研究室紹介

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脳神経病態制御学精神医学

概要

患者・家族のニーズを踏まえ、「日々の臨床疑問の解決」とともに、「病因・病態を解明し、病因・病態に即した診断、治療・予防法の開発」を目指すことが基本方針です。この目的の実現には、様々な臨床研究、基礎研究が双方向性に共同することが不可欠です。
当講座では、統合失調症、うつ病・双極性障害、認知症、摂食障害、自閉スペクトラム症、認知症などの多様な精神障害の診断・治療法や病因・病態を、bio-psycho-social（生物・心理・社会的）な観点から研究しています。

臨床研究

現在利用可能な精神医学的診断・評価法や薬物・心理社会的治療法を、生物・心理・社会的側面から再検討して、特性を明確化し、最適の診断・治療を患者さんに提供することを目標にしています。

対象疾患：統合失調症、うつ病・双極性障害、自閉スペクトラム症、摂食障害、不安症、身体症状症、認知症

疫学研究

精神障害の発症頻度と発症に関与する生物・心理・社会的因子を特定することによって、以下の臨床的活用を目指します。

ある集団の診断において「どの疾患の可能性が高いか」
二次予防（早期発見による早期治療）の際に高リスク群を同定
一次予防（発症予防）のため、発症危険因子を同定
実施している具体例
- 周産期メンタルヘルス：心理社会的要因を加味した妊産婦の気分変動に関するゲノムコホート研究ならびにその児の発達に関するコホート研究
- 産業衛生：職域のうつ病の疫学的研究と早期発見の手法開発・介入研究
- 歯科口腔外科患者・がん患者・移植患者・心不全患者に生じるうつ病・不安症の疫学や治療法の研究
- 摂食障害の疫学：摂食障害の有病率や、発症に関わる心理社会的因子、さらに自閉スペクトラム症との関係を明らかにするための疫学研究
- せん妄などの精神病理/精神薬理学的疫学研究

病因・病態解明研究

精神障害の克服に向けて、臨床研究および基礎研究の間で連携を図り、各領域において得られた研究成果を双方向的に照合することで、病因・病態に基づく心理社会的介入法、根本的治療法、予防法の開発と、その臨床試験の実施を目指しています。
具体的にはオミックス解析、ゲノム解析、ゲノム解析結果に基づく遺伝子改変モデル動物の解析、患者由来iPS細胞から樹立したモデル細胞の解析、神経画像（MRI、 NIRS）解析、死後脳解析、を実施しています。

対象疾患：統合失調症、うつ病・双極性障害、摂食障害、自閉スペクトラム症、認知症

研究プロジェクト

1. がん患者や移植患者の精神医学的側面に関する検討

がん患者や臓器移植患者は，うつ病，不安症，せん妄などの精神医学的疾患の合併率が高い点を考慮し，頭頸部がんのため拡大手術を受ける患者，血液がんのため造血幹細胞移植を受ける患者，肝移植・腎移植のドナーおよびレシピエント，補助人工心臓の植込術や心移植を施行する患者を対象に，抑うつ・不安に関連する因子を含む様々な心理社会的因子について検討することで，これらの患者の精神医学的疾患合併の早期発見・早期介入を目指しています。

研究具体例1.jpg

2. 歯科領域の疼痛性疾患の生物心理社会的研究

歯科領域の疼痛を訴え、情動、認知が強く影響されていると判断される患者を対象に前向きコホート研究を行っています。構造化面接（SCID）により診断し、治療前後に疼痛および抑うつの評価を行い、人格傾向・ソーシャルサポート・養育体験を含む心理検査、温冷刺激による疼痛閾値評価および血液を取得し、疼痛刺激応答機構の破綻により誘発されるストレス関連疾患の病態解明から、より良い治療法・診断法の開発を目指しています。

3. 脳の個人特性を踏まえた運転技能の理解

自動車の運転は、我が国で社会生活を実施する上で重要な要素です。しかし、運転技能に関わる脳機能は明確化されず、精神障害（うつ病、認知症など）患者、向精神薬服用時には、添付文書の記載等により自動車運転が規制されています。そこで、精神障害、向精神薬、加齢が引きおこす運転技能・認知機能の変化を明確化し、添付文書の記載内容の適正化、職場復帰の支援・予測・交通事故防止、認知リハビリテーションの開発、さらに精神疾患患者・高齢者に優しい自動車開発への証左を得ることを目指しています。

4. 神経性やせ症の神経回路病態解明

神経性やせ症は，死亡率も高く，慢性化する場合も多い，重篤な精神疾患です．しかし，その病態は不明で，有効な治療法もないのが現状です．神経性やせ症の特徴として，自己の身体像イメージが極端になっていること, 症状の背景には摂食に関連する脳や身体臓器に関わる分子や遺伝因子が関与していることがあげられます．これらに着目して，人格傾向や養育体験などの心理社会的因子とともに，神経画像（MRI，NIRS）解析，ゲノム解析，神経心理学的指標の測定, 生理活性物質の測定，体組成と臨床指標の関連解析，腸内細菌叢の解析などを通して神経回路病態を解明し，より良い治療法の開発を目指しています。

摂食障害研究.jpg

5. 妊産婦とその児を対象とした前向きゲノムコホート研究

うつ病のなりやすさには男女差があり、女性は男性の２倍、うつ病になりやすいといわれています。とりわけ妊娠中や出産後は、一生の中でもうつ病になりやすい時期です。妊産婦がうつ病になると、妊産婦のこころの健康に加え、日々の生活や育児にも影響が及びます。我々は、従来の研究手法に加えて、エピゲノムの解析やAI解析などの手法もとり入れ、前向きゲノムコホート研究を行うことで、遺伝要因と環境要因の両方を検討し、これらの要因と妊産婦のうつ病との関係を明らかにすることを目指しています。

6. オミックスによる統合失調症、双極性障害、自閉スペクトラム症の診断法開発を目指した研究

統合失調症や双極性障害は発症後、数年で病勢が進行すると考えられていますが、診断に有用な検査法がないため治療的介入が遅れ、その結果、難治化している症例が少なくないのが現状です。また、自閉スペクトラム症は的確な診断と評価がなされず、利用可能な治療・療育が適切に為されていない場合が多く、さらに、現在の治療・療育の効果にも限界があります。そこで、統合失調症・双極性障害・自閉スペクトラム症の病因・病態を特徴づける分子を、オミックス（網羅的ゲノム解析と網羅的発現解析）によって同定し、分子レベルから診断体系を組み替え、早期かつ的確な診断検査法の開発に繋げることを目指しています。

7. 精神障害克服を目指すゲノム解析を起点とした基礎・臨床連携研究

統合失調症・双極性障害・自閉スペクトラム症は、いずれも長期の治療・療育が必要で、現在、十分な効果をあげることが出来ていない精神障害です。したがって、その病因・病態を解明して、根本的治療法、予防法を開発することが求められています。我々は、ゲノム科学、神経科学、情報科学の手法により、1) 患者ゲノムの解析、2) 1の結果に基づく遺伝子改変モデル動物の解析、1の結果に基づく遺伝子変異を有する患者由来iPS細胞から樹立したモデル中枢神経系細胞の解析、などを実施しています。これらの知見を統合し、基礎研究と臨床研究の連携により、精神障害の克服を目指した研究を実施しています。

8. ヒト脳組織研究ー臨床診断の精度の向上へむけて

精神障害の臨床的な診断は、臨床症状とMRIなどの神経画像情報や、認知機能検査等の心理検査などを総合して行っています。しかし特に認知症では、現在でも診断を確定するには、脳の病理組織の観察が必須です。したがって、臨床診断の正確さを高めるためには、ヒト脳組織を対象とした神経病理診断の蓄積し、二つの情報を照らし合わせ、統合することが求められます。さらに、統合失調症・気分障害などの精神障害も脳に病態があることは確かであり、病態解明にヒト脳組織の検討は欠かせません。以上の観点から、ヒト脳組織解析による検討を実施しています。

9. 精神疾患横断的な脳画像・視線解析を用いた検討

脳画像研究：主にMRIを用いて、精神疾患の病態解明や、診断補助・治療の効果判定・予後の予測などを目標とし研究を行っています。また、脳の構造や機能と認知機能、眼球運動などの臨床データとの関連も検討しています。視線解析研究：アイトラッカーを利用し、移動する点や画像を見ているとき、作業をしているときの視線を記録し、精神疾患の中でも特徴的な視線移動を示す症例の研究を行っています。脳画像研究をはじめとする当科の様々な研究と連携して進めています。

脳画像・視線解析研究.png

10. 精神疾患横断的な睡眠ポリグラフ検査等を用いた検討

睡眠の障害は、様々な疾患を引き起こすことが知られています。睡眠の変化はその他の臨床症状に先行することが多く、その悪化や改善はうつ病の治療経過を見るうえで臨床的に有用な指標と考えられています。簡便で負担なく、自宅でも検査可能な睡眠モニターについて睡眠ポリグラフと比較検討しています。高齢になって精神症状を呈した患者さんを対象に、レム睡眠行動障害あるいは睡眠ポリグラフ検査上の必須所見であるREM sleep without atoniaに注目することで、レビー小体病の鑑別診断の可能性について検討を行っています。

睡眠研究.png

教員

構成員名	役職	所属
池田匡志	教授	大学院医学系研究科総合医学専攻
尾崎紀夫	特任教授	大学院医学系研究科精神疾患病態解明学糖鎖生命コア研究所細胞・個体制御部門
稲田俊也	特任教授	大学院医学系研究科精神医療学寄附講座
木村宏之	准教授	大学院医学系研究科総合医学専攻
髙橋　長秀	准教授	医学部附属病院親と子どもの心療科
岩本邦弘	准教授	大学院医学系研究科総合医学専攻
藤城　弘樹	特任准教授	大学院医学系研究科精神医療学寄附講座
Branko Aleksic	特任准教授	大学院医学系研究科名古屋大学・アデレード大学国際連携総合医学専攻
久島周	病院講師	医学部附属病院ゲノム医療センター
木村　大樹	講師	大学院医学系研究科総合医学専攻
鳥井洋太	講師	医学部附属病院精神科
山本真江里	講師	医学部附属病院精神科
小笠原　一能	病院助教	医学部附属病院卒後臨床研修・キャリア形成支援センター
立花　昌子	病院助教	医学部附属病院精神科
加藤　秀和	助教	医学部附属病院親と子どもの心療科
名和　佳弘	特任助教	大学院医学系研究科障害児（者）医療学寄附講座
岩田邦幸	病院助教	医学部附属病院精神科
荒深周生	病院助教	医学部附属病院化学療法部
森大輔	特任准教授	脳とこころの研究センター研究開発部門
有岡祐子	特任講師	医学部附属病院先端医療・臨床研究支援センター
宮田聖子	特任講師	大学院医学系研究科精神医療学寄附講座
奥村啓樹	特任助教	大学院医学系研究科

