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病理病態学生体反応病理学/分子病理診断学(病理学第一)

研究室概要

酸化ストレスの生物学的意義を細胞からヒト個体レベルまで広くかつ深く追究しています。病理学固有の形態学を重視しながら、遺伝学的・細胞工学的・遺伝子工学的な手法を駆使して以下のテーマに取り組んでいます。出身分野にかかわらず、酸化ストレスに深い興味を持つ学生が研究室に参加することを望みます。当講座では、遺伝子改変動物の解析に必須の形態学的な知識を広く身につけることが出来ます。MDのひとは、希望により病理医としての基礎的な研修を併行して行うことができます(名古屋大学医学部附属病院としての病理専門医研修プラグラムに組み込まれています)。関連病院での非常勤勤務も可能です。教室を主宰する豊國伸哉は日本酸化ストレス学会ならびに日本鉄バイオサイエンス学会の理事長であり、国際的にはSociety for Free Radical Research InternationalのPresidentです。

研究プロジェクト

1.活性酸素による発がんメカニズムの解析

25年に渡り当研究室で解析されてきた鉄ニトリロ三酢酸による腎発がんモデルの解析もいよいよ佳境に入ってきています。2002年2月にはAm J Pathol誌に、主な標的遺伝子のひとつであるp16のallelic lossが投与開始後数週のたいへん早い時期に起こっていることをCommentary付きで発表しました。いよいよヒト発がんへの応用、全ゲノム的な解析を開始しています。また、最近ではオキシゲノミクス(Oxygenomics)というコンセプトを提唱し、ゲノム内で酸化的傷害の起こりやすい部位を網羅的に解析することに取り組んでいます。オキシゲノミクスを総説で解説しています(Toyokuni S and Akatsuka S, J Clin Biochem Nutr 39: 3-10, 2006)。2006年秋にはオキシゲノミクスの方法論に関する論文を発表しました。このモデルのCGH解析により、酸化ストレスによりwild-type動物に発生したがんではそのゲノムの変化がヒトのがんに極めて類似することが判明しました(Akatsuka et al. PLoS ONE 2012)。これは、ヒトのがんの根本原因も酸化ストレスにあることを示唆しています。がんからゲノムの酸化的な傷害へ仕事は大きく進展しています。また、このモデルを使用したがん予防法の検討にも取り組んでいます。

project1.jpg

2.繊維状無機物質の毒性・発がん性の研究

project2.jpg平成18年度よりラボをあげて、アスベスト病態の解明に取り組んでいます。鉄含有率の高いアスベスト繊維ほど、発がん性の高いことが疫学的に明らかにされていますが、わたしたちの研究により鉄を含んでいない白石綿(クリソタイル)も体内で鉄を集めることにより、極めて発がん性が高いことが明らかとなっています(Jiang et al. J Pathol 2012)。鉄発がんの研究からこれまでに蓄積してきたノウハウを結集して、サイエンスから社会への還元を目指して取り組んでおり、除鉄に予防効果のあることがわかりつつあり(Nagai et al. Cancer Prev Res 2013)、新規治療薬の開発にも取り組んでいます。また、最近では、新規素材として期待されているカーボンナノチューブの毒性・発がん性評価にも社会からの要請から取り組んでいます。その結果、50 nm程度の太さの多層カーボンナノチューブにはアスベストと同様の中皮腫発がん性があることが判明し、この種の素材は注意して扱うべき事を警告しました(Nagai et al. Proc Natl Acad Sci USA 2011)。この結果はIARCにより50 nmカーボンナノチューブのGroup 2Bの根拠にも使用されています。現在のところ、固形物内で使用されており、アスベストと違い、一般消費者に害が及ぶ可能性は少ないと考えています。現在、この発がんメカニズムについても詳細に検討中です。

3.酸化ストレスマーカーの開発、酸化的組織細胞傷害の可視化に関する研究

project3.jpg上記1および2より得られた成果をもとに、新たな酸化ストレスマーカーの開発を行っています。酸化ストレスは,発がんのみならず動脈硬化症・糖尿病などのさまざまな生活習慣病の病態に関わっていることがわかってきており、そのモニタリングは今後ますます重要になると考えられます。最近では、フェントン反応の基点となる触媒性二価鉄を可視化する方法を共同研究として開発しています(Mukaide et al. Free Radic Res 2014)。

4.低温プラズマの医療応用に関する研究

project4.jpg平成24年より医工連携としてこのプロジェクトに取り組んでいます。プラズマとは固体・液体・気体に次ぐ第4の物理的状態で、気体・電子・ラジカル・イオン・紫外線などを混じた状態です。太陽や雷が自然界に存在するプラズマですがいずれも高温です。ところが、90年代から体温に近い低温プラズマの作成が可能となりました。この医療応用をめざしています。これまでの研究により、低温プラズマにより種々の程度の酸化ストレスを意図的に与えることができることが明らかになってきており(Okazaki et al. J Clin Biochem Nutr 2014)、今後、殺菌・止血やがん治療など幅広い応用が可能であると考えられます。

