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脳神経病態制御学精神医学/精神生物学

研究室概要

患者・家族のニーズを踏まえ、「日々の臨床疑問の解決」とともに、「病因・病態を解明し、病因・病態に即した診断、治療・予防法の開発」を目指すことが基本方針です。この目的の実現には、様々な臨床研究、基礎研究が双方向性に共同することが不可欠です。
当講座では、統合失調症、うつ病・双極性障害、認知症、摂食障害、自閉スペクトラム症、認知症などの多様な精神障害の診断・治療法や病因・病態を、bio-psycho-social(生物・心理・社会的)な観点から研究しています。

臨床研究

現在利用可能な精神医学的診断・評価法や薬物・心理社会的治療法を、生物・心理・社会的側面から再検討して、特性を明確化し、最適の診断・治療を患者さんに提供することを目標にしています。

  • 対象疾患:統合失調症、うつ病・双極性障害、自閉スペクトラム症、摂食障害、不安症、身体症状症、認知症
疫学研究

精神障害の発症頻度と発症に関与する生物・心理・社会的因子を特定することによって、以下の臨床的活用を目指します。

  • ある集団の診断において「どの疾患の可能性が高いか」
  • 二次予防(早期発見による早期治療)の際に高リスク群を同定
  • 一次予防(発症予防)のため、発症危険因子を同定
  • 実施している具体例
    • 周産期メンタルヘルス:心理社会的要因を加味した妊産婦の気分変動に関するゲノムコホート研究ならびにその児の発達に関するコホート研究
    • 産業衛生:職域のうつ病の疫学的研究と早期発見の手法開発・介入研究
    • 歯科口腔外科患者・がん患者・移植患者・心不全患者に生じるうつ病・不安症の疫学や治療法の研究
    • 摂食障害の疫学:摂食障害の有病率や、発症に関わる心理社会的因子、さらに自閉スペクトラム症との関係を明らかにするための疫学研究
病因・病態解明研究

精神障害の克服に向けて、臨床研究および基礎研究の間で連携を図り、各領域において得られた研究成果を双方向的に照合することで、病因・病態に基づく心理社会的介入法、根本的治療法、予防法の開発と、その臨床試験の実施を目指しています。
具体的にはオミックス解析、ゲノム解析、ゲノム解析結果に基づく遺伝子改変モデル動物の解析、患者由来iPS細胞から樹立したモデル細胞の解析、神経画像(MRI、 NIRS)解析、死後脳解析、を実施しています。

  • 対象疾患:統合失調症、うつ病・双極性障害、摂食障害、自閉スペクトラム症、認知症

研究プロジェクト

1. 頭頸部・膵臓・血液(小児を含む)がん患者の精神医学的側面に関する検討

がん患者は、うつ病の合併率、自殺率が高い点を考慮し、癌患者を対象に抑うつ・不安の発生率を確認しながら、抑うつ・不安に関連する因子を検討して、早期発見・早期介入を目指しています。

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2. 歯科領域の疼痛性疾患の生物心理社会的研究

歯科領域の疼痛を訴え、情動、認知が強く影響されていると判断される患者を対象に前向きコホート研究を行っています。構造化面接(SCID)により診断し、治療前後に疼痛および抑うつの評価を行い、人格傾向・ソーシャルサポート・養育体験を含む心理検査、温冷刺激による疼痛閾値評価および血液を取得し、疼痛刺激応答機構の破綻により誘発されるストレス関連疾患の病態解明から、より良い治療法・診断法の開発を目指しています。

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3. 脳の個人特性を踏まえた運転技能の理解

自動車の運転は、我が国で社会生活を実施する上で重要な要素です。しかし、運転技能に関わる脳機能は明確化されず、精神障害(うつ病、認知症など)患者、向精神薬服用時には、添付文書の記載等により自動車運転が規制されています。そこで、精神障害、向精神薬、加齢が引きおこす運転技能・認知機能の変化を明確化し、添付文書の記載内容の適正化、職場復帰の支援・予測・交通事故防止、認知リハビリテーションの開発、さらに精神疾患患者・高齢者に優しい自動車開発への証左を得ることを目指しています。

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4. 神経性やせ症の神経回路病態解明

神経性やせ症は、死亡率も高く、慢性化する場合も多い、重篤な精神疾患です。しかし、その病態は不明で、有効な治療法もないのが現状です。神経性やせ症の特徴には、自己の身体像イメージが極端になっていることと、摂食に関わる脳と臓器に関わる分子や遺伝因子が関与していることがあげられます。以上に着目して、人格傾向や養育体験などの心理社会的因子とともに、神経画像(MRI、 NIRS)、ゲノム解析を実施して神経回路病態を解明し、より良い治療法の開発を目指しています。

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5. 妊産婦とその児を対象とした前向きゲノムコホート研究

うつ病の発症には遺伝因子と環境因子の両方が関与していますが、環境因子の関与が強く、遺伝環境相互の特定できるゲノムコホート研究が必須と考えられています。妊産婦にはうつ病の発症頻度が高く、母のQOL低下のみならず、子の養育・発達に影響を与えるとして、対応の重要性が強調されています。以上を踏まえ、妊産婦ゲノムコホート研究を実施して、妊産婦のうつ病の実態と発症に関与する因子を明らかにし一次予防の対策を検討しています。また、子供の生物心理社会学的発達状態を確認して、母の妊娠・産後におけるうつ病が、子の発達に与える影響を明確化することを目指しています。

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6. オミックスによる統合失調症、双極性障害、自閉スペクトラム症の診断法開発を目指した研究

統合失調症や双極性障害は発症後、数年で病勢が進行すると考えられていますが、診断に有用な検査法がないため治療的介入が遅れ、その結果、難治化している症例が少なくないのが現状です。また、自閉スペクトラム症は的確な診断と評価がなされず、利用可能な治療・療育が適切に為されていない場合が多く、さらに、現在の治療・療育の効果にも限界があります。そこで、統合失調症・双極性障害・自閉スペクトラム症の病因・病態を特徴づける分子を、オミックス(網羅的ゲノム解析と網羅的発現解析)によって同定し、分子レベルから診断体系を組み替え、早期かつ的確な診断検査法の開発に繋げることを目指しています。

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7. 精神障害克服を目指すゲノム解析を起点とした基礎・臨床連携研究

統合失調症・双極性障害・自閉スペクトラム症は、いずれも長期の治療・療育が必要で、現在、十分な効果をあげることが出来ていない精神障害です。したがって、その病因・病態を解明して、根本的治療法、予防法を開発することが求められています。我々は、ゲノム科学、神経科学、情報科学の手法により、1) 患者ゲノムの解析、2) 1の結果に基づく遺伝子改変モデル動物の解析、1の結果に基づく遺伝子変異を有する患者由来iPS細胞から樹立したモデル中枢神経系細胞の解析、などを実施しています。これらの知見を統合し、基礎研究と臨床研究の連携により、精神障害の克服を目指した研究を実施しています。

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8. ヒト脳組織研究ー臨床診断の精度の向上へむけて

精神障害の臨床的な診断は、臨床症状とMRIなどの神経画像情報や、認知機能検査等の心理検査などを総合して行っています。しかし特に認知症では、現在でも診断を確定するには、脳の病理組織の観察が必須です。したがって、臨床診断の正確さを高めるためには、ヒト脳組織を対象とした神経病理診断の蓄積し、二つの情報を照らし合わせ、統合することが求められます。さらに、統合失調症・気分障害などの精神障害も脳に病態があることは確かであり、病態解明にヒト脳組織の検討は欠かせません。以上の観点から、ヒト脳組織解析による検討を実施しています。

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教員

構成員名役職所属
尾崎 紀夫 教授 大学院医学系研究科 総合医学専攻
入谷 修司 教授 大学院医学系研究科 寄附講座(医)
稲田 俊也 准教授 大学院医学系研究科 総合医学専攻
岡田 俊 准教授 医学部附属病院 親と子どもの心療科
Branko Aleksic 特任准教授 国際機構
木村 宏之 講師 大学院医学系研究科 総合医学専攻
藤城 弘樹 講師 大学院医学系研究科 寄附講座(医)
岩本 邦弘 講師 大学院医学系研究科 総合医学専攻
田中 聡 助教 医学部附属病院 精神科
小川 しおり 助教 医学部附属病院 精神科
徳倉 達也 助教 医学部附属病院 精神科
石塚 佳奈子 助教 医学部附属病院 親と子どもの心療科
森川 真子 助教 大学院医学系研究科 寄附講座(医)
木村 大樹 助教 大学院医学系研究科 寄附講座(医)
今枝 美穂 病院助教 医学部附属病院 化学療法部
鳥井 洋太 病院助教 医学部附属病院 卒後臨床研修・キャリア形成支援センター
山本 真江里 病院助教 医学部附属病院 精神科
小笠原 一能 特任助教 医学部附属病院 
久島 周 特任助教 高等研究院
森 大輔 特任准教授 脳とこころの研究センター 研究開発部門
河野 直子 特任講師 未来社会創造機構 モビリティ領域
宮田 聖子 特任助教 大学院医学系研究科 附属医学教育研究支援センター
有岡 祐子 特任助教 医学部附属病院 先端医療・臨床研究支援センター
辻村 啓太 特任助教 大学院医学系研究科 総合医学専攻

