideno N, Nakafusa T, Masamune A, Isayama H, Sasahira N.Clinical Outcomes of Inside Stents and Conventional Plastic Stents as Bridge-to-Surgery Options for Malignant Hilar Biliary ObstructionDig Dis Sci. 2022 Oct 15. doi: 10.1007/s10620-022-07718-y. Online ahead of print.
    11. Ohno E, Kawashima H, Ishikawa T, Mizutani Y, Iida T, Nishio R, Uetsuki K, Yashika J, Yamada K, Yoshikawa M, Gibo N, Aoki T, Kataoka K, Mori H, Takada Y, Aoi H, Takahashi H, Yamamura T, Furukawa K, Nakamura M, Shimoyama Y, Hirooka Y, Fujishiro M.The role of EUS elastography-guided fine needle biopsy in the histological diagnosis of solid pancreatic lesions: a prospective exploratory studySci Rep. 2022 Oct 5;12(1):16603. doi: 10.1038/s41598-022-21178-4.
    12. Yoshikawa M, Ishikawa T, Ohno E, Iida T, Furukawa K, Nakamura M, Honda T, Ishigami M, Kinoshita F, Kawashima H, Fujishiro M.Author Correction: Variability measurements provide additional value to shear wave elastography in the diagnosis of pancreatic cancerSci Rep. 2022 Sep 28;12(1):16190. doi: 10.1038/s41598-022-21219-y.
    13. Maeda O, Matsuoka A, Yanagawa M, Muroyama Y, Watanabe K, Liang Y, Ishikawa T, Ohno E, Kawashima H, Umegaki H, Kuzuya M, Ando Y.Selection of chemotherapy for older patients with pancreatic cancer based on geriatric assessmentJ Geriatr Oncol. 2022 Nov;13(8):1260-1263. doi: 10.1016/j.jgo.2022.09.005. Epub 2022 Sep 15.
    14. Ando T, Aizaki H, Sugiyama M, Date T, Hayashi K, Ishigami M, Katano Y, Goto H, Mizokami M, Muramatsu M, Kuroda M, Wakita T.Independent evolution of multi-dominant viral genome species observed in a hepatitis C virus carrierBiochem Biophys Rep. 2022 Aug 29;32:101327. doi: 10.1016/j.bbrep.2022.101327. eCollection 2022 Dec.
    15. Furukawa K, Koike M, Miyahara R, Kawashima H.Esophageal tuberculosisRev Esp Enferm Dig. 2022 Aug 31. doi: 10.17235/reed.2022.9108/2022. Online ahead of print.
    16. Ishizu Y, Ishigami M, Honda T, Imai N, Ito T, Yamamoto K, Yokoyama S, Ishikawa T, Kawashima H.Decreased appetite is associated with the presence of sarcopenia in patients with cirrhosisNutrition. 2022 Nov-Dec;103-104:111807. doi: 10.1016/j.nut.2022.111807. Epub 2022 Jul 22.
    17. Gibo N, Hamaguchi T, Miki Y, Yamamura T, Nakaguro M, Ito M, Nakamuara M, Kawashima H, Hirayama M, Hirooka Y, Wakabayashi K, Ohno K.Examination of Abnormal Alpha-synuclein Aggregates in the Enteric Neural Plexus in Patients with Ulcerative ColitisJ Gastrointestin Liver Dis. 2022 Sep 15;31(3):290-300. doi: 10.15403/jgld-4313.
    18. Ishizu Y, Ishigami M, Honda T, Imai N, Ito T, Yamamoto K, Yokoyama S, Ishikawa T, Fujishiro M.Factors associated with the progression of myosteatosis in patients with cirrhosisNutrition. 2022 Nov-Dec;103-104:111777. doi: 10.1016/j.nut.2022.111777. Epub 2022 Jun 17.
    19. Yamamoto T, Ito T, Mizuno K, Shinya Y, Yamamoto K, Imai N, Ishizu Y, Honda T, Kawashima H, Matsui T, Hase T, Hashimoto N, Ishigami M.A case of antiprogrammed death-ligand 1 antibody-induced multisystem immune-related adverse events with pancreatitis and steroid-resistant sclerosing cholangitisJ Dig Dis. 2022 Jul;23(7):404-409. doi: 10.1111/1751-2980.13122.
    20. Nakagami A, Yasue M, Nakagaki K, Nakamura M, Kawai N, Ichinohe N.Reduced childhood social attention in autism model marmosets predicts impaired social skills and inflexible behavior in adulthoodFront Psychiatry. 2022 Jul 25;13:885433. doi: 10.3389/fpsyt.2022.885433. eCollection 2022.
    21. Sugiyama Y, Ishizu Y, Ando Y, Yokoyama S, Yamamoto K, Ito T, Imai N, Nakamura M, Honda T, Kawashima H, Ishikawa T, Ishigami M.An improved method to assess skeletal muscle mass in patients with liver cirrhosis based on computed tomography imagesHepatol Res. 2022 Nov;52(11):937-946. doi: 10.1111/hepr.13820. Epub 2022 Aug 16.
    22. Kobayashi T, Iwama S, Yamagami A, Yasuda Y, Okuji T, Ito M, Zhou X, Ando M, Onoue T, Miyata T, Sugiyama M, Hagiwara D, Suga H, Banno R, Hase T, Morise M, Ito T, Kikumori T, Inoue M, Ando Y, Masuda N, Kawashima H, Hashimoto N, Arima H.Elevated TSH Level, TgAb, and Prior Use of Ramucirumab or TKIs as Risk Factors for Thyroid Dysfunction in PD-L1 BlockadeJ Clin Endocrinol Metab. 2022 Sep 28;107(10):e4115-e4123. doi: 10.1210/clinem/dgac467.
    23. Imai N, Ishigami M, Oie Y, Kumagai M, Inukai Y, Yokoyama S, Yamamoto K, Ito T, Ishizu Y, Honda T, Kawashima H.Effectiveness of Porous Glass Membrane Pumping Emulsification Device in Transarterial Chemoembolization for Solitary Hepatocellular CarcinomaAnticancer Res. 2022 Aug;42(8):3947-3951. doi: 10.21873/anticanres.15889.
    24. Kakushima N, Fujishiro M, Chan SM, Cortas GA, Dinis-Ribeiro M, Gonzalez R, Kodashima S, Lee SY, Linghu E, Mabe K, Pan W, Parra-Blanco A, Pioche M, Rollan A, Sumiyama K, Tanimoto M; World Endoscopy Organization Stomach and Duodenal Diseases Committee.Proposal of minimum elements for screening and diagnosis of gastric cancer by an international Delphi consensusDEN Open. 2022 Feb 24;2(1):e97. doi: 10.1002/deo2.97. eCollection 2022 Apr.
    25. Ishikawa T, Ohno E, Mizutani Y, Iida T, Kawashima H.Pancreatic acinar cell carcinoma with predominant extension into the main pancreatic duct: A case reportDEN Open. 2022 Feb 24;2(1):e96. doi: 10.1002/deo2.96. eCollection 2022 Apr.
    26. Nagoshi N, Yoshii T, Egawa S, Sakai K, Kusano K, Tsutsui S, Hirai T, Matsukura Y, Wada K, Katsumi K, Koda M, Kimura A, Furuya T, Maki S, Nishida N, Nagamoto Y, Oshima Y, Ando K, Nakashima H, Takahata M, Mori K, Nakajima H, Murata K, Miyagi M, Kaito T, Yamada K, Banno T, Kato S, Ohba T, Inami S, Fujibayashi S, Katoh H, Kanno H, Watanabe K, Taneichi H, Imagama S, Kawaguchi Y, Takeshita K, Nakamura M, Matsumoto M, Yamazaki M, Okawa A.Clinical Indicators of Surgical Outcomes After Laminoplasty for Patients With Cervical Ossification of the Posterior Longitudinal Ligament: A Prospective Multicenter StudySpine (Phila Pa 1976). 2022 Aug 1;47(15):1077-1083. doi: 10.1097/BRS.0000000000004359. Epub 2022 Jul 15.
    27. Mori H, Kawashima H, Ohno E, Ishikawa T, Yamao K, Mizutani Y, Iida T, Nakamura M, Ishigami M, Onoe S, Mizuno T, Ebata T, Fujishiro M.Comparison of an Inside Stent and a Fully Covered Self-Expandable Metallic Stent as Preoperative Biliary Drainage for Patients with Resectable Perihilar CholangiocarcinomaCan J Gastroenterol Hepatol. 2022 Jul 5;2022:3005210. doi: 10.1155/2022/3005210. eCollection 2022.
    28. Kita T, Ashizuka S, Takeda T, Matsumoto T, Ohmiya N, Nakase H, Motoya S, Ohi H, Mitsuyama K, Hisamatsu T, Kanmura S, Kato N, Ishihara S, Nakamura M, Moriyama T, Saruta M, Nozaki R, Yamamoto S, Inatsu H, Watanabe K, Kitamura K.Adrenomedullin for biologic-resistant Crohn's disease: A randomized, double-blind, placebo-controlled phase 2a clinical trialJ Gastroenterol Hepatol. 2022 Nov;37(11):2051-2059. doi: 10.1111/jgh.15945. Epub 2022 Jul 25.
    29. Hamazaki M, Sawada T, Yamamura T, Maeda K, Mizutani Y, Ishikawa E, Furune S, Yamamoto K, Ishikawa T, Kakushima N, Furukawa K, Ohno E, Honda T, Kawashima H, Ishigami M, Nakamura M, Fujishiro M.Fecal microbiota transplantation in the treatment of irritable bowel syndrome: a single-center prospective study in JapanBMC Gastroenterol. 2022 Jul 14;22(1):342. doi: 10.1186/s12876-022-02408-5.
    30. Majima S, Wakahara K, Iwano S, Kinoshita F, Nakamura M, Hashimoto N, Fujishiro M, Hasegawa Y.Airway involvement in inflammatory bowel disease: Inflammatory bowel disease patients have bronchial wall thickeningRespir Investig. 2022 Sep;60(5):713-719. doi: 10.1016/j.resinv.2022.06.003. Epub 2022 Jul 9.
    31. Hirai T, Yoshii T, Hashimoto J, Ushio S, Mori K, Maki S, Katsumi K, Nagoshi N, Takeuchi K, Furuya T, Watanabe K, Nishida N, Nishimura S, Watanabe K, Kaito T, Kato S, Nagashima K, Koda M, Nakashima H, Imagama S, Murata K, Matsuoka Y, Wada K, Kimura A, Ohba T, Katoh H, Watanabe M, Matsuyama Y, Ozawa H, Haro H, Takeshita K, Matsumoto M, Nakamura M, Egawa S, Matsukura Y, Inose H, Okawa A, Yamazaki M, Kawaguchi Y.Clinical Characteristics of Patients with Ossification of the Posterior Longitudinal Ligament and a High OP Index: A Multicenter Cross-Sectional Study (JOSL Study)J Clin Med. 2022 Jun 27;11(13):3694. doi: 10.3390/jcm11133694.
    32. Aoki T, Ohno E, Ishikawa T, Mizutani Y, Iida T, Yamao K, Yamamura T, Furukawa K, Nakamura M, Honda T, Ishigami M, Yatsuya H, Kawashima H.Endoscopic sphincterotomy and endoscopic biliary stenting do not affect the sensitivity of transpapillary forceps biopsy for the diagnosis of bile duct adenocarcinomaBMC Gastroenterol. 2022 Jul 5;22(1):329. doi: 10.1186/s12876-022-02402-x.
    33. Yasuhiko Y, Ishigami M, Machino S, Fujii T, Aoki M, Irie F, Kanda Y, Yoshida M.Comparison of the lower limit of benchmark dose confidence interval with no-observed-adverse-effect level by applying four different software for tumorigenicity testing of pesticides in JapanRegul Toxicol Pharmacol. 2022 Aug;133:105201. doi: 10.1016/j.yrtph.2022.105201. Epub 2022 Jun 9.
    34. Ito Y, Ishigami M, Terai G, Nakamura Y, Hashiba N, Nishi T, Nakazawa H, Hasunuma T, Asai K, Umetsu M, Ishii J, Kondo A.A streamlined strain engineering workflow with genome-wide screening detects enhanced protein secretion in Komagataella phaffiiCommun Biol. 2022 Jun 8;5(1):561. doi: 10.1038/s42003-022-03475-w.
    35. Ito Y, Ishigami M, Hashiba N, Nakamura Y, Terai G, Hasunuma T, Ishii J, Kondo A.Avoiding entry into intracellular protein degradation pathways by signal mutations increases protein secretion in Pichia pastorisMicrob Biotechnol. 2022 Sep;15(9):2364-2378. doi: 10.1111/1751-7915.14061. Epub 2022 Jun 3.
    36. Ito T, Nguyen VH, Tanaka T, Park H, Yeh ML, Kawanaka M, Arai T, Atsukawa M, Yoon EL, Tsai PC, Toyoda H, Huang JF, Henry L, Jun DW, Yu ML, Ishigami M, Nguyen MH, Cheung RC.Poor Diagnostic Efficacy of Noninvasive Tests for Advanced Fibrosis in Obese or Younger Than 60 Diabetic NAFLD patientsClin Gastroenterol Hepatol. 2022 May 30:S1542-3565(22)00525-0. doi: 10.1016/j.cgh.2022.05.015. Online ahead of print.
    37. Matsuda N, Hirose T, Kakushima N, Furukawa K, Furune S, Ishikawa E, Sawada T, Maeda K, Yamamura T, Ishikawa T, Ohno E, Nakamura M, Honda T, Ishigami M, Kawashima H, Fujishiro M.Comparison of Endoscopic Ultrasonography and Conventional Endoscopy for Prediction of Tumor Depth in Superficial Nonampullary Duodenal Epithelial TumorsDigestion. 2022;103(4):319-328. doi: 10.1159/000524841. Epub 2022 Jun 1.