5.病理診断マーカーに関する研究

日常の病理診断からヒントを得た鑑別診断の問題に取り組んでいます。最近は、山下享子助教の着任により特に軟部腫瘍の研究を推進しています。

教員

構成員名役職所属
豊國 伸哉 教授 生体反応病理学
岡﨑 泰昌 講師 生体反応病理学
山下 享子 助教 生体反応病理学
赤塚 慎也 講師 分子病理診断学

研究実績

  • 2016年
    1. Wang Y, Okazaki Y, Shi L, Kohda H, Tanaka M, Taki K, Nishioka T, Hirayama T, Nagasawa H, Yamashita Y, Toyokuni S. Role of hemoglobin and transferrin in multi-wall carbon nanotube-induced mesothelial injury and carcinogenesis. Cancer Sci. 2016; 107: 250-7.
    2. Wang S, Jiang L, Han Y, Hwu Chew S, Ohara Y, Akatsuka S, Weng L, Kawaguchi K, Fukui T, Sekido Y, Yokoi K, Toyokuni S. Urokinase-type plasminogen activator receptor promotes proliferation and invasion with reduced cisplatin sensitivity in malignant mesothelioma. Oncotarget. 2016.
    3. Utsumi F, Kajiyama H, Nakamura K, Tanaka H, Mizuno M, Toyokuni S, Hori M, Kikkawa F. Variable susceptibility of ovarian cancer cells to non-thermal plasma-activated medium. Oncol Rep. 2016; 35: 3169-77.
    4. Tsuzuki Y, Yamashita Y, Hattori Y, Hua Li G, Akatsuka S, Kotani T, Kikkawa F, Naiki-Ito A, Takahashi S, Nishiwaki K, Toyokuni S. Pain-reducing anesthesia prevents oxidative stress in human term placenta. J Clin Biochem Nutr. 2016; 58: 156-60.
    5. Toyokuni S. The origin and future of oxidative stress pathology: From the recognition of carcinogenesis as an iron addiction with ferroptosis-resistance to non-thermal plasma therapy. Pathol Int. 2016; 66: 245-59.
    6. Toyokuni S. Oxidative stress as an iceberg in carcinogenesis and cancer biology. Arch Biochem Biophys. 2016; 595: 46-9.
    7. Shi L, Wang Y, Ito F, Okazaki Y, Tanaka H, Mizuno M, Hori M, Richardson DR, Toyokuni S. Biphasic effects of l-ascorbate on the tumoricidal activity of non-thermal plasma against malignant mesothelioma cells. Arch Biochem Biophys. 2016; 605: 109-16.
    8. Lin Y, Ohkawara B, Ito M, Misawa N, Miyamoto K, Takegami Y, Masuda A, Toyokuni S, Ohno K. Molecular hydrogen suppresses activated Wnt/beta-catenin signaling. Sci Rep. 2016; 6: 31986.
    9. Kambe T, Fukada T, Toyokuni S. Editorial: The cutting edge of zinc biology. Arch Biochem Biophys. 2016.
    10. Kalinowski DS, Stefani C, Toyokuni S, Ganz T, Anderson GJ, Subramaniam NV, Trinder D, Olynyk JK, Chua A, Jansson PJ, Sahni S, Lane DJ, Merlot AM, Kovacevic Z, Huang ML, Lee CS, Richardson DR. Redox cycling metals: Pedaling their roles in metabolism and their use in the development of novel therapeutics. Biochim Biophys Acta. 2016; 1863: 727-48.
    11. Jiang L, Chew SH, Nakamura K, Ohara Y, Akatsuka S, Toyokuni S. Dual preventive benefits of iron elimination by desferal in asbestos-induced mesothelial carcinogenesis. Cancer Sci. 2016; 107: 908-15.
    12. Ito F, Nishiyama T, Shi L, Mori M, Hirayama T, Nagasawa H, Yasui H, Toyokuni S. Contrasting intra- and extracellular distribution of catalytic ferrous iron in ovalbumin-induced peritonitis. Biochem Biophys Res Commun. 2016; 476: 600-6.
    13. Ishida C, Mori M, Nakamura K, Tanaka H, Mizuno M, Hori M, Iwase A, Kikkawa F, Toyokuni S. Non-thermal plasma prevents progression of endometriosis in mice. Free Radic Res. 2016: 1-9.
    14. Imai K, Kotani T, Tsuda H, Mano Y, Nakano T, Ushida T, Li H, Miki R, Sumigama S, Iwase A, Hirakawa A, Ohno K, Toyokuni S, Takeuchi H, Mizuno T, Suzumura A, Kikkawa F. Neuroprotective potential of molecular hydrogen against perinatal brain injury via suppression of activated microglia. Free Radic Biol Med. 2016; 91: 154-63.
    15. Hori M, Choi EH, Toyokuni S. Low-temperature plasma in biology and medicine. Arch Biochem Biophys. 2016; 605: 1-2.
    16. Hirako S, Tsuda H, Kotani T, Sumigama S, Mano Y, Nakano T, Imai K, Li H, Toyokuni S, Kikkawa F. Antenatal Saireito (TJ-114) Can Improve Pulmonary Hypoplasia and Pulmonary Vascular Remodeling in Nitrofen-Induced Congenital Diaphragmatic Hernia. Phytother Res. 2016; 30: 1474-80.
    17. Forman HJ, Toyokuni S. Tribute issue: Helmut Sies and oxidative stress: Venit, vidit, vicit. Arch Biochem Biophys. 2016; 595: 2.
    18. Cahill MA, Jazayeri JA, Catalano SM, Toyokuni S, Kovacevic Z, Richardson DR. The emerging role of progesterone receptor membrane component 1 (PGRMC1) in cancer biology. Biochim Biophys Acta. 2016.
  • 2015年
    1. Yamashita Y, Nagasaka T, Naiki-Ito A, Sato S, Suzuki S, Toyokuni S, Ito M, Takahashi S. Napsin A is a specific marker for ovarian clear cell adenocarcinoma. Mod Pathol. 2015; 28: 111-7.
    2. Yamashita K, Nagai H, Toyokuni S. Receptor role of the annexin A2 in the mesothelial endocytosis of crocidolite fibers. Lab Invest. 2015; 95: 749-64.
    3. Toyokuni S, Jiang LI, Kitaura R, Shinohara H. Minimal inflammogenicity of pristine single-wall carbon nanotubes. Nagoya J Med Sci. 2015; 77: 195-202.
    4. Toyokuni S, Jiang L, Wang S, Hirao A, Wada T, Soh C, Toyama K, Kawada A. Aging rather than sun exposure is a major determining factor for the density of miR-125b-positive epidermal stem cells in human skin. Pathol Int. 2015; 65: 415-9.
