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がん疫学・遺伝学（連携）がん分析疫学（愛知県がんセンター）

概要

名古屋市千種区にある愛知県がんセンター研究所 がん予防研究分野は、がんに関する疫学研究を実施しています。本研究室では、従来からの生活習慣、環境要因のがんリスクに対する影響を評価する疫学研究のみならず、遺伝的背景のがんリスクへの評価を行う分子疫学、それらのがん予防への応用研究も行っております。同研究所 がん情報・対策研究分野とも連携し、よりがん疫学に記述疫学的な側面も取り入れております。また、臨床研究グループと共同した臨床疫学研究も数多く実施しております。がんに対する疫学研究組織として、規模・実績ともに、全国でトップクラスです。

詳しくは、がん予防研究分野（http://www.pref.aichi.jp/cancer-center/ri/01bumon/04idenshi_iryo/index.html）のホームページをご覧ください。

研究プロジェクト

当センターでは、1988年から2013年の間、愛知県がんセンター中央病院外来において、初診患者さんを対象に、HERPACC(Hospital-based Epidemiologic Research Program at Aichi Cancer Center)と呼ばれる大規模な研究を実施してきました。がん、非がんの患者さんが混在する集団を対象に、生活習慣、採血を含む疫学調査を行ってきました。本研究は下記に触れる様々な研究プロジェクトの大元となっており、予防、臨床の両方につながる疫学研究を展開しています。

１．がんの罹患リスクを検討する研究
がんに罹りやすい人、罹りにくい人の違いにどういう背景があるかを探す研究を実施しています。生活習慣を初めとする環境要因、遺伝子に基づく宿主要因、および両者の交互作用を解明し、それらをがんリスクを評価する事にどう用いるかを検討しています。
i) がんのリスクに影響を与える環境要因を検討する研究
ii) がんのリスクに影響を与える遺伝的要因を検討する研究
iii) 環境要因と遺伝的要因の交互作用を明らかにする研究
iv) i)-iv)を組合わせた、がんリスク予測に関する研究
v) がんの個性によるリスク要因の違いに関する研究
i〜iv)を総合した研究の実例として以下に食道がん・頭頸部食道がんリスクに対する雅飲酒とALDH2遺伝子多型の交互作用を用いたリスク予測の研究の論文リンクを参照 （https://www.ncbi.nlm.nih.gov/pubmed/26862830）。 　
同研究では、HERPACC第2期の症例対照研究で、飲酒とALDH2遺伝子型、喫煙、性、年齢情報に基づき頭頸部・食道がんのリスクを予測するモデルを作成しました。モデルが妥当かどうかを、HERPACC第3期の症例対照研究で検証し、再現性があることを確認しました。同研究では、さらに飲酒量とALDH2遺伝子型の組合わせ別に頭頸部・食道がんの罹患リスクの推定を行っています。

２．がんサバイバーシップ研究 　

がんに罹った後の生存に最も影響を与えるものは治療です。しかしながら、治療に加えてより良い生活習慣、あるいは治療効果をよくする遺伝的背景があるかもしれません。我々は愛知県がんセンター中央病院と協力して、生活習慣や遺伝的背景がどのようにがん患者さんの治療成績と関係しているかを探る検討をしています。将来的には、治療成績が向上するために必要な生活習慣は何か、を提案できるようにしたいと考えています。 　本研究の実例として、葉酸摂取と頭頸部がんの予後に関する研究を紹介します。 （https://www.ncbi.nlm.nih.gov/pubmed/21460376） 　
同研究では、愛知県がんセンターで頭頸部がんと診断され治療を受けた患者さん437名の治療後の予後が、葉酸摂取量（診断前の食事パターンに基づく）が高い患者さんでは良好である、という結果を得ました。今後、がんの種類を広げて、治療後の生活習慣などの治療成績への影響を調べる研究を展開していく予定です。

３．国際共同研究への参画 　

がんは日本だけで起きている訳ではなく、世界中で起きています。その原因は、日本人特有なものもあれば、そうではなく人類共通のものである可能性もあります。これらを明らかにするために世界中の研究者と共同して研究するプラットフォームに参画しています。現在参画している国際コンソーシアムは以下の通りです。
i) International Head and Neck Cancer Epidemiology Consortium (INHANCE) (http://www.inhance.utah.edu/)
ii) International Lung Cancer Consortium (ILCCO) (http://ilcco.iarc.fr/)
iii) Breast Cancer Association Consortium (BCAC) iv) Ovarian Cancer Association Consortium (OCAC)
v) Collaborative Oncological Gene-environment Study (COGS) (BCAC/OCAC/COGS http://www.cogseu.org/)
vi) International Lymphoma Epidemiology Consortium (InterLymph https://epi.grants.cancer.gov/InterLymph/#membership)
vii) Asia Cohort Consortium (https://www.asiacohort.org/) 　
これらの研究を通じて、これまでにN Engl J Med、Nature Geneticsなどに成果を発表しています。
本国際共同研究の例として、二つの論文リンクを紹介します。 　
一つ目はvii)のアジアコホートコンソーシアムを通じた研究です。
（https://www.ncbi.nlm.nih.gov/pubmed/21345101）本検討では、アジア人を対象として実施された19のコホート研究をプールし、Body Mass Index の総死亡、癌死亡、循環器死亡への影響を検討しました。
二つ目は、iii)の乳がんに関する研究です。
（https://www.ncbi.nlm.nih.gov/pubmed/23535729）本検討は、BCAC,に参画する疫学研究を対象に全ゲノム関連解析研究を実施したところ、乳がんリスクに影響を与える41遺伝子座見つかった、という研究です。