    38. Yasui H, Takeno A, Hara H, Imamura H, Akamatsu H, Fujitani K, Nakane M, Kondoh CN, Yukisawa S, Nasu J, Miyata Y, Makiyama A, Ishida H, Yoshida N, Matsumura E, Ishigami M, Sugihara M, Ochiai A, Doi T.Prospective analysis of the expression status of FGFR2 and HER2 in colorectal and gastric cancer populations: DS-Screen StudyInt J Colorectal Dis. 2022 Jun;37(6):1393-1402. doi: 10.1007/s00384-022-04162-2. Epub 2022 May 19.
    39. Iida T, Mizutani Y, Esaki N, Ponik SM, Burkel BM, Weng L, Kuwata K, Masamune A, Ishihara S, Haga H, Kataoka K, Mii S, Shiraki Y, Ishikawa T, Ohno E, Kawashima H, Hirooka Y, Fujishiro M, Takahashi M, Enomoto A.Correction: Pharmacologic conversion of cancer-associated fibroblasts from a protumor phenotype to an antitumor phenotype improves the sensitivity of pancreatic cancer to chemotherapeuticsOncogene. 2022 Jun;41(23):3302. doi: 10.1038/s41388-022-02336-4.
    40. Yokoyama S, Ishizu Y, Honda T, Imai N, Ito T, Yamamoto K, Komada T, Hayashi M, Ishigami M.Pipeline Esophagogastric Varices Secondary to Extrahepatic Portal Vein Obstruction Treated Endoscopically with the Assistance of Transileocolic ObliterationIntern Med. 2022 Dec 1;61(23):3503-3511. doi: 10.2169/internalmedicine.9404-22. Epub 2022 Apr 30.
    41. Maeda K, Nakamura M, Yamamura T, Sawada T, Ishikawa E, Oishi A, Ikegami S, Kakushima N, Furukawa K, Iida T, Mizutani Y, Ishikawa T, Ohno E, Honda T, Ishigami M, Kawashima H.Gelsolin as a Potential Biomarker for Endoscopic Activity and Mucosal Healing in Ulcerative ColitisBiomedicines. 2022 Apr 9;10(4):872. doi: 10.3390/biomedicines10040872.
    42. Kida Y, Yamamura T, Maeda K, Sawada T, Ishikawa E, Mizutani Y, Kakushima N, Furukawa K, Ishikawa T, Ohno E, Kawashima H, Nakamura M, Ishigami M, Fujishiro M.Diagnostic performance of endoscopic classifications for neoplastic lesions in patients with ulcerative colitis: A retrospective case-control studyWorld J Gastroenterol. 2022 Mar 14;28(10):1055-1066. doi: 10.3748/wjg.v28.i10.1055.
    43. Iida T, Mizutani Y, Esaki N, Ponik SM, Burkel BM, Weng L, Kuwata K, Masamune A, Ishihara S, Haga H, Kataoka K, Mii S, Shiraki Y, Ishikawa T, Ohno E, Kawashima H, Hirooka Y, Fujishiro M, Takahashi M, Enomoto A.Pharmacologic conversion of cancer-associated fibroblasts from a protumor phenotype to an antitumor phenotype improves the sensitivity of pancreatic cancer to chemotherapeuticsOncogene. 2022 May;41(19):2764-2777. doi: 10.1038/s41388-022-02288-9. Epub 2022 Apr 13.
    44. Ohno E, Ishikawa T, Mizutani Y, Iida T, Uetsuki K, Yashika J, Yamada K, Gibo N, Aoki T, Kawashima H.Factors associated with misdiagnosis of preoperative endoscopic ultrasound in patients with pancreatic cystic neoplasms undergoing surgical resectionJ Med Ultrason (2001). 2022 Jul;49(3):433-441. doi: 10.1007/s10396-022-01205-7. Epub 2022 Apr 12.
    45. Ito N, Funasaka K, Fujiyoshi T, Furukawa K, Kakushima N, Furune S, Ishikawa E, Mizutani Y, Sawada T, Maeda K, Ishikawa T, Yamamura T, Ohno E, Nakamura M, Kawashima H, Miyahara R, Hirooka Y, Haruta JI, Fujishiro M.Modified N score is helpful for identifying patients who need endoscopic intervention among those with black stools without hematemesisDig Endosc. 2022 Sep;34(6):1157-1165. doi: 10.1111/den.14323. Epub 2022 May 24.
    46. Nakamura M, Yamamura T, Maeda K, Sawada T, Mizutani Y, Ishikawa E, Ishikawa T, Kakushima N, Furukawa K, Ohno E, Kawashima H, Honda T, Ishigami M, Fujishiro M.Initial experience of tofacitinib for treating refractory moderate-to-severe ulcerative colitisNagoya J Med Sci. 2022 Feb;84(1):169-179. doi: 10.18999/nagjms.84.1.169.
    47. Kawashima H, Ohno E, Ishikawa T, Mizutani Y, Iida T, Yamamura T, Kakushima N, Furukawa K, Nakamura M.Endoscopic management of perihilar cholangiocarcinomaDig Endosc. 2022 Sep;34(6):1147-1156. doi: 10.1111/den.14317. Epub 2022 Jun 2.
    48. Kawaratani H, Kondo Y, Tatsumi R, Kawabe N, Tanabe N, Sakamaki A, Okumoto K, Uchida Y, Endo K, Kawaguchi T, Oikawa T, Ishizu Y, Hige S, Takami T, Terai S, Ueno Y, Mochida S, Takikawa Y, Torimura T, Matsuura T, Ishigami M, Koike K, Yoshiji H.Long-Term Efficacy and Safety of Rifaximin in Japanese Patients with Hepatic Encephalopathy: A Multicenter Retrospective StudyJ Clin Med. 2022 Mar 12;11(6):1571. doi: 10.3390/jcm11061571.
    49. Isayama H, Tazuma S, Kokudo N, Tanaka A, Tsuyuguchi T, Nakazawa T, Notohara K, Mizuno S, Akamatsu N, Serikawa M, Naitoh I, Hirooka Y, Wakai T, Itoi T, Ebata T, Okaniwa S, Kamisawa T, Kawashima H, Kanno A, Kubota K, Tabata M, Unno M, Takikawa H; PSC guideline committee Members: Ministry of Health, Labour and Welfare (Japan) Research Project, The Intractable Hepatobiliary Disease Study Group.Correction to: Clinical guidelines for primary sclerosing cholangitis 2017J Gastroenterol. 2022 Jun;57(6):453-454. doi: 10.1007/s00535-022-01867-7.
    50. Makita S, Amano H, Kawashima H, Hinoki A, Shirota C, Tainaka T, Sumida W, Yokota K, Okamoto M, Takimoto A, Yasui A, Nakagawa Y, Uchida H.Utility of endoscopic retrograde cholangiopancreatography in management of pediatric pancreaticobiliary diseaseBMC Pediatr. 2022 Mar 14;22(1):134. doi: 10.1186/s12887-022-03207-3.
    51. Yamamoto T, Imai N, Kuzuya T, Yokoyama S, Yamamoto K, Ito T, Ishizu Y, Honda T, Ishigami M.Changes in Body Composition Predict the Time to Treatment Failure of Lenvatinib in Patients with Advanced Hepatocellular Carcinoma: A Pilot Retrospective StudyNutr Cancer. 2022;74(9):3118-3127. doi: 10.1080/01635581.2022.2049322. Epub 2022 Mar 12.
    52. Yamaguchi J, Yokoyama Y, Fujii T, Yamada S, Takami H, Kawashima H, Ohno E, Ishikawa T, Maeda O, Ogawa H, Kodera Y, Nagino M, Ebata T.Results of a Phase II Study on the Use of Neoadjuvant Chemotherapy (FOLFIRINOX or GEM/nab-PTX) for Borderline-resectable Pancreatic Cancer (NUPAT-01)Ann Surg. 2022 Jun 1;275(6):1043-1049. doi: 10.1097/SLA.0000000000005430. Epub 2022 Mar 3.
    53. Yamamoto K, Ishizu Y, Honda T, Ito T, Imai N, Nakamura M, Kawashima H, Kitaura Y, Ishigami M, Fujishiro M.Patients with low muscle mass have characteristic microbiome with low potential for amino acid synthesis in chronic liver diseaseSci Rep. 2022 Mar 7;12(1):3674. doi: 10.1038/s41598-022-07810-3.
    54. Mizutani Y, Iida T, Ohno E, Ishikawa T, Kinoshita F, Kuwatsuka Y, Imai M, Shimizu S, Tsuruta T, Enomoto A, Kawashima H, Fujishiro M.Safety and efficacy of MIKE-1 in patients with advanced pancreatic cancer: a study protocol for an open-label phase I/II investigator-initiated clinical trial based on a drug repositioning approach that reprograms the tumour stromaBMC Cancer. 2022 Feb 24;22(1):205. doi: 10.1186/s12885-022-09272-2.
    55. Ishikawa T, Hayakawa M, Suzuki H, Ohno E, Mizutani Y, Iida T, Fujishiro M, Kawashima H, Hotta K.Development of a Novel Evaluation Method for Endoscopic Ultrasound-Guided Fine-Needle Biopsy in Pancreatic Diseases Using Artificial IntelligenceDiagnostics (Basel). 2022 Feb 8;12(2):434. doi: 10.3390/diagnostics12020434.
    56. Kataoka K, Ishikawa T, Ohno E, Mizutani Y, Iida T, Furukawa K, Nakamura M, Honda T, Ishigami M, Kawashima H, Hirooka Y, Fujishiro M.Differentiation Between Solid Pseudopapillary Neoplasm of the Pancreas and Nonfunctional Pancreatic Neuroendocrine Neoplasm Using Endoscopic UltrasoundPancreas. 2022 Jan 1;51(1):106-111. doi: 10.1097/MPA.0000000000001966.
    57. Muroi K, Kakushima N, Furukawa K, Furune S, Ito N, Hirose T, Ishikawa E, Mizutani Y, Sawada T, Maeda K, Yamamura T, Ishikawa T, Ohno E, Nakamura M, Kawashima H, Funasaka K, Miyahara R, Fujishiro M.Effects of steroid use for stenosis prevention after endoscopic submucosal dissection for cervical esophageal cancerInt J Clin Oncol. 2022 May;27(5):940-947. doi: 10.1007/s10147-022-02139-3. Epub 2022 Feb 22.
    58. Yoshida K, Nakamura K, Ishigami M, Kinoshita M, Koyama T.Staged graft replacement with thoracic endovascular aneurysm repair for an extensive thoracoabdominal aortic aneurysm after total arch replacementJ Cardiothorac Surg. 2022 Feb 21;17(1):20. doi: 10.1186/s13019-022-01764-3.
    59. Nakamura M, Maeda K, Yamamoto K, Yamamura T, Sawada T, Ishikawa E, Kakushima N, Furukawa K, Iida T, Mizutani Y, Ishikawa T, Ohno E, Honda T, Ishigami M, Kawashima H.Preliminary Comparison of Endoscopic Brush and Net Catheters as the Sampling Tool to Analyze the Intestinal Mucus in the Rectum with Ulcerative Colitis PatientsDigestion. 2022;103(3):232-243. doi: 10.1159/000521929. Epub 2022 Feb 18.
    60. Hirose T, Kakushima N, Fujishiro M.[Endoscopic managements for superficial non-ampullary duodenal tumors]Nihon Shokakibyo Gakkai Zasshi. 2022;119(2):118-125. doi: 10.11405/nisshoshi.119.118.
    61. Meza MRR, Nakamura M, Yamamura T, Maeda K, Sawada T, Ishikawa E, Kakushima N, Furukawa K, Ohno E, Honda T, Kawashima H, Ishigami M.Immunoproliferative Small Intestinal Disease Diagnosed by Double-balloon Endoscopy with Biopsy SamplingIntern Med. 2022 Sep 1;61(17):2593-2599. doi: 10.2169/internalmedicine.8847-21. Epub 2022 Feb 8.
    62. Takada Y, Kawashima H, Ohno E, Ishikawa T, Mizutani Y, Iida T, Yamamura T, Kakushima N, Furukawa K, Nakamura M, Honda T, Ishigami M, Ito A, Hirooka Y.The impact of the age-adjusted Charlson comorbidity index as a prognostic factor for endoscopic papillectomy in ampullary tumorsJ Gastroenterol. 2022 Mar;57(3):199-207. doi: 10.1007/s00535-022-01853-z. Epub 2022 Jan 30.
    63. Ishikawa T, Ohno E, Mizutani Y, Iida T, Uetsuki K, Yashika J, Yamada K, Gibo N, Aoki T, Kataoka K, Mori H, Takada Y, Takahashi H, Aoi H, Kato K, Yamamura T, Kakushima N, Furukawa K, Nakamura M, Hirooka Y, Kawashima H.Usefulness of Macroscopic On-Site Evaluation Using a Stereomicroscope during EUS-FNB for Diagnosing Solid Pancreatic LesionsCan J Gastroenterol Hepatol. 2022 Jan 18;2022:2737578. doi: 10.1155/2022/2737578. eCollection 2022.
    64. Ishikawa E, Nakamura M, Satou A, Shimada K, Nakamura S.Mucosa-Associated Lymphoid Tissue (MALT) Lymphoma in the Gastrointestinal Tract in the Modern EraCancers (Basel). 2022 Jan 17;14(2):446. doi: 10.3390/cancers14020446.
    65. Kataoka K, Kawashima H, Ohno E, Ishikawa T, Mizutani Y, Iida T, Furukawa K, Nakamura M, Honda T, Ishigami M, Fujishiro M.Comparison of outcomes between secondary fully covered and uncovered self-expandable metal stents in the treatment of recurrent biliary obstruction of pancreatic cancerSurg Endosc. 2022 Aug;36(8):5676-5683. doi: 10.1007/s00464-021-08981-2. Epub 2022 Jan 12.