    5. Nakano T, Kotani T, Mano Y, Tsuda H, Imai K, Ushida T, Li H, Miki R, Sumigama S, Sato Y, Iwase A, Hirakawa A, Asai M, Toyokuni S, Kikkawa F. Maternal molecular hydrogen administration on lipopolysaccharide-induced mouse fetal brain injury. J Clin Biochem Nutr. 2015; 57: 178-82.
    6. Mori M, Ito F, Shi L, Wang Y, Ishida C, Hattori Y, Niwa M, Hirayama T, Nagasawa H, Iwase A, Kikkawa F, Toyokuni S. Ovarian endometriosis-associated stromal cells reveal persistently high affinity for iron. Redox Biol. 2015; 6: 578-86.
    7. Hattori Y, Mukaide T, Jiang L, Kotani T, Tsuda H, Mano Y, Sumigama S, Hirayama T, Nagasawa H, Kikkawa F, Toyokuni S. Catalytic ferrous iron in amniotic fluid as a predictive marker of human maternal-fetal disorders. J Clin Biochem Nutr. 2015; 56: 57-63.
    8. Hattori Y, Kotani T, Tsuda H, Mano Y, Tu L, Li H, Hirako S, Ushida T, Imai K, Nakano T, Sato Y, Miki R, Sumigama S, Iwase A, Toyokuni S, Kikkawa F. Maternal molecular hydrogen treatment attenuates lipopolysaccharide-induced rat fetal lung injury. Free Radic Res. 2015; 49: 1026-37.
    9. Funahashi S, Okazaki Y, Ito D, Asakawa A, Nagai H, Tajima M, Toyokuni S. Asbestos and multi-walled carbon nanotubes generate distinct oxidative responses in inflammatory cells. J Clin Biochem Nutr. 2015; 56: 111-7.
    10. Chew SH, Toyokuni S. Malignant mesothelioma as an oxidative stress-induced cancer: An update. Free Radic Biol Med. 2015; 86: 166-78.
    11. Asano T, Koike M, Sakata S, Takeda Y, Nakagawa T, Hatano T, Ohashi S, Funayama M, Yoshimi K, Asanuma M, Toyokuni S, Mochizuki H, Uchiyama Y, Hattori N, Iwai K. Possible involvement of iron-induced oxidative insults in neurodegeneration. Neurosci Lett. 2015; 588: 29-35.
  • 2014年
    1. Yoshihara M, Jiang L, Akatsuka S, Suyama M, Toyokuni S. Genome-wide profiling of 8-oxoguanine reveals its association with spatial positioning in nucleus. DNA Res. 2014; 21: 603-12.
    2. Yamashita Y, Ito Y, Isomura H, Takemura N, Okamoto A, Motomura K, Tsujiuchi T, Natsume A, Wakabayashi T, Toyokuni S, Tsurumi T. Lack of presence of the human cytomegalovirus in human glioblastoma. Mod Pathol. 2014; 27: 922-9.
    3. Toyokuni S. Iron overload as a major targetable pathogenesis of asbestos-induced mesothelial carcinogenesis. Redox Rep. 2014; 19: 1-7.
    4. Toyokuni S. Iron and thiols as two major players in carcinogenesis: friends or foes? Front Pharmacol. 2014; 5: 200.
    5. Shinjo K, Yamashita Y, Yamamoto E, Akatsuka S, Uno N, Kamiya A, Niimi K, Sakaguchi Y, Nagasaka T, Takahashi T, Shibata K, Kajiyama H, Kikkawa F, Toyokuni S. Expression of chromobox homolog 7 (CBX7) is associated with poor prognosis in ovarian clear cell adenocarcinoma via TRAIL-induced apoptotic pathway regulation. Int J Cancer. 2014; 135: 308-18.
    6. Okazaki Y, Wang Y, Tanaka H, Mizuno M, Nakamura K, Kajiyama H, Kano H, Uchida K, Kikkawa F, Hori M, Toyokuni S. Direct exposure of non-equilibrium atmospheric pressure plasma confers simultaneous oxidative and ultraviolet modifications in biomolecules. J Clin Biochem Nutr. 2014; 55: 207-15.
    7. Nishiwaki S, Nakayama T, Murata M, Nishida T, Terakura S, Saito S, Kato T, Mizuno H, Imahashi N, Seto A, Ozawa Y, Miyamura K, Ito M, Takeshita K, Kato H, Toyokuni S, Nagao K, Ueda R, Naoe T. Dexamethasone palmitate ameliorates macrophages-rich graft-versus-host disease by inhibiting macrophage functions. PLoS One. 2014; 9: e96252.
    8. Mukaide T, Hattori Y, Misawa N, Funahashi S, Jiang L, Hirayama T, Nagasawa H, Toyokuni S. Histological detection of catalytic ferrous iron with the selective turn-on fluorescent probe RhoNox-1 in a Fenton reaction-based rat renal carcinogenesis model. Free Radic Res. 2014; 48: 990-5.
    9. Mano Y, Kotani T, Ito M, Nagai T, Ichinohashi Y, Yamada K, Ohno K, Kikkawa F, Toyokuni S. Maternal molecular hydrogen administration ameliorates rat fetal hippocampal damage caused by in utero ischemia-reperfusion. Free Radic Biol Med. 2014; 69: 324-30.
    10. Jiang L, Yamashita Y, Chew SH, Akatsuka S, Ukai S, Wang S, Nagai H, Okazaki Y, Takahashi T, Toyokuni S. Connective tissue growth factor and beta-catenin constitute an autocrine loop for activation in rat sarcomatoid mesothelioma. J Pathol. 2014; 233: 402-14.
    11. Handa O, Naito Y, Toyokuni S. As a host society to SFRRI 2014 in Kyoto. J Clin Biochem Nutr. 2014; 54: 1.
    12. Fujii K, Yamashita Y, Yamamoto T, Takahashi K, Hashimoto K, Miyata T, Kawai K, Kikkawa F, Toyokuni S, Nagasaka T. Ovarian mucinous tumors arising from mature cystic teratomas--a molecular genetic approach for understanding the cellular origin. Hum Pathol. 2014; 45: 717-24.
    13. Chew SH, Okazaki Y, Nagai H, Misawa N, Akatsuka S, Yamashita K, Jiang L, Yamashita Y, Noguchi M, Hosoda K, Sekido Y, Takahashi T, Toyokuni S. Cancer-promoting role of adipocytes in asbestos-induced mesothelial carcinogenesis through dysregulated adipocytokine production. Carcinogenesis. 2014; 35: 164-72.
    14. Aierken D, Okazaki Y, Chew SH, Sakai A, Wang Y, Nagai H, Misawa N, Kohyama N, Toyokuni S. Rat model demonstrates a high risk of tremolite but a low risk of anthophyllite for mesothelial carcinogenesis. Nagoya J Med Sci. 2014; 76: 149-60.
  • 2013年
