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発育・加齢医学小児科学/成長発達医学

概要

わが国では現在少子化が急速に進行しているが、核家族化や医療の高度化に伴い、小児科医のニーズはむしろ増大している。当教室では、幅広い小児疾患に対しよりよい医療を提供すべく、診療・研究・教育に努めている。
わが国の現状では、小児科医はまずgeneralistとして一人一人が幅広い小児科疾患に対応する必要がある一方で、specialistとして高度な専門性を持つことが望まれる。当教室では、主に5つの診療グループがあり、specialistとしての専門医療を行っている。
また、40に及ぶ関連病院と連携して、common diseaseに対しEBMに基づいた共同研究を遂行している。研究面では、臨床に直結したテーマを主体に幅広い分野で業績を築きあげてきた。これまで日本医療研究開発機構による難治性疾患実用化研究事業等に採択され、細胞療法・遺伝子治療を視野に入れた、先端医療にも着手している。

研究プロジェクト

  • 小児期造血障害の病院解明および治療法の開発
  • 造血幹細胞移植における合併症の予防および治療法の開発
  • 小児悪性腫瘍に対する病態解明および治療法の開発
  • 小児期発症てんかんの臨床的検討
  • 新生児脳障害の発生機序の解明
  • ウィルス疾患の遺伝子診断
  • ウィルスの中枢神経系感染機構の解明
  • 先天性免疫不全症の病態解明および治療法の開発
  • 早産児の中枢神経発達に関する研究
  • 不整脈の臨床的検討

教員

構成員名役職所属
髙橋 義行 教授 小児科学/血液
夏目 淳 教授 障害児(者)医療学寄付講座/神経
伊藤 嘉規 准教授 小児科学/ウイルス
加藤 太一 准教授 成長発達医学/循環器
濱 麻人 准教授 小児科学/血液
川田 潤一 講師 小児科学/ウイルス
奥野 友介 特任講師 先端医療・臨床研究支援センター/血液
城所 博之 助教 小児科学/神経
村松 秀城 助教 小児科学/血液
中田 智彦 助教 小児科学/神経
成田 敦 助教 小児がん治療センター/血液
西尾 信博 特任助教 先端医療・臨床研究支援センター/血液
深澤 佳絵 病院助教 小児科学/循環器
大野 敦子 病院助教 小児集中治療学/神経
川島 希 病院助教 小児科学/血液