    66. Ito N, Funasaka K, Miyahara R, Furukawa K, Yamamura T, Ishikawa T, Ohno E, Nakamura M, Kawashima H, Hirooka Y, Fujishiro M.Relationship between psoas muscle index and long-term survival in older patients aged ? 80 years after endoscopic submucosal dissection for gastric cancerInt J Clin Oncol. 2022 Apr;27(4):729-738. doi: 10.1007/s10147-021-02112-6. Epub 2022 Jan 11.
    67. Yamada K, Ishikawa T, Kawashima H, Ohno E, Iida T, Ishikawa E, Mizutani Y, Sawada T, Maeda K, Yamamura T, Kakushima N, Furukawa K, Nakamura M, Ishigami M, Fujishiro M.Evaluation of ulcerative colitis activity using transabdominal ultrasound shear wave elastographyQuant Imaging Med Surg. 2022 Jan;12(1):618-626. doi: 10.21037/qims-21-403.
    68. Takada Y, Ishikawa T, Kawashima H, Mizutani Y, Ohno E, Iida T, Ogawa H, Hayashi M, Takami H, Onoe S, Ishigami M.Fish bone migration after pancreaticoduodenectomy: Incidence and treatment optionsJ Dig Dis. 2022 Jan;23(1):44-49. doi: 10.1111/1751-2980.13077. Epub 2022 Jan 18.
    69. Nakaoka K, Hashimoto S, Miyahara R, Kawashima H, Ohno E, Ishikawa T, Kuwahara T, Tanaka H, Hirooka Y.Current status of the diagnosis of chronic pancreatitis by ultrasonographic elastographyKorean J Intern Med. 2022 Jan;37(1):27-36. doi: 10.3904/kjim.2021.252. Epub 2021 Dec 15.
    70. Ishikawa T, Ohno E, Mizutani Y, Iida T, Koya T, Sasaki Y, Ogawa H, Kinoshita F, Hirooka Y, Kawashima H.Comparison of contrast-enhanced transabdominal ultrasonography following endoscopic ultrasonography with GD-EOB-DTPA-enhanced MRI for the sequential diagnosis of liver metastasis in patients with pancreatic cancerJ Hepatobiliary Pancreat Sci. 2022 Jun;29(6):682-692. doi: 10.1002/jhbp.1097. Epub 2021 Dec 21.
    71. Asai H, Furukawa K, Miyahara R, Funasaka K, Furune S, Nakamura M, Kawashima H, Ishigami M, Hirooka Y, Fujishiro M.Feasibility of endoscopic ultrasonography using a 60-MHz ultrasound miniature probe in the upper gastrointestinal tractJ Med Ultrason (2001). 2022 Jan;49(1):61-69. doi: 10.1007/s10396-021-01172-5. Epub 2021 Nov 26.
    72. Furune S, Yamamoto K, Honda T, Fujiyoshi T, Kakushima N, Furukawa K, Ohno E, Nakamura M, Miyahara R, Kawashima H, Ishigami M, Hirooka Y, Fujishiro M.Changes in the gut microbiome in relation to the degree of gastric mucosal atrophy before and after Helicobacter pylori eradicationScand J Gastroenterol. 2022 Mar;57(3):266-273. doi: 10.1080/00365521.2021.2005135. Epub 2021 Nov 24.
    73. Iwama S, Kobayashi T, Yasuda Y, Okuji T, Ito M, Ando M, Zhou X, Yamagami A, Onoue T, Kawaguchi Y, Miyata T, Sugiyama M, Takagi H, Hagiwara D, Suga H, Banno R, Hase T, Morise M, Wakahara K, Yokota K, Kato M, Nishio N, Tanaka C, Miyata K, Ogura A, Ito T, Sawada T, Shimokata T, Niimi K, Ohka F, Ishigami M, Gotoh M, Hashimoto N, Saito R, Kiyoi H, Kajiyama H, Ando Y, Hibi H, Sone M, Akiyama M, Kodera Y, Arima H.Increased Risk of Thyroid Dysfunction by PD-1 and CTLA-4 Blockade in Patients Without Thyroid Autoantibodies at BaselineJ Clin Endocrinol Metab. 2022 Mar 24;107(4):e1620-e1630. doi: 10.1210/clinem/dgab829.
    74. Hirai K, Kuwahara T, Furukawa K, Kakushima N, Furune S, Yamamoto H, Marukawa T, Asai H, Matsui K, Sasaki Y, Sakai D, Yamada K, Nishikawa T, Hayashi D, Obayashi T, Komiyama T, Ishikawa E, Sawada T, Maeda K, Yamamura T, Ishikawa T, Ohno E, Nakamura M, Kawashima H, Ishigami M, Fujishiro M.Artificial intelligence-based diagnosis of upper gastrointestinal subepithelial lesions on endoscopic ultrasonography imagesGastric Cancer. 2022 Mar;25(2):382-391. doi: 10.1007/s10120-021-01261-x. Epub 2021 Nov 16.
    75. Yokoyama S, Ishizu Y, Honda T, Imai N, Ito T, Yamamoto K, Tsuzuki T, Ishigami M.Absence of large portal collateral vessels is associated with spontaneous improvement of cirrhotic portal vein thrombosisHepatol Res. 2022 Feb;52(2):199-209. doi: 10.1111/hepr.13725. Epub 2021 Nov 3.
    76. Yamamoto T, Ito T, Hase T, Ishigami M, Mizuno K, Yamamoto K, Imai N, Ishizu Y, Honda T, Shibata H, Hatta T, Yogo N, Yasuda S, Toyoda H, Abe T, Kawashima H, Hashimoto N, Fujishiro M.Immune-related Liver Injury is a Poor Prognostic Factor in Patients with Nonsmall Cell Lung Cancer Treated with Immune Checkpoint InhibitorsCancer Invest. 2022 Feb;40(2):189-198. doi: 10.1080/07357907.2021.1994586. Epub 2021 Nov 29.
    77. Inukai Y, Imai N, Yamamoto K, Ito T, Ishizu Y, Honda T, Okamoto S, Kanematsu T, Suzuki N, Matsushita T, Ishigami M, Fujishiro M.The influence of hepatitis C virus eradication on hepatocarcinogenesis in patients with hemophiliaAnn Hepatol. 2022 Jan-Feb;27(1):100545. doi: 10.1016/j.aohep.2021.100545. Epub 2021 Sep 24.
    78. Toyoshima O, Nishizawa T, Yoshida S, Matsuno T, Odawara N, Toyoshima A, Sakitani K, Watanabe H, Fujishiro M, Suzuki H.Consistency between the endoscopic Kyoto classification and pathological updated Sydney system for gastritis: A cross-sectional studyJ Gastroenterol Hepatol. 2022 Feb;37(2):291-300. doi: 10.1111/jgh.15693. Epub 2021 Oct 6.
    79. Nagami Y, Hatta W, Tsuji Y, Yoshio T, Kakushima N, Hoteya S, Tsuji S, Fukunaga S, Hikichi T, Kobayashi M, Morita Y, Sumiyoshi T, Iguchi M, Tomida H, Inoue T, Mikami T, Hasatani K, Nishikawa J, Matsumura T, Nebiki H, Nakamatsu D, Ohnita K, Suzuki H, Ueyama H, Hayashi Y, Yoshida H, Fujishiro M, Masamune A, Fujiwara Y.Antithrombotics increase bleeding after endoscopic submucosal dissection for gastric cancer: Nationwide propensity score analysisDig Endosc. 2022 Jul;34(5):974-983. doi: 10.1111/den.14151. Epub 2021 Oct 19.
    80. Yabuuchi Y, Hatta W, Tsuji Y, Yoshio T, Kakushima N, Hoteya S, Doyama H, Nagami Y, Hikichi T, Kobayashi M, Morita Y, Sumiyoshi T, Iguchi M, Tomida H, Inoue T, Mikami T, Hasatani K, Nishikawa J, Matsumura T, Nebiki H, Nakamatsu D, Ohnita K, Suzuki H, Ueyama H, Hayashi Y, Sugimoto M, Yamaguchi S, Michida T, Yada T, Asahina Y, Narasaka T, Kuribayashi S, Kiyotoki S, Mabe K, Fujishiro M, Masamune A, Ono H.Influence of hospital volume on bleeding after endoscopic submucosal dissection for early gastric cancer in Japan: a multicenter propensity score-matched analysisSurg Endosc. 2022 Jun;36(6):4004-4013. doi: 10.1007/s00464-021-08721-6. Epub 2021 Sep 7.
    81. Furukawa K, Nakamura M, Kawashima H, Fujishiro M.Endoscopic resection of a duodenal neuroendocrine tumorRev Esp Enferm Dig. 2022 May;114(5):291-292. doi: 10.17235/reed.2021.8232/2021.
    82. Furukawa K, Yamamura T, Nakamura M, Kawashima H, Fujishiro M.Gastrointestinal: Idiopathic omental hemorrhageJ Gastroenterol Hepatol. 2022 Feb;37(2):282. doi: 10.1111/jgh.15639. Epub 2021 Aug 13.
    83. Hirose T, Kakushima N, Fujishiro M.Sudden Chest Pain During Vomiting After DrinkingGastroenterology. 2022 Apr;162(4):e5-e6. doi: 10.1053/j.gastro.2021.07.048. Epub 2021 Aug 9.
    84. Ohmiya N, Oka S, Nakayama Y, Iwama I, Nakamura M, Shimizu H, Sumioka A, Abe N, Kudo T, Osawa S, Honma H, Okuhira T, Mtsufuji S, Imaeda H, Ota K, Matsuoka R, Hotta N, Inoue M, Nakaji K, Takamaru H, Ozeki K, Kobayashi T, Hosoe N, Tajiri H, Tanaka S.Safety and efficacy of the endoscopic delivery of capsule endoscopes in adult and pediatric patients: Multicenter Japanese study (AdvanCE-J study)Dig Endosc. 2022 Mar;34(3):543-552. doi: 10.1111/den.14104. Epub 2021 Sep 10.
    85. Ito N, Funasaka K, Furukawa K, Kakushima N, Hirose T, Muroi K, Suzuki T, Suzuki T, Hida E, Ishikawa T, Yamamura T, Ohno E, Nakamura M, Kawashima H, Miyahara R, Fujishiro M.A novel scoring system to predict therapeutic intervention for non-variceal upper gastrointestinal bleedingIntern Emerg Med. 2022 Mar;17(2):423-430. doi: 10.1007/s11739-021-02822-9. Epub 2021 Aug 7.
    86. Koizumi S, Ishigami M, Tsubota H, Koyama T.Short- and mid-term outcomes of the frozen elephant-trunk procedure for degenerative aortic arch aneurysmSurg Today. 2022 Feb;52(2):324-329. doi: 10.1007/s00595-021-02337-y. Epub 2021 Jul 19.
    87. Takada Y, Hirose T, Nishida K, Kakushima N, Furukawa K, Furune S, Ishikawa E, Sawada T, Maeda K, Yamamura T, Ishikawa T, Ohno E, Nakamura M, Honda T, Ishigami M, Kawashima H, Fujishiro M.Fecal incontinence and oral regurgitation during duodenal endoscopic submucosal dissection using the water pressure methodDig Endosc. 2022 Mar;34(3):526-534. doi: 10.1111/den.14070. Epub 2021 Jul 16.
    88. Kawano T, Souzaki R, Sumida W, Ishimaru T, Fujishiro J, Hishiki T, Kinoshita Y, Kawashima H, Uchida H, Tajiri T, Yoneda A, Oue T, Kuroda T, Koshinaga T, Hiyama E, Nio M, Inomata Y, Taguchi T, Ieiri S.Laparoscopic approach for abdominal neuroblastoma in Japan: results from nationwide multicenter surveySurg Endosc. 2022 May;36(5):3028-3038. doi: 10.1007/s00464-021-08599-4. Epub 2021 Jun 18.
    89. Nakamura M, Kawashima H, Ishigami M, Fujishiro M.Indications and Limitations Associated with the Patency Capsule Prior to Capsule EndoscopyIntern Med. 2022 Jan 1;61(1):5-13. doi: 10.2169/internalmedicine.6823-20. Epub 2021 Jun 12.
    90. Mori K, Yoshii T, Hirai T, Maki S, Katsumi K, Nagoshi N, Nishimura S, Takeuchi K, Ushio S, Furuya T, Watanabe K, Nishida N, Watanabe K, Kaito T, Kato S, Nagashima K, Koda M, Ito K, Imagama S, Matsuoka Y, Wada K, Kimura A, Ohba T, Katoh H, Matsuyama Y, Ozawa H, Haro H, Takeshita K, Watanabe M, Matsumoto M, Nakamura M, Yamazaki M, Okawa A, Kawaguchi Y.The characteristics of the young patients with cervical ossification of the posterior longitudinal ligament of the spine: A multicenter cross-sectional studyJ Orthop Sci. 2022 Jul;27(4):760-766. doi: 10.1016/j.jos.2021.04.010. Epub 2021 Jun 4.
    91. Yabuuchi Y, Yoshida M, Kakushima N, Kato M, Iguchi M, Yamamoto Y, Kanetaka K, Uraoka T, Fujishiro M, Sho M; Japan Duodenal Cancer Committee.Risk Factors for Non-Ampullary Duodenal Adenocarcinoma: A Systematic ReviewDig Dis. 2022;40(2):147-155. doi: 10.1159/000516561. Epub 2021 Apr 22.
    92. Reveron-Thornton RF, Teng MLP, Lee EY, Tran A, Vajanaphanich S, Tan EX, Nerurkar SN, Ng RX, Teh R, Tripathy DP, Ito T, Tanaka T, Miyake N, Zou B, Wong C, Toyoda H, Esquivel CO, Bonham CA, Nguyen MH, Huang DQ.Global and regional long-term survival following resection for HCC in the recent decade: A meta-analysis of 110 studiesHepatol Commun. 2022 Jul;6(7):1813-1826. doi: 10.1002/hep4.1923. Epub 2022 Mar 2.