４．乳がんに対する環境要因、宿主要因情報を用いた予防介入研究

乳がんはわが国の女性の罹患第一位のがんです。これまでに数多くの研究が環境要因、宿主要因それぞれに関して乳がんリスクとの関連を示してきましたが、それらを組み合せて評価されたことは国内では皆無でした。我々の研究グループでは日本医療研究開発機構AMEDより「個人の生活習慣等の環境要因と遺伝的リスクを考慮した科学的根拠に基づく効率的な乳がん予防法の開発研究」の課題名で支援頂き、国立がん研究センター、鹿児島大学、国立保健医療科学院、徳島大学、大阪大学と連携し、①環境要因と宿主要因を用いた乳がんリスク予測モデル構築、②リスク予測モデルを用いた予防介入試験、③リスク予測を考慮した予防の経済効果予測、④リスク予測を用いた予防法の公衆衛生学的効果の予測を行う研究を実施しています。

５．日本人を対象としたがん予防法の検討

日本で数多くの疫学研究が実施されて来ましたが、それらを総合的に評価し、日本人のためのがん予防はどうあるべきか、という事を評価する事も重要であると考えています。我々は国立がん研究センターのグループが中心となって推進している「科学的根拠に基づく発癌性・がん予防効果の評価とがん予防ガイドライン提言に関する研究」班に参画し、積極的に日本人のがん予防に資するエビデンスの構築に関っています。
（http://epi.ncc.go.jp/can_prev/）

６．日本他施設共同コーホート研究　(J-MICC研究) 　

当センターは日本多施設共同コーホート研究、通称J-MICC研究に１研究サイトとして参画しております。（http://www.jmicc.com/）J-MICC研究は日本で初めての本格的且つ大規模な分子疫学コホート研究です。

７．3府県コホート研究

愛知 　名古屋市千種区と豊田市足助町において1985年に立ち上げられた住民ベースのコホート研究です。対象者数は33,529名であり、他の3府県コホート（大阪府、宮城県）と共同し、現在までに数多くの成果を出してきました。本データを用いてAsia Cohort Consortium、日本人を対象としたがん予防法開発研究にも参画しています。 （http://jeaweb.jp/activities/cohort.html）