研究実績

  • 2016年
    1. Umeda K, Iritani S, Fujishiro H, Sekiguchi H, Torii Y, Habuchi C, Kuroda K, Kaibuchi K, Ozaki N. Immunohistochemical Evaluation of the GABAergic Neuronal System in the Prefrontal Cortex of a DISC1 Knockout Mouse Model of Schizophrenia. Synapse, in press.
    2. Ukai K, Fujishiro H, Watanabe M, Kosaka K, Ozaki N. Similarity of symptoms between transient epileptic amnesia and Lewy body disease. Psychogeriatrics, in press.
    3. Ukai K, Fujishiro H, Ozaki N. Effectiveness of low-dose pregabalin in three patients with Lewy body disease and central neuropathic pain. Psychogeriatrics, in press.
    4. Ukai K, Fujishiro H, Iritani S, Ozaki N. Long-term efficacy of donepezil for relapse of visual hallucinations in patients with dementia with Lewy bodies. Psychogeriatrics, in press.
    5. Torii Y, Iritani S, Fujishiro H, Sekiguchi H, Habuchi C, Umeda K, Matsunaga S, Mimuro M, Ozaki N, Yoshida M, Fujita K. An autopsy case of cortical superficial siderosis with persistent abnormal behavior. Neuropathology, in press.
    6. Sekiguchi H, Moriwaki M, Iritani S, Habuchi C, Torii Y, Umeda K, Fujishiro H, Yoshida M, Fujita K. An autopsy case of dementia with Lewy bodies clinically diagnosed to have a behavioral variant of frontotemporal dementia. Clin Neuropathol, in press.
    7. Okada N, Fukunaga M, Yamashita F, Koshiyama D, Yamamori H, Ohi K, Yasuda Y, Fujimoto M, Watanabe Y, Yahata N, Nemoto K, Hibar DP, van Erp TG, Fujino H, Isobe M, Isomura S, Natsubori T, Narita H, Hashimoto N, Miyata J, Koike S, Takahashi T, Yamasue H, Matsuo K, Onitsuka T, Iidaka T, Kawasaki Y, Yoshimura R, Watanabe Y, Suzuki M, Turner JA, Takeda M, Thompson PM, Ozaki N, Kasai K, Hashimoto R. Abnormal asymmetries in subcortical brain volume in schizophrenia. Mol Psychiatry, in press.
    8. Munechika T, Fujishiro H, Okuda M, Iwamoto K, Torii Y, Iritani S, Ozaki N. Rapid eye movement sleep without atonia may help diagnose Lewy body disease in middle-aged and older patients with somatic symptom disorder. Psychogeriatrics, in press.
    9. Miyashita M, Watanabe T, Ichikawa T, Toriumi K, Horiuchi Y, Kobori A, Kushima I, Hashimoto R, Fukumoto M, Koike S, Ujike H, Arinami T, Tatebayashi Y, Kasai K, Takeda M, Ozaki N, Okazaki Y, Yoshikawa T, Amano N, Washizuka S, Yamamoto H, Miyata T, Itokawa M, Yamamoto Y, Arai M. The regulation of soluble receptor for AGEs contributes to carbonyl stress in schizophrenia. Biochem Biophys Res Commun, in press.
    10. Kushima I, Aleksic B, Nakatochi M, Shimamura T, Shiino T, Yoshimi A, Kimura H, Takasaki Y, Wang C, Xing J, Ishizuka K, Oya-Ito T, Nakamura Y, Arioka Y, Maeda T, Yamamoto M, Yoshida M, Noma H, Hamada S, Morikawa M, Uno Y, Okada T, Iidaka T, Iritani S, Yamamoto T, Miyashita M, Kobori A, Arai M, Itokawa M, Cheng MC, Chuang YA, Chen CH, Suzuki M, Takahashi T, Hashimoto R, Yamamori H, Yasuda Y, Watanabe Y, Nunokawa A, Someya T, Ikeda M, Toyota T, Yoshikawa T, Numata S, Ohmori T, Kunimoto S, Mori D, Iwata N, Ozaki N. High-resolution copy number variation analysis of schizophrenia in Japan. Mol Psychiatry, in press.
    11. Kuroki T, Ishitobi M, Kamio Y, Sugihara G, Murai T, Motomura K, Ogasawara K, Kimura H, Aleksic B, Ozaki N, Nakao T, Yamada K, Yoshiuchi K, Kiriike N, Ishikawa T, Kubo C, Matsunaga C, Miyata H, Asada T, Kanba S. Current Viewpoints on DSM-5 in Japan. Psychiatry Clin Neurosci, in press.
    12. Kimura H, Wang C, Ishizuka K, Xing J, Takasaki Y, Kushima I, Aleksic B, Uno Y, Okada T, Ikeda M, Mori D, Inada T, Iwata N, Ozaki N. Identification of a rare variant in CHD8 that contributes to schizophrenia and autism spectrum disorder susceptibility. Schizophr Res, in press.
    13. Kato K, Miyata S, Ando M, Matsuoka H, Yasuma F, Iwamoto K, Kawano N, Banno M, Ozaki N, Noda A. Influence of sleep duration on cortical oxygenation in elderly individuals. Psychiatry Clin Neurosci, in press.
    14. Fujishiro H, Okuda M, Iwamoto K, Miyata S, Otake H, Noda A, Iritani S, Ozaki N. REM sleep without atonia in middle-aged and older psychiatric patients and Lewy body disease: a case series. Int J Geriatr Psychiatry, in press.
    15. Fujioi J, Iwamoto K, Banno M, Kikuchi T, Aleksic B, Ozaki N. Effect of Adjunctive Aripiprazole on Sexual Dysfunction in Schizophrenia: A Preliminary Open-Label Study. Pharmacopsychiatry, in press.
    16. Yoshida K, Go Y, Kushima I, Toyoda A, Fujiyama A, Imai H, Saito N, Iriki A, Ozaki N, Isoda M. Single-neuron and genetic correlates of autistic behavior in macaque. Sci Adv, 2016; 2: e1600558.
    17. Yano M, Kawano N, Tanaka S, Kohmura K, Katayama H, Nishioka K, Ozaki N. Dysfunction of response inhibition in eating disorders. J Clin Exp Neuropsychol, 2016; 38: 700-708.
    18. Xing J, Kimura H, Wang C, Ishizuka K, Kushima I, Arioka Y, Yoshimi A, Nakamura Y, Shiino T, Oya-Ito T, Takasaki Y, Uno Y, Okada T, Iidaka T, Aleksic B, Mori D, Ozaki N. Resequencing and Association Analysis of Six PSD-95-Related Genes as Possible Susceptibility Genes for Schizophrenia and Autism Spectrum Disorders. Sci Rep, 2016; 6: 27491.
    19. Tsujii N, Saito T, Izumoto Y, Usami M, Okada T, Negoro H, Iida J. Experiences with Patient Refusal of Off-Label Prescribing of Psychotropic Medications to Children and Adolescents in Japan. J Child Adolesc Psychopharmacol, 2016; 26: 642-645.
    20. Takasaki Y, Koide T, Wang C, Kimura H, Xing J, Kushima I, Ishizuka K, Mori D, Sekiguchi M, Ikeda M, Aizawa M, Tsurumaru N, Iwayama Y, Yoshimi A, Arioka Y, Yoshida M, Noma H, Oya-Ito T, Nakamura Y, Kunimoto S, Aleksic B, Uno Y, Okada T, Ujike H, Egawa J, Kuwabara H, Someya T, Yoshikawa T, Iwata N, Ozaki N. Mutation screening of GRIN2B in schizophrenia and autism spectrum disorder in a Japanese population. Sci Rep, 2016; 6: 33311.
    21. Sugimoto H, Kawashima H, Ohno E, Hayashi D, Kuwahara T, Morishima T, Kawai M, Suhara H, Takeyama T, Yamamura T, Funasaka K, Nakamura M, Miyahara R, Watanabe O, Ishigami M, Suzuki M, Kimura H, Ozaki N, Hashimoto S, Goto H, Hirooka Y. The prognostic factors and trajectory of HRQOL in patients with pancreatic cancer who received psychiatric intervention. J Gastroenterol Hepatol, 2016; 31: 685-690.
    22. Ohara M, Okada T, Kubota C, Nakamura Y, Shiino T, Aleksic B, Morikawa M, Yamauchi A, Uno Y, Murase S, Goto S, Kanai A, Masuda T, Ozaki N. Validation and factor analysis of mother-infant bonding questionnaire in pregnant and postpartum women in Japan. BMC Psychiatry, 2016; 16: 212.
    23. Nakazawa T, Hashimoto R, Sakoori K, Sugaya Y, Tanimura A, Hashimotodani Y, Ohi K, Yamamori H, Yasuda Y, Umeda-Yano S, Kiyama Y, Konno K, Inoue T, Yokoyama K, Inoue T, Numata S, Ohnuma T, Iwata N, Ozaki N, Hashimoto H, Watanabe M, Manabe T, Yamamoto T, Takeda M, Kano M. Corrigendum: Emerging roles of ARHGAP33 in intracellular trafficking of TrkB and pathophysiology of neuropsychiatric disorders. Nat Commun, 2016; 7: 11466.
    24. Nakazawa T, Hashimoto R, Sakoori K, Sugaya Y, Tanimura A, Hashimotodani Y, Ohi K, Yamamori H, Yasuda Y, Umeda-Yano S, Kiyama Y, Konno K, Inoue T, Yokoyama K, Inoue T, Numata S, Ohnuma T, Iwata N, Ozaki N, Hashimoto H, Watanabe M, Manabe T, Yamamoto T, Takeda M, Kano M. Emerging roles of ARHGAP33 in intracellular trafficking of TrkB and pathophysiology of neuropsychiatric disorders. Nat Commun, 2016; 7: 10594.
    25. Isles AR, Ingason A, Lowther C, Walters J, Gawlick M, Stober G, Rees E, Martin J, Little RB, Potter H, Georgieva L, Pizzo L, Ozaki N, Aleksic B, Kushima I, Ikeda M, Iwata N, Levinson DF, Gejman PV, Shi J, Sanders AR, Duan J, Willis J, Sisodiya S, Costain G, Werge TM, Degenhardt F, Giegling I, Rujescu D, Hreidarsson SJ, Saemundsen E, Ahn JW, Ogilvie C, Girirajan SD, Stefansson H, Stefansson K, O'Donovan MC, Owen MJ, Bassett A, Kirov G. Parental Origin of Interstitial Duplications at 15q11.2-q13.3 in Schizophrenia and Neurodevelopmental Disorders. PLoS Genet, 2016; 12: e1005993.
    26. Ishizuka K, Kimura H, Wang C, Xing J, Kushima I, Arioka Y, Oya-Ito T, Uno Y, Okada T, Mori D, Aleksic B, Ozaki N. Investigation of Rare Single-Nucleotide PCDH15 Variants in Schizophrenia and Autism Spectrum Disorders. PLoS One, 2016; 11: e0153224.
    27. Iritani S, Sekiguchi H, Habuchi C, Torii Y, Kuroda K, Kaibuchi K, Ozaki N. Catecholaminergic neuronal network dysfunction in the frontal lobe of a genetic mouse model of schizophrenia. Acta Neuropsychiatr, 2016; 28: 117-123.
    28. Hou L, Heilbronner U, Degenhardt F, Adli M, Akiyama K, Akula N, Ardau R, Arias B, Backlund L, Banzato CE, Benabarre A, Bengesser S, Bhattacharjee AK, Biernacka JM, Birner A, Brichant-Petitjean C, Bui ET, Cervantes P, Chen GB, Chen HC, Chillotti C, Cichon S, Clark SR, Colom F, Cousins DA, Cruceanu C, Czerski PM, Dantas CR, Dayer A, Etain B, Falkai P, Forstner AJ, Frisen L, Fullerton JM, Gard S, Garnham JS, Goes FS, Grof P, Gruber O, Hashimoto R, Hauser J, Herms S, Hoffmann P, Hofmann A, Jamain S, Jimenez E, Kahn JP, Kassem L, Kittel-Schneider S, Kliwicki S, Konig B, Kusumi I, Lackner N, Laje G, Landen M, Lavebratt C, Leboyer M, Leckband SG, Jaramillo CA, MacQueen G, Manchia M, Martinsson L, Mattheisen M, McCarthy MJ, McElroy SL, Mitjans M, Mondimore FM, Monteleone P, Nievergelt CM, Nothen MM, Osby U, Ozaki N, Perlis RH, Pfennig A, Reich-Erkelenz D, Rouleau GA, Schofield PR, Schubert KO, Schweizer BW, Seemuller F, Severino G, Shekhtman T, Shilling PD, Shimoda K, Simhandl C, Slaney CM, Smoller JW, Squassina A, Stamm T, Stopkova P, Tighe SK, Tortorella A, Turecki G, Volkert J, Witt S, Wright A, Young LT, Zandi PP, Potash JB, DePaulo JR, Bauer M, Reininghaus EZ, Novak T, Aubry JM, Maj M, Baune BT, Mitchell PB, Vieta E, Frye MA, Rybakowski JK, Kuo PH, Kato T, Grigoroiu-Serbanescu M, Reif A, Del Zompo M, Bellivier F, Schalling M, Wray NR, Kelsoe JR, Alda M, Rietschel M, McMahon FJ, Schulze TG. Genetic variants associated with response to lithium treatment in bipolar disorder: a genome-wide association study. Lancet, 2016; 387: 1085-1093.
    29. Higashiyama R, Ohnuma T, Takebayashi Y, Hanzawa R, Shibata N, Yamamori H, Yasuda Y, Kushima I, Aleksic B, Kondo K, Ikeda M, Hashimoto R, Iwata N, Ozaki N, Arai H. Association of copy number polymorphisms at the promoter and translated region of COMT with Japanese patients with schizophrenia. Am J Med Genet B Neuropsychiatr Genet, 2016; 171: 447-457.
    30. Goto A, Mouri A, Nagai T, Yoshimi A, Ukigai M, Tsubai T, Hida H, Ozaki N, Noda Y. Involvement of the histamine H4 receptor in clozapine-induced hematopoietic toxicity: Vulnerability under granulocytic differentiation of HL-60 cells. Toxicol Appl Pharmacol, 2016; 306: 8-16.
    31. Fujishiro H, Iritani S, Sekiguchi H, Habuchi C, Torii Y, Matsunaga S, Ozaki N, Yoshida M, Fujita K. Hypochondriasis as an early manifestation of dementia with Lewy bodies: an autopsied case report. Psychogeriatrics, 2016; 16: 139-144.
  • 2015年
    1. Yamamoto M, Kushima I, Kimura H, Hayashi A, Kawano N, Aleksic B, Iidaka T, Ozaki N. White matter microstructure between the pre-SMA and the cingulum bundle is related to response conflict in healthy subjects. Brain Behav, 2015; 5: e00375.
    2. Wang C, Aleksic B, Ozaki N. Glia-related genes and their contribution to schizophrenia. Psychiatry Clin Neurosci, 2015; 69: 448-461.
    3. Usami M, Iwadare Y, Watanabe K, Ushijima H, Kodaira M, Okada T, Sasayama D, Sugiyama N, Saito K. A case-control study of the difficulties in daily functioning experienced by children with depressive disorder. J Affect Disord, 2015; 179: 167-174.
    4. Uno Y, Uchiyama T, Kurosawa M, Aleksic B, Ozaki N. Early exposure to the combined measles-mumps-rubella vaccine and thimerosal-containing vaccines and risk of autism spectrum disorder. Vaccine, 2015; 33: 2511-2516.
    5. Uno K, Nishizawa D, Seo S, Takayama K, Matsumura S, Sakai N, Ohi K, Nabeshima T, Hashimoto R, Ozaki N, Hasegawa J, Sato N, Tanioka F, Sugimura H, Fukuda KI, Higuchi S, Ujike H, Inada T, Iwata N, Sora I, Iyo M, Kondo N, Won MJ, Naruse N, Uehara-Aoyama K, Itokawa M, Yamada M, Ikeda K, Miyamoto Y, Nitta A. The Piccolo Intronic Single Nucleotide Polymorphism rs13438494 Regulates Dopamine and Serotonin Uptake and Shows Associations with Dependence-Like Behavior in Genomic Association Study. Curr Mol Med, 2015; 15: 265-274.
    6. Tokura T, Kimura H, Ito M, Nagashima W, Sato N, Kimura Y, Arao M, Aleksic B, Yoshida K, Kurita K, Ozaki N. Temperament and character profiles of patients with burning mouth syndrome. J Psychosom Res, 2015; 78: 495-498.
    7. Tanaka S, Yoshida K, Katayama H, Kohmura K, Kawano N, Imaeda M, Kato S, Ando M, Aleksic B, Nishioka K, Ozaki N. Association of Beck Depression Inventory score and Temperament and Character Inventory-125 in patients with eating disorders and severe malnutrition. J Eat Disord, 2015; 3: 36.
    8. Takahashi T, Nakamura M, Nakamura Y, Aleksic B, Kido M, Sasabayashi D, Takayanagi Y, Furuichi A, Nishikawa Y, Noguchi K, Ozaki N, Suzuki M. The Disrupted-in-Schizophrenia-1 Ser704Cys polymorphism and brain neurodevelopmental markers in schizophrenia and healthy subjects. Prog Neuropsychopharmacol Biol Psychiatry, 2015; 56: 11-17.
    9. Ozaki N, Otsubo T, Kato M, Higuchi T, Ono H, Kamijima K, Group AS. Efficacy of aripiprazole augmentation in Japanese patients with major depressive disorder: A subgroup analysis and Montgomery-Asberg Depression Rating Scale and Hamilton Rating Scale for Depression item analyses of the Aripiprazole Depression Multicenter Efficacy study. Psychiatry Clin Neurosci, 2015; 69: 34-42.
    10. Okada T, Ozaki N. What is the nature of the autism 'spectrum'? Psychiatry Clin Neurosci, 2015; 69: 129-130.
    11. Okada T, Kubota Y, Sato W, Murai T, Pellion F, Gorog F. Common impairments of emotional facial expression recognition in schizophrenia across French and Japanese cultures. Front Psychol, 2015; 6: 1018.
    12. Noda A, Miyaji M, Wakuda Y, Hara Y, Yasuma F, Fukuda T, Iwamoto K, Ozaki N. Simultaneous Measurement of Heart Rate Variability and Blinking Duration to Predict Sleep Onset and Drowsiness in Drivers. J Sleep Disord Ther, 2015; 4: 213.
    13. Nishizawa D, Kasai S, Hasegawa J, Sato N, Yamada H, Tanioka F, Nagashima M, Katoh R, Satoh Y, Tagami M, Ujike H, Ozaki N, Inada T, Iwata N, Sora I, Iyo M, Yamada M, Kondo N, Won MJ, Naruse N, Uehara-Aoyama K, Itokawa M, Ohi K, Hashimoto R, Tanisawa K, Arai T, Mori S, Sawabe M, Naka-Mieno M, Yamada Y, Yamada M, Sato N, Muramatsu M, Tanaka M, Irukayama-Tomobe Y, Saito YC, Sakurai T, Hayashida M, Sugimura H, Ikeda K. Associations between the orexin (hypocretin) receptor 2 gene polymorphism Val308Ile and nicotine dependence in genome-wide and subsequent association studies. Mol Brain, 2015; 8: 50.
    14. Morikawa M, Okada T, Ando M, Aleksic B, Kunimoto S, Nakamura Y, Kubota C, Uno Y, Tamaji A, Hayakawa N, Furumura K, Shiino T, Morita T, Ishikawa N, Ohoka H, Usui H, Banno N, Murase S, Goto S, Kanai A, Masuda T, Ozaki N. Relationship between social support during pregnancy and postpartum depressive state: a prospective cohort study. Sci Rep, 2015; 5: 10520.
    15. Miyata S, Noda A, Iwamoto K, Kawano N, Banno M, Tsuruta Y, Noda Y, Ozaki N. Impaired cortical oxygenation is related to mood disturbance resulting from three nights of sleep restriction. Sleep and Biological Rhythms, 2015; 13: 387-394.
    16. Miyata A, Iwamoto K, Kawano N, Kohmura K, Yamamoto M, Aleksic B, Ebe K, Noda A, Noda Y, Iritani S, Ozaki N. The effects of acute treatment with ramelteon, triazolam, and placebo on driving performance, cognitive function, and equilibrium function in healthy volunteers. Psychopharmacology (Berl), 2015; 232: 2127-2137.
    17. Kimura H, Tsuboi D, Wang C, Kushima I, Koide T, Ikeda M, Iwayama Y, Toyota T, Yamamoto N, Kunimoto S, Nakamura Y, Yoshimi A, Banno M, Xing J, Takasaki Y, Yoshida M, Aleksic B, Uno Y, Okada T, Iidaka T, Inada T, Suzuki M, Ujike H, Kunugi H, Kato T, Yoshikawa T, Iwata N, Kaibuchi K, Ozaki N. Identification of Rare, Single-Nucleotide Mutations in NDE1 and Their Contributions to Schizophrenia Susceptibility. Schizophr Bull, 2015; 41: 744-753.
    18. Kimura H, Tanaka S, Kushima I, Koide T, Banno M, Kikuchi T, Nakamura Y, Shiino T, Yoshimi A, Oya-Ito T, Xing J, Wang C, Takasaki Y, Aleksic B, Okada T, Ikeda M, Inada T, Iidaka T, Iwata N, Ozaki N. Association study of BCL9 gene polymorphism rs583583 with schizophrenia and negative symptoms in Japanese population. Sci Rep, 2015; 5: 15705.
    19. Kimura H, Onishi Y, Sunada S, Kishi S, Suzuki N, Tsuboi C, Yamaguchi N, Imai H, Kamei H, Fujisiro H, Okada T, Ishigami M, Ogura Y, Kiuchi T, Ozaki N. Postoperative Psychiatric Complications in Living Liver Donors. Transplant Proc, 2015; 47: 1860-1865.
    20. Ito M, Tokura T, Yoshida K, Nagashima W, Kimura H, Umemura E, Tachibana M, Miyauchi T, Kobayashi Y, Arao M, Ozaki N, Kurita K. Five Patients With Burning Mouth Syndrome in Whom an Antidepressant (Serotonin-Noradrenaline Reuptake Inhibitor) Was Not Effective, but Pregabalin Markedly Relieved Pain. Clin Neuropharmacol, 2015; 38: 158-161.
    21. Inoue E, Watanabe Y, Xing J, Kushima I, Egawa J, Okuda S, Hoya S, Okada T, Uno Y, Ishizuka K, Sugimoto A, Igeta H, Nunokawa A, Sugiyama T, Ozaki N, Someya T. Resequencing and Association Analysis of CLN8 with Autism Spectrum Disorder in a Japanese Population. PLoS One, 2015; 10: e0144624.
    22. Ikeda M, Yoshimura R, Hashimoto R, Kondo K, Saito T, Shimasaki A, Ohi K, Tochigi M, Kawamura Y, Nishida N, Miyagawa T, Sasaki T, Tokunaga K, Kasai K, Takeda M, Nakamura J, Ozaki N, Iwata N. Genetic Overlap Between Antipsychotic Response and Susceptibility to Schizophrenia. J Clin Psychopharmacol, 2015; 35: 85-88.
    23. Hida H, Mouri A, Mori K, Matsumoto Y, Seki T, Taniguchi M, Yamada K, Iwamoto K, Ozaki N, Nabeshima T, Noda Y. Blonanserin Ameliorates Phencyclidine-Induced Visual-Recognition Memory Deficits: the Complex Mechanism of Blonanserin Action Involving D3-5-HT2A and D1-NMDA Receptors in the mPFC. Neuropsychopharmacology, 2015; 40: 601-613.
    24. Hayakawa N, Okada T, Nomura K, Tsukada T, Nakamura M. Is high job control a risk factor for poor quality of life in workers with high autism spectrum tendencies? A cross-sectional survey at a factory in Japan. J Occup Health, 2015; 57: 419-426.
    25. Hatano M, Ikeda M, Kondo K, Saito T, Shimasaki A, Esaki K, Umene-Nakano W, Yoshimura R, Nakamura J, Ozaki N, Iwata N. No support for replication of the genetic variants identified by a recent mega-analysis of the treatment response to antidepressants. J Hum Genet, 2015; 60: 343-344.
    26. Fujishiro H, Iritani S, Hattori M, Sekiguchi H, Matsunaga S, Habuchi C, Torii Y, Umeda K, Ozaki N, Yoshida M, Fujita K. Autopsy-confirmed hippocampal-sparing Alzheimer's disease with delusional jealousy as initial manifestation. Psychogeriatrics, 2015; 15: 198-203.
    27. Egawa J, Watanabe Y, Wang C, Inoue E, Sugimoto A, Sugiyama T, Igeta H, Nunokawa A, Shibuya M, Kushima I, Orime N, Hayashi T, Okada T, Uno Y, Ozaki N, Someya T. Novel Rare Missense Variations and Risk of Autism Spectrum Disorder: Whole-Exome Sequencing in Two Families with Affected Siblings and a Two-Stage Follow-Up Study in a Japanese Population. PLoS One, 2015; 10: e0119413.
  • 2014年
    1. Xing J, Wang C, Kimura H, Takasaki Y, Kunimoto S, Yoshimi A, Nakamura Y, Koide T, Banno M, Kushima I, Uno Y, Okada T, Aleksic B, Ikeda M, Iwata N, Ozaki N. Resequencing and Association Analysis of PTPRA, a Possible Susceptibility Gene for Schizophrenia and Autism Spectrum Disorders. PLoS One, 2014; 9: e112531.
    2. Wang C, Koide T, Kimura H, Kunimoto S, Yoshimi A, Nakamura Y, Kushima I, Banno M, Kawano N, Takasaki Y, Xing J, Noda Y, Mouri A, Aleksic B, Ikeda M, Okada T, Iidaka T, Inada T, Iwata N, Ozaki N. Novel rare variants in F-box protein 45 (FBXO45) in schizophrenia. Schizophr Res, 2014; 157: 149-156.
    3. Uno Y, Mizukami H, Ando M, Yukihiro R, Iwasaki Y, Ozaki N. Reliability and Validity of the New Tanaka B Intelligence Scale Scores: A Group Intelligence Test. PLoS One, 2014; 9: e100262.
    4. Takahashi T, Nakamura Y, Nakamura Y, Aleksic B, Takayanagi Y, Furuichi A, Kido M, Nakamura M, Sasabayashi D, Ikeda M, Noguchi K, Kaibuchi K, Iwata N, Ozaki N, Suzuki M. The polymorphism of YWHAE, a gene encoding 14-3-3epsilon, and orbitofrontal sulcogyral pattern in patients with schizophrenia and healthy subjects. Prog Neuropsychopharmacol Biol Psychiatry, 2014; 51C: 166-171.
    5. Takahashi T, Nakamura M, Nakamura Y, Aleksic B, Kido M, Sasabayashi D, Takayanagi Y, Furuichi A, Nishikawa Y, Noguchi K, Ozaki N, Suzuki M. The Disrupted-in-Schizophrenia-1 Ser704Cys polymorphism and brain neurodevelopmental markers in schizophrenia and healthy subjects. Prog Neuropsychopharmacol Biol Psychiatry, 2014; 56C: 11-17.
    6. Shishido E, Aleksic B, Ozaki N. Copy-number variation in the pathogenesis of autism spectrum disorder. Psychiatry Clin Neurosci, 2014; 68: 85-95.
    7. Saito T, Kondo K, Iwayama Y, Shimasaki A, Aleksic B, Yamada K, Toyota T, Hattori E, Esaki K, Ujike H, Inada T, Kunugi H, Kato T, Yoshikawa T, Ozaki N, Ikeda M, Iwata N. Replication and cross-phenotype study based upon schizophrenia GWASs data in the Japanese population: Support for association of MHC region with psychosis. Am J Med Genet B Neuropsychiatr Genet, 2014; 165: 421-427.
    8. Ohoka H, Koide T, Goto S, Murase S, Kanai A, Masuda T, Aleksic B, Ishikawa N, Furumura K, Ozaki N. Effects of maternal depressive symptomatology during pregnancy and the postpartum period on infant-mother attachment. Psychiatry Clin Neurosci, 2014; 68: 631-639.
    9. Nishizawa D, Fukuda K, Kasai S, Hasegawa J, Aoki Y, Nishi A, Saita N, Koukita Y, Nagashima M, Katoh R, Satoh Y, Tagami M, Higuchi S, Ujike H, Ozaki N, Inada T, Iwata N, Sora I, Iyo M, Kondo N, Won MJ, Naruse N, Uehara-Aoyama K, Itokawa M, Koga M, Arinami T, Kaneko Y, Hayashida M, Ikeda K. Genome-wide association study identifies a potent locus associated with human opioid sensitivity. Mol Psychiatry, 2014; 19: 55-62.
    10. Morita T, Senzaki K, Ishihara R, Umeda K, Iwata N, Nagai T, Hida H, Nabeshima T, Yukawa K, Ozaki N, Noda Y. Plasma dehydroepiandrosterone sulfate levels in patients with major depressive disorder correlate with remission during treatment with antidepressants. Hum Psychopharmacol, 2014; 29: 280-286.