    1. Yamazaki K, Tanaka S, Sakata R, Miwa S, Oriyanhan W, Takaba K, Minakata K, Marui A, Ikeda T, Toyokuni S, Komeda M, Ueda K. Protective effect of cardioplegia with poly (ADP-ribose) polymerase-1 inhibitor against myocardial ischemia-reperfusion injury: in vitro study of isolated rat heart model. J Enzyme Inhib Med Chem. 2013; 28: 143-7.
    2. Yamashita Y, Akatsuka S, Shinjo K, Yatabe Y, Kobayashi H, Seko H, Kajiyama H, Kikkawa F, Takahashi T, Toyokuni S. Met is the most frequently amplified gene in endometriosis-associated ovarian clear cell adenocarcinoma and correlates with worsened prognosis. PLoS One. 2013; 8: e57724.
    3. Yamashita K, Nagai H, Kondo Y, Misawa N, Toyokuni S. Evaluation of two distinct methods to quantify the uptake of crocidolite fibers by mesothelial cells. J Clin Biochem Nutr. 2013; 53: 27-35.
    4. Toyokuni S. Genotoxicity and carcinogenicity risk of carbon nanotubes. Adv Drug Deliv Rev. 2013; 65: 2098-110.
    5. Okazaki Y, Nagai H, Chew SH, Li J, Funahashi S, Tsujimura T, Toyokuni S. CD146 and insulin-like growth factor 2 mRNA-binding protein 3 predict prognosis of asbestos-induced rat mesothelioma. Cancer Sci. 2013; 104: 989-95.
    6. Nagai H, Okazaki Y, Chew SH, Misawa N, Yasui H, Toyokuni S. Deferasirox induces mesenchymal-epithelial transition in crocidolite-induced mesothelial carcinogenesis in rats. Cancer Prev Res (Phila). 2013; 6: 1222-30.
    7. Nagai H, Okazaki Y, Chew SH, Misawa N, Miyata Y, Shinohara H, Toyokuni S. Intraperitoneal administration of tangled multiwalled carbon nanotubes of 15 nm in diameter does not induce mesothelial carcinogenesis in rats. Pathol Int. 2013; 63: 457-62.
    8. Nagai H, Chew SH, Okazaki Y, Funahashi S, Namba T, Kato T, Enomoto A, Jiang L, Akatsuka S, Toyokuni S. Metamorphosis of mesothelial cells with active horizontal motility in tissue culture. Sci Rep. 2013; 3: 1144.
    9. Hotta H, Hamamura K, Yamashita K, Shibuya H, Tokuda N, Hashimoto N, Furukawa K, Yamamoto N, Hattori H, Toyokuni S, Ueda M, Furukawa K. Lewis y antigen is expressed in oral squamous cell carcinoma cell lines and tissues, but disappears in the invasive regions leading to the enhanced malignant properties irrespective of sialyl-Lewis x. Glycoconj J. 2013; 30: 585-97.
    10. Hamakawa M, Ishida A, Tamakoshi K, Shimada H, Nakashima H, Noguchi T, Toyokuni S, Ishida K. Repeated short-term daily exercise ameliorates oxidative cerebral damage and the resultant motor dysfunction after transient ischemia in rats. J Clin Biochem Nutr. 2013; 53: 8-14.
    11. Chikazawa M, Otaki N, Shibata T, Miyashita H, Kawai Y, Maruyama S, Toyokuni S, Kitaura Y, Matsuda T, Uchida K. Multispecificity of immunoglobulin M antibodies raised against advanced glycation end products: involvement of electronegative potential of antigens. J Biol Chem. 2013; 288: 13204-14.
  • 2012年
    1. Okazaki Y, Kono I, Kuriki T, Funahashi S, Fushimi S, Iqbal M, Okada S, Toyokuni S. Bovine lactoferrin ameliorates ferric nitrilotriacetate-induced renal oxidative damage in rats. J Clin Biochem Nutr. 2012; 51: 84-90.
    2. Nagai H, Toyokuni S. Differences and similarities between carbon nanotubes and asbestos fibers during mesothelial carcinogenesis: shedding light on fiber entry mechanism. Cancer Sci. 2012; 103: 1378-90.
    3. Morimoto H, Lee J, Tanaka T, Ishii K, Toyokuni S, Kanatsu-Shinohara M, Shinohara T. In vitro transformation of mouse testis cells by oncogene transfection. Biol Reprod. 2012; 86: 148, 1-11.
    4. Mizuno T, Murakami H, Fujii M, Ishiguro F, Tanaka I, Kondo Y, Akatsuka S, Toyokuni S, Yokoi K, Osada H, Sekido Y. YAP induces malignant mesothelioma cell proliferation by upregulating transcription of cell cycle-promoting genes. Oncogene. 2012; 31: 5117-22.
    5. Majima HJ, Toyokuni S. Mitochondria and free radical studies on health, disease and pollution. Free Radic Res. 2012; 46: 925-6.
    6. Kubo Y, Takenaka H, Nagai H, Toyokuni S. Distinct affinity of nuclear proteins to the surface of chrysotile and crocidolite. J Clin Biochem Nutr. 2012; 51: 221-6.
    7. Kobayashi H, Yamashita Y, Iwase A, Yoshikawa Y, Yasui H, Kawai Y, Uchida K, Uno N, Akatsuka S, Takahashi T, Kikkawa F, Toyokuni S. The ferroimmunomodulatory role of ectopic endometriotic stromal cells in ovarian endometriosis. Fertil Steril. 2012; 98: 415-22 e1-12.
    8. Jiang L, Akatsuka S, Nagai H, Chew SH, Ohara H, Okazaki Y, Yamashita Y, Yoshikawa Y, Yasui H, Ikuta K, Sasaki K, Kohgo Y, Hirano S, Shinohara Y, Kohyama N, Takahashi T, Toyokuni S. Iron overload signature in chrysotile-induced malignant mesothelioma. J Pathol. 2012; 228: 366-77.
    9. Ishii K, Kanatsu-Shinohara M, Toyokuni S, Shinohara T. FGF2 mediates mouse spermatogonial stem cell self-renewal via upregulation of Etv5 and Bcl6b through MAP2K1 activation. Development. 2012; 139: 1734-43.
    10. Horio M, Sato M, Takeyama Y, Elshazley M, Yamashita R, Hase T, Yoshida K, Usami N, Yokoi K, Sekido Y, Kondo M, Toyokuni S, Gazdar AF, Minna JD, Hasegawa Y. Transient but not stable ZEB1 knockdown dramatically inhibits growth of malignant pleural mesothelioma cells. Ann Surg Oncol. 2012; 19 Suppl 3: S634-45.