    93. Ye Q, Ito T, Henry L, Nguyen MH.Metabolic abnormalities play a crucial role in non-obese people suffering from non-alcoholic fatty liver disease (NAFLD)Hepatobiliary Surg Nutr. 2022 Apr;11(2):333-334. doi: 10.21037/hbsn-22-26.
    94. Kumada T, Toyoda H, Yasuda S, Ogawa S, Gotoh T, Ito T, Tada T, Tanaka J.Liver Stiffness Measurements by 2D Shear-Wave Elastography: Effect of Steatosis on Fibrosis EvaluationAJR Am J Roentgenol. 2022 Oct;219(4):604-612. doi: 10.2214/AJR.22.27656. Epub 2022 May 4.
    95. Kumada T, Ogawa S, Goto T, Toyoda H, Yasuda S, Ito T, Yasuda E, Akita T, Tanaka J.Intra-individual Comparisons of the Ultrasound-Guided Attenuation Parameter and the Magnetic Resonance Imaging-Based Proton Density Fat Fraction Using Bias and Precision StatisticsUltrasound Med Biol. 2022 Aug;48(8):1537-1546. doi: 10.1016/j.ultrasmedbio.2022.03.019. Epub 2022 May 22.
    96. Kumada T, Toyoda H, Yasuda S, Ogawa S, Gotoh T, Tada T, Ito T, Sumida Y, Tanaka J.Combined ultrasound and magnetic resonance elastography predict hepatocellular carcinoma after hepatitis C virus eradicationHepatol Res. 2022 Nov;52(11):957-967. doi: 10.1111/hepr.13814. Epub 2022 Aug 12.
    97. Kumada T, Toyoda H, Yasuda S, Ito T, Tsuji K, Fujioka S, Hiraoka A, Kariyama K, Nouso K, Ishikawa T, Tamai T, Tada T, Tanaka J.Factors linked to hepatocellular carcinoma development beyond 10 years after viral eradication in patients with hepatitis C virusJ Viral Hepat. 2022 Oct;29(10):919-929. doi: 10.1111/jvh.13728. Epub 2022 Jul 9.
    98. Dao AD, Nguyen VH, Ito T, Cheung R, Nguyen MH.Prevalence, characteristics, and mortality outcomes of obese and nonobese MAFLD in the United StatesHepatol Int. 2022 Oct 29. doi: 10.1007/s12072-022-10436-2. Online ahead of print.
    99. Sumida W, Tainaka T, Shirota C, Yokota K, Makita S, Okamoto M, Takimoto A, Yasui A, Takada S, Nakagawa Y, Kato D, Yokoyama S, Ishizu Y, Amano H, Guo Y, Hinoki A, Uchida H.Biochemical markers to predict the development of gastrointestinal bleeding and esophageal varices after portoenterostomy in biliary atresiaPediatr Surg Int . 2022 Dec;38(12):1799-1805. doi: 10.1007/s00383-022-05243-7. Epub 2022 Sep 17.
    100. Kumada T, Toyoda H, Yasuda S, Ito T, Tanaka J.Mortality of inactive hepatitis B virus carriers in Japan is similar to that of the general populationHepatol Res. 2022 Jan;52(1):81-92. doi: 10.1111/hepr.13723. Epub 2021 Nov 3.
    101. Matsumoto K, Ohfuji S, Abe M, Komori A, Takahashi A, Fujii H, Kawata K, Noritake H, Tadokoro T, Honda A, Asami M, Namisaki T, Ueno M, Sato K, Kakisaka K, Arakawa M, Ito T, Tanaka K, Matsui T, Setsu T, Takamura M, Yasuda S, Katsumi T, Itakura J, Sano T, Tamura Y, Miura R, Arizumi T, Asaoka Y, Uno K, Nishitani A, Ueno Y, Terai S, Takikawa Y, Morimoto Y, Yoshiji H, Mochida S, Ikegami T, Masaki T, Kawada N, Ohira H, Tanaka A.Environmental factors, medical and family history, and comorbidities associated with primary biliary cholangitis in Japan: a multicenter case-control studyJ Gastroenterol. 2022 Jan;57(1):19-29. doi: 10.1007/s00535-021-01836-6. Epub 2021 Nov 18.
    102. Maeda K, Zachos NC, Orzalli MH, Schmieder SS, Chang D, Bugda Gwilt K, Doucet M, Baetz NW, Lee S, Crawford SE, Estes MK, Kagan JC, Turner JR, Lencer WI.Epithelial cell-autonomous host defense at mucosal surfaces by rapid degradation of PARD6B to deplete the apical endosomeCell Host& Microbe 2022 ;30 (2):216-231.
  • 2021年
    1. Hatta W, Tsuji Y, Yoshio T, Kakushima N, Hoteya S, Doyama H, Nagami Y, Hikichi T, Kobayashi M, Morita Y, Sumiyoshi T, Iguchi M, Tomida H, Inoue T, Koike T, Mikami T, Hasatani K, Nishikawa J, Matsumura T, Nebiki H, Nakamatsu D, Ohnita K, Suzuki H, Ueyama H, Hayashi Y, Sugimoto M, Yamaguchi S, Michida T, Yada T, Asahina Y, Narasaka T, Kuribasyashi S, Kiyotoki S, Mabe K, Nakamura T, Nakaya N, Fujishiro M, Masamune A.Prediction model of bleeding after endoscopic submucosal dissection for early gastric cancer: BEST-J scoreGut. 2021 Mar;70(3):476-484. doi: 10.1136/gutjnl-2019-319926. Epub 2020 Jun 4.
    2. Nakamura M, Yamamura T, Maeda K, Sawada T, Mizutani Y, Ishikawa E, Kakushima N, Furukawa K, Ishikawa T, Ohno E, Honda T, Kawashima H, Ishigami M, Fujishiro M.Clinical Features of Ischemic Enteritis Diagnosed by Double-Balloon EndoscopyCan J Gastroenterol Hepatol. 2021 Apr 14;2021:8875564. doi: 10.1155/2021/8875564. eCollection 2021.
    3. Honda T, Ishigami M, Yamamoto K, Takeyama T, Ito T, Ishizu Y, Kuzuya T, Nakamura M, Kawashima H, Miyahara R, Ishikawa T, Hirooka Y, Fujishiro M.Changes in the gut microbiota after hepatitis C virus eradicationSci Rep. 2021 Dec 7;11(1):23568. doi: 10.1038/s41598-021-03009-0.
    4. Ishikawa T, Kawashima H, Ohno E, Mizutani Y, Fujishiro M.Imaging diagnosis of autoimmune pancreatitis using endoscopic ultrasonographyJ Med Ultrason (2001). 2021 Oct;48(4):543-553. doi: 10.1007/s10396-021-01143-w. Epub 2021 Oct 20.
    5. Ishizu Y, Ishigami M, Honda T, Imai N, Ito T, Yamamoto K, Fujishiro M.Impact of visceral fat accumulation on the prognosis of patients with cirrhosisClin Nutr ESPEN. 2021 Apr;42:354-360. doi: 10.1016/j.clnesp.2021.01.008. Epub 2021 Jan 27.
    6. Ishikawa E, Satou A, Nakamura M, Nakamura S, Fujishiro M.Epstein-Barr Virus Positive B-Cell Lymphoproliferative Disorder of the Gastrointestinal TractCancers (Basel). 2021 Jul 29;13(15):3815. doi: 10.3390/cancers13153815.
    7. Shiroma S, Hatta W, Tsuji Y, Yoshio T, Yabuuchi Y, Hoteya S, Tsuji S, Nagami Y, Hikichi T, Kobayashi M, Morita Y, Sumiyoshi T, Iguchi M, Tomida H, Inoue T, Mikami T, Hasatani K, Nishikawa J, Matsumura T, Nebiki H, Nakamatsu D, Ohnita K, Suzuki H, Ueyama H, Hayashi Y, Sugimoto M, Yamaguchi S, Michida T, Yada T, Asahina Y, Narasaka T, Kuribayashi S, Kiyotoki S, Mabe K, Fujishiro M, Masamune A, Fujisaki J.Timing of bleeding and thromboembolism associated with endoscopic submucosal dissection for gastric cancer in JapanJ Gastroenterol Hepatol. 2021 Oct;36(10):2769-2777. doi: 10.1111/jgh.15536. Epub 2021 May 26.
    8. Sugiyama Y, Ishizu Y, Ando Y, Yokoyama S, Yamamoto K, Ito T, Imai N, Nakamura M, Honda T, Kawashima H, Ishikawa T, Ishigami M.Obesity and myosteatosis: the two characteristics of dynapenia in patients with cirrhosisEur J Gastroenterol Hepatol. 2021 Dec 1;33(1S Suppl 1):e916-e921. doi: 10.1097/MEG.0000000000002303.
    9. Nishikawa T, Maeda K, Nakamura M, Yamamura T, Sawada T, Mizutani Y, Ito T, Ishikawa T, Furukawa K, Ohno E, Miyahara R, Kawashima H, Honda T, Ishigami M, Yamamoto T, Matsumoto S, Hotta Y, Fujishiro M.Filtrated Adipose Tissue-Derived Mesenchymal Stem Cell Lysate Ameliorates Experimental Acute Colitis in MiceDig Dis Sci. 2021 Apr;66(4):1034-1044. doi: 10.1007/s10620-020-06359-3. Epub 2020 Jun 1.
    10. Uchida G, Nakamura M, Yamamura T, Furukawa K, Kawashima H, Honda T, Ishigami M, Fujishiro M.Systematic review and meta-analysis of the diagnostic and therapeutic yield of small bowel endoscopy in patients with overt small bowel bleedingDig Endosc. 2021 Jan;33(1):66-82. doi: 10.1111/den.13669. Epub 2020 Apr 30.
    11. Yoshikawa M, Ishikawa T, Ohno E, Iida T, Furukawa K, Nakamura M, Honda T, Ishigami M, Kinoshita F, Kawashima H, Fujishiro M.Variability measurements provide additional value to shear wave elastography in the diagnosis of pancreatic cancerSci Rep. 2021 Apr 1;11(1):7409. doi: 10.1038/s41598-021-86979-5.
    12. Yokoyama S, Ishizu Y, Ishigami M, Honda T, Kuzuya T, Ito T, Hinoki A, Sumida W, Shirota C, Tainaka T, Makita S, Yokota K, Uchida H, Fujishiro M.Factors associated with bleeding after endoscopic variceal ligation in childrenPediatr Int. 2021 Oct;63(10):1223-1229. doi: 10.1111/ped.14614. Epub 2021 Aug 20.
    13. Hirose T, Kakushima N, Furukawa K, Furune S, Ishikawa E, Sawada T, Maeda K, Yamamura T, Ishikawa T, Ohno E, Nakamura M, Nishida K, Yokoi T, Kawashima H, Fujishiro M.Endocytoscopy Is Useful for the Diagnosis of Superficial Nonampullary Duodenal Epithelial TumorsDigestion. 2021;102(6):895-902. doi: 10.1159/000516512. Epub 2021 Jun 7.
    14. Yamada K, Nakamura M, Yamamura T, Maeda K, Sawada T, Mizutani Y, Ishikawa E, Ishikawa T, Kakushima N, Furukawa K, Ohno E, Kawashima H, Honda T, Ishigami M, Fujishiro M.Diagnostic yield of colon capsule endoscopy for Crohn's disease lesions in the whole gastrointestinal tractBMC Gastroenterol. 2021 Feb 16;21(1):75. doi: 10.1186/s12876-021-01657-0.
    15. Esaki M, Yamamura T, Nakamura M, Maeda K, Sawada T, Mizutani Y, Ishikawa E, Furukawa K, Kawashima H, Hirooka Y, Fujishiro M.New modality for the quantitative evaluation of tissue elasticity using a forward-viewing radial-array echoendoscope for colorectal neoplasmsInt J Colorectal Dis. 2021 May;36(5):919-927. doi: 10.1007/s00384-020-03790-w. Epub 2020 Oct 28.
    16. Yamamoto T, Imai N, Yamamoto K, Ito T, Ishizu Y, Honda T, Okamoto S, Kanematsu T, Suzuki N, Matsushita T, Ishigami M, Fujishiro M.Safety and efficacy of percutaneous radiofrequency ablation for hepatocellular carcinoma patients with haemophiliaHaemophilia. 2021 Jan;27(1):100-107. doi: 10.1111/hae.14220. Epub 2020 Nov 27.
    17. Yamada K, Sawada T, Nakamura M, Yamamura T, Maeda K, Ishikawa E, Iida T, Mizutani Y, Kakushima N, Ishikawa T, Furukawa K, Ohno E, Honda T, Kawashima H, Ishigami M, Furune S, Hase T, Yokota K, Maeda O, Hashimoto N, Akiyama M, Ando Y, Fujishiro M.Clinical characteristics of gastrointestinal immune-related adverse events of immune checkpoint inhibitors and their association with survivalWorld J Gastroenterol. 2021 Nov 7;27(41):7190-7206. doi: 10.3748/wjg.v27.i41.7190.
    18. Ito T, Ishigami M, Yamamoto T, Mizuno K, Yamamoto K, Imai N, Ishizu Y, Honda T, Kawashima H, Yasuda S, Toyoda H, Yokota K, Hase T, Nishio N, Maeda O, Kato M, Hashimoto N, Hibi H, Kodera Y, Sone M, Ando Y, Akiyama M, Shimoyama Y, Fujishiro M.Clinical course of liver injury induced by immune checkpoint inhibitors in patients with advanced malignanciesHepatol Int. 2021 Oct;15(5):1278-1287. doi: 10.1007/s12072-021-10238-y. Epub 2021 Aug 9.