研究実績

2022年
1. Arafuka S, Fujishiro H, Iritani S, Torii Y, Miwa A, Yabata H, Sekiguchi H, Habuchi C, Kawashima K, Yoshida M, Iwasaki Y, Ozaki N. Striatal i-123-2 beta-carbomethoxy-3b-(4-iodophenyl)-n-(3-fluoropropyl)-nortropane single-photon emission computed tomography demonstrates nigral degeneration in the early stage of behavioural variant frontotemporal dementia: An autopsy case with frontotemporal lobar degeneration with trans-activation response DNA protein 43 type b. Psychogeriatrics. 2022;22(4):580-585.
2. Arafuka S, Sekiguchi H, Fujishiro H, Iritani S, Torii Y, Habuchi C, Yoshida M, Iwasaki Y, Ozaki N, Fujita K. Late-onset panic disorder as the initial presentation in autopsy-confirmed dementia with lewy bodies. Psychiatry and Clinical Neurosciences. 2023;77(4):242-244.
3. Fujishiro H, Arafuka S, Ogasawara K, Iwamoto K, Miyata S, Torii Y, Iritani S, Ozaki N. Temporal trajectories of proposed biomarkers in psychiatric-onset prodromal dementia with lewy bodies: A case report. Psychogeriatrics. 2023;23(1):196-200.
4. Furuta S, Aleksic B, Nawa Y, Kimura H, Kushima I, Ishizuka K, Kato H, Toyama M, Arioka Y, Mori D, Morikawa M, Inada T, Ozaki N. Investigation of olig2 as a candidate gene for schizophrenia and autism spectrum disorder. Nagoya Journal of Medical Science. 2022;84(2):260-268.
5. Hagikura M, Inada T. A case of schizophrenia with relapsed catatonia successfully treated with blonanserin transdermal patch. Neuropsychopharmacology Reports. 2023;43(1):150-153.
6. Ishizuka K, Tachibana M, Inada T. Possible Commonalities of Clinical Manifestations Between Dystonia and Catatonia. Front Psychiatry. 2022;13:876678.
7. Ito T, Yoshida M, Aida T, Kushima I, Hiramatsu Y, Ono M, Yoshimi A, Tanaka K, Ozaki N, Noda Y. Astrotactin 2 (astn2) regulates emotional and cognitive functions by affecting neuronal morphogenesis and monoaminergic systems. Journal of Neurochemistry. 2023;165(2):211-229.
8. Kaminogo K, Yamaguchi S, Tokura T, Kimura H, Kishi S, Yamamoto N, Ozaki N, Hibi H. Coping styles and quality of life in oral cancer patients undergoing radical resection and free flap reconstruction. Oral Oncology Reports. 2023;5:100015.
9. Kato S, Bagarinao E, Isoda H, Koyama S, Watanabe H, Maesawa S, Hara K, Katsuno M, Naganawa S, Ozaki N, Sobue G. Reproducibility of functional connectivity metrics estimated from resting-state functional mri with differences in days, coils, and global signal regression. Radiological Physics and Technology. 2022;15(4):298-310.
10. Kawabata K, Bagarinaob E, Watanabe H, Maesawab S, Mori D, Hara K, Ohdake R, Masuda M, Ogura A, Kato T, Koyama S, Katsuno M, Wakabayashi T, Kuzuya M, Hoshiyama M, Isoda H, Naganawa S, Ozaki N, Sobue G. Functional connector hubs in the cerebellum. Neuroimage. 2022;257:119263.
11. Kawai K, Iwamoto K, Miyata S, Okada I, Ando M, Fujishiro H, Noda A, Ozaki N. A Study of Factors Causing Sleep State Misperception in Patients with Depression. Nat Sci Sleep. 2022;14:1273-1283.
12. Kawakami I, Iga JI, Takahashi S, Lin Y-T, Fujishiro H. Towards an understanding of the pathological basis of senile depression and incident dementia: implications for treatment. Psychiatry Clin Neurosci 2022;76(12):620-632.
13. Kimura H, Nakatochi M, Aleksic B, Guevara J, Toyama M, Hayashi Y, Kato H, Kushima I, Morikawa M, Ishizuka K, Okada T, Tsurusaki Y, Fujita A, Miyake N, Ogi T, Takata A, Matsumoto N, Buxbaum J, Ozaki N, Sebat J. Exome sequencing analysis of japanese autism spectrum disorder case-control sample supports an increased burden of synaptic function-related genes. Translational Psychiatry. 2022;12(1):265.
14. Kimura H, Yokoyama H, Torii Y, Fujishiro H. Electroconvulsive therapy as a potential therapeutic option in psychiatric-onset prodromal dementia with Lewy bodies. Int J Geriatr Psychiatry 2023; 38(1):e5863.
15. Kubota C, Inada T, Lin SK, Avasthi A, Chee KY, Tanra AJ, Yang SY, Chen LY, Chong MY, Tripathi A, Kallivayalil RA, Grover S, Park SC, Kato TA, Xiang YT, Sim K, Maramis MM, Noor IM, Tan CH, Sartorius N, Shinfuku N. The factor structure of extrapyramidal symptoms evaluated using the drug-induced extrapyramidal symptoms scale in patients with schizophrenia: Results from the 2016 reap ap-4 study. Human Psychopharmacology-Clinical and Experimental. 2023;38(2):e2861.
16. Kushima I, Aleksic B, Kimura H, Nakatochi M, Lo T, Ikeda M, Arai M, Hashimoto R, Numata S, Okamura Y, Obara T, Inada T, Ozaki N. X chromosome aneuploidies and schizophrenia: Association analysis and phenotypic characterization. Psychiatry and Clinical Neurosciences. 2022;76(12):667-673.
17. Kushima I, Imaeda M, Tanaka S, Kato H, Oya-Ito T, Nakatochi M, Aleksic B, Ozaki N. Contribution of copy number variations to the risk of severe eating disorders. Psychiatry and Clinical Neurosciences. 2022;76(9):423-428.
18. Kushima I, Nakatochi M, Aleksic B, Okada T, Kimura H, Kato H, Morikawa M, Inada T, Ishizuka K, Torii Y, Nakamura Y, Tanaka S, Imaeda M, Takahashi N, Yamamoto M, Iwamoto K, Nawa Y, Ogawa N, Iritani S, Hayashi Y, Lo TY, Otgonbayar G, Furuta S, Iwata N, Ikeda M, Saito T, Ninomiya K, Okochi T, Hashimoto R, Yamamori H, Yasuda Y, Fujimoto M, Miura K, Itokawa M, Arai M, Miyashita M, Toriumi K, Ohi K, Shioiri T, Kitaichi K, Someya T, Watanabe Y, Egawa J, Takahashi T, Suzuki M, Sasaki T, Tochigi M, Nishimura F, Yamasue H, Kuwabara H, Wakuda T, Kato TA, Kanba S, Horikawa H, Usami M, Kodaira M, Watanabe K, Yoshikawa T, Toyota T, Yokoyama S, Munesue T, Kimura R, Funabiki Y, Kosaka H, Jung MY, Kasai K, Ikegame T, Jinde S, Numata S, Kinoshita M, Kato T, Kakiuchi C, Yamakawa K, Suzuki T, Hashimoto N, Ishikawa S, Yamagata B, Nio S, Murai T, Son S, Kunii Y, Yabe H, Inagaki M, Goto YI, Okumura Y, Ito T, Arioka Y, Mori D, Ozaki N. Cross-disorder analysis of genic and regulatory copy number variations in bipolar disorder, schizophrenia, and autism spectrum disorder. Biological Psychiatry. 2022;92(5):362-374.
19. Kushima I, Uematsu M, Ishizuka K, Aleksic B, Ozaki N. Psychiatric patients with a de novo 17q12 deletion: Two case reports. Psychiatry and Clinical Neurosciences. 2022;76(7):345-347.
20. Lo T, Kushima I, Aleksic B, Kato H, Nawa Y, Hayashi Y, Otgonbayar G, Kimura H, Arioka Y, Mori D, Ozaki N. Sequencing of selected chromatin remodelling genes reveals increased burden of rare missense variants in asd patients from the japanese population. International Review of Psychiatry. 2022;34(2):154-167.
21. Lo TY, Kushima I, Aleksic B, Yoshimi A, Someya T, Watanabe Y, Ozaki N. Clinical manifestations of schizophrenia in four patients with variants in voltage-gated calcium channel-encoding genes: A case series. Psychiatry and Clinical Neurosciences. 2023;77(1):57-59.
22. Miyake N, Tsurusaki Y, Fukai R, Kushima I, Okamoto N, Ohashi K, Nakamura K, Hashimoto R, Hiraki Y, Son S, Kato M, Sakai Y, Osaka H, Deguchi K, Matsuishi T, Takeshita S, Fattal-Valevski A, Ekhilevitch N, Tohyama J, Yap P, Keng WT, Kobayashi H, Takubo K, Okada T, Saitoh S, Yasuda Y, Murai T, Nakamura K, Ohga S, Matsumoto A, Inoue K, Saikusa T, Hershkovitz T, Kobayashi Y, Morikawa M, Ito A, Hara T, Uno Y, Seiwa C, Ishizuka K, Shirahata E, Fujita A, Koshimizu E, Miyatake S, Takata A, Mizuguchi T, Ozaki N, Matsumoto N. Molecular diagnosis of 405 individuals with autism spectrum disorder. European Journal of Human Genetics. 2023.
23. Miyata S, Otake H, Fujishiro H, Iwamo K, Noda A, Sone M, Ozaki N. Polysomnographic characteristics and predictors of positional obstructive sleep apnea in Japanese elderly. Sleep Biol. Rhythms. 2022;20:403-411.
24. Mizobuchi K, Kushima I, Kato H, Miyajima M, Kimura H, Ozaki N. Turner syndrome presenting with idiopathic regression: A case report. Psychiatry and Clinical Neurosciences. 2022;76(12):680-682.
25. Nawa Y, Kushima I, Aleksic B, Yamamoto M, Kimura H, Banno M, Hashimoto R, Ozaki N. Treatment-resistant schizophrenia in patients with 3q29 deletion: A case series of four patients. Psychiatry and Clinical Neurosciences. 2022;76(7):338-339.
26. Nishimura T, Takahashi N, Okumura A, Harada T, Iwabuchi T, Nakayasu C, Rahman MS, Uchiyama S, Wakuta M, Nomura Y, Takei N, Senju A, Tsuchiya KJ. Sex differences in neurodevelopmental trajectories in children with different levels of autistic traits. Psychiatry Clin Neurosci. 2023;77(5):282-289.
27. Nishimura T, Kato T, Okumura A, Harada T, Iwabuchi T, Rahman MS, Hirota T, Takahashi M, Adachi M, Kuwabara H, Takagai S, Nomura Y, Takahashi N, Senju A, Tsuchiya KJ. Trajectories of Adaptive Behaviors During Childhood in Females and Males in the General Population. Front Psychiatry. 2022;13:817383.
28. Ogasawara M, Takeshima M, Kosaka S, Imanishi A, Itoh Y, Fujiwara D, Yoshizawa K, Ozaki N, Nakagome K, Mishima K. Exploratory validation of sleep-tracking devices in patients with psychiatric disorders. Nature and Science of Sleep. 2023;15:301-312.
29. Oh HS, Lee BJ, Lee YS, Jang OJ, Nakagami Y, Inada T, Kato TA, Kanba S, Chong MY, Lin SK, Si TM, Xiang YT, Avasthi A, Grover S, Kallivayalil RA, Pariwatcharakul P, Chee KY, Tanra AJ, Rabbani G, Javed A, Kathiarachchi S, Myint WA, Cuong TV, Wang YX, Sim K, Sartorius N, Tan CH, Shinfuku N, Park YC, Park SC. Machine learning algorithm-based prediction model for the augmented use of clozapine with electroconvulsive therapy in patients with schizophrenia. Journal of Personalized Medicine. 2022;12(6):969.
30. Oh J, Shin HM, Nishimura T, Rahman MS, Takahashi N, Tsuchiya KJ. Perfluorooctanoate and perfluorooctane sulfonate in umbilical cord blood and child cognitive development: Hamamatsu Birth Cohort for Mothers and Children (HBC Study). Environ Int. 2022;163:107215.
31. Ohgidani M, Kushima I, Inamine S, Kyuragi S, Sagata N, Nakao T, Kanba S, Ozaki N, Kato TA. A case of bipolar disorder with aif1 (coding gene of iba-1) deletion: A pilot in vitro analysis using blood-derived microglia-like cells. Psychiatry and Clinical Neurosciences. 2023;77(2):128-130.
32. Okada I, Miyata S, Iwamoto K, Fujishiro H, Noda A, Ozaki N. Prevalence of obstructive sleep apnea as assessed by polysomnography in psychiatric patients with sleep-related problems. Sleep Breath. 2022;26(4):1983-1991.
33. Okumura H, Arioka Y, Kushima I, Mori D, Ozaki N. Establishment of induced pluripotent stem cells from a patient with 16p13.11 duplication and vps13b deletion. Stem Cell Research. 2022;64:102884.
34. Sugiyama M, Tsuchiya KJ, Okubo Y, Rahman MS, Uchiyama S, Harada T, Iwabuchi T, Okumura A, Nakayasu C, Amma Y, Suzuki H, Takahashi N, Kinsella-Kammerer B, Nomura Y, Itoh H, Nishimura T. Outdoor Play as a Mitigating Factor in the Association Between Screen Time for Young Children and Neurodevelopmental Outcomes. JAMA Pediatr. 2023;177(3):303-310.
35. sSumiyoshi C, Ohi K, Fujino H, Yamamori H, Fujimoto M, Yasuda Y, Uno Y, Takahashi J, Morita K, Katsuki A, Yamamoto M, Okahisa Y, Sata A, Katsumoto E, Koeda M, Hirano Y, Nakataki M, Matsumoto J, Miura K, Hashimoto N, Makinodan M, Takahashi T, Nemoto K, Kishimoto T, Suzuki M, Sumiyoshi T, Hashimoto R. Transdiagnostic comparisons of intellectual abilities and work outcome in patients with mental disorders: multicentre study. BJPsych Open. 2022;8(4):e98.
36. Tachibana M, Inada T, Ichida M, Ozaki N. Prevalence, clinical features, and risk factors of delusions in patients with delirium. International Journal of Geriatric Psychiatry. 2022;37(6).
37. Tachibana M, Inada T. Poor prognostic impact of delirium: especially on mortality and institutionalisation. Psychogeriatrics. 2023;23(1):187-195.
38. Tachibana M, Ishizuka K, Inada T. Catatonia and Delirium: Similarity and Overlap of Acute Brain Dysfunction. Front Psychiatry. 2022;13:876727.
39. Tainaka H, Takahashi N, Nishimura T, Okumura A, Harada T, Iwabuchi T, Rahman MS, Nomura Y, Tsuchiya KJ. Long-term effect of persistent postpartum depression on children's psychological problems in childhood. J Affect Disord. 2022;305:71-76.
40. Takase S, Liao JZ, Liu Y, Tanaka R, Miyagawa Y, Sawahata M, Sobue A, Mizoguchi H, Nagai T, Kaibuchi K, Ozaki N, Yamada K. Antipsychotic-like effects of fasudil, a rho-kinase inhibitor, in a pharmacologic animal model of schizophrenia. European Journal of Pharmacology. 2022;931.
41. Tanaka R, Liao JZ, Hada K, Mori D, Nagai T, Matsuzaki T, Nabeshima T, Kaibuchi K, Ozaki N, Mizoguchi H, Yamada K. Inhibition of rho-kinase ameliorates decreased spine density in the medial prefrontal cortex and methamphetamine-induced cognitive dysfunction in mice carrying schizophrenia-associated mutations of the arhgap10 gene. Pharmacological Research. 2023;187:106589.
42. Torii Y, Iritani S, Fujishiro H, Sekiguchi H, Habuchi C, Ikeda T, Yoshida M, Iwasaki Y, Ozaki N, Kawashima K. An autopsy case of schizophrenia comorbid with pure argyrophilic grain disease. Psychogeriatrics 2023;23(2)371-373.
43. Torii-Goto A, Yoshimi A, Tashiro Y, Ukigai M, Matsumoto A, Ozaki N, Noda Y. A reactive metabolite of clozapine induces hematopoietic toxicity in hl-60 cells undergoing granulocytic differentiation through its effect on glutathione metabolism. Biological & Pharmaceutical Bulletin. 2022;45(9):1232-1237.
44. Tsujikawa K, Hamanaka K, Riku Y, Hattori Y, Hara N, Iguchi Y, Ishigaki S, Hashizume A, Miyatake S, Mitsuhashi S, Miyazaki Y, Kataoka M, Li JY, Yasui K, Kuru S, Koike H, Kobayashi K, Sahara N, Ozaki N, Yoshida M, Kakita A, Saito Y, Iwasaki Y, Miyashita A, Iwatsubo T, Ikeuchi T, Miyata T, Sobue G, Matsumoto N, Sahashi K, Katsuno M, Japanese Alzheimer's Dis N, Japanese Longitudinal Biomarker S. Actin-binding protein filamin-a drives tau aggregation and contributes to progressive supranuclear palsy pathology. Science Advances. 2022;8(21):eabm5029.
45. Wada S, Iwamoto K, Okumura H, Hida H, Hiraoka S, Kamei A, Mori D, Yamada K, Ozaki N. Sensory evaluation of the bitterness of asenapine using d-sorbitol pretreatment: Single-blind, placebo-controlled, crossover trial. Bmc Psychiatry. 2023;23(1):159.
46. Yamaguchi S, Kaminogo K, Tokura T, Kimura H, Kishi S, Yamamoto N, Ichimura N, Toyama N, Koma Y, Kouyama N, Ozaki N, Hibi H. Psychological impact on patients with oral cancer before undergoing resection and free flap reconstruction surgery. Oral Oncology Reports. 2022;3-4:100004.
47. Yamamoto M, Bagarinao E, Shimamoto M, Iidaka T, Ozaki N. Involvement of cerebellar and subcortical connector hubs in schizophrenia. Neuroimage-Clinical. 2022;35:103140.
48. Yamasue H, Kojima M, Kuwabara H, Kuroda M, Matsumoto K, Kanai C, Inada N, Owada K, Ochi K, Ono N, Benner S, Wakuda T, Kameno Y, Inoue J, Harada T, Tsuchiya K, Umemura K, Yamauchi A, Ogawa N, Kushima I, Ozaki N, Suyama S, Saito T, Uemura Y, Hamada J, Kano Y, Honda N, Kikuchi S, Seto M, Tomita H, Miyoshi N, Matsumoto M, Kawaguchi Y, Kanai K, Ikeda M, Nakamura I, Isomura S, Hirano Y, Onitsuka T, Kosaka H, Okada T. Effect of a novel nasal oxytocin spray with enhanced bioavailability on autism: A randomized trial. Brain. 2022;145(2):490-499.
49. Yoshida M, Hasegawa S, Taniguchi M, Mouri A, Suzuki C, Yoshimi A, Mamiya T, Ozaki N, Noda Y. Memantine ameliorates the impairment of social behaviors induced by a single social defeat stress as juveniles. Neuropharmacology. 2022; 217:109208.
2021年
1. Amare AT, Schubert KO, Hou L, Clark SR, Papiol S, Cearns M, Heilbronner U, Degenhardt F, Tekola-Ayele F, Hsu YH, Shekhtman T, AdIi M, Akula N, Akiyama K, Ardau R, Arias B, Aubry JM, Backlund L, Bhattacharjee K, Bellivier F, Benabarre A, Bengesser S, Biernacka JM, Birner A, Brichant-Petitjean C, Cervantes P, Chen HC, Chillotti C, Cichon S, Cruceanu C, Czerski PM, Dalkner N, Dayer A, Del Zompo M, DePaulo JR, Etain B, Jamain S, Falkai P, Forstner AJ, Frisen L, Frye MA, Fullerton JM, Gard S, Garnham JS, Goes FS, Grigoroiu-Serbanescu M, Grof P, Hashimoto R, Hauser J, Herms S, Hoffmann P, Hofmann A, Jimenez E, Kahn JP, Kassem L, Kuo PH, Kato T, Kelsoe JR, Kittel-Schneider S, Kliwicki S, Konig B, Kusumi I, Laje G, Landen M, Lavebratt C, Leboyer M, Leckband SG, Tortorella A, Manchia M, Martinsson L, McCarthy MJ, McElroy SL, Colom F, Mitjans M, Mondimore FM, Monteleone P, Nievergelt CM, Nothen MM, Novak T, O'Donovan C, Ozaki N, Osby U, Pfennig A, Potash JB, Reif A, Reininghaus E, Rouleau GA, Rybakowski JK, Schalling M, Schofield PR, Schweizer BW, Severino G, Shilling PD, Shimoda K, Simhandl C, Slaney CM, Squassina A, Stamm T, Stopkova P, Maj M, Turecki G, Vieta E, Veeh J, Witt SH, Wright A, Zandi PP, Mitchell PB, Bauer M, Alda M, Rietschel M, McMahon FJ, Schulze TG, Baune BT, Psychiatric Genomics C. Association of polygenic score for major depression with response to lithium in patients with bipolar disorder. Molecular Psychiatry. 2021;26(6):2457-70.
3. Arioka Y, Shishido E, Kushima I, Suzuki T, Saito R, Aiba A, Mori D, Ozaki N. Chromosome 22q11.2 deletion causes perk-dependent vulnerability in dopaminergic neurons. Ebiomedicine. 2021;63:103138.
5. Arta RK, Watanabe Y, Inoue E, Nawa Y, Morikawa R, Egawa J, Kushima I, Igeta H, Hoya S, Sugimoto A, Tanra AJ, Ozaki N, Someya T. Resequencing and association analysis of gap43 with autism spectrum disorder and schizophrenia in a japanese population. Research in Autism Spectrum Disorders. 2021;82:101729.
7. Fujishiro H, Torii Y, Iritani S, Ozaki N. Dopaminergic circuitry in late-life depression and lewy body disease. Psychiatry and Clinical Neurosciences. 2021;75(2):69-70.
9. Hada K, Wulaer B, Nagai T, Itoh N, Sawahata M, Sobue A, Mizoguchi H, Mori D, Kushima I, Nabeshima T, Ozaki N, Yamada K. Mice carrying a schizophrenia-associated mutation of the arhgap10 gene are vulnerable to the effects of methamphetamine treatment on cognitive function: Association with morphological abnormalities in striatal neurons. Molecular Brain. 2021;14(1):1-17.
11. Iino K, Toriumi K, Agarie R, Miyashita M, Suzuki K, Horiuchi Y, Niizato K, Oshima K, Imai A, Nagase Y, Kushima I, Koike S, Ikegame T, Jinde S, Nagata E, Washizuka S, Miyata T, Takizawa S, Hashimoto R, Kasai K, Ozaki N, Itokawa M, Arai M. Akr1a1 variant associated with schizophrenia causes exon skipping, leading to loss of enzymatic activity. Frontiers in Genetics. 2021;12.
13. Ito M, Tokura T, Miyauchi T, Sato (Boku)　A, Kimura H, Tsuchihashi H, Katayama Y. Collaboration of perioperative management in an adult patient with 22 q 11.2 deletion syndrome: A case report. Clinical Case Reports. 2022;10(2):e05489.
15. Ito T, Hiramatsu Y, Mouri A, Yoshigai T, Takahashi A, Yoshimi A, Mamiya T, Ozaki N, Noda Y. Involvement of pkcpi-sert activity in stress vulnerability of mice exposed to twice-swim stress. Neuroscience Research. 2021;171:83-91.
17. Iwabuchi T, Takahashi N, Nishimura T, Rahman MS, Harada T, Okumura A, Kuwabara H, Takagai S, Nomura Y, Matsuzaki H, Ozaki N, Tsuchiya KJ. Affiliations expand. Associations Among Maternal Metabolic Conditions, Cord Serum Leptin Levels, and Autistic Symptoms in Children. Front Psychiatry. 2021;12:816196.
19. Iwamoto K, Iwata M, Kambe D, Imadera Y, Tachibana N, Kajiyama Y, Ando M, Ozaki N. Residual effects of zopiclone on driving performance using a standardized driving simulator among healthy volunteers. Psychopharmacology (Berl). 2022;239(3):841-850.
21. Iwata M, Iwamoto K, Kitajima I, Nogi T, Onishi K, Kajiyama Y, Nishino I, Ando M, Ozaki N. Validity and reliability of a driving simulator for evaluating the influence of medicinal drugs on driving performance. Psychopharmacology. 2021;238(3):775-86.
23. Kato T, Nishimura T, Takahashi N, Harada T, Okumura A, Iwabuchi T, Nomura Y, Senju A, Tsuchiya KJ, Takei N. Identification of neurodevelopmental transition patterns from infancy to early childhood and risk factors predicting descending transition. Sci Rep. 2022;12:4822.
25. Kato Y, Kuwabara H, Okada T, Munesue T, Benner S, Kuroda M, Kojima M, Yassin W, Eriguchi Y, Kameno Y, Murayama C, Nishimura T, Tsuchiya K, Kasai K, Ozaki N, Kosaka H, Yamasue H. Oxytocin-induced increase in n,n-dimethylglycine and time course of changes in oxytocin efficacy for autism social core symptoms. Molecular Autism. 2021;12(1):1-13.
27. Kawabata K, Bagarinao E, Watanabe H, Maesawa S, Mori D, Hara K, Ohdake R, Masuda M, Ogura A, Kato T, Koyama S, Katsuno M, Wakabayashi T, Kuzuya M, Hoshiyama M, Isoda H, Naganawa S, Ozaki N, Sobue G. Bridging large-scale cortical networks: Integrative and function-specific hubs in the thalamus. Iscience. 2021;24(10):103106.
29. Kimura H, Mori D, Aleksic B, Ozaki N. Elucidation of molecular pathogenesis and drug development for psychiatric disorders from rare disease-susceptibility variants. Neuroscience Research. 2021;170:24-31.
31. Le Clerc S, Lombardi L, Baune BT, Amare AT, Schubert KO, Hou LP, Clark SR, Papiol S, Cearns M, Heilbronner U, Degenhardt F, Tekola-Ayele F, Hsu YH, Shekhtman T, Adli M, Akula N, Akiyama K, Ardau R, Arias B, Aubry JM, Backlund L, Bhattacharjee AK, Bellivier F, Benabarre A, Bengesser S, Biernacka JM, Birner A, Brichant-Petitjean C, Cervantes P, Chen HC, Chillotti C, Cichon S, Cruceanu C, Czerski PM, Dalkner N, Dayer A, Del Zompo M, DePaulo JR, Etain B, Jamain S, Falkai P, Forstner AJ, Frisen L, Frye MA, Fullerton JM, Gard S, Garnham JS, Goes FS, Grigoroiu-Serbanescu M, Grof P, Hashimoto R, Hauser J, Herms S, Hofmann P, Jimenez E, Kahn JP, Kassem L, Kuo PH, Kato T, Kelsoe JR, Kittel-Schneider S, Ferensztajn-Rochowiak E, Konig B, Kusumi I, Laje G, Landen M, Lavebratt C, Leckband S, Tortorella A, Manchia M, Martinsson L, McCarthy MJ, McElroy SL, Colom F, Millischer V, Mitjans M, Mondimore FM, Monteleone P, Nievergelt CM, Nothen MM, Novak T, O'Donovan C, Ozaki N, Osby U, Pfennig A, Potash JB, Reif A, Reininghaus E, Rouleau GA, Rybakowski JK, Schalling M, Schofeld PR, Schweizer BW, Severino G, Shilling PD, Shimoda K, Simhandl C, Slaney CM, Pisanu C, Squassina A, Stamm T, Stopkova P, Maj M, Turecki G, Vieta E, Veeh J, Witt SH, Wright A, Zandi PP, Mitchell PB, Bauer M, Alda M, Rietschel M, McMahon FJ, Schulze TG, Boukouaci W, Richard JR, Le Corvoisier P, Barrau C, Zagury JF, Leboyer M, Tamouza R. Hla-drb1 and hla-dqb1 genetic diversity modulates response to lithium in bipolar affective disorders. Scientific Reports. 2021;11(1):1-12.
33. Lim K, Lam M, Zai C, Tay J, Karlsson N, Deshpande SN, Thelma BK, Ozaki N, Inada T, Sim K, Chong SA, Lencz T, Liu JJ, Lee J. Genome wide study of tardive dyskinesia in schizophrenia. Translational Psychiatry. 2021;11(1):1-10.
35. Maesawa S, Mizuno S, Bagarinao E, Watanabe H, Kawabata K, Hara K, Ohdake R, Ogura A, Mori D, Nakatsubo D, Isoda H, Hoshiyama M, Katsuno M, Saito R, Ozaki N, Sobue G. Resting state networks related to the maintenance of good cognitive performance during healthy aging. Frontiers in Human Neuroscience. 2021;15:1-18.
37. Miyata S, Iwamoto K, Banno M, Eguchi J, Kaneko S, Noda A, Ozaki N. Performance of an ambulatory electroencephalogram sleep monitor in patients with psychiatric disorders. Journal of Sleep Research. 2021;30(4):e13273.
39. Mizutani R, Saiga R, Yamamoto Y, Uesugi M, Takeuchi A, Uesugi K, Terada Y, Suzuki Y, De Andrade V, De Carlo F, Takekoshi S, Inomoto C, Nakamura N, Torii Y, Kushima I, Iritani S, Ozaki N, Oshima K, Itokawa M, Arai M. Structural diverseness of neurons between brain areas and between cases. Translational Psychiatry. 2021;11(1): 1-9.
41. Nakamura M, Yoshimi A, Mouri A, Tokura T, Kimura H, Kishi S, Miyauchi T, Iwamoto K, Ito M, Sato-Boku A, Ozaki N, Nabeshima T, Noda Y. Duloxetine attenuates pain in association with downregulation of platelet serotonin transporter in patients with burning mouth syndrome and atypical odontalgia. Human Psychopharmacology -Clinical and Experimental. 2022;7(2):e2818.
43. Nakatochi M, Kushima I, Ozaki N. Implications of germline copy-number variations in psychiatric disorders: Review of large-scale genetic studies. Journal of Human Genetics. 2021;66(1):25-37.
45. Nishida Y, Ikuta K, Natsume A, Ishihara N, Morikawa M, Kidokoro H, Muramatsu Y, Nonobe N, Ishizuka K, Takeichi T, Kanbe M, Mizuno S, Imagama S, Ozaki N. Establishment of in-hospital clinical network for patients with neurofibromatosis type 1 in nagoya university hospital. Scientific Reports. 2021;11(1): 1-7.
47. Nishimura T, Kato T, Okumura A, Harada T, Iwabuchi T, Rahman MS, Hirota T, Takahashi M, Adachi M, Kuwabara H, Takagai S, Nomura Y, Takahashi N, Senju A, Tsuchiya KJ. Trajectories of Adaptive Behaviors During Childhood in Females and Males in the General Population. Front Psychiatry. 2022;13:817383.
49. Nitta A, Izuo N, Hamatani K, Inagaki R, Kusui Y, Fu KQ, Asano T, Torii Y, Habuchi C, Sekiguchi H, Iritani S, Muramatsu S, Ozaki N, Miyamoto Y. Schizophrenia-like behavioral impairments in mice with suppressed expression of piccolo in the medial prefrontal cortex. Journal of Personalized Medicine. 2021;11(7):607.
51. Noda Y, Soeda K, Uchida M, Goto S, Ito T, Kitagaki S, Mamiya T, Yoshimi A, Ozaki N, Mouri A. Multiple nicotinic acetylcholine receptor subtypes regulate social or cognitive behaviors in mice repeatedly administered phencyclidine. Behavioural Brain Research. 2021;408: 113284.
53. Ogasawara K, Numata S, Hasegawa N, Nakataki,M, Makinodan M , Ohi K, Takeshima M, Tsuboi T, Hashimoto N, Onitsuka T, Muraoka H, Hori H, Ichihashi K, Inagaki T, Yasui-Furukori N, Hishimoto A, Sugiyama N, Fukumoto K, Nagasawa,T, Matsumoto J, Takaesu Y, Furihata,R, Nemoto K, Nakamura T, Usami M, Miura K, Fujimoto M, Tagata H, Yamada H, Komatsu H, Ochi S, Atake K, Katsumoto E, Kido M, Kishimoto T, Suwa T, Yamamura S, Iga J, Iida H, Inada K, Watanabe K, Hashimoto R. Subjective assessment of participants in education programs on clinical practice guidelines in the field of psychiatry. Neuropsychopharmacology Reports. 2022 Mar 10. doi: 10.1002/npr2.12245
55. Oh J, Shin HM, Nishimura T, Rahman MS, Takahashi N, Tsuchiya KJ. Perfluorooctanoate and perfluorooctane sulfonate in umbilical cord blood and child cognitive development: Hamamatsu Birth Cohort for Mothers and Children (HBC Study). Environ Int. 2022;163:107215.
57. Okada I, Iwamoto K, Miyata S, Fujimoto A, Tanaka M, Amano M, Matsuyama N, Taoka T, Naganawa S, Ozaki N. Fluid study: Study protocol for an open-label, single-centre pilot study to investigate the effect of lemborexant on sleep management in japanese subjects aged 50 years and older with insomnia disorder. Bmj Open. 2021;11(11): e054885.
59. Okuda M, Noda A, Iwamoto K, Nakashima H, Takeda K, Miyata S, Yasuma F, Ozaki N, Shimouchi A. Effects of long sleep time and irregular sleep-wake rhythm on cognitive function in older people. Scientific Reports. 2021;11(1):1-10.
61. Okuda M, Noda A, Mabuchi S, Iwamoto K, Banno M, Miyata S, Yasuma F, Ozaki N. Sleep fragmentation and working memory in healthy adults. Sleep Science. 2021;14:111-117.
63. Rahman MS, Takahashi N, Iwabuchi T, Nishimura T, Harada T, Okumura A, Takei N, Nomura Y, Tsuchiya KJ. Elevated risk of attention deficit hyperactivity disorder (ADHD) in Japanese children with higher genetic susceptibility to ADHD with a birth weight under 2000 g. BMC Med. 2021;19:229.
65. Saiga R, Uesugi M, Takeuchi A, Uesugi K, Suzuki Y, Takekoshi S, Inomoto C, Nakamura N, Torii Y, Kushima I, Iritani S, Ozaki N, Oshima K, Itokawa M, Arai M, Mizutani R. Brain capillary structures of schizophrenia cases and controls show a correlation with their neuron structures. Scientific Reports. 2021;11(1):1-9.
67. Saito R, Miyoshi C, Koebis M, Kushima I, Nakao K, Mori D, Ozaki N, Funato H, Yanagisawa M, Aiba A. Two novel mouse models mimicking minor deletions in 22q11.2 deletion syndrome revealed the contribution of each deleted region to psychiatric disorders. Molecular Brain. 2021;14(1):1-15.
69. Sato A, Kimura H, Tokura T, Umemura E, Miyauchi T, Ito M, Kishi S, Ogi N, Tonoike T, Ozaki N, Nakano Y, Okuda M. Evaluation of patients suffered from burning mouth syndrome and persistent idiopathic facial pain using japanese version paindetect questionnaire and depression scales. Journal of Dental Sciences. 2021;16(1):131-136.
71. Sato M, Okada T, Morikawa M, Nakamura Y, Yamauchi A, Ando M, Ozaki N. Validation and factor analysis of the parental bonding instrument in japanese pregnant women. Scientific Reports. 2021;11(1):1-10.
73. Schubert KO, Thalamuthu A, Amare AT, Frank J, Streit F, Adl M, Akula N, Akiyama K, Ardau R, Arias B, Aubry JM, Backlund L, Bhattacharjee AK, Bellivier F, Benabarre A, Bengesser S, Biernacka JM, Birner A, Marie-Claire C, Cearns M, Cervantes P, Chen HC, Chillotti C, Cichon S, Clark SR, Cruceanu C, Czerski PM, Dalkner N, Dayer A, Degenhardt F, Del Zompo M, DePaulo JR, Etain B, Falkai P, Forstner AJ, Frisen L, Frye MA, Fullerton JM, Gard S, Garnham JS, Goes FS, Grigoroiu-Serbanescu M, Grof P, Hashimoto R, Hauser J, Heilbronner U, Herms S, Hoffmann P, Hou LP, Hsu YH, Jamain S, Jimenez E, Kahn JP, Kassem L, Kuo PH, Kato T, Kelsoe J, Kittel-Schneider S, Ferensztajn-Rochowiak E, Konig B, Kusumi I, Laje G, Landen M, Lavebratt C, Leboyer M, Leckband SG, Maj M, Manchia M, Martinsson L, McCarthy MJ, McElroy S, Colom F, Mitjans M, Mondimore FM, Monteleone P, Nievergelt CM, Nothen MM, Novak T, O'Donovan C, Ozaki N, Osby U, Papiol S, Pfennig A, Pisanu C, Potash JB, Reif A, Reininghaus E, Rouleau GA, Rybakowski JK, Schalling M, Schofield PR, Schweizer BW, Severino G, Shekhtman T, Shilling PD, Shimoda K, Simhandl C, Slaney CM, Squassina A, Stamm T, Stopkova P, Tekola-Ayele F, Tortorella A, Turecki G, Veeh J, Vieta E, Witt SH, Roberts G, Zandi PP, Alda M, Bauer M, McMahon FJ, Mitchell PB, Schulze TG, Rietschel M, Baune BT, Psychiat Genomics C. Combining schizophrenia and depression polygenic risk scores improves the genetic prediction of lithium response in bipolar disorder patients. Translational Psychiatry. 2021;11(1):1-8.