    11. Miyata S, Noda A, Iwamoto K, Takahashi M, Hara Y, Kojima J, Iidaka T, Ozaki N. The effects of acute treatment with paroxetine, amitriptyline, and placebo on the equilibrium function in healthy subjects: A double-blind crossover trial. Int J Psychiatry Clin Pract, 2014; 18: 32-36.
    12. Miyashita M, Arai M, Yuzawa H, Niizato K, Oshima K, Kushima I, Hashimoto R, Fukumoto M, Koike S, Toyota T, Ujike H, Arinami T, Kasai K, Takeda M, Ozaki N, Okazaki Y, Yoshikawa T, Amano N, Miyata T, Itokawa M. Replication of enhanced carbonyl stress in a subpopulation of schizophrenia. Psychiatry Clin Neurosci, 2014; 68: 83-84.
    13. Kubota C, Okada T, Aleksic B, Nakamura Y, Kunimoto S, Morikawa M, Shiino T, Tamaji A, Ohoka H, Banno N, Morita T, Murase S, Goto S, Kanai A, Masuda T, Ando M, Ozaki N. Factor structure of the Japanese version of the edinburgh postnatal depression scale in the postpartum period. PLoS One, 2014; 9: e103941.
    14. Kido M, Nakamura Y, Nemoto K, Takahashi T, Aleksic B, Furuichi A, Nakamura Y, Ikeda M, Noguchi K, Kaibuchi K, Iwata N, Ozaki N, Suzuki M. The Polymorphism of YWHAE, a Gene Encoding 14-3-3Epsilon, and Brain Morphology in Schizophrenia: A Voxel-Based Morphometric Study. PLoS One, 2014; 9: e103571.
    15. Katayama H, Kohmura K, Tanaka S, Imaeda M, Kawano N, Noda Y, Nishioka K, Ando M, Aleksic B, Iidaka T, Ozaki N. Social insecurity in relation to orbitofrontal activity in patients with eating disorders: a near-infrared spectroscopy study. BMC Psychiatry, 2014; 14: 173.
    16. Kajio Y, Kondo K, Saito T, Iwayama Y, Aleksic B, Yamada K, Toyota T, Hattori E, Ujike H, Inada T, Kunugi H, Kato T, Yoshikawa T, Ozaki N, Ikeda M, Iwata N. Genetic association study between the detected risk variants based upon type II diabetes GWAS and psychotic disorders in the Japanese population. J Hum Genet, 2014; 59: 54-56.
    17. Hida H, Mouri A, Ando Y, Mori K, Mamiya T, Iwamoto K, Ozaki N, Yamada K, Nabeshima T, Noda Y. Combination of neonatal PolyI:C and adolescent phencyclidine treatments is required to induce behavioral abnormalities with overexpression of GLAST in adult mice. Behav Brain Res, 2014; 258: 34-42.
    18. Hashimoto R, Ikeda M, Yamashita F, Ohi K, Yamamori H, Yasuda Y, Fujimoto M, Fukunaga M, Nemoto K, Takahashi T, Tochigi M, Onitsuka T, Yamasue H, Matsuo K, Iidaka T, Iwata N, Suzuki M, Takeda M, Kasai K, Ozaki N. Common variants at 1p36 are associated with superior frontal gyrus volume. Transl Psychiatry, 2014; 4: e472.
    19. De Rubeis S, He X, Goldberg AP, Poultney CS, Samocha K, Ercument Cicek A, Kou Y, Liu L, Fromer M, Walker S, Singh T, Klei L, Kosmicki J, Fu SC, Aleksic B, Biscaldi M, Bolton PF, Brownfeld JM, Cai J, Campbell NG, Carracedo A, Chahrour MH, Chiocchetti AG, Coon H, Crawford EL, Crooks L, Curran SR, Dawson G, Duketis E, Fernandez BA, Gallagher L, Geller E, Guter SJ, Sean Hill R, Ionita-Laza I, Jimenez Gonzalez P, Kilpinen H, Klauck SM, Kolevzon A, Lee I, Lei J, Lehtimaki T, Lin CF, Ma'ayan A, Marshall CR, McInnes AL, Neale B, Owen MJ, Ozaki N, Parellada M, Parr JR, Purcell S, Puura K, Rajagopalan D, Rehnstrom K, Reichenberg A, Sabo A, Sachse M, Sanders SJ, Schafer C, Schulte-Ruther M, Skuse D, Stevens C, Szatmari P, Tammimies K, Valladares O, Voran A, Wang LS, Weiss LA, Jeremy Willsey A, Yu TW, Yuen RK, Study DDD, Homozygosity Mapping Collaborative for A, Consortium UK, Autism Sequencing C, Cook EH, Freitag CM, Gill M, Hultman CM, Lehner T, Palotie A, Schellenberg GD, Sklar P, State MW, Sutcliffe JS, Walsh CA, Scherer SW, Zwick ME, Barrett JC, Cutler DJ, Roeder K, Devlin B, Daly MJ, Buxbaum JD. Synaptic, transcriptional and chromatin genes disrupted in autism. Nature, 2014; 515: 209-215.
    20. Adachi Y, Kimura H, Sato N, Nagashima W, Nakamura K, Aleksic B, Yoshida K, Fujimoto Y, Nakashima T, Ozaki N. Preoperative Level of Depression is a Predictor of Postoperative Levels of Depression in Patients with Head and Neck Cancer. Jpn J Clin Oncol, 2014; 44: 311-317.
  • 2013年
    1. Watanabe Y, Iijima Y, Egawa J, Nunokawa A, Kaneko N, Arinami T, Ujike H, Inada T, Iwata N, Kunugi H, Itokawa M, Sasaki T, Ozaki N, Hashimoto R, Shibuya M, Igeta H, Someya T. Replication in a Japanese population that a MIR30E gene variation is associated with schizophrenia. Schizophr Res, 2013; 150: 596-597.
    2. Usami M, Okada T, Sasayama D, Iwadare Y, Watanabe K, Ushijima H, Kodaira M, Sugiyama N, Sawa T, Saito K. What time periods of the day are concerning for parents of children with attention deficit hyperactivity disorder? PLoS One, 2013; 8: e79806.
    3. Ukai K, Okajima A, Yamauchi A, Sasaki E, Yamaguchi Y, Kimura H, Aleksic B, Ozaki N. Total palliative care for a patient with multiple cerebral infarctions that occurred repeatedly in association with gastric cancer (Trousseau's syndrome). Palliat Support Care, 2013; 11: 169-172.
    4. Ukai K, Kimura H, Arao M, Aleksic B, Yamauchi A, Ishihara R, Iritani S, Kurita K, Ozaki N. Effectiveness of low-dose milnacipran for a patient suffering from pain disorder with delusional disorder (somatic type) in the orofacial region. Psychogeriatrics, 2013; 13: 99-102.
    5. Tanaka S, Syu A, Ishiguro H, Inada T, Horiuchi Y, Ishikawa M, Koga M, Noguchi E, Ozaki N, Someya T, Kakita A, Takahashi H, Nawa H, Arinami T. DPP6 as a candidate gene for neuroleptic-induced tardive dyskinesia. Pharmacogenomics J, 2013; 13: 27-34.
    6. Takata A, Iwayama Y, Fukuo Y, Ikeda M, Okochi T, Maekawa M, Toyota T, Yamada K, Hattori E, Ohnishi T, Toyoshima M, Ujike H, Inada T, Kunugi H, Ozaki N, Nanko S, Nakamura K, Mori N, Kanba S, Iwata N, Kato T, Yoshikawa T. A Population-Specific Uncommon Variant in GRIN3A Associated with Schizophrenia. Biol Psychiatry, 2013; 73: 532-539.
    7. Shiino T, Koide T, Kushima I, Ikeda M, Kunimoto S, Nakamura Y, Yoshimi A, Aleksic B, Banno M, Kikuchi T, Kohmura K, Adachi Y, Kawano N, Okada T, Inada T, Ujike H, Iidaka T, Suzuki M, Iwata N, Ozaki N. Common variants in bcl9 gene and schizophrenia in a japanese population: Association study, meta-analysis and cognitive function analysis. J Med Biochem, 2013; 32: 351-357.
    8. Shibata H, Yamamoto K, Sun Z, Oka A, Inoko H, Arinami T, Inada T, Ujike H, Itokawa M, Tochigi M, Watanabe Y, Someya T, Kunugi H, Suzuki T, Iwata N, Ozaki N, Fukumaki Y. Genome-wide association study of schizophrenia using microsatellite markers in the Japanese population. Psychiatr Genet, 2013; 23: 117-123.
    9. Seo S, Takayama K, Uno K, Ohi K, Hashimoto R, Nishizawa D, Ikeda K, Ozaki N, Nabeshima T, Miyamoto Y, Nitta A. Functional Analysis of Deep Intronic SNP rs13438494 in Intron 24 of PCLO Gene. PLoS One, 2013; 8: e76960.
    10. Sasada K, Iwamoto K, Kawano N, Kohmura K, Yamamoto M, Aleksic B, Ebe K, Noda Y, Ozaki N. Effects of repeated dosing with mirtazapine, trazodone, or placebo on driving performance and cognitive function in healthy volunteers. Hum Psychopharmacol, 2013; 28: 281-286.
    11. Niwa M, Jaaro-Peled H, Tankou S, Seshadri S, Hikida T, Matsumoto Y, Cascella NG, Kano S, Ozaki N, Nabeshima T, Sawa A. Adolescent stress-induced epigenetic control of dopaminergic neurons via glucocorticoids. Science, 2013; 339: 335-339.
    12. Miyata S, Noda A, Iwamoto K, Kawano N, Okuda M, Ozaki N. Poor sleep quality impairs cognitive performance in older adults. J Sleep Res, 2013; 22: 535-541.
    13. Miura H, Ando Y, Noda Y, Ozak N, Isobe K. Effects of Minocycline on Changes in Brain Tryptophan Metabolism and the Behavior of Juvenile Mice Elicited By Inescapable-Predator Stress. J Trauma Stress Disor Treat 2013; 2.
    14. Manchia M, Adli M, Akula N, Ardau R, Aubry JM, Backlund L, Banzato CE, Baune BT, Bellivier F, Bengesser S, Biernacka JM, Brichant-Petitjean C, Bui E, Calkin CV, Cheng AT, Chillotti C, Cichon S, Clark S, Czerski PM, Dantas C, Zompo MD, Depaulo JR, Detera-Wadleigh SD, Etain B, Falkai P, Frisen L, Frye MA, Fullerton J, Gard S, Garnham J, Goes FS, Grof P, Gruber O, Hashimoto R, Hauser J, Heilbronner U, Hoban R, Hou L, Jamain S, Kahn JP, Kassem L, Kato T, Kelsoe JR, Kittel-Schneider S, Kliwicki S, Kuo PH, Kusumi I, Laje G, Lavebratt C, Leboyer M, Leckband SG, Lopez Jaramillo CA, Maj M, Malafosse A, Martinsson L, Masui T, Mitchell PB, Mondimore F, Monteleone P, Nallet A, Neuner M, Novak T, O'Donovan C, Osby U, Ozaki N, Perlis RH, Pfennig A, Potash JB, Reich-Erkelenz D, Reif A, Reininghaus E, Richardson S, Rouleau GA, Rybakowski JK, Schalling M, Schofield PR, Schubert OK, Schweizer B, Seemuller F, Grigoroiu-Serbanescu M, Severino G, Seymour LR, Slaney C, Smoller JW, Squassina A, Stamm T, Steele J, Stopkova P, Tighe SK, Tortorella A, Turecki G, Wray NR, Wright A, Zandi PP, Zilles D, Bauer M, Rietschel M, McMahon FJ, Schulze TG, Alda M. Assessment of Response to Lithium Maintenance Treatment in Bipolar Disorder: A Consortium on Lithium Genetics (ConLiGen) Report. PLoS One, 2013; 8: e65636.
    15. Kondo K, Ikeda M, Kajio Y, Saito T, Iwayama Y, Aleksic B, Yamada K, Toyota T, Hattori E, Ujike H, Inada T, Kunugi H, Kato T, Yoshikawa T, Ozaki N, Iwata N. Genetic Variants on 3q21 and in the Sp8 Transcription Factor Gene (SP8) as Susceptibility Loci for Psychotic Disorders: A Genetic Association Study. PLoS One, 2013; 8: e70964.
    16. Kohmura K, Iwamoto K, Aleksic B, Sasada K, Kawano N, Katayama H, Noda Y, Noda A, Iidaka T, Ozaki N. Effects of sedative antidepressants on prefrontal cortex activity during verbal fluency task in healthy subjects: a near-infrared spectroscopy study. Psychopharmacology (Berl), 2013; 226: 75-81.
    17. Kawano N, Awata S, Ijuin M, Iwamoto K, Ozaki N. Necessity of normative data on the Japanese version of the Wechsler Memory Scale-Revised Logical Memory subtest for old-old people. Geriatr Gerontol Int, 2013; 13: 726-730.
    18. Kamijima K, Higuchi T, Ishigooka J, Ohmori T, Ozaki N, Kanba S, Kinoshita T, Koyama T, Group AS. Aripiprazole augmentation to antidepressant therapy in Japanese patients with major depressive disorder: A randomized, double-blind, placebo-controlled study (ADMIRE study). J Affect Disord, 2013; 151: 899-905.
    19. Iwamoto K, Kawano N, Sasada K, Kohmura K, Yamamoto M, Ebe K, Noda Y, Ozaki N. Effects of low-dose mirtazapine on driving performance in healthy volunteers. Hum Psychopharmacol, 2013; 28: 523-528.
    20. Ikeda M, Okahisa Y, Aleksic B, Won M, Kondo N, Naruse N, Aoyama-Uehara K, Sora I, Iyo M, Hashimoto R, Kawamura Y, Nishida N, Miyagawa T, Takeda M, Sasaki T, Tokunaga K, Ozaki N, Ujike H, Iwata N. Evidence for shared genetic risk between methamphetamine-induced psychosis and schizophrenia. Neuropsychopharmacology, 2013; 38: 1864-1870.
    21. Ikeda M, Aleksic B, Yamada K, Iwayama-Shigeno Y, Matsuo K, Numata S, Watanabe Y, Ohnuma T, Kaneko T, Fukuo Y, Okochi T, Toyota T, Hattori E, Shimodera S, Itakura M, Nunokawa A, Shibata N, Tanaka H, Yoneda H, Arai H, Someya T, Ohmori T, Yoshikawa T, Ozaki N, Iwata N. Genetic evidence for association between NOTCH4 and schizophrenia supported by a GWAS follow-up study in a Japanese population. Mol Psychiatry, 2013; 18: 636-638.
    22. Hashimoto R, Ikeda M, Ohi K, Yasuda Y, Yamamori H, Fukumoto M, Umeda-Yano S, Dickinson D, Aleksic B, Iwase M, Kazui H, Ozaki N, Weinberger DR, Iwata N, Takeda M. Genome-wide association study of cognitive decline in schizophrenia. Am J Psychiatry, 2013; 170: 683-684.
    23. Furukawa M, Tochigi M, Otowa T, Arinami T, Inada T, Ujike H, Watanabe Y, Iwata N, Itokawa M, Kunugi H, Hashimoto R, Ozaki N, Kakiuchi C, Kasai K, Sasaki T. An association analysis of the cardiomyopathy-associated 5 (CMYA5) gene with schizophrenia in a Japanese population. Psychiatr Genet, 2013; 23: 179-180.
    24. Esaki K, Kondo K, Hatano M, Saito T, Kishi T, Umene-Nakano W, Yoshimura R, Nakamura J, Ozaki N, Ikeda M, Iwata N. Further evidence of an association between a genetic variant in BMP7 and treatment response to SSRIs in major depressive disorder. J Hum Genet, 2013; 58: 568-569.
    25. Balan S, Yamada K, Iwayama Y, Toyota T, Ohnishi T, Maekawa M, Toyoshima M, Iwata Y, Suzuki K, Kikuchi M, Ujike H, Inada T, Kunugi H, Ozaki N, Iwata N, Nanko S, Kato T, Yoshikawa T. Lack of association of EGR2 variants with bipolar disorder in Japanese population. Gene, 2013; 526: 246-250.
    26. Asano M, Esaki K, Wakamatsu A, Kitajima T, Narita T, Naitoh H, Ozaki N, Iwata N. Maternal overprotection score of the Parental Bonding Instrument predicts the outcome of cognitive behavior therapy by trainees for depression. Psychiatry Clin Neurosci, 2013; 67: 340-344.
    27. Aleksic B, Kushima I, Ohye T, Ikeda M, Kunimoto S, Nakamura Y, Yoshimi A, Koide T, Iritani S, Kurahashi H, Iwata N, Ozaki N. Definition and refinement of the 7q36.3 duplication region associated with schizophrenia. Sci Rep, 2013; 3: 2587.
    28. Aleksic B, Kushima I, Hashimoto R, Ohi K, Ikeda M, Yoshimi A, Nakamura Y, Ito Y, Okochi T, Fukuo Y, Yasuda Y, Fukumoto M, Yamamori H, Ujike H, Suzuki M, Inada T, Takeda M, Kaibuchi K, Iwata N, Ozaki N. Analysis of the VAV3 as Candidate Gene for Schizophrenia: Evidences From Voxel-Based Morphometry and Mutation Screening. Schizophr Bull, 2013; 39: 720-728.
  • 2012年
    1. Watanabe Y, Egawa J, Iijima Y, Nunokawa A, Kaneko N, Shibuya M, Arinami T, Ujike H, Inada T, Iwata N, Tochigi M, Kunugi H, Itokawa M, Ozaki N, Hashimoto R, Someya T. A two-stage case-control association study between the tryptophan hydroxylase 2 (TPH2) gene and schizophrenia in a Japanese population. Schizophr Res, 2012; 137: 264-266.
    2. Uno Y, Uchiyama T, Kurosawa M, Aleksic B, Ozaki N. The combined measles, mumps, and rubella vaccines and the total number of vaccines are not associated with development of autism spectrum disorder: The first case-control study in Asia. Vaccine, 2012; 30: 4292-4298.
    3. Torii Y, Iritani S, Sekiguchi H, Habuchi C, Hagikura M, Arai T, Ikeda K, Akiyama H, Ozaki N. Effects of aging on the morphologies of Heschl's gyrus and the superior temporal gyrus in schizophrenia: A postmortem study. Schizophr Res, 2012; 134: 137-142.
    4. Tokura T, Kimura H, Yoshimi A, Ohashi MS, Masuda M, Senzaki K, Yoshida K, Aleksic B, Noda Y, Yamada K, Ozaki N. Reliability and Validity of the Japanese Version of BEMIB Modified for Patients With Bipolar Disorder: a Self-rating Scale for Medication Adherence. Clinical Neuropsychopharmacology and Therapeutics, 2012; 3: 26-32.
    5. Tamaji A, Iwamoto K, Kawamura Y, Takahashi M, Ebe K, Kawano N, Kunimoto S, Aleksic B, Noda Y, Ozaki N. Differential effects of diazepam, tandospirone, and paroxetine on plasma brain-derived neurotrophic factor level under mental stress. Hum Psychopharmacol, 2012; 27: 329-333.
    6. Suzuki M, Takahashi S, Matsushima E, Tsunoda M, Kurachi M, Okada T, Hayashi T, Ishii Y, Morita K, Maeda H, Katayama S, Otsuka T, Hirayasu Y, Sekine M, Okubo Y, Motoshita M, Ohta K, Uchiyama M, Kojima T. Relationships between exploratory eye movement dysfunction and clinical symptoms in schizophrenia. Psychiatry Clin Neurosci, 2012; 66: 187-194.
    7. Okada T, Sato W, Kubota Y, Toichi M, Murai T. Right hemispheric dominance and interhemispheric cooperation in gaze-triggered reflexive shift of attention. Psychiatry Clin Neurosci, 2012; 66: 97-104.
    8. Ohi K, Hashimoto R, Yasuda Y, Fukumoto M, Yamamori H, Umeda-Yano S, Okada T, Kamino K, Morihara T, Iwase M, Kazui H, Numata S, Ikeda M, Ohnuma T, Iwata N, Ueno S, Ozaki N, Ohmori T, Arai H, Takeda M. Functional genetic variation at the NRGN gene and schizophrenia: Evidence from a gene-based case-control study and gene expression analysis. Am J Med Genet B Neuropsychiatr Genet, 2012; 159B: 405-413.
    9. Nakazaki C, Noda A, Koike Y, Yamada S, Murohara T, Ozaki N. Association of insomnia and short sleep duration with atherosclerosis risk in the elderly. Am J Hypertens, 2012; 25: 1149-1155.
    10. Nagashima W, Kimura H, Ito M, Tokura T, Arao M, Aleksic B, Yoshida K, Kurita K, Ozaki N. Effectiveness of duloxetine for the treatment of chronic nonorganic orofacial pain. Clin Neuropharmacol, 2012; 35: 273-277.
    11. Matsunaga S, Ikeda M, Kishi T, Fukuo Y, Aleksic B, Yoshimura R, Okochi T, Yamanouchi Y, Kinoshita Y, Kawashima K, Umene-Nakano W, Inada T, Kunugi H, Kato T, Yoshikawa T, Ujike H, Nakamura J, Ozaki N, Kitajima T, Iwata N. An evaluation of polymorphisms in casein kinase 1 delta and epsilon genes in major psychiatric disorders. Neurosci Lett, 2012; 529: 66-69.
    12. Kushima I, Nakamura Y, Aleksic B, Ikeda M, Ito Y, Shiino T, Okochi T, Fukuo Y, Ujike H, Suzuki M, Inada T, Hashimoto R, Takeda M, Kaibuchi K, Iwata N, Ozaki N. Resequencing and Association Analysis of the KALRN and EPHB1 Genes And Their Contribution to Schizophrenia Susceptibility. Schizophr Bull, 2012; 38: 552-560.
    13. Koide T, Banno M, Aleksic B, Yamashita S, Kikuchi T, Kohmura K, Adachi Y, Kawano N, Kushima I, Nakamura Y, Okada T, Ikeda M, Ohi K, Yasuda Y, Hashimoto R, Inada T, Ujike H, Iidaka T, Suzuki M, Takeda M, Iwata N, Ozaki N. Common Variants in MAGI2 Gene Are Associated with Increased Risk for Cognitive Impairment in Schizophrenic Patients. PLoS One, 2012; 7: e36836.
    14. Koide T, Aleksic B, Kikuchi T, Banno M, Kohmura K, Adachi Y, Kawano N, Iidaka T, Ozaki N. Evaluation of factors affecting continuous performance test identical pairs version score of schizophrenic patients in a Japanese clinical sample. Schizophr Res Treatment, 2012; 2012: 970131.
    15. Kitazawa M, Ohnuma T, Takebayashi Y, Shibata N, Baba H, Ohi K, Yasuda Y, Nakamura Y, Aleksic B, Yoshimi A, Okochi T, Ikeda M, Naitoh H, Hashimoto R, Iwata N, Ozaki N, Takeda M, Arai H. No associations found between the genes situated at 6p22.1, HIST1H2BJ, PRSS16, and PGBD1 in Japanese patients diagnosed with schizophrenia. Am J Med Genet B Neuropsychiatr Genet, 2012; 159B: 456-464.
    16. Kishi T, Ichinose H, Yoshimura R, Fukuo Y, Kitajima T, Inada T, Kunugi H, Kato T, Yoshikawa T, Ujike H, Musso GM, Umene-Nakano W, Nakamura J, Ozaki N, Iwata N. GTP cyclohydrolase 1 gene haplotypes as predictors of SSRI response in Japanese patients with major depressive disorder. J Affect Disord, 2012; 142: 315-322.
    17. Kishi T, Fukuo Y, Okochi T, Kawashima K, Kitajima T, Inada T, Ozaki N, Musso GM, Kane JM, Correll CU, Iwata N. Serotonin 6 receptor gene and schizophrenia: case-control study and meta-analysis. Hum Psychopharmacol, 2012; 27: 63-69.
    18. Kimura H, Yoshida K, Ito M, Tokura T, Nagashima W, Kurita K, Ozaki N. Plasma levels of milnacipran and its effectiveness for the treatment of chronic pain in the orofacial region. Hum Psychopharmacol, 2012; 27: 322-328.
    19. Kikuchi T, Iwamoto K, Sasada K, Aleksic B, Yoshida K, Ozaki N. Sexual dysfunction and hyperprolactinemia in Japanese schizophrenic patients taking antipsychotics. Prog Neuropsychopharmacol Biol Psychiatry, 2012; 37: 26-32.
    20. Kawano N, Iwamoto K, Ebe K, Suzuki Y, Hasegawa J, Ukai K, Umegaki H, Iidaka T, Ozaki N. Effects of mild cognitive impairment on driving performance in older drivers. J Am Geriatr Soc, 2012; 60: 1379-1381.
    21. Kawano N, Iwamoto K, Ebe K, Aleksic B, Noda A, Umegaki H, Kuzuya M, Iidaka T, Ozaki N. Slower adaptation to driving simulator and simulator sickness in older adults. Aging Clin Exp Res, 2012; 24: 285-289.
    22. Horiuchi Y, Iida S, Koga M, Ishiguro H, Iijima Y, Inada T, Watanabe Y, Someya T, Ujike H, Iwata N, Ozaki N, Kunugi H, Tochigi M, Itokawa M, Arai M, Niizato K, Iritani S, Kakita A, Takahashi H, Nawa H, Arinami T. Association of SNPs linked to increased expression of SLC1A1 with schizophrenia. Am J Med Genet B Neuropsychiatr Genet, 2012; 159B: 30-37.
    23. Hayakawa N, Koide T, Okada T, Murase S, Aleksic B, Furumura K, Shiino T, Nakamura Y, Tamaji A, Ishikawa N, Ohoka H, Usui H, Banno N, Morita T, Goto S, Kanai A, Masuda T, Ozaki N. The postpartum depressive state in relation to perceived rearing: a prospective cohort study. PLoS One, 2012; 7: e50220.
    24. Hagikura M, Iwamoto K, Aleksic B, Ozaki N. What is a rational antidepressant treatment for major depression in patients with Parkinson's disease? Psychiatry Clin Neurosci, 2012; 66: 463.
    25. Furumura K, Koide T, Okada T, Murase S, Aleksic B, Hayakawa N, Shiino T, Nakamura Y, Tamaji A, Ishikawa N, Ohoka H, Usui H, Banno N, Morita T, Goto S, Kanai A, Masuda T, Ozaki N. Prospective Study on the Association between Harm Avoidance and Postpartum Depressive State in a Maternal Cohort of Japanese Women. PLoS One, 2012; 7: e34725.
    26. Banno M, Koide T, Aleksic B, Okada T, Kikuchi T, Kohmura K, Adachi Y, Kawano N, Iidaka T, Ozaki N. Wisconsin Card Sorting Test scores and clinical and sociodemographic correlates in Schizophrenia: multiple logistic regression analysis. BMJ Open, 2012; 2.
    27. Adachi Y, Aleksic B, Nobata R, Suzuki T, Yoshida K, Ono Y, Ozaki N. Combination use of Beck Depression Inventory and two-question case-finding instrument as a screening tool for depression in the workplace. BMJ Open, 2012; 2.
  • 2011年
    1. Yoshimura T, Usui H, Takahashi N, Yoshimi A, Saito S, Aleksic B, Ujike H, Inada T, Yamada M, Uchimura N, Iwata N, Sora I, Iyo M, Ozaki N. Association analysis of the GDNF gene with methamphetamine use disorder in a Japanese population. Prog Neuropsychopharmacol Biol Psychiatry, 2011; 35: 1268-1272.
    2. Yokobayashi E, Ujike H, Kotaka T, Okahisa Y, Takaki M, Kodama M, Inada T, Uchimura N, Yamada M, Iwata N, Iyo M, Sora I, Ozaki N, Kuroda S. Association study of serine racemase gene with methamphetamine psychosis. Curr Neuropharmacol, 2011; 9: 169-175.
    3. Ujike H, Kishimoto M, Okahisa Y, Kodama M, Takaki M, Inada T, Uchimura N, Yamada M, Iwata N, Iyo M, Sora I, Ozaki N. Association Between 5HT1b Receptor Gene and Methamphetamine Dependence. Curr Neuropharmacol, 2011; 9: 163-168.
    4. Tsunoka T, Kishi T, Ikeda M, Kitajima T, Yamanouchi Y, Kinoshita Y, Kawashima K, Okochi T, Okumura T, Inada T, Ujike H, Yamada M, Uchimura N, Sora I, Iyo M, Ozaki N, Iwata N. No Association Between GRM3 and Japanese Methamphetamine-Induced Psychosis. Curr Neuropharmacol, 2011; 9: 160-162.
    5. Tsunoda A, Iritani S, Ozaki N. Presenile dementia diagnosed as posterior cortical atrophy. Psychogeriatrics, 2011; 11: 171-176.
    6. Takata A, Kim SH, Ozaki N, Iwata N, Kunugi H, Inada T, Ujike H, Nakamura K, Mori N, Ahn YM, Joo EJ, Song JY, Kanba S, Yoshikawa T, Kim YS, Kato T. Association of ANK3 with bipolar disorder confirmed in East Asia. Am J Med Genet B Neuropsychiatr Genet, 2011; 156: 312-315.