８．臨床疫学研究

我々は愛知県がんセンター中央病院のみならず、名古屋大学をはじめ国内外の研究機関において実施される臨床研究に疫学・統計の立場で支援を行っています。

教員

構成員名役職所属
松尾　恵太郎 連携教授 疫学

研究実績

  • 2019年
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    2. Oze I, Ito H, Nishino Y, et al. Trends in Small-Cell Lung Cancer Survival in 1993-2006 Based on Population-Based Cancer Registry Data in Japan. J Epidemiol. 2019;29(9):347-353. doi: 310.2188/jea.JE20180112. Epub 20182018 Nov 20180117.
    3. Islam Z, Akter S, Kashino I, et al. Meat subtypes and colorectal cancer risk: A pooled analysis of 6 cohort studies in Japan. Cancer Sci. 2019;4(10):14188.
    4. Okada R, Kadomatsu Y, Tsukamoto M, et al. Combined effect of weight gain within normal weight range and parental hypertension on the prevalence of hypertension; from the J-MICC Study. J Hum Hypertens. 2019;3(10):019-0230.
    5. Oze I, Charvat H, Matsuo K, et al. Revisit of an unanswered question by pooled analysis of eight cohort studies in Japan: Does cigarette smoking and alcohol drinking have interaction for the risk of esophageal cancer? Cancer Med. 2019;1(10).
    6. Dork T, Peterlongo P, Mannermaa A, et al. Two truncating variants in FANCC and breast cancer risk. Sci Rep. 2019;9(1):12524. doi: 12510.11038/s41598-12019-48804-y.
    7. Ugai T, Ito H, Oze I, et al. Association of BMI, smoking and alcohol with multiple myeloma mortality in Asians: a pooled analysis of more than 800,000 participants in the Asia Cohort Consortium. Cancer Epidemiol Biomarkers Prev. 2019;9:1055-9965.
    8. Abe SK, Saito E, Sawada N, et al. Green tea consumption and mortality in Japanese men and women: a pooled analysis of eight population-based cohort studies in Japan. Eur J Epidemiol. 2019;7(10):019-00545.
    9. Koyanagi YN, Ito H, Matsuo K, et al. Smoking and Pancreatic Cancer Incidence: A Pooled Analysis of 10 Population-Based Cohort Studies in Japan. Cancer Epidemiol Biomarkers Prev. 2019;28(8):1370-1378. doi: 1310.1158/1055-9965.EPI-1318-1327. Epub 2019 May 1321.
    10. Wong JYY, Zhang H, Hsiung CA, et al. Tuberculosis infection and lung adenocarcinoma: Mendelian randomization and pathway analysis of genome-wide association study data from never- smoking Asian women. Genomics. 2019;12(19):30112-30110.
    11. Hishida A, Ugai T, Fujii R, et al. GWAS analysis reveals a significant contribution of PSCA to the risk of Heliobacter pylori-induced gastric atrophy. Carcinogenesis. 2019;40(5):661-668. doi: 610.1093/carcin/bgz1016.
    12. Di Credico G, Edefonti V, Polesel J, et al. Joint effects of intensity and duration of cigarette smoking on the risk of head and neck cancer: A bivariate spline model approach. Oral Oncol. 2019;94:47-57.(doi):10.1016/j.oraloncology.2019.1005.1006. Epub 2019 May 1017.
    13. Masaoka H, Matsuo K, Oze I, et al. Alcohol drinking and bladder cancer risk from a pooled analysis of ten cohort studies in Japan. J Epidemiol. 2019;15(10).
    14. Ishikura N, Usui Y, Ito H, et al. Helicobacter pylori (HP) infection alone, but not HP-induced atrophic gastritis, increases the risk of gastric lymphoma: a case-control study in Japan. Ann Hematol. 2019;98(8):1981-1987. doi: 1910.1007/s00277-00019-03721-y. Epub 02019 Jun 00278.
    15. Ugai T, Milne RL, Ito H, et al. The functional ALDH2 polymorphism is associated with breast cancer risk: A pooled analysis from the Breast Cancer Association Consortium. Mol Genet Genomic Med. 2019;7(6):e707. doi: 710.1002/mgg1003.1707. Epub 2019 May 1007.
    16. Lawrenson K, Song F, Hazelett DJ, et al. Genome-wide association studies identify susceptibility loci for epithelial ovarian cancer in east Asian women. Gynecol Oncol. 2019;153(2):343-355. doi: 310.1016/j.ygyno.2019.1002.1023. Epub 2019 Mar 1019.
    17. Sueoka E, Watanabe T, Mashima T, et al. Meeting report of the 14th Japan-Korea joint symposium on cancer and aging research: current status of translational research and approaches to precision medicine. J Cancer Res Clin Oncol. 2019;145(5):1263-1271. doi: 1210.1007/s00432-00019-02887-00432. Epub 02019 Mar 00411.
    18. Yoshida T, Hijioka S, Hosoda W, et al. Surgery for Pancreatic Neuroendocrine Tumor G3 and Carcinoma G3 Should be Considered Separately. Ann Surg Oncol. 2019;26(5):1385-1393. doi: 1310.1245/s10434-10019-07252-10438. Epub 12019 Mar 10412.
    19. Tanikawa C, Kamatani Y, Terao C, et al. Novel Risk Loci Identified in a Genome-Wide Association Study of Urolithiasis in a Japanese Population. J Am Soc Nephrol. 2019;30(5):855-864. doi: 810.1681/ASN.2018090942. Epub 2018092019 Apr 2018090911.
    20. Nakatochi M, Kanai M, Nakayama A, et al. Genome-wide meta-analysis identifies multiple novel loci associated with serum uric acid levels in Japanese individuals. Commun Biol. 2019;2:115.(doi):10.1038/s42003-42019-40339-42000. eCollection 42019.
    21. Yang JJ, Yu D, Wen W, et al. Association of Diabetes With All-Cause and Cause-Specific Mortality in Asia: A Pooled Analysis of More Than 1 Million Participants. JAMA Netw Open. 2019;2(4):e192696. doi: 192610.191001/jamanetworkopen.192019.192696.