75. Sekiguchi H, Fujishiro H, Torii Y, Iritani S, Ozaki N. Can we identify prodromal dementia with lewy bodies in late-life depression? Psychiatry and Clinical Neurosciences. 2021;75(3):113-114.
77. Shizuku M, Kimura H, Kamei H, Kishi S, Tokura T, Kurata N, Jobara K, Yoshizawa A, Tsuboi C, Yamaguchi N, Kato M, Kawai K, Yamashiki M, Kanai E, Ishizuka K, Ozaki N, Ogura Y. Psychosocial characteristics of alcoholic and non-alcoholic liver disease recipient candidates in liver transplantation: A prospective observational study. Bmc Gastroenterology. 2021;21(1):1-10.
79. Stone W, Nunes A, Akiyama K, Akula N, Ardau R, Aubry JM, Backlund L, Bauer M, Bellivier F, Cervantes P, Chen HC, Chillotti C, Cruceanu C, Dayer A, Degenhardt F, Del Zompo M, Forstner AJ, Frye M, Fullerton JM, Grigoroiu-Serbanescu M, Grof P, Hashimoto R, Hou LP, Jimenez E, Kato T, Kelsoe J, Kittel-Schneider S, Kuo PH, Kusumi I, Lavebratt C, Manchia M, Martinsson L, Mattheisen M, McMahon FJ, Millischer V, Mitchell PB, Nothen MM, O'Donovan C, Ozaki N, Pisanu C, Reif A, Rietschel M, Rouleau G, Rybakowski J, Schalling M, Schofield PR, Schulze TG, Severino G, Squassina A, Veeh J, Vieta E, Trappenberg T, Alda M. Prediction of lithium response using genomic data. Scientific Reports. 2021;11(1):1-10.
81. Tachibana M, Inada T, Ichida M, Kojima S, Arai T, Naito K, Ozaki N. Significant decrease in delirium referrals after changing hypnotic from benzodiazepine to suvorexant. Psychogeriatrics. 2021;21(3):324-332.
83. Tachibana M, Inada T, Ichida M, Kojima S, Shioya M, Wakayama K, Ozaki N. Factors associated with the severity of delirium. Human Psychopharmacology-Clinical and Experimental. 2021;36(5):e2787.
85. Tachibana M, Inada T, Ichida M, Ozaki N. Risk factors for inducing violence in patients with delirium. Brain and Behavior. 2021;11(8):e2276.
87. Tachibana M, Inada T, Ichida M, Ozaki N. Factors affecting hallucinations in patients with delirium. Scientific Reports. 2021;11(1):1-6.
89. Takahashi N, Okumura A, Nishimura T, Harada T, Iwabuchi T, Rahman MS, Tsuchiya KJ. Exploration of Sleep Parameters, Daytime Hyperactivity/Inattention, and Attention-Deficit/Hyperactivity Disorder Polygenic Risk Scores of Children in a Birth Cohort in Japan. JAMA Netw Open. 2022;5:e2141768.
91. Takahashi N, Nishimura T, Harada T, Okumura A, Iwabuchi T, Rahman MS, Kuwabara H, Takagai S, Nomura Y, Takei N, Tsuchiya KJ. Association Between Genetic Risks for Obesity and Working Memory in Children. Front Neurosci. 2021;15:749230.
93. Takahashi N, Ishizuka K, Inada T. Peripheral biomarkers of attention-deficit hyperactivity disorder: Current status and future perspective. J Psychiatr Res. 2021;137:465-70.
95. Tsuneura Y, Sawahata M, Itoh N, Miyajima R, Mori D, Kohno T, Hattori M, Sobue A, Nagai T, Mizoguchi H, Nabeshima T, Ozaki N, Yamada K. Analysis of reelin signaling and neurodevelopmental trajectory in primary cultured cortical neurons with reln deletion identified in schizophrenia. Neurochemistry International. 2021;144:104954.
97. Uchida M, Noda Y, Hasegawa S, Hida H, Taniguchi M, Mouri A, Yoshimi A, Nabeshima T, Yamada K, Aida T, Tanaka K, Ozaki N. Early postnatal inhibition of glast causes abnormalities of psychobehaviors and neuronal morphology in adult mice. Neurochemistry International. 2021;150:105177.
99. Yoshikawa A, Kushima I, Miyashita M, Toriumi K, Suzuki K, Horiuchi Y, Kawaji H, Takizawa S, Ozaki N, Itokawa M, Arai M. Dysregulation of post-transcriptional modification by copy number variable micrornas in schizophrenia with enhanced glycation stress. Translational Psychiatry. 2021;11(1):1-11.
2020年
1. Amare AT, Schubert KO, Hou L, Clark SR, Papiol S, Cearns M, Heilbronner U, Degenhardt F, Tekola-Ayele F, Hsu YH, Shekhtman T, Adli M, Akula N, Akiyama K, Ardau R, Arias B, Aubry JM, Backlund L, Bhattacharjee AK, Bellivier F, Benabarre A, Bengesser S, Biernacka JM, Birner A, Brichant-Petitjean C, Cervantes P, Chen HC, Chillotti C, Cichon S, Cruceanu C, Czerski PM, Dalkner N, Dayer A, Del Zompo M, DePaulo JR, Étain B, Jamain S, Falkai P, Forstner AJ, Frisen L, Frye MA, Fullerton JM, Gard S, Garnham JS, Goes FS, Grigoroiu-Serbanescu M, Grof P, Hashimoto R, Hauser J, Herms S, Hoffmann P, Hofmann A, Jiménez E, Kahn JP, Kassem L, Kuo PH, Kato T, Kelsoe JR, Kittel-Schneider S, Kliwicki S, König B, Kusumi I, Laje G, Landén M, Lavebratt C, Leboyer M, Leckband SG, Tortorella A, Manchia M, Martinsson L, McCarthy MJ, McElroy SL, Colom F, Mitjans M, Mondimore FM, Monteleone P, Nievergelt CM, Nöthen MM, Novák T, O'Donovan C, Ozaki N, Ösby U, Pfennig A, Potash JB, Reif A, Reininghaus E, Rouleau GA, Rybakowski JK, Schalling M, Schofield PR, Schweizer BW, Severino G, Shilling PD, Shimoda K, Simhandl C, Slaney CM, Squassina A, Stamm T, Stopkova P, Maj M, Turecki G, Vieta E, Veeh J, Witt SH, Wright A, Zandi PP, Mitchell PB, Bauer M, Alda M, Rietschel M, McMahon FJ, Schulze TG, Baune BT. Association of polygenic score for major depression with response to lithium in patients with bipolar disorder. Molecular psychiatry. 2020. https://doi.org/10.1038/s41380-020-0689-5
3. Arioka Y, Hirata A, Kushima I, Aleksic B, Mori D, Ozaki N. Characterization of a schizophrenia patient with a rare reln deletion by combining genomic and patient-derived cell analyses. Schizophrenia research. 2020;216:511-5.
5. Arioka Y, Shishido E, Kushima I, Mori D, Ozaki N. Cell body shape and directional movement stability in human-induced pluripotent stem cell-derived dopaminergic neurons. Scientific reports. 2020;10(1):5820.
7. Bagarinao E, Watanabe H, Maesawa S, Mori D, Hara K, Kawabata K, Ohdake R, Masuda M, Ogura A, Kato T, Koyama S, Katsuno M, Wakabayashi T, Kuzuya M, Hoshiyama M, Isoda H, Naganawa S, Ozaki N, Sobue G. Identifying the brain's connector hubs at the voxel level using functional connectivity overlap ratio. NeuroImage. 2020;222:117241.
9. Bagarinao E, Watanabe H, Maesawa S, Mori D, Hara K, Kawabata K, Yoneyama N, Ohdake R, Imai K, Masuda M, Yokoi T, Ogura A, Taoka T, Koyama S, Tanabe HC, Katsuno M, Wakabayashi T, Kuzuya M, Hoshiyama M, Isoda H, Naganawa S, Ozaki N, Sobue G. Aging impacts the overall connectivity strength of regions critical for information transfer among brain networks. Frontiers in aging neuroscience. 2020;12:592469.
11. Choy SW, Bagarinao E, Watanabe H, Ho ETW, Maesawa S, Mori D, Hara K, Kawabata K, Yoneyama N, Ohdake R, Imai K, Masuda M, Yokoi T, Ogura A, Taoka T, Koyama S, Tanabe HC, Katsuno M, Wakabayashi T, Kuzuya M, Hoshiyama M, Isoda H, Naganawa S, Ozaki N, Sobue G. Changes in white matter fiber density and morphology across the adult lifespan: A cross-sectional fixel-based analysis. Human brain mapping. 2020;41(12):3198-211.
13. Ishizuka K, Yoshida T, Kawabata T, Imai A, Mori H, Kimura H, Inada T, Okahisa Y, Egawa J, Usami M, Kushima I, Morikawa M, Okada T, Ikeda M, Branko A, Mori D, Someya T, Iwata N, Ozaki N. Functional characterization of rare nrxn1 variants identified in autism spectrum disorders and schizophrenia. Journal of neurodevelopmental disorders. 2020;12(1):25.
15. Ito T, Hiramatsu Y, Uchida M, Yoshimi A, Mamiya T, Mouri A, Ozaki N, Noda Y. Involvement of protein kinase c beta1-serotonin transporter system dysfunction in emotional behaviors in stressed mice. Neurochemistry international. 2020;140:104826.
17. Ito Y, Maesawa S, Bagarinao E, Okai Y, Nakatsubo D, Yamamoto H, Kidokoro H, Usui N, Natsume J, Hoshiyama M, Wakabayashi T, Sobue G, Ozaki N. Subsecond eeg-fmri analysis for presurgical evaluation in focal epilepsy. Journal of neurosurgery. 2020:1-10.
19. Itokawa M, Oshima K, Arai M, Torii Y, Kushima I, Iritani S, Ozaki N, Saiga R, Mizutani R. Cutting-edge morphological studies of post-mortem brains of patients with schizophrenia and potential applications of x-ray nanotomography (nano-ct). Psychiatry and clinical neurosciences. 2020;74(3):176-82.
21. Kato K, Noda A, Yasuma F, Matsubara Y, Miyata S, Iwamoto K, Miyazaki S, Ozaki N. Effects of sleep-disordered breathing and hypertension on cognitive function in elderly adults. Clinical and experimental hypertension (New York, NY : 1993). 2020;42(3):250-6.
23. Kato S, Bagarinao E, Isoda H, Koyama S, Watanabe H, Maesawa S, Mori D, Hara K, Katsuno M, Hoshiyama M, Naganawa S, Ozaki N, Sobue G. Effects of head motion on the evaluation of age-related brain network changes using resting state functional mri. Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine. 2020.
25. Kimura H, Mori D, Aleksic B, Ozaki N. Elucidation of molecular pathogenesis and drug development for psychiatric disorders from rare disease-susceptibility variants. Neuroscience research. 2020.
27. Koshiyama D, Fukunaga M, Okada N, Morita K, Nemoto K, Usui K, Yamamori H, Yasuda Y, Fujimoto M, Kudo N, Azechi H, Watanabe Y, Hashimoto N, Narita H, Kusumi I, Ohi K, Shimada T, Kataoka Y, Yamamoto M, Ozaki N, Okada G, Okamoto Y, Harada K, Matsuo K, Yamasue H, Abe O, Hashimoto R, Takahashi T, Hori T, Nakataki M, Onitsuka T, Holleran L, Jahanshad N, van Erp TGM, Turner J, Donohoe G, Thompson PM, Kasai K, Hashimoto R. White matter microstructural alterations across four major psychiatric disorders: Mega-analysis study in 2937 individuals. Molecular psychiatry. 2020;25(4):883-95.
29. Kubota C, Inada T, Nakamura Y, Shiino T, Ando M, Aleksic B, Yamauchi A, Morikawa M, Okada T, Ohara M, Sato M, Murase S, Goto S, Kanai A, Ozaki N. Validation and factor structure of the japanese version of the inventory to diagnose depression, lifetime version for pregnant women. PloS one. 2020;15(6):e0234240.
31. Kubota C, Inada T, Shiino T, Ando M, Sato M, Nakamura Y, Yamauchi A, Morikawa M, Okada T, Ohara M, Aleksic B, Murase S, Goto S, Kanai A, Ozaki N. The risk factors predicting suicidal ideation among perinatal women in japan. Frontiers in psychiatry. 2020;11:441.
33. Lim ET, Uddin M, De Rubeis S, Chan Y, Kamumbu AS, Zhang X, D'Gama AM, Kim SN, Hill RS, Goldberg AP, Poultney C, Minshew NJ, Kushima I, Aleksic B, Ozaki N, Parellada M, Arango C, Penzol MJ, Carracedo A, Kolevzon A, Hultman CM, Weiss LA, Fromer M, Chiocchetti AG, Freitag CM, Church GM, Scherer SW, Buxbaum JD, Walsh CA. Publisher correction: Rates, distribution and implications of postzygotic mosaic mutations in autism spectrum disorder. Nature neuroscience. 2020;23(9):1176.
35. Miyata S, Iwamoto K, Banno M, Eguchi J, Kaneko S, Noda A, Ozaki N. Performance of an ambulatory electroencephalogram sleep monitor in patients with psychiatric disorders. Journal of sleep research. 2020:e13273.
37. Miyata S, Otake H, Ando M, Okuda M, Fujishiro H, Iwamoto K, Noda A, Sone M, Ozaki N. Patient characteristics affecting accurate detection of sleep apnea using a bed sheet-type portable monitor. Sleep & breathing = Schlaf & Atmung. 2020;24(2):783-90.
39. Mukoyama N, Nishio N, Kimura H, Kishi S, Tokura T, Kimura H, Hiramatsu M, Maruo T, Tsuzuki H, Fujii M, Iwami K, Takanari K, Kamei Y, Ozaki N, Sone M, Fujimoto Y. Prospective evaluation of health-related quality of life in patients undergoing anterolateral craniofacial resection with orbital exenteration. Journal of neurological surgery Part B, Skull base. 2020;81(5):585-93.
41. Nakamura Y, Okada T, Morikawa M, Yamauchi A, Sato M, Ando M, Ozaki N. Perinatal depression and anxiety of primipara is higher than that of multipara in japanese women. Scientific reports. 2020;10(1):17060.
43. Noda Y, Uchida M, Mouri A, Yamada S, Goto S, Kitagaki S, Mamiya T, Kushima I, Arioka Y, Ozaki N, Yoshimi A. Involvement of nicotinic acetylcholine receptors in behavioral abnormalities and psychological dependence in schizophrenia-like model mice. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. 2020;41:92-105.
45. Saito R, Koebis M, Nagai T, Shimizu K, Liao J, Wulaer B, Sugaya Y, Nagahama K, Uesaka N, Kushima I, Mori D, Maruyama K, Nakao K, Kurihara H, Yamada K, Kano M, Fukada Y, Ozaki N, Aiba A. Comprehensive analysis of a novel mouse model of the 22q11.2 deletion syndrome: A model with the most common 3.0-mb deletion at the human 22q11.2 locus. Translational psychiatry. 2020;10(1):35.
47. Sakurai M, Yamamoto Y, Kanayama N, Hasegawa M, Mouri A, Takemura M, Matsunami H, Miyauchi T, Tokura T, Kimura H, Ito M, Umemura E, Boku AS, Nagashima W, Tonoike T, Kurita K, Ozaki N, Nabeshima T, Saito K. Serum metabolic profiles of the tryptophan-kynurenine pathway in the high risk subjects of major depressive disorder. Scientific reports. 2020;10(1):1961.
49. Sawahata M, Mori D, Arioka Y, Kubo H, Kushima I, Kitagawa K, Sobue A, Shishido E, Sekiguchi M, Kodama A, Ikeda R, Aleksic B, Kimura H, Ishizuka K, Nagai T, Kaibuchi K, Nabeshima T, Yamada K, Ozaki N. Generation and analysis of novel reln-deleted mouse model corresponding to exonic reln deletion in schizophrenia. Psychiatry and clinical neurosciences. 2020;74(5):318-27.
51. Sekiguchi M, Sobue A, Kushima I, Wang C, Arioka Y, Kato H, Kodama A, Kubo H, Ito N, Sawahata M, Hada K, Ikeda R, Shinno M, Mizukoshi C, Tsujimura K, Yoshimi A, Ishizuka K, Takasaki Y, Kimura H, Xing J, Yu Y, Yamamoto M, Okada T, Shishido E, Inada T, Nakatochi M, Takano T, Kuroda K, Amano M, Aleksic B, Yamomoto T, Sakuma T, Aida T, Tanaka K, Hashimoto R, Arai M, Ikeda M, Iwata N, Shimamura T, Nagai T, Nabeshima T, Kaibuchi K, Yamada K, Mori D, Ozaki N. Arhgap10, which encodes rho gtpase-activating protein 10, is a novel gene for schizophrenia risk. Translational psychiatry. 2020;10(1):247.
53. Shizuku M, Kamei H, Kimura H, Kurata N, Jobara K, Yoshizawa A, Ishizuka K, Okada A, Kishi S, Ozaki N, Ogura Y. Clinical features and long-term outcomes of living donors of liver transplantation who developed psychiatric disorders. Annals of transplantation. 2020;25:e918500.
55. Suzuki T, Suzuki T, Raveau M, Miyake N, Sudo G, Tsurusaki Y, Watanabe T, Sugaya Y, Tatsukawa T, Mazaki E, Shimohata A, Kushima I, Aleksic B, Shiino T, Toyota T, Iwayama Y, Nakaoka K, Ohmori I, Sasaki A, Watanabe K, Hirose S, Kaneko S, Inoue Y, Yoshikawa T, Ozaki N, Kano M, Shimoji T, Matsumoto N, Yamakawa K. A recurrent pja1 variant in trigonocephaly and neurodevelopmental disorders. Annals of clinical and translational neurology. 2020;7(7):1117-31.
57. Taniguchi S, Ninomiya K, Kushima I, Saito T, Shimasaki A, Sakusabe T, Momozawa Y, Kubo M, Kamatani Y, Ozaki N, Ikeda M, Iwata N. Polygenic risk scores in schizophrenia with clinically significant copy number variants. Psychiatry and clinical neurosciences. 2020;74(1):35-9.
59. Torii Y, Iritani S, Marui T, Sekiguchi H, Habuchi C, Fujishiro H, Kushima I, Oshima K, Niizato K, Hayashida S, Masaki K, Kira JI, Yoshida M, Ozaki N. Morphological alteration of myelin-oligodendrocytes in a schizophrenic patient with 22q11.2 deletion syndrome: An autopsy study. Schizophrenia research. 2020;223:353-5.
61. Torii Y, Iritani S, Sekiguchi H, Habuchi C, Fujishiro H, Kushima I, Kawakami I, Itokawa M, Arai M, Hayashida S, Masaki K, Kira JI, Kawashima K, Ozaki N. The accumulation of advanced glycation end-products in a schizophrenic patient with a glyoxalase 1 frameshift mutation: An autopsy study. Schizophrenia research. 2020;223:356-8.
63. Yamamoto M, Bagarinao E, Kushima I, Takahashi T, Sasabayashi D, Inada T, Suzuki M, Iidaka T, Ozaki N. Support vector machine-based classification of schizophrenia patients and healthy controls using structural magnetic resonance imaging from two independent sites. PloS one. 2020;15(11):e0239615.
65. Yamasue H, Okada T, Munesue T, Kuroda M, Fujioka T, Uno Y, Matsumoto K, Kuwabara H, Mori D, Okamoto Y, Yoshimura Y, Kawakubo Y, Arioka Y, Kojima M, Yuhi T, Owada K, Yassin W, Kushima I, Benner S, Ogawa N, Eriguchi Y, Kawano N, Uemura Y, Yamamoto M, Kano Y, Kasai K, Higashida H, Ozaki N, Kosaka H. Effect of intranasal oxytocin on the core social symptoms of autism spectrum disorder: A randomized clinical trial. Molecular psychiatry. 2020;25(8):1849-58.
67. Yu Y, Chaulagain A, Pedersen SA, Lydersen S, Leventhal BL, Szatmari P, Aleksic B, Ozaki N, Skokauskas N. Pharmacotherapy of restricted/repetitive behavior in autism spectrum disorder:A systematic review and meta-analysis. BMC psychiatry. 2020;20(1):121.
69. Yuka K, Nishizawa D, Hasegawa J, Uno K, Miyanishi H, Ujike H, Ozaki N, Inada T, Iwata N, Sora I, Iyo M, Yamada M, Kondo N, Won MJ, Naruse N, Uehara-Aoyama K, Ikeda K, Nitta A. A single medical marker for diagnosis of methamphetamine addiction - DNA methylation of shati/nat8l promoter sites from patient blood. Current pharmaceutical design. 2020;26(2):260-4.
2019年
1. Baba M, Yokoyama K, Seiriki K, Naka Y, Matsumura K, Kondo M, Yamamoto K, Hayashida M, Kasai A, Ago Y, Nagayasu K, Hayata-Takano A, Takahashi A, Yamaguchi S, Mori D, Ozaki N, Yamamoto T, Takuma K, Hashimoto R, Hashimoto H, Nakazawa T. Psychiatric-disorder-related behavioral phenotypes and cortical hyperactivity in a mouse model of 3q29 deletion syndrome. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2019;44(12):2125-35.
2. Bagarinao E, Watanabe H, Maesawa S, Mori D, Hara K, Kawabata K, Yoneyama N, Ohdake R, Imai K, Masuda M, Yokoi T, Ogura A, Taoka T, Koyama S, Tanabe HC, Katsuno M, Wakabayashi T, Kuzuya M, Ozaki N, Hoshiyama M, Isoda H, Naganawa S, Sobue G. Reorganization of brain networks and its association with general cognitive performance over the adult lifespan. Scientific reports. 2019;9(1):11352.
3. Fujishiro H, Kimura H, Nakamura T, Torii Y, Iritani S, Ozaki N. Hypochondriasis in the elderly and lewy body disease. Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society. 2019;19(5):516-8.
4. Fujishiro H, Okuda M, Iwamoto K, Miyata S, Torii Y, Iritani S, Ozaki N. Clinical profiles of late-onset psychiatric patients exhibiting incidental rem sleep without atonia. Journal of neural transmission (Vienna, Austria : 1996). 2019;126(8):1095-104.
5. Hasegawa S, Yoshimi A, Mouri A, Uchida Y, Hida H, Mishina M, Yamada K, Ozaki N, Nabeshima T, Noda Y. Acute administration of ketamine attenuates the impairment of social behaviors induced by social defeat stress exposure as juveniles via activation of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (ampa) receptors. Neuropharmacology. 2019;148:107-16.
6. Hayakawa N, Tanaka S, Hirata N, Ogino S, Ozaki N. A battery of self-screening instruments and self-reported body frame could not detect eating disorders among college students. BMC research notes. 2019;12(1):613.
7. Hirano M, Iritani S, Fujishiro H, Torii Y, Habuchi C, Sekiguchi H, Yoshida M, Ozaki N. Clinicopathological differences between the motor onset and psychiatric onset of huntington's disease, focusing on the nucleus accumbens. Neuropathology : official journal of the Japanese Society of Neuropathology. 2019;39(5):331-41.
8. Ikeda M, Takahashi A, Kamatani Y, Momozawa Y, Saito T, Kondo K, Shimasaki A, Kawase K, Sakusabe T, Iwayama Y, Toyota T, Wakuda T, Kikuchi M, Kanahara N, Yamamori H, Yasuda Y, Watanabe Y, Hoya S, Aleksic B, Kushima I, Arai H, Takaki M, Hattori K, Kunugi H, Okahisa Y, Ohnuma T, Ozaki N, Someya T, Hashimoto R, Yoshikawa T, Kubo M, Iwata N. Genome-wide association study detected novel susceptibility genes for schizophrenia and shared trans-populations/diseases genetic effect. Schizophrenia bulletin. 2019;45(4):824-34.
9. Ishii T, Ishikawa M, Fujimori K, Maeda T, Kushima I, Arioka Y, Mori D, Nakatake Y, Yamagata B, Nio S, Kato TA, Yang N, Wernig M, Kanba S, Mimura M, Ozaki N, Okano H. In vitro modeling of the bipolar disorder and schizophrenia using patient-derived induced pluripotent stem cells with copy number variations of pcdh15 and reln. eNeuro. 2019;6(5).
10. Iwata M, Iwamoto K, Omura T, Ando M, Ozaki N. Protocol for the development and validation of a driving simulator for evaluating the influence of drugs on driving performance. Medicine. 2019;98(8):e14613.
11. Kato H, Ozaki N. [the considerations for diagnosis of autism spectrum disorders and its pathogenic mechanisms]. Rinsho shinkeigaku = Clinical neurology. 2019;59(1):13-20.
12. Kawakubo H, Matsui Y, Kushima I, Ozaki N, Shimamura T. A network of networks approach for modeling interconnected brain tissue-specific networks. Bioinformatics (Oxford, England). 2019;35(17):3092-101.
13. Kubota C, Inada T, Shiino T, Ando M, Aleksic B, Yamauchi A, Sato M, Ohara M, Murase S, Morikawa M, Nakamura Y, Okada T, Goto S, Kanai A, Ozaki N. Relation between perinatal depressive symptoms, harm avoidance, and a history of major depressive disorder: A cohort study of pregnant women in japan. Frontiers in psychiatry. 2019;10:515.
14. Matsubara T, Hayashi K, Wakatsuki K, Abe M, Ozaki N, Yamanaka A, Mizumura K, Taguchi T. Thin-fibre receptors expressing acid-sensing ion channel 3 contribute to muscular mechanical hypersensitivity after exercise. European journal of pain (London, England). 2019;23(10):1801-13.
15. Miyata S, Noda A, Kawai S, Honda K, Iwamoto K, Ozaki N, Miyazaki S, Kondo T. Delayed sleep/wake rhythm and excessive daytime sleepiness correlate with decreased daytime brain activity during cognitive task in university students. Biological and rhythm research, 2019; 50(2)：171-179.
16. Miyauchi T, Tokura T, Kimura H, Ito M, Umemura E, Sato Boku A, Nagashima W, Tonoike T, Yamamoto Y, Saito K, Kurita K, Ozaki N. Effect of antidepressant treatment on plasma levels of neuroinflammation-associated molecules in patients with somatic symptom disorder with predominant pain around the orofacial region. Human psychopharmacology. 2019;34(4):e2698.
17. Mizutani R, Saiga R, Takeuchi A, Uesugi K, Terada Y, Suzuki Y, De Andrade V, De Carlo F, Takekoshi S, Inomoto C, Nakamura N, Kushima I, Iritani S, Ozaki N, Ide S, Ikeda K, Oshima K, Itokawa M, Arai M. Three-dimensional alteration of neurites in schizophrenia. Translational psychiatry. 2019;9(1):85.
18. Nakamura Y, Nakatochi M, Kunimoto S, Okada T, Aleksic B, Toyama M, Shiino T, Morikawa M, Yamauchi A, Yoshimi A, Furukawa-Hibi Y, Nagai T, Ohara M, Kubota C, Yamada K, Ando M, Ozaki N. Methylation analysis for postpartum depression: A case control study. BMC psychiatry. 2019;19(1):190.
19. Noda A, Yasuma F, Miyata S, Iwamoto K, Yasuda Y, Ozaki N. Sleep fragmentation and risk of automobile accidents in patients with obstructive sleep apnea. Health 2019; 11(2): 171-181.
20. Owada K, Okada T, Munesue T, Kuroda M, Fujioka T, Uno Y, Matsumoto K, Kuwabara H, Mori D, Okamoto Y, Yoshimura Y, Kawakubo Y, Arioka Y, Kojima M, Yuhi T, Yassin W, Kushima I, Benner S, Ogawa N, Kawano N, Eriguchi Y, Uemura Y, Yamamoto M, Kano Y, Kasai K, Higashida H, Ozaki N, Kosaka H, Yamasue H. Quantitative facial expression analysis revealed the efficacy and time course of oxytocin in autism. Brain : a journal of neurology. 2019;142(7):2127-36.
21. Park SC, Oh HS, Tripathi A, Kallivayalil RA, Avasthi A, Grover S, Tanra AJ, Kanba S, Kato TA, Inada T, Chee KY, Chong MY, Lin SK, Sim K, Xiang YT, Tan CH, Javed A, Sartorius N, Shinfuku N, Park YC. Cannabis use correlates with aggressive behavior and long-acting injectable antipsychotic treatment in asian patients with schizophrenia. Nordic journal of psychiatry. 2019;73(6):323-30.
22. Sato N, Kimura H, Adachi Y, Nishio N, Ando M, Tokura T, Nagashima W, Kishi S, Yamauchi A, Yoshida K, Hiramatsu M, Fujimoto Y, Ozaki N. Exploration of coping styles in male patients with head and neck cancer: A prospective cohort study. Nagoya journal of medical science. 2019;81(2):249-58.
23. Shishido E, Ogawa S, Miyata S, Yamamoto M, Inada T, Ozaki N. Application of eye trackers for understanding mental disorders: Cases for schizophrenia and autism spectrum disorder. Neuropsychopharmacology reports. 2019;39(2):72-7.
24. Takeuchi S, Hida H, Uchida M, Naruse R, Yoshimi A, Kitagaki S, Ozaki N, Noda Y. Blonanserin ameliorates social deficit through dopamine-d3 receptor antagonism in mice administered phencyclidine as an animal model of schizophrenia. Neurochemistry international. 2019;128:127-34.
25. Tanaka S, Oya-Ito T, Murakami Y, Saito K, Furuta S, Yu Y, Imaeda M, Kunimoto S, Ozaki N. Decline of plasma concentrations of interleukin-18 in severely malnourished patients with anorexia nervosa: Exploratory analysis. Nutrients. 2019;11(3).
26. Teshigawara T, Mouri A, Kubo H, Nakamura Y, Shiino T, Okada T, Morikawa M, Nabeshima T, Ozaki N, Yamamoto Y, Saito K. Changes in tryptophan metabolism during pregnancy and postpartum periods: Potential involvement in postpartum depressive symptoms. Journal of affective disorders. 2019;255:168-76.
27. Uchida M, Hida H, Mori K, Yoshimi A, Kitagaki S, Yamada K, Hiraoka Y, Aida T, Tanaka K, Ozaki N, Noda Y. Erratum to \"functional roles of the glial glutamate transporter (glast) in emotional and cognitive abnormalities of mice after repeated phencyclidine administration\" [european neuropsychopharmacology (2019) 29, 914-924]. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. 2019;29(9):1063-4.
28. Uchida M, Hida H, Mori K, Yoshimi A, Kitagaki S, Yamada K, Hiraoka Y, Aida T, Tanaka K, Ozaki N, Noda Y. Functional roles of the glial glutamate transporter (glast) in emotional and cognitive abnormalities of mice after repeated phencyclidine administration. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. 2019;29(8):914-24.
29. Ueda K, Kiyota A, Tsuchida M, Okazaki M, Ozaki N. Successful treatment of myxedema coma with a combination of levothyroxine and liothyronine. Endocrine journal. 2019;66(5):469-74.
30. Umemura E, Tokura T, Ito M, Kobayashi Y, Tachibana M, Miyauchi T, Tonoike T, Nagashima W, Kimura H, Arao M, Sato Boku A, Ozaki N, Kurita K. Oral medicine psychiatric liaison clinic: Study of 1202 patients attending over an 18-year period. International journal of oral and maxillofacial surgery. 2019;48(5):644-50.
31. Weidle B, Chaulagain A, Stensen K, Aleksic B, Skokauskas N, Inada T. Drug-induced extrapyramidal symptoms scale of the norwegian version: Inter-rater and test-retest reliability. Nordic journal of psychiatry. 2019;73(8):546-50.
32. Yoshimi A, Yamada S, Kunimoto S, Aleksic B, Hirakawa A, Ohashi M, Matsumoto Y, Hada K, Itoh N, Arioka Y, Kimura H, Kushima I, Nakamura Y, Shiino T, Mori D, Tanaka S, Hamada S, Noda Y, Nagai T, Yamada K, Ozaki N. Author correction: Proteomic analysis of lymphoblastoid cell lines from schizophrenic patients. Translational psychiatry. 2019;9(1):146.
33. Yoshimi A, Yamada S, Kunimoto S, Aleksic B, Hirakawa A, Ohashi M, Matsumoto Y, Hada K, Itoh N, Arioka Y, Kimura H, Kushima I, Nakamura Y, Shiino T, Mori D, Tanaka S, Hamada S, Noda Y, Nagai T, Yamada K, Ozaki N. Proteomic analysis of lymphoblastoid cell lines from schizophrenic patients. Translational psychiatry. 2019;9(1):126.
34. Arioka Y, Hirata A, Kushima I, Aleksic B, Mori D, Ozaki N. Characterization of a schizophrenia patient with a rare reln deletion by combining genomic and patient-derived cell analyses. Schizophrenia research. 2019. In press.
35. Miyata S, Otake H, Ando M, Okuda M, Fujishiro H, Iwamoto K, Noda A, Sone M, Ozaki N. Patient characteristics affecting accurate detection of sleep apnea using a bed sheet-type portable monitor. Sleep & breathing. 2019. In Press.
36. Mukoyama N, Nishio N, Kimura H, Kishi S, Tokura T, Kimura H, Hiramatsu M, Maruo T, Tsuzuki H, Fujii M, Iwami K, Takanari K, Kamei Y, Ozaki N, Sone M, Fujimoto Y. Prospective evaluation of health-related quality of life in patients undergoing anterolateral craniofacial resection with orbital exenteration. Journal of Neurological Surgery Part B, 2019. In Press.
～2018年
1. Amare AT, Schubert KO, Hou L, Clark SR, Papiol S, Heilbronner U, Degenhardt F, Tekola-Ayele F, Hsu YH, Shekhtman T, Adli M, Akula N, Akiyama K, Ardau R, Arias B, Aubry JM, Backlund L, Bhattacharjee AK, Bellivier F, Benabarre A, Bengesser S, Biernacka JM, Birner A, Brichant-Petitjean C, Cervantes P, Chen HC, Chillotti C, Cichon S, Cruceanu C, Czerski PM, Dalkner N, Dayer A, Del Zompo M, DePaulo JR, Etain B, Falkai P, Forstner AJ, Frisen L, Frye MA, Fullerton JM, Gard S, Garnham JS, Goes FS, Grigoroiu-Serbanescu M, Grof P, Hashimoto R, Hauser J, Herms S, Hoffmann P, Hofmann A, Jamain S, Jimenez E, Kahn JP, Kassem L, Kuo PH, Kato T, Kelsoe J, Kittel-Schneider S, Kliwicki S, Konig B, Kusumi I, Laje G, Landen M, Lavebratt C, Leboyer M, Leckband SG, Tortorella A, Manchia M, Martinsson L, McCarthy MJ, McElroy S, Colom F, Mitjans M, Mondimore FM, Monteleone P, Nievergelt CM, Nothen MM, Novak T, O'Donovan C, Ozaki N, Osby U, Pfennig A, Potash JB, Reif A, Reininghaus E, Rouleau GA, Rybakowski JK, Schalling M, Schofield PR, Schweizer BW, Severino G, Shilling PD, Shimoda K, Simhandl C, Slaney CM, Squassina A, Stamm T, Stopkova P, Maj M, Turecki G, Vieta E, Volkert J, Witt S, Wright A, Zandi PP, Mitchell PB, Bauer M, Alda M, Rietschel M, McMahon FJ, Schulze TG, Baune BT. Association of polygenic score for schizophrenia and hla antigen and inflammation genes with response to lithium in bipolar affective disorder: A genome-wide association study. JAMA psychiatry. 2018;75(1):65-74.