    11. Elshazley M, Sato M, Hase T, Yamashita R, Yoshida K, Toyokuni S, Ishiguro F, Osada H, Sekido Y, Yokoi K, Usami N, Shames DS, Kondo M, Gazdar AF, Minna JD, Hasegawa Y. The circadian clock gene BMAL1 is a novel therapeutic target for malignant pleural mesothelioma. Int J Cancer. 2012; 131: 2820-31.
    12. Akatsuka S, Yamashita Y, Ohara H, Liu YT, Izumiya M, Abe K, Ochiai M, Jiang L, Nagai H, Okazaki Y, Murakami H, Sekido Y, Arai E, Kanai Y, Hino O, Takahashi T, Nakagama H, Toyokuni S. Fenton reaction induced cancer in wild type rats recapitulates genomic alterations observed in human cancer. PLoS One. 2012; 7: e43403.
    13. Akatsuka S, Toyokuni S. Genome-wide assessment of oxidatively generated DNA damage. Free Radic Res. 2012; 46: 523-30.
  • 2011年
    1. Yamashita Y, Kajiura D, Tang L, Hasegawa Y, Kinoshita T, Nakamura S, Akatsuka S, Toyokuni S, Mori N. XCR1 expression and biased VH gene usage are distinct features of diffuse large B-cell lymphoma initially manifesting in the bone marrow. Am J Clin Pathol. 2011; 135: 556-64.
    2. Toyokuni S, Hirao A, Wada T, Nagai R, Date A, Yoshii T, Akatsuka S, Yamashita Y, Kawada A. Age- and sun exposure-dependent differences in 8-hydroxy-2'-deoxyguanosine and N-(carboxymethyl)lysine in human epidermis. J Clin Biochem Nutr. 2011; 49: 121-4.
    3. Toyokuni S. Mysterious link between iron overload and CDKN2A/2B. J Clin Biochem Nutr. 2011; 48: 46-9.
    4. Toyokuni S. Iron as a target of chemoprevention for longevity in humans. Free Radic Res. 2011; 45: 906-17.
    5. Ohara H, Akatsuka S, Nagai H, Liu YT, Jiang L, Okazaki Y, Yamashita Y, Nakamura T, Toyokuni S. Stage-specific roles of fibulin-5 during oxidative stress-induced renal carcinogenesis in rats. Free Radic Res. 2011; 45: 211-20.
    6. Nishikawa E, Osada H, Okazaki Y, Arima C, Tomida S, Tatematsu Y, Taguchi A, Shimada Y, Yanagisawa K, Yatabe Y, Toyokuni S, Sekido Y, Takahashi T. miR-375 is activated by ASH1 and inhibits YAP1 in a lineage-dependent manner in lung cancer. Cancer Res. 2011; 71: 6165-73.
    7. Nagai H, Okazaki Y, Chew SH, Misawa N, Yamashita Y, Akatsuka S, Ishihara T, Yamashita K, Yoshikawa Y, Yasui H, Jiang L, Ohara H, Takahashi T, Ichihara G, Kostarelos K, Miyata Y, Shinohara H, Toyokuni S. Diameter and rigidity of multiwalled carbon nanotubes are critical factors in mesothelial injury and carcinogenesis. Proc Natl Acad Sci U S A. 2011; 108: E1330-8.
    8. Nagai H, Ishihara T, Lee WH, Ohara H, Okazaki Y, Okawa K, Toyokuni S. Asbestos surface provides a niche for oxidative modification. Cancer Sci. 2011; 102: 2118-25.
    9. Murakami H, Mizuno T, Taniguchi T, Fujii M, Ishiguro F, Fukui T, Akatsuka S, Horio Y, Hida T, Kondo Y, Toyokuni S, Osada H, Sekido Y. LATS2 is a tumor suppressor gene of malignant mesothelioma. Cancer Res. 2011; 71: 873-83.
  • 2010年
    1. Toyokuni S. Toward a new era of the Nagoya journal of medical science: message from the new editor-in-chief. Nagoya J Med Sci. 2010; 72: 107-9.
    2. Shirase T, Mori K, Okazaki Y, Itoh K, Yamamoto M, Tabuchi M, Kishi F, Jiang L, Akatsuka S, Nakao K, Toyokuni S. Suppression of SLC11A2 expression is essential to maintain duodenal integrity during dietary iron overload. Am J Pathol. 2010; 177: 677-85.
    3. Okazaki Y, Iqbal M, Kawakami N, Yamamoto Y, Toyokuni S, Okada S. A beverage containing fermented black soybean ameliorates ferric nitrilotriacetate-induced renal oxidative damage in rats. J Clin Biochem Nutr. 2010; 47: 198-207.
    4. Nagai H, Toyokuni S. Biopersistent fiber-induced inflammation and carcinogenesis: lessons learned from asbestos toward safety of fibrous nanomaterials. Arch Biochem Biophys. 2010; 502: 1-7.
    5. Jiang L, Yamashita Y, Toyokuni S. A novel method for efficient collection of normal mesothelial cells in vivo. J Clin Biochem Nutr. 2010; 46: 265-8.
    6. Ishino K, Wakita C, Shibata T, Toyokuni S, Machida S, Matsuda S, Matsuda T, Uchida K. Lipid peroxidation generates body odor component trans-2-nonenal covalently bound to protein in vivo. J Biol Chem. 2010; 285: 15302-13.
    7. Hu Q, Akatsuka S, Yamashita Y, Ohara H, Nagai H, Okazaki Y, Takahashi T, Toyokuni S. Homozygous deletion of CDKN2A/2B is a hallmark of iron-induced high-grade rat mesothelioma. Lab Invest. 2010; 90: 360-73.
    8. Akatsuka S, Toyokuni S. Genome-scale approaches to investigate oxidative DNA damage. J Clin Biochem Nutr. 2010; 47: 91-7.
  • 2009年
    1. Zhong Y, Onuki J, Yamasaki T, Ogawa O, Akatsuka S, Toyokuni S. Genome-wide analysis identifies a tumor suppressor role for aminoacylase 1 in iron-induced rat renal cell carcinoma. Carcinogenesis. 2009; 30: 158-64.
    2. Toyokuni S. Role of iron in carcinogenesis: cancer as a ferrotoxic disease. Cancer Sci. 2009; 100: 9-16.
    3. Toyokuni S. Mechanisms of asbestos-induced carcinogenesis. Nagoya J Med Sci. 2009; 71: 1-10.
    4. Takashima S, Takehashi M, Lee J, Chuma S, Okano M, Hata K, Suetake I, Nakatsuji N, Miyoshi H, Tajima S, Tanaka Y, Toyokuni S, Sasaki H, Kanatsu-Shinohara M, Shinohara T. Abnormal DNA methyltransferase expression in mouse germline stem cells results in spermatogenic defects. Biol Reprod. 2009; 81: 155-64.