    22. Abe SK, Saito E, Sawada N, et al. Coffee consumption and mortality in Japanese men and women: A pooled analysis of eight population-based cohort studies in Japan (Japan Cohort Consortium). Prev Med. 2019;123:270-277.(doi):10.1016/j.ypmed.2019.1004.1002. Epub 2019 Apr 1012.
    23. Lu Y, Kweon SS, Tanikawa C, et al. Large-Scale Genome-Wide Association Study of East Asians Identifies Loci Associated With Risk for Colorectal Cancer. Gastroenterology. 2019;156(5):1455-1466. doi: 1410.1053/j.gastro.2018.1411.1066. Epub 2018 Dec 1456.
    24. Akizuki S, Ishigaki K, Kochi Y, et al. PLD4 is a genetic determinant to systemic lupus erythematosus and involved in murine autoimmune phenotypes. Ann Rheum Dis. 2019;78(4):509-518. doi: 510.1136/annrheumdis-2018-214116. Epub 212019 Jan 214124.
    25. Sado J, Kitamura T, Kitamura Y, et al. Coffee Consumption and All-Cause and Cardiovascular Mortality- Three- Prefecture Cohort in Japan. Circ J. 2019;83(4):757-766. doi: 710.1253/circj.CJ-1218-0618. Epub 2019 Mar 1258.
    26. Ishiguro J, Ito H, Tsukamoto M, Iwata H, Nakagawa H, Matsuo K. A functional single nucleotide polymorphism in ABCC11, rs17822931, is associated with the risk of breast cancer in Japanese. Carcinogenesis. 2019;40(4):537-543. doi: 510.1093/carcin/bgz1005.
    27. Sugita J, Kagaya Y, Miyamoto T, et al. Myeloablative and reduced-intensity conditioning in HLA-haploidentical peripheral blood stem cell transplantation using post-transplant cyclophosphamide. Bone Marrow Transplant. 2019;54(3):432-441. doi: 410.1038/s41409-41018-40279-41401. Epub 42018 Aug 41407.
    28. Yang JJ, Yu D, Wen W, et al. Tobacco Smoking and Mortality in Asia: A Pooled Meta-analysis. JAMA Netw Open. 2019;2(3):e191474. doi: 191410.191001/jamanetworkopen.192019.191474.
    29. Hasegawa T, Kuroda H, Sato Y, et al. The Utility of Indigo Carmine and Lipiodol Mixture for Preoperative Pulmonary Nodule Localization before Video-Assisted Thoracic Surgery. J Vasc Interv Radiol. 2019;30(3):446-452. doi: 410.1016/j.jvir.2018.1008.1024.
    30. Ninomiya T, Ishikawa N, Inoue K, et al. Phase 2 Study of Afatinib Alone or Combined With Bevacizumab in Chemonaive Patients With Advanced Non-Small-Cell Lung Cancer Harboring EGFR Mutations: AfaBev-CS Study Protocol. Clin Lung Cancer. 2019;20(2):134-138. doi: 110.1016/j.cllc.2018.1010.1008. Epub 2018 Nov 1011.
    31. Kotani H, Ito H, Kuwahara K, et al. Impact of germinal center-associated nuclear protein polymorphisms on breast cancer risk and prognosis in a Japanese population. Breast Cancer. 2019;26(5):562-572. doi: 510.1007/s12282-12019-00956-12285. Epub 12019 Feb 12227.
    32. Ranjit M, Hirano M, Aoki K, et al. Aberrant Active cis-Regulatory Elements Associated with Downregulation of RET Finger Protein Overcome Chemoresistance in Glioblastoma. Cell Rep. 2019;26(9):2274-2281.e2275. doi: 2210.1016/j.celrep.2019.2201.2109.
    33. Inoue S, Ito H, Hosono S, et al. Net Survival of Elderly Patients with Gynecological Cancer Aged Over 75 Years in 2006-2008. Asian Pac J Cancer Prev. 2019;20(2):437-442. doi: 410.31557/APJCP.32019.31520.31552.31437.
    34. Mori M, Hira A, Yoshida K, et al. Pathogenic mutations identified by a multimodality approach in 117 Japanese Fanconi anemia patients. Haematologica. 2019;21(207241):207241.
    35. Onishi S, Sawaki M, Ishiguro J, et al. The overall survival of breast cancer patients without adjuvant therapy. Surg Today. 2019;49(7):610-620. doi: 610.1007/s00595-00019-01775-z. Epub 02019 Feb 00597.
    36. Natsume S, Shimizu Y, Senda Y, et al. Conversion surgery only for highly selected patients with unresectable pancreatic cancer: a satisfactory outcome in exchange for a lower resection rate. Surg Today. 2019;49(8):670-677. doi: 610.1007/s00595-00019-01776-y. Epub 02019 Feb 00597.
    37. Yabe M, Koike T, Ohtsubo K, et al. Associations of complementation group, ALDH2 genotype, and clonal abnormalities with hematological outcome in Japanese patients with Fanconi anemia. Ann Hematol. 2019;98(2):271-280. doi: 210.1007/s00277-00018-03517-00270. Epub 02018 Oct 00227.
    38. Brenner DR, Fehringer G, Zhang ZF, et al. Alcohol consumption and lung cancer risk: A pooled analysis from the International Lung Cancer Consortium and the SYNERGY study. Cancer Epidemiol. 2019;58:25-32.(doi):10.1016/j.canep.2018.1010.1006. Epub 2018 Nov 1013.
    39. Schmit SL, Edlund CK, Schumacher FR, et al. Novel Common Genetic Susceptibility Loci for Colorectal Cancer. J Natl Cancer Inst. 2019;111(2):146-157. doi: 110.1093/jnci/djy1099.
    40. Yang Y, Wu L, Shu X, et al. Genetic Data from Nearly 63,000 Women of European Descent Predicts DNA Methylation Biomarkers and Epithelial Ovarian Cancer Risk. Cancer Res. 2019;79(3):505-517. doi: 510.1158/0008-5472.CAN-1118-2726. Epub 2018 Dec 1117.