2. Arioka Y, Kushima I, Kubo H, Mori D, Ozaki N. Induced pluripotent stem cells derived from a schizophrenia patient with astn2 deletion. Stem cell research. 2018;30:81-4.
3. Arioka Y, Kushima I, Mori D, Ozaki N. Three lines of induced pluripotent stem cells derived from a 15q11.2-q13.1 duplication syndrome patient. Stem cell research. 2018;31:240-3.
4. Arioka Y, Shishido E, Kubo H, Kushima I, Yoshimi A, Kimura H, Ishizuka K, Aleksic B, Maeda T, Ishikawa M, Kuzumaki N, Okano H, Mori D, Ozaki N. Single-cell trajectory analysis of human homogenous neurons carrying a rare reln variant. Translational psychiatry. 2018;8(1):129.
5. Bagarinao E, Watanabe H, Maesawa S, Mori D, Hara K, Kawabata K, Yoneyama N, Ohdake R, Imai K, Masuda M, Yokoi T, Ogura A, Wakabayashi T, Kuzuya M, Ozaki N, Hoshiyama M, Isoda H, Naganawa S, Sobue G. An unbiased data-driven age-related structural brain parcellation for the identification of intrinsic brain volume changes over the adult lifespan. NeuroImage. 2018;169:134-44.
6. Fujishiro H, Okuda M, Iwamoto K, Miyata S, Torii Y, Iritani S, Ozaki N. Early diagnosis of lewy body disease in patients with late-onset psychiatric disorders using clinical history of rapid eye movement sleep behavior disorder and [(123) i]-metaiodobenzylguanidine cardiac scintigraphy. Psychiatry and clinical neurosciences. 2018;72(6):423-34.
7. Hasegawa S, Miyake Y, Yoshimi A, Mouri A, Hida H, Yamada K, Ozaki N, Nabeshima T, Noda Y. Dysfunction of serotonergic and dopaminergic neuronal systems in the antidepressant-resistant impairment of social behaviors induced by social defeat stress exposure as juveniles. The international journal of neuropsychopharmacology. 2018;21(9):837-46.
8. Ikeda M, Takahashi A, Kamatani Y, Momozawa Y, Saito T, Kondo K, Shimasaki A, Kawase K, Sakusabe T, Iwayama Y, Toyota T, Wakuda T, Kikuchi M, Kanahara N, Yamamori H, Yasuda Y, Watanabe Y, Hoya S, Aleksic B, Kushima I, Arai H, Takaki M, Hattori K, Kunugi H, Okahisa Y, Ohnuma T, Ozaki N, Someya T, Hashimoto R, Yoshikawa T, Kubo M, Iwata N. Genome-wide association study detected novel susceptibility genes for schizophrenia and shared trans-populations/diseases genetic effect. Schizophrenia bulletin. 2018.
9. Ikeda M, Tanaka S, Saito T, Ozaki N, Kamatani Y, Iwata N. Re-evaluating classical body type theories: Genetic correlation between psychiatric disorders and body mass index. Psychological medicine. 2018;48(10):1745-8.
10. Iritani S, Habuchi C, Sekiguchi H, Torii Y. Brain research and clinical psychiatry: Establishment of a psychiatry brain bank in japan. Nagoya journal of medical science. 2018;80(3):309-15.
11. Iritani S, Torii Y, Habuchi C, Sekiguchi H, Fujishiro H, Yoshida M, Go Y, Iriki A, Isoda M, Ozaki N. The neuropathological investigation of the brain in a monkey model of autism spectrum disorder with abca13 deletion. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. 2018;71:130-9.
12. Ishizuka K, Kimura H, Kushima I, Inada T, Okahisa Y, Ikeda M, Iwata N, Mori D, Aleksic B, Ozaki N. Assessment of a glyoxalase i frameshift variant, p.P122fs, in japanese patients with schizophrenia. Psychiatric genetics. 2018;28(5):90-3.
13. Ishizuka K, Tabata H, Ito H, Kushima I, Noda M, Yoshimi A, Usami M, Watanabe K, Morikawa M, Uno Y, Okada T, Mori D, Aleksic B, Ozaki N, Nagata KI. Possible involvement of a cell adhesion molecule, migfilin, in brain development and pathogenesis of autism spectrum disorders. Journal of neuroscience research. 2018;96(5):789-802.
14. Iwata M, Iwamoto K, Kawano N, Kawaue T, Ozaki N. Evaluation method regarding the effect of psychotropic drugs on driving performance: A literature review. Psychiatry and clinical neurosciences. 2018;72(10):747-73.
15. Kato K, Iwamoto K, Kawano N, Noda Y, Ozaki N, Noda A. Differential effects of physical activity and sleep duration on cognitive function in young adults. Journal of sport and health science. 2018;7(2):227-36.
16. Kimura H, Kushima I, Yohimi A, Aleksic B, Ozaki N. Copy number variant in the region of adenosine kinase (adk) and its possible contribution to schizophrenia susceptibility. The international journal of neuropsychopharmacology. 2018;21(5):405-9.
17. Kubota C, Inada T, Nakamura Y, Shiino T, Ando M, Aleksic B, Yamauchi A, Morikawa M, Okada T, Ohara M, Sato M, Murase S, Goto S, Kanai A, Ozaki N. Stable factor structure of the edinburgh postnatal depression scale during the whole peripartum period: Results from a japanese prospective cohort study. Scientific reports. 2018;8(1):17659.
18. Kubota C, Okada T, Morikawa M, Nakamura Y, Yamauchi A, Ando M, Shiino T, Ohara M, Murase S, Goto S, Kanai A, Masuda T, Aleksic B, Ozaki N. Postpartum depression among women in nagoya indirectly exposed to the great east japan earthquake. Scientific reports. 2018;8(1):11624.
19. Kunisawa K, Shimizu T, Kushima I, Aleksic B, Mori D, Osanai Y, Kobayashi K, Taylor AM, Bhat MA, Hayashi A, Baba H, Ozaki N, Ikenaka K. Dysregulation of schizophrenia-related aquaporin 3 through disruption of paranode influences neuronal viability. Journal of neurochemistry. 2018;147(3):395-408.
20. Kushima I, Aleksic B, Nakatochi M, Shimamura T, Okada T, Uno Y, Morikawa M, Ishizuka K, Shiino T, Kimura H, Arioka Y, Yoshimi A, Takasaki Y, Yu Y, Nakamura Y, Yamamoto M, Iidaka T, Iritani S, Inada T, Ogawa N, Shishido E, Torii Y, Kawano N, Omura Y, Yoshikawa T, Uchiyama T, Yamamoto T, Ikeda M, Hashimoto R, Yamamori H, Yasuda Y, Someya T, Watanabe Y, Egawa J, Nunokawa A, Itokawa M, Arai M, Miyashita M, Kobori A, Suzuki M, Takahashi T, Usami M, Kodaira M, Watanabe K, Sasaki T, Kuwabara H, Tochigi M, Nishimura F, Yamasue H, Eriguchi Y, Benner S, Kojima M, Yassin W, Munesue T, Yokoyama S, Kimura R, Funabiki Y, Kosaka H, Ishitobi M, Ohmori T, Numata S, Yoshikawa T, Toyota T, Yamakawa K, Suzuki T, Inoue Y, Nakaoka K, Goto YI, Inagaki M, Hashimoto N, Kusumi I, Son S, Murai T, Ikegame T, Okada N, Kasai K, Kunimoto S, Mori D, Iwata N, Ozaki N. Comparative analyses of copy-number variation in autism spectrum disorder and schizophrenia reveal etiological overlap and biological insights. Cell reports. 2018;24(11):2838-56.
21. Marui T, Torii Y, Iritani S, Sekiguchi H, Habuchi C, Fujishiro H, Oshima K, Niizato K, Hayashida S, Masaki K, Kira J, Ozaki N. The neuropathological study of myelin oligodendrocyte glycoprotein in the temporal lobe of schizophrenia patients. Acta neuropsychiatrica. 2018;30(4):232-40.
22. Miyata A, Iwamoto K, Kawano N, Aleksic B, Ando M, Ebe K, Fujita K, Yokoyama M, Akiyama T, Igarashi Y, Ozaki N. Driving performance of stable outpatients with depression undergoing real-world treatment. Psychiatry and clinical neurosciences. 2018;72(6):399-408.
23. Morita K, Miura K, Fujimoto M, Shishido E, Shiino T, Takahashi J, Yamamori H, Yasuda Y, Kudo N, Hirano Y, Koshiyama D, Okada N, Ikeda M, Onitsuka T, Ozaki N, Kasai K, Hashimoto R. Abnormalities of eye movement are associated with work hours in schizophrenia. Schizophrenia research. 2018;202:420-2.
24. Mouri A, Ukai M, Uchida M, Hasegawa S, Taniguchi M, Ito T, Hida H, Yoshimi A, Yamada K, Kunimoto S, Ozaki N, Nabeshima T, Noda Y. Juvenile social defeat stress exposure persistently impairs social behaviors and neurogenesis. Neuropharmacology. 2018;133:23-37.
25. Nakagawa T, Hiraga SI, Mizumura K, Hori K, Ozaki N, Koeda T. Topical thermal therapy with hot packs suppresses physical inactivity-induced mechanical hyperalgesia and up-regulation of ngf. The journal of physiological sciences : JPS. 2018;68(5):629-37.
26. Ogasawara K, Nakamura Y, Kimura H, Aleksic B, Ozaki N. Issues on the diagnosis and etiopathogenesis of mood disorders: Reconsidering dsm-5. Journal of neural transmission (Vienna, Austria : 1996). 2018;125(2):211-22.
27. Ohara M, Nakatochi M, Okada T, Aleksic B, Nakamura Y, Shiino T, Yamauchi A, Kubota C, Morikawa M, Murase S, Goto S, Kanai A, Kato R, Ando M, Ozaki N. Impact of perceived rearing and social support on bonding failure and depression among mothers: A longitudinal study of pregnant women. Journal of psychiatric research. 2018;105:71-7.
28. Ozaki N. Right treatment for the right schizophrenic patients based on carbonyl stress pathophysiology. Psychiatry and clinical neurosciences. 2018;72(1):2.
29. Reinbold CS, Forstner AJ, Hecker J, Fullerton JM, Hoffmann P, Hou L, Heilbronner U, Degenhardt F, Adli M, Akiyama K, Akula N, Ardau R, Arias B, Backlund L, Benabarre A, Bengesser S, Bhattacharjee AK, Biernacka JM, Birner A, Marie-Claire C, Cervantes P, Chen GB, Chen HC, Chillotti C, Clark SR, Colom F, Cousins DA, Cruceanu C, Czerski PM, Dayer A, Etain B, Falkai P, Frisen L, Gard S, Garnham JS, Goes FS, Grof P, Gruber O, Hashimoto R, Hauser J, Herms S, Jamain S, Jimenez E, Kahn JP, Kassem L, Kittel-Schneider S, Kliwicki S, Konig B, Kusumi I, Lackner N, Laje G, Landen M, Lavebratt C, Leboyer M, Leckband SG, Lopez Jaramillo CA, MacQueen G, Manchia M, Martinsson L, Mattheisen M, McCarthy MJ, McElroy SL, Mitjans M, Mondimore FM, Monteleone P, Nievergelt CM, Osby U, Ozaki N, Perlis RH, Pfennig A, Reich-Erkelenz D, Rouleau GA, Schofield PR, Schubert KO, Schweizer BW, Seemuller F, Severino G, Shekhtman T, Shilling PD, Shimoda K, Simhandl C, Slaney CM, Smoller JW, Squassina A, Stamm TJ, Stopkova P, Tighe SK, Tortorella A, Turecki G, Volkert J, Witt SH, Wright AJ, Young LT, Zandi PP, Potash JB, DePaulo JR, Bauer M, Reininghaus E, Novak T, Aubry JM, Maj M, Baune BT, Mitchell PB, Vieta E, Frye MA, Rybakowski JK, Kuo PH, Kato T, Grigoroiu-Serbanescu M, Reif A, Del Zompo M, Bellivier F, Schalling M, Wray NR, Kelsoe JR, Alda M, McMahon FJ, Schulze TG, Rietschel M, Nothen MM, Cichon S. Analysis of the influence of micrornas in lithium response in bipolar disorder. Frontiers in psychiatry. 2018;9:207.
30. Sobue A, Kushima I, Nagai T, Shan W, Kohno T, Aleksic B, Aoyama Y, Mori D, Arioka Y, Kawano N, Yamamoto M, Hattori M, Nabeshima T, Yamada K, Ozaki N. Genetic and animal model analyses reveal the pathogenic role of a novel deletion of reln in schizophrenia. Scientific reports. 2018;8(1):13046.
31. Takata A, Miyake N, Tsurusaki Y, Fukai R, Miyatake S, Koshimizu E, Kushima I, Okada T, Morikawa M, Uno Y, Ishizuka K, Nakamura K, Tsujii M, Yoshikawa T, Toyota T, Okamoto N, Hiraki Y, Hashimoto R, Yasuda Y, Saitoh S, Ohashi K, Sakai Y, Ohga S, Hara T, Kato M, Nakamura K, Ito A, Seiwa C, Shirahata E, Osaka H, Matsumoto A, Takeshita S, Tohyama J, Saikusa T, Matsuishi T, Nakamura T, Tsuboi T, Kato T, Suzuki T, Saitsu H, Nakashima M, Mizuguchi T, Tanaka F, Mori N, Ozaki N, Matsumoto N. Integrative analyses of de novo mutations provide deeper biological insights into autism spectrum disorder. Cell reports. 2018;22(3):734-47.
32. Tsuruta Y, Iwamoto K, Banno M, Kawano N, Kohmura K, Miyata S, Fujishiro H, Noda Y, Noda A, Iritani S, Ozaki N. Effects of hypnotics on prefrontal cortex activity during a verbal fluency task in healthy male subjects: A near-infrared spectroscopy study. Human psychopharmacology. 2018;33(6):e2678.
33. Yamamoto M, Kushima I, Suzuki R, Branko A, Kawano N, Inada T, Iidaka T, Ozaki N. Aberrant functional connectivity between the thalamus and visual cortex is related to attentional impairment in schizophrenia. Psychiatry research Neuroimaging. 2018;278:35-41.
34. Yamasue H, Okada T, Munesue T, Kuroda M, Fujioka T, Uno Y, Matsumoto K, Kuwabara H, Mori D, Okamoto Y, Yoshimura Y, Kawakubo Y, Arioka Y, Kojima M, Yuhi T, Owada K, Yassin W, Kushima I, Benner S, Ogawa N, Eriguchi Y, Kawano N, Uemura Y, Yamamoto M, Kano Y, Kasai K, Higashida H, Ozaki N, Kosaka H. Effect of intranasal oxytocin on the core social symptoms of autism spectrum disorder: A randomized clinical trial. Molecular psychiatry. 2018.
35. Yamauchi A, Okada T, Ando M, Morikawa M, Nakamura Y, Kubota C, Ohara M, Murase S, Goto S, Kanai A, Ozaki N. Validation and factor analysis of the japanese version of the highs scale in perinatal women. Frontiers in psychiatry. 2018;9:269.
36. Yu Y, Lin Y, Takasaki Y, Wang C, Kimura H, Xing J, Ishizuka K, Toyama M, Kushima I, Mori D, Arioka Y, Uno Y, Shiino T, Nakamura Y, Okada T, Morikawa M, Ikeda M, Iwata N, Okahisa Y, Takaki M, Sakamoto S, Someya T, Egawa J, Usami M, Kodaira M, Yoshimi A, Oya-Ito T, Aleksic B, Ohno K, Ozaki N. Rare loss of function mutations in n-methyl-d-aspartate glutamate receptors and their contributions to schizophrenia susceptibility. Translational psychiatry. 2018;8(1):12.
37. Yukawa T, Iwakura Y, Takei N, Saito M, Watanabe Y, Toyooka K, Igarashi M, Niizato K, Oshima K, Kunii Y, Yabe H, Matsumoto J, Wada A, Hino M, Iritani S, Niwa SI, Takeuchi R, Takahashi H, Kakita A, Someya T, Nawa H. Pathological alterations of chondroitin sulfate moiety in postmortem hippocampus of patients with schizophrenia. Psychiatry research. 2018;270:940-6.
38. Aleksic B, Ozaki N. Schizophrenia polygenic risk score and prepubertal developmental impairments. Lancet Psychiatry. 2017;4(1):7-8.
39. Iwamoto K, Fujishiro H, Ozaki N. Effect of aripiprazole augmentation for depressive symptoms changes with progression of lewy body disease. Psychiatry Clin Neurosci. 2017;71(1):74-75.
40. Kato K, Miyata S, Ando M, Matsuoka H, Yasuma F, Iwamoto K, Kawano N, Banno M, Ozaki N, Noda A. Influence of sleep duration on cortical oxygenation in elderly individuals. Psychiatry Clin Neurosci. 2017;71(1):44-51.
41. Munechika T, Fujishiro H, Okuda M, Iwamoto K, Torii Y, Iritani S, Ozaki N. Rapid eye movement sleep without atonia may help diagnose lewy body disease in middle-aged and older patients with somatic symptom disorder. Psychogeriatrics. 2017;17(1):61-69.
42. Ohara M, Okada T, Aleksic B, Morikawa M, Kubota C, Nakamura Y, Shiino T, Yamauchi A, Uno Y, Murase S, Goto S, Kanai A, Masuda T, Nakatochi M, Ando M, Ozaki N. Social support helps protect against perinatal bonding failure and depression among mothers: A prospective cohort study. Sci Rep. 2017;7(1):9546.
43. Saito T, Ikeda M, Hashimoto R, Iwata N, Yamamori H, Yasuda Y, Fujimoto M, Kondo K, Shimasaki A, Kawase K, Miyata M, Mushiroda T, Ozeki T, Kubo M, Fujita K, Kida N, Nakai M, Otsuru T, Fukuji Y, Murakami M, Mizuno K, Shiratsuchi T, Numata S, Ohmori T, Ueno S I, Yada Y, Tanaka S, Kishi Y, Takaki M, Mamoto A, Taniguchi N, Sawa Y, Watanabe H, Noda T, Amano Y, Kimura T, Fukao T, Suwa T, Murai T, Kubota M, Ueda K, Tabuse H, Kanahara N, Kawai N, Nemoto K, Makinodan M, Nishihata Y, Hashimoto N, Kusumi I, Fujii Y, Miyata R, Hirakawa K, Ozaki N. Transethnic replication study to assess the association between clozapine-induced agranulocytosis/granulocytopenia and genes at 12p12.2 in a Japanese population. Biol Psychiatry. 2017;82(1):e9-e10.
44. Sekiguchi H, Moriwaki M, Iritani S, Habuchi C, Torii Y, Umeda K, Fujishiro H, Yoshida M, Fujita K. An autopsy case of dementia with Lewy bodies clinically diagnosed to have a behavioral variant of frontotemporal dementia. Clin Neuropathol. 2017;36 (2017)(1):23-30.
45. Fujioi J, Iwamoto K, Banno M, Kikuchi T, Aleksic B, Ozaki N. Effect of adjunctive aripiprazole on sexual dysfunction in schizophrenia: A preliminary open-label study. Pharmacopsychiatry. 2017;50(2):74-78.
46. Ukai K, Fujishiro H, Ozaki N. Effectiveness of low-dose pregabalin in three patients with lewy body disease and central neuropathic pain. Psychogeriatrics. 2017;17(2):115-119.
47. Ukai K, Fujishiro H, Watanabe M, Kosaka K, Ozaki N. Similarity of symptoms between transient epileptic amnesia and lewy body disease. Psychogeriatrics. 2017;17(2):120-125.
48. Ogasawara K, Nakamura Y, Kimura H, Aleksic B, Ozaki N. Issues on the diagnosis and etiopathogenesis of mood disorders: reconsidering DSM-5. J Neural Transm. 2017;125(2):211-222.
49. Kushima I, Aleksic B, Nakatochi M, Shimamura T, Shiino T, Yoshimi A, Kimura H, Takasaki Y, Wang C, Xing J, Ishizuka K, Oya-Ito T, Nakamura Y, Arioka Y, Maeda T, Yamamoto M, Yoshida M, Noma H, Hamada S, Morikawa M, Uno Y, Okada T, Iidaka T, Iritani S, Yamamoto T, Miyashita M, Kobori A, Arai M, Itokawa M, Cheng M C, Chuang Y A, Chen C H, Suzuki M, Takahashi T, Hashimoto R, Yamamori H, Yasuda Y, Watanabe Y, Nunokawa A, Someya T, Ikeda M, Toyota T, Yoshikawa T, Numata S, Ohmori T, Kunimoto S, Mori D, Iwata N, Ozaki N. High-resolution copy number variation analysis of schizophrenia in Japan. Mol Psychiatry. 2017;22(3):430-440.
50. Fujishiro H, Okuda M, Iwamoto K, Miyata S, Otake H, Noda A, Iritani S, Ozaki N. Rem sleep without atonia in middle-aged and older psychiatric patients and lewy body disease: A case series. Int J Geriatr Psychiatry. 2017;32(4):397-406.
51. Kobayashi Y, Nagashima W, Tokura T, Yoshida K, Umemura E, Miyauchi T, Arao M, Ito M, Kimura H, Kurita K, Ozaki N. Duloxetine plasma concentrations and its effectiveness in the treatment of nonorganic chronic pain in the orofacial region. Clin Neuropharmacol. 2017;40(4):163-168.
52. Fujino H, Sumiyoshi C, Yasuda Y, Yamamori H, Fujimoto M, Fukunaga M, Miura K, Takebayashi Y, Okada N, Isomura S, Kawano N, Toyomaki A, Kuga H, Isobe M, Oya K, Okahisa Y, Takaki M, Hashimoto N, Kato M, Onitsuka T, Ueno T, Ohnuma T, Kasai K, Ozaki N, Sumiyoshi T, Imura O, Hashimoto R, Cocoro. Estimated cognitive decline in patients with schizophrenia: A multicenter study. Psychiatry Clin Neurosci. 2017;71(5):294-300.
53. Sekiguchi H, Iritani S, Fujita K. Bright light therapy for sleep disturbance in dementia is most effective for mild to moderate Alzheimer's type dementia: a case series. Psychogeriatrics. 2017;17(5):275-281.
54. Onishi Y, Kimura H, Hori T, Kishi S, Kamei H, Kurata N, Tsuboi C, Yamaguchi N, Takahashi M, Sunada S, Hirano M, Fujishiro H, Okada T, Ishigami M, Goto H, Ozaki N, Ogura Y. Risk of alcohol use relapse after liver transplantation for alcoholic liver disease. World J Gastroenterol. 2017;23(5):869-875.
55. Goto A, Yoshimi A, Nagai T, Ukigai M, Mouri A, Ozaki N, Noda Y. Human neutrophils show decreased survival upon long-term exposure to clozapine. Hum Psychopharmacol Clin Exp. 2017;32(6):e2629.
56. Sumiyoshi T, Toyomaki A, Kawano N, Kitajima T, Kusumi I, Ozaki N, Iwata N, Nakagome K. Reliability and validity of the california verbal learning test-ii - Japanese version. Psychiatry Clin Neurosci. 2017;71(6):417-418.
57. Sumiyoshi T, Toyomaki A, Kawano N, Kitajima T, Kusumi I, Ozaki N, Iwata N, Sueyoshi K, Nakagome K. Verbal memory impairments in bipolar disorder: Effect of type of word learning tasks. Psychiatry Clin Neurosci. 2017;71(8):570-571.
58. Ishizuka K, Fujita Y, Kawabata T, Kimura H, Iwayama Y, Inada T, Okahisa Y, Egawa J, Usami M, Kushima I, Uno Y, Okada T, Ikeda M, Aleksic B, Mori D, Someya T, Yoshikawa T, Iwata N, Nakamura H, Yamashita T, Ozaki N. Rare genetic variants in cx3cr1 and their contribution to the increased risk of schizophrenia and autism spectrum disorders. Transl Psychiatry. 2017;7(8):e1184.
59. Kasahara T, Ishiwata M, Kakiuchi C, Fuke S, Iwata N, Ozaki N, Kunugi H, Minabe Y, Nakamura K, Iwata Y, Fujii K, Kanba S, Ujike H, Kusumi I, Kataoka M, Matoba N, Takata A, Iwamoto K, Yoshikawa T, Kato T. Enrichment of deleterious variants of mitochondrial DNA polymerase gene (polg1) in bipolar disorder. Psychiatry Clin Neurosci. 2017;71(8):518-529.
60. Kimura H, Fujita Y, Kawabata T, Ishizuka K, Wang C, Iwayama Y, Okahisa Y, Kushima I, Morikawa M, Uno Y, Okada T, Ikeda M, Inada T, Branko A, Mori D, Yoshikawa T, Iwata N, Nakamura H, Yamashita T, Ozaki N. A novel rare variant r292h in rtn4r affects growth cone formation and possibly contributes to schizophrenia susceptibility. Transl Psychiatry. 2017;7(8):e1214.
61. Hill R S, Goldberg A P, Poultney C, Minshew N J, Kushima I, Aleksic B, Ozaki N, Parellada M, Arango C, Penzol M J, Carracedo A, Kolevzon A, Hultman C M, Weiss L A, Fromer M, Chiocchetti A G, Freitag C M, Church G M, Scherer S W, Buxbaum J D, Walsh C A. Rates, distribution and implications of postzygotic mosaic mutations in autism spectrum disorder. Nat Neurosci. 2017;20(9):1217-1224.
62. Ohara M, Okada T, Kubota C, Nakamura Y, Shiino T, Aleksic B, Morikawa M, Yamauchi A, Uno Y, Murase S, Goto S, Kanai A, Masuda T, Ando M, Ozaki N. Relationship between maternal depression and bonding failure: A prospective cohort study of pregnant women. Psychiatry Clin Neurosci. 2017;71(10):733-741.
63. Matsumoto Y, Niwa M, Mouri A, Noda Y, Fukushima T, Ozaki N, Nabeshima T. Adolescent stress leads to glutamatergic disturbance through dopaminergic abnormalities in the prefrontal cortex of genetically vulnerable mice. Psychopharmacology. 2017;234(20):3055-3074.
64. Kimura H, Kushima I, Yohimi A, Aleksic B, Ozaki N. Copy number variant in the region of adenosine kinase (adk) and its possible contribution to schizophrenia susceptibility. Int J Neuropsychopharmacol. 2017　 pyx103, https://doi.org/10.1093/ijnp/pyx103.
65. Kimura H, Onishi Y, Kishi S, Kurata N, Ogiso S, Kamei H, Tsuboi C, Yamaguchi N, Shiga A, Kondo M, Yokoyama Y, Takasato F, Fujishiro H, Ishizuka K, Okada T, Ogura Y, Ozaki N. Successful post-transplant psychiatric interventions during long-term follow-up of patients receiving liver transplants for alcoholic liver disease. Am J Case Rep. 2017;18:1215-1219.
66. Kohmura K, Adachi Y, Tanaka S, Katayama H, Imaeda M, Kawano N, Nishioka K, Ando M, Iidaka T, Ozaki N. Regional decrease in gray matter volume is related to body dissatisfaction in anorexia nervosa. Psychiatry Res Neuroimaging. 2017;267:51-58.
67. Morosawa S, Iritani S, Fujishiro H, Sekiguchi H, Torii Y, Habuchi C, Kuroda K, Kaibuchi K, Ozaki N. Neuropeptide y neuronal network dysfunction in the frontal lobe of a genetic mouse model of schizophrenia. Neuropeptides. 2017;62:27-35.
68. Sumiyoshi T, Toyomaki A, Kawano N, Kitajima T, Kusumi I, Ozaki N, Iwata N, Sueyoshi K, Nakagome K. Verbal memory impairment in patients with subsyndromal bipolar disorder. Front Psychiatry. 2017;8:168.
69. Umeda K, Iritani S, Fujishiro H, Sekiguchi H, Torii Y, Habuchi C, Kuroda K, Kaibuchi K, Ozaki N. Immunohistochemical Evaluation of the GABAergic Neuronal System in the Prefrontal Cortex of a DISC1 Knockout Mouse Model of Schizophrenia. Synapse, in press.
70. Ukai K, Fujishiro H, Watanabe M, Kosaka K, Ozaki N. Similarity of symptoms between transient epileptic amnesia and Lewy body disease. Psychogeriatrics, in press.
71. Ukai K, Fujishiro H, Ozaki N. Effectiveness of low-dose pregabalin in three patients with Lewy body disease and central neuropathic pain. Psychogeriatrics, in press.
72. Ukai K, Fujishiro H, Iritani S, Ozaki N. Long-term efficacy of donepezil for relapse of visual hallucinations in patients with dementia with Lewy bodies. Psychogeriatrics, in press.
73. Torii Y, Iritani S, Fujishiro H, Sekiguchi H, Habuchi C, Umeda K, Matsunaga S, Mimuro M, Ozaki N, Yoshida M, Fujita K. An autopsy case of cortical superficial siderosis with persistent abnormal behavior. Neuropathology, in press.
74. Sekiguchi H, Moriwaki M, Iritani S, Habuchi C, Torii Y, Umeda K, Fujishiro H, Yoshida M, Fujita K. An autopsy case of dementia with Lewy bodies clinically diagnosed to have a behavioral variant of frontotemporal dementia. Clin Neuropathol, in press.
75. Okada N, Fukunaga M, Yamashita F, Koshiyama D, Yamamori H, Ohi K, Yasuda Y, Fujimoto M, Watanabe Y, Yahata N, Nemoto K, Hibar DP, van Erp TG, Fujino H, Isobe M, Isomura S, Natsubori T, Narita H, Hashimoto N, Miyata J, Koike S, Takahashi T, Yamasue H, Matsuo K, Onitsuka T, Iidaka T, Kawasaki Y, Yoshimura R, Watanabe Y, Suzuki M, Turner JA, Takeda M, Thompson PM, Ozaki N, Kasai K, Hashimoto R. Abnormal asymmetries in subcortical brain volume in schizophrenia. Mol Psychiatry, in press.
76. Munechika T, Fujishiro H, Okuda M, Iwamoto K, Torii Y, Iritani S, Ozaki N. Rapid eye movement sleep without atonia may help diagnose Lewy body disease in middle-aged and older patients with somatic symptom disorder. Psychogeriatrics, in press.
77. Miyashita M, Watanabe T, Ichikawa T, Toriumi K, Horiuchi Y, Kobori A, Kushima I, Hashimoto R, Fukumoto M, Koike S, Ujike H, Arinami T, Tatebayashi Y, Kasai K, Takeda M, Ozaki N, Okazaki Y, Yoshikawa T, Amano N, Washizuka S, Yamamoto H, Miyata T, Itokawa M, Yamamoto Y, Arai M. The regulation of soluble receptor for AGEs contributes to carbonyl stress in schizophrenia. Biochem Biophys Res Commun, in press.
78. Kushima I, Aleksic B, Nakatochi M, Shimamura T, Shiino T, Yoshimi A, Kimura H, Takasaki Y, Wang C, Xing J, Ishizuka K, Oya-Ito T, Nakamura Y, Arioka Y, Maeda T, Yamamoto M, Yoshida M, Noma H, Hamada S, Morikawa M, Uno Y, Okada T, Iidaka T, Iritani S, Yamamoto T, Miyashita M, Kobori A, Arai M, Itokawa M, Cheng MC, Chuang YA, Chen CH, Suzuki M, Takahashi T, Hashimoto R, Yamamori H, Yasuda Y, Watanabe Y, Nunokawa A, Someya T, Ikeda M, Toyota T, Yoshikawa T, Numata S, Ohmori T, Kunimoto S, Mori D, Iwata N, Ozaki N. High-resolution copy number variation analysis of schizophrenia in Japan. Mol Psychiatry, in press.
79. Kuroki T, Ishitobi M, Kamio Y, Sugihara G, Murai T, Motomura K, Ogasawara K, Kimura H, Aleksic B, Ozaki N, Nakao T, Yamada K, Yoshiuchi K, Kiriike N, Ishikawa T, Kubo C, Matsunaga C, Miyata H, Asada T, Kanba S. Current Viewpoints on DSM-5 in Japan. Psychiatry Clin Neurosci, in press.
80. Kimura H, Wang C, Ishizuka K, Xing J, Takasaki Y, Kushima I, Aleksic B, Uno Y, Okada T, Ikeda M, Mori D, Inada T, Iwata N, Ozaki N. Identification of a rare variant in CHD8 that contributes to schizophrenia and autism spectrum disorder susceptibility. Schizophr Res, in press.
81. Kato K, Miyata S, Ando M, Matsuoka H, Yasuma F, Iwamoto K, Kawano N, Banno M, Ozaki N, Noda A. Influence of sleep duration on cortical oxygenation in elderly individuals. Psychiatry Clin Neurosci, in press.
82. Fujishiro H, Okuda M, Iwamoto K, Miyata S, Otake H, Noda A, Iritani S, Ozaki N. REM sleep without atonia in middle-aged and older psychiatric patients and Lewy body disease: a case series. Int J Geriatr Psychiatry, in press.
83. Fujioi J, Iwamoto K, Banno M, Kikuchi T, Aleksic B, Ozaki N. Effect of Adjunctive Aripiprazole on Sexual Dysfunction in Schizophrenia: A Preliminary Open-Label Study. Pharmacopsychiatry, in press.
84. Yoshida K, Go Y, Kushima I, Toyoda A, Fujiyama A, Imai H, Saito N, Iriki A, Ozaki N, Isoda M. Single-neuron and genetic correlates of autistic behavior in macaque. Sci Adv, 2016; 2: e1600558.
85. Yano M, Kawano N, Tanaka S, Kohmura K, Katayama H, Nishioka K, Ozaki N. Dysfunction of response inhibition in eating disorders. J Clin Exp Neuropsychol, 2016; 38: 700-708.
86. Xing J, Kimura H, Wang C, Ishizuka K, Kushima I, Arioka Y, Yoshimi A, Nakamura Y, Shiino T, Oya-Ito T, Takasaki Y, Uno Y, Okada T, Iidaka T, Aleksic B, Mori D, Ozaki N. Resequencing and Association Analysis of Six PSD-95-Related Genes as Possible Susceptibility Genes for Schizophrenia and Autism Spectrum Disorders. Sci Rep, 2016; 6: 27491.
87. Tsujii N, Saito T, Izumoto Y, Usami M, Okada T, Negoro H, Iida J. Experiences with Patient Refusal of Off-Label Prescribing of Psychotropic Medications to Children and Adolescents in Japan. J Child Adolesc Psychopharmacol, 2016; 26: 642-645.
88. Takasaki Y, Koide T, Wang C, Kimura H, Xing J, Kushima I, Ishizuka K, Mori D, Sekiguchi M, Ikeda M, Aizawa M, Tsurumaru N, Iwayama Y, Yoshimi A, Arioka Y, Yoshida M, Noma H, Oya-Ito T, Nakamura Y, Kunimoto S, Aleksic B, Uno Y, Okada T, Ujike H, Egawa J, Kuwabara H, Someya T, Yoshikawa T, Iwata N, Ozaki N. Mutation screening of GRIN2B in schizophrenia and autism spectrum disorder in a Japanese population. Sci Rep, 2016; 6: 33311.
89. Sugimoto H, Kawashima H, Ohno E, Hayashi D, Kuwahara T, Morishima T, Kawai M, Suhara H, Takeyama T, Yamamura T, Funasaka K, Nakamura M, Miyahara R, Watanabe O, Ishigami M, Suzuki M, Kimura H, Ozaki N, Hashimoto S, Goto H, Hirooka Y. The prognostic factors and trajectory of HRQOL in patients with pancreatic cancer who received psychiatric intervention. J Gastroenterol Hepatol, 2016; 31: 685-690.
90. Ohara M, Okada T, Kubota C, Nakamura Y, Shiino T, Aleksic B, Morikawa M, Yamauchi A, Uno Y, Murase S, Goto S, Kanai A, Masuda T, Ozaki N. Validation and factor analysis of mother-infant bonding questionnaire in pregnant and postpartum women in Japan. BMC Psychiatry, 2016; 16: 212.
91. Nakazawa T, Hashimoto R, Sakoori K, Sugaya Y, Tanimura A, Hashimotodani Y, Ohi K, Yamamori H, Yasuda Y, Umeda-Yano S, Kiyama Y, Konno K, Inoue T, Yokoyama K, Inoue T, Numata S, Ohnuma T, Iwata N, Ozaki N, Hashimoto H, Watanabe M, Manabe T, Yamamoto T, Takeda M, Kano M. Corrigendum: Emerging roles of ARHGAP33 in intracellular trafficking of TrkB and pathophysiology of neuropsychiatric disorders. Nat Commun, 2016; 7: 11466.
92. Nakazawa T, Hashimoto R, Sakoori K, Sugaya Y, Tanimura A, Hashimotodani Y, Ohi K, Yamamori H, Yasuda Y, Umeda-Yano S, Kiyama Y, Konno K, Inoue T, Yokoyama K, Inoue T, Numata S, Ohnuma T, Iwata N, Ozaki N, Hashimoto H, Watanabe M, Manabe T, Yamamoto T, Takeda M, Kano M. Emerging roles of ARHGAP33 in intracellular trafficking of TrkB and pathophysiology of neuropsychiatric disorders. Nat Commun, 2016; 7: 10594.