    5. Lee J, Kanatsu-Shinohara M, Morimoto H, Kazuki Y, Takashima S, Oshimura M, Toyokuni S, Shinohara T. Genetic reconstruction of mouse spermatogonial stem cell self-renewal in vitro by Ras-cyclin D2 activation. Cell Stem Cell. 2009; 5: 76-86.
    6. Hiraumi Y, Iwai-Kanai E, Baba S, Yui Y, Kamitsuji Y, Mizushima Y, Matsubara H, Watanabe M, Watanabe K, Toyokuni S, Matsubara H, Nakahata T, Adachi S. Granulocyte colony-stimulating factor protects cardiac mitochondria in the early phase of cardiac injury. Am J Physiol Heart Circ Physiol. 2009; 296: H823-32.
  • 2008年
    1. Yamaguchi K, Mandai M, Toyokuni S, Hamanishi J, Higuchi T, Takakura K, Fujii S. Contents of endometriotic cysts, especially the high concentration of free iron, are a possible cause of carcinogenesis in the cysts through the iron-induced persistent oxidative stress. Clin Cancer Res. 2008; 14: 32-40.
    2. Toyokuni S. Molecular mechanisms of oxidative stress-induced carcinogenesis: from epidemiology to oxygenomics. IUBMB Life. 2008; 60: 441-7.
    3. Jiang L, Nagai H, Ohara H, Hara S, Tachibana M, Hirano S, Shinohara Y, Kohyama N, Akatsuka S, Toyokuni S. Characteristics and modifying factors of asbestos-induced oxidative DNA damage. Cancer Sci. 2008; 99: 2142-51.
    4. Ishino K, Shibata T, Ishii T, Liu YT, Toyokuni S, Zhu X, Sayre LM, Uchida K. Protein N-acylation: H2O2-mediated covalent modification of protein by lipid peroxidation-derived saturated aldehydes. Chem Res Toxicol. 2008; 21: 1261-70.
  • 2007年
    1. Zhong Y, Jiang L, Hiai H, Toyokuni S, Yamada Y. Overexpression of a transcription factor LYL1 induces T- and B-cell lymphoma in mice. Oncogene. 2007; 26: 6937-47.
    2. Toyokuni S, Akatsuka S. Pathological investigation of oxidative stress in the post-genomic era. Pathol Int. 2007; 57: 461-73.
    3. Miyagawa-Hayashino A, Tsuruyama T, Egawa H, Haga H, Sakashita H, Okuno T, Toyokuni S, Tamaki K, Yamabe H, Manabe T, Uemoto S. FasL expression in hepatic antigen-presenting cells and phagocytosis of apoptotic T cells by FasL+ Kupffer cells are indicators of rejection activity in human liver allografts. Am J Pathol. 2007; 171: 1499-508.
    4. Liu YT, Shang D, Akatsuka S, Ohara H, Dutta KK, Mizushima K, Naito Y, Yoshikawa T, Izumiya M, Abe K, Nakagama H, Noguchi N, Toyokuni S. Chronic oxidative stress causes amplification and overexpression of ptprz1 protein tyrosine phosphatase to activate beta-catenin pathway. Am J Pathol. 2007; 171: 1978-88.
    5. Kanatsu-Shinohara M, Inoue K, Ogonuki N, Miki H, Yoshida S, Toyokuni S, Lee J, Ogura A, Shinohara T. Leukemia inhibitory factor enhances formation of germ cell colonies in neonatal mouse testis culture. Biol Reprod. 2007; 76: 55-62.
    6. Dutta KK, Zhong Y, Liu YT, Yamada T, Akatsuka S, Hu Q, Yoshihara M, Ohara H, Takehashi M, Shinohara T, Masutani H, Onuki J, Toyokuni S. Association of microRNA-34a overexpression with proliferation is cell type-dependent. Cancer Sci. 2007; 98: 1845-52.
  • 2006年
    1. Toyokuni S, Yasui H, Date A, Hakozaki T, Akatsuka S, Kohda H, Yoshii T, Sakurai H. Novel screening method for ultraviolet protection: combination of a human skin-equivalent model and 8-hydroxy-2'-deoxyguanosine. Pathol Int. 2006; 56: 760-2.
    2. Toyokuni S. Novel aspects of oxidative stress-associated carcinogenesis. Antioxid Redox Signal. 2006; 8: 1373-7.
    3. Akatsuka S, Aung TT, Dutta KK, Jiang L, Lee WH, Liu YT, Onuki J, Shirase T, Yamasaki K, Ochi H, Naito Y, Yoshikawa T, Kasai H, Tominaga Y, Sakumi K, Nakabeppu Y, Kawai Y, Uchida K, Yamasaki A, Tsuruyama T, Yamada Y, Toyokuni S. Contrasting genome-wide distribution of 8-hydroxyguanine and acrolein-modified adenine during oxidative stress-induced renal carcinogenesis. Am J Pathol. 2006; 169: 1328-42.
  • 2005年
    1. Ozeki M, Miyagawa-Hayashino A, Akatsuka S, Shirase T, Lee WH, Uchida K, Toyokuni S. Susceptibility of actin to modification by 4-hydroxy-2-nonenal. J Chromatogr B Analyt Technol Biomed Life Sci. 2005; 827: 119-26.
    2. Dutta KK, Nishinaka Y, Masutani H, Akatsuka S, Aung TT, Shirase T, Lee WH, Yamada Y, Hiai H, Yodoi J, Toyokuni S. Two distinct mechanisms for loss of thioredoxin-binding protein-2 in oxidative stress-induced renal carcinogenesis. Lab Invest. 2005; 85: 798-807.
  • 2004年
    1. Toyokuni S. Redox control of carcinogenesis and tumor biology. Antioxid Redox Signal. 2004; 6: 481-2.
    2. Tanaka T, Akatsuka S, Ozeki M, Shirase T, Hiai H, Toyokuni S. Redox regulation of annexin 2 and its implications for oxidative stress-induced renal carcinogenesis and metastasis. Oncogene. 2004; 23: 3980-9.
    3. Okumura H, Nagaya N, Itoh T, Okano I, Hino J, Mori K, Tsukamoto Y, Ishibashi-Ueda H, Miwa S, Tambara K, Toyokuni S, Yutani C, Kangawa K. Adrenomedullin infusion attenuates myocardial ischemia/reperfusion injury through the phosphatidylinositol 3-kinase/Akt-dependent pathway. Circulation. 2004; 109: 242-8.