    41. Shimanoe C, Hachiya T, Hara M, et al. A genome-wide association study of coping behaviors suggests FBXO45 is associated with emotional expression. Genes Brain Behav. 2019;18(2):e12481. doi: 12410.11111/gbb.12481. Epub 12018 May 12411.
    42. Takeuchi F, Kukimoto I, Li Z, et al. Genome-wide association study of cervical cancer suggests a role for ARRDC3 gene in human papillomavirus infection. Hum Mol Genet. 2019;28(2):341-348. doi: 310.1093/hmg/ddy1390.
  • 2018年
    1. Terao C, Yoshifuji H, Matsumura T, et al. Genetic determinants and an epistasis of LILRA3 and HLA-B 52 in Takayasu arteritis. Proc Natl Acad Sci U S A. 2018;115(51):13045-13050. doi: 13010.11073/pnas.1808850115. Epub 1808852018 Nov 1808850129.
    2. Tanikawa C, Kamatani Y, Toyoshima O, et al. Genome-wide association study identifies gastric cancer susceptibility loci at 12q24.11-12 and 20q11.21. Cancer Sci. 2018;109(12):4015-4024. doi: 4010.1111/cas.13815. Epub 12018 Oct 13831.
    3. Hara M, Hachiya T, Sutoh Y, et al. Genomewide Association Study of Leisure-Time Exercise Behavior in Japanese Adults. Med Sci Sports Exerc. 2018;50(12):2433-2441. doi: 2410.1249/MSS.0000000000001712.
    4. Leoncini E, Vukovic V, Cadoni G, et al. Tumour stage and gender predict recurrence and second primary malignancies in head and neck cancer: a multicentre study within the INHANCE consortium. Eur J Epidemiol. 2018;33(12):1205-1218. doi: 1210.1007/s10654-10018-10409-10655. Epub 12018 May 10619.
    5. Shimizu Y, Hijioka S, Hirono S, et al. New Model for Predicting Malignancy in Patients With Intraductal Papillary Mucinous Neoplasm. Ann Surg. 2018;29(10):0000000000003108.
    6. Miki A, Sakurada Y, Tanaka K, et al. Genome-Wide Association Study to Identify a New Susceptibility Locus for Central Serous Chorioretinopathy in the Japanese Population. Invest Ophthalmol Vis Sci. 2018;59(13):5542-5547. doi: 5510.1167/iovs.5518-25497.
    7. Tamura T, Kadomatsu Y, Tsukamoto M, et al. Association of exposure level to passive smoking with hypertension among lifetime nonsmokers in Japan: a cross-sectional study. Medicine (Baltimore). 2018;97(48):e13241. doi: 13210.11097/MD.0000000000013241.
    8. Ishioka K, Masaoka H, Ito H, et al. Association between ALDH2 and ADH1B polymorphisms, alcohol drinking and gastric cancer: a replication and mediation analysis. Gastric Cancer. 2018;21(6):936-945. doi: 910.1007/s10120-10018-10823-10120. Epub 12018 Apr 10123.
    9. Yoshimura A, Ito H, Nishino Y, et al. Recent Improvement in the Long-term Survival of Breast Cancer Patients by Age and Stage in Japan. J Epidemiol. 2018;28(10):420-427. doi: 410.2188/jea.JE20170103. Epub 20172018 Feb 20170124.
    10. Nakatochi M, Lin Y, Ito H, et al. Prediction model for pancreatic cancer risk in the general Japanese population. PLoS One. 2018;13(9):e0203386. doi: 0203310.0201371/journal.pone.0203386. eCollection 0202018.
    11. Hatta Y, Mizuta S, Matsuo K, et al. Final analysis of the JALSG Ph+ALL202 study: tyrosine kinase inhibitor- combined chemotherapy for Ph+ALL. Ann Hematol. 2018;97(9):1535-1545. doi: 1510.1007/s00277-00018-03323-00278. Epub 02018 Apr 00224.
    12. Kameda K, Kimura SI, Misaki Y, et al. Associations between febrile neutropenia-related parameters and the risk of acute GVHD or non-relapse mortality after allogeneic hematopoietic stem cell transplantation. Bone Marrow Transplant. 2019;54(5):707-716. doi: 710.1038/s41409-41018-40330-41402. Epub 42018 Aug 41431.
    13. Fujii R, Hishida A, Nakatochi M, et al. Association of genetic risk score and chronic kidney disease in a Japanese population. Nephrology (Carlton). 2019;24(6):670-673. doi: 610.1111/nep.13479. Epub 12019 Apr 13429.
    14. Yamagishi K, Iso H, Shimazu T, et al. Fish intake and risk of mortality due to aortic dissection and aneurysm: A pooled analysis of the Japan cohort consortium. Clin Nutr. 2019;38(4):1678-1683. doi: 1610.1016/j.clnu.2018.1608.1007. Epub 2018 Aug 1616.
    15. Wakahashi S, Kawakami F, Wakahashi K, et al. Transformed Follicular Lymphoma (TFL) Predicts Outcome in Advanced Endometrial Cancer. Cancer Epidemiol Biomarkers Prev. 2018;27(8):963-969. doi: 910.1158/1055-9965.EPI-1117-0762. Epub 2018 May 1121.
    16. Kashino I, Akter S, Mizoue T, et al. Coffee drinking and colorectal cancer and its subsites: A pooled analysis of 8 cohort studies in Japan. Int J Cancer. 2018;143(2):307-316. doi: 310.1002/ijc.31320. Epub 32018 Mar 31328.
    17. Earp M, Tyrer JP, Winham SJ, et al. Variants in genes encoding small GTPases and association with epithelial ovarian cancer susceptibility. PLoS One. 2018;13(7):e0197561. doi: 0197510.0191371/journal.pone.0197561. eCollection 0192018.
    18. Ferro A, Morais S, Rota M, et al. Alcohol intake and gastric cancer: Meta-analyses of published data versus individual participant data pooled analyses (StoP Project). Cancer Epidemiol. 2018;54:125-132.(doi):10.1016/j.canep.2018.1004.1009. Epub 2018 May 1016.