93. Isles AR, Ingason A, Lowther C, Walters J, Gawlick M, Stober G, Rees E, Martin J, Little RB, Potter H, Georgieva L, Pizzo L, Ozaki N, Aleksic B, Kushima I, Ikeda M, Iwata N, Levinson DF, Gejman PV, Shi J, Sanders AR, Duan J, Willis J, Sisodiya S, Costain G, Werge TM, Degenhardt F, Giegling I, Rujescu D, Hreidarsson SJ, Saemundsen E, Ahn JW, Ogilvie C, Girirajan SD, Stefansson H, Stefansson K, O'Donovan MC, Owen MJ, Bassett A, Kirov G. Parental Origin of Interstitial Duplications at 15q11.2-q13.3 in Schizophrenia and Neurodevelopmental Disorders. PLoS Genet, 2016; 12: e1005993.
94. Ishizuka K, Kimura H, Wang C, Xing J, Kushima I, Arioka Y, Oya-Ito T, Uno Y, Okada T, Mori D, Aleksic B, Ozaki N. Investigation of Rare Single-Nucleotide PCDH15 Variants in Schizophrenia and Autism Spectrum Disorders. PLoS One, 2016; 11: e0153224.
95. Iritani S, Sekiguchi H, Habuchi C, Torii Y, Kuroda K, Kaibuchi K, Ozaki N. Catecholaminergic neuronal network dysfunction in the frontal lobe of a genetic mouse model of schizophrenia. Acta Neuropsychiatr, 2016; 28: 117-123.
96. Hou L, Heilbronner U, Degenhardt F, Adli M, Akiyama K, Akula N, Ardau R, Arias B, Backlund L, Banzato CE, Benabarre A, Bengesser S, Bhattacharjee AK, Biernacka JM, Birner A, Brichant-Petitjean C, Bui ET, Cervantes P, Chen GB, Chen HC, Chillotti C, Cichon S, Clark SR, Colom F, Cousins DA, Cruceanu C, Czerski PM, Dantas CR, Dayer A, Etain B, Falkai P, Forstner AJ, Frisen L, Fullerton JM, Gard S, Garnham JS, Goes FS, Grof P, Gruber O, Hashimoto R, Hauser J, Herms S, Hoffmann P, Hofmann A, Jamain S, Jimenez E, Kahn JP, Kassem L, Kittel-Schneider S, Kliwicki S, Konig B, Kusumi I, Lackner N, Laje G, Landen M, Lavebratt C, Leboyer M, Leckband SG, Jaramillo CA, MacQueen G, Manchia M, Martinsson L, Mattheisen M, McCarthy MJ, McElroy SL, Mitjans M, Mondimore FM, Monteleone P, Nievergelt CM, Nothen MM, Osby U, Ozaki N, Perlis RH, Pfennig A, Reich-Erkelenz D, Rouleau GA, Schofield PR, Schubert KO, Schweizer BW, Seemuller F, Severino G, Shekhtman T, Shilling PD, Shimoda K, Simhandl C, Slaney CM, Smoller JW, Squassina A, Stamm T, Stopkova P, Tighe SK, Tortorella A, Turecki G, Volkert J, Witt S, Wright A, Young LT, Zandi PP, Potash JB, DePaulo JR, Bauer M, Reininghaus EZ, Novak T, Aubry JM, Maj M, Baune BT, Mitchell PB, Vieta E, Frye MA, Rybakowski JK, Kuo PH, Kato T, Grigoroiu-Serbanescu M, Reif A, Del Zompo M, Bellivier F, Schalling M, Wray NR, Kelsoe JR, Alda M, Rietschel M, McMahon FJ, Schulze TG. Genetic variants associated with response to lithium treatment in bipolar disorder: a genome-wide association study. Lancet, 2016; 387: 1085-1093.
97. Higashiyama R, Ohnuma T, Takebayashi Y, Hanzawa R, Shibata N, Yamamori H, Yasuda Y, Kushima I, Aleksic B, Kondo K, Ikeda M, Hashimoto R, Iwata N, Ozaki N, Arai H. Association of copy number polymorphisms at the promoter and translated region of COMT with Japanese patients with schizophrenia. Am J Med Genet B Neuropsychiatr Genet, 2016; 171: 447-457.
98. Goto A, Mouri A, Nagai T, Yoshimi A, Ukigai M, Tsubai T, Hida H, Ozaki N, Noda Y. Involvement of the histamine H4 receptor in clozapine-induced hematopoietic toxicity: Vulnerability under granulocytic differentiation of HL-60 cells. Toxicol Appl Pharmacol, 2016; 306: 8-16.
99. Fujishiro H, Iritani S, Sekiguchi H, Habuchi C, Torii Y, Matsunaga S, Ozaki N, Yoshida M, Fujita K. Hypochondriasis as an early manifestation of dementia with Lewy bodies: an autopsied case report. Psychogeriatrics, 2016; 16: 139-144.
100. Yamamoto M, Kushima I, Kimura H, Hayashi A, Kawano N, Aleksic B, Iidaka T, Ozaki N. White matter microstructure between the pre-SMA and the cingulum bundle is related to response conflict in healthy subjects. Brain Behav, 2015; 5: e00375.
101. Wang C, Aleksic B, Ozaki N. Glia-related genes and their contribution to schizophrenia. Psychiatry Clin Neurosci, 2015; 69: 448-461.
102. Usami M, Iwadare Y, Watanabe K, Ushijima H, Kodaira M, Okada T, Sasayama D, Sugiyama N, Saito K. A case-control study of the difficulties in daily functioning experienced by children with depressive disorder. J Affect Disord, 2015; 179: 167-174.
103. Uno Y, Uchiyama T, Kurosawa M, Aleksic B, Ozaki N. Early exposure to the combined measles-mumps-rubella vaccine and thimerosal-containing vaccines and risk of autism spectrum disorder. Vaccine, 2015; 33: 2511-2516.
104. Uno K, Nishizawa D, Seo S, Takayama K, Matsumura S, Sakai N, Ohi K, Nabeshima T, Hashimoto R, Ozaki N, Hasegawa J, Sato N, Tanioka F, Sugimura H, Fukuda KI, Higuchi S, Ujike H, Inada T, Iwata N, Sora I, Iyo M, Kondo N, Won MJ, Naruse N, Uehara-Aoyama K, Itokawa M, Yamada M, Ikeda K, Miyamoto Y, Nitta A. The Piccolo Intronic Single Nucleotide Polymorphism rs13438494 Regulates Dopamine and Serotonin Uptake and Shows Associations with Dependence-Like Behavior in Genomic Association Study. Curr Mol Med, 2015; 15: 265-274.
105. Tokura T, Kimura H, Ito M, Nagashima W, Sato N, Kimura Y, Arao M, Aleksic B, Yoshida K, Kurita K, Ozaki N. Temperament and character profiles of patients with burning mouth syndrome. J Psychosom Res, 2015; 78: 495-498.
106. Tanaka S, Yoshida K, Katayama H, Kohmura K, Kawano N, Imaeda M, Kato S, Ando M, Aleksic B, Nishioka K, Ozaki N. Association of Beck Depression Inventory score and Temperament and Character Inventory-125 in patients with eating disorders and severe malnutrition. J Eat Disord, 2015; 3: 36.
107. Takahashi T, Nakamura M, Nakamura Y, Aleksic B, Kido M, Sasabayashi D, Takayanagi Y, Furuichi A, Nishikawa Y, Noguchi K, Ozaki N, Suzuki M. The Disrupted-in-Schizophrenia-1 Ser704Cys polymorphism and brain neurodevelopmental markers in schizophrenia and healthy subjects. Prog Neuropsychopharmacol Biol Psychiatry, 2015; 56: 11-17.
108. Ozaki N, Otsubo T, Kato M, Higuchi T, Ono H, Kamijima K, Group AS. Efficacy of aripiprazole augmentation in Japanese patients with major depressive disorder: A subgroup analysis and Montgomery-Asberg Depression Rating Scale and Hamilton Rating Scale for Depression item analyses of the Aripiprazole Depression Multicenter Efficacy study. Psychiatry Clin Neurosci, 2015; 69: 34-42.
109. Okada T, Ozaki N. What is the nature of the autism 'spectrum'? Psychiatry Clin Neurosci, 2015; 69: 129-130.
110. Okada T, Kubota Y, Sato W, Murai T, Pellion F, Gorog F. Common impairments of emotional facial expression recognition in schizophrenia across French and Japanese cultures. Front Psychol, 2015; 6: 1018.
111. Noda A, Miyaji M, Wakuda Y, Hara Y, Yasuma F, Fukuda T, Iwamoto K, Ozaki N. Simultaneous Measurement of Heart Rate Variability and Blinking Duration to Predict Sleep Onset and Drowsiness in Drivers. J Sleep Disord Ther, 2015; 4: 213.
112. Nishizawa D, Kasai S, Hasegawa J, Sato N, Yamada H, Tanioka F, Nagashima M, Katoh R, Satoh Y, Tagami M, Ujike H, Ozaki N, Inada T, Iwata N, Sora I, Iyo M, Yamada M, Kondo N, Won MJ, Naruse N, Uehara-Aoyama K, Itokawa M, Ohi K, Hashimoto R, Tanisawa K, Arai T, Mori S, Sawabe M, Naka-Mieno M, Yamada Y, Yamada M, Sato N, Muramatsu M, Tanaka M, Irukayama-Tomobe Y, Saito YC, Sakurai T, Hayashida M, Sugimura H, Ikeda K. Associations between the orexin (hypocretin) receptor 2 gene polymorphism Val308Ile and nicotine dependence in genome-wide and subsequent association studies. Mol Brain, 2015; 8: 50.
113. Morikawa M, Okada T, Ando M, Aleksic B, Kunimoto S, Nakamura Y, Kubota C, Uno Y, Tamaji A, Hayakawa N, Furumura K, Shiino T, Morita T, Ishikawa N, Ohoka H, Usui H, Banno N, Murase S, Goto S, Kanai A, Masuda T, Ozaki N. Relationship between social support during pregnancy and postpartum depressive state: a prospective cohort study. Sci Rep, 2015; 5: 10520.
114. Miyata S, Noda A, Iwamoto K, Kawano N, Banno M, Tsuruta Y, Noda Y, Ozaki N. Impaired cortical oxygenation is related to mood disturbance resulting from three nights of sleep restriction. Sleep and Biological Rhythms, 2015; 13: 387-394.
115. Miyata A, Iwamoto K, Kawano N, Kohmura K, Yamamoto M, Aleksic B, Ebe K, Noda A, Noda Y, Iritani S, Ozaki N. The effects of acute treatment with ramelteon, triazolam, and placebo on driving performance, cognitive function, and equilibrium function in healthy volunteers. Psychopharmacology (Berl), 2015; 232: 2127-2137.
116. Kimura H, Tsuboi D, Wang C, Kushima I, Koide T, Ikeda M, Iwayama Y, Toyota T, Yamamoto N, Kunimoto S, Nakamura Y, Yoshimi A, Banno M, Xing J, Takasaki Y, Yoshida M, Aleksic B, Uno Y, Okada T, Iidaka T, Inada T, Suzuki M, Ujike H, Kunugi H, Kato T, Yoshikawa T, Iwata N, Kaibuchi K, Ozaki N. Identification of Rare, Single-Nucleotide Mutations in NDE1 and Their Contributions to Schizophrenia Susceptibility. Schizophr Bull, 2015; 41: 744-753.
117. Kimura H, Tanaka S, Kushima I, Koide T, Banno M, Kikuchi T, Nakamura Y, Shiino T, Yoshimi A, Oya-Ito T, Xing J, Wang C, Takasaki Y, Aleksic B, Okada T, Ikeda M, Inada T, Iidaka T, Iwata N, Ozaki N. Association study of BCL9 gene polymorphism rs583583 with schizophrenia and negative symptoms in Japanese population. Sci Rep, 2015; 5: 15705.
118. Kimura H, Onishi Y, Sunada S, Kishi S, Suzuki N, Tsuboi C, Yamaguchi N, Imai H, Kamei H, Fujisiro H, Okada T, Ishigami M, Ogura Y, Kiuchi T, Ozaki N. Postoperative Psychiatric Complications in Living Liver Donors. Transplant Proc, 2015; 47: 1860-1865.
119. Ito M, Tokura T, Yoshida K, Nagashima W, Kimura H, Umemura E, Tachibana M, Miyauchi T, Kobayashi Y, Arao M, Ozaki N, Kurita K. Five Patients With Burning Mouth Syndrome in Whom an Antidepressant (Serotonin-Noradrenaline Reuptake Inhibitor) Was Not Effective, but Pregabalin Markedly Relieved Pain. Clin Neuropharmacol, 2015; 38: 158-161.
120. Inoue E, Watanabe Y, Xing J, Kushima I, Egawa J, Okuda S, Hoya S, Okada T, Uno Y, Ishizuka K, Sugimoto A, Igeta H, Nunokawa A, Sugiyama T, Ozaki N, Someya T. Resequencing and Association Analysis of CLN8 with Autism Spectrum Disorder in a Japanese Population. PLoS One, 2015; 10: e0144624.
121. Ikeda M, Yoshimura R, Hashimoto R, Kondo K, Saito T, Shimasaki A, Ohi K, Tochigi M, Kawamura Y, Nishida N, Miyagawa T, Sasaki T, Tokunaga K, Kasai K, Takeda M, Nakamura J, Ozaki N, Iwata N. Genetic Overlap Between Antipsychotic Response and Susceptibility to Schizophrenia. J Clin Psychopharmacol, 2015; 35: 85-88.
122. Hida H, Mouri A, Mori K, Matsumoto Y, Seki T, Taniguchi M, Yamada K, Iwamoto K, Ozaki N, Nabeshima T, Noda Y. Blonanserin Ameliorates Phencyclidine-Induced Visual-Recognition Memory Deficits: the Complex Mechanism of Blonanserin Action Involving D3-5-HT2A and D1-NMDA Receptors in the mPFC. Neuropsychopharmacology, 2015; 40: 601-613.
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197. Hayakawa N, Koide T, Okada T, Murase S, Aleksic B, Furumura K, Shiino T, Nakamura Y, Tamaji A, Ishikawa N, Ohoka H, Usui H, Banno N, Morita T, Goto S, Kanai A, Masuda T, Ozaki N. The postpartum depressive state in relation to perceived rearing: a prospective cohort study. PLoS One, 2012; 7: e50220.
198. Hagikura M, Iwamoto K, Aleksic B, Ozaki N. What is a rational antidepressant treatment for major depression in patients with Parkinson's disease? Psychiatry Clin Neurosci, 2012; 66: 463.
199. Furumura K, Koide T, Okada T, Murase S, Aleksic B, Hayakawa N, Shiino T, Nakamura Y, Tamaji A, Ishikawa N, Ohoka H, Usui H, Banno N, Morita T, Goto S, Kanai A, Masuda T, Ozaki N. Prospective Study on the Association between Harm Avoidance and Postpartum Depressive State in a Maternal Cohort of Japanese Women. PLoS One, 2012; 7: e34725.
200. Banno M, Koide T, Aleksic B, Okada T, Kikuchi T, Kohmura K, Adachi Y, Kawano N, Iidaka T, Ozaki N. Wisconsin Card Sorting Test scores and clinical and sociodemographic correlates in Schizophrenia: multiple logistic regression analysis. BMJ Open, 2012; 2.
201. Adachi Y, Aleksic B, Nobata R, Suzuki T, Yoshida K, Ono Y, Ozaki N. Combination use of Beck Depression Inventory and two-question case-finding instrument as a screening tool for depression in the workplace. BMJ Open, 2012; 2.
202. Yoshimura T, Usui H, Takahashi N, Yoshimi A, Saito S, Aleksic B, Ujike H, Inada T, Yamada M, Uchimura N, Iwata N, Sora I, Iyo M, Ozaki N. Association analysis of the GDNF gene with methamphetamine use disorder in a Japanese population. Prog Neuropsychopharmacol Biol Psychiatry, 2011; 35: 1268-1272.
203. Yokobayashi E, Ujike H, Kotaka T, Okahisa Y, Takaki M, Kodama M, Inada T, Uchimura N, Yamada M, Iwata N, Iyo M, Sora I, Ozaki N, Kuroda S. Association study of serine racemase gene with methamphetamine psychosis. Curr Neuropharmacol, 2011; 9: 169-175.
204. Ujike H, Kishimoto M, Okahisa Y, Kodama M, Takaki M, Inada T, Uchimura N, Yamada M, Iwata N, Iyo M, Sora I, Ozaki N. Association Between 5HT1b Receptor Gene and Methamphetamine Dependence. Curr Neuropharmacol, 2011; 9: 163-168.
205. Tsunoka T, Kishi T, Ikeda M, Kitajima T, Yamanouchi Y, Kinoshita Y, Kawashima K, Okochi T, Okumura T, Inada T, Ujike H, Yamada M, Uchimura N, Sora I, Iyo M, Ozaki N, Iwata N. No Association Between GRM3 and Japanese Methamphetamine-Induced Psychosis. Curr Neuropharmacol, 2011; 9: 160-162.
206. Tsunoda A, Iritani S, Ozaki N. Presenile dementia diagnosed as posterior cortical atrophy. Psychogeriatrics, 2011; 11: 171-176.
207. Takata A, Kim SH, Ozaki N, Iwata N, Kunugi H, Inada T, Ujike H, Nakamura K, Mori N, Ahn YM, Joo EJ, Song JY, Kanba S, Yoshikawa T, Kim YS, Kato T. Association of ANK3 with bipolar disorder confirmed in East Asia. Am J Med Genet B Neuropsychiatr Genet, 2011; 156: 312-315.
208. Takahashi N, Nielsen KS, Aleksic B, Petersen S, Ikeda M, Kushima I, Vacaresse N, Ujike H, Iwata N, Dubreuil V, Mirza N, Sakurai T, Ozaki N, Buxbaum JD, Sap J. Loss of Function Studies in Mice and Genetic Association Link Receptor Protein Tyrosine Phosphatase alpha to Schizophrenia. Biol Psychiatry, 2011; 70: 626-635.
209. Sekiguchi H, Iritani S, Habuchi C, Torii Y, Kuroda K, Kaibuchi K, Ozaki N. Impairment of the tyrosine hydroxylase neuronal network in the orbitofrontal cortex of a genetically modified mouse model of schizophrenia. Brain Res, 2011; 1392: 47-53.
210. Okumura T, Okochi T, Kishi T, Ikeda M, Kitajima T, Kinoshita Y, Kawashima K, Tsunoka T, Fukuo Y, Inada T, Yamada M, Uchimura N, Iyo M, Sora I, Ozaki N, Ujike H, Iwata N. Genetic Association Analysis of NOS1 and Methamphetamine-Induced Psychosis Among Japanese. Curr Neuropharmacol, 2011; 9: 155-159.
211. Okochi T, Kishi T, Ikeda M, Kitajima T, Kinoshita Y, Kawashima K, Okumura T, Tsunoka T, Fukuo Y, Inada T, Yamada M, Uchimura N, Iyo M, Sora I, Ozaki N, Ujike H, Iwata N. Genetic Association Analysis of NOS3 and Methamphetamine-Induced Psychosis Among Japanese. Curr Neuropharmacol, 2011; 9: 151-154.
212. Okahisa Y, Kodama M, Takaki M, Inada T, Uchimura N, Yamada M, Iwata N, Iyo M, Sora I, Ozaki N, Ujike H. Association between the Regulator of G-protein Signaling 9 Gene and Patients with Methamphetamine Use Disorder and Schizophrenia. Curr Neuropharmacol, 2011; 9: 190-194.
213. Okahisa Y, Kodama M, Takaki M, Inada T, Uchimura N, Yamada M, Iwata N, Iyo M, Sora I, Ozaki N, Ujike H. Association Study of Two Cannabinoid Receptor Genes, CNR1 and CNR2, with Methamphetamine Dependence. Curr Neuropharmacol, 2011; 9: 183-189.
214. Ogasawara K, Nakamura Y, Aleksic B, Yoshida K, Ando K, Iwata N, Kayukawa Y, Ozaki N. Depression associated with alcohol intake and younger age in Japanese office workers: a case-control and a cohort study. J Affect Disord, 2011; 128: 33-40.
215. Niwa M, Matsumoto Y, Mouri A, Ozaki N, Nabeshima T. Vulnerability in early life to changes in the rearing environment plays a crucial role in the aetiopathology of psychiatric disorders. Int J Neuropsychopharmacol, 2011; 14: 459-477.
216. Miura H, Ando Y, Noda Y, Isobe K, Ozaki N. Long-lasting effects of inescapable-predator stress on brain tryptophan metabolism and the behavior of juvenile mice. Stress, 2011; 14: 262-272.
217. Kubota Y, Takasu NN, Horita S, Kondo M, Shimizu M, Okada T, Wakamura T, Toichi M. Dorsolateral prefrontal cortical oxygenation during REM sleep in humans. Brain Res, 2011; 1389: 83-92.
218. Kobayashi H, Ujike H, Iwata N, Inada T, Yamada M, Sekine Y, Uchimura N, Iyo M, Ozaki N, Itokawa M, Sora I. Association analysis of the tryptophan hydroxylase 2 gene polymorphisms in patients with methamphetamine dependence/psychosis. Curr Neuropharmacol, 2011; 9: 176-182.
219. Kobayashi H, Ujike H, Iwata N, Inada T, Yamada M, Sekine Y, Uchimura N, Iyo M, Ozaki N, Itokawa M, Sora I. Association analysis of the adenosine A1 receptor gene polymorphisms in patients with methamphetamine dependence/psychosis. Curr Neuropharmacol, 2011; 9: 137-142.
220. Kishi T, Yoshimura R, Fukuo Y, Kitajima T, Okochi T, Matsunaga S, Inada T, Kunugi H, Kato T, Yoshikawa T, Ujike H, Umene-Nakano W, Nakamura J, Ozaki N, Serretti A, Correll CU, Iwata N. The CLOCK Gene and Mood Disorders: A Case-Control Study and Meta-analysis. Chronobiol Int, 2011; 28: 825-833.
221. Kishi T, Okochi T, Tsunoka T, Okumura T, Kitajima T, Kawashima K, Yamanouchi Y, Kinoshita Y, Naitoh H, Inada T, Kunugi H, Kato T, Yoshikawa T, Ujike H, Ozaki N, Iwata N. Serotonin 1A receptor gene, schizophrenia and bipolar disorder: An association study and meta-analysis. Psychiatry Res, 2011; 185: 20-26.
222. Kishi T, Okochi T, Kitajima T, Ujike H, Inada T, Yamada M, Uchimura N, Sora I, Iyo M, Ozaki N, Correll CU, Iwata N. Lack of association between translin-associated factor X gene (TSNAX) and methamphetamine dependence in the Japanese population. Prog Neuropsychopharmacol Biol Psychiatry, 2011; 35: 1618-1622.
223. Kishi T, Kitajima T, Tsunoka T, Okumura T, Kawashima K, Okochi T, Yamanouchi Y, Kinoshita Y, Ujike H, Inada T, Yamada M, Uchimura N, Sora I, Iyo M, Ozaki N, Iwata N. Lack of association between prokineticin 2 gene and Japanese methamphetamine dependence. Curr Neuropharmacol, 2011; 9: 133-136.
224. Kishi T, Kitajima T, Kawashima K, Okochi T, Yamanouchi Y, Kinoshita Y, Ujike H, Inada T, Yamada M, Uchimura N, Sora I, Iyo M, Ozaki N, Iwata N. Association Analysis of Nuclear Receptor Rev-erb Alpha Gene (NR1D1) and Japanese Methamphetamine Dependence. Curr Neuropharmacol, 2011; 9: 129-132.
225. Kishi T, Fukuo Y, Okochi T, Kitajima T, Ujike H, Inada T, Yamada M, Uchimura N, Sora I, Iyo M, Ozaki N, Correll CU, Iwata N. No significant association between SIRT1 gene and methamphetamine-induced psychosis in the Japanese population. Hum Psychopharmacol, 2011; 26: 445-450.
226. Kishi T, Fukuo Y, Okochi T, Kitajima T, Kawashima K, Naitoh H, Ujike H, Inada T, Yamada M, Uchimura N, Sora I, Iyo M, Ozaki N, Iwata N. Serotonin 6 receptor gene is associated with methamphetamine-induced psychosis in a Japanese population. Drug Alcohol Depend, 2011; 113: 1-7.
227. Kishi T, Fukuo Y, Kitajima T, Okochi T, Yamanouchi Y, Kinoshita Y, Kawashima K, Inada T, Kunugi H, Kato T, Yoshikawa T, Ujike H, Ozaki N, Iwata N. SIRT1 gene, schizophrenia and bipolar disorder in the Japanese population: an association study. Genes Brain Behav, 2011; 10: 257-263.
228. Kikuchi T, Iwamoto K, Sasada K, Aleksic B, Yoshida K, Ozaki N. Reliability and validity of a new sexual function questionnaire (Nagoya Sexual Function Questionnaire) for schizophrenic patients taking antipsychotics. Hum Psychopharmacol, 2011; 26: 300-306.
229. Ishikawa N, Goto S, Murase S, Kanai A, Masuda T, Aleksic B, Usui H, Ozaki N. Prospective study of maternal depressive symptomatology among Japanese women. J Psychosom Res, 2011; 71: 264-269.
230. Ikeda M, Aleksic B, Kinoshita Y, Okochi T, Kawashima K, Kushima I, Ito Y, Nakamura Y, Kishi T, Okumura T, Fukuo Y, Williams HJ, Hamshere ML, Ivanov D, Inada T, Suzuki M, Hashimoto R, Ujike H, Takeda M, Craddock N, Kaibuchi K, Owen MJ, Ozaki N, O'Donovan MC, Iwata N. Genome-wide association study of schizophrenia in a Japanese population. Biol Psychiatry, 2011; 69: 472-478.
231. Iijima Y, Aleksic B, Ozaki N. Necessity for ethical consideration of research in the aftermath of disaster. Psychiatry Clin Neurosci, 2011; 65: 535-536.
232. Hironaka M, Kotani T, Sumigama S, Tsuda H, Mano Y, Hayakawa H, Tanaka S, Ozaki N, Tamakoshi K, Kikkawa F. Maternal mental disorders and pregnancy outcomes: A clinical study in a Japanese population. J Obstet Gynaecol Res, 2011; 37: 1283-1289.
233. Hashimoto R, Ohi K, Yasuda Y, Fukumoto M, Yamamori H, Takahashi H, Iwase M, Okochi T, Kazui H, Saitoh O, Tatsumi M, Iwata N, Ozaki N, Kamijima K, Kunugi H, Takeda M. Variants of the RELA gene are associated with schizophrenia and their startle responses. Neuropsychopharmacology, 2011; 36: 1921-1931.
234. Hashimoto R, Ohi K, Yasuda Y, Fukumoto M, Yamamori H, Kamino K, Morihara T, Iwase M, Kazui H, Numata S, Ikeda M, Ueno S, Ohmori T, Iwata N, Ozaki N, Takeda M. No association between the PCM1 gene and schizophrenia: A multi-center case-control study and a meta-analysis. Schizophr Res, 2011; 129: 80-84.
235. Habuchi C, Iritani S, Sekiguchi H, Torii Y, Ishihara R, Arai T, Hasegawa M, Tsuchiya K, Akiyama H, Shibayama H, Ozaki N. Clinicopathological study of diffuse neurofibrillary tangles with calcification With special reference to TDP-43 proteinopathy and alpha-synucleinopathy. J Neurol Sci, 2011; 301: 77-85.
236. Fukuo Y, Kishi T, Kushima I, Yoshimura R, Okochi T, Kitajima T, Matsunaga S, Kawashima K, Umene-Nakano W, Naitoh H, Inada T, Nakamura J, Ozaki N, Iwata N. Possible association between ubiquitin-specific peptidase 46 gene and major depressive disorders in the Japanese population. J Affect Disord, 2011; 133: 150-157.
237. Fuchikami M, Morinobu S, Segawa M, Okamoto Y, Yamawaki S, Ozaki N, Inoue T, Kusumi I, Koyama T, Tsuchiyama K, Terao T. DNA methylation profiles of the brain-derived neurotrophic factor (BDNF) gene as a potent diagnostic biomarker in major depression. PLoS One, 2011; 6: e23881.
238. Deng X, Takaki H, Wang L, Kuroki T, Nakahara T, Hashimoto K, Ninomiya H, Arinami T, Inada T, Ujike H, Itokawa M, Tochigi M, Watanabe Y, Someya T, Kunugi H, Iwata N, Ozaki N, Shibata H, Fukumaki Y. Positive association of Phencyclidine-responsive genes, PDE4A and PLAT, with schizophrenia. Am J Med Genet B Neuropsychiatr Genet, 2011; 156: 850-858.
239. Banno M, Koide T, Aleksic B, Yamada K, Kikuchi T, Kohmura K, Adachi Y, Kawano N, Kushima I, Ikeda M, Inada T, Yoshikawa T, Iwata N, Ozaki N. A case control association study and cognitive function analysis of neuropilin and tolloid-like 1 gene and schizophrenia in the Japanese population. PLoS One, 2011; 6: e28929.
240. Yoshimi A, Aleksic B, Kawamura Y, Takahashi N, Yamada S, Usui H, Saito S, Ito Y, Iwata N, Inada T, Noda Y, Yamada K, Ozaki N. Gene-wide association study between the methylenetetrahydrofolate reductase gene (MTHFR) and schizophrenia in the Japanese population, with an updated meta-analysis on currently available data. Schizophr Res, 2010; 124: 216-222.
241. Yazaki S, Koga M, Ishiguro H, Inada T, Ujike H, Itokawa M, Otowa T, Watanabe Y, Someya T, Iwata N, Kunugi H, Ozaki N, Arinami T. An association study between the dymeclin gene and schizophrenia in the Japanese population. J Hum Genet, 2010; 55: 631-634.
242. Ukai K, Matsuo K, Nakamura R, Sobue G, Kosaka K, Shibayama H, Iritani S, Ishihara R, Ozaki N. A case of dementia with Lewy bodies that temporarily showed symptoms similar to Creutzfeldt-Jakob disease. Psychogeriatrics, 2010; 10: 201-205.
243. Tsunoka T, Kishi T, Kitajima T, Okochi T, Okumura T, Yamanouchi Y, Kinoshita Y, Kawashima K, Naitoh H, Inada T, Ujike H, Yamada M, Uchimura N, Sora I, Iyo M, Ozaki N, Iwata N. Association analysis of GRM2 and HTR2A with methamphetamine-induced psychosis and schizophrenia in the Japanese population. Prog Neuropsychopharmacol Biol Psychiatry, 2010; 34: 639-644.
244. Tomida K, Takahashi N, Saito S, Maeno N, Iwamoto K, Yoshida K, Kimura H, Iidaka T, Ozaki N. Relationship of psychopathological symptoms and cognitive function to subjective quality of life in patients with chronic schizophrenia. Psychiatry Clin Neurosci, 2010; 64: 62-69.
245. Takahashi M, Iwamoto K, Kawamura Y, Nakamura Y, Ishihara R, Uchiyama Y, Ebe K, Noda A, Noda Y, Yoshida K, Iidaka T, Ozaki N. The effects of acute treatment with tandospirone, diazepam, and placebo on driving performance and cognitive function in healthy volunteers. Hum Psychopharmacol, 2010; 25: 260-267.
246. Takahashi M, Iwamoto K, Fukatsu H, Naganawa S, Iidaka T, Ozaki N. White matter microstructure of the cingulum and cerebellar peduncle is related to sustained attention and working memory: a diffusion tensor imaging study. Neurosci Lett, 2010; 477: 72-76.
247. Takahashi M, Hayashi H, Watanabe Y, Sawamura K, Fukui N, Watanabe J, Kitajima T, Yamanouchi Y, Iwata N, Mizukami K, Hori T, Shimoda K, Ujike H, Ozaki N, Iijima K, Takemura K, Aoshima H, Someya T. Diagnostic classification of schizophrenia by neural network analysis of blood-based gene expression signatures. Schizophr Res, 2010; 119: 210-218.
248. Syu A, Ishiguro H, Inada T, Horiuchi Y, Tanaka S, Ishikawa M, Arai M, Itokawa M, Niizato K, Iritani S, Ozaki N, Takahashi M, Kakita A, Takahashi H, Nawa H, Keino-Masu K, Arikawa-Hirasawa E, Arinami T. Association of the HSPG2 gene with neuroleptic-induced tardive Dyskinesia. Neuropsychopharmacology, 2010; 35: 1155-1164.
249. Schulze TG, Alda M, Adli M, Akula N, Ardau R, Bui ET, Chillotti C, Cichon S, Czerski P, Del Zompo M, Detera-Wadleigh SD, Grof P, Gruber O, Hashimoto R, Hauser J, Hoban R, Iwata N, Kassem L, Kato T, Kittel-Schneider S, Kliwicki S, Kelsoe JR, Kusumi I, Laje G, Leckband SG, Manchia M, Macqueen G, Masui T, Ozaki N, Perlis RH, Pfennig A, Piccardi P, Richardson S, Rouleau G, Reif A, Rybakowski JK, Sasse J, Schumacher J, Severino G, Smoller JW, Squassina A, Turecki G, Young LT, Yoshikawa T, Bauer M, McMahon FJ. The International Consortium on Lithium Genetics (ConLiGen): An Initiative by the NIMH and IGSLI to Study the Genetic Basis of Response to Lithium Treatment. Neuropsychobiology, 2010; 62: 72-78.
250. Okuda A, Suzuki T, Kishi T, Yamanouchi Y, Umeda K, Haitoh H, Hashimoto S, Ozaki N, Iwata N. Duration of untreated illness and antidepressant fluvoxamine response in major depressive disorder. Psychiatry Clin Neurosci, 2010; 64: 268-273.
251. Okuda A, Kishi T, Okochi T, Ikeda M, Kitajima T, Tsunoka T, Okumukura T, Fukuo Y, Kinoshita Y, Kawashima K, Yamanouchi Y, Inada T, Ozaki N, Iwata N. Translin-associated factor X gene (TSNAX) may be associated with female major depressive disorder in the Japanese population. Neuromolecular Med, 2010; 12: 78-85.
252. Ohnuma T, Shibata N, Baba H, Ohi K, Yasuda Y, Nakamura Y, Okochi T, Naitoh H, Hashimoto R, Iwata N, Ozaki N, Takeda M, Arai H. No association between DAO and schizophrenia in a Japanese patient population: a multicenter replication study. Schizophr Res, 2010; 118: 300-302.
253. Ohi K, Hashimoto R, Yasuda Y, Yoshida T, Takahashi H, Iike N, Iwase M, Kamino K, Ishii R, Kazui H, Fukumoto M, Takamura H, Yamamori H, Azechi M, Ikezawa K, Tanimukai H, Tagami S, Morihara T, Okochi M, Yamada K, Numata S, Ikeda M, Tanaka T, Kudo T, Ueno S, Yoshikawa T, Ohmori T, Iwata N, Ozaki N, Takeda M. The chitinase 3-like 1 gene and schizophrenia: evidence from a multi-center case-control study and meta-analysis. Schizophr Res, 2010; 116: 126-132.
254. Nunokawa A, Watanabe Y, Kaneko N, Sugai T, Yazaki S, Arinami T, Ujike H, Inada T, Iwata N, Kunugi H, Sasaki T, Itokawa M, Ozaki N, Hashimoto R, Someya T. The dopamine D3 receptor (DRD3) gene and risk of schizophrenia: case-control studies and an updated meta-analysis. Schizophr Res, 2010; 116: 61-67.
255. Noda Y, Mouri A, Ando Y, Waki Y, Yamada SN, Yoshimi A, Yamada K, Ozaki N, Wang D, Nabeshima T. Galantamine ameliorates the impairment of recognition memory in mice repeatedly treated with methamphetamine: involvement of allosteric potentiation of nicotinic acetylcholine receptors and dopaminergic-ERK1/2 systems. Int J Neuropsychopharmacol, 2010; 13: 1343-1354.
256. Nishiyama T, Ozaki N. Measurement limit of quality-of-life questionnaires in psychiatric settings. Qual Life Res, 2010; 19: 25-30.
257. Nakamura Y, Ito Y, Aleksic B, Kushima I, Yasui-Furukori N, Inada T, Ono Y, Ozaki N. Influence of HTR2A polymorphisms and parental rearing on personality traits in healthy Japanese subjects. J Hum Genet, 2010; 55: 838-841.
258. Morikawa T, Manabe T, Ito Y, Yamada S, Yoshimi A, Nagai T, Ozaki N, Mayeda A. The expression of HMGA1a is increased in lymphoblastoid cell lines from schizophrenia patients. Neurochem Int, 2010; 56: 736-739.
259. Miyata S, Noda A, Ozaki N, Hara Y, Minoshima M, Iwamoto K, Takahashi M, Iidaka T, Koike Y. Insufficient sleep impairs driving performance and cognitive function. Neurosci Lett, 2010; 469: 229-233.
260. Kushima I, Aleksic B, Ito Y, Nakamura Y, Nakamura K, Mori N, Kikuchi M, Inada T, Kunugi H, Nanko S, Kato T, Yoshikawa T, Ujike H, Suzuki M, Iwata N, Ozaki N. Association study of ubiquitin-specific peptidase 46 (USP46) with bipolar disorder and schizophrenia in a Japanese population. J Hum Genet, 2010; 55: 133-136.
261. Kushima I, Aleksic B, Ikeda M, Yamanouchi Y, Kinoshita Y, Ito Y, Nakamura Y, Inada T, Iwata N, Ozaki N. Association study of bromodomain-containing 1 gene with schizophrenia in Japanese population. Am J Med Genet B Neuropsychiatr Genet, 2010; 153B: 786-791.
262. Koide T, Aleksic B, Ito Y, Usui H, Yoshimi A, Inada T, Suzuki M, Hashimoto R, Takeda M, Iwata N, Ozaki N. A two-stage case-control association study of the dihydropyrimidinase-like 2 gene (DPYSL2) with schizophrenia in Japanese subjects. J Hum Genet, 2010; 55: 469-472.