    19. Furukawa K, Nakamura M, Kawashima H, Fujishiro M.Endoscopic resection of a duodenal neuroendocrine tumorRev Esp Enferm Dig. 2021 Sep 2. doi: 10.17235/reed.2021.8232/2021. Online ahead of print.
    20. Yamamoto K, Honda T, Yokoyama S, Ma L, Kato A, Ito T, Ishizu Y, Kuzuya T, Nakamura M, Kawashima H, Ishigami M, Tsuji NM, Fujishiro M.Microbiome, fibrosis and tumor networks in a non-alcoholic steatohepatitis model of a choline-deficient high-fat diet using diethylnitrosamineDig Liver Dis. 2021 Nov;53(11):1443-1450. doi: 10.1016/j.dld.2021.02.013. Epub 2021 Mar 13.
    21. Saito M, Yamamura T, Nakamura M, Maeda K, Sawada T, Ishikawa E, Mizutani Y, Ishikawa T, Kakushima N, Furukawa K, Ohno E, Kawashima H, Ishigami M, Fujishiro M.Real-world local recurrence rate after cold polypectomy in colorectal polyps less than 10 mm using propensity score matchingWorld J Gastroenterol. 2021 Dec 21;27(47):8182-8193. doi: 10.3748/wjg.v27.i47.8182.
    22. Honda T, Yamada N, Murayama A, Shiina M, Aly HH, Kato A, Ito T, Ishizu Y, Kuzuya T, Ishigami M, Murakami Y, Tanaka T, Moriishi K, Nishitsuji H, Shimotohno K, Ishikawa T, Fujishiro M, Muramatsu M, Wakita T, Kato T.Amino Acid Polymorphism in Hepatitis B Virus Associated With Functional CureCell Mol Gastroenterol Hepatol. 2021;12(5):1583-1598. doi: 10.1016/j.jcmgh.2021.07.013. Epub 2021 Aug 2.
    23. Suzuki T, Furukawa K, Funasaka K, Ishikawa E, Sawada T, Maeda K, Yamamura T, Ishikawa T, Ohno E, Nakamura M, Kawashima H, Miyahara R, Fujishiro M.Long-Term Prognostic Predictors of Esophageal Squamous Cell Carcinoma Potentially Indicated for Endoscopic Submucosal DissectionDigestion. 2021;102(4):563-571. doi: 10.1159/000510091. Epub 2020 Sep 7.
    24. Uetsuki K, Kawashima H, Ohno E, Ishikawa T, Iida T, Yamamoto K, Furukawa K, Nakamura M, Honda T, Ishigami M, Hirooka Y, Fujishiro M.Measurement of fasting breath hydrogen concentration as a simple diagnostic method for pancreatic exocrine insufficiencyBMC Gastroenterol. 2021 May 10;21(1):211. doi: 10.1186/s12876-021-01776-8.
    25. Kataoka K, Ishikawa T, Ohno E, Mizutani Y, Iida T, Ishikawa E, Furukawa K, Nakamura M, Honda T, Ishigami M, Kawashima H, Hirooka Y, Fujishiro M.Differentiation between pancreatic metastases from renal cell carcinoma and pancreatic neuroendocrine neoplasm using endoscopic ultrasoundPancreatology. 2021 Oct;21(7):1364-1370. doi: 10.1016/j.pan.2021.07.001. Epub 2021 Jul 14.
    26. Nishikawa T, Nakamura M, Yamamura T, Maeda K, Sawada T, Mizutani Y, Ishikawa E, Ishikawa T, Kakushima N, Furukawa K, Ohno E, Honda T, Kawashima H, Ishigami M, Fujishiro M.Lewis score on capsule endoscopy can predict the prognosis in patients with small bowel lesions of Crohn's diseaseJ Gastroenterol Hepatol. 2021 Jul;36(7):1851-1858. doi: 10.1111/jgh.15366. Epub 2020 Dec 22.
    27. Otsuka H, Nakamura M, Yamamura T, Maeda K, Sawada T, Mizutani Y, Ishikawa E, Ishikawa T, Kakushima N, Furukawa K, Ohno E, Kawashima H, Honda T, Ishigami M, Fujishiro M.Feasibility of patency capsule and colon capsule endoscopy in patients with suspected gastrointestinal stenosis: a prospective studyNagoya J Med Sci. 2021 Aug;83(3):419-430. doi: 10.18999/nagjms.83.3.419.
    28. Ishikawa T, Kawashima H, Ohno E, Iida T, Suzuki H, Uetsuki K, Yashika J, Yamada K, Yoshikawa M, Gibo N, Aoki T, Kataoka K, Mori H, Yamamura T, Furukawa K, Nakamura M, Hirooka Y, Fujishiro M.Clinical characteristics and long-term prognosis of autoimmune pancreatitis with renal lesionsSci Rep. 2021 Jan 11;11(1):406. doi: 10.1038/s41598-020-79899-3.
    29. Matsuzaki I, Ebara T, Tsunemi M, Hatta Y, Yamamoto K, Baba A, Hattori M, Nakamura M, Fujishiro M.Effects of endoscopy-related procedure time on musculoskeletal disorders in Japanese endoscopists: a cross-sectional studyEndosc Int Open. 2021 May;9(5):E674-E683. doi: 10.1055/a-1352-3850. Epub 2021 Apr 22.
    30. Kataoka K, Ishikawa T, Ohno E, Iida T, Suzuki H, Uetsuki K, Furukawa K, Nakamura M, Honda T, Ishigami M, Kawashima H, Hirooka Y, Fujishiro M.Endoscopic ultrasound elastography for small solid pancreatic lesions with or without main pancreatic duct dilatationPancreatology. 2021 Mar;21(2):451-458. doi: 10.1016/j.pan.2020.12.012. Epub 2020 Dec 31.
    31. Nishida T, Nikura R, Nagata N, Honda T, Sunagozaka H, Shiratori Y, Tsuji S, Sumiyoshi T, Fujita T, Kiyotoki S, Yada T, Yamamoto K, Shinozaki T, Nakamatsu D, Yamada A, Fujishiro M.Feasibility and safety of colonoscopy performed by nonexperts for acute lower gastrointestinal bleeding: post hoc analysisEndosc Int Open. 2021 Jun;9(6):E943-E954. doi: 10.1055/a-1464-0809. Epub 2021 May 27.
    32. Suzuki H, Ishikawa T, Ohno E, Iida T, Uetsuki K, Yashika J, Yamada K, Yoshikawa M, Furukawa K, Nakamura M, Honda T, Ishigami M, Kawashima H, Fujishiro M.An initial trial of quantitative evaluation of autoimmune pancreatitis using shear wave elastography and shear wave dispersion in transabdominal ultrasoundPancreatology. 2021 Jun;21(4):682-687. doi: 10.1016/j.pan.2021.02.014. Epub 2021 Feb 20.
    33. Nagami Y, Hatta W, Tsuji Y, Yoshio T, Kakushima N, Hoteya S, Tsuji S, Fukunaga S, Hikichi T, Kobayashi M, Morita Y, Sumiyoshi T, Iguchi M, Tomida H, Inoue T, Mikami T, Hasatani K, Nishikawa J, Matsumura T, Nebiki H, Nakamatsu D, Ohnita K, Suzuki H, Ueyama H, Hayashi Y, Yoshida H, Fujishiro M, Masamune A, Fujiwara Y; Fight-Japan study group.Antithrombotics increase bleeding after endoscopic submucosal dissection for gastric cancer: Nationwide propensity score analysisDig Endosc. 2021 Sep 26. doi: 10.1111/den.14151. Online ahead of print.
    34. Kuno T, Yamamura T, Nakamura M, Maeda K, Sawada T, Mizutani Y, Esaki M, Ishikawa T, Furukawa K, Ohno E, Kawashima H, Fujishiro M.A forward-viewing radial-array echoendoscope is useful for diagnosing the depth of colorectal neoplasia invasionSurg Endosc. 2021 Aug;35(8):4389-4398. doi: 10.1007/s00464-020-07936-3. Epub 2020 Sep 2.
    35. Kawano T, Souzaki R, Sumida W, Ishimaru T, Fujishiro J, Hishiki T, Kinoshita Y, Kawashima H, Uchida H, Tajiri T, Yoneda A, Oue T, Kuroda T, Koshinaga T, Hiyama E, Nio M, Inomata Y, Taguchi T, Ieiri S.Laparoscopic approach for abdominal neuroblastoma in Japan: results from nationwide multicenter surveySurg Endosc. 2021 Jun 18. doi: 10.1007/s00464-021-08599-4. Online ahead of print.
    36. Tsuji Y, Ushiku T, Shinozaki T, Yamashita H, Seto Y, Fukayama M, Fujishiro M, Oda I, Katai H, Taniguchi H, Hasatani K, Kaizaki Y, Oga A, Nishikawa J, Akasaka R, Endo M, Sugai T, Matsumoto T, Koike K.Risk for lymph node metastasis in Epstein-Barr virus-associated gastric carcinoma with submucosal invasionDig Endosc. 2021 May;33(4):592-597. doi: 10.1111/den.13823. Epub 2020 Oct 19.
    37. Yamamoto K, Honda T, Ito T, Ishizu Y, Kuzuya T, Nakamura M, Miyahara R, Kawashima H, Ishigami M, Fujishiro M.The relationship between oral-origin bacteria in the fecal microbiome and albumin-bilirubin grade in patients with hepatitis CJ Gastroenterol Hepatol. 2021 Mar;36(3):790-799. doi: 10.1111/jgh.15206. Epub 2020 Aug 14.
    38. Yoshida K, Desbiolles A, Feldman SF, Ahn SH, Alidjinou EK, Atsukawa M, Bocket L, Brunetto MR, Buti M, Carey I, Caviglia GP, Chen EQ, Cornberg M, Enomoto M, Honda M, Zu Siederdissen CH, Ishigami M, Janssen HLA, Maasoumy B, Matsui T, Matsumoto A, Nishiguchi S, Riveiro-Barciela M, Takaki A, Tangkijvanich P, Toyoda H, van Campenhout MJH, Wang B, Wei L, Yang HI, Yano Y, Yatsuhashi H, Yuen MF, Tanaka E, Lemoine M, Tanaka Y, Shimakawa Y.Hepatitis B Core-Related Antigen to Indicate High Viral Load: Systematic Review and Meta-Analysis of 10,397 Individual ParticipantsClin Gastroenterol Hepatol. 2021 Jan;19(1):46-60.e8. doi: 10.1016/j.cgh.2020.04.045. Epub 2020 Apr 29.
    39. Matsuda N, Imai N, Kuzuya T, Yamamoto K, Ito T, Ishizu Y, Honda T, Ishigami M, Fujishiro M.Progression After Molecular Targeted Agents: Hepatic Arterial Changes and Transarterial Chemoembolization in Hepatocellular CarcinomaIn Vivo. 2021 Mar-Apr;35(2):1185-1189. doi: 10.21873/invivo.12367.
    40. Toriyama K, Yamamura T, Nakamura M, Maeda K, Sawada T, Mizutani Y, Ishikawa E, Furukawa K, Ishikawa T, Ohno E, Kawashima H, Fujishiro M.An evaluation of resectability among endoscopic treatment methods for rectalneuroendocrine tumors <10 mmArab J Gastroenterol. 2021 Jun;22(2):104-110. doi: 10.1016/j.ajg.2021.05.007. Epub 2021 May 28.
    41. Tanaka H, Kawashima H, Ohno E, Ishikawa T, Iida T, Ishikawa E, Furukawa K, Nakamura M, Honda T, Shimoyama Y, Miyahara R, Kawabe N, Kuzuya T, Hashimoto S, Ishigami M, Hirooka Y, Fujishiro M.Immunohistochemical staining for IMP3 in patients with duodenal papilla tumors: assessment of the potential for diagnosing endoscopic resectability and predicting prognosisBMC Gastroenterol. 2021 May 18;21(1):224. doi: 10.1186/s12876-021-01811-8.
    42. Ito T, Ishigami M, Zou B, Tanaka T, Takahashi H, Kurosaki M, Maeda M, Thin KN, Tanaka K, Takahashi Y, Itoh Y, Oniki K, Seko Y, Saruwatari J, Kawanaka M, Atsukawa M, Hyogo H, Ono M, Ogawa E, Barnett SD, Stave CD, Cheung RC, Fujishiro M, Eguchi Y, Toyoda H, Nguyen MH.The epidemiology of NAFLD and lean NAFLD in Japan: a meta-analysis with individual and forecasting analysis, 1995-2040Hepatol Int. 2021 Apr;15(2):366-379. doi: 10.1007/s12072-021-10143-4. Epub 2021 Feb 12.
    43. Nakamura M, Yano T, Esaki M, Oka S, Mitsui K, Hirai F, Kawasaki K, Fujishiro M, Torisu T, Tanaka S, Iwakiri K, Kishi M, Matsumoto T, Yamamoto H.Novel ultrathin double-balloon endoscopy for the diagnosis of small-bowel diseases: a multicenter nonrandomized studyEndoscopy. 2021 Aug;53(8):802-814. doi: 10.1055/a-1243-0226. Epub 2020 Sep 9.
    44. Hasegawa I, Yamamura T, Suzuki H, Maeda K, Sawada T, Mizutani Y, Ishikawa E, Ishikawa T, Kakushima N, Furukawa K, Ohno E, Kawashima H, Nakamura M, Fujishiro M.Detection of Colorectal Neoplasms Using Linked Color Imaging: A Prospective, Randomized, Tandem Colonoscopy TrialClin Gastroenterol Hepatol. 2021 Aug;19(8):1708-1716.e4. doi: 10.1016/j.cgh.2021.04.004. Epub 2021 Apr 8.
    45. Yamamoto T, Imai N, Yamamoto K, Ito T, Ishizu Y, Honda T, Okamoto S, Kanematsu T, Suzuki N, Matsushita T, Ishigami M, Fujishiro M.Tolerability of Molecular-targeted Agents for Hepatocellular Carcinoma Treatment in HaemophiliacsAnticancer Res. 2021 May;41(5):2569-2573. doi: 10.21873/anticanres.15035.