    19. Abe M, Shivappa N, Ito H, et al. Dietary inflammatory index and risk of upper aerodigestive tract cancer in Japanese adults. Oncotarget. 2018;9(35):24028-24040. doi: 24010.18632/oncotarget.25288. eCollection 22018 May 24028.
    20. Koyanagi YN, Matsuo K, Ito H, et al. Body-Mass Index and Pancreatic Cancer Incidence: A Pooled Analysis of Nine Population-Based Cohort Studies With More Than 340,000 Japanese Subjects. J Epidemiol. 2018;28(5):245-252. doi: 210.2188/jea.JE20160193. Epub 20162017 Dec 20160199.
    21. Toyooka S, Okumura N, Nakamura H, et al. A Multicenter Randomized Controlled Study of Paclitaxel plus Carboplatin versus Oral Uracil-Tegafur as the Adjuvant Chemotherapy in Resected Non- Small Cell Lung Cancer. J Thorac Oncol. 2018;13(5):699-706. doi: 610.1016/j.jtho.2018.1002.1015. Epub 2018 Mar 1012.
    22. Ferro A, Morais S, Rota M, et al. Tobacco smoking and gastric cancer: meta-analyses of published data versus pooled analyses of individual participant data (StoP Project). Eur J Cancer Prev. 2018;27(3):197-204. doi: 110.1097/CEJ.0000000000000401.
    23. Ghoussaini M, Edwards SL, Michailidou K, et al. Publisher Correction: Evidence that breast cancer risk at the 2q35 locus is mediated through IGFBP5 regulation. Nat Commun. 2018;9:16193.(doi):10.1038/ncomms16193.
    24. Hiwa R, Ikari K, Ohmura K, et al. HLA-DRB1 Analysis Identified a Genetically Unique Subset within Rheumatoid Arthritis and Distinct Genetic Background of Rheumatoid Factor Levels from Anticyclic Citrullinated Peptide Antibodies. J Rheumatol. 2018;45(4):470-480. doi: 410.3899/jrheum.170363. Epub 172018 Feb 170361.
    25. Ugai T, Matsuo K, Sawada N, et al. Coffee and green tea consumption and subsequent risk of acute myeloid leukemia and myelodysplastic syndromes in Japan. Int J Cancer. 2018;142(6):1130-1138. doi: 1110.1002/ijc.31135. Epub 32017 Nov 31121.
    26. Praud D, Rota M, Pelucchi C, et al. Cigarette smoking and gastric cancer in the Stomach Cancer Pooling (StoP) Project. Eur J Cancer Prev. 2018;27(2):124-133. doi: 110.1097/CEJ.0000000000000290.
    27. Lu Y, Sobue T, Kitamura T, et al. Cigarette smoking, alcohol drinking, and oral cavity and pharyngeal cancer in the Japanese: a population-based cohort study in Japan. Eur J Cancer Prev. 2018;27(2):171-179. doi: 110.1097/CEJ.0000000000000283.
    28. Inoue S, Hosono S, Ito H, et al. Improvement in 5-Year Relative Survival in Cancer of the Corpus Uteri From 1993-2000 to 2001-2006 in Japan. J Epidemiol. 2018;28(2):75-80. doi: 10.2188/jea.JE20170008. Epub 20172017 Nov 20170004.
    29. Ugai T, Matsuo K, Oze I, et al. Smoking and subsequent risk of acute myeloid leukaemia: A pooled analysis of 9 cohort studies in Japan. Hematol Oncol. 2018;36(1):262-268. doi: 210.1002/hon.2457. Epub 2017 Jul 1006.
    30. Ugai T, Kelemen LE, Mizuno M, et al. Ovarian cancer risk, ALDH2 polymorphism and alcohol drinking: Asian data from the Ovarian Cancer Association Consortium. Cancer Sci. 2018;109(2):435-445. doi: 410.1111/cas.13470. Epub 12018 Jan 13421.
    31. Kawaguchi T, Shima T, Mizuno M, et al. Risk estimation model for nonalcoholic fatty liver disease in the Japanese using multiple genetic markers. PLoS One. 2018;13(1):e0185490. doi: 0185410.0181371/journal.pone.0185490. eCollection 0182018.
    32. Nakagawa-Senda H, Hachiya T, Shimizu A, et al. A genome-wide association study in the Japanese population identifies the 12q24 locus for habitual coffee consumption: The J-MICC Study. Sci Rep. 2018;8(1):1493. doi: 1410.1038/s41598-41018-19914-w.
    33. Urayama KY, Takagi M, Kawaguchi T, et al. Regional evaluation of childhood acute lymphoblastic leukemia genetic susceptibility loci among Japanese. Sci Rep. 2018;8(1):789. doi: 710.1038/s41598-41017-19127-41597.
    34. Campa D, Pastore M, Capurso G, et al. Do pancreatic cancer and chronic pancreatitis share the same genetic risk factors? A PANcreatic Disease ReseArch (PANDoRA) consortium investigation. Int J Cancer. 2018;142(2):290-296. doi: 210.1002/ijc.31047. Epub 32017 Oct 31016.
    35. Aoki K, Nakamura H, Suzuki H, et al. Prognostic relevance of genetic alterations in diffuse lower-grade gliomas. Neuro Oncol. 2018;20(1):66-77. doi: 10.1093/neuonc/nox1132.
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    37. Iso H, Matsuo K, Katanoda K, Fujiwara T. New Policy of the Journal of Epidemiology Regarding the Relationship With the Tobacco Industry. J Epidemiol. 2018;28(1):1-2. doi: 10.2188/jea.JE20170187. Epub 20172017 Oct 20170125.
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  • 2017年
    1. Masaoka H, Matsuo K, Sawada N, et al. Alcohol consumption and bladder cancer risk with or without the flushing response: The Japan Public Health Center-based Prospective Study. Int J Cancer. 2017;141(12):2480-2488. doi: 2410.1002/ijc.31028. Epub 32017 Sep 31015.