263. Kobayashi H, Ujike H, Iwata N, Inada T, Yamada M, Sekine Y, Uchimura N, Iyo M, Ozaki N, Itokawa M, Sora I. The adenosine A2A receptor is associated with methamphetamine dependence/psychosis in the Japanese population. Behav Brain Funct, 2010; 6: 50.
264. Kishi T, Yoshimura R, Okochi T, Fukuo Y, Kitajima T, Okumura T, Tsunoka T, Kawashima K, Yamanouchi Y, Kinoshita Y, Umene-Nakano W, Naitoh H, Nakamura J, Ozaki N, Iwata N. Association analysis of SIGMAR1 with major depressive disorder and SSRI response. Neuropharmacology, 2010; 58: 1168-1173.
265. Kishi T, Yoshimura R, Kitajima T, Okochi T, Okumura T, Tsunoka T, Yamanouchi Y, Kinoshita Y, Kawashima K, Naitoh H, Nakamura J, Ozaki N, Iwata N. HTR2A is associated with SSRI response in Major Depressive Disorder in a Japanese cohort. Neuromolecular Med, 2010; 12: 237-242.
266. Kishi T, Yoshimura R, Kitajima T, Okochi T, Okumura T, Tsunoka T, Yamanouchi Y, Kinoshita Y, Kawashima K, Fukuo Y, Naitoh H, Umene-Nakano W, Inada T, Nakamura J, Ozaki N, Iwata N. SIRT1 gene is associated with major depressive disorder in the Japanese population. J Affect Disord, 2010; 126: 167-173.
267. Kishi T, Tsunoka T, Ikeda M, Kitajima T, Kawashima K, Okochi T, Okumura T, Yamanouchi Y, Kinoshita Y, Ujike H, Inada T, Yamada M, Uchimura N, Sora I, Iyo M, Ozaki N, Iwata N. Serotonin 1A receptor gene is associated with Japanese methamphetamine-induced psychosis patients. Neuropharmacology, 2010; 58: 452-456.
268. Kishi T, Kitajima T, Tsunoka T, Okumura T, Okochi T, Kawashima K, Inada T, Ujike H, Yamada M, Uchimura N, Sora I, Iyo M, Ozaki N, Iwata N. PROKR2 is associated with methamphetamine dependence in the Japanese population. Prog Neuropsychopharmacol Biol Psychiatry, 2010; 34: 1033-1036.
269. Kishi T, Fukuo Y, Yoshimura R, Okochi T, Kitajima T, Naitoh H, Umene-Nakano W, Nakamura J, Ozaki N, Iwata N. Pharmacogenetic study of serotonin 6 receptor gene with antidepressant response in major depressive disorder in the Japanese population. Hum Psychopharmacol, 2010; 25: 481-486.
270. Iwayama Y, Hattori E, Maekawa M, Yamada K, Toyota T, Ohnishi T, Iwata Y, Tsuchiya KJ, Sugihara G, Kikuchi M, Hashimoto K, Iyo M, Inada T, Kunugi H, Ozaki N, Iwata N, Nanko S, Iwamoto K, Okazaki Y, Kato T, Yoshikawa T. Association analyses between brain-expressed fatty-acid binding protein (FABP) genes and schizophrenia and bipolar disorder. Am J Med Genet B Neuropsychiatr Genet, 2010; 153B: 484-493.
271. Ito M, Kimura H, Yoshida K, Kimura Y, Ozaki N, Kurita K. Effectiveness of milnacipran for the treatment of chronic pain in the orofacial region. Clin Neuropharmacol, 2010; 33: 79-83.
272. Ishiguro H, Koga M, Horiuchi Y, Noguchi E, Morikawa M, Suzuki Y, Arai M, Niizato K, Iritani S, Itokawa M, Inada T, Iwata N, Ozaki N, Ujike H, Kunugi H, Sasaki T, Takahashi M, Watanabe Y, Someya T, Kakita A, Takahashi H, Nawa H, Arinami T. Supportive evidence for reduced expression of GNB1L in schizophrenia. Schizophr Bull, 2010; 36: 756-765.
273. Ishiguro H, Horiuchi Y, Ishikawa M, Koga M, Imai K, Suzuki Y, Morikawa M, Inada T, Watanabe Y, Takahashi M, Someya T, Ujike H, Iwata N, Ozaki N, Onaivi ES, Kunugi H, Sasaki T, Itokawa M, Arai M, Niizato K, Iritani S, Naka I, Ohashi J, Kakita A, Takahashi H, Nawa H, Arinami T. Brain cannabinoid CB2 receptor in schizophrenia. Biol Psychiatry, 2010; 67: 974-982.
274. Iritani S, Sekiguchi H, Habuchi C, Torii Y, Yamada S, Waki Y, Noda Y, Furukawa H, Nabeshima T, Ozaki N. Immunohistochemical study of vesicle monoamine transporter 2 in the hippocampal formation of PCP-treated mice. Neurosci Res, 2010; 68: 125-130.
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276. Ikeda M, Tomita Y, Mouri A, Koga M, Okochi T, Yoshimura R, Yamanouchi Y, Kinoshita Y, Hashimoto R, Williams HJ, Takeda M, Nakamura J, Nabeshima T, Owen MJ, O'Donovan MC, Honda H, Arinami T, Ozaki N, Iwata N. Identification of novel candidate genes for treatment response to risperidone and susceptibility for schizophrenia: integrated analysis among pharmacogenomics, mouse expression, and genetic case-control association approaches. Biol Psychiatry, 2010; 67: 263-269.
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278. Iidaka T, Saito DN, Komeda H, Mano Y, Kanayama N, Osumi T, Ozaki N, Sadato N. Transient neural activation in human amygdala involved in aversive conditioning of face and voice. J Cogn Neurosci, 2010; 22: 2074-2085.
279. Hashimoto R, Noguchi H, Hori H, Nakabayashi T, Suzuki T, Iwata N, Ozaki N, Kosuga A, Tatsumi M, Kamijima K, Harada S, Takeda M, Saitoh O, Kunugi H. A genetic variation in the dysbindin gene (DTNBP1) is associated with memory performance in healthy controls. World J Biol Psychiatry, 2010; 11: 431-438.
280. Hashimoto R, Hashimoto H, Shintani N, Ohi K, Hori H, Saitoh O, Kosuga A, Tatsumi M, Iwata N, Ozaki N, Kamijima K, Baba A, Takeda M, Kunugi H. Possible association between the pituitary adenylate cyclase-activating polypeptide (PACAP) gene and major depressive disorder. Neurosci Lett, 2010; 468: 300-302.
281. Fukuo Y, Kishi T, Yoshimura R, Kitajima T, Okochi T, Yamanouchi Y, Kinoshita Y, Kawashima K, Naitoh H, Umene-Nakano W, Inada T, Kunugi H, Kato T, Yoshikawa T, Ujike H, Nakamura J, Ozaki N, Iwata N. Serotonin 6 receptor gene and mood disorders: case-control study and meta-analysis. Neurosci Res, 2010; 67: 250-255.
282. Fukuo Y, Kishi T, Okochi T, Kitajima T, Tsunoka T, Okumukura T, Kinoshita Y, Kawashima K, Yamanouchi Y, Umene-Nakano W, Naitoh H, Inada T, Yoshimura R, Nakamura J, Ozaki N, Iwata N. Lack of Association Between MAGEL2 and Schizophrenia and Mood Disorders in the Japanese Population. Neuromolecular Med, 2010; 12: 285-291.
283. Amagane H, Watanabe Y, Kaneko N, Nunokawa A, Muratake T, Ishiguro H, Arinami T, Ujike H, Inada T, Iwata N, Kunugi H, Sasaki T, Hashimoto R, Itokawa M, Ozaki N, Someya T. Failure to find an association between myosin heavy chain 9, non-muscle (MYH9) and schizophrenia: a three-stage case-control association study. Schizophr Res, 2010; 118: 106-112.
284. Aleksic B, Kushima I, Ito Y, Nakamura Y, Ujike H, Suzuki M, Inada T, Hashimoto R, Takeda M, Iwata N, Ozaki N. Genetic association study of KREMEN1 and DKK1 and schizophrenia in a Japanese population. Schizophr Res, 2010; 118: 113-117.
285. Adachi Y, Aleksic B, Ozaki N. Comparison of pharmacological profiles of serotonin norepinephrine reuptake inhibitors. Clinical Neuropsychopharmacology and Therapeutics, 2010; 1: 10-15.
286. Watanabe Y, Nunokawa A, Kaneko N, Muratake T, Arinami T, Ujike H, Inada T, Iwata N, Kunugi H, Itokawa M, Otowa T, Ozaki N, Someya T. Two-stage case-control association study of polymorphisms in rheumatoid arthritis susceptibility genes with schizophrenia. J Hum Genet, 2009; 54: 62-65.
287. Watanabe Y, Nunokawa A, Kaneko N, Arinami T, Ujike H, Inada T, Iwata N, Kunugi H, Itokawa M, Otowa T, Ozaki N, Someya T. A two-stage case-control association study of PADI2 with schizophrenia. J Hum Genet, 2009; 54: 430-432.
288. Ukai K, Shibayama H, Ishihara R, Ozaki N. Distribution of neurofibrillary tangles in diffuse neurofibrillary tangles with calcification. Psychiatry Clin Neurosci, 2009; 63: 646-651.
289. Ujike H, Katsu T, Okahisa Y, Takaki M, Kodama M, Inada T, Uchimura N, Yamada M, Iwata N, Sora I, Iyo M, Ozaki N, Kuroda S. Genetic variants of D2 but not D3 or D4 dopamine receptor gene are associated with rapid onset and poor prognosis of methamphetamine psychosis. Prog Neuropsychopharmacol Biol Psychiatry, 2009; 33: 625-629.
290. Ueno H, Nishigaki Y, Kong QP, Fuku N, Kojima S, Iwata N, Ozaki N, Tanaka M. Analysis of mitochondrial DNA variants in Japanese patients with schizophrenia. Mitochondrion, 2009; 9: 385-393.
291. Tsunoka T, Kishi T, Ikeda M, Kitajima T, Yamanouchi Y, Kinoshita Y, Kawashima K, Okochi T, Okumura T, Inada T, Ozaki N, Iwata N. Association analysis of Group II metabotropic glutamate receptor genes (GRM2 and GRM3) with mood disorders and fluvoxamine response in a Japanese population. Prog Neuropsychopharmacol Biol Psychiatry, 2009; 33: 875-879.
292. Takahashi T, Suzuki M, Tsunoda M, Maeno N, Kawasaki Y, Zhou SY, Hagino H, Niu L, Tsuneki H, Kobayashi S, Sasaoka T, Seto H, Kurachi M, Ozaki N. The Disrupted-in-Schizophrenia-1 Ser704Cys polymorphism and brain morphology in schizophrenia. Psychiatry Res, 2009; 172: 128-135.
293. Suzuki M, Takahashi S, Matsushima E, Tsunoda M, Kurachi M, Okada T, Hayashi T, Ishii Y, Morita K, Maeda H, Katayama S, Kawahara R, Otsuka T, Hirayasu Y, Sekine M, Okubo Y, Motoshita M, Ohta K, Uchiyama M, Kojima T. Exploratory eye movement dysfunction as a discriminator for schizophrenia : a large sample study using a newly developed digital computerized system. Eur Arch Psychiatry Clin Neurosci, 2009; 259: 186-194.
294. Shibata H, Tani A, Chikuhara T, Kikuta R, Sakai M, Ninomiya H, Tashiro N, Iwata N, Ozaki N, Fukumaki Y. Association study of polymorphisms in the group III metabotropic glutamate receptor genes, GRM4 and GRM7, with schizophrenia. Psychiatry Res, 2009; 167: 88-96.
295. Okumura T, Okochi T, Kishi T, Ikeda M, Kitajima T, Yamanouchi Y, Kinoshita Y, Kawashima K, Tsunoka T, Ujike H, Inada T, Ozaki N, Iwata N. No association between polymorphisms of neuronal oxide synthase 1 gene (NOS1) and schizophrenia in a Japanese population. Neuromolecular Med, 2009; 11: 123-127.
296. Okumura T, Kishi T, Okochi T, Ikeda M, Kitajima T, Yamanouchi Y, Kinoshita Y, Kawashima K, Tsunoka T, Inada T, Ozaki N, Iwata N. Genetic Association Analysis of Functional Polymorphisms in Neuronal Nitric Oxide Synthase 1 Gene (NOS1) and Mood Disorders and Fluvoxamine Response in Major Depressive Disorder in the Japanese Population. Neuropsychobiology, 2009; 61: 57-63.
297. Okochi T, Kishi T, Ikeda M, Kitajima T, Kinoshita Y, Kawashima K, Okumura T, Tsunoka T, Inada T, Yamada M, Uchimura N, Iyo M, Sora I, Ozaki N, Ujike H, Iwata N. Genetic association analysis of NRG1 with methamphetamine-induced psychosis in a Japanese population. Prog Neuropsychopharmacol Biol Psychiatry, 2009; 33: 903-905.
298. Okochi T, Ikeda M, Kishi T, Kawashima K, Kinoshita Y, Kitajima T, Yamanouchi Y, Tomita M, Inada T, Ozaki N, Iwata N. Meta-analysis of association between genetic variants in COMT and schizophrenia: an update. Schizophr Res, 2009; 110: 140-148.
299. Okahisa Y, Ujike H, Kotaka T, Morita Y, Kodama M, Inada T, Yamada M, Iwata N, Iyo M, Sora I, Ozaki N, Kuroda S. Association between neuropeptide Y gene and its receptor Y1 gene and methamphetamine dependence. Psychiatry Clin Neurosci, 2009; 63: 417-422.
300. Ohi K, Hashimoto R, Yasuda Y, Yoshida T, Takahashi H, Iike N, Fukumoto M, Takamura H, Iwase M, Kamino K, Ishii R, Kazui H, Sekiyama R, Kitamura Y, Azechi M, Ikezawa K, Kurimoto R, Kamagata E, Tanimukai H, Tagami S, Morihara T, Ogasawara M, Okochi M, Tokunaga H, Numata S, Ikeda M, Ohnuma T, Ueno S, Fukunaga T, Tanaka T, Kudo T, Arai H, Ohmori T, Iwata N, Ozaki N, Takeda M. Association study of the G72 gene with schizophrenia in a Japanese population: a multicenter study. Schizophr Res, 2009; 109: 80-85.
301. Ohi K, Hashimoto R, Yasuda Y, Yamamori H, Hori H, Saitoh O, Tatsumi M, Takeda M, Iwata N, Ozaki N, Kamijima K, Kunugi H. No association between the Bcl2-interacting killer (BIK) gene and schizophrenia. Neurosci Lett, 2009; 463: 60-63.
302. Nishiyama T, Ozaki N, Iwata N. Use of questionnaire infeasibility in order to detect cognitive disorders: example of the Center for Epidemiologic Studies Depression Scale in psychiatry settings. Psychiatry Clin Neurosci, 2009; 63: 23-29.
303. Nishiyama T, Ozaki N, Iwata N. Practice-based depression screening for psychiatry outpatients: feasibility comparison of two-types of Center for Epidemiologic Studies Depression Scales. Psychiatry Clin Neurosci, 2009; 63: 632-638.
304. Nakamura K, Sekine Y, Takei N, Iwata Y, Suzuki K, Anitha A, Inada T, Harano M, Komiyama T, Yamada M, Iwata N, Iyo M, Sora I, Ozaki N, Ujike H, Mori N. An association study of monoamine oxidase A (MAOA) gene polymorphism in methamphetamine psychosis. Neurosci Lett, 2009; 455: 120-123.
305. Miura H, Shirokawa T, Isobe K, Ozaki N. Shifting the balance of brain tryptophan metabolism elicited by isolation housing and systemic administration of lipopolysaccharide in mice. Stress, 2009; 12: 206-214.
306. Kubota K, Inoue K, Hashimoto R, Kumamoto N, Kosuga A, Tatsumi M, Kamijima K, Kunugi H, Iwata N, Ozaki N, Takeda M, Tohyama M. Tumor necrosis factor receptor-associated protein 1 regulates cell adhesion and synaptic morphology via modulation of N-cadherin expression. J Neurochem, 2009; 110: 496-508.
307. Kotaka T, Ujike H, Okahisa Y, Takaki M, Nakata K, Kodama M, Inada T, Yamada M, Uchimura N, Iwata N, Sora I, Iyo M, Ozaki N, Kuroda S. G72 gene is associated with susceptibility to methamphetamine psychosis. Prog Neuropsychopharmacol Biol Psychiatry, 2009; 33: 1046-1049.
308. Koga M, Ishiguro H, Yazaki S, Horiuchi Y, Arai M, Niizato K, Iritani S, Itokawa M, Inada T, Iwata N, Ozaki N, Ujike H, Kunugi H, Sasaki T, Takahashi M, Watanabe Y, Someya T, Kakita A, Takahashi H, Nawa H, Muchardt C, Yaniv M, Arinami T. Involvement of SMARCA2/BRM in the SWI/SNF chromatin-remodeling complex in schizophrenia. Hum Mol Genet, 2009; 18: 2483-2494.
309. Kishi T, Tsunoka T, Ikeda M, Kawashima K, Okochi T, Kitajima T, Kinoshita Y, Okumura T, Yamanouchi Y, Inada T, Ozaki N, Iwata N. Serotonin 1A receptor gene and major depressive disorder: an association study and meta-analysis. J Hum Genet, 2009; 54: 629-633.
310. Kishi T, Kitajima T, Tsunoka T, Okumura T, Ikeda M, Okochi T, Kinoshita Y, Kawashima K, Yamanouchi Y, Ozaki N, Iwata N. Possible association of prokineticin 2 receptor gene (PROKR2) with mood disorders in the Japanese population. Neuromolecular Med, 2009; 11: 114-122.
311. Kishi T, Kitajima T, Tsunoka T, Ikeda M, Yamanouchi Y, Kinoshita Y, Kawashima K, Okochi T, Okumura T, Inada T, Ozaki N, Iwata N. Genetic association analysis of serotonin 2A receptor gene (HTR2A) with bipolar disorder and major depressive disorder in the Japanese population. Neurosci Res, 2009; 64: 231-234.
312. Kishi T, Kitajima T, Ikeda M, Yamanouchi Y, Kinoshita Y, Kawashima K, Okochi T, Ozaki N, Iwata N. Orphan Nuclear Receptor Rev-erb Alpha Gene (NR1D1) and Fluvoxamine Response in Major Depressive Disorder in the Japanese Population. Neuropsychobiology, 2009; 59: 234-238.
313. Kishi T, Kitajima T, Ikeda M, Yamanouchi Y, Kinoshita Y, Kawashima K, Okochi T, Okumura T, Tsunoka T, Ozaki N, Iwata N. CLOCK may predict the response to fluvoxamine treatment in Japanese major depressive disorder patients. Neuromolecular Med, 2009; 11: 53-57.
314. Kishi T, Kitajima T, Ikeda M, Yamanouchi Y, Kinoshita Y, Kawashima K, Okochi T, Okumura T, Tsunoka T, Inada T, Ozaki N, Iwata N. Association study of clock gene (CLOCK) and schizophrenia and mood disorders in the Japanese population. Eur Arch Psychiatry Clin Neurosci, 2009; 259: 293-297.
315. Kishi T, Ikeda M, Kitajima T, Yamanouchi Y, Kinoshita Y, Kawashima K, Okochi T, Tsunoka T, Okumura T, Inada T, Ujike H, Yamada M, Uchimura N, Sora I, Iyo M, Ozaki N, Iwata N. A functional polymorphism in estrogen receptor alpha gene is associated with Japanese methamphetamine induced psychosis. Prog Neuropsychopharmacol Biol Psychiatry, 2009; 33: 895-898.
316. Kishi T, Ikeda M, Kitajima T, Yamanouchi Y, Kinoshita Y, Kawashima K, Okochi T, Okumura T, Tsunoka T, Inada T, Ozaki N, Iwata N. Association analysis of functional polymorphism in estrogen receptor alpha gene with schizophrenia and mood disorders in the Japanese population. Psychiatr Genet, 2009; 19: 217-218.
317. Kawashima K, Ikeda M, Kishi T, Kitajima T, Yamanouchi Y, Kinoshita Y, Okochi T, Aleksic B, Tomita M, Okada T, Kunugi H, Inada T, Ozaki N, Iwata N. BDNF is not associated with schizophrenia: data from a Japanese population study and meta-analysis. Schizophr Res, 2009; 112: 72-79.
318. Hattori E, Toyota T, Ishitsuka Y, Iwayama Y, Yamada K, Ujike H, Morita Y, Kodama M, Nakata K, Minabe Y, Nakamura K, Iwata Y, Takei N, Mori N, Naitoh H, Yamanouchi Y, Iwata N, Ozaki N, Kato T, Nishikawa T, Kashiwa A, Suzuki M, Shioe K, Shinohara M, Hirano M, Nanko S, Akahane A, Ueno M, Kaneko N, Watanabe Y, Someya T, Hashimoto K, Iyo M, Itokawa M, Arai M, Nankai M, Inada T, Yoshida S, Kunugi H, Nakamura M, Iijima Y, Okazaki Y, Higuchi T, Yoshikawa T. Preliminary genome-wide association study of bipolar disorder in the Japanese population. Am J Med Genet B Neuropsychiatr Genet, 2009; 150B: 1110-1117.
319. Hakamata Y, Iwase M, Iwata H, Kobayashi T, Tamaki T, Nishio M, Matsuda H, Ozaki N, Inada T. Gender difference in relationship between anxiety-related personality traits and cerebral brain glucose metabolism. Psychiatry Res, 2009; 173: 206-211.
320. Arai S, Shibata H, Sakai M, Ninomiya H, Iwata N, Ozaki N, Fukumaki Y. Association analysis of the glutamic acid decarboxylase 2 and the glutamine synthetase genes (GAD2, GLUL) with schizophrenia. Psychiatr Genet, 2009; 19: 6-13.
321. Yoshimi A, Takahashi N, Saito S, Ito Y, Aleksic B, Usui H, Kawamura Y, Waki Y, Yoshikawa T, Kato T, Iwata N, Inada T, Noda Y, Ozaki N. Genetic analysis of the gene coding for DARPP-32 (PPP1R1B) in Japanese patients with schizophrenia or bipolar disorder. Schizophr Res, 2008; 100: 334-341.
322. Yoshida K, Higuchi H, Takahashi H, Kamata M, Sato K, Inoue K, Suzuki T, Itoh K, Ozaki N. Influence of the tyrosine hydroxylase val81met polymorphism and catechol-O-methyltransferase val158met polymorphism on the antidepressant effect of milnacipran. Hum Psychopharmacol, 2008; 23: 121-128.
323. Yamasaki N, Maekawa M, Kobayashi K, Kajii Y, Maeda J, Soma M, Takao K, Tanda K, Ohira K, Toyama K, Kanzaki K, Fukunaga K, Sudo Y, Ichinose H, Ikeda M, Iwata N, Ozaki N, Suzuki H, Higuchi M, Suhara T, Yuasa S, Miyakawa T. Alpha-CaMKII deficiency causes immature dentate gyrus, a novel candidate endophenotype of psychiatric disorders. Mol Brain, 2008; 1: 6.
324. Uhl GR, Drgon T, Liu QR, Johnson C, Walther D, Komiyama T, Harano M, Sekine Y, Inada T, Ozaki N, Iyo M, Iwata N, Yamada M, Sora I, Chen CK, Liu HC, Ujike H, Lin SK. Genome-wide association for methamphetamine dependence: convergent results from 2 samples. Arch Gen Psychiatry, 2008; 65: 345-355.
325. Tanaka M, Kobayashi D, Murakami Y, Ozaki N, Suzuki T, Iwata N, Haraguchi K, Ieiri I, Kinukawa N, Hosoi M, Ohtani H, Sawada Y, Mine K. Genetic polymorphisms in the 5-hydroxytryptamine type 3B receptor gene and paroxetine-induced nausea. Int J Neuropsychopharmacol, 2008; 11: 261-267.
326. Takahashi T, Suzuki M, Tsunoda M, Kawamura Y, Takahashi N, Tsuneki H, Kawasaki Y, Zhou SY, Kobayashi S, Sasaoka T, Seto H, Kurachi M, Ozaki N. Association between the brain-derived neurotrophic factor Val66Met polymorphism and brain morphology in a Japanese sample of schizophrenia and healthy comparisons. Neurosci Lett, 2008; 435: 34-39.
327. Takahashi T, Suzuki M, Tsunoda M, Kawamura Y, Takahashi N, Maeno N, Kawasaki Y, Zhou SY, Hagino H, Niu L, Tsuneki H, Kobayashi S, Sasaoka T, Seto H, Kurachi M, Ozaki N. The association of genotypic combination of the DRD3 and BDNF polymorphisms on the adhesio interthalamica and medial temporal lobe structures. Prog Neuropsychopharmacol Biol Psychiatry, 2008; 32: 1236-1242.
328. Sukegawa M, Noda A, Soga T, Adachi Y, Tsuruta Y, Ozaki N, Koike Y. Comparison of sleep-disordered breathing and heart rate variability between hemodialysis and non-hemodialysis days in hemodialysis patients. Nagoya J Med Sci, 2008; 70: 83-88.
329. Saito S, Takahashi N, Maeno N, Ito Y, Aleksic B, Usui H, Iidaka T, Inada T, Ozaki N. An association study of tachykinin receptor 3 gene with schizophrenia in the Japanese population. Neuroreport, 2008; 19: 471-473.
330. Otani K, Ujike H, Sakai A, Okahisa Y, Kotaka T, Inada T, Harano M, Komiyama T, Hori T, Yamada M, Sekine Y, Iwata N, Iyo M, Sora I, Ozaki N, Kuroda S. Reduced CYP2D6 activity is a negative risk factor for methamphetamine dependence. Neurosci Lett, 2008; 434: 88-92.
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332. Ohtsuki T, Koga M, Ishiguro H, Horiuchi Y, Arai M, Niizato K, Itokawa M, Inada T, Iwata N, Iritani S, Ozaki N, Kunugi H, Ujike H, Watanabe Y, Someya T, Arinami T. A polymorphism of the metabotropic glutamate receptor mGluR7 (GRM7) gene is associated with schizophrenia. Schizophr Res, 2008; 101: 9-16.
333. Ohtsuki T, Horiuchi Y, Koga M, Ishiguro H, Inada T, Iwata N, Ozaki N, Ujike H, Watanabe Y, Someya T, Arinami T. Association of polymorphisms in the haplotype block spanning the alternatively spliced exons of the NTNG1 gene at 1p13.3 with schizophrenia in Japanese populations. Neurosci Lett, 2008; 435: 194-197.
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335. Niwa M, Nitta A, Cen X, Kitaichi K, Ozaki N, Yamada K, Nabeshima T. A novel molecule 'shati' increases dopamine uptake via the induction of tumor necrosis factor-alpha in pheochromocytoma-12 cells. J Neurochem, 2008; 107: 1697-1708.
336. Morita Y, Ujike H, Tanaka Y, Kishimoto M, Okahisa Y, Kotaka T, Harano M, Inada T, Komiyama T, Hori T, Yamada M, Sekine Y, Iwata N, Iyo M, Sora I, Ozaki N, Kuroda S. The glycine transporter 1 gene (GLYT1) is associated with methamphetamine-use disorder. Am J Med Genet B Neuropsychiatr Genet, 2008; 147: 54-58.
337. Miura H, Ozaki N, Shirokawa T, Isobe K. Changes in brain tryptophan metabolism elicited by ageing, social environment, and psychological stress in mice. Stress, 2008; 11: 160-169.
338. Miura H, Ozaki N, Sawada M, Isobe K, Ohta T, Nagatsu T. A link between stress and depression: shifts in the balance between the kynurenine and serotonin pathways of tryptophan metabolism and the etiology and pathophysiology of depression. Stress, 2008; 11: 198-209.
339. Masui T, Hashimoto R, Kusumi I, Suzuki K, Tanaka T, Nakagawa S, Suzuki T, Iwata N, Ozaki N, Kato T, Takeda M, Kunugi H, Koyama T. A possible association between missense polymorphism of the breakpoint cluster region gene and lithium prophylaxis in bipolar disorder. Prog Neuropsychopharmacol Biol Psychiatry, 2008; 32: 204-208.
340. Kuratomi G, Iwamoto K, Bundo M, Kusumi I, Kato N, Iwata N, Ozaki N, Kato T. Aberrant DNA methylation associated with bipolar disorder identified from discordant monozygotic twins. Mol Psychiatry, 2008; 13: 429-441.
341. Kotaka T, Ujike H, Morita Y, Kishimoto M, Okahisa Y, Inada T, Harano M, Komiyama T, Hori T, Yamada M, Sekine Y, Iwata N, Iyo M, Sora I, Ozaki N, Kuroda S. Association study between casein kinase 1 epsilon gene and methamphetamine dependence. Ann N Y Acad Sci, 2008; 1139: 43-48.
342. Kishimoto M, Ujike H, Okahisa Y, Kotaka T, Takaki M, Kodama M, Inada T, Yamada M, Uchimura N, Iwata N, Sora I, Iyo M, Ozaki N, Kuroda S. The Frizzled 3 gene is associated with methamphetamine psychosis in the Japanese population. Behav Brain Funct, 2008; 4: 37.
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347. Kishi T, Ikeda M, Kitajima T, Yamanouchi Y, Kinoshita Y, Kawashima K, Inada T, Harano M, Komiyama T, Hori T, Yamada M, Iyo M, Sora I, Sekine Y, Ozaki N, Ujike H, Iwata N. Alpha4 and beta2 subunits of neuronal nicotinic acetylcholine receptor genes are not associated with methamphetamine-use disorder in the Japanese population. Ann N Y Acad Sci, 2008; 1139: 70-82.
348. Kishi T, Ikeda M, Kitajima T, Yamanouchi Y, Kinoshita Y, Kawashima K, Inada T, Harano M, Komiyama T, Hori T, Yamada M, Iyo M, Sora I, Sekine Y, Ozaki N, Ujike H, Iwata N. Glutamate cysteine ligase modifier (GCLM) subunit gene is not associated with methamphetamine-use disorder or schizophrenia in the Japanese population. Ann N Y Acad Sci, 2008; 1139: 63-69.
349. Kishi T, Ikeda M, Kitajima T, Suzuki T, Yamanouchi Y, Kinoshita Y, Kawashima K, Ozaki N, Iwata N. No association between prostate apoptosis response 4 gene (PAWR) in schizophrenia and mood disorders in a Japanese population. Am J Med Genet B Neuropsychiatr Genet, 2008; 147B: 531-534.
350. Kinoshita Y, Ikeda M, Ujike H, Kitajima T, Yamanouchi Y, Aleksic B, Kishi T, Kawashima K, Ohkouchi T, Ozaki N, Inada T, Harano M, Komiyama T, Hori T, Yamada M, Sekine Y, Iyo M, Sora I, Iwata N. Association study of the calcineurin A gamma subunit gene (PPP3CC) and methamphetamine-use disorder in a Japanese population. Ann N Y Acad Sci, 2008; 1139: 57-62.
351. Kawashima K, Kishi T, Ikeda M, Kitajima T, Yamanouchi Y, Kinoshita Y, Takahashi N, Saito S, Ohi K, Yasuda Y, Hashimoto R, Takeda M, Inada T, Ozaki N, Iwata N. No association between tagging SNPs of SNARE complex genes (STX1A, VAMP2 and SNAP25) and schizophrenia in a Japanese population. Am J Med Genet B Neuropsychiatr Genet, 2008; 147B: 1327-1331.
352. Kanahara N, Miyatake R, Sekine Y, Inada T, Ozaki N, Iwata N, Harano M, Komiyama T, Yamada M, Sora I, Ujike H, Iyo M, Hashimoto K. Association study between the PIK4CA gene and methamphetamine use disorder in a Japanese population. Am J Med Genet B Neuropsychiatr Genet, 2008; 150B: 233-238.
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354. Ji X, Takahashi N, Saito S, Ishihara R, Maeno N, Inada T, Ozaki N. Relationship between three serotonin receptor subtypes (HTR3A, HTR2A and HTR4) and treatment-resistant schizophrenia in the Japanese population. Neurosci Lett, 2008; 435: 95-98.
355. Ji X, Takahashi N, Branko A, Ishihara R, Nagai T, Mouri A, Saito S, Maeno N, Inada T, Ozaki N. An association between serotonin receptor 3B gene (HTR3B) and treatment-resistant schizophrenia (TRS) in a Japanese population. Nagoya J Med Sci, 2008; 70: 11-17.
356. Iwamoto K, Takahashi M, Nakamura Y, Kawamura Y, Ishihara R, Uchiyama Y, Ebe K, Noda A, Noda Y, Yoshida K, Iidaka T, Ozaki N. The effects of acute treatment with paroxetine, amitriptyline, and placebo on driving performance and cognitive function in healthy Japanese subjects: a double-blind crossover trial. Hum Psychopharmacol, 2008; 23: 399-407.
357. Iwamoto K, Kawamura Y, Takahashi M, Uchiyama Y, Ebe K, Yoshida K, Iidaka T, Noda Y, Ozaki N. Plasma amitriptyline level after acute administration, and driving performance in healthy volunteers. Psychiatry Clin Neurosci, 2008; 62: 610-616.
358. Ito Y, Yamada S, Takahashi N, Saito S, Yoshimi A, Inada T, Noda Y, Ozaki N. No association between the protein tyrosine phosphatase, receptor-type, Z Polypeptide 1 (PTPRZ1) gene and schizophrenia in the Japanese population. Am J Med Genet B Neuropsychiatr Genet, 2008; 147B: 1013-1018.
359. Ito Y, Nakamura Y, Takahashi N, Saito S, Aleksic B, Iwata N, Inada T, Ozaki N. A genetic association study of the FXYD domain containing ion transport regulator 6 (FXYD6) gene, encoding phosphohippolin, in susceptibility to schizophrenia in a Japanese population. Neurosci Lett, 2008; 438: 70-75.
360. Ishiguro H, Imai K, Koga M, Horiuchi Y, Inada T, Iwata N, Ozaki N, Ujike H, Itokawa M, Kunugi H, Sasaki T, Watanabe Y, Someya T, Arinami T. Replication study for associations between polymorphisms in the CLDN5 and DGCR2 genes in the 22q11 deletion syndrome region and schizophrenia. Psychiatr Genet, 2008; 18: 255-256.
361. Inada T, Koga M, Ishiguro H, Horiuchi Y, Syu A, Yoshio T, Takahashi N, Ozaki N, Arinami T. Pathway-based association analysis of genome-wide screening data suggest that genes associated with the gamma-aminobutyric acid receptor signaling pathway are involved in neuroleptic-induced, treatment-resistant tardive dyskinesia. Pharmacogenet Genomics, 2008; 18: 317-323.
362. Ikeda M, Yamanouchi Y, Kinoshita Y, Kitajima T, Yoshimura R, Hashimoto S, O'Donovan MC, Nakamura J, Ozaki N, Iwata N. Variants of dopamine and serotonin candidate genes as predictors of response to risperidone treatment in first-episode schizophrenia. Pharmacogenomics, 2008; 9: 1437-1443.
363. Ikeda M, Takahashi N, Saito S, Aleksic B, Watanabe Y, Nunokawa A, Yamanouchi Y, Kitajima T, Kinoshita Y, Kishi T, Kawashima K, Hashimoto R, Ujike H, Inada T, Someya T, Takeda M, Ozaki N, Iwata N. Failure to replicate the association between NRG1 and schizophrenia using Japanese large sample. Schizophr Res, 2008; 101: 1-8.
364. Ikeda M, Hikita T, Taya S, Uraguchi-Asaki J, Toyo-oka K, Wynshaw-Boris A, Ujike H, Inada T, Takao K, Miyakawa T, Ozaki N, Kaibuchi K, Iwata N. Identification of YWHAE, a gene encoding 14-3-3epsilon, as a possible susceptibility gene for schizophrenia. Hum Mol Genet, 2008; 17: 3212-3222.
365. Hashimoto T, Hashimoto K, Miyatake R, Matsuzawa D, Sekine Y, Inada T, Ozaki N, Iwata N, Harano M, Komiyama T, Yamada M, Sora I, Ujike H, Iyo M. Association study between polymorphisms in glutathione-related genes and methamphetamine use disorder in a Japanese population. Am J Med Genet B Neuropsychiatr Genet, 2008; 147B: 1040-1046.
366. Deng X, Sagata N, Takeuchi N, Tanaka M, Ninomiya H, Iwata N, Ozaki N, Shibata H, Fukumaki Y. Association study of polymorphisms in the neutral amino acid transporter genes SLC1A4, SLC1A5 and the glycine transporter genes SLC6A5, SLC6A9 with schizophrenia. BMC Psychiatry, 2008; 8: 58.
367. Aleksic B, Ikeda M, Ishihara R, Saito S, Inada T, Iwata N, Ozaki N. No association between the oligodendrocyte-related gene PLP1 and schizophrenia in the Japanese population. J Hum Genet, 2008; 53: 863-866.