    7. Takahashi N, Nielsen KS, Aleksic B, Petersen S, Ikeda M, Kushima I, Vacaresse N, Ujike H, Iwata N, Dubreuil V, Mirza N, Sakurai T, Ozaki N, Buxbaum JD, Sap J. Loss of Function Studies in Mice and Genetic Association Link Receptor Protein Tyrosine Phosphatase alpha to Schizophrenia. Biol Psychiatry, 2011; 70: 626-635.
    8. Sekiguchi H, Iritani S, Habuchi C, Torii Y, Kuroda K, Kaibuchi K, Ozaki N. Impairment of the tyrosine hydroxylase neuronal network in the orbitofrontal cortex of a genetically modified mouse model of schizophrenia. Brain Res, 2011; 1392: 47-53.
    9. Okumura T, Okochi T, Kishi T, Ikeda M, Kitajima T, Kinoshita Y, Kawashima K, Tsunoka T, Fukuo Y, Inada T, Yamada M, Uchimura N, Iyo M, Sora I, Ozaki N, Ujike H, Iwata N. Genetic Association Analysis of NOS1 and Methamphetamine-Induced Psychosis Among Japanese. Curr Neuropharmacol, 2011; 9: 155-159.
    10. Okochi T, Kishi T, Ikeda M, Kitajima T, Kinoshita Y, Kawashima K, Okumura T, Tsunoka T, Fukuo Y, Inada T, Yamada M, Uchimura N, Iyo M, Sora I, Ozaki N, Ujike H, Iwata N. Genetic Association Analysis of NOS3 and Methamphetamine-Induced Psychosis Among Japanese. Curr Neuropharmacol, 2011; 9: 151-154.
    11. Okahisa Y, Kodama M, Takaki M, Inada T, Uchimura N, Yamada M, Iwata N, Iyo M, Sora I, Ozaki N, Ujike H. Association between the Regulator of G-protein Signaling 9 Gene and Patients with Methamphetamine Use Disorder and Schizophrenia. Curr Neuropharmacol, 2011; 9: 190-194.
    12. Okahisa Y, Kodama M, Takaki M, Inada T, Uchimura N, Yamada M, Iwata N, Iyo M, Sora I, Ozaki N, Ujike H. Association Study of Two Cannabinoid Receptor Genes, CNR1 and CNR2, with Methamphetamine Dependence. Curr Neuropharmacol, 2011; 9: 183-189.
    13. Ogasawara K, Nakamura Y, Aleksic B, Yoshida K, Ando K, Iwata N, Kayukawa Y, Ozaki N. Depression associated with alcohol intake and younger age in Japanese office workers: a case-control and a cohort study. J Affect Disord, 2011; 128: 33-40.
    14. Niwa M, Matsumoto Y, Mouri A, Ozaki N, Nabeshima T. Vulnerability in early life to changes in the rearing environment plays a crucial role in the aetiopathology of psychiatric disorders. Int J Neuropsychopharmacol, 2011; 14: 459-477.
    15. Miura H, Ando Y, Noda Y, Isobe K, Ozaki N. Long-lasting effects of inescapable-predator stress on brain tryptophan metabolism and the behavior of juvenile mice. Stress, 2011; 14: 262-272.
    16. Kubota Y, Takasu NN, Horita S, Kondo M, Shimizu M, Okada T, Wakamura T, Toichi M. Dorsolateral prefrontal cortical oxygenation during REM sleep in humans. Brain Res, 2011; 1389: 83-92.
    17. Kobayashi H, Ujike H, Iwata N, Inada T, Yamada M, Sekine Y, Uchimura N, Iyo M, Ozaki N, Itokawa M, Sora I. Association analysis of the tryptophan hydroxylase 2 gene polymorphisms in patients with methamphetamine dependence/psychosis. Curr Neuropharmacol, 2011; 9: 176-182.
    18. Kobayashi H, Ujike H, Iwata N, Inada T, Yamada M, Sekine Y, Uchimura N, Iyo M, Ozaki N, Itokawa M, Sora I. Association analysis of the adenosine A1 receptor gene polymorphisms in patients with methamphetamine dependence/psychosis. Curr Neuropharmacol, 2011; 9: 137-142.
    19. Kishi T, Yoshimura R, Fukuo Y, Kitajima T, Okochi T, Matsunaga S, Inada T, Kunugi H, Kato T, Yoshikawa T, Ujike H, Umene-Nakano W, Nakamura J, Ozaki N, Serretti A, Correll CU, Iwata N. The CLOCK Gene and Mood Disorders: A Case-Control Study and Meta-analysis. Chronobiol Int, 2011; 28: 825-833.
    20. Kishi T, Okochi T, Tsunoka T, Okumura T, Kitajima T, Kawashima K, Yamanouchi Y, Kinoshita Y, Naitoh H, Inada T, Kunugi H, Kato T, Yoshikawa T, Ujike H, Ozaki N, Iwata N. Serotonin 1A receptor gene, schizophrenia and bipolar disorder: An association study and meta-analysis. Psychiatry Res, 2011; 185: 20-26.
    21. Kishi T, Okochi T, Kitajima T, Ujike H, Inada T, Yamada M, Uchimura N, Sora I, Iyo M, Ozaki N, Correll CU, Iwata N. Lack of association between translin-associated factor X gene (TSNAX) and methamphetamine dependence in the Japanese population. Prog Neuropsychopharmacol Biol Psychiatry, 2011; 35: 1618-1622.
    22. Kishi T, Kitajima T, Tsunoka T, Okumura T, Kawashima K, Okochi T, Yamanouchi Y, Kinoshita Y, Ujike H, Inada T, Yamada M, Uchimura N, Sora I, Iyo M, Ozaki N, Iwata N. Lack of association between prokineticin 2 gene and Japanese methamphetamine dependence. Curr Neuropharmacol, 2011; 9: 133-136.
    23. Kishi T, Kitajima T, Kawashima K, Okochi T, Yamanouchi Y, Kinoshita Y, Ujike H, Inada T, Yamada M, Uchimura N, Sora I, Iyo M, Ozaki N, Iwata N. Association Analysis of Nuclear Receptor Rev-erb Alpha Gene (NR1D1) and Japanese Methamphetamine Dependence. Curr Neuropharmacol, 2011; 9: 129-132.
    24. Kishi T, Fukuo Y, Okochi T, Kitajima T, Ujike H, Inada T, Yamada M, Uchimura N, Sora I, Iyo M, Ozaki N, Correll CU, Iwata N. No significant association between SIRT1 gene and methamphetamine-induced psychosis in the Japanese population. Hum Psychopharmacol, 2011; 26: 445-450.
    25. Kishi T, Fukuo Y, Okochi T, Kitajima T, Kawashima K, Naitoh H, Ujike H, Inada T, Yamada M, Uchimura N, Sora I, Iyo M, Ozaki N, Iwata N. Serotonin 6 receptor gene is associated with methamphetamine-induced psychosis in a Japanese population. Drug Alcohol Depend, 2011; 113: 1-7.
    26. Kishi T, Fukuo Y, Kitajima T, Okochi T, Yamanouchi Y, Kinoshita Y, Kawashima K, Inada T, Kunugi H, Kato T, Yoshikawa T, Ujike H, Ozaki N, Iwata N. SIRT1 gene, schizophrenia and bipolar disorder in the Japanese population: an association study. Genes Brain Behav, 2011; 10: 257-263.
    27. Kikuchi T, Iwamoto K, Sasada K, Aleksic B, Yoshida K, Ozaki N. Reliability and validity of a new sexual function questionnaire (Nagoya Sexual Function Questionnaire) for schizophrenic patients taking antipsychotics. Hum Psychopharmacol, 2011; 26: 300-306.
    28. Ishikawa N, Goto S, Murase S, Kanai A, Masuda T, Aleksic B, Usui H, Ozaki N. Prospective study of maternal depressive symptomatology among Japanese women. J Psychosom Res, 2011; 71: 264-269.
    29. Ikeda M, Aleksic B, Kinoshita Y, Okochi T, Kawashima K, Kushima I, Ito Y, Nakamura Y, Kishi T, Okumura T, Fukuo Y, Williams HJ, Hamshere ML, Ivanov D, Inada T, Suzuki M, Hashimoto R, Ujike H, Takeda M, Craddock N, Kaibuchi K, Owen MJ, Ozaki N, O'Donovan MC, Iwata N. Genome-wide association study of schizophrenia in a Japanese population. Biol Psychiatry, 2011; 69: 472-478.
    30. Iijima Y, Aleksic B, Ozaki N. Necessity for ethical consideration of research in the aftermath of disaster. Psychiatry Clin Neurosci, 2011; 65: 535-536.
    31. Hironaka M, Kotani T, Sumigama S, Tsuda H, Mano Y, Hayakawa H, Tanaka S, Ozaki N, Tamakoshi K, Kikkawa F. Maternal mental disorders and pregnancy outcomes: A clinical study in a Japanese population. J Obstet Gynaecol Res, 2011; 37: 1283-1289.
    32. Hashimoto R, Ohi K, Yasuda Y, Fukumoto M, Yamamori H, Takahashi H, Iwase M, Okochi T, Kazui H, Saitoh O, Tatsumi M, Iwata N, Ozaki N, Kamijima K, Kunugi H, Takeda M. Variants of the RELA gene are associated with schizophrenia and their startle responses. Neuropsychopharmacology, 2011; 36: 1921-1931.
    33. Hashimoto R, Ohi K, Yasuda Y, Fukumoto M, Yamamori H, Kamino K, Morihara T, Iwase M, Kazui H, Numata S, Ikeda M, Ueno S, Ohmori T, Iwata N, Ozaki N, Takeda M. No association between the PCM1 gene and schizophrenia: A multi-center case-control study and a meta-analysis. Schizophr Res, 2011; 129: 80-84.
    34. Habuchi C, Iritani S, Sekiguchi H, Torii Y, Ishihara R, Arai T, Hasegawa M, Tsuchiya K, Akiyama H, Shibayama H, Ozaki N. Clinicopathological study of diffuse neurofibrillary tangles with calcification With special reference to TDP-43 proteinopathy and alpha-synucleinopathy. J Neurol Sci, 2011; 301: 77-85.
    35. Fukuo Y, Kishi T, Kushima I, Yoshimura R, Okochi T, Kitajima T, Matsunaga S, Kawashima K, Umene-Nakano W, Naitoh H, Inada T, Nakamura J, Ozaki N, Iwata N. Possible association between ubiquitin-specific peptidase 46 gene and major depressive disorders in the Japanese population. J Affect Disord, 2011; 133: 150-157.
    36. Fuchikami M, Morinobu S, Segawa M, Okamoto Y, Yamawaki S, Ozaki N, Inoue T, Kusumi I, Koyama T, Tsuchiyama K, Terao T. DNA methylation profiles of the brain-derived neurotrophic factor (BDNF) gene as a potent diagnostic biomarker in major depression. PLoS One, 2011; 6: e23881.
    37. Deng X, Takaki H, Wang L, Kuroki T, Nakahara T, Hashimoto K, Ninomiya H, Arinami T, Inada T, Ujike H, Itokawa M, Tochigi M, Watanabe Y, Someya T, Kunugi H, Iwata N, Ozaki N, Shibata H, Fukumaki Y. Positive association of Phencyclidine-responsive genes, PDE4A and PLAT, with schizophrenia. Am J Med Genet B Neuropsychiatr Genet, 2011; 156: 850-858.
    38. Banno M, Koide T, Aleksic B, Yamada K, Kikuchi T, Kohmura K, Adachi Y, Kawano N, Kushima I, Ikeda M, Inada T, Yoshikawa T, Iwata N, Ozaki N. A case control association study and cognitive function analysis of neuropilin and tolloid-like 1 gene and schizophrenia in the Japanese population. PLoS One, 2011; 6: e28929.
  • 2010年
    1. Yoshimi A, Aleksic B, Kawamura Y, Takahashi N, Yamada S, Usui H, Saito S, Ito Y, Iwata N, Inada T, Noda Y, Yamada K, Ozaki N. Gene-wide association study between the methylenetetrahydrofolate reductase gene (MTHFR) and schizophrenia in the Japanese population, with an updated meta-analysis on currently available data. Schizophr Res, 2010; 124: 216-222.
    2. Yazaki S, Koga M, Ishiguro H, Inada T, Ujike H, Itokawa M, Otowa T, Watanabe Y, Someya T, Iwata N, Kunugi H, Ozaki N, Arinami T. An association study between the dymeclin gene and schizophrenia in the Japanese population. J Hum Genet, 2010; 55: 631-634.
    3. Ukai K, Matsuo K, Nakamura R, Sobue G, Kosaka K, Shibayama H, Iritani S, Ishihara R, Ozaki N. A case of dementia with Lewy bodies that temporarily showed symptoms similar to Creutzfeldt-Jakob disease. Psychogeriatrics, 2010; 10: 201-205.
    4. Tsunoka T, Kishi T, Kitajima T, Okochi T, Okumura T, Yamanouchi Y, Kinoshita Y, Kawashima K, Naitoh H, Inada T, Ujike H, Yamada M, Uchimura N, Sora I, Iyo M, Ozaki N, Iwata N. Association analysis of GRM2 and HTR2A with methamphetamine-induced psychosis and schizophrenia in the Japanese population. Prog Neuropsychopharmacol Biol Psychiatry, 2010; 34: 639-644.
    5. Tomida K, Takahashi N, Saito S, Maeno N, Iwamoto K, Yoshida K, Kimura H, Iidaka T, Ozaki N. Relationship of psychopathological symptoms and cognitive function to subjective quality of life in patients with chronic schizophrenia. Psychiatry Clin Neurosci, 2010; 64: 62-69.
    6. Takahashi M, Iwamoto K, Kawamura Y, Nakamura Y, Ishihara R, Uchiyama Y, Ebe K, Noda A, Noda Y, Yoshida K, Iidaka T, Ozaki N. The effects of acute treatment with tandospirone, diazepam, and placebo on driving performance and cognitive function in healthy volunteers. Hum Psychopharmacol, 2010; 25: 260-267.
    7. Takahashi M, Iwamoto K, Fukatsu H, Naganawa S, Iidaka T, Ozaki N. White matter microstructure of the cingulum and cerebellar peduncle is related to sustained attention and working memory: a diffusion tensor imaging study. Neurosci Lett, 2010; 477: 72-76.
    8. Takahashi M, Hayashi H, Watanabe Y, Sawamura K, Fukui N, Watanabe J, Kitajima T, Yamanouchi Y, Iwata N, Mizukami K, Hori T, Shimoda K, Ujike H, Ozaki N, Iijima K, Takemura K, Aoshima H, Someya T. Diagnostic classification of schizophrenia by neural network analysis of blood-based gene expression signatures. Schizophr Res, 2010; 119: 210-218.
    9. Syu A, Ishiguro H, Inada T, Horiuchi Y, Tanaka S, Ishikawa M, Arai M, Itokawa M, Niizato K, Iritani S, Ozaki N, Takahashi M, Kakita A, Takahashi H, Nawa H, Keino-Masu K, Arikawa-Hirasawa E, Arinami T. Association of the HSPG2 gene with neuroleptic-induced tardive Dyskinesia. Neuropsychopharmacology, 2010; 35: 1155-1164.
    10. Schulze TG, Alda M, Adli M, Akula N, Ardau R, Bui ET, Chillotti C, Cichon S, Czerski P, Del Zompo M, Detera-Wadleigh SD, Grof P, Gruber O, Hashimoto R, Hauser J, Hoban R, Iwata N, Kassem L, Kato T, Kittel-Schneider S, Kliwicki S, Kelsoe JR, Kusumi I, Laje G, Leckband SG, Manchia M, Macqueen G, Masui T, Ozaki N, Perlis RH, Pfennig A, Piccardi P, Richardson S, Rouleau G, Reif A, Rybakowski JK, Sasse J, Schumacher J, Severino G, Smoller JW, Squassina A, Turecki G, Young LT, Yoshikawa T, Bauer M, McMahon FJ. The International Consortium on Lithium Genetics (ConLiGen): An Initiative by the NIMH and IGSLI to Study the Genetic Basis of Response to Lithium Treatment. Neuropsychobiology, 2010; 62: 72-78.
    11. Okuda A, Suzuki T, Kishi T, Yamanouchi Y, Umeda K, Haitoh H, Hashimoto S, Ozaki N, Iwata N. Duration of untreated illness and antidepressant fluvoxamine response in major depressive disorder. Psychiatry Clin Neurosci, 2010; 64: 268-273.
    12. Okuda A, Kishi T, Okochi T, Ikeda M, Kitajima T, Tsunoka T, Okumukura T, Fukuo Y, Kinoshita Y, Kawashima K, Yamanouchi Y, Inada T, Ozaki N, Iwata N. Translin-associated factor X gene (TSNAX) may be associated with female major depressive disorder in the Japanese population. Neuromolecular Med, 2010; 12: 78-85.
    13. Ohnuma T, Shibata N, Baba H, Ohi K, Yasuda Y, Nakamura Y, Okochi T, Naitoh H, Hashimoto R, Iwata N, Ozaki N, Takeda M, Arai H. No association between DAO and schizophrenia in a Japanese patient population: a multicenter replication study. Schizophr Res, 2010; 118: 300-302.
    14. Ohi K, Hashimoto R, Yasuda Y, Yoshida T, Takahashi H, Iike N, Iwase M, Kamino K, Ishii R, Kazui H, Fukumoto M, Takamura H, Yamamori H, Azechi M, Ikezawa K, Tanimukai H, Tagami S, Morihara T, Okochi M, Yamada K, Numata S, Ikeda M, Tanaka T, Kudo T, Ueno S, Yoshikawa T, Ohmori T, Iwata N, Ozaki N, Takeda M. The chitinase 3-like 1 gene and schizophrenia: evidence from a multi-center case-control study and meta-analysis. Schizophr Res, 2010; 116: 126-132.
    15. Nunokawa A, Watanabe Y, Kaneko N, Sugai T, Yazaki S, Arinami T, Ujike H, Inada T, Iwata N, Kunugi H, Sasaki T, Itokawa M, Ozaki N, Hashimoto R, Someya T. The dopamine D3 receptor (DRD3) gene and risk of schizophrenia: case-control studies and an updated meta-analysis. Schizophr Res, 2010; 116: 61-67.
    16. Noda Y, Mouri A, Ando Y, Waki Y, Yamada SN, Yoshimi A, Yamada K, Ozaki N, Wang D, Nabeshima T. Galantamine ameliorates the impairment of recognition memory in mice repeatedly treated with methamphetamine: involvement of allosteric potentiation of nicotinic acetylcholine receptors and dopaminergic-ERK1/2 systems. Int J Neuropsychopharmacol, 2010; 13: 1343-1354.
    17. Nishiyama T, Ozaki N. Measurement limit of quality-of-life questionnaires in psychiatric settings. Qual Life Res, 2010; 19: 25-30.
    18. Nakamura Y, Ito Y, Aleksic B, Kushima I, Yasui-Furukori N, Inada T, Ono Y, Ozaki N. Influence of HTR2A polymorphisms and parental rearing on personality traits in healthy Japanese subjects. J Hum Genet, 2010; 55: 838-841.
    19. Morikawa T, Manabe T, Ito Y, Yamada S, Yoshimi A, Nagai T, Ozaki N, Mayeda A. The expression of HMGA1a is increased in lymphoblastoid cell lines from schizophrenia patients. Neurochem Int, 2010; 56: 736-739.
    20. Miyata S, Noda A, Ozaki N, Hara Y, Minoshima M, Iwamoto K, Takahashi M, Iidaka T, Koike Y. Insufficient sleep impairs driving performance and cognitive function. Neurosci Lett, 2010; 469: 229-233.
    21. Kushima I, Aleksic B, Ito Y, Nakamura Y, Nakamura K, Mori N, Kikuchi M, Inada T, Kunugi H, Nanko S, Kato T, Yoshikawa T, Ujike H, Suzuki M, Iwata N, Ozaki N. Association study of ubiquitin-specific peptidase 46 (USP46) with bipolar disorder and schizophrenia in a Japanese population. J Hum Genet, 2010; 55: 133-136.
    22. Kushima I, Aleksic B, Ikeda M, Yamanouchi Y, Kinoshita Y, Ito Y, Nakamura Y, Inada T, Iwata N, Ozaki N. Association study of bromodomain-containing 1 gene with schizophrenia in Japanese population. Am J Med Genet B Neuropsychiatr Genet, 2010; 153B: 786-791.
    23. Koide T, Aleksic B, Ito Y, Usui H, Yoshimi A, Inada T, Suzuki M, Hashimoto R, Takeda M, Iwata N, Ozaki N. A two-stage case-control association study of the dihydropyrimidinase-like 2 gene (DPYSL2) with schizophrenia in Japanese subjects. J Hum Genet, 2010; 55: 469-472.
    24. Kobayashi H, Ujike H, Iwata N, Inada T, Yamada M, Sekine Y, Uchimura N, Iyo M, Ozaki N, Itokawa M, Sora I. The adenosine A2A receptor is associated with methamphetamine dependence/psychosis in the Japanese population. Behav Brain Funct, 2010; 6: 50.
    25. Kishi T, Yoshimura R, Okochi T, Fukuo Y, Kitajima T, Okumura T, Tsunoka T, Kawashima K, Yamanouchi Y, Kinoshita Y, Umene-Nakano W, Naitoh H, Nakamura J, Ozaki N, Iwata N. Association analysis of SIGMAR1 with major depressive disorder and SSRI response. Neuropharmacology, 2010; 58: 1168-1173.
    26. Kishi T, Yoshimura R, Kitajima T, Okochi T, Okumura T, Tsunoka T, Yamanouchi Y, Kinoshita Y, Kawashima K, Naitoh H, Nakamura J, Ozaki N, Iwata N. HTR2A is associated with SSRI response in Major Depressive Disorder in a Japanese cohort. Neuromolecular Med, 2010; 12: 237-242.
    27. Kishi T, Yoshimura R, Kitajima T, Okochi T, Okumura T, Tsunoka T, Yamanouchi Y, Kinoshita Y, Kawashima K, Fukuo Y, Naitoh H, Umene-Nakano W, Inada T, Nakamura J, Ozaki N, Iwata N. SIRT1 gene is associated with major depressive disorder in the Japanese population. J Affect Disord, 2010; 126: 167-173.
    28. Kishi T, Tsunoka T, Ikeda M, Kitajima T, Kawashima K, Okochi T, Okumura T, Yamanouchi Y, Kinoshita Y, Ujike H, Inada T, Yamada M, Uchimura N, Sora I, Iyo M, Ozaki N, Iwata N. Serotonin 1A receptor gene is associated with Japanese methamphetamine-induced psychosis patients. Neuropharmacology, 2010; 58: 452-456.
    29. Kishi T, Kitajima T, Tsunoka T, Okumura T, Okochi T, Kawashima K, Inada T, Ujike H, Yamada M, Uchimura N, Sora I, Iyo M, Ozaki N, Iwata N. PROKR2 is associated with methamphetamine dependence in the Japanese population. Prog Neuropsychopharmacol Biol Psychiatry, 2010; 34: 1033-1036.
    30. Kishi T, Fukuo Y, Yoshimura R, Okochi T, Kitajima T, Naitoh H, Umene-Nakano W, Nakamura J, Ozaki N, Iwata N. Pharmacogenetic study of serotonin 6 receptor gene with antidepressant response in major depressive disorder in the Japanese population. Hum Psychopharmacol, 2010; 25: 481-486.
    31. Iwayama Y, Hattori E, Maekawa M, Yamada K, Toyota T, Ohnishi T, Iwata Y, Tsuchiya KJ, Sugihara G, Kikuchi M, Hashimoto K, Iyo M, Inada T, Kunugi H, Ozaki N, Iwata N, Nanko S, Iwamoto K, Okazaki Y, Kato T, Yoshikawa T. Association analyses between brain-expressed fatty-acid binding protein (FABP) genes and schizophrenia and bipolar disorder. Am J Med Genet B Neuropsychiatr Genet, 2010; 153B: 484-493.
    32. Ito M, Kimura H, Yoshida K, Kimura Y, Ozaki N, Kurita K. Effectiveness of milnacipran for the treatment of chronic pain in the orofacial region. Clin Neuropharmacol, 2010; 33: 79-83.
    33. Ishiguro H, Koga M, Horiuchi Y, Noguchi E, Morikawa M, Suzuki Y, Arai M, Niizato K, Iritani S, Itokawa M, Inada T, Iwata N, Ozaki N, Ujike H, Kunugi H, Sasaki T, Takahashi M, Watanabe Y, Someya T, Kakita A, Takahashi H, Nawa H, Arinami T. Supportive evidence for reduced expression of GNB1L in schizophrenia. Schizophr Bull, 2010; 36: 756-765.
    34. Ishiguro H, Horiuchi Y, Ishikawa M, Koga M, Imai K, Suzuki Y, Morikawa M, Inada T, Watanabe Y, Takahashi M, Someya T, Ujike H, Iwata N, Ozaki N, Onaivi ES, Kunugi H, Sasaki T, Itokawa M, Arai M, Niizato K, Iritani S, Naka I, Ohashi J, Kakita A, Takahashi H, Nawa H, Arinami T. Brain cannabinoid CB2 receptor in schizophrenia. Biol Psychiatry, 2010; 67: 974-982.
    35. Iritani S, Sekiguchi H, Habuchi C, Torii Y, Yamada S, Waki Y, Noda Y, Furukawa H, Nabeshima T, Ozaki N. Immunohistochemical study of vesicle monoamine transporter 2 in the hippocampal formation of PCP-treated mice. Neurosci Res, 2010; 68: 125-130.
    36. Iritani S, Sekiguchi H, Habuchi C, Hikita T, Taya S, Kaibuchi K, Ozaki N. Immunohistochemical study of vesicle monoamine transporter 2 in the hippocampal region of genetic animal model of schizophrenia. Synapse, 2010; 64: 948-953.
    37. Ikeda M, Tomita Y, Mouri A, Koga M, Okochi T, Yoshimura R, Yamanouchi Y, Kinoshita Y, Hashimoto R, Williams HJ, Takeda M, Nakamura J, Nabeshima T, Owen MJ, O'Donovan MC, Honda H, Arinami T, Ozaki N, Iwata N. Identification of novel candidate genes for treatment response to risperidone and susceptibility for schizophrenia: integrated analysis among pharmacogenomics, mouse expression, and genetic case-control association approaches. Biol Psychiatry, 2010; 67: 263-269.
    38. Ikeda M, Aleksic B, Kirov G, Kinoshita Y, Yamanouchi Y, Kitajima T, Kawashima K, Okochi T, Kishi T, Zaharieva I, Owen MJ, O'Donovan MC, Ozaki N, Iwata N. Copy number variation in schizophrenia in the Japanese population. Biol Psychiatry, 2010; 67: 283-286.
    39. Iidaka T, Saito DN, Komeda H, Mano Y, Kanayama N, Osumi T, Ozaki N, Sadato N. Transient neural activation in human amygdala involved in aversive conditioning of face and voice. J Cogn Neurosci, 2010; 22: 2074-2085.
    40. Hashimoto R, Noguchi H, Hori H, Nakabayashi T, Suzuki T, Iwata N, Ozaki N, Kosuga A, Tatsumi M, Kamijima K, Harada S, Takeda M, Saitoh O, Kunugi H. A genetic variation in the dysbindin gene (DTNBP1) is associated with memory performance in healthy controls. World J Biol Psychiatry, 2010; 11: 431-438.
    41. Hashimoto R, Hashimoto H, Shintani N, Ohi K, Hori H, Saitoh O, Kosuga A, Tatsumi M, Iwata N, Ozaki N, Kamijima K, Baba A, Takeda M, Kunugi H. Possible association between the pituitary adenylate cyclase-activating polypeptide (PACAP) gene and major depressive disorder. Neurosci Lett, 2010; 468: 300-302.
    42. Fukuo Y, Kishi T, Yoshimura R, Kitajima T, Okochi T, Yamanouchi Y, Kinoshita Y, Kawashima K, Naitoh H, Umene-Nakano W, Inada T, Kunugi H, Kato T, Yoshikawa T, Ujike H, Nakamura J, Ozaki N, Iwata N. Serotonin 6 receptor gene and mood disorders: case-control study and meta-analysis. Neurosci Res, 2010; 67: 250-255.