    2. Abe M, Ito H, Oze I, Nomura M, Ogawa Y, Matsuo K. The more from East-Asian, the better: risk prediction of colorectal cancer risk by GWAS-identified SNPs among Japanese. J Cancer Res Clin Oncol. 2017;143(12):2481-2492. doi: 2410.1007/s00432-00017-02505-00434. Epub 02017 Aug 00428.
    3. Maeda Y, Nishimori H, Yoshida I, et al. Dose-adjusted EPOCH chemotherapy for untreated peripheral T-cell lymphomas: a multicenter phase II trial of West-JHOG PTCL0707. Haematologica. 2017;102(12):2097-2103. doi: 2010.3324/haematol.2017.167742. Epub 162017 Sep 167729.
    4. Niibe Y, Onda T, Matsuo K, Inoue Y, Hayakawa K. Phase II Study of Concurrent Chemoradiotheapy Using Nedaplatin for Locally Advanced Uterine Cervical Carcinoma (KGROG0501): Final Results. Anticancer Res. 2017;37(12):6983-6988. doi: 6910.21873/anticanres.12166.
    5. Terao C, Okada Y, Ikari K, et al. Genetic landscape of interactive effects of HLA-DRB1 alleles on susceptibility to ACPA(+) rheumatoid arthritis and ACPA levels in Japanese population. J Med Genet. 2017;54(12):853-858. doi: 810.1136/jmedgenet-2017-104779. Epub 102017 Oct 104712.
    6. Milne RL, Kuchenbaecker KB, Michailidou K, et al. Identification of ten variants associated with risk of estrogen-receptor- negative breast cancer. Nat Genet. 2017;49(12):1767-1778. doi: 1710.1038/ng.3785. Epub 2017 Oct 1723.
    7. Saito E, Inoue M, Tsugane S, et al. Smoking cessation and subsequent risk of cancer: A pooled analysis of eight population-based cohort studies in Japan. Cancer Epidemiol. 2017;51:98-108.(doi):10.1016/j.canep.2017.1010.1013. Epub 2017 Nov 1015.
    8. Rota M, Pelucchi C, Bertuccio P, et al. Alcohol consumption and gastric cancer risk-A pooled analysis within the StoP project consortium. Int J Cancer. 2017;141(10):1950-1962. doi: 1910.1002/ijc.30891. Epub 32017 Aug 30898.
    9. Brouckaert O, Rudolph A, Laenen A, et al. Reproductive profiles and risk of breast cancer subtypes: a multi-center case-only study. Breast Cancer Res. 2017;19(1):119. doi: 110.1186/s13058-13017-10909-13053.
    10. Michailidou K, Lindstrom S, Dennis J, et al. Association analysis identifies 65 new breast cancer risk loci. Nature. 2017;551(7678):92-94. doi: 10.1038/nature24284. Epub 22017 Oct 24223.
    11. Kawakita D, Lee YA, Turati F, et al. Dietary fiber intake and head and neck cancer risk: A pooled analysis in the International Head and Neck Cancer Epidemiology consortium. Int J Cancer. 2017;141(9):1811-1821. doi: 1810.1002/ijc.30886. Epub 32017 Jul 30827.
    12. Minlikeeva AN, Freudenheim JL, Cannioto RA, et al. History of thyroid disease and survival of ovarian cancer patients: results from the Ovarian Cancer Association Consortium, a brief report. Br J Cancer. 2017;117(7):1063-1069. doi: 1010.1038/bjc.2017.1267. Epub 2017 Aug 1017.
    13. Kawakita D, Matsuo K. Alcohol and head and neck cancer. Cancer Metastasis Rev. 2017;36(3):425-434. doi: 410.1007/s10555-10017-19690-10550.
    14. Minlikeeva AN, Freudenheim JL, Eng KH, et al. History of Comorbidities and Survival of Ovarian Cancer Patients, Results from the Ovarian Cancer Association Consortium. Cancer Epidemiol Biomarkers Prev. 2017;26(9):1470-1473. doi: 1410.1158/1055-9965.EPI-1417-0367.
    15. Masaoka H, Gallus S, Ito H, et al. Aldehyde Dehydrogenase 2 Polymorphism Is a Predictor of Smoking Cessation. Nicotine Tob Res. 2017;19(9):1087-1094. doi: 1010.1093/ntr/ntw1316.
    16. Ugai T, Matsuo K, Sawada N, et al. Smoking and alcohol and subsequent risk of myelodysplastic syndromes in Japan: the Japan Public Health Centre-based Prospective Study. Br J Haematol. 2017;178(5):747-755. doi: 710.1111/bjh.14749. Epub 12017 Jul 14717.
    17. Hijioka S, Hosoda W, Matsuo K, et al. Rb Loss and KRAS Mutation Are Predictors of the Response to Platinum- Based Chemotherapy in Pancreatic Neuroendocrine Neoplasm with Grade 3: A Japanese Multicenter Pancreatic NEN-G3 Study. Clin Cancer Res. 2017;23(16):4625-4632. doi: 4610.1158/1078-0432.CCR-4616-3135. Epub 2017 Apr 4628.
    18. Masaoka H, Ito H, Yokomizo A, Eto M, Matsuo K. Potential overtreatment among men aged 80 years and older with localized prostate cancer in Japan. Cancer Sci. 2017;108(8):1673-1680. doi: 1610.1111/cas.13293. Epub 12017 Jul 13294.
    19. Ugai T, Kanda Y, Morishima Y, Matsuo K. Role of Genetic Polymorphism of ALDH2 in Hematopoietic Stem Cell Transplantation. Biol Blood Marrow Transplant. 2017;23(8):1374-1380. doi: 1310.1016/j.bbmt.2017.1303.1033. Epub 2017 Apr 1374.
    20. Ugai T, Matsuo K, Sawada N, et al. Coffee and Green Tea Consumption and Subsequent Risk of Malignant Lymphoma and Multiple Myeloma in Japan: The Japan Public Health Center- based Prospective Study. Cancer Epidemiol Biomarkers Prev. 2017;26(8):1352-1356. doi: 1310.1158/1055-9965.EPI-1317-0231.
    21. Nakagawa-Senda H, Ito H, Hosono S, Oze I, Tanaka H, Matsuo K. Coffee consumption and the risk of colorectal cancer by anatomical subsite in Japan: Results from the HERPACC studies. Int J Cancer. 2017;141(2):298-308. doi: 210.1002/ijc.30746. Epub 32017 May 30748.