368. Albalushi T, Horiuchi Y, Ishiguro H, Koga M, Inada T, Iwata N, Ozaki N, Ujike H, Watanabe Y, Someya T, Arinami T. Replication study and meta-analysis of the genetic association of GRM3 gene polymorphisms with schizophrenia in a large Japanese case-control population. Am J Med Genet B Neuropsychiatr Genet, 2008; 147: 392-396.
369. Yoshida K, Higuchi H, Ozaki N. Successful treatment of severe antidepressant-induced nausea with a combination of milnacipran and olanzapine. Pharmacopsychiatry, 2007; 40: 84-85.
370. Yoshida K, Higuchi H, Kamata M, Takahashi H, Inoue K, Suzuki T, Itoh K, Ozaki N. The G196A polymorphism of the brain-derived neurotrophic factor gene and the antidepressant effect of milnacipran and fluvoxamine. J Psychopharmacol, 2007; 21: 650-656.
371. Urata T, Takahashi N, Hakamata Y, Iijima Y, Kuwahara N, Ozaki N, Ono Y, Amano M, Inada T. Gene-gene interaction analysis of personality traits in a Japanese population using an electrochemical DNA array chip analysis. Neurosci Lett, 2007; 414: 209-212.
372. Tomita Y, Ikeda M, Mutoh H, Inada T, Iwata N, Ozaki N, Honda H. Association study between Apolipoprotein L and schizophrenia by exhaustive and rule-based combination analysis for identification of multilocus interactions. J Biosci Bioeng, 2007; 103: 303-310.
373. Tabuse H, Kalali A, Azuma H, Ozaki N, Iwata N, Naitoh H, Higuchi T, Kanba S, Shioe K, Akechi T, Furukawa TA. The new GRID Hamilton Rating Scale for Depression demonstrates excellent inter-rater reliability for inexperienced and experienced raters before and after training. Psychiatry Res, 2007; 153: 61-67.
374. Sato W, Okada T, Toichi M. Attentional shift by gaze is triggered without awareness. Exp Brain Res, 2007; 183: 87-94.
375. Saito S, Takahashi N, Ishihara R, Ikeda M, Suzuki T, Kitajima T, Yamanouchi Y, Iwata N, Yamada M, Yoshida K, Inada T, Ozaki N. Association Study between Vesicle-Associated Membrane Protein 2 Gene Polymorphisms and Fluvoxamine Response in Japanese Major Depressive Patients. Neuropsychobiology, 2007; 54: 226-230.
376. Ohnishi T, Yamada K, Ohba H, Iwayama Y, Toyota T, Hattori E, Inada T, Kunugi H, Tatsumi M, Ozaki N, Iwata N, Sakamoto K, Iijima Y, Iwata Y, Tsuchiya KJ, Sugihara G, Nanko S, Osumi N, Detera-Wadleigh SD, Kato T, Yoshikawa T. A Promoter Haplotype of the Inositol Monophosphatase 2 Gene (IMPA2) at 18p11.2 Confers a Possible Risk for Bipolar Disorder by Enhancing Transcription. Neuropsychopharmacology, 2007; 32: 1727-1737.
377. Nakayama H, Kitaichi K, Ito Y, Hashimoto K, Takagi K, Yokoi T, Ozaki N, Yamamoto T, Hasegawa T. The role of organic cation transporter-3 in methamphetamine disposition and its behavioral response in rats. Brain Res, 2007; 1184: 260-269.
378. Mouri A, Noda Y, Noda A, Nakamura T, Tokura T, Yura Y, Nitta A, Furukawa H, Nabeshima T. Involvement of a dysfunctional dopamine-D1/N-methyl-d-aspartate-NR1 and Ca2+/calmodulin-dependent protein kinase II pathway in the impairment of latent learning in a model of schizophrenia induced by phencyclidine. Mol Pharmacol, 2007; 71: 1598-1609.
379. Miura H, Kitagami T, Ozaki N. Suppressive effect of paroxetine, a selective serotonin uptake inhibitor, on tetrahydrobiopterin levels and dopamine as well as serotonin turnover in the mesoprefrontal system of mice. Synapse, 2007; 61: 698-706.
380. Matsuzawa D, Hashimoto K, Miyatake R, Shirayama Y, Shimizu E, Maeda K, Suzuki Y, Mashimo Y, Sekine Y, Inada T, Ozaki N, Iwata N, Harano M, Komiyama T, Yamada M, Sora I, Ujike H, Hata A, Sawa A, Iyo M. Identification of Functional Polymorphisms in the Promoter Region of the Human PICK1 Gene and Their Association With Methamphetamine Psychosis. Am J Psychiatry, 2007; 164: 1105-1114.
381. Maeno N, Takahashi N, Saito S, Ji X, Ishihara R, Aoyama N, Branko A, Miura H, Ikeda M, Suzuki T, Kitajima T, Yamanouchi Y, Kinoshita Y, Iwata N, Inada T, Ozaki N. Association of SOX10 with schizophrenia in the Japanese population. Psychiatr Genet, 2007; 17: 227-231.
382. Maeno N, Takahashi N, Saito S, Ji X, Branko A, Ishihara R, Yoshida K, Inada T, Iidaka T, Ozaki N. Association study between the transferrin gene and schizophrenia in the Japanese population. Neuroreport, 2007; 18: 517-520.
383. Koga M, Ishiguro H, Horiuchi Y, Albalushi T, Inada T, Iwata N, Ozaki N, Ujike H, Muratake T, Someya T, Arinami T. Failure to confirm the association between the FEZ1 gene and schizophrenia in a Japanese population. Neurosci Lett, 2007; 417: 326-329.
384. Kimura H, Tonoike T, Muroya T, Yoshida K, Ozaki N. Age of onset has limited association with body mass index at time of presentation for anorexia nervosa: Comparison of peak-onset and late-onset anorexia nervosa groups. Psychiatry Clin Neurosci, 2007; 61: 646-650.
385. Ito M, Yoshida K, Kimura H, Ozaki N, Kurita K. Successful Treatment of Trigeminal Neuralgia With Milnacipran. Clin Neuropharmacol, 2007; 30: 183-185.
386. Ishiguro H, Koga M, Horiuchi Y, Inada T, Iwata N, Ozaki N, Ujike H, Muratake T, Someya T, Arinami T. PICK1 is not a susceptibility gene for schizophrenia in a Japanese population: Association study in a large case-control population. Neurosci Res, 2007; 58: 145-148.
387. Ishiguro H, Horiuchi Y, Koga M, Inada T, Iwata N, Ozaki N, Ujike H, Muratake T, Someya T, Arinami T. RGS4 is not a susceptibility gene for schizophrenia in Japanese: association study in a large case-control population. Schizophr Res, 2007; 89: 161-164.
388. Ikeda M, Ozaki N, Yamanouchi Y, Suzuki T, Kitajima T, Kinoshita Y, Inada T, Iwata N. No association between the glutamate decarboxylase 67 gene (GAD1) and schizophrenia in the Japanese population. Schizophr Res, 2007; 91: 22-26.
389. Ikeda M, Ozaki N, Suzuki T, Kitajima T, Yamanouchi Y, Kinoshita Y, Kishi T, Sekine Y, Iyo M, Harano M, Komiyama T, Yamada M, Sora I, Ujike H, Inada T, Iwata N. Possible association of beta-arrestin 2 gene with methamphetamine use disorder, but not schizophrenia. Genes Brain Behav, 2007; 6: 107-112.
390. Horiuchi Y, Ishiguro H, Koga M, Inada T, Iwata N, Ozaki N, Ujike H, Muratake T, Someya T, Arinami T. Support for association of the PPP3CC gene with schizophrenia. Mol Psychiatry, 2007; 12: 891-893.
391. Hashimoto R, Hashimoto H, Shintani N, Chiba S, Hattori S, Okada T, Nakajima M, Tanaka K, Kawagishi N, Nemoto K, Mori T, Ohnishi T, Noguchi H, Hori H, Suzuki T, Iwata N, Ozaki N, Nakabayashi T, Saitoh O, Kosuga A, Tatsumi M, Kamijima K, Weinberger DR, Kunugi H, Baba A. Pituitary adenylate cyclase-activating polypeptide is associated with schizophrenia. Mol Psychiatry, 2007; 12: 1026-1032.
392. Deng X, Shibata H, Takeuchi N, Rachi S, Sakai M, Ninomiya H, Iwata N, Ozaki N, Fukumaki Y. Association study of polymorphisms in the glutamate transporter genes SLC1A1, SLC1A3, and SLC1A6 with schizophrenia. Am J Med Genet B Neuropsychiatr Genet, 2007; 144: 271-278.
393. Aleksic B, Ishihara R, Takahashi N, Maeno N, Ji X, Saito S, Inada T, Ozaki N. Gap junction coding genes and schizophrenia: a genetic association study. J Hum Genet, 2007; 52: 498-501.
394. Usui H, Takahashi N, Saito S, Ishihara R, Aoyama N, Ikeda M, Suzuki T, Kitajima T, Yamanouchi Y, Kinoshita Y, Yoshida K, Iwata N, Inada T, Ozaki N. The 2',3'-cyclic nucleotide 3'-phosphodiesterase and oligodendrocyte lineage transcription factor 2 genes do not appear to be associated with schizophrenia in the Japanese population. Schizophr Res, 2006; 88: 245-250.
395. Ujike H, Sakai A, Nakata K, Tanaka Y, Kodaka T, Okahisa Y, Harano M, Inada T, Yamada M, Komiyama T, Hori T, Sekine Y, Iwata N, Sora I, Iyo M, Ozaki N, Kuroda S. Association Study of the Dihydropyrimidinase-Related Protein 2 Gene and Methamphetamine Psychosis. Ann N Y Acad Sci, 2006; 1074: 90-96.
396. Takahashi N, Ishihara R, Saito S, Maemo N, Aoyama N, Ji X, Miura H, Ikeda M, Iwata N, Suzuki T, Kitajima T, Yamanouchi Y, Kinoshita Y, Ozaki N, Inada T. Association between chromogranin A gene polymorphism and schizophrenia in the Japanese population. Schizophr Res, 2006; 83: 179-183.
397. Suzuki A, Nakamura K, Sekine Y, Minabe Y, Takei N, Suzuki K, Iwata Y, Kawai M, Takebayashi K, Matsuzaki H, Iyo M, Ozaki N, Inada T, Iwata N, Harano M, Komiyama T, Yamada M, Sora I, Ujike H, Mori N. An association study between catechol-O-methyl transferase gene polymorphism and methamphetamine psychotic disorder. Psychiatr Genet, 2006; 16: 133-138.
398. Shibata H, Aramaki T, Sakai M, Ninomiya H, Tashiro N, Iwata N, Ozaki N, Fukumaki Y. Association study of polymorphisms in the GluR7, KA1 and KA2 kainate receptor genes (GRIK3, GRIK4, GRIK5) with schizophrenia. Psychiatry Res, 2006; 141: 39-51.
399. Okada T, Sato W, Toichi M. Right hemispheric dominance in gaze-triggered reflexive shift of attention in humans. Brain Cogn, 2006; 62: 128-133.
400. Nomura A, Ujike H, Tanaka Y, Otani K, Morita Y, Kishimoto M, Morio A, Harano M, Inada T, Yamada M, Komiyama T, Sekine Y, Iwata N, Sora I, Iyo M, Ozaki N, Kuroda S. Genetic variant of prodynorphin gene is risk factor for methamphetamine dependence. Neurosci Lett, 2006; 400: 158-162.
401. Nomura A, Ujike H, Tanaka Y, Kishimoto M, Otani K, Morita Y, Morio A, Harano M, Inada T, Yamada M, Komiyama T, Hori T, Sekine Y, Iwata N, Sora I, Iyo M, Ozaki N, Kuroda S. Association Study of the Tumor Necrosis Factor-{alpha} Gene and Its 1A Receptor Gene with Methamphetamine Dependence. Ann N Y Acad Sci, 2006; 1074: 116-124.
402. Noda A, Nakai S, Soga T, Sugiura T, Iwayama N, Maeda K, Atarashi M, Yasuma F, Ozaki N, Yokota M, Koike Y. Factors contributing to sleep disturbance and hypnotic drug use in hemodialysis patients. Intern Med, 2006; 45: 1273-1278.
403. Nakamura K, Chen CK, Sekine Y, Iwata Y, Anitha A, Loh el W, Takei N, Suzuki A, Kawai M, Takebayashi K, Suzuki K, Minabe Y, Tsuchiya K, Yamada K, Iyo M, Ozaki N, Inada T, Iwata N, Harano M, Komiyama T, Yamada M, Sora I, Ujike H, Ball DM, Yoshikawa T, Lin SK, Mori N. Association analysis of SOD2 variants with methamphetamine psychosis in Japanese and Taiwanese populations. Hum Genet, 2006; 120: 243-252.
404. Nakajima A, Kamitsuji S, Saito A, Tanaka E, Nishimura K, Horikawa N, Ozaki N, Tomatsu T, Hara M, Kamatani N, Yamanaka H. Disability and patient's appraisal of general health contribute to depressed mood in rheumatoid arthritis in a large clinical study in Japan. Mod Rheumatol, 2006; 16: 151-157.
405. Morio A, Ujike H, Nomura A, Tanaka Y, Morita Y, Otani K, Kishimoto M, Harano M, Inada T, Komiyama T, Yamada M, Sekine Y, Iwata N, Iyo M, Sora I, Ozaki N, Kuroda S. No Association between CART (Cocaine- and Amphetamine-Regulated Transcript) Gene and Methamphetamine Dependence. Ann N Y Acad Sci, 2006; 1074: 411-417.
406. Masui T, Hashimoto R, Kusumi I, Suzuki K, Tanaka T, Nakagawa S, Suzuki T, Iwata N, Ozaki N, Kato T, Kunugi H, Koyama T. Lithium response and Val66Met polymorphism of the brain-derived neurotrophic factor gene in Japanese patients with bipolar disorder. Psychiatr Genet, 2006; 16: 49-50.
407. Kobayashi H, Hata H, Ujike H, Harano M, Inada T, Komiyama T, Yamada M, Sekine Y, Iwata N, Iyo M, Ozaki N, Itokawa M, Naka M, Ide S, Ikeda K, Numachi Y, Sora I. Association analysis of delta-opioid receptor gene polymorphisms in methamphetamine dependence/psychosis. Am J Med Genet B Neuropsychiatr Genet, 2006; 141: 482-486.
408. Kishi T, Ikeda M, Suzuki T, Kitajima T, Yamanouchi Y, Kinoshita Y, Ozaki N, Iwata N. No association of complexin1 and complexin2 genes with schizophrenia in a Japanese population. Schizophr Res, 2006; 82: 185-189.
409. Kimura H, Ozaki N. Diagnosis and treatment of depression in dialysis patients. Ther Apher Dial, 2006; 10: 328-332.
410. Ikeda M, Iwata N, Suzuki T, Kitajima T, Yamanouchi Y, Kinoshiya Y, Sekine Y, Iyo M, Harano M, Komiyama T, Yamada M, Sora I, Ujike H, Inada T, Ozaki N. Positive association of AKT1 haplotype to Japanese methamphetamine use disorder. Int J Neuropsychopharmacol, 2006; 9: 77-81.
411. Ikeda M, Iwata N, Suzuki T, Kitajima T, Yamanouchi Y, Kinoshita Y, Ozaki N. No association of serotonin transporter gene (SLC6A4) with schizophrenia and bipolar disorder in Japanese patients: association analysis based on linkage disequilibrium. J Neural Transm, 2006; 113: 899-905.
412. Ikeda M, Iwata N, Kitajima T, Suzuki T, Yamanouchi Y, Kinoshita Y, Ozaki N. Positive association of the serotonin 5-HT7 receptor gene with schizophrenia in a Japanese population. Neuropsychopharmacology, 2006; 31: 866-871.
413. Iidaka T, Matsumoto A, Ozaki N, Suzuki T, Iwata N, Yamamoto Y, Okada T, Sadato N. Volume of left amygdala subregion predicted temperamental trait of harm avoidance in female young subjects. A voxel-based morphometry study. Brain Res, 2006; 1125: 85-93.
414. Ide S, Kobayashi H, Ujike H, Ozaki N, Sekine Y, Inada T, Harano M, Komiyama T, Yamada M, Iyo M, Iwata N, Tanaka K, Shen H, Iwahashi K, Itokawa M, Minami M, Satoh M, Ikeda K, Sora I. Linkage disequilibrium and association with methamphetamine dependence/psychosis of mu-opioid receptor gene polymorphisms. Pharmacogenomics J, 2006; 6: 179-188.
415. Hashimoto R, Numakawa T, Ohnishi T, Kumamaru E, Yagasaki Y, Ishimoto T, Mori T, Nemoto K, Adachi N, Izumi A, Chiba S, Noguchi H, Suzuki T, Iwata N, Ozaki N, Taguchi T, Kamiya A, Kosuga A, Tatsumi M, Kamijima K, Weinberger DR, Sawa A, Kunugi H. Impact of the DISC1 Ser704Cys polymorphism on risk for major depression, brain morphology and ERK signaling. Hum Mol Genet, 2006; 15: 3024-3033.
416. Hakamata Y, Iwase M, Iwata H, Kobayashi T, Tamaki T, Nishio M, Kawahara K, Matsuda H, Ozaki N, Honjo S, Inada T. Regional brain cerebral glucose metabolism and temperament: a positron emission tomography study. Neurosci Lett, 2006; 396: 33-37.
417. Aoyama N, Takahashi N, Saito S, Maeno N, Ishihara R, Ji X, Miura H, Ikeda M, Suzuki T, Kitajima T, Yamanouchi Y, Kinoshita Y, Yoshida K, Iwata N, Inada T, Ozaki N. Association study between kynurenine 3-monooxygenase gene and schizophrenia in the Japanese population. Genes Brain Behav, 2006; 5: 364-368.
418. Aoyama N, Takahashi N, Kitaichi K, Ishihara R, Saito S, Maeno N, Ji X, Takagi K, Sekine Y, Iyo M, Harano M, Komiyama T, Yamada M, Sora I, Ujike H, Iwata N, Inada T, Ozaki N. Association between gene polymorphisms of SLC22A3 and methamphetamine use disorder. Alcohol Clin Exp Res, 2006; 30: 1644-1649.
419. Ando T, Komaki G, Naruo T, Okabe K, Takii M, Kawai K, Konjiki F, Takei M, Oka T, Takeuchi K, Masuda A, Ozaki N, Suematsu H, Denda K, Kurokawa N, Itakura K, Yamaguchi C, Kono M, Suzuki T, Nakai Y, Nishizono-Maher A, Koide M, Murakami K, Nagamine K, Tomita Y, Ookuma K, Tomita K, Tonai E, Ooshima A, Ishikawa T, Ichimaru Y. Possible role of preproghrelin gene polymorphisms in susceptibility to bulimia nervosa. Am J Med Genet B Neuropsychiatr Genet, 2006; 141: 929-934.
420. Saito S, Ikeda M, Iwata N, Suzuki T, Kitajima T, Yamanouchi Y, Kinoshita Y, Takahashi N, Inada T, Ozaki N. No association was found between a functional SNP in ZDHHC8 and schizophrenia in a Japanese case-control population. Neurosci Lett, 2005; 374: 21-24.
421. Ohgake S, Hashimoto K, Shimizu E, Koizumi H, Okamura N, Koike K, Matsuzawa D, Sekine Y, Inada T, Ozaki N, Iwata N, Harano M, Komiyama T, Yamada M, Sora I, Ujike H, Shirayama Y, Iyo M. Functional polymorphism of the NQO2 gene is associated with methamphetamine psychosis. Addict Biol, 2005; 10: 145-148.
422. Nishiyama T, Ikeda M, Iwata N, Suzuki T, Kitajima T, Yamanouchi Y, Sekine Y, Iyo M, Harano M, Komiyama T, Yamada M, Sora I, Ujike H, Inada T, Furukawa T, Ozaki N. Haplotype association between GABAA receptor gamma2 subunit gene (GABRG2) and methamphetamine use disorder. Pharmacogenomics J, 2005; 5: 89-95.
423. Morita Y, Ujike H, Tanaka Y, Uchida N, Nomura A, Otani K, Kishimoto M, Morio A, Inada T, Harano M, Komiyama T, Yamada M, Sekine Y, Iwata N, Iyo M, Sora I, Ozaki N. The X-box binding protein 1 (XBP1) gene is not associated with methamphetamine dependence. Neurosci Lett, 2005; 383: 194-198.
424. Morita Y, Ujike H, Tanaka Y, Uchida N, Nomura A, Ohtani K, Kishimoto M, Morio A, Imamura T, Sakai A, Inada T, Harano M, Komiyama T, Yamada M, Sekine Y, Iwata N, Iyo M, Sora I, Ozaki N, Kuroda S. A nonsynonymous polymorphism in the human fatty acid amide hydrolase gene did not associate with either methamphetamine dependence or schizophrenia. Neurosci Lett, 2005; 376: 182-187.
425. Miura H, Qiao H, Kitagami T, Ohta T, Ozaki N. Fluvoxamine, a selective serotonin reuptake inhibitor, suppresses tetrahydrobiopterin levels and dopamine as well as serotonin turnover in the mesoprefrontal system of mice. Psychopharmacology (Berl), 2005; 177: 307-314.
426. Miura H, Qiao H, Kitagami T, Ohta T, Ozaki N. Effects of fluvoxamine on levels of dopamine, serotonin, and their metabolites in the hippocampus elicited by isolation housing and novelty stress in adult rats. Int J Neurosci, 2005; 115: 367-378.
427. Maeno N, Kusunoki K, Kitajima T, Iwata N, Ono Y, Hashimoto S, Imai M, Li L, Kayukawa Y, Ohta T, Ozaki N. Personality of seasonal affective disorder analyzed by Tri-dimensional Personality Questionnaire. J Affect Disord, 2005; 85: 267-273.
428. Kinoshita Y, Suzuki T, Ikeda M, Kitajima T, Yamanouchi Y, Inada T, Yoneda H, Iwata N, Ozaki N. No association with the calcineurin A gamma subunit gene (PPP3CC) haplotype to Japanese schizophrenia. J Neural Transm, 2005; 112: 1255-1262.
429. Ikeda M, Iwata N, Suzuki T, Kitajima T, Yamanouchi Y, Kinoshita Y, Ozaki N. No association of GSK3beta gene (GSK3B) with Japanese schizophrenia. Am J Med Genet B Neuropsychiatr Genet, 2005; 134: 90-92.
430. Ikeda M, Iwata N, Suzuki T, Kitajima T, Yamanouchi Y, Kinoshita Y, Inada T, Ujike H, Ozaki N. Association Analysis of Chromosome 5 GABA(A) Receptor Cluster in Japanese Schizophrenia Patients. Biol Psychiatry, 2005; 58: 440-445.
431. Ikeda M, Iwata N, Suzuki T, Kitajima T, Yamanouchi Y, Kinoshita Y, Inada T, Ozaki N. No association of haplotype-tagging SNPs in TRAR4 with schizophrenia in Japanese patients. Schizophr Res, 2005; 78: 127-130.
432. Iidaka T, Ozaki N, Matsumoto A, Nogawa J, Kinoshita Y, Suzuki T, Iwata N, Yamamoto Y, Okada T, Sadato N. A variant C178T in the regulatory region of the serotonin receptor gene HTR3A modulates neural activation in the human amygdala. J Neurosci, 2005; 25: 6460-6466.
433. Hashimoto T, Hashimoto K, Matsuzawa D, Shimizu E, Sekine Y, Inada T, Ozaki N, Iwata N, Harano M, Komiyama T, Yamada M, Sora I, Ujike H, Iyo M. A functional glutathione S-transferase P1 gene polymorphism is associated with methamphetamine-induced psychosis in Japanese population. Am J Med Genet B Neuropsychiatr Genet, 2005; 135B: 5-9.
434. Hashimoto R, Yoshida M, Ozaki N, Yamanouchi Y, Iwata N, Suzuki T, Kitajima T, Tatsumi M, Kamijima K, Kunugi H. A missense polymorphism (H204R) of a Rho GTPase-activating protein, the chimerin 2 gene, is associated with schizophrenia in men. Schizophr Res, 2005; 73: 383-385.
435. Hashimoto R, Suzuki T, Iwata N, Yamanouchi Y, Kitajima T, Kosuga A, Tatsumi M, Ozaki N, Kamijima K, Kunugi H. Association study of the frizzled-3 (FZD3) gene with schizophrenia and mood disorders. J Neural Transm, 2005; 112: 303-307.
436. Hakamata Y, Takahashi N, Ishihara R, Saito S, Ozaki N, Honjo S, Ono Y, Inada T. No association between monoamine oxidase A promoter polymorphism and personality traits in Japanese females. Neurosci Lett, 2005; 389: 121-123.
437. Furukawa TA, Streiner DL, Azuma H, Higuchi T, Kamijima K, Kanba S, Ozaki N, Aoba A, Murasaki M, Miura S. Cross-cultural equivalence in depression assessment: Japan-Europe-North American study. Acta Psychiatr Scand, 2005; 112: 279-285.
438. Arinami T, Ohtsuki T, Ishiguro H, Ujike H, Tanaka Y, Morita Y, Mineta M, Takeichi M, Yamada S, Imamura A, Ohara K, Shibuya H, Suzuki Y, Muratake T, Kaneko N, Someya T, Inada T, Yoshikawa T, Toyota T, Yamada K, Kojima T, Takahashi S, Osamu O, Shinkai T, Nakamura M, Fukuzako H, Hashiguchi T, Niwa SI, Ueno T, Tachikawa H, Hori T, Asada T, Nanko S, Kunugi H, Hashimoto R, Ozaki N, Iwata N, Harano M, Arai H, Ohnuma T, Kusumi I, Koyama T, Yoneda H, Fukumaki Y, Shibata H, Kaneko S, Higuchi H, Yasui-Furukori N, Numachi Y, Itokawa M, Okazaki Y. Genomewide high-density SNP linkage analysis of 236 Japanese families supports the existence of schizophrenia susceptibility Loci on chromosomes 1p, 14q, and 20p. Am J Hum Genet, 2005; 77: 937-944.
439. Arima M, Shimizu Y, Sowa J, Narita T, Nishi I, Iwata N, Ozaki N, Hashimoto S, Matsunaga K. Psychosomatic analysis of atopic dermatitis using a psychological test. J Dermatol, 2005; 32: 160-168.
440. Takano A, Uchiyama M, Kajimura N, Mishima K, Inoue Y, Kamei Y, Kitajima T, Shibui K, Katoh M, Watanabe T, Hashimotodani Y, Ozeki Y, Hori T, Yamada N, Toyoshima R, Ozaki N, Okawa M, Nagai K, Takahashi K, Isojima Y, Yamauchi T, Ebisawa T. A Missense Variation in Human Casein Kinase I Epsilon Gene that Induces Functional Alteration and Shows an Inverse Association with Circadian Rhythm Sleep Disorders. Neuropsychopharmacology, 2004; 29: 1901-1909.
441. Ozaki N. Pharmacogenetics of antipsychotics. Nagoya J Med Sci, 2004; 67: 1-7.
442. Okada M, Northup J, Ozaki N, Russell J, Linnoila M, Goldman D. Modification of Human 5-HT2C Receptor Function by Cys23Ser, an Abundant, Naturally Occurring Amino Acid Substitution. Mol Psychiatry, 2004; 9: 55-64.
443. Okada M, Goldman D, Linnoila M, Iwata N, Ozaki N, Northup JK. Comparison of G-Protein Selectivity of Human 5-HT2C and 5-HT1A Receptors. Ann N Y Acad Sci, 2004; 1025: 570-577.
444. Numakawa T, Yagasaki Y, Ishimoto T, Okada T, Suzuki T, Iwata N, Ozaki N, Taguchi T, Tatsumi M, Kamijima K, Straub RE, Weinberger DR, Kunugi H, Hashimoto R. Evidence of novel neuronal functions of dysbindin, a susceptibility gene for schizophrenia. Hum Mol Genet, 2004; 13: 2699-2708.
445. Nokura K, Kanbayashi T, Ozeki T, Koga H, Zettsu T, Yamamoto H, Ozaki N, Shimizu T, Kawase T. Hypersomnia, asterixis and cataplexy in association with orexin A-reduced hypothalamic tumor. J Neurol, 2004; 251: 1534-1535.
446. Munakata K, Tanaka M, Mori K, Washizuka S, Yoneda M, Tajima O, Akiyama T, Nanko S, Kunugi H, Tadokoro K, Ozaki N, Inada T, Sakamoto K, Fukunaga T, Iijima Y, Iwata N, Tatsumi M, Yamada K, Yoshikawa T, Kato T. Mitochondrial DNA 3644T-->C mutation associated with bipolar disorder. Genomics, 2004; 84: 1041-1050.
447. Kunugi H, Iijima Y, Tatsumi M, Yoshida M, Hashimoto R, Kato T, Sakamoto K, Fukunaga T, Inada T, Suzuki T, Iwata N, Ozaki N, Yamada K, Yoshikawa T. No association between the Val66Met polymorphism of the brain-derived neurotrophic factor gene and bipolar disorder in a Japanese population: a multicenter study. Biol Psychiatry, 2004; 56: 376-378.
448. Koizumi H, Hashimoto K, Kumakiri C, Shimizu E, Sekine Y, Ozaki N, Inada T, Harano M, Komiyama T, Yamada M, Sora I, Ujike H, Takei N, Iyo M. Association between the glutathione S-transferase M1 gene deletion and female methamphetamine abusers. Am J Med Genet, 2004; 126B: 43-45.
449. Kobayashi H, Ide S, Hasegawa J, Ujike H, Sekine Y, Ozaki N, Inada T, Harano M, Komiyama T, Yamada M, Iyo M, Shen HW, Ikeda K, Soraa I. Study of Association between {alpha}-Synuclein Gene Polymorphism and Methamphetamine Psychosis/Dependence. Ann N Y Acad Sci, 2004; 1025: 325-334.
450. Iwata N, Suzuki T, Ikeda M, Kitajima T, Yamanouchi Y, Inada T, Ozaki N. No Association With the Neuregulin 1 Haplotype to Japanese Schizophrenia. Mol Psychiatry, 2004; 9: 126-127.
451. Iwata N, Inada T, Harano M, Komiyama T, Yamada M, Sekine Y, Iyo M, Sora I, Ujike H, Ozaki N. No association is found between the candidate genes of t-PA/plasminogen system and Japanese methamphetamine-related disorder: a collaborative study by the Japanese Genetics Initiative for Drug Abuse. Ann N Y Acad Sci, 2004; 1025: 34-38.
452. Itoh K, Hashimoto K, Shimizu E, Sekine Y, Ozaki N, Inada T, Harano M, Iwata N, Komiyama T, Yamada M, Sora I, Nakata K, Ujike H, Iyo M. Association study between brain-derived neurotrophic factor gene polymorphisms and methamphetamine abusers in Japan. Am J Med Genet B Neuropsychiatr Genet, 2004; 132B: 70-73.
453. Inada T, Iijima Y, Uchida N, Maeda T, Iwashita S, Ozaki N, Harano M, Komiyama T, Yamada M, Sekine Y, Iyo M, Sora I, Ujikec H. No Association Found between the Type 1 Sigma Receptor Gene Polymorphisms and Methamphetamine Abuse in the Japanese Population: A Collaborative Study by the Japanese Genetics Initiative for Drug Abuse. Ann N Y Acad Sci, 2004; 1025: 27-33.
454. Ikeda M, Iwata N, Suzuki T, Kitajima T, Yamanouchi Y, Kinoshita Y, Inada T, Ozaki N. Association of AKT1 with schizophrenia confirmed in a Japanese population. Biol Psychiatry, 2004; 56: 698-700.
455. Ide S, Kobayashi H, Tanaka K, Ujike H, Sekine Y, Ozaki N, Inada T, Harano M, Komiyama T, Yamada M, Iyo M, Ikeda K, Sora I. Gene polymorphisms of the mu opioid receptor in methamphetamine abusers. Ann N Y Acad Sci, 2004; 1025: 316-324.
456. Hashimoto R, Yoshida M, Ozaki N, Yamanouchi Y, Iwata N, Suzuki T, Kitajima T, Tatsumi M, Kamijima K, Kunugi H. Association analysis of the -308G>A promoter polymorphism of the tumor necrosis factor alpha (TNF-alpha) gene in Japanese patients with schizophrenia. J Neural Transm, 2004; 111: 217-221.
457. Harano M, Uchimura N, Abe H, Ishibashi M, Iida N, Yanagimoto K, Tanaka T, Maeda H, Sora I, Iyo M, Komiyama T, Yamada M, Sekine Y, Inada T, Ozaki N, Ujike H. A Polymorphism of DRD2 Gene and Brain Atrophy in Methamphetamine Psychosis. Ann N Y Acad Sci, 2004; 1025: 307-315.
458. Deng XX, Shibata HH, Ninomiya HH, Tashiro NN, Iwata NN, Ozaki NN, Fukumaki YY. Association study of polymorphisms in the excitatory amino acid transporter 2 gene (SLC1A2) with schizophrenia. BMC Psychiatry, 2004; 4: 21.
459. Yamanouchi Y, Iwata N, Suzuki T, Kitajima T, Ikeda M, Ozaki N. Effect of DRD2, 5-HT2A, and COMT genes on antipsychotic response to risperidone. Pharmacogenomics J, 2003; 3: 356-361.
460. Ujike H, Harano M, Inada T, Yamada M, Komiyama T, Sekine Y, Sora I, Iyo M, Katsu T, Nomura A, Nakata K, Ozaki N. Nine- or fewer repeat alleles in VNTR polymorphism of the dopamine transporter gene is a strong risk factor for prolonged methamphetamine psychosis. Pharmacogenomics J, 2003; 3: 242-247.
461. Tokura T, Murase T, Toriyama T, Totani Y, Negita M, Akaza K, Ozawa H, Nakagawa A, Nakamura S. Asian variant of CD5+ intravascular large B-cell lymphoma with splenic infarction. Intern Med, 2003; 42: 105-109.
462. Suzuki T, Iwata N, Kitamura Y, Kitajima T, Yamanouchi Y, Ikeda M, Nishiyama T, Kamatani N, Ozaki N. Association of a haplotype in the serotonin 5-HT4 receptor gene (HTR4) with Japanese schizophrenia. Am J Med Genet B Neuropsychiatr Genet, 2003; 121: 7-13.
463. Ozaki N, Goldman D, Kaye WH, Plotnicov K, Greenberg BD, Lappalainen J, Rudnick G, Murphy DL. Serotonin transporter missense mutation associated with a complex neuropsychiatric phenotype. Mol Psychiatry, 2003; 8: 933-936.
464. Ozaki N. Psychopharmacogenetics. In: Encyclopedia of Human Genome, edited by DN Cooper. pp. 917-922, 2003, Nature Publishing Group, London, New York and Tokyo.
465. Okada T, Toichi M, Sakihama M. Influences of an anticholinergic antiparkinsonian drug, parkinsonism, and psychotic symptoms on cardiac autonomic function in schizophrenia. J Clin Psychopharmacol, 2003; 23: 441-447.
466. Okada M, Irie S, Sawada M, Urae R, Urae A, Iwata N, Ozaki N, Akazawa K, Nakanishi H. Pepstatin A induces extracellular acidification distinct from aspartic protease inhibition in microglial cell lines. Glia, 2003; 43: 167-174.
467. Noda M, Yasuda S, Okada M, Higashida H, Shimada A, Iwata N, Ozaki N, Nishikawa K, Shirasawa S, Uchida M, Aoki S, Wada K. Recombinant human serotonin 5A receptors stably expressed in C6 glioma cells couple to multiple signal transduction pathways. J Neurochem, 2003; 84: 222-232.
468. Kusunoki K, Kitajima T, Ozaki N. Does quazepam influence sleep and daytime activity in healthy adults? Sleep and Biological Rhythms, 2003; 1: 171-172.
469. Kubota Y, Querel C, Pelion F, Laborit J, Laborit MF, Gorog F, Okada T, Murai T, Sato W, Yoshikawa S, Toichi M, Hayashi T. Facial affect recognition in pre-lingually deaf people with schizophrenia. Schizophr Res, 2003; 61: 265-270.
470. Toichi M, Kamio Y, Okada T, Sakihama M, Youngstrom EA, Findling RL, Yamamoto K. A lack of self-consciousness in autism. Am J Psychiatry, 2002; 159: 1422-1424.
471. Sato W, Kubota Y, Okada T, Murai T, Yoshikawa S, Sengoku A. Seeing happy emotion in fearful and angry faces: qualitative analysis of facial expression recognition in a bilateral amygdala-damaged patient. Cortex, 2002; 38: 727-742.
472. Iwase T, Kajimura N, Uchiyama M, Ebisawa T, Yoshimura K, Kamei Y, Shibui K, Kim K, Kudo Y, Katoh M, Watanabe T, Nakajima T, Ozeki Y, Sugishita M, Hori T, Ikeda M, Toyoshima R, Inoue Y, Yamada N, Mishima K, Nomura M, Ozaki N, Okawa M, Takahashi K, Yamauchi T. Mutation screening of the human Clock gene in circadian rhythm sleep disorders. Psychiatry Res, 2002; 109: 121-128.
473. Hirano S, Sato T, Narita T, Kusunoki K, Ozaki N, Kimura S, Takahashi T, Sakado K, Uehara T. Evaluating the state dependency of the Temperament and Character Inventory dimensions in patients with major depression: a methodological contribution. J Affect Disord, 2002; 69: 31-38.