    46. Muroi K, Miyahara R, Funasaka K, Furukawa K, Sawada T, Maeda K, Yamamura T, Ishikawa T, Ohno E, Nakamura M, Kawashima H, Onoue T, Arima H, Hirooka Y, Fujishiro M.Comparison of High-Resolution Manometry in Patients Complaining of Dysphagia among Patients with or without Diabetes MellitusDigestion. 2021;102(4):554-562. doi: 10.1159/000510081. Epub 2020 Sep 9.
    47. Yamada K, Ishikawa T, Ohno E, Iida T, Suzuki H, Uetsuki K, Yashika J, Yoshikawa M, Takami H, Inokawa Y, Uchida H, Kawashima H, Fujishiro M.Double common bile duct associated with pancreaticobiliary maljunctionNagoya J Med Sci. 2021 Aug;83(3):655-661. doi: 10.18999/nagjms.83.3.655.
    48. Hashimoto M, Hatta W, Tsuji Y, Yoshio T, Yabuuchi Y, Hoteya S, Doyama H, Nagami Y, Hikichi T, Kobayashi M, Morita Y, Sumiyoshi T, Iguchi M, Tomida H, Inoue T, Mikami T, Hasatani K, Nishikawa J, Matsumura T, Nebiki H, Nakamatsu D, Ohnita K, Suzuki H, Ueyama H, Hayashi Y, Sugimoto M, Fujishiro M, Masamune A, Ohira H; Collaborators.Rebleeding in patients with delayed bleeding after endoscopic submucosal dissection for early gastric cancerDig Endosc. 2021 Nov;33(7):1120-1130. doi: 10.1111/den.13943. Epub 2021 Mar 17.
    49. Yashika J, Ohno E, Ishikawa T, Iida T, Suzuki H, Uetsuki K, Yamada K, Yoshikawa M, Gibo N, Shimoyama Y, Ishikawa E, Furukawa K, Nakamura M, Honda T, Ishigami M, Hirooka Y, Kawashima H, Fujishiro M.Utility of multiphase contrast enhancement patterns on CEH-EUS for the differential diagnosis of IPMN-derived and conventional pancreatic cancerPancreatology. 2021 Mar;21(2):390-396. doi: 10.1016/j.pan.2020.12.022. Epub 2021 Jan 12.
    50. Ohno E, Kawashima H, Ishikawa T, Iida T, Suzuki H, Uetsuki K, Yashika J, Yamada K, Yoshikawa M, Gibo N, Aoki T, Kataoka K, Mori H, Yamamura T, Furukawa K, Nakamura M, Hirooka Y, Fujishiro M.Diagnostic performance of endoscopic ultrasonography-guided elastography for solid pancreatic lesions: Shear-wave measurements versus strain elastography with histogram analysisDig Endosc. 2021 May;33(4):629-638. doi: 10.1111/den.13791. Epub 2020 Sep 15.
    51. Esaki M, Yamamura T, Nakamura M, Maeda K, Sawada T, Mizutani Y, Ishikawa E, Suzuki H, Kuno T, Yamada K, Hasegawa I, Ishikawa T, Kakushima N, Furukawa K, Ohno E, Kawashima H, Hirooka Y, Fujishiro M.Endoscopic Ultrasound Elastography as a Novel Diagnostic Method for the Assessment of Hardness and Depth of Invasion in Colorectal NeoplasmsDigestion. 2021;102(5):701-713. doi: 10.1159/000511589. Epub 2020 Nov 18.
    52. Ito N, Funasaka K, Furukawa K, Kakushima N, Hirose T, Muroi K, Suzuki T, Suzuki T, Hida E, Ishikawa T, Yamamura T, Ohno E, Nakamura M, Kawashima H, Miyahara R, Fujishiro M.A novel scoring system to predict therapeutic intervention for non-variceal upper gastrointestinal bleedingIntern Emerg Med. 2021 Aug 7. doi: 10.1007/s11739-021-02822-9. Online ahead of print.
    53. Tsutsumi K, Kato M, Kakushima N, Iguchi M, Yamamoto Y, Kanetaka K, Uraoka T, Fujishiro M, Sho M; Japan Duodenal Cancer Guideline Committee.Efficacy of endoscopic preventive procedures to reduce delayed adverse events after endoscopic resection of superficial nonampullary duodenal epithelial tumors: a meta-analysis of observational comparative trialsGastrointest Endosc. 2021 Feb;93(2):367-374.e3. doi: 10.1016/j.gie.2020.08.017. Epub 2020 Aug 22.
    54. Kawashima H, Ohno E, Ishikawa T, Iida T, Tanaka H, Furukawa K, Nakamura M, Honda T, Hashimoto S, Itoh A, Ishigami M, Hirooka Y, Fujishiro M.Endoscopic papillectomy for ampullary adenoma and early adenocarcinoma: Analysis of factors related to treatment outcome and long-term prognosisDig Endosc. 2021 Jul;33(5):858-869. doi: 10.1111/den.13881. Epub 2020 Dec 28.
    55. Yoshioka N, Tanaka M, Ochi K, Watanabe A, Ono K, Sawada M, Ogi T, Itoh M, Ito A, Shiraki Y, Enomoto A, Ishigami M, Fujishiro M, Ogawa Y, Suganami T.The sodium-glucose cotransporter-2 inhibitor Tofogliflozin prevents the progression of nonalcoholic steatohepatitis-associated liver tumors in a novel murine modelBiomed Pharmacother. 2021 Aug;140:111738. doi: 10.1016/j.biopha.2021.111738. Epub 2021 May 21.
    56. Muto H, Ito T, Tanaka T, Yokoyama S, Yamamoto K, Imai N, Ishizu Y, Maeda K, Honda T, Ishikawa T, Kato A, Ohshiro T, Kano F, Yamamoto A, Sakai K, Hibi H, Ishigami M, Fujishiro M.Conditioned medium from stem cells derived from human exfoliated deciduous teeth ameliorates NASH via the Gut-Liver axisSci Rep. 2021 Sep 21;11(1):18778. doi: 10.1038/s41598-021-98254-8.
    57. Aoki T, Yamada A, Kato Y, Saito H, Tsuboi A, Nakada A, Niikura R, Fujishiro M, Oka S, Ishihara S, Matsuda T, Nakahori M, Tanaka S, Koike K, Tada T.Automatic detection of various abnormalities in capsule endoscopy videos by a deep learning-based system: a multicenter studyGastrointest Endosc. 2021 Jan;93(1):165-173.e1. doi: 10.1016/j.gie.2020.04.080. Epub 2020 May 15.
    58. Suzuki H, Ishikawa T, Ohno E, Kawashima H, Fujishiro M.Gastrointestinal: Pancreatic metastasis from extramammary Paget's disease diagnosed by endoscopic ultrasound-guided fine-needle biopsyJ Gastroenterol Hepatol. 2021 Nov;36(11):3000. doi: 10.1111/jgh.15444. Epub 2021 Mar 15.
    59. Kiyotoki S, Nishikawa J, Nagata N, Niikura R, Doyama H, Imagawa A, Hasatani K, Hatta W, Sumiyoshi T, Nebiki H, Nagami Y, Nishida T, Kakushima N, Iguchi M, Tomida H, Inoue T, Kuribayashi S, Narasaka T, Hikichi T, Yada T, Ochiai Y, Furuhashi H, Yoshio T, Mori H, Yamauchi K, Kitamura K, Fujita T, Mabe K, Mikami T, Goto A, Akashi M, Hamamoto Y, Fujishiro M, Sakaida I.Exploration of the characteristics of chronotypes in upper gastrointestinal tract diseases: a multicenter study in JapanChronobiol Int. 2021 Apr;38(4):534-542. doi: 10.1080/07420528.2020.1830791. Epub 2020 Oct 15.
    60. Kobayashi K, Furukawa K, Ishikawa E, Mitsuma A, Funasaka K, Kakushima N, Furune S, Ito N, Wada H, Hirose T, Muroi K, Suzuki T, Suzuki T, Hida E, Hirai K, Shibata H, Koya T, Nakamura M, Kawashima H, Miyahara R, Fujishiro M.Collision Tumors of Gastric Adenocarcinoma and Mucosa-associated Lymphoid Tissue LymphomaIntern Med. 2021;60(15):2419-2424. doi: 10.2169/internalmedicine.6124-20. Epub 2021 Aug 1.
    61. Ishizu Y, Ishigami M, Honda T, Kuzuya T, Ito T, Komada T, Fujishiro M.Simplification of balloon-occluded retrograde transcatheter obliteration procedure using a coaxial double balloon catheter compared with a single-balloon catheterJpn J Radiol. 2021 Mar;39(3):296-302. doi: 10.1007/s11604-020-01060-x. Epub 2020 Oct 31.
    62. Muroi K, Kakushima N, Furukawa K, Ishikawa E, Sawada T, Ishikawa T, Maeda K, Yamamura T, Ohno E, Nakamura M, Kawashima H, Funasaka K, Miyahara R, Fujishiro M.Subjective Symptoms in Patients with Eosinophilic Esophagitis Are Related to Esophageal Wall Thickness and Esophageal Body PressureDig Dis Sci. 2021 Jul;66(7):2291-2300. doi: 10.1007/s10620-020-06527-5. Epub 2020 Aug 8.
    63. Yoshida M, Yabuuchi Y, Kakushima N, Kato M, Iguchi M, Yamamoto Y, Kanetaka K, Uraoka T, Fujishiro M, Sho M; Japan Duodenal Cancer Guideline Committee.The incidence of non-ampullary duodenal cancer in Japan: The first analysis of a national cancer registryJ Gastroenterol Hepatol. 2021 May;36(5):1216-1221. doi: 10.1111/jgh.15285. Epub 2020 Oct 9.
    64. Ishikawa E, Nakaguro M, Nakamura M, Yamamura T, Sawada T, Mizutani Y, Maeda K, Furukawa K, Shimoyama Y, Kawashima H, Fujishiro M.Gastrointestinal tract metastasis of lung cancer: The PD-L1 expression and correlated clinicopathological variablesPathol Int. 2021 Jan;71(1):33-41. doi: 10.1111/pin.13048. Epub 2020 Dec 1.
    65. Furukawa K, Sato K, Okachi S, Kawashima H, Fujishiro M.Surgical mask designed for endoscopic procedures to prevent the diffusion of dropletsActa Gastroenterol Belg. 2021 Jul-Sep;84(3):517-519. doi: 10.51821/84.3.024.
    66. Imai N, Yokoyama S, Yamamoto K, Ito T, Ishizu Y, Honda T, Ishigami M.Safety and Efficacy of Glass Membrane Pumping Emulsification Device in Transarterial Chemoembolization for Hepatocellular Carcinoma: First Clinical OutcomesAnticancer Res. 2021 Nov;41(11):5817-5820. doi: 10.21873/anticanres.15399.
    67. Ozawa N, Sato K, Sugimura A, Maki S, Tanaka T, Yamamoto K, Ito T, Ishizu Y, Kuzuya T, Honda T, Ishigami M, Fujishiro M, Ishikawa T, Ando S.Quality of Life in patients with nonalcoholic fatty liver disease: Structure and related factors focusing on illness uncertaintyJpn J Nurs Sci. 2021 Mar 11:e12415. doi: 10.1111/jjns.12415. Online ahead of print.
    68. Ishigami M, Honda T, Ishizu Y, Imai N, Ito T, Yamamoto K, Kamei H, Ogura Y, Fujishiro M.Revisiting Prognosis After Liver Transplant in Patients Positive for Hepatitis C Virus: Focus on Hepatitis C Recurrence-Unrelated ComplicationsExp Clin Transplant. 2021 Sep;19(9):935-942. doi: 10.6002/ect.2021.0197.
    69. Muto H, Kuzuya T, Ito T, Ishizu Y, Honda T, Ishikawa T, Ishigami M, Fujishiro M.Transient deterioration of albumin-bilirubin scores in early post-dose period of molecular targeted therapies in advanced hepatocellular carcinoma with 50% or higher liver occupation: A STROBE-compliant retrospective observational studyMedicine (Baltimore). 2021 Aug 6;100(31):e26820. doi: 10.1097/MD.0000000000026820.
    70. Zhao R, Nakamura M, Wu S, Uchida G, Yamamura T, Gao YJ, Goto H, Fujishiro M, Ge ZZ.The role of early video capsule endoscopy in the diagnosis and prognosis of obscure gastrointestinal bleeding: A multi-center propensity score matching studyJ Gastroenterol Hepatol. 2021 Sep;36(9):2540-2548. doi: 10.1111/jgh.15491. Epub 2021 Apr 14.
    71. Tomida H, Yoshio T, Igarashi K, Morita Y, Oda I, Inoue T, Hikichi T, Sumiyoshi T, Doyama H, Tsuji Y, Nishikawa J, Hatta W, Mikami T, Iguchi M, Sumiyama K, Yamamoto K, Kitamura K, Kuribayashi S, Yanagitani A, Uraoka T, Yada T, Hasatani K, Kawaguchi K, Fujita T, Nishida T, Hiasa Y, Fujishiro M; FIGHT-Japan Study Group.Influence of anticoagulants on the risk of delayed bleeding after gastric endoscopic submucosal dissection: a multicenter retrospective studyGastric Cancer. 2021 Jan;24(1):179-189. doi: 10.1007/s10120-020-01105-0. Epub 2020 Jul 18.
    72. Niikura R, Fujishiro M, Nakai Y, Matsuda K, Kawahara T, Yamada A, Tsuji Y, Hayakawa Y, Koike K.International Observational Survey of the Effectiveness of Personal Protective Equipment during Endoscopic Procedures Performed in Patients with COVID-19Digestion. 2021;102(6):845-853. doi: 10.1159/000513714. Epub 2021 Feb 16.