    43. Fukuo Y, Kishi T, Okochi T, Kitajima T, Tsunoka T, Okumukura T, Kinoshita Y, Kawashima K, Yamanouchi Y, Umene-Nakano W, Naitoh H, Inada T, Yoshimura R, Nakamura J, Ozaki N, Iwata N. Lack of Association Between MAGEL2 and Schizophrenia and Mood Disorders in the Japanese Population. Neuromolecular Med, 2010; 12: 285-291.
    44. Amagane H, Watanabe Y, Kaneko N, Nunokawa A, Muratake T, Ishiguro H, Arinami T, Ujike H, Inada T, Iwata N, Kunugi H, Sasaki T, Hashimoto R, Itokawa M, Ozaki N, Someya T. Failure to find an association between myosin heavy chain 9, non-muscle (MYH9) and schizophrenia: a three-stage case-control association study. Schizophr Res, 2010; 118: 106-112.
    45. Aleksic B, Kushima I, Ito Y, Nakamura Y, Ujike H, Suzuki M, Inada T, Hashimoto R, Takeda M, Iwata N, Ozaki N. Genetic association study of KREMEN1 and DKK1 and schizophrenia in a Japanese population. Schizophr Res, 2010; 118: 113-117.
    46. Adachi Y, Aleksic B, Ozaki N. Comparison of pharmacological profiles of serotonin norepinephrine reuptake inhibitors. Clinical Neuropsychopharmacology and Therapeutics, 2010; 1: 10-15.
  • 2009年
    1. Watanabe Y, Nunokawa A, Kaneko N, Muratake T, Arinami T, Ujike H, Inada T, Iwata N, Kunugi H, Itokawa M, Otowa T, Ozaki N, Someya T. Two-stage case-control association study of polymorphisms in rheumatoid arthritis susceptibility genes with schizophrenia. J Hum Genet, 2009; 54: 62-65.
    2. Watanabe Y, Nunokawa A, Kaneko N, Arinami T, Ujike H, Inada T, Iwata N, Kunugi H, Itokawa M, Otowa T, Ozaki N, Someya T. A two-stage case-control association study of PADI2 with schizophrenia. J Hum Genet, 2009; 54: 430-432.
    3. Ukai K, Shibayama H, Ishihara R, Ozaki N. Distribution of neurofibrillary tangles in diffuse neurofibrillary tangles with calcification. Psychiatry Clin Neurosci, 2009; 63: 646-651.
    4. Ujike H, Katsu T, Okahisa Y, Takaki M, Kodama M, Inada T, Uchimura N, Yamada M, Iwata N, Sora I, Iyo M, Ozaki N, Kuroda S. Genetic variants of D2 but not D3 or D4 dopamine receptor gene are associated with rapid onset and poor prognosis of methamphetamine psychosis. Prog Neuropsychopharmacol Biol Psychiatry, 2009; 33: 625-629.
    5. Ueno H, Nishigaki Y, Kong QP, Fuku N, Kojima S, Iwata N, Ozaki N, Tanaka M. Analysis of mitochondrial DNA variants in Japanese patients with schizophrenia. Mitochondrion, 2009; 9: 385-393.
    6. Tsunoka T, Kishi T, Ikeda M, Kitajima T, Yamanouchi Y, Kinoshita Y, Kawashima K, Okochi T, Okumura T, Inada T, Ozaki N, Iwata N. Association analysis of Group II metabotropic glutamate receptor genes (GRM2 and GRM3) with mood disorders and fluvoxamine response in a Japanese population. Prog Neuropsychopharmacol Biol Psychiatry, 2009; 33: 875-879.
    7. Takahashi T, Suzuki M, Tsunoda M, Maeno N, Kawasaki Y, Zhou SY, Hagino H, Niu L, Tsuneki H, Kobayashi S, Sasaoka T, Seto H, Kurachi M, Ozaki N. The Disrupted-in-Schizophrenia-1 Ser704Cys polymorphism and brain morphology in schizophrenia. Psychiatry Res, 2009; 172: 128-135.
    8. Suzuki M, Takahashi S, Matsushima E, Tsunoda M, Kurachi M, Okada T, Hayashi T, Ishii Y, Morita K, Maeda H, Katayama S, Kawahara R, Otsuka T, Hirayasu Y, Sekine M, Okubo Y, Motoshita M, Ohta K, Uchiyama M, Kojima T. Exploratory eye movement dysfunction as a discriminator for schizophrenia : a large sample study using a newly developed digital computerized system. Eur Arch Psychiatry Clin Neurosci, 2009; 259: 186-194.
    9. Shibata H, Tani A, Chikuhara T, Kikuta R, Sakai M, Ninomiya H, Tashiro N, Iwata N, Ozaki N, Fukumaki Y. Association study of polymorphisms in the group III metabotropic glutamate receptor genes, GRM4 and GRM7, with schizophrenia. Psychiatry Res, 2009; 167: 88-96.
    10. Okumura T, Okochi T, Kishi T, Ikeda M, Kitajima T, Yamanouchi Y, Kinoshita Y, Kawashima K, Tsunoka T, Ujike H, Inada T, Ozaki N, Iwata N. No association between polymorphisms of neuronal oxide synthase 1 gene (NOS1) and schizophrenia in a Japanese population. Neuromolecular Med, 2009; 11: 123-127.
    11. Okumura T, Kishi T, Okochi T, Ikeda M, Kitajima T, Yamanouchi Y, Kinoshita Y, Kawashima K, Tsunoka T, Inada T, Ozaki N, Iwata N. Genetic Association Analysis of Functional Polymorphisms in Neuronal Nitric Oxide Synthase 1 Gene (NOS1) and Mood Disorders and Fluvoxamine Response in Major Depressive Disorder in the Japanese Population. Neuropsychobiology, 2009; 61: 57-63.
    12. Okochi T, Kishi T, Ikeda M, Kitajima T, Kinoshita Y, Kawashima K, Okumura T, Tsunoka T, Inada T, Yamada M, Uchimura N, Iyo M, Sora I, Ozaki N, Ujike H, Iwata N. Genetic association analysis of NRG1 with methamphetamine-induced psychosis in a Japanese population. Prog Neuropsychopharmacol Biol Psychiatry, 2009; 33: 903-905.
    13. Okochi T, Ikeda M, Kishi T, Kawashima K, Kinoshita Y, Kitajima T, Yamanouchi Y, Tomita M, Inada T, Ozaki N, Iwata N. Meta-analysis of association between genetic variants in COMT and schizophrenia: an update. Schizophr Res, 2009; 110: 140-148.
    14. Okahisa Y, Ujike H, Kotaka T, Morita Y, Kodama M, Inada T, Yamada M, Iwata N, Iyo M, Sora I, Ozaki N, Kuroda S. Association between neuropeptide Y gene and its receptor Y1 gene and methamphetamine dependence. Psychiatry Clin Neurosci, 2009; 63: 417-422.
    15. Ohi K, Hashimoto R, Yasuda Y, Yoshida T, Takahashi H, Iike N, Fukumoto M, Takamura H, Iwase M, Kamino K, Ishii R, Kazui H, Sekiyama R, Kitamura Y, Azechi M, Ikezawa K, Kurimoto R, Kamagata E, Tanimukai H, Tagami S, Morihara T, Ogasawara M, Okochi M, Tokunaga H, Numata S, Ikeda M, Ohnuma T, Ueno S, Fukunaga T, Tanaka T, Kudo T, Arai H, Ohmori T, Iwata N, Ozaki N, Takeda M. Association study of the G72 gene with schizophrenia in a Japanese population: a multicenter study. Schizophr Res, 2009; 109: 80-85.
    16. Ohi K, Hashimoto R, Yasuda Y, Yamamori H, Hori H, Saitoh O, Tatsumi M, Takeda M, Iwata N, Ozaki N, Kamijima K, Kunugi H. No association between the Bcl2-interacting killer (BIK) gene and schizophrenia. Neurosci Lett, 2009; 463: 60-63.
    17. Nishiyama T, Ozaki N, Iwata N. Use of questionnaire infeasibility in order to detect cognitive disorders: example of the Center for Epidemiologic Studies Depression Scale in psychiatry settings. Psychiatry Clin Neurosci, 2009; 63: 23-29.
    18. Nishiyama T, Ozaki N, Iwata N. Practice-based depression screening for psychiatry outpatients: feasibility comparison of two-types of Center for Epidemiologic Studies Depression Scales. Psychiatry Clin Neurosci, 2009; 63: 632-638.
    19. Nakamura K, Sekine Y, Takei N, Iwata Y, Suzuki K, Anitha A, Inada T, Harano M, Komiyama T, Yamada M, Iwata N, Iyo M, Sora I, Ozaki N, Ujike H, Mori N. An association study of monoamine oxidase A (MAOA) gene polymorphism in methamphetamine psychosis. Neurosci Lett, 2009; 455: 120-123.
    20. Miura H, Shirokawa T, Isobe K, Ozaki N. Shifting the balance of brain tryptophan metabolism elicited by isolation housing and systemic administration of lipopolysaccharide in mice. Stress, 2009; 12: 206-214.
    21. Kubota K, Inoue K, Hashimoto R, Kumamoto N, Kosuga A, Tatsumi M, Kamijima K, Kunugi H, Iwata N, Ozaki N, Takeda M, Tohyama M. Tumor necrosis factor receptor-associated protein 1 regulates cell adhesion and synaptic morphology via modulation of N-cadherin expression. J Neurochem, 2009; 110: 496-508.
    22. Kotaka T, Ujike H, Okahisa Y, Takaki M, Nakata K, Kodama M, Inada T, Yamada M, Uchimura N, Iwata N, Sora I, Iyo M, Ozaki N, Kuroda S. G72 gene is associated with susceptibility to methamphetamine psychosis. Prog Neuropsychopharmacol Biol Psychiatry, 2009; 33: 1046-1049.
    23. Koga M, Ishiguro H, Yazaki S, Horiuchi Y, Arai M, Niizato K, Iritani S, Itokawa M, Inada T, Iwata N, Ozaki N, Ujike H, Kunugi H, Sasaki T, Takahashi M, Watanabe Y, Someya T, Kakita A, Takahashi H, Nawa H, Muchardt C, Yaniv M, Arinami T. Involvement of SMARCA2/BRM in the SWI/SNF chromatin-remodeling complex in schizophrenia. Hum Mol Genet, 2009; 18: 2483-2494.
    24. Kishi T, Tsunoka T, Ikeda M, Kawashima K, Okochi T, Kitajima T, Kinoshita Y, Okumura T, Yamanouchi Y, Inada T, Ozaki N, Iwata N. Serotonin 1A receptor gene and major depressive disorder: an association study and meta-analysis. J Hum Genet, 2009; 54: 629-633.
    25. Kishi T, Kitajima T, Tsunoka T, Okumura T, Ikeda M, Okochi T, Kinoshita Y, Kawashima K, Yamanouchi Y, Ozaki N, Iwata N. Possible association of prokineticin 2 receptor gene (PROKR2) with mood disorders in the Japanese population. Neuromolecular Med, 2009; 11: 114-122.
    26. Kishi T, Kitajima T, Tsunoka T, Ikeda M, Yamanouchi Y, Kinoshita Y, Kawashima K, Okochi T, Okumura T, Inada T, Ozaki N, Iwata N. Genetic association analysis of serotonin 2A receptor gene (HTR2A) with bipolar disorder and major depressive disorder in the Japanese population. Neurosci Res, 2009; 64: 231-234.
    27. Kishi T, Kitajima T, Ikeda M, Yamanouchi Y, Kinoshita Y, Kawashima K, Okochi T, Ozaki N, Iwata N. Orphan Nuclear Receptor Rev-erb Alpha Gene (NR1D1) and Fluvoxamine Response in Major Depressive Disorder in the Japanese Population. Neuropsychobiology, 2009; 59: 234-238.
    28. Kishi T, Kitajima T, Ikeda M, Yamanouchi Y, Kinoshita Y, Kawashima K, Okochi T, Okumura T, Tsunoka T, Ozaki N, Iwata N. CLOCK may predict the response to fluvoxamine treatment in Japanese major depressive disorder patients. Neuromolecular Med, 2009; 11: 53-57.
    29. Kishi T, Kitajima T, Ikeda M, Yamanouchi Y, Kinoshita Y, Kawashima K, Okochi T, Okumura T, Tsunoka T, Inada T, Ozaki N, Iwata N. Association study of clock gene (CLOCK) and schizophrenia and mood disorders in the Japanese population. Eur Arch Psychiatry Clin Neurosci, 2009; 259: 293-297.
    30. Kishi T, Ikeda M, Kitajima T, Yamanouchi Y, Kinoshita Y, Kawashima K, Okochi T, Tsunoka T, Okumura T, Inada T, Ujike H, Yamada M, Uchimura N, Sora I, Iyo M, Ozaki N, Iwata N. A functional polymorphism in estrogen receptor alpha gene is associated with Japanese methamphetamine induced psychosis. Prog Neuropsychopharmacol Biol Psychiatry, 2009; 33: 895-898.
    31. Kishi T, Ikeda M, Kitajima T, Yamanouchi Y, Kinoshita Y, Kawashima K, Okochi T, Okumura T, Tsunoka T, Inada T, Ozaki N, Iwata N. Association analysis of functional polymorphism in estrogen receptor alpha gene with schizophrenia and mood disorders in the Japanese population. Psychiatr Genet, 2009; 19: 217-218.
    32. Kawashima K, Ikeda M, Kishi T, Kitajima T, Yamanouchi Y, Kinoshita Y, Okochi T, Aleksic B, Tomita M, Okada T, Kunugi H, Inada T, Ozaki N, Iwata N. BDNF is not associated with schizophrenia: data from a Japanese population study and meta-analysis. Schizophr Res, 2009; 112: 72-79.
    33. Hattori E, Toyota T, Ishitsuka Y, Iwayama Y, Yamada K, Ujike H, Morita Y, Kodama M, Nakata K, Minabe Y, Nakamura K, Iwata Y, Takei N, Mori N, Naitoh H, Yamanouchi Y, Iwata N, Ozaki N, Kato T, Nishikawa T, Kashiwa A, Suzuki M, Shioe K, Shinohara M, Hirano M, Nanko S, Akahane A, Ueno M, Kaneko N, Watanabe Y, Someya T, Hashimoto K, Iyo M, Itokawa M, Arai M, Nankai M, Inada T, Yoshida S, Kunugi H, Nakamura M, Iijima Y, Okazaki Y, Higuchi T, Yoshikawa T. Preliminary genome-wide association study of bipolar disorder in the Japanese population. Am J Med Genet B Neuropsychiatr Genet, 2009; 150B: 1110-1117.
    34. Hakamata Y, Iwase M, Iwata H, Kobayashi T, Tamaki T, Nishio M, Matsuda H, Ozaki N, Inada T. Gender difference in relationship between anxiety-related personality traits and cerebral brain glucose metabolism. Psychiatry Res, 2009; 173: 206-211.
    35. Arai S, Shibata H, Sakai M, Ninomiya H, Iwata N, Ozaki N, Fukumaki Y. Association analysis of the glutamic acid decarboxylase 2 and the glutamine synthetase genes (GAD2, GLUL) with schizophrenia. Psychiatr Genet, 2009; 19: 6-13.
  • 2008年
    1. Yoshimi A, Takahashi N, Saito S, Ito Y, Aleksic B, Usui H, Kawamura Y, Waki Y, Yoshikawa T, Kato T, Iwata N, Inada T, Noda Y, Ozaki N. Genetic analysis of the gene coding for DARPP-32 (PPP1R1B) in Japanese patients with schizophrenia or bipolar disorder. Schizophr Res, 2008; 100: 334-341.
    2. Yoshida K, Higuchi H, Takahashi H, Kamata M, Sato K, Inoue K, Suzuki T, Itoh K, Ozaki N. Influence of the tyrosine hydroxylase val81met polymorphism and catechol-O-methyltransferase val158met polymorphism on the antidepressant effect of milnacipran. Hum Psychopharmacol, 2008; 23: 121-128.
    3. Yamasaki N, Maekawa M, Kobayashi K, Kajii Y, Maeda J, Soma M, Takao K, Tanda K, Ohira K, Toyama K, Kanzaki K, Fukunaga K, Sudo Y, Ichinose H, Ikeda M, Iwata N, Ozaki N, Suzuki H, Higuchi M, Suhara T, Yuasa S, Miyakawa T. Alpha-CaMKII deficiency causes immature dentate gyrus, a novel candidate endophenotype of psychiatric disorders. Mol Brain, 2008; 1: 6.
    4. Uhl GR, Drgon T, Liu QR, Johnson C, Walther D, Komiyama T, Harano M, Sekine Y, Inada T, Ozaki N, Iyo M, Iwata N, Yamada M, Sora I, Chen CK, Liu HC, Ujike H, Lin SK. Genome-wide association for methamphetamine dependence: convergent results from 2 samples. Arch Gen Psychiatry, 2008; 65: 345-355.
    5. Tanaka M, Kobayashi D, Murakami Y, Ozaki N, Suzuki T, Iwata N, Haraguchi K, Ieiri I, Kinukawa N, Hosoi M, Ohtani H, Sawada Y, Mine K. Genetic polymorphisms in the 5-hydroxytryptamine type 3B receptor gene and paroxetine-induced nausea. Int J Neuropsychopharmacol, 2008; 11: 261-267.
    6. Takahashi T, Suzuki M, Tsunoda M, Kawamura Y, Takahashi N, Tsuneki H, Kawasaki Y, Zhou SY, Kobayashi S, Sasaoka T, Seto H, Kurachi M, Ozaki N. Association between the brain-derived neurotrophic factor Val66Met polymorphism and brain morphology in a Japanese sample of schizophrenia and healthy comparisons. Neurosci Lett, 2008; 435: 34-39.
    7. Takahashi T, Suzuki M, Tsunoda M, Kawamura Y, Takahashi N, Maeno N, Kawasaki Y, Zhou SY, Hagino H, Niu L, Tsuneki H, Kobayashi S, Sasaoka T, Seto H, Kurachi M, Ozaki N. The association of genotypic combination of the DRD3 and BDNF polymorphisms on the adhesio interthalamica and medial temporal lobe structures. Prog Neuropsychopharmacol Biol Psychiatry, 2008; 32: 1236-1242.
    8. Sukegawa M, Noda A, Soga T, Adachi Y, Tsuruta Y, Ozaki N, Koike Y. Comparison of sleep-disordered breathing and heart rate variability between hemodialysis and non-hemodialysis days in hemodialysis patients. Nagoya J Med Sci, 2008; 70: 83-88.
    9. Saito S, Takahashi N, Maeno N, Ito Y, Aleksic B, Usui H, Iidaka T, Inada T, Ozaki N. An association study of tachykinin receptor 3 gene with schizophrenia in the Japanese population. Neuroreport, 2008; 19: 471-473.
    10. Otani K, Ujike H, Sakai A, Okahisa Y, Kotaka T, Inada T, Harano M, Komiyama T, Hori T, Yamada M, Sekine Y, Iwata N, Iyo M, Sora I, Ozaki N, Kuroda S. Reduced CYP2D6 activity is a negative risk factor for methamphetamine dependence. Neurosci Lett, 2008; 434: 88-92.
    11. Okada T, Sato W, Kubota Y, Usui K, Inoue Y, Murai T, Hayashi T, Toichi M. Involvement of medial temporal structures in reflexive attentional shift by gaze. Soc Cogn Affect Neurosci, 2008; 3: 80-88.
    12. Ohtsuki T, Koga M, Ishiguro H, Horiuchi Y, Arai M, Niizato K, Itokawa M, Inada T, Iwata N, Iritani S, Ozaki N, Kunugi H, Ujike H, Watanabe Y, Someya T, Arinami T. A polymorphism of the metabotropic glutamate receptor mGluR7 (GRM7) gene is associated with schizophrenia. Schizophr Res, 2008; 101: 9-16.
    13. Ohtsuki T, Horiuchi Y, Koga M, Ishiguro H, Inada T, Iwata N, Ozaki N, Ujike H, Watanabe Y, Someya T, Arinami T. Association of polymorphisms in the haplotype block spanning the alternatively spliced exons of the NTNG1 gene at 1p13.3 with schizophrenia in Japanese populations. Neurosci Lett, 2008; 435: 194-197.
    14. Nunokawa A, Watanabe Y, Kitamura H, Kaneko N, Arinami T, Ujike H, Inada T, Iwata N, Kunugi H, Itokawa M, Ozaki N, Someya T. Large-scale case-control study of a functional polymorphism in the glutamate receptor, metabotropic 3 gene in patients with schizophrenia. Psychiatry Clin Neurosci, 2008; 62: 239-240.
    15. Niwa M, Nitta A, Cen X, Kitaichi K, Ozaki N, Yamada K, Nabeshima T. A novel molecule 'shati' increases dopamine uptake via the induction of tumor necrosis factor-alpha in pheochromocytoma-12 cells. J Neurochem, 2008; 107: 1697-1708.
    16. Morita Y, Ujike H, Tanaka Y, Kishimoto M, Okahisa Y, Kotaka T, Harano M, Inada T, Komiyama T, Hori T, Yamada M, Sekine Y, Iwata N, Iyo M, Sora I, Ozaki N, Kuroda S. The glycine transporter 1 gene (GLYT1) is associated with methamphetamine-use disorder. Am J Med Genet B Neuropsychiatr Genet, 2008; 147: 54-58.
    17. Miura H, Ozaki N, Shirokawa T, Isobe K. Changes in brain tryptophan metabolism elicited by ageing, social environment, and psychological stress in mice. Stress, 2008; 11: 160-169.
    18. Miura H, Ozaki N, Sawada M, Isobe K, Ohta T, Nagatsu T. A link between stress and depression: shifts in the balance between the kynurenine and serotonin pathways of tryptophan metabolism and the etiology and pathophysiology of depression. Stress, 2008; 11: 198-209.
    19. Masui T, Hashimoto R, Kusumi I, Suzuki K, Tanaka T, Nakagawa S, Suzuki T, Iwata N, Ozaki N, Kato T, Takeda M, Kunugi H, Koyama T. A possible association between missense polymorphism of the breakpoint cluster region gene and lithium prophylaxis in bipolar disorder. Prog Neuropsychopharmacol Biol Psychiatry, 2008; 32: 204-208.
    20. Kuratomi G, Iwamoto K, Bundo M, Kusumi I, Kato N, Iwata N, Ozaki N, Kato T. Aberrant DNA methylation associated with bipolar disorder identified from discordant monozygotic twins. Mol Psychiatry, 2008; 13: 429-441.
    21. Kotaka T, Ujike H, Morita Y, Kishimoto M, Okahisa Y, Inada T, Harano M, Komiyama T, Hori T, Yamada M, Sekine Y, Iwata N, Iyo M, Sora I, Ozaki N, Kuroda S. Association study between casein kinase 1 epsilon gene and methamphetamine dependence. Ann N Y Acad Sci, 2008; 1139: 43-48.
    22. Kishimoto M, Ujike H, Okahisa Y, Kotaka T, Takaki M, Kodama M, Inada T, Yamada M, Uchimura N, Iwata N, Sora I, Iyo M, Ozaki N, Kuroda S. The Frizzled 3 gene is associated with methamphetamine psychosis in the Japanese population. Behav Brain Funct, 2008; 4: 37.
    23. Kishimoto M, Ujike H, Motohashi Y, Tanaka Y, Okahisa Y, Kotaka T, Harano M, Inada T, Yamada M, Komiyama T, Hori T, Sekine Y, Iwata N, Sora I, Iyo M, Ozaki N, Kuroda S. The Dysbindin Gene (DTNBP1) Is Associated with Methamphetamine Psychosis. Biol Psychiatry, 2008; 63: 191-196.
    24. Kishi T, Kitajima T, Ikeda M, Yamanouchi Y, Kinoshita Y, Kawashima K, Okochi T, Ozaki N, Iwata N. Association analysis of nuclear receptor Rev-erb alpha gene (NR1D1) with mood disorders in the Japanese population. Neurosci Res, 2008; 62: 211-215.
    25. Kishi T, Ikeda M, Kitajima T, Yamanouchi Y, Kinoshita Y, Kawashima K, Okochi T, Inada T, Ozaki N, Iwata N. Genetic association analysis of tagging SNPs in alpha4 and beta2 subunits of neuronal nicotinic acetylcholine receptor genes (CHRNA4 and CHRNB2) with schizophrenia in the Japanese population. J Neural Transm, 2008; 115: 1457-1461.
    26. Kishi T, Ikeda M, Kitajima T, Yamanouchi Y, Kinoshita Y, Kawashima K, Inada T, Harano M, Komiyama T, Hori T, Yamada M, Iyo M, Sora I, Sekine Y, Ozaki N, Ujike H, Iwata N. Prostate apoptosis response 4 gene is not associated with methamphetamine-use disorder in the Japanese population. Ann N Y Acad Sci, 2008; 1139: 83-88.
    27. Kishi T, Ikeda M, Kitajima T, Yamanouchi Y, Kinoshita Y, Kawashima K, Inada T, Harano M, Komiyama T, Hori T, Yamada M, Iyo M, Sora I, Sekine Y, Ozaki N, Ujike H, Iwata N. Alpha4 and beta2 subunits of neuronal nicotinic acetylcholine receptor genes are not associated with methamphetamine-use disorder in the Japanese population. Ann N Y Acad Sci, 2008; 1139: 70-82.
    28. Kishi T, Ikeda M, Kitajima T, Yamanouchi Y, Kinoshita Y, Kawashima K, Inada T, Harano M, Komiyama T, Hori T, Yamada M, Iyo M, Sora I, Sekine Y, Ozaki N, Ujike H, Iwata N. Glutamate cysteine ligase modifier (GCLM) subunit gene is not associated with methamphetamine-use disorder or schizophrenia in the Japanese population. Ann N Y Acad Sci, 2008; 1139: 63-69.
    29. Kishi T, Ikeda M, Kitajima T, Suzuki T, Yamanouchi Y, Kinoshita Y, Kawashima K, Ozaki N, Iwata N. No association between prostate apoptosis response 4 gene (PAWR) in schizophrenia and mood disorders in a Japanese population. Am J Med Genet B Neuropsychiatr Genet, 2008; 147B: 531-534.
    30. Kinoshita Y, Ikeda M, Ujike H, Kitajima T, Yamanouchi Y, Aleksic B, Kishi T, Kawashima K, Ohkouchi T, Ozaki N, Inada T, Harano M, Komiyama T, Hori T, Yamada M, Sekine Y, Iyo M, Sora I, Iwata N. Association study of the calcineurin A gamma subunit gene (PPP3CC) and methamphetamine-use disorder in a Japanese population. Ann N Y Acad Sci, 2008; 1139: 57-62.
    31. Kawashima K, Kishi T, Ikeda M, Kitajima T, Yamanouchi Y, Kinoshita Y, Takahashi N, Saito S, Ohi K, Yasuda Y, Hashimoto R, Takeda M, Inada T, Ozaki N, Iwata N. No association between tagging SNPs of SNARE complex genes (STX1A, VAMP2 and SNAP25) and schizophrenia in a Japanese population. Am J Med Genet B Neuropsychiatr Genet, 2008; 147B: 1327-1331.
    32. Kanahara N, Miyatake R, Sekine Y, Inada T, Ozaki N, Iwata N, Harano M, Komiyama T, Yamada M, Sora I, Ujike H, Iyo M, Hashimoto K. Association study between the PIK4CA gene and methamphetamine use disorder in a Japanese population. Am J Med Genet B Neuropsychiatr Genet, 2008; 150B: 233-238.
    33. Kakiuchi C, Ishiwata M, Nanko S, Ozaki N, Iwata N, Umekage T, Tochigi M, Kohda K, Sasaki T, Imamura A, Okazaki Y, Kato T. Up-regulation of ADM and SEPX1 in the lymphoblastoid cells of patients in monozygotic twins discordant for schizophrenia. Am J Med Genet B Neuropsychiatr Genet, 2008; 147B: 557-564.
    34. Ji X, Takahashi N, Saito S, Ishihara R, Maeno N, Inada T, Ozaki N. Relationship between three serotonin receptor subtypes (HTR3A, HTR2A and HTR4) and treatment-resistant schizophrenia in the Japanese population. Neurosci Lett, 2008; 435: 95-98.
    35. Ji X, Takahashi N, Branko A, Ishihara R, Nagai T, Mouri A, Saito S, Maeno N, Inada T, Ozaki N. An association between serotonin receptor 3B gene (HTR3B) and treatment-resistant schizophrenia (TRS) in a Japanese population. Nagoya J Med Sci, 2008; 70: 11-17.
    36. Iwamoto K, Takahashi M, Nakamura Y, Kawamura Y, Ishihara R, Uchiyama Y, Ebe K, Noda A, Noda Y, Yoshida K, Iidaka T, Ozaki N. The effects of acute treatment with paroxetine, amitriptyline, and placebo on driving performance and cognitive function in healthy Japanese subjects: a double-blind crossover trial. Hum Psychopharmacol, 2008; 23: 399-407.