研究キーワード

精神医学、児童思春期精神医学、精神障害、統合失調症、うつ病、双極性障害、認知症、摂食障害、自閉スペクトラム症、不安症、身体症状症、周産期、産業衛生医学、歯科口腔外科学、がん、臓器移植、心不全、オミックス、ゲノム、遺伝子改変、モデル動物、iPS細胞、神経画像、MRI、NIRS、死後脳、疼痛、自動車運転技能、向精神薬、高齢者、神経性やせ症、妊産婦、ゲノムコホート、エピゲノム

精神医学／精神生物学独自ホームページ

糖鎖生命コア研究所　iGCORE

精神医学　オープンキャンパス

大学院の概要；研究と教育の基本方針

患者・家族のニーズを踏まえ、「日々の臨床疑問の解決」とともに、「病因・病態を解明し、病因・病態に即した診断、治療・予防法の開発」を目指すことが研究の基本方針です。

この目的の実現には、様々な臨床研究、基礎研究が双方向性に共同することが不可欠です。以上を踏まえ、大学院教育においては、多様な志向性を持ち、多面的な観点から研究を行い、臨床と基礎研究の共同を実現させる人材を育成することを目指しております。

具体的には、文献の検索と批判的吟味、研究デザイン、実験ノートの書き方、データ解析、データプレゼンテーション、サイエンティフィックライティングといった研究遂行に必要な基本的ノウハウを身につけ、今後の研究活動の基礎だけではなく、臨床にも活かせる科学的視点を身につけることができるよう指導しています。

"精神医学"、"精神生物学"、"発達・老年精神医学"、"親と子どもの心療学"の各分野に所属しますが、加えて「精神医療学寄附講座」「障害児（者）寄附講座」「睡眠学寄附講座」「脳とこころの研究センター」等とも連動して全体で"精神科ユニット"を構成し、共同指導体制をとっています。
医学部卒業生のみならず、医学部以外の心理学関連専攻の学科、薬学部、保健学部などを卒業した方も歓迎しています。
医学部卒業生と修士課程卒業生対象の博士課程に加えて、医学部以外の卒業生対象の修士課程を募集しています。
研究に専念する一般の博士課程大学院生となる選択肢と、基幹施設或いは連携施設で精神科医としての勤務を続けながら社会人大学院生となる選択肢があります。
医師の場合、所属医局は問いません。ただし少なくとも一年以上の精神科臨床経験を経て、精神障害の実際をある程度知った後、入学していただくのを原則としています。精神科・児童精神科の専門研修プログラム中の医師は、以下の3つのコースから選ぶことが可能です。
(ア) 一般の大学院生を選び、研修プログラム履修を休止して、大学院修了後、研修を再開する。
(イ) 一般の大学院生を選び、基幹施設で診療従事届けを提出し、連携施設での研修状況も勘案して、研修期間に一部カウントする。
(ウ) 社会人大学院生を選び、研修をそのまま継続する。
どのコースを選ぶかは、ご本人の希望を重視して相談に応じます。
大学院生期間中の研究時間の確保：大学院生には基本的に診療上の義務は課していません。各個人の希望でスケジュールを組んでいるので、十分研究時間は確保されています。社会人大学院生として、大学外の施設に所属しながら入学する場合も、できるだけ研究時間を確保するよう各施設の配慮をお願いしています。

名古屋大学大学院医学系研究科･医学部医学科
Nagoya University Graduate School of Medicine.
〒466-8550 名古屋市昭和区鶴舞町65番地　TEL 052-741-2111（代表）