研究実績

  • 2016年
    1. Ogawa C, Natsume J, Yamamoto H, et al. Autopsy findings of a patient with acute encephalitis and refractory, repetitive partial seizures. Seizure 2016;35:80-2.
    2. Natsume J, Ogawa C, Fukasawa T, et al. White Matter Abnormality Correlates with Developmental and Seizure Outcomes in West Syndrome of Unknown Etiology. Am J Neuroradiol 2016;37:698-705.
    3. Kawada J, Okuno Y, Torii Y, et al. Identification of Viruses in Cases of Pediatric Acute Encephalitis and Encephalopathy Using Next-Generation Sequencing. Sci Rep 2016;6:33452.
    4. Kataoka S, Muramatsu H, Okuno Y, et al. Extrapulmonary tuberculosis mimicking Mendelian susceptibility to mycobacterial disease in a patient with signal transducer and activator of transcription 1 (STAT1) gain-of-function mutation. J Allergy Clin Immunol 2016;137:619-22 e1.
    5. Ando S, Kawada JI, Watanabe T, et al. Tofacitinib induces G1 cell-cycle arrest and inhibits tumor growth in Epstein-Barr virus-associated T and natural killer cell lymphoma cells. Oncotarget 2016;7:76793-805.
  • 2015年
    1. Yokoi S, Ishihara N, Miya F, et al. TUBA1A mutation can cause a hydranencephaly-like severe form of cortical dysgenesis. Sci Rep 2015;5:15165.
    2. Yamamoto H, Okumura A, Natsume J, Kojima S, Mizuguchi M. A severity score for acute necrotizing encephalopathy. Brain Dev 2015;37:322-7.
    3. Yamamoto H, Natsume J, Kidokoro H, et al. Clinical and neuroimaging findings in children with posterior reversible encephalopathy syndrome. Eur J Paediatr Neurol 2015;19:672-8.
    4. Wang X, Muramatsu H, Okuno Y, et al. GATA2 and secondary mutations in familial myelodysplastic syndromes and pediatric myeloid malignancies. Haematologica 2015;100:e398-401.
    5. Suzuki M, Takeda T, Nakagawa H, et al. The heat shock protein 90 inhibitor BIIB021 suppresses the growth of T and natural killer cell lymphomas. Front Microbiol 2015;6:280.
    6. Sato Y, Oshiro M, Takemoto K, et al. Multicenter observational study comparing sedation/analgesia protocols for laser photocoagulation treatment of retinopathy of prematurity. J Perinatol 2015;35:965-9.
    7. Sakaguchi H, Muramatsu H, Okuno Y, et al. Aberrant DNA Methylation Is Associated with a Poor Outcome in Juvenile Myelomonocytic Leukemia. PLoS One 2015;10:e0145394.
    8. Okuno Y, Hoshino A, Muramatsu H, et al. Late-Onset Combined Immunodeficiency with a Novel IL2RG Mutation and Probable Revertant Somatic Mosaicism. J Clin Immunol 2015;35:610-4.
    9. Nishio N, Dotti G. Oncolytic virus expressing RANTES and IL-15 enhances function of CAR-modified T cells in solid tumors. Oncoimmunology 2015;4:e988098.
    10. Narita A, Muramatsu H, Sekiya Y, et al. Paroxysmal nocturnal hemoglobinuria and telomere length predicts response to immunosuppressive therapy in pediatric aplastic anemia. Haematologica 2015;100:1546-52.
    11. Kishimoto Y, Kato T, Ito M, et al. Hydrogen ameliorates pulmonary hypertension in rats by anti-inflammatory and antioxidant effects. J Thorac Cardiovasc Surg 2015;150:645-54 e3.
    12. Kawashima N, Narita A, Wang X, et al. Aldehyde dehydrogenase-2 polymorphism contributes to the progression of bone marrow failure in children with idiopathic aplastic anaemia. Br J Haematol 2015;168:460-3.
    13. Kawashima N, Muramatsu H, Okuno Y, et al. Fulminant adenovirus hepatitis after hematopoietic stem cell transplant: Retrospective real-time PCR analysis for adenovirus DNA in two cases. J Infect Chemother 2015;21:857-63.
    14. Kawashima N, Ito Y, Sekiya Y, et al. Choreito formula for BK virus-associated hemorrhagic cystitis after allogeneic hematopoietic stem cell transplantation. Biol Blood Marrow Transplant 2015;21:319-25.
    15. Kawano Y, Suzuki M, Kawada J, et al. Effectiveness and safety of immunization with live-attenuated and inactivated vaccines for pediatric liver transplantation recipients. Vaccine 2015;33:1440-5.