    4. Okada M, Adachi S, Imai T, Watanabe K, Toyokuni SY, Ueno M, Zervos AS, Kroemer G, Nakahata T. A novel mechanism for imatinib mesylate-induced cell death of BCR-ABL-positive human leukemic cells: caspase-independent, necrosis-like programmed cell death mediated by serine protease activity. Blood. 2004; 103: 2299-307.
    5. Nishigori C, Hattori Y, Toyokuni S. Role of reactive oxygen species in skin carcinogenesis. Antioxid Redox Signal. 2004; 6: 561-70.
    6. Minamiyama Y, Takemura S, Toyokuni S, Imaoka S, Funae Y, Hirohashi K, Yoshikawa T, Okada S. CYP3A induction aggravates endotoxemic liver injury via reactive oxygen species in male rats. Free Radic Biol Med. 2004; 37: 703-12.
    7. Kanatsu-Shinohara M, Inoue K, Lee J, Yoshimoto M, Ogonuki N, Miki H, Baba S, Kato T, Kazuki Y, Toyokuni S, Toyoshima M, Niwa O, Oshimura M, Heike T, Nakahata T, Ishino F, Ogura A, Shinohara T. Generation of pluripotent stem cells from neonatal mouse testis. Cell. 2004; 119: 1001-12.
    8. Hiroyasu M, Akatsuka S, Shirase T, Toda Y, Hiai H, Toyokuni S. Detection of glyceraldehyde 3-phosphate dehydrogenase messenger RNA using a peptide nucleic acid probe in paraffin-embedded archival specimens. Pathol Int. 2004; 54: 251-5.
  • 2003年
    1. Toyokuni S, Tanaka T, Kawaguchi W, Fang NR, Ozeki M, Akatsuka S, Hiai H, Aruoma OI, Bahorun T. Effects of the phenolic contents of Mauritian endemic plant extracts on promoter activities of antioxidant enzymes. Free Radic Res. 2003; 37: 1215-24.
    2. Toyokuni S, Kawaguchi W, Akatsuka S, Hiroyasu M, Hiai H. Intermittent microwave irradiation facilitates antigen-antibody reaction in Western blot analysis. Pathol Int. 2003; 53: 259-61.
    3. Narushima S, Spitz DR, Oberley LW, Toyokuni S, Miyata T, Gunnett CA, Buettner GR, Zhang J, Ismail H, Lynch RG, Berg DJ. Evidence for oxidative stress in NSAID-induced colitis in IL10-/- mice. Free Radic Biol Med. 2003; 34: 1153-66.
    4. Kuroda K, Han H, Tani S, Tanigaki K, Tun T, Furukawa T, Taniguchi Y, Kurooka H, Hamada Y, Toyokuni S, Honjo T. Regulation of marginal zone B cell development by MINT, a suppressor of Notch/RBP-J signaling pathway. Immunity. 2003; 18: 301-12.
    5. Hashimoto M, Sibata T, Wasada H, Toyokuni S, Uchida K. Structural basis of protein-bound endogenous aldehydes. Chemical and immunochemical characterizations of configurational isomers of a 4-hydroxy-2-nonenal-histidine adduct. J Biol Chem. 2003; 278: 5044-51.
    6. Aoi W, Naito Y, Sakuma K, Kuchide M, Tokuda H, Maoka T, Toyokuni S, Oka S, Yasuhara M, Yoshikawa T. Astaxanthin limits exercise-induced skeletal and cardiac muscle damage in mice. Antioxid Redox Signal. 2003; 5: 139-44.
  • 2002年
    1. Yamagami K, Yamamoto Y, Toyokuni S, Hata K, Yamaoka Y. Heat shock preconditioning reduces the formation of 8-hydroxy-2'-deoxyguanosine and 4-hydroxy-2-nonenal modified proteins in ischemia-reperfused liver of rats. Free Radic Res. 2002; 36: 169-76.
    2. Toyokuni S. Iron and carcinogenesis: from Fenton reaction to target genes. Redox Rep. 2002; 7: 189-97.
    3. Nakamura K, Kusano K, Nakamura Y, Kakishita M, Ohta K, Nagase S, Yamamoto M, Miyaji K, Saito H, Morita H, Emori T, Matsubara H, Toyokuni S, Ohe T. Carvedilol decreases elevated oxidative stress in human failing myocardium. Circulation. 2002; 105: 2867-71.
    4. Miyawaki K, Yamada Y, Ban N, Ihara Y, Tsukiyama K, Zhou H, Fujimoto S, Oku A, Tsuda K, Toyokuni S, Hiai H, Mizunoya W, Fushiki T, Holst JJ, Makino M, Tashita A, Kobara Y, Tsubamoto Y, Jinnouchi T, Jomori T, Seino Y. Inhibition of gastric inhibitory polypeptide signaling prevents obesity. Nat Med. 2002; 8: 738-42.
    5. Miwa S, Toyokuni S, Nishina T, Nomoto T, Hiroyasu M, Nishimura K, Komeda M. Spaciotemporal alteration of 8-hydroxy-2'-deoxyguanosine levels in cardiomyocytes after myocardial infarction in rats. Free Radic Res. 2002; 36: 853-8.
    6. Kondo S, Toyokuni S, Tsuruyama T, Ozeki M, Tachibana T, Echizenya M, Hiai H, Onodera H, Imamura M. Peroxynitrite-mediated stress is associated with proliferation of human metastatic colorectal carcinoma in the liver. Cancer Lett. 2002; 179: 87-93.
    7. Kanatsu-Shinohara M, Ogura A, Ikegawa M, Inoue K, Ogonuki N, Tashiro K, Toyokuni S, Honjo T, Shinohara T. Adenovirus-mediated gene delivery and in vitro microinsemination produce offspring from infertile male mice. Proc Natl Acad Sci U S A. 2002; 99: 1383-8.
    8. Hiroyasu M, Ozeki M, Miyagawa-Hayashino A, Fujiwara Y, Hiai H, Toyokuni S. Novel surrogate end-point biomarker to evaluate agents for use in the chemoprevention of reactive oxygen species-associated cancer. Redox Rep. 2002; 7: 335-8.
    9. Hiroyasu M, Ozeki M, Kohda H, Echizenya M, Tanaka T, Hiai H, Toyokuni S. Specific allelic loss of p16 (INK4A) tumor suppressor gene after weeks of iron-mediated oxidative damage during rat renal carcinogenesis. Am J Pathol. 2002; 160: 419-24.
    10. Ban N, Yamada Y, Someya Y, Miyawaki K, Ihara Y, Hosokawa M, Toyokuni S, Tsuda K, Seino Y. Hepatocyte nuclear factor-1alpha recruits the transcriptional co-activator p300 on the GLUT2 gene promoter. Diabetes. 2002; 51: 1409-18.
  • 2001年