    37. Iwamoto K, Kawamura Y, Takahashi M, Uchiyama Y, Ebe K, Yoshida K, Iidaka T, Noda Y, Ozaki N. Plasma amitriptyline level after acute administration, and driving performance in healthy volunteers. Psychiatry Clin Neurosci, 2008; 62: 610-616.
    38. Ito Y, Yamada S, Takahashi N, Saito S, Yoshimi A, Inada T, Noda Y, Ozaki N. No association between the protein tyrosine phosphatase, receptor-type, Z Polypeptide 1 (PTPRZ1) gene and schizophrenia in the Japanese population. Am J Med Genet B Neuropsychiatr Genet, 2008; 147B: 1013-1018.
    39. Ito Y, Nakamura Y, Takahashi N, Saito S, Aleksic B, Iwata N, Inada T, Ozaki N. A genetic association study of the FXYD domain containing ion transport regulator 6 (FXYD6) gene, encoding phosphohippolin, in susceptibility to schizophrenia in a Japanese population. Neurosci Lett, 2008; 438: 70-75.
    40. Ishiguro H, Imai K, Koga M, Horiuchi Y, Inada T, Iwata N, Ozaki N, Ujike H, Itokawa M, Kunugi H, Sasaki T, Watanabe Y, Someya T, Arinami T. Replication study for associations between polymorphisms in the CLDN5 and DGCR2 genes in the 22q11 deletion syndrome region and schizophrenia. Psychiatr Genet, 2008; 18: 255-256.
    41. Inada T, Koga M, Ishiguro H, Horiuchi Y, Syu A, Yoshio T, Takahashi N, Ozaki N, Arinami T. Pathway-based association analysis of genome-wide screening data suggest that genes associated with the gamma-aminobutyric acid receptor signaling pathway are involved in neuroleptic-induced, treatment-resistant tardive dyskinesia. Pharmacogenet Genomics, 2008; 18: 317-323.
    42. Ikeda M, Yamanouchi Y, Kinoshita Y, Kitajima T, Yoshimura R, Hashimoto S, O'Donovan MC, Nakamura J, Ozaki N, Iwata N. Variants of dopamine and serotonin candidate genes as predictors of response to risperidone treatment in first-episode schizophrenia. Pharmacogenomics, 2008; 9: 1437-1443.
    43. Ikeda M, Takahashi N, Saito S, Aleksic B, Watanabe Y, Nunokawa A, Yamanouchi Y, Kitajima T, Kinoshita Y, Kishi T, Kawashima K, Hashimoto R, Ujike H, Inada T, Someya T, Takeda M, Ozaki N, Iwata N. Failure to replicate the association between NRG1 and schizophrenia using Japanese large sample. Schizophr Res, 2008; 101: 1-8.
    44. Ikeda M, Hikita T, Taya S, Uraguchi-Asaki J, Toyo-oka K, Wynshaw-Boris A, Ujike H, Inada T, Takao K, Miyakawa T, Ozaki N, Kaibuchi K, Iwata N. Identification of YWHAE, a gene encoding 14-3-3epsilon, as a possible susceptibility gene for schizophrenia. Hum Mol Genet, 2008; 17: 3212-3222.
    45. Hashimoto T, Hashimoto K, Miyatake R, Matsuzawa D, Sekine Y, Inada T, Ozaki N, Iwata N, Harano M, Komiyama T, Yamada M, Sora I, Ujike H, Iyo M. Association study between polymorphisms in glutathione-related genes and methamphetamine use disorder in a Japanese population. Am J Med Genet B Neuropsychiatr Genet, 2008; 147B: 1040-1046.
    46. Deng X, Sagata N, Takeuchi N, Tanaka M, Ninomiya H, Iwata N, Ozaki N, Shibata H, Fukumaki Y. Association study of polymorphisms in the neutral amino acid transporter genes SLC1A4, SLC1A5 and the glycine transporter genes SLC6A5, SLC6A9 with schizophrenia. BMC Psychiatry, 2008; 8: 58.
    47. Aleksic B, Ikeda M, Ishihara R, Saito S, Inada T, Iwata N, Ozaki N. No association between the oligodendrocyte-related gene PLP1 and schizophrenia in the Japanese population. J Hum Genet, 2008; 53: 863-866.
    48. Albalushi T, Horiuchi Y, Ishiguro H, Koga M, Inada T, Iwata N, Ozaki N, Ujike H, Watanabe Y, Someya T, Arinami T. Replication study and meta-analysis of the genetic association of GRM3 gene polymorphisms with schizophrenia in a large Japanese case-control population. Am J Med Genet B Neuropsychiatr Genet, 2008; 147: 392-396.
  • 2007年
    1. Yoshida K, Higuchi H, Ozaki N. Successful treatment of severe antidepressant-induced nausea with a combination of milnacipran and olanzapine. Pharmacopsychiatry, 2007; 40: 84-85.
    2. Yoshida K, Higuchi H, Kamata M, Takahashi H, Inoue K, Suzuki T, Itoh K, Ozaki N. The G196A polymorphism of the brain-derived neurotrophic factor gene and the antidepressant effect of milnacipran and fluvoxamine. J Psychopharmacol, 2007; 21: 650-656.
    3. Urata T, Takahashi N, Hakamata Y, Iijima Y, Kuwahara N, Ozaki N, Ono Y, Amano M, Inada T. Gene-gene interaction analysis of personality traits in a Japanese population using an electrochemical DNA array chip analysis. Neurosci Lett, 2007; 414: 209-212.
    4. Tomita Y, Ikeda M, Mutoh H, Inada T, Iwata N, Ozaki N, Honda H. Association study between Apolipoprotein L and schizophrenia by exhaustive and rule-based combination analysis for identification of multilocus interactions. J Biosci Bioeng, 2007; 103: 303-310.
    5. Tabuse H, Kalali A, Azuma H, Ozaki N, Iwata N, Naitoh H, Higuchi T, Kanba S, Shioe K, Akechi T, Furukawa TA. The new GRID Hamilton Rating Scale for Depression demonstrates excellent inter-rater reliability for inexperienced and experienced raters before and after training. Psychiatry Res, 2007; 153: 61-67.
    6. Sato W, Okada T, Toichi M. Attentional shift by gaze is triggered without awareness. Exp Brain Res, 2007; 183: 87-94.
    7. Saito S, Takahashi N, Ishihara R, Ikeda M, Suzuki T, Kitajima T, Yamanouchi Y, Iwata N, Yamada M, Yoshida K, Inada T, Ozaki N. Association Study between Vesicle-Associated Membrane Protein 2 Gene Polymorphisms and Fluvoxamine Response in Japanese Major Depressive Patients. Neuropsychobiology, 2007; 54: 226-230.
    8. Ohnishi T, Yamada K, Ohba H, Iwayama Y, Toyota T, Hattori E, Inada T, Kunugi H, Tatsumi M, Ozaki N, Iwata N, Sakamoto K, Iijima Y, Iwata Y, Tsuchiya KJ, Sugihara G, Nanko S, Osumi N, Detera-Wadleigh SD, Kato T, Yoshikawa T. A Promoter Haplotype of the Inositol Monophosphatase 2 Gene (IMPA2) at 18p11.2 Confers a Possible Risk for Bipolar Disorder by Enhancing Transcription. Neuropsychopharmacology, 2007; 32: 1727-1737.
    9. Nakayama H, Kitaichi K, Ito Y, Hashimoto K, Takagi K, Yokoi T, Ozaki N, Yamamoto T, Hasegawa T. The role of organic cation transporter-3 in methamphetamine disposition and its behavioral response in rats. Brain Res, 2007; 1184: 260-269.
    10. Mouri A, Noda Y, Noda A, Nakamura T, Tokura T, Yura Y, Nitta A, Furukawa H, Nabeshima T. Involvement of a dysfunctional dopamine-D1/N-methyl-d-aspartate-NR1 and Ca2+/calmodulin-dependent protein kinase II pathway in the impairment of latent learning in a model of schizophrenia induced by phencyclidine. Mol Pharmacol, 2007; 71: 1598-1609.
    11. Miura H, Kitagami T, Ozaki N. Suppressive effect of paroxetine, a selective serotonin uptake inhibitor, on tetrahydrobiopterin levels and dopamine as well as serotonin turnover in the mesoprefrontal system of mice. Synapse, 2007; 61: 698-706.
    12. Matsuzawa D, Hashimoto K, Miyatake R, Shirayama Y, Shimizu E, Maeda K, Suzuki Y, Mashimo Y, Sekine Y, Inada T, Ozaki N, Iwata N, Harano M, Komiyama T, Yamada M, Sora I, Ujike H, Hata A, Sawa A, Iyo M. Identification of Functional Polymorphisms in the Promoter Region of the Human PICK1 Gene and Their Association With Methamphetamine Psychosis. Am J Psychiatry, 2007; 164: 1105-1114.
    13. Maeno N, Takahashi N, Saito S, Ji X, Ishihara R, Aoyama N, Branko A, Miura H, Ikeda M, Suzuki T, Kitajima T, Yamanouchi Y, Kinoshita Y, Iwata N, Inada T, Ozaki N. Association of SOX10 with schizophrenia in the Japanese population. Psychiatr Genet, 2007; 17: 227-231.
    14. Maeno N, Takahashi N, Saito S, Ji X, Branko A, Ishihara R, Yoshida K, Inada T, Iidaka T, Ozaki N. Association study between the transferrin gene and schizophrenia in the Japanese population. Neuroreport, 2007; 18: 517-520.
    15. Koga M, Ishiguro H, Horiuchi Y, Albalushi T, Inada T, Iwata N, Ozaki N, Ujike H, Muratake T, Someya T, Arinami T. Failure to confirm the association between the FEZ1 gene and schizophrenia in a Japanese population. Neurosci Lett, 2007; 417: 326-329.
    16. Kimura H, Tonoike T, Muroya T, Yoshida K, Ozaki N. Age of onset has limited association with body mass index at time of presentation for anorexia nervosa: Comparison of peak-onset and late-onset anorexia nervosa groups. Psychiatry Clin Neurosci, 2007; 61: 646-650.
    17. Ito M, Yoshida K, Kimura H, Ozaki N, Kurita K. Successful Treatment of Trigeminal Neuralgia With Milnacipran. Clin Neuropharmacol, 2007; 30: 183-185.
    18. Ishiguro H, Koga M, Horiuchi Y, Inada T, Iwata N, Ozaki N, Ujike H, Muratake T, Someya T, Arinami T. PICK1 is not a susceptibility gene for schizophrenia in a Japanese population: Association study in a large case-control population. Neurosci Res, 2007; 58: 145-148.
    19. Ishiguro H, Horiuchi Y, Koga M, Inada T, Iwata N, Ozaki N, Ujike H, Muratake T, Someya T, Arinami T. RGS4 is not a susceptibility gene for schizophrenia in Japanese: association study in a large case-control population. Schizophr Res, 2007; 89: 161-164.
    20. Ikeda M, Ozaki N, Yamanouchi Y, Suzuki T, Kitajima T, Kinoshita Y, Inada T, Iwata N. No association between the glutamate decarboxylase 67 gene (GAD1) and schizophrenia in the Japanese population. Schizophr Res, 2007; 91: 22-26.
    21. Ikeda M, Ozaki N, Suzuki T, Kitajima T, Yamanouchi Y, Kinoshita Y, Kishi T, Sekine Y, Iyo M, Harano M, Komiyama T, Yamada M, Sora I, Ujike H, Inada T, Iwata N. Possible association of beta-arrestin 2 gene with methamphetamine use disorder, but not schizophrenia. Genes Brain Behav, 2007; 6: 107-112.
    22. Horiuchi Y, Ishiguro H, Koga M, Inada T, Iwata N, Ozaki N, Ujike H, Muratake T, Someya T, Arinami T. Support for association of the PPP3CC gene with schizophrenia. Mol Psychiatry, 2007; 12: 891-893.
    23. Hashimoto R, Hashimoto H, Shintani N, Chiba S, Hattori S, Okada T, Nakajima M, Tanaka K, Kawagishi N, Nemoto K, Mori T, Ohnishi T, Noguchi H, Hori H, Suzuki T, Iwata N, Ozaki N, Nakabayashi T, Saitoh O, Kosuga A, Tatsumi M, Kamijima K, Weinberger DR, Kunugi H, Baba A. Pituitary adenylate cyclase-activating polypeptide is associated with schizophrenia. Mol Psychiatry, 2007; 12: 1026-1032.
    24. Deng X, Shibata H, Takeuchi N, Rachi S, Sakai M, Ninomiya H, Iwata N, Ozaki N, Fukumaki Y. Association study of polymorphisms in the glutamate transporter genes SLC1A1, SLC1A3, and SLC1A6 with schizophrenia. Am J Med Genet B Neuropsychiatr Genet, 2007; 144: 271-278.
    25. Aleksic B, Ishihara R, Takahashi N, Maeno N, Ji X, Saito S, Inada T, Ozaki N. Gap junction coding genes and schizophrenia: a genetic association study. J Hum Genet, 2007; 52: 498-501.
  • 2006年
    1. Usui H, Takahashi N, Saito S, Ishihara R, Aoyama N, Ikeda M, Suzuki T, Kitajima T, Yamanouchi Y, Kinoshita Y, Yoshida K, Iwata N, Inada T, Ozaki N. The 2',3'-cyclic nucleotide 3'-phosphodiesterase and oligodendrocyte lineage transcription factor 2 genes do not appear to be associated with schizophrenia in the Japanese population. Schizophr Res, 2006; 88: 245-250.
    2. Ujike H, Sakai A, Nakata K, Tanaka Y, Kodaka T, Okahisa Y, Harano M, Inada T, Yamada M, Komiyama T, Hori T, Sekine Y, Iwata N, Sora I, Iyo M, Ozaki N, Kuroda S. Association Study of the Dihydropyrimidinase-Related Protein 2 Gene and Methamphetamine Psychosis. Ann N Y Acad Sci, 2006; 1074: 90-96.
    3. Takahashi N, Ishihara R, Saito S, Maemo N, Aoyama N, Ji X, Miura H, Ikeda M, Iwata N, Suzuki T, Kitajima T, Yamanouchi Y, Kinoshita Y, Ozaki N, Inada T. Association between chromogranin A gene polymorphism and schizophrenia in the Japanese population. Schizophr Res, 2006; 83: 179-183.
    4. Suzuki A, Nakamura K, Sekine Y, Minabe Y, Takei N, Suzuki K, Iwata Y, Kawai M, Takebayashi K, Matsuzaki H, Iyo M, Ozaki N, Inada T, Iwata N, Harano M, Komiyama T, Yamada M, Sora I, Ujike H, Mori N. An association study between catechol-O-methyl transferase gene polymorphism and methamphetamine psychotic disorder. Psychiatr Genet, 2006; 16: 133-138.
    5. Shibata H, Aramaki T, Sakai M, Ninomiya H, Tashiro N, Iwata N, Ozaki N, Fukumaki Y. Association study of polymorphisms in the GluR7, KA1 and KA2 kainate receptor genes (GRIK3, GRIK4, GRIK5) with schizophrenia. Psychiatry Res, 2006; 141: 39-51.
    6. Okada T, Sato W, Toichi M. Right hemispheric dominance in gaze-triggered reflexive shift of attention in humans. Brain Cogn, 2006; 62: 128-133.
    7. Nomura A, Ujike H, Tanaka Y, Otani K, Morita Y, Kishimoto M, Morio A, Harano M, Inada T, Yamada M, Komiyama T, Sekine Y, Iwata N, Sora I, Iyo M, Ozaki N, Kuroda S. Genetic variant of prodynorphin gene is risk factor for methamphetamine dependence. Neurosci Lett, 2006; 400: 158-162.
    8. Nomura A, Ujike H, Tanaka Y, Kishimoto M, Otani K, Morita Y, Morio A, Harano M, Inada T, Yamada M, Komiyama T, Hori T, Sekine Y, Iwata N, Sora I, Iyo M, Ozaki N, Kuroda S. Association Study of the Tumor Necrosis Factor-{alpha} Gene and Its 1A Receptor Gene with Methamphetamine Dependence. Ann N Y Acad Sci, 2006; 1074: 116-124.
    9. Noda A, Nakai S, Soga T, Sugiura T, Iwayama N, Maeda K, Atarashi M, Yasuma F, Ozaki N, Yokota M, Koike Y. Factors contributing to sleep disturbance and hypnotic drug use in hemodialysis patients. Intern Med, 2006; 45: 1273-1278.
    10. Nakamura K, Chen CK, Sekine Y, Iwata Y, Anitha A, Loh el W, Takei N, Suzuki A, Kawai M, Takebayashi K, Suzuki K, Minabe Y, Tsuchiya K, Yamada K, Iyo M, Ozaki N, Inada T, Iwata N, Harano M, Komiyama T, Yamada M, Sora I, Ujike H, Ball DM, Yoshikawa T, Lin SK, Mori N. Association analysis of SOD2 variants with methamphetamine psychosis in Japanese and Taiwanese populations. Hum Genet, 2006; 120: 243-252.
    11. Nakajima A, Kamitsuji S, Saito A, Tanaka E, Nishimura K, Horikawa N, Ozaki N, Tomatsu T, Hara M, Kamatani N, Yamanaka H. Disability and patient's appraisal of general health contribute to depressed mood in rheumatoid arthritis in a large clinical study in Japan. Mod Rheumatol, 2006; 16: 151-157.
    12. Morio A, Ujike H, Nomura A, Tanaka Y, Morita Y, Otani K, Kishimoto M, Harano M, Inada T, Komiyama T, Yamada M, Sekine Y, Iwata N, Iyo M, Sora I, Ozaki N, Kuroda S. No Association between CART (Cocaine- and Amphetamine-Regulated Transcript) Gene and Methamphetamine Dependence. Ann N Y Acad Sci, 2006; 1074: 411-417.
    13. Masui T, Hashimoto R, Kusumi I, Suzuki K, Tanaka T, Nakagawa S, Suzuki T, Iwata N, Ozaki N, Kato T, Kunugi H, Koyama T. Lithium response and Val66Met polymorphism of the brain-derived neurotrophic factor gene in Japanese patients with bipolar disorder. Psychiatr Genet, 2006; 16: 49-50.
    14. Kobayashi H, Hata H, Ujike H, Harano M, Inada T, Komiyama T, Yamada M, Sekine Y, Iwata N, Iyo M, Ozaki N, Itokawa M, Naka M, Ide S, Ikeda K, Numachi Y, Sora I. Association analysis of delta-opioid receptor gene polymorphisms in methamphetamine dependence/psychosis. Am J Med Genet B Neuropsychiatr Genet, 2006; 141: 482-486.
    15. Kishi T, Ikeda M, Suzuki T, Kitajima T, Yamanouchi Y, Kinoshita Y, Ozaki N, Iwata N. No association of complexin1 and complexin2 genes with schizophrenia in a Japanese population. Schizophr Res, 2006; 82: 185-189.
    16. Kimura H, Ozaki N. Diagnosis and treatment of depression in dialysis patients. Ther Apher Dial, 2006; 10: 328-332.
    17. Ikeda M, Iwata N, Suzuki T, Kitajima T, Yamanouchi Y, Kinoshiya Y, Sekine Y, Iyo M, Harano M, Komiyama T, Yamada M, Sora I, Ujike H, Inada T, Ozaki N. Positive association of AKT1 haplotype to Japanese methamphetamine use disorder. Int J Neuropsychopharmacol, 2006; 9: 77-81.
    18. Ikeda M, Iwata N, Suzuki T, Kitajima T, Yamanouchi Y, Kinoshita Y, Ozaki N. No association of serotonin transporter gene (SLC6A4) with schizophrenia and bipolar disorder in Japanese patients: association analysis based on linkage disequilibrium. J Neural Transm, 2006; 113: 899-905.
    19. Ikeda M, Iwata N, Kitajima T, Suzuki T, Yamanouchi Y, Kinoshita Y, Ozaki N. Positive association of the serotonin 5-HT7 receptor gene with schizophrenia in a Japanese population. Neuropsychopharmacology, 2006; 31: 866-871.
    20. Iidaka T, Matsumoto A, Ozaki N, Suzuki T, Iwata N, Yamamoto Y, Okada T, Sadato N. Volume of left amygdala subregion predicted temperamental trait of harm avoidance in female young subjects. A voxel-based morphometry study. Brain Res, 2006; 1125: 85-93.
    21. Ide S, Kobayashi H, Ujike H, Ozaki N, Sekine Y, Inada T, Harano M, Komiyama T, Yamada M, Iyo M, Iwata N, Tanaka K, Shen H, Iwahashi K, Itokawa M, Minami M, Satoh M, Ikeda K, Sora I. Linkage disequilibrium and association with methamphetamine dependence/psychosis of mu-opioid receptor gene polymorphisms. Pharmacogenomics J, 2006; 6: 179-188.
    22. Hashimoto R, Numakawa T, Ohnishi T, Kumamaru E, Yagasaki Y, Ishimoto T, Mori T, Nemoto K, Adachi N, Izumi A, Chiba S, Noguchi H, Suzuki T, Iwata N, Ozaki N, Taguchi T, Kamiya A, Kosuga A, Tatsumi M, Kamijima K, Weinberger DR, Sawa A, Kunugi H. Impact of the DISC1 Ser704Cys polymorphism on risk for major depression, brain morphology and ERK signaling. Hum Mol Genet, 2006; 15: 3024-3033.
    23. Hakamata Y, Iwase M, Iwata H, Kobayashi T, Tamaki T, Nishio M, Kawahara K, Matsuda H, Ozaki N, Honjo S, Inada T. Regional brain cerebral glucose metabolism and temperament: a positron emission tomography study. Neurosci Lett, 2006; 396: 33-37.
    24. Aoyama N, Takahashi N, Saito S, Maeno N, Ishihara R, Ji X, Miura H, Ikeda M, Suzuki T, Kitajima T, Yamanouchi Y, Kinoshita Y, Yoshida K, Iwata N, Inada T, Ozaki N. Association study between kynurenine 3-monooxygenase gene and schizophrenia in the Japanese population. Genes Brain Behav, 2006; 5: 364-368.
    25. Aoyama N, Takahashi N, Kitaichi K, Ishihara R, Saito S, Maeno N, Ji X, Takagi K, Sekine Y, Iyo M, Harano M, Komiyama T, Yamada M, Sora I, Ujike H, Iwata N, Inada T, Ozaki N. Association between gene polymorphisms of SLC22A3 and methamphetamine use disorder. Alcohol Clin Exp Res, 2006; 30: 1644-1649.
    26. Ando T, Komaki G, Naruo T, Okabe K, Takii M, Kawai K, Konjiki F, Takei M, Oka T, Takeuchi K, Masuda A, Ozaki N, Suematsu H, Denda K, Kurokawa N, Itakura K, Yamaguchi C, Kono M, Suzuki T, Nakai Y, Nishizono-Maher A, Koide M, Murakami K, Nagamine K, Tomita Y, Ookuma K, Tomita K, Tonai E, Ooshima A, Ishikawa T, Ichimaru Y. Possible role of preproghrelin gene polymorphisms in susceptibility to bulimia nervosa. Am J Med Genet B Neuropsychiatr Genet, 2006; 141: 929-934.
  • 2005年
    1. Saito S, Ikeda M, Iwata N, Suzuki T, Kitajima T, Yamanouchi Y, Kinoshita Y, Takahashi N, Inada T, Ozaki N. No association was found between a functional SNP in ZDHHC8 and schizophrenia in a Japanese case-control population. Neurosci Lett, 2005; 374: 21-24.
    2. Ohgake S, Hashimoto K, Shimizu E, Koizumi H, Okamura N, Koike K, Matsuzawa D, Sekine Y, Inada T, Ozaki N, Iwata N, Harano M, Komiyama T, Yamada M, Sora I, Ujike H, Shirayama Y, Iyo M. Functional polymorphism of the NQO2 gene is associated with methamphetamine psychosis. Addict Biol, 2005; 10: 145-148.
    3. Nishiyama T, Ikeda M, Iwata N, Suzuki T, Kitajima T, Yamanouchi Y, Sekine Y, Iyo M, Harano M, Komiyama T, Yamada M, Sora I, Ujike H, Inada T, Furukawa T, Ozaki N. Haplotype association between GABAA receptor gamma2 subunit gene (GABRG2) and methamphetamine use disorder. Pharmacogenomics J, 2005; 5: 89-95.
    4. Morita Y, Ujike H, Tanaka Y, Uchida N, Nomura A, Otani K, Kishimoto M, Morio A, Inada T, Harano M, Komiyama T, Yamada M, Sekine Y, Iwata N, Iyo M, Sora I, Ozaki N. The X-box binding protein 1 (XBP1) gene is not associated with methamphetamine dependence. Neurosci Lett, 2005; 383: 194-198.
    5. Morita Y, Ujike H, Tanaka Y, Uchida N, Nomura A, Ohtani K, Kishimoto M, Morio A, Imamura T, Sakai A, Inada T, Harano M, Komiyama T, Yamada M, Sekine Y, Iwata N, Iyo M, Sora I, Ozaki N, Kuroda S. A nonsynonymous polymorphism in the human fatty acid amide hydrolase gene did not associate with either methamphetamine dependence or schizophrenia. Neurosci Lett, 2005; 376: 182-187.
    6. Miura H, Qiao H, Kitagami T, Ohta T, Ozaki N. Fluvoxamine, a selective serotonin reuptake inhibitor, suppresses tetrahydrobiopterin levels and dopamine as well as serotonin turnover in the mesoprefrontal system of mice. Psychopharmacology (Berl), 2005; 177: 307-314.
    7. Miura H, Qiao H, Kitagami T, Ohta T, Ozaki N. Effects of fluvoxamine on levels of dopamine, serotonin, and their metabolites in the hippocampus elicited by isolation housing and novelty stress in adult rats. Int J Neurosci, 2005; 115: 367-378.
    8. Maeno N, Kusunoki K, Kitajima T, Iwata N, Ono Y, Hashimoto S, Imai M, Li L, Kayukawa Y, Ohta T, Ozaki N. Personality of seasonal affective disorder analyzed by Tri-dimensional Personality Questionnaire. J Affect Disord, 2005; 85: 267-273.
    9. Kinoshita Y, Suzuki T, Ikeda M, Kitajima T, Yamanouchi Y, Inada T, Yoneda H, Iwata N, Ozaki N. No association with the calcineurin A gamma subunit gene (PPP3CC) haplotype to Japanese schizophrenia. J Neural Transm, 2005; 112: 1255-1262.
    10. Ikeda M, Iwata N, Suzuki T, Kitajima T, Yamanouchi Y, Kinoshita Y, Ozaki N. No association of GSK3beta gene (GSK3B) with Japanese schizophrenia. Am J Med Genet B Neuropsychiatr Genet, 2005; 134: 90-92.
    11. Ikeda M, Iwata N, Suzuki T, Kitajima T, Yamanouchi Y, Kinoshita Y, Inada T, Ujike H, Ozaki N. Association Analysis of Chromosome 5 GABA(A) Receptor Cluster in Japanese Schizophrenia Patients. Biol Psychiatry, 2005; 58: 440-445.
    12. Ikeda M, Iwata N, Suzuki T, Kitajima T, Yamanouchi Y, Kinoshita Y, Inada T, Ozaki N. No association of haplotype-tagging SNPs in TRAR4 with schizophrenia in Japanese patients. Schizophr Res, 2005; 78: 127-130.
    13. Iidaka T, Ozaki N, Matsumoto A, Nogawa J, Kinoshita Y, Suzuki T, Iwata N, Yamamoto Y, Okada T, Sadato N. A variant C178T in the regulatory region of the serotonin receptor gene HTR3A modulates neural activation in the human amygdala. J Neurosci, 2005; 25: 6460-6466.
    14. Hashimoto T, Hashimoto K, Matsuzawa D, Shimizu E, Sekine Y, Inada T, Ozaki N, Iwata N, Harano M, Komiyama T, Yamada M, Sora I, Ujike H, Iyo M. A functional glutathione S-transferase P1 gene polymorphism is associated with methamphetamine-induced psychosis in Japanese population. Am J Med Genet B Neuropsychiatr Genet, 2005; 135B: 5-9.