    16. Kawada J, Torii Y, Kawano Y, et al. Viral load in children with congenital cytomegalovirus infection identified on newborn hearing screening. J Clin Virol 2015;65:41-5.
    17. Kamiya Y, Kawada J, Kawano Y, et al. Serum microRNAs as Potential Biomarkers of Juvenile Idiopathic Arthritis. Clin Rheumatol 2015;34:1705-12.
    18. Ito Y, Takahashi S, Kagitani-Shimono K, et al. Nationwide survey of glucose transporter-1 deficiency syndrome (GLUT-1DS) in Japan. Brain Dev 2015;37:780-9.
    19. Ito Y, Natsume J, Kidokoro H, et al. Seizure characteristics of epilepsy in childhood after acute encephalopathy with biphasic seizures and late reduced diffusion. Epilepsia 2015;56:1286-93.
    20. Hayakawa M, Taguchi T, Urushihara N, et al. Outcome in VLBW infants with surgical intestinal disorder at 18 months of corrected age. Pediatr Int 2015;57:633-8.
    21. Hattori T, Sato Y, Kondo T, et al. Administration of umbilical cord blood cells transiently decreased hypoxic-ischemic brain injury in neonatal rats. Dev Neurosci 2015;37:95-104.
    22. Hama A, Takahashi Y, Muramatsu H, et al. Comparison of long-term outcomes between children with aplastic anemia and refractory cytopenia of childhood who received immunosuppressive therapy with antithymocyte globulin and cyclosporine. Haematologica 2015;100:1426-33.
    23. Azuma Y, Nakata T, Tanaka M, et al. Congenital myasthenic syndrome in Japan: ethnically unique mutations in muscle nicotinic acetylcholine receptor subunits. Neuromuscul Disord 2015;25:60-9.
  • 2014年
    1. Suzuki M, Ito Y, Shimada A, et al. Long-term parvovirus B19 infections with genetic drift after cord blood transplantation complicated by persistent CD4+ lymphocytopenia. J Pediatr Hematol Oncol 2014;36:e65-8.
    2. Sakaguchi H, Nishio N, Hama A, et al. Peripheral blood lymphocyte telomere length as a predictor of response to immunosuppressive therapy in childhood aplastic anemia. Haematologica 2014;99:1312-6.
    3. Nishio N, Diaconu I, Liu H, et al. Armed oncolytic virus enhances immune functions of chimeric antigen receptor-modified T cells in solid tumors. Cancer Res 2014;74:5195-205.
    4. Natsume J, Maeda N, Itomi K, et al. PET in infancy predicts long-term outcome during adolescence in cryptogenic West syndrome. Am J Neuroradiol 2014;35:1580-5.
    5. Muramatsu H, Sakaguchi H, Taga T, et al. Reduced intensity conditioning in allogeneic stem cell transplantation for AML with Down syndrome. Pediatr Blood Cancer 2014;61:925-7.
    6. Kojima S, Cucuianu A, Takahashi Y, et al. Dose intensity and autologous stem cell transplantation as salvage therapy for pediatric primary CNS malignancies. Int J Nanomedicine 2014;9:3247-8.
    7. Kawano Y, Kawada J, Ito Y. Epstein-Barr virus microRNAs in plasma as potential biomarkers for chronic infections: reply to Makarewicz et al. J Infect Dis 2014;209:1298-300.
    8. Kawada J, Ito Y, Iwata S, et al. mTOR inhibitors induce cell-cycle arrest and inhibit tumor growth in Epstein-Barr virus-associated T and natural killer cell lymphoma cells. Clin Cancer Res 2014;20:5412-22.
    9. Ito M, Kidokoro H, Sugiyama Y, et al. Paradoxical downward seizure pattern on amplitude-integrated electroencephalogram. J Perinatol 2014;34:642-4.
    10. Ismael O, Shimada A, Elmahdi S, et al. RUNX1 mutation associated with clonal evolution in relapsed pediatric acute myeloid leukemia with t(16;21)(p11;q22). Int J Hematol 2014;99:169-74.
    11. Hayano S, Fukumi D, Murayama H, Baba R. Successful arterial switch operation for transposition of the great arteries with intact ventricular septum and congenital diaphragmatic hernia: A case report. Journal of Cardiology Cases 2014;10:39-41.
    12. Hayakawa M, Ito Y, Saito S, et al. Incidence and prediction of outcome in hypoxic-ischemic encephalopathy in Japan. Pediatr Int 2014;56:215-21.

研究キーワード

小児期造血障害、造血幹細胞移植、小児期発症てんかん、新生児脳障害、ウィルス遺伝子診断、中枢神経系感染症、先天性免疫不全症、小児不整脈