    1. Toyokuni S, Masumizu T, Ozeki M, Kondo S, Hiroyasu M, Kohno M, Hiai H. An electron spin resonance study on alkylperoxyl radical in thin-sliced renal tissues from ferric nitrilotriacetate-treated rats: the effect of alpha-tocopherol feeding. Free Radic Res. 2001; 35: 245-55.
    2. Mori M, Toyokuni S, Kondo S, Kasai H, Naiki H, Toichi E, Hosokawa M, Higuchi K. Spontaneous loss-of-function mutations of the 8-oxoguanine DNA glycosylase gene in mice and exploration of the possible implication of the gene in senescence. Free Radic Biol Med. 2001; 30: 1130-6.
  • 2000年
    1. Yamagami K, Yamamoto Y, Kume M, Ishikawa Y, Yamaoka Y, Hiai H, Toyokuni S. Formation of 8-hydroxy-2'-deoxyguanosine and 4-hydroxy-2-nonenal-modified proteins in rat liver after ischemia-reperfusion: distinct localization of the two oxidatively modified products. Antioxid Redox Signal. 2000; 2: 127-36.
    2. Toyokuni S, Yamada S, Kashima M, Ihara Y, Yamada Y, Tanaka T, Hiai H, Seino Y, Uchida K. Serum 4-hydroxy-2-nonenal-modified albumin is elevated in patients with type 2 diabetes mellitus. Antioxid Redox Signal. 2000; 2: 681-5.
    3. Tanaka T, Kondo S, Iwasa Y, Hiai H, Toyokuni S. Expression of stress-response and cell proliferation genes in renal cell carcinoma induced by oxidative stress. Am J Pathol. 2000; 156: 2149-57.
    4. Kondo S, Toyokuni S, Tanaka T, Hiai H, Onodera H, Kasai H, Imamura M. Overexpression of the hOGG1 gene and high 8-hydroxy-2'-deoxyguanosine (8-OHdG) lyase activity in human colorectal carcinoma: regulation mechanism of the 8-OHdG level in DNA. Clin Cancer Res. 2000; 6: 1394-400.
  • 1999年
    1. Toyokuni S. Reactive oxygen species-induced molecular damage and its application in pathology. Pathol Int. 1999; 49: 91-102.
    2. Tanaka T, Iwasa Y, Kondo S, Hiai H, Toyokuni S. High incidence of allelic loss on chromosome 5 and inactivation of p15INK4B and p16INK4A tumor suppressor genes in oxystress-induced renal cell carcinoma of rats. Oncogene. 1999; 18: 3793-7.
  • 1997年
    1. Toyokuni S, Tanaka T, Hattori Y, Nishiyama Y, Yoshida A, Uchida K, Hiai H, Ochi H, Osawa T. Quantitative immunohistochemical determination of 8-hydroxy-2'-deoxyguanosine by a monoclonal antibody N45.1: its application to ferric nitrilotriacetate-induced renal carcinogenesis model. Lab Invest. 1997; 76: 365-74.
    2. Toyokuni S, Luo XP, Tanaka T, Uchida K, Hiai H, Lehotay DC. Induction of a wide range of C(2-12) aldehydes and C(7-12) acyloins in the kidney of Wistar rats after treatment with a renal carcinogen, ferric nitrilotriacetate. Free Radic Biol Med. 1997; 22: 1019-27.
  • 1996年
    1. Toyokuni S. Iron-induced carcinogenesis: the role of redox regulation. Free Radic Biol Med. 1996; 20: 553-66.
    2. Okamoto K, Toyokuni S, Kim WJ, Ogawa O, Kakehi Y, Arao S, Hiai H, Yoshida O. Overexpression of human mutT homologue gene messenger RNA in renal-cell carcinoma: evidence of persistent oxidative stress in cancer. Int J Cancer. 1996; 65: 437-41.
    3. Hattori Y, Nishigori C, Tanaka T, Uchida K, Nikaido O, Osawa T, Hiai H, Imamura S, Toyokuni S. 8-hydroxy-2'-deoxyguanosine is increased in epidermal cells of hairless mice after chronic ultraviolet B exposure. J Invest Dermatol. 1996; 107: 733-7.
    4. Fukuda A, Osawa T, Oda H, Toyokuni S, Satoh K, Uchida K. Oxidative stress response in iron-induced renal carcinogenesis: acute nephrotoxicity mediates the enhanced expression of glutathione S-transferase Yp isozyme. Arch Biochem Biophys. 1996; 329: 39-46.
    5. Fukuda A, Osawa T, Oda H, Tanaka T, Toyokuni S, Uchida K. Oxidative stress response in iron-induced acute nephrotoxicity: enhanced expression of heat shock protein 90. Biochem Biophys Res Commun. 1996; 219: 76-81.
  • 1995年
    1. Uchida K, Osawa T, Hiai H, Toyokuni S. 4-Hydroxy-2-nonenal-trapping ELISA: direct evidence for the release of a cytotoxic aldehyde from oxidized low density lipoproteins. Biochem Biophys Res Commun. 1995; 212: 1068-73.
    2. Uchida K, Itakura K, Kawakishi S, Hiai H, Toyokuni S, Stadtman ER. Characterization of epitopes recognized by 4-hydroxy-2-nonenal specific antibodies. Arch Biochem Biophys. 1995; 324: 241-8.
    3. Uchida K, Fukuda A, Kawakishi S, Toyokuni S, Hiai H, Ikeda S, Horio F. Acute nephrotoxicity of a carcinogenic iron chelate. Selective inhibition of a proteolytic conversion of alpha 2U-globulin to the kidney fatty acid-binding protein. FEBS Lett. 1995; 357: 165-7.
  • 1994年
    1. Toyokuni S, Uchida K, Okamoto K, Hattori-Nakakuki Y, Hiai H, Stadtman ER. Formation of 4-hydroxy-2-nonenal-modified proteins in the renal proximal tubules of rats treated with a renal carcinogen, ferric nitrilotriacetate. Proc Natl Acad Sci U S A. 1994; 91: 2616-20.
  • 1990年
    1. Toyokuni S, Okada S, Hamazaki S, Minamiyama Y, Yamada Y, Liang P, Fukunaga Y, Midorikawa O. Combined histochemical and biochemical analysis of sex hormone dependence of ferric nitrilotriacetate-induced renal lipid peroxidation in ddY mice. Cancer Res. 1990; 50: 5574-80.

研究キーワード

酸化ストレス、鉄代謝、アスベスト、カーボンナノチューブ、中皮腫、低温プラズマ、動物発がんモデル、オキシゲノミクス、がん予防、軟部腫瘍

その他

熱意のある修士課程・博士課程の大学院生を常時募集しています。