    73. Amano H, Shirota C, Tainaka T, Sumida W, Yokota K, Makita S, Takimoto A, Tanaka Y, Hinoki A, Kawashima H, Uchida H.Late postoperative complications of congenital biliary dilatation in pediatric patients: a single-center experience of managing complications for over 20 yearsSurg Today. 2021 Sep;51(9):1488-1495. doi: 10.1007/s00595-021-02238-0. Epub 2021 Mar 10.
    74. Takada Y, Ishikawa T, Kawashima H.An Unusual Pancreatic Mass with Ductal Disruption: Benign or Malignant?Gastroenterology. 2021 Oct;161(4):1113-1115. doi: 10.1053/j.gastro.2021.06.059. Epub 2021 Jun 26.
    75. Murate K, Nakamura M, Yamamura T, Maeda K, Sawada T, Mizutani Y, Ishikawa E, Kakushima N, Furukawa K, Ohno E, Honda T, Kawashima H, Ishigami M, Fujishiro M.Ustekinumab is effective against small bowel lesions in Crohn's disease: two case reportsClin J Gastroenterol. 2021 Feb;14(1):129-135. doi: 10.1007/s12328-020-01242-0. Epub 2020 Oct 28.
    76. Yabuuchi Y, Hatta W, Tsuji Y, Yoshio T, Kakushima N, Hoteya S, Doyama H, Nagami Y, Hikichi T, Kobayashi M, Morita Y, Sumiyoshi T, Iguchi M, Tomida H, Inoue T, Mikami T, Hasatani K, Nishikawa J, Matsumura T, Nebiki H, Nakamatsu D, Ohnita K, Suzuki H, Ueyama H, Hayashi Y, Sugimoto M, Yamaguchi S, Michida T, Yada T, Asahina Y, Narasaka T, Kuribayashi S, Kiyotoki S, Mabe K, Fujishiro M, Masamune A, Ono H.Influence of hospital volume on bleeding after endoscopic submucosal dissection for early gastric cancer in Japan: a multicenter propensity score-matched analysisSurg Endosc. 2021 Sep 7. doi: 10.1007/s00464-021-08721-6. Online ahead of print.
    77. Ishikawa T, Ohno E, Mizutani Y, Iida T, Koya T, Sasaki Y, Ogawa H, Kinoshita F, Hirooka Y, Kawashima H.Comparison of contrast-enhanced transabdominal ultrasonography following endoscopic ultrasonography with GD-EOB-DTPA-enhanced MRI for the sequential diagnosis of liver metastasis in patients with pancreatic cancerJ Hepatobiliary Pancreat Sci. 2021 Dec 8. doi: 10.1002/jhbp.1097. Online ahead of print.
    78. Shimada M, Hirashima N, Iwase H, Saito M, Kondo H, Urata N, Unita S, Kondo T, Tanaka D, Tsunekawa T, Fujishiro M.Evaluation of Muscle Cramp Associated with Liver Cirrhosis with a Focus on the Liver Function and Nutritional StatusIntern Med. 2021 May 1;60(9):1343-1348. doi: 10.2169/internalmedicine.6231-20. Epub 2020 Dec 7.
    79. Shirota C, Kawashima H, Tainaka T, Sumida W, Yokota K, Makita S, Amano H, Takimoto A, Hinoki A, Uchida H.Double-balloon endoscopic retrograde cholangiography can make a reliable diagnosis and good prognosis for postoperative complications of congenital biliary dilatationSci Rep. 2021 May 26;11(1):11052. doi: 10.1038/s41598-021-90550-7.
    80. Ishikawa T, Kawashima H, Ohno E, Nakamura M, Yamada S, Hayashi M, Fujishiro M.Endoscopic removal of a fish bone piercing the bile duct after pancreaticoduodenectomyEndoscopy. 2021 May;53(5):E164-E165. doi: 10.1055/a-1224-3724. Epub 2020 Aug 20.
    81. Sugimoto M, Hatta W, Tsuji Y, Yoshio T, Yabuuchi Y, Hoteya S, Doyama H, Nagami Y, Hikichi T, Kobayashi M, Morita Y, Sumiyoshi T, Iguchi M, Tomida H, Inoue T, Mikami T, Hasatani K, Nishikawa J, Matsumura T, Nebiki H, Nakamatsu D, Ohnita K, Suzuki H, Ueyama H, Hayashi Y, Murata M, Yamaguchi S, Michida T, Yada T, Asahina Y, Narasaka T, Kuribayashi S, Kiyotoki S, Mabe K, Fujishiro M, Masamune A, Kawai T.Risk Factors for Bleeding After Endoscopic Submucosal Dissection for Gastric Cancer in Elderly Patients Older Than 80 Years in JapanClin Transl Gastroenterol. 2021 Sep 24;12(9):e00404. doi: 10.14309/ctg.0000000000000404.
    82. Nishida T, Niikura R, Nagata N, Honda T, Sunagozaka H, Shiratori Y, Tsuji S, Sumiyoshi T, Fujita T, Kiyotoki S, Yada T, Yamamoto K, Shinozaki T, Nakamatsu D, Yamada A, Fujishiro M.Erratum: Feasibility and safety of colonoscopy performed by nonexperts for acute lower gastrointestinal bleeding: post hoc analysisEndosc Int Open. 2021 Oct 13;9(6):C10. doi: 10.1055/a-1548-4517. eCollection 2021 Jun.
    83. Yamamoto T, Hamajima E, Kamioka T, Nakae Y, Nakashima S, Kuno T, Ito M, Fujishiro M.[A case of mucosal prolapse syndrome complicated by well-differentiated tubular adenocarcinoma and high-grade adenoma after long-term follow-up by colonoscopy]Nihon Shokakibyo Gakkai Zasshi. 2021;118(8):757-767. doi: 10.11405/nisshoshi.118.757.
    84. Shimada M, Hirashima N, Iwase H, Saito M, Kondo H, Urata N, Unita S, Kondo T, Tanaka D, Tsunekawa T, Nakamura S, Nishikura M, Miyazawa K, Fukuhara K, Fujishiro M.Evaluating patient acceptability and bowel preparation efficacy of sodium picosulfate-magnesium citrate for colonoscopyDEN open. 2021 Sep 28;2(1):e59. doi: 10.1002/deo2.59. eCollection 2022 Apr.
    85. Sakamoto Y, Yoshio S, Doi H, Mori T, Matsuda M, Kawai H, Shimagaki T, Yoshikawa S, Aoki Y, Osawa Y, Yoshida Y, Arai T, Itokawa N, Atsukawa M, Ito T, Honda T, Mise Y, Ono Y, Takahashi Y, Saiura A, Taketomi A, Kanto T.Increased Frequency of Dysfunctional Siglec-7(-)CD57(+)PD-1(+) Natural Killer Cells in Patients With Non-alcoholic Fatty Liver DiseaseFront Immunol. 2021 Feb 22;12:603133. doi: 10.3389/fimmu.2021.603133. eCollection 2021.
    86. Nakamura M, Watanabe K, Ohmiya N, Hirai F, Omori T, Tokuhara D, Nakaji K, Nouda S, Esaki M, Sameshima Y, Goto H, Terano A, Tajiri H, Matsui T; J-POP study group.Tag-less patency capsule for suspected small bowel stenosis: Nationwide multicenter prospective study in JapanDig Endosc. 2021 Jan;33(1):151-161. doi: 10.1111/den.13673. Epub 2020 Jun 24.
    87. Kita T, Ashizuka S, Ohmiya N, Yamamoto T, Kanai T, Motoya S, Hirai F, Nakase H, Moriyama T, Nakamura M, Suzuki Y, Kanmura S, Kobayashi T, Ohi H, Nozaki R, Mitsuyama K, Yamamoto S, Inatsu H, Watanabe K, Hibi T, Kitamura K.Adrenomedullin for steroid-resistant ulcerative colitis: a randomized, double-blind, placebo-controlled phase-2a clinical trialJ Gastroenterol. 2021 Feb;56(2):147-157. doi: 10.1007/s00535-020-01741-4. Epub 2020 Nov 2.
    88. Watanabe K, Ohmiya N, Nakamura M, Fujiwara Y.A Prospective Study Evaluating the Clinical Utility of the Tag-Less Patency Capsule with Extended Time for Confirming Functional PatencyDigestion. 2021;102(2):180-187. doi: 10.1159/000503027. Epub 2019 Sep 19.
    89. Yamashita K, Yube Y, Yamazaki Y, Fukuchi T, Kato M, Koike T, Uehara T, Ikeda Y, Furune S, Murakami H, Kubota E, Fujioka S, Sato Y, Jin X, Suzuki T, Furukawa K, Tsuboi Y.The impact of tube replacement timing during LCIG therapy on PEG-J associated adverse events: a retrospective multicenter observational studyBMC Neurol. 2021 Jun 25;21(1):242. doi: 10.1186/s12883-021-02269-7.
    90. Ohno E.Paradigm shift in image-enhanced endoscopic ultrasonographyDig Endosc. 2021 Jul;33(5):751-752. doi: 10.1111/den.13906. Epub 2020 Dec 31.
    91. Ohno E, Hirooka Y.Encyclopedia of autoimmune pancreatitis: this is all we needJ Med Ultrason (2001). 2021 Oct;48(4):523-524. doi: 10.1007/s10396-021-01150-x. Epub 2021 Nov 10.
    92. Kitano M, Yamashita Y, Kamata K, Ang TL, Imazu H, Ohno E, Hirooka Y, Fusaroli P, Seo DW, Napoleon B, Teoh AYB, Kim TH, Dietrich CF, Wang HP, Kudo M; Working group for the International Consensus Guidelines for Contrast-Enhanced Harmonic Endoscopic Ultrasound.The Asian Federation of Societies for Ultrasound in Medicine and Biology (AFSUMB) Guidelines for Contrast-Enhanced Endoscopic UltrasoundUltrasound Med Biol. 2021 Jun;47(6):1433-1447. doi: 10.1016/j.ultrasmedbio.2021.01.030. Epub 2021 Feb 27.
    93. Li Y, Imai N, Nicholls HT, Roberts BR, Goyal S, Krisko TI, Ang LH, Tillman MC, Roberts AM, Baqai M, Ortlund EA, Cohen DE, Hagen SJ.Thioesterase superfamily member 1 undergoes stimulus-coupled conformational reorganization to regulate metabolism in miceNat Commun. 2021 Jun 9;12(1):3493. doi: 10.1038/s41467-021-23595-x.
    94. Ritter MJ, Amano I, Imai N, Soares De Oliveira L, Vella KR, Hollenberg ANNuclear Receptor CoRepressors, NCOR1 and SMRT, are required for maintaining systemic metabolic homeostasisMol Metab. 2021 Nov;53:101315. doi: 10.1016/j.molmet.2021.101315.
    95. Shimada M, Hirashima N, Iwase H, Saito M, Kondo H, Urata N, Unita S, Kondo T, Tanaka D, Tsunekawa T, Nakamura S, Nishikura M, Miyazawa K, Fukuhara K, Fujishiro M.Evaluating patient acceptability and bowel preparation efficacy of sodium picosulfate-magnesium citrate for colonoscopyDEN Open. 2021 Sep 28;2(1):e59. doi: 10.1002/deo2.59. eCollection 2022 Apr.