    15. Hashimoto R, Yoshida M, Ozaki N, Yamanouchi Y, Iwata N, Suzuki T, Kitajima T, Tatsumi M, Kamijima K, Kunugi H. A missense polymorphism (H204R) of a Rho GTPase-activating protein, the chimerin 2 gene, is associated with schizophrenia in men. Schizophr Res, 2005; 73: 383-385.
    16. Hashimoto R, Suzuki T, Iwata N, Yamanouchi Y, Kitajima T, Kosuga A, Tatsumi M, Ozaki N, Kamijima K, Kunugi H. Association study of the frizzled-3 (FZD3) gene with schizophrenia and mood disorders. J Neural Transm, 2005; 112: 303-307.
    17. Hakamata Y, Takahashi N, Ishihara R, Saito S, Ozaki N, Honjo S, Ono Y, Inada T. No association between monoamine oxidase A promoter polymorphism and personality traits in Japanese females. Neurosci Lett, 2005; 389: 121-123.
    18. Furukawa TA, Streiner DL, Azuma H, Higuchi T, Kamijima K, Kanba S, Ozaki N, Aoba A, Murasaki M, Miura S. Cross-cultural equivalence in depression assessment: Japan-Europe-North American study. Acta Psychiatr Scand, 2005; 112: 279-285.
    19. Arinami T, Ohtsuki T, Ishiguro H, Ujike H, Tanaka Y, Morita Y, Mineta M, Takeichi M, Yamada S, Imamura A, Ohara K, Shibuya H, Suzuki Y, Muratake T, Kaneko N, Someya T, Inada T, Yoshikawa T, Toyota T, Yamada K, Kojima T, Takahashi S, Osamu O, Shinkai T, Nakamura M, Fukuzako H, Hashiguchi T, Niwa SI, Ueno T, Tachikawa H, Hori T, Asada T, Nanko S, Kunugi H, Hashimoto R, Ozaki N, Iwata N, Harano M, Arai H, Ohnuma T, Kusumi I, Koyama T, Yoneda H, Fukumaki Y, Shibata H, Kaneko S, Higuchi H, Yasui-Furukori N, Numachi Y, Itokawa M, Okazaki Y. Genomewide high-density SNP linkage analysis of 236 Japanese families supports the existence of schizophrenia susceptibility Loci on chromosomes 1p, 14q, and 20p. Am J Hum Genet, 2005; 77: 937-944.
    20. Arima M, Shimizu Y, Sowa J, Narita T, Nishi I, Iwata N, Ozaki N, Hashimoto S, Matsunaga K. Psychosomatic analysis of atopic dermatitis using a psychological test. J Dermatol, 2005; 32: 160-168.
  • 2004年
    1. Takano A, Uchiyama M, Kajimura N, Mishima K, Inoue Y, Kamei Y, Kitajima T, Shibui K, Katoh M, Watanabe T, Hashimotodani Y, Ozeki Y, Hori T, Yamada N, Toyoshima R, Ozaki N, Okawa M, Nagai K, Takahashi K, Isojima Y, Yamauchi T, Ebisawa T. A Missense Variation in Human Casein Kinase I Epsilon Gene that Induces Functional Alteration and Shows an Inverse Association with Circadian Rhythm Sleep Disorders. Neuropsychopharmacology, 2004; 29: 1901-1909.
    2. Ozaki N. Pharmacogenetics of antipsychotics. Nagoya J Med Sci, 2004; 67: 1-7.
    3. Okada M, Northup J, Ozaki N, Russell J, Linnoila M, Goldman D. Modification of Human 5-HT2C Receptor Function by Cys23Ser, an Abundant, Naturally Occurring Amino Acid Substitution. Mol Psychiatry, 2004; 9: 55-64.
    4. Okada M, Goldman D, Linnoila M, Iwata N, Ozaki N, Northup JK. Comparison of G-Protein Selectivity of Human 5-HT2C and 5-HT1A Receptors. Ann N Y Acad Sci, 2004; 1025: 570-577.
    5. Numakawa T, Yagasaki Y, Ishimoto T, Okada T, Suzuki T, Iwata N, Ozaki N, Taguchi T, Tatsumi M, Kamijima K, Straub RE, Weinberger DR, Kunugi H, Hashimoto R. Evidence of novel neuronal functions of dysbindin, a susceptibility gene for schizophrenia. Hum Mol Genet, 2004; 13: 2699-2708.
    6. Nokura K, Kanbayashi T, Ozeki T, Koga H, Zettsu T, Yamamoto H, Ozaki N, Shimizu T, Kawase T. Hypersomnia, asterixis and cataplexy in association with orexin A-reduced hypothalamic tumor. J Neurol, 2004; 251: 1534-1535.
    7. Munakata K, Tanaka M, Mori K, Washizuka S, Yoneda M, Tajima O, Akiyama T, Nanko S, Kunugi H, Tadokoro K, Ozaki N, Inada T, Sakamoto K, Fukunaga T, Iijima Y, Iwata N, Tatsumi M, Yamada K, Yoshikawa T, Kato T. Mitochondrial DNA 3644T-->C mutation associated with bipolar disorder. Genomics, 2004; 84: 1041-1050.
    8. Kunugi H, Iijima Y, Tatsumi M, Yoshida M, Hashimoto R, Kato T, Sakamoto K, Fukunaga T, Inada T, Suzuki T, Iwata N, Ozaki N, Yamada K, Yoshikawa T. No association between the Val66Met polymorphism of the brain-derived neurotrophic factor gene and bipolar disorder in a Japanese population: a multicenter study. Biol Psychiatry, 2004; 56: 376-378.
    9. Koizumi H, Hashimoto K, Kumakiri C, Shimizu E, Sekine Y, Ozaki N, Inada T, Harano M, Komiyama T, Yamada M, Sora I, Ujike H, Takei N, Iyo M. Association between the glutathione S-transferase M1 gene deletion and female methamphetamine abusers. Am J Med Genet, 2004; 126B: 43-45.
    10. Kobayashi H, Ide S, Hasegawa J, Ujike H, Sekine Y, Ozaki N, Inada T, Harano M, Komiyama T, Yamada M, Iyo M, Shen HW, Ikeda K, Soraa I. Study of Association between {alpha}-Synuclein Gene Polymorphism and Methamphetamine Psychosis/Dependence. Ann N Y Acad Sci, 2004; 1025: 325-334.
    11. Iwata N, Suzuki T, Ikeda M, Kitajima T, Yamanouchi Y, Inada T, Ozaki N. No Association With the Neuregulin 1 Haplotype to Japanese Schizophrenia. Mol Psychiatry, 2004; 9: 126-127.
    12. Iwata N, Inada T, Harano M, Komiyama T, Yamada M, Sekine Y, Iyo M, Sora I, Ujike H, Ozaki N. No association is found between the candidate genes of t-PA/plasminogen system and Japanese methamphetamine-related disorder: a collaborative study by the Japanese Genetics Initiative for Drug Abuse. Ann N Y Acad Sci, 2004; 1025: 34-38.
    13. Itoh K, Hashimoto K, Shimizu E, Sekine Y, Ozaki N, Inada T, Harano M, Iwata N, Komiyama T, Yamada M, Sora I, Nakata K, Ujike H, Iyo M. Association study between brain-derived neurotrophic factor gene polymorphisms and methamphetamine abusers in Japan. Am J Med Genet B Neuropsychiatr Genet, 2004; 132B: 70-73.
    14. Inada T, Iijima Y, Uchida N, Maeda T, Iwashita S, Ozaki N, Harano M, Komiyama T, Yamada M, Sekine Y, Iyo M, Sora I, Ujikec H. No Association Found between the Type 1 Sigma Receptor Gene Polymorphisms and Methamphetamine Abuse in the Japanese Population: A Collaborative Study by the Japanese Genetics Initiative for Drug Abuse. Ann N Y Acad Sci, 2004; 1025: 27-33.
    15. Ikeda M, Iwata N, Suzuki T, Kitajima T, Yamanouchi Y, Kinoshita Y, Inada T, Ozaki N. Association of AKT1 with schizophrenia confirmed in a Japanese population. Biol Psychiatry, 2004; 56: 698-700.
    16. Ide S, Kobayashi H, Tanaka K, Ujike H, Sekine Y, Ozaki N, Inada T, Harano M, Komiyama T, Yamada M, Iyo M, Ikeda K, Sora I. Gene polymorphisms of the mu opioid receptor in methamphetamine abusers. Ann N Y Acad Sci, 2004; 1025: 316-324.
    17. Hashimoto R, Yoshida M, Ozaki N, Yamanouchi Y, Iwata N, Suzuki T, Kitajima T, Tatsumi M, Kamijima K, Kunugi H. Association analysis of the -308G>A promoter polymorphism of the tumor necrosis factor alpha (TNF-alpha) gene in Japanese patients with schizophrenia. J Neural Transm, 2004; 111: 217-221.
    18. Harano M, Uchimura N, Abe H, Ishibashi M, Iida N, Yanagimoto K, Tanaka T, Maeda H, Sora I, Iyo M, Komiyama T, Yamada M, Sekine Y, Inada T, Ozaki N, Ujike H. A Polymorphism of DRD2 Gene and Brain Atrophy in Methamphetamine Psychosis. Ann N Y Acad Sci, 2004; 1025: 307-315.
    19. Deng XX, Shibata HH, Ninomiya HH, Tashiro NN, Iwata NN, Ozaki NN, Fukumaki YY. Association study of polymorphisms in the excitatory amino acid transporter 2 gene (SLC1A2) with schizophrenia. BMC Psychiatry, 2004; 4: 21.
  • 2003年
    1. Yamanouchi Y, Iwata N, Suzuki T, Kitajima T, Ikeda M, Ozaki N. Effect of DRD2, 5-HT2A, and COMT genes on antipsychotic response to risperidone. Pharmacogenomics J, 2003; 3: 356-361.
    2. Ujike H, Harano M, Inada T, Yamada M, Komiyama T, Sekine Y, Sora I, Iyo M, Katsu T, Nomura A, Nakata K, Ozaki N. Nine- or fewer repeat alleles in VNTR polymorphism of the dopamine transporter gene is a strong risk factor for prolonged methamphetamine psychosis. Pharmacogenomics J, 2003; 3: 242-247.
    3. Tokura T, Murase T, Toriyama T, Totani Y, Negita M, Akaza K, Ozawa H, Nakagawa A, Nakamura S. Asian variant of CD5+ intravascular large B-cell lymphoma with splenic infarction. Intern Med, 2003; 42: 105-109.
    4. Suzuki T, Iwata N, Kitamura Y, Kitajima T, Yamanouchi Y, Ikeda M, Nishiyama T, Kamatani N, Ozaki N. Association of a haplotype in the serotonin 5-HT4 receptor gene (HTR4) with Japanese schizophrenia. Am J Med Genet B Neuropsychiatr Genet, 2003; 121: 7-13.
    5. Ozaki N, Goldman D, Kaye WH, Plotnicov K, Greenberg BD, Lappalainen J, Rudnick G, Murphy DL. Serotonin transporter missense mutation associated with a complex neuropsychiatric phenotype. Mol Psychiatry, 2003; 8: 933-936.
    6. Ozaki N. Psychopharmacogenetics. In: Encyclopedia of Human Genome, edited by DN Cooper. pp. 917-922, 2003, Nature Publishing Group, London, New York and Tokyo.
    7. Okada T, Toichi M, Sakihama M. Influences of an anticholinergic antiparkinsonian drug, parkinsonism, and psychotic symptoms on cardiac autonomic function in schizophrenia. J Clin Psychopharmacol, 2003; 23: 441-447.
    8. Okada M, Irie S, Sawada M, Urae R, Urae A, Iwata N, Ozaki N, Akazawa K, Nakanishi H. Pepstatin A induces extracellular acidification distinct from aspartic protease inhibition in microglial cell lines. Glia, 2003; 43: 167-174.
    9. Noda M, Yasuda S, Okada M, Higashida H, Shimada A, Iwata N, Ozaki N, Nishikawa K, Shirasawa S, Uchida M, Aoki S, Wada K. Recombinant human serotonin 5A receptors stably expressed in C6 glioma cells couple to multiple signal transduction pathways. J Neurochem, 2003; 84: 222-232.
    10. Kusunoki K, Kitajima T, Ozaki N. Does quazepam influence sleep and daytime activity in healthy adults? Sleep and Biological Rhythms, 2003; 1: 171-172.
    11. Kubota Y, Querel C, Pelion F, Laborit J, Laborit MF, Gorog F, Okada T, Murai T, Sato W, Yoshikawa S, Toichi M, Hayashi T. Facial affect recognition in pre-lingually deaf people with schizophrenia. Schizophr Res, 2003; 61: 265-270.
  • 2002年
    1. Toichi M, Kamio Y, Okada T, Sakihama M, Youngstrom EA, Findling RL, Yamamoto K. A lack of self-consciousness in autism. Am J Psychiatry, 2002; 159: 1422-1424.
    2. Sato W, Kubota Y, Okada T, Murai T, Yoshikawa S, Sengoku A. Seeing happy emotion in fearful and angry faces: qualitative analysis of facial expression recognition in a bilateral amygdala-damaged patient. Cortex, 2002; 38: 727-742.
    3. Iwase T, Kajimura N, Uchiyama M, Ebisawa T, Yoshimura K, Kamei Y, Shibui K, Kim K, Kudo Y, Katoh M, Watanabe T, Nakajima T, Ozeki Y, Sugishita M, Hori T, Ikeda M, Toyoshima R, Inoue Y, Yamada N, Mishima K, Nomura M, Ozaki N, Okawa M, Takahashi K, Yamauchi T. Mutation screening of the human Clock gene in circadian rhythm sleep disorders. Psychiatry Res, 2002; 109: 121-128.
    4. Hirano S, Sato T, Narita T, Kusunoki K, Ozaki N, Kimura S, Takahashi T, Sakado K, Uehara T. Evaluating the state dependency of the Temperament and Character Inventory dimensions in patients with major depression: a methodological contribution. J Affect Disord, 2002; 69: 31-38.
  • 2001年
    1. Kubota Y, Sato W, Toichi M, Murai T, Okada T, Hayashi A, Sengoku A. Frontal midline theta rhythm is correlated with cardiac autonomic activities during the performance of an attention demanding meditation procedure. Brain Res Cogn Brain Res, 2001; 11: 281-287.
    2. Kubota Y, Murai T, Okada T, Hayashi A, Toichi M, Sakihama M, Sakamoto T, Asanuma K, Matsumoto S, Kaji R. Obsessive-compulsive characteristics in patients with writer's cramp. J Neurol Neurosurg Psychiatry, 2001; 71: 413-414.
    3. Iwata N, Ozaki N, Inada T, Goldman D. Association of a 5-HT(5A) receptor polymorphism, Pro15Ser, to schizophrenia. Mol Psychiatry, 2001; 6: 217-219.
    4. Imamura K, Sawada M, Ozaki N, Naito H, Iwata N, Ishihara R, Takeuchi T, Shibayama H. Activation mechanism of brain microglia in patients with diffuse neurofibrillary tangles with calcification: a comparison with Alzheimer disease. Alzheimer Dis Assoc Disord, 2001; 15: 45-50.
    5. Hatsuda S, Sugita S, Suzuki S, Matsubara M, Ozaki N, Kayukawa Y, Ohara M. Inhibition of K(+)-evoked release of rat striatal 5-hydroxytryptamine by an atypical antidepressant: trazodone. Neuropsychobiology, 2001; 44: 103-107.
    6. Ebisawa T, Uchiyama M, Kajimura N, Mishima K, Kamei Y, Katoh M, Watanabe T, Sekimoto M, Shibui K, Kim K, Kudo Y, Ozeki Y, Sugishita M, Toyoshima R, Inoue Y, Yamada N, Nagase T, Ozaki N, Ohara O, Ishida N, Okawa M, Takahashi K, Yamauchi T. Association of structural polymorphisms in the human period3 gene with delayed sleep phase syndrome. EMBO Rep, 2001; 2: 342-346.
  • 2000年
    1. Kusunoki K, Sato T, Taga C, Yoshida T, Komori K, Narita T, Hirano S, Iwata N, Ozaki N. Low novelty-seeking differentiates obsessive-compulsive disorder from major depression. Acta Psychiatr Scand, 2000; 101: 403-405.
    2. Kayukawa Y, Shirakawa S, Hayakawa T, Imai M, Iwata N, Ozaki N, Ohta T. Habitual snoring in an outpatient population in Japan [In Process Citation]. Psychiatry Clin Neurosci, 2000; 54: 385-391.
    3. Hibiya M, Ichinose H, Ozaki N, Fujita K, Nishimoto T, Yoshikawa T, Asano Y, Nagatsu T. Normal values and age-dependent changes in GTP cyclohydrolase I activity in stimulated mononuclear blood cells measured by high-performance liquid chromatography. J Chromatogr B Biomed Sci Appl, 2000; 740: 35-42.
  • 1999年
    1. Sher L, Goldman D, Ozaki N, Rosenthal NE. The role of genetic factors in the etiology of seasonal affective disorder and seasonality. J Affect Disord, 1999; 53: 203-210.
    2. Lappalainen J, Long JC, Virkkunen M, Ozaki N, Goldman D, Linnoila M. HTR2C Cys23Ser polymorphism in relation to CSF monoamine metabolite concentrations and DSM-III-R psychiatric diagnoses. Biol Psychiatry, 1999; 46: 821-826.
    3. Kusunoki K, Ozaki N, Sawada M, Sato T, Hirano S, Narita T. Serum levels of dihydroneopterin and soluble cytokine receptors in major depression. Pteridines, 1999; 10: 24-26.
  • 1998年
    1. Rosenthal NE, Mazzanti CM, Barnett RL, Hardin TA, Turner EH, Lam GK, Ozaki N, Goldman D. Role of serotonin transporter promoter repeat length polymorphism (5-HTTLPR) in seasonality and seasonal affective disorder. Mol Psychiatry, 1998; 3: 175-177.
    2. Lappalainen J, Long JC, Eggert M, Ozaki N, Robin RW, Brown GL, Naukkarinen H, Virkkunen M, Linnoila M, Goldman D. Linkage of antisocial alcoholism to the serotonin 5-HT1B receptor gene in 2 populations. Arch Gen Psychiatry, 1998; 55: 989-994.
    3. Komori K, Nakamura M, Hatashita T, Shibazaki I, Fujita K, Naitoh H, Ozaki N, Yamawaki Y, Nagatsu I, Karasawa N. Studies on the effect of L-threo-DOPS as a catecholamine precursor in the mouse brain. Neuroscience Research, 1998; Supplement22: S93.
  • 1997年
    1. Schwartz PJ, Murphy DL, Wehr TA, Garcia-Borreguero D, Oren DA, Moul DE, Ozaki N, Snelbaker AJ, Rosenthal NE. Effects of meta-chlorophenylpiperazine infusions in patients with seasonal affective disorder and healthy control subjects. Diurnal responses and nocturnal regulatory mechanisms. Arch Gen Psychiatry, 1997; 54: 375-385.
    2. Sato T, Uehara T, Sakado K, Nishioka K, Ozaki N, Nakamura M, Kasahara Y. Dysfunctional parenting and a lifetime history of depression in a volunteer sample of Japanese workers. Acta Psychiatr Scand, 1997; 96: 306-310.
    3. Ozaki N, Manji H, Lubierman V, Lu SJ, Lappalainen J, Rosenthal NE, Goldman D. A naturally occurring amino acid substitution of the human serotonin 5-HT2A receptor influences amplitude and timing of intracellular calcium mobilization. J Neurochem, 1997; 68: 2186-2193.
  • 1996年
    1. Ozaki N, Rosenthal NE, Pesonen U, Lappalainen J, Feldman-Naim S, Schwartz PJ, Turner EH, Goldman D. Two naturally occurring amino acid substitutions of the 5-HT2A receptor: similar prevalence in patients with seasonal affective disorder and controls. Biol Psychiatry, 1996; 40: 1267-1272.
    2. Malhotra AK, Goldman D, Ozaki N, Rooney W, Clifton A, Buchanan RW, Breier A, Pickar D. Clozapine response and the 5HT2C Cys23Ser polymorphism. Neuroreport, 1996; 7: 2100-2102.
    3. Malhotra AK, Goldman D, Ozaki N, Breier A, Buchanan R, Pickar D. Lack of association between polymorphisms in the 5-HT2A receptor gene and the antipsychotic response to clozapine. Am J Psychiatry, 1996; 153: 1092-1094.
    4. Goldman D, Lappalainen J, Ozaki N. Direct analysis of candidate genes in impulsive behaviours. Ciba Found Symp, 1996; 194: 139-152; discussion 152-134.
  • 1995年
    1. Ozaki N, Rosenthal NE, Myers F, Schwartz PJ, Oren DA. Effects of season on electro-oculographic ratio in winter seasonal affective disorder. Psychiatry Res, 1995; 59: 151-155.
    2. Ozaki N, Ono Y, Ito A, Rosenthal NE. Prevalence of seasonal difficulties in mood and behavior among Japanese civil servants. Am J Psychiatry, 1995; 152: 1225-1227.
    3. Ozaki N, Lappalainen J, Dean M, Virkkunen M, Linnoila M, Goldman D. Mapping of the serotonin 5-HT1D alpha autoreceptor gene (HTR1D) on chromosome 1 using a silent polymorphism in the coding region. Am J Med Genet, 1995; 60: 162-164.
    4. Lappalainen J, Zhang L, Dean M, Oz M, Ozaki N, Yu DH, Virkkunen M, Weight F, Linnoila M, Goldman D. Identification, expression, and pharmacology of a Cys23-Ser23 substitution in the human 5-HT2c receptor gene (HTR2C). Genomics, 1995; 27: 274-279.
  • 1994年
    1. Ozaki N, Rosenthal NE, Mazzola P, Chiueh CC, Hardin T, Garcia-Borreguero D, Schwartz PJ, Turner E, Oren DA, Murphy DL. Platelet [3H]paroxetine binding, 5-HT-stimulated Ca2+ response, and 5-HT content in winter seasonal affective disorder. Biol Psychiatry, 1994; 36: 458-466.
  • 1993年
    1. Ozaki N, Rosenthal NE, Moul DE, Schwartz PJ, Oren DA. Effects of phototherapy on electrooculographic ratio in winter seasonal affective disorder. Psychiatry Res, 1993; 49: 99-107.
    2. Ozaki N, Duncan WC, Jr., Johnson KA, Wehr TA. Diurnal variations of serotonin and dopamine levels in discrete brain regions of Syrian hamsters and their modification by chronic clorgyline treatment. Brain Res, 1993; 627: 41-48.
  • 1992年
    1. Nakahara D, Fuchikami K, Ozaki N, Iwasaki T, Nagatsu T. Differential effect of self-stimulation on dopamine release and metabolism in the rat medial frontal cortex, nucleus accumbens and striatum studied by in vivo microdialysis. Brain Research, 1992; 574: 164-170.
    2. Ito A, Ichihara M, Hisanaga N, Ono Y, Kayukawa Y, Ohta T, Okada T, Ozaki N. Prevalence of seasonal mood changes in low latitude area: Seasonal Pattern Assessment Questionnaire score of Quezon City workers. Jpn J Psychiatry Neurol, 1992; 46: 249.
  • 1991年
    1. Ozaki N, Nakahara D, Kasahara Y, Nagatsu T. The effect of methamphetamine on serotonin and its metabolite in the suprachiasmatic nucleus: a microdialysis study. J Neural Transm Gen Sect, 1991; 86: 175-179.
    2. Ohta T, Ando K, Iwata T, Ozaki N, Kayukawa Y, Terashima M, Okada T, Kasahara Y. Treatment of persistent sleep-wake schedule disorders in adolescents with methylcobalamin (vitamin B12). Sleep, 1991; 14: 414-418.
  • 1990年
    1. Hashimoto R, Ozaki N, Ohta T, Kasahara Y, Kaneda N, Nagatsu T. The plasma tetrahydrobiopterin levels in patients with affective disorders. Biol Psychiatry, 1990; 28: 526-528.
    2. Hashimoto R, Ozaki N, Ohta T, Kasahara Y, Kaneda N, Nagatsu T. Plasma tetrahydrobiopterin levels in patients with psychiatric disorders. Neuropsychobiology, 1990; 23: 140-143.
  • 1989年
    1. Unkrig V, Neugebauer FA, Knappe J. The free radical of pyruvate formate-lyase. Characterization by EPR spectroscopy and involvement in catalysis as studied with the substrate-analogue hypophosphite. Eur J Biochem, 1989; 184: 723-728.
    2. Ozaki N, Nakahara D, Miura H, Kasahara Y, Nagatsu T. Effects of apomorphine on in vivo release of dopamine and its metabolites in the prefrontal cortex and the striatum, studied by a microdialysis method. J Neurochem, 1989; 53: 1861-1864.
    3. Ozaki N, Iwata T, Itoh A, Ohta T, Okada T, Kasahara Y. A treatment trial of delayed sleep phase syndrome with triazolam. Jpn J Psychiatry Neurol, 1989; 43: 51-55.
    4. Nakahara D, Ozaki N, Nagatsu T. A removable microdialysis probe unit for in vivo studies of neurochemical acitvity. Biogenic amines, 1989; 6: 559-564.
    5. Nakahara D, Ozaki N, Miura Y, Miura H, Nagatsu T. Increased dopamine and serotonin metabolism in rat nucleus accumbens produced by intracranial self-stimulation of medial forebrain bundle as measured by in vivo microdialysis. Brain Res, 1989; 495: 178-181.
    6. Nakahara D, Ozaki N, Kapoor V, Nagatsu T. The effect of uptake inhibition on dopamine release from the nucleus accumbens of rats during self- or forced stimulation of the medial forebrain bundle: a microdialysis study. Neurosci Lett, 1989; 104: 136-140.
  • 1988年
    1. Ozaki N, Nakahara D, Mogi M, Harada M, Kiuchi K, Kaneda N, Miura Y, Kasahara Y, Nagatsu T. Inactivation of tyrosine hydroxylase in rat striatum by 1-methyl-4-phenylpyridinium ion (MPP+). Neurosci Lett, 1988; 85: 228-232.
    2. Ozaki N, Iwata T, Itoh A, Kogawa S, Ohta T, Okada T, Kasahara Y. Body temperature monitoring in subjects with delayed sleep phase syndrome. Neuropsychobiology, 1988; 20: 174-177.
    3. Nakahara D, Ozaki N, Kaneda N, Kiuchi K, Okada T, Ohta T, Nagatsu T. Intracerebrally administered (6r)-l-erythro-tetrahydrobiopterin does not affect extracellular levels of dopamine and serotonin metabolites in rat striatum in vivo during measurement by brain micro-dialysis system. Neurochem Int, 1988; 12: 121-124.
    4. Ichinose H, Ozaki N, Nakahara D, Naoi M, Wakabayashi K, Sugimura T, Nagatsu T. Effects of heterocyclic amines in food on dopamine metabolism in nigro-striatal dopaminergic neurons. Biochem Pharmacol, 1988; 37: 3289-3295.
    5. Hashimoto R, Ozaki N, Ohta T, Kasahara Y, Kaneda N, Nagatsu T. Plasma biopterin levels of patients with affective disorders. Neuropsychobiology, 1988; 19: 61-63.
    6. Alexander N, Nakahara D, Ozaki N, Kaneda N, Sasaoka T, Iwata N, Nagatsu T. Striatal dopamine release and metabolism in sinoaortic-denervated rats by in vivo microdialysis. Am J Physiol, 1988; 254: R396-399.
  • 1987年
    1. Ozaki N, Nakahara D, Kaneda N, Kiuchi K, Okada T, Kasahara Y, Nagatsu T. Acute effects of 1-methyl-4-phenylpyridinium ion (MPP+) on dopamine and serotonin metabolism in rat striatum as assayed in vivo by a micro-dialysis technique. J Neural Transm, 1987; 70: 241-250.
    2. Hashimoto R, Ozaki N, Ohta T, Kasahara Y, Kaneda N, Nagatsu T. Total biopterin levels of plasma in patients with depression. Neuropsychobiology, 1987; 17: 176-177.
  • 1986年
    1. Ozaki N, Okada T, Iwata T, Ohta T, Kasahara Y, Kiuchi K, Nagatsu T. Plasma norepinephrine in sleep apnea syndrome. Neuropsychobiology, 1986; 16: 88-92.

研究キーワード

精神医学、児童思春期精神医学、精神障害、統合失調症、うつ病、双極性障害、認知症、摂食障害、自閉スペクトラム症、不安症、身体症状症、周産期、産業衛生医学、歯科口腔外科学、がん、臓器移植、心不全、オミックス、ゲノム、遺伝子改変、モデル動物、iPS細胞、神経画像、MRI、NIRS、死後脳、疼痛、自動車運転技能、向精神薬、高齢者、神経性やせ症、妊産婦、ゲノムコホート、エピゲノム

大学院の概要;研究と教育の基本方針

患者・家族のニーズを踏まえ、「日々の臨床疑問の解決」とともに、「病因・病態を解明し、病因・病態に即した診断、治療・予防法の開発」を目指すことが研究の基本方針です。

summary1.jpg

この目的の実現には、様々な臨床研究、基礎研究が双方向性に共同することが不可欠です。以上を踏まえ、大学院教育においては、多様な志向性を持ち、多面的な観点から研究を行い、臨床と基礎研究の共同を実現させる人材を育成することを目指しております。

summary2.jpg

具体的には、文献の検索と批判的吟味、研究デザイン、実験ノートの書き方、データ解析、データプレゼンテーション、サイエンティフィックライティングといった研究遂行に必要な基本的ノウハウを身につけ、今後の研究活動の基礎だけではなく、臨床にも活かせる科学的視点を身につけることができるよう指導しています。

  1. "精神医学"、"精神生物学"、"発達・老年精神医学"、"親と子どもの心療学"の各分野に所属しますが、加えて「精神医療学寄附講座」「障害児(者)寄附講座」「睡眠学寄附講座」「脳とこころの研究センター」等とも連動して全体で"精神科ユニット"を構成し、共同指導体制をとっています。
  2. 医学部卒業生のみならず、医学部以外の心理学関連専攻の学科、薬学部、保健学部などを卒業した方も歓迎しています。
  3. 医学部卒業生と修士課程卒業生対象の博士課程に加えて、医学部以外の卒業生対象の修士課程を募集しています。
  4. 研究に専念する一般の博士課程大学院生となる選択肢と、基幹施設或いは連携施設で精神科医としての勤務を続けながら社会人大学院生となる選択肢があります。
  5. 医師の場合、所属医局は問いません。ただし少なくとも一年以上の精神科臨床経験を経て、精神障害の実際をある程度知った後、入学していただくのを原則としています。精神科・児童精神科の専門研修プログラム中の医師は、以下の3つのコースから選ぶことが可能です。
    (ア) 一般の大学院生を選び、研修プログラム履修を休止して、大学院修了後、研修を再開する。
    (イ) 一般の大学院生を選び、基幹施設で診療従事届けを提出し、連携施設での研修状況も勘案して、研修期間に一部カウントする。
    (ウ) 社会人大学院生を選び、研修をそのまま継続する。
  6. どのコースを選ぶかは、ご本人の希望を重視して相談に応じます。
  7. 大学院生期間中の研究時間の確保:大学院生には基本的に診療上の義務は課していません。各個人の希望でスケジュールを組んでいるので、十分研究時間は確保されています。社会人大学院生として、大学外の施設に所属しながら入学する場合も、できるだけ研究時間を確保するよう各施設の配慮をお願いしています。