  • 2020年
    1. Niikura R, Nagata N, Yamada A, Honda T, Hasatani K, Ishii N, Shiratori Y, Doyama H, Nishida T, Sumiyoshi T, Fujita T, Kiyotoki S, Yada T, Yamamoto K, Shinozaki T, Takata M, Mikami T, Mabe K, Hara K, Fujishiro M, Koike K. Efficacy and Safety of Early vs Elective Colonoscopy for Acute Lower Gastrointestinal Bleeding Gastroenterology 10.1053/j.gastro.2019.09.010
    2. Yoshioka N, Ishigami M, Watanabe Y, Sumi H, Doisaki M, Yamaguchi T, Ito T, Ishizu Y, Kuzuya T, Honda T, Ishikawa T, Haruta JI, Fujishiro M. Effect of weight change and lifestyle modifications on the development or remission of nonalcoholic fatty liver disease: sex-specific analysis Sci Rep 10.1038/s41598-019-57369-9
    3. Taylor RS, Taylor RJ, Bayliss S, Hagström H, Nasr P, Schattenberg JM, Ishigami M, Toyoda H, Wai-Sun Wong V, Peleg N, Shlomai A, Sebastiani G, Seko Y, Bhala N, Younossi ZM, Anstee QM, McPherson S, Newsome PN. Association Between Fibrosis Stage and Outcomes of Patients With Nonalcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis Gastroenterology 10.1053/j.gastro.2020.01.043
    4. Ohno E, Hirooka Y, Kawashima H, Ishikawa T, Fujishiro M. Endoscopic ultrasonography for the evaluation of pancreatic cystic neoplasms J Med Ultrason (2001) 10.1007/s10396-019-00980-0
    5. Yamada K, Kawashima H, Ohno E, Ishikawa T, Tanaka H, Nakamura M, Miyahara R, Ishigami M, Hirooka Y, Fujishiro M. Diagnosis of vascular invasion in pancreatic ductal adenocarcinoma using endoscopic ultrasound elastography BMC Gastroenterol 10.1186/s12876-020-01228-9
    6. Furukawa K, Miyahara R, Funasaka K, Fujishiro M. Localized Gastric Amyloidosis J Gastrointestin Liver Dis 10.15403/jgld-3088
    7. Sasaki Y, Ishikawa T, Kawashima H, Ohno E, Shimoyama Y, Ishikawa E, Fujishiro M. Gender difference in the transabdominal ultrasound findings of solid-pseudopapillary neoplasm Pancreatology 10.1016/j.pan.2020.06.016
    8. Hosono I, Miyahara R, Furukawa K, Funasaka K, Sawada T, Maeda K, Yamamura T, Ishikawa T, Ohno E, Nakamura M, Kawashima H, Yokoi T, Tsukamoto T, Hirooka Y, Fujishiro M. Use of Immunostaining for the diagnosis of Lymphovascular invasion in superficial Barrett's esophageal adenocarcinoma BMC Gastroenterol 10.1186/s12876-020-01319-7
    9. Suzuki H, Kawashima H, Ohno E, Ishikawa T, Hashimoto S, Nakamura M, Miyahara R, Ishigami M, Hirooka Y, Fujishiro M. What is the role of measuring shear wave dispersion using shear wave elastography in pancreatic parenchyma? J Med Ultrason (2001) 10.1007/s10396-020-01033-7
    10. Nishio R, Kawashima H, Nakamura M, Ohno E, Ishikawa T, Yamamura T, Maeda K, Sawada T, Tanaka H, Sakai D, Miyahara R, Ishigami M, Hirooka Y, Fujishiro M. Double-balloon endoscopic retrograde cholangiopancreatography for patients who underwent liver operation: A retrospective study World J Gastroenterol 10.3748/wjg.v26.i10.1056
    11. Fujishiro M, Furukawa K, Yamamura T, Nakamura M, Honda T, Maeda O, Ishigami M, Kawashima H. Nonexposed wall-inversion surgery as a novel local resection method for neoplasms in the gastrointestinal tract Nagoya J Med Sci 10.18999/nagjms.82.2.175
    12. Zorron Cheng Tao Pu L, Chiam KH, Yamamura T, Nakamura M, Berzin TM, Mir FF, Hourneaux de Moura EG, Madruga Neto AC, Koay DSC, Loong CK, Ovenden A, Edwards S, Burt AD, Hirooka Y, Fujishiro M, Singh R. Narrow-band imaging for scar (NBI-SCAR) classification: from conception to multicenter validation Gastrointest Endosc 10.1016/j.gie.2019.08.036
    13. Furukawa K, Nakamura M, Fujishiro M. [Endoscopic screening for gastric cancer] Nihon Shokakibyo Gakkai Zasshi 10.11405/nisshoshi.117.469
    14. Murate K, Maeda K, Nakamura M, Sugiyama D, Wada H, Yamamura T, Sawada T, Mizutani Y, Ishikawa T, Furukawa K, Ohno E, Honda T, Kawashima H, Miyahara R, Ishigami M, Nishikawa H, Fujishiro M. Endoscopic Activity and Serum TNF-α Level at Baseline Are Associated With Clinical Response to Ustekinumab in Crohn's Disease Patients Inflamm Bowel Dis 10.1093/ibd/izaa086
    15. Niwa Y, Nakamura M, Kawashima H, Yamamura T, Maeda K, Sawada T, Mizutani Y, Ishikawa E, Ishikawa T, Kakushima N, Furukawa K, Ohno E, Honda T, Ishigami M, Fujishiro M. Accuracy of carbon dioxide insufflation for endoscopic retrograde cholangiopancreatography using double-balloon endoscopy World J Gastroenterol 10.3748/wjg.v26.i42.6669
    16. Kataoka Y, Tsuji Y, Hirasawa K, Takimoto K, Wada T, Mochizuki S, Ohata K, Sakaguchi Y, Niimi K, Ono S, Kodashima S, Yamamichi N, Fujishiro M, Koike K. Reply to Murakami et al Endoscopy 10.1055/a-1026-6136
    17. Yamamoto K, Kuzuya T, Honda T, Ito T, Ishizu Y, Nakamura M, Miyahara R, Kawashima H, Ishigami M, Fujishiro M. Relationship Between Adverse Events and Microbiomes in Advanced Hepatocellular Carcinoma Patients Treated With Sorafenib Anticancer Res 10.21873/anticanres.13996
    18. Saito H, Tanimoto T, Ozawa T, Ishihara S, Fujishiro M, Shichijo S, Hirasawa D, Matsuda T, Endo Y, Tada T. Automatic anatomical classification of colonoscopic images using deep convolutional neural networks Gastroenterol Rep (Oxf) 10.1093/gastro/goaa078
    19. Hattori S, Nakamura M, Yamamura T, Maeda K, Sawada T, Mizutani Y, Yamamoto K, Ishikawa T, Furukawa K, Ohno E, Honda T, Kawashima H, Ishigami M, Hirooka Y, Fujishiro M. The microbiome can predict mucosal healing in small intestine in patients with Crohn's disease J Gastroenterol 10.1007/s00535-020-01728-1
    20. Ishikawa T, Kawashima H, Ohno E, Iida T, Suzuki H, Uetsuki K, Yamada K, Yashika J, Yoshikawa M, Gibo N, Aoki T, Kataoka K, Mori H, Fujishiro M. Risks and characteristics of pancreatic cancer and pancreatic relapse in autoimmune pancreatitis patients J Gastroenterol Hepatol 10.1111/jgh.15163
    21. Ozawa T, Ishihara S, Fujishiro M, Kumagai Y, Shichijo S, Tada T. Automated endoscopic detection and classification of colorectal polyps using convolutional neural networks Therap Adv Gastroenterol 10.1177/1756284820910659
    22. Tanaka T, Kuzuya T, Ishigami M, Ito T, Ishizu Y, Honda T, Ishikawa T, Fujishiro M. Efficacy and Safety of Sorafenib in Unresectable Hepatocellular Carcinoma with Bile Duct Invasion Oncology 10.1159/000507051
    23. Zorron Cheng Tao Pu L, Maicas G, Tian Y, Yamamura T, Nakamura M, Suzuki H, Singh G, Rana K, Hirooka Y, Burt AD, Fujishiro M, Carneiro G, Singh R. Computer-aided diagnosis for characterization of colorectal lesions: comprehensive software that includes differentiation of serrated lesions Gastrointest Endosc 10.1016/j.gie.2020.02.042
    24. Zorron Cheng Tao Pu L, Yamamura T, Nakamura M, Koay DSC, Ovenden A, Edwards S, Burt AD, Hirooka Y, Fujishiro M, Singh R. Comparison of different virtual chromoendoscopy classification systems for the characterization of colorectal lesions JGH Open 10.1002/jgh3.12382
    25. Suzuki H, Nakamura M, Yamamura T, Maeda K, Sawada T, Mizutani Y, Ishikawa T, Furukawa K, Ohno E, Honda T, Kawashima H, Ishigami M, Fujishiro M. A Prospective Study of Factors Associated with Abdominal Pain in Patients during Unsedated Colonoscopy Using a Magnifying Endoscope Intern Med 10.2169/internalmedicine.4267-19
    26. Zorron Cheng Tao Pu L, Rana K, Singh G, Nakamura M, Yamamura T, Koay DSC, Ovenden A, Edwards S, Ruszkiewicz A, Hirooka Y, Fujishiro M, Burt AD, Singh R. Different factors are associated with conventional adenoma and serrated colorectal neoplasia Nagoya J Med Sci 10.18999/nagjms.82.2.335
    27. Sakamaki K, Funasaka K, Miyahara R, Furukawa K, Yamamura T, Ohno E, Nakamura M, Kawashima H, Hirooka Y, Fujishiro M, Goto H. Low ETV1 mRNA expression is associated with recurrence in gastrointestinal stromal tumors Sci Rep 10.1038/s41598-020-71719-y
    28. Ishimaru T, Kawashima H, Tainaka T, Suzuki K, Takami S, Kakihara T, Katoh R, Aoyama T, Uchida H, Iwanaka T. Laparoscopically Assisted Anorectoplasty for Intermediate-Type Imperforate Anus: Comparison of Surgical Outcomes with the Sacroperineal Approach J Laparoendosc Adv Surg Tech A 10.1089/lap.2018.0330
    29. Ohno E, Kawashima H, Ishikawa T, Iida T, Suzuki H, Uetsuki K, Yashika J, Yamada K, Yoshikawa M, Gibo N, Aoki T, Kataoka K, Mori H, Hirooka Y, Fujishiro M. Can contrast-enhanced harmonic endoscopic ultrasonography accurately diagnose main pancreatic duct involvement in intraductal papillary mucinous neoplasms? Pancreatology 10.1016/j.pan.2020.06.004
    30. Matsui K, Funasaka K, Miyahara R, Furukawa K, Matsushita M, Yamamura T, Ishikawa T, Ohno E, Nakamura M, Kawashima H, Watanabe O, Ohara K, Hirooka Y, Goto H. Generation of magnifying endoscopic images of gastric neoplasms based on an all-in-focus algorithm J Gastroenterol Hepatol 10.1111/jgh.14792
    31. Yamada K, Nakamura M, Yamamura T, Maeda K, Sawada T, Mizutani Y, Ishikawa T, Furukawa K, Ohno E, Miyahara R, Kawashima H, Hotta N, Hirooka Y. Clinical Factors Associated with Missing Colorectal Polyp on Colon Capsule Endoscopy Digestion 10.1159/000498942
    32. Ito T, Ishigami M, Morooka H, Yamamoto K, Imai N, Ishizu Y, Honda T, Nishimura D, Tada T, Yasuda S, Toyoda H, Kumada T, Fujishiro M. The albumin-bilirubin score as a predictor of outcomes in Japanese patients with PBC: an analysis using time-dependent ROC Sci Rep 10.1038/s41598-020-74732-3
    33. Emura F, Sharma P, Arantes V, Cerisoli C, Parra-Blanco A, Sumiyama K, Araya R, Sobrino S, Chiu P, Matsuda K, Gonzalez R, Fujishiro M, Tajiri H. Principles and practice to facilitate complete photodocumentation of the upper gastrointestinal tract: World Endoscopy Organization position statement Dig Endosc 10.1111/den.13530
    34. Zorron Cheng Tao Pu L, Yamamura T, Nakamura M, Esaki M, Kaosombatwattana U, Rodriguez MR, Edwards S, Burt AD, Singh R, Hirooka Y, Fujishiro M. Learning curve for mastery of colorectal endoscopic submucosal dissection: Perspectives from a large Japanese cohort JGH Open 10.1002/jgh3.12298
    35. Nomura A, Ishigami M, Honda T, Kuzuya T, Ishizu Y, Ito T, Kamei H, Onishi Y, Ogura Y, Fujishiro M. Limitation of non-transplant treatment and proper timing for liver transplantation in patients with hepatocellular carcinoma considering long-term survival Medicine (Baltimore) 10.1097/MD.0000000000021161
    36. Ishikawa E, Nakamura M, Shimada K, Tanaka T, Satou A, Kohno K, Sakakibara A, Furukawa K, Yamamura T, Miyahara R, Nakamura S, Kato S, Fujishiro M. Prognostic impact of PD-L1 expression in primary gastric and intestinal diffuse large B-cell lymphoma J Gastroenterol 10.1007/s00535-019-01616-3
    37. Ishikawa T, Kawashima H, Ohno E, Suhara H, Hayashi D, Hiramatsu T, Matsubara H, Suzuki T, Kuwahara T, Ishikawa E, Shimoyama Y, Kinoshita F, Hirooka Y, Fujishiro M. Usefulness of endoscopic ultrasound-guided fine-needle biopsy for the diagnosis of autoimmune pancreatitis using a 22-gauge Franseen needle: a prospective multicenter study Endoscopy 10.1055/a-1183-3583
    38. Hosokawa T, Hosokawa M, Tanami Y, Sato Y, Ishimaru T, Tanaka Y, Kawashima H, Oguma E. Use of ultrasound findings to predict bowel ischemic changes in pediatric patients with intestinal volvulus J Ultrasound Med 10.1002/jum.15145
    39. Ogiso S, Kamei H, Onishi Y, Kurata N, Jobara K, Kawashima H, Ogura Y. Decreased long-term graft survival in persistent biliary complications after right-lobe living-donor liver transplantation Clin Transplant 10.1111/ctr.13771
    40. Ishizu Y, Ishigami M, Hayashi K, Honda T, Kuzuya T, Ito T, Fujishiro M. Rapid increase of platelet counts during antiviral therapy in patients with hepatitis C virus infection Hepatol Res 10.1111/hepr.13426
    41. Zorron Cheng Tao Pu L, Yamamoto K, Honda T, Nakamura M, Yamamura T, Hattori S, Burt AD, Singh R, Hirooka Y, Fujishiro M. Microbiota profile is different for early and invasive colorectal cancer and is consistent throughout the colon J Gastroenterol Hepatol 10.1111/jgh.14868
    42. Kuzuya T, Ishigami M, Ito T, Ishizu Y, Honda T, Ishikawa T, Fujishiro M. Initial Experience of Ramucirumab Treatment After Lenvatinib Failure for Patients With Advanced Hepatocellular Carcinoma Anticancer Res 10.21873/anticanres.14167
    43. Zorron Cheng Tao Pu L, Singh G, Rana K, Nakamura M, Yamamura T, Krishnamurthi S, Ovenden A, Edwards S, Ruszkiewicz A, Hirooka Y, Fujishiro M, Burt AD, Singh R. Polyp Detection Rate as a Surrogate for Adenoma and Sessile Serrated Adenoma/Polyp Detection Rates Gastrointest Tumors 10.1159/000505622
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    46. Aoki T, Yamada A, Kato Y, Saito H, Tsuboi A, Nakada A, Niikura R, Fujishiro M, Oka S, Ishihara S, Matsuda T, Nakahori M, Tanaka S, Koike K, Tada T. Automatic detection of blood content in capsule endoscopy images based on a deep convolutional neural network J Gastroenterol Hepatol 10.1111/jgh.14941
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    57. Hosokawa T, Takahashi H, Tanami Y, Sato Y, Ishimaru T, Tanaka Y, Kawashima H, Oguma E, Yamada Y. Diagnostic Accuracy of Ultrasound for the Directionality of Testicular Rotation and the Degree of Spermatic Cord Twist in Pediatric Patients With Testicular Torsion J Ultrasound Med 10.1002/jum.15084
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