    22. Ugai T, Matsuo K, Sawada N, et al. Smoking and subsequent risk of leukemia in Japan: The Japan Public Health Center-based Prospective Study. J Epidemiol. 2017;27(7):305-310. doi: 310.1016/j.je.2016.1007.1005. Epub 2017 Apr 1018.
    23. Soh SX, Siddiqui FJ, Allen JC, et al. A systematic review and meta-analysis of individual patient data on the impact of the BIM deletion polymorphism on treatment outcomes in epidermal growth factor receptor mutant lung cancer. Oncotarget. 2017;8(25):41474-41486. doi: 41410.18632/oncotarget.17102.
    24. Chen Y, Wu F, Saito E, et al. Association between type 2 diabetes and risk of cancer mortality: a pooled analysis of over 771,000 individuals in the Asia Cohort Consortium. Diabetologia. 2017;60(6):1022-1032. doi: 1010.1007/s00125-00017-04229-z. Epub 02017 Mar 00127.
    25. Miura K, Hirakawa H, Uemura H, et al. Sentinel node biopsy for oral cancer: A prospective multicenter Phase II trial. Auris Nasus Larynx. 2017;44(3):319-326. doi: 310.1016/j.anl.2016.1007.1008. Epub 2016 Aug 1013.
    26. Praestegaard C, Jensen A, Jensen SM, et al. Cigarette smoking is associated with adverse survival among women with ovarian cancer: Results from a pooled analysis of 19 studies. Int J Cancer. 2017;140(11):2422-2435. doi: 2410.1002/ijc.30600. Epub 32017 Jan 30624.
    27. Shimelis H, Mesman RLS, Von Nicolai C, et al. BRCA2 Hypomorphic Missense Variants Confer Moderate Risks of Breast Cancer. Cancer Res. 2017;77(11):2789-2799. doi: 2710.1158/0008-5472.CAN-2716-2568. Epub 2017 Mar 2710.
    28. Minlikeeva AN, Freudenheim JL, Cannioto RA, et al. History of hypertension, heart disease, and diabetes and ovarian cancer patient survival: evidence from the ovarian cancer association consortium. Cancer Causes Control. 2017;28(5):469-486. doi: 410.1007/s10552-10017-10867-10551. Epub 12017 Mar 10514.
    29. Fehringer G, Brenner DR, Zhang ZF, et al. Alcohol and lung cancer risk among never smokers: A pooled analysis from the international lung cancer consortium and the SYNERGY study. Int J Cancer. 2017;140(9):1976-1984. doi: 1910.1002/ijc.30618. Epub 32017 Feb 30627.
    30. Babic A, Cramer DW, Kelemen LE, et al. Predictors of pretreatment CA125 at ovarian cancer diagnosis: a pooled analysis in the Ovarian Cancer Association Consortium. Cancer Causes Control. 2017;28(5):459-468. doi: 410.1007/s10552-10016-10841-10553. Epub 12017 Jan 10553.
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    32. Yoshizato T, Nannya Y, Atsuta Y, et al. Genetic abnormalities in myelodysplasia and secondary acute myeloid leukemia: impact on outcome of stem cell transplantation. Blood. 2017;129(17):2347-2358. doi: 2310.1182/blood-2016-2312-754796. Epub 752017 Feb 754721.
    33. Takachi R, Inoue M, Sugawara Y, et al. Fruit and vegetable intake and the risk of overall cancer in Japanese: A pooled analysis of population-based cohort studies. J Epidemiol. 2017;27(4):152-162. doi: 110.1016/j.je.2016.1005.1004. Epub 2017 Jan 1015.
    34. Okumura N, Sonobe M, Okabe K, et al. Feasibility of adjuvant chemotherapy with S-1 plus carboplatin followed by single-agent maintenance therapy with S-1 for completely resected non- small-cell lung cancer: results of the Setouchi Lung Cancer Group Study 1001. Int J Clin Oncol. 2017;22(2):274-282. doi: 210.1007/s10147-10016-11067-10149. Epub 12016 Dec 10145.
    35. Fujisawa S, Mizuta S, Akiyama H, et al. Phase II study of imatinib-based chemotherapy for newly diagnosed BCR- ABL-positive acute lymphoblastic leukemia. Am J Hematol. 2017;92(4):367-374. doi: 310.1002/ajh.24653. Epub 22017 Feb 24621.
    36. Masaoka H, Ito H, Gallus S, et al. Combination of ALDH2 and ADH1B polymorphisms is associated with smoking initiation: A large-scale cross-sectional study in a Japanese population. Drug Alcohol Depend. 2017;173:85-91.(doi):10.1016/j.drugalcdep.2016.1012.1015. Epub 2017 Feb 1011.
    37. Hori H, Kudoh T, Nishimura S, et al. Acute and late toxicities of pirarubicin in the treatment of childhood acute lymphoblastic leukemia: results from a clinical trial by the Japan Association of Childhood Leukemia Study. Int J Clin Oncol. 2017;22(2):387-396. doi: 310.1007/s10147-10016-11062-10141. Epub 12016 Nov 10117.
    38. Horibe K, Yumura-Yagi K, Kudoh T, et al. Long-term Results of the Risk-adapted Treatment for Childhood B-Cell Acute Lymphoblastic Leukemia: Report From the Japan Association of Childhood Leukemia Study ALL-97 Trial. J Pediatr Hematol Oncol. 2017;39(2):81-89. doi: 10.1097/MPH.0000000000000760.
    39. Oze I, Shimada S, Nagasaki H, et al. Plasma microRNA-103, microRNA-107, and microRNA-194 levels are not biomarkers for human diffuse gastric cancer. J Cancer Res Clin Oncol. 2017;143(3):551-554. doi: 510.1007/s00432-00016-02316-z. Epub 02016 Dec 00431.
    40. Sawabe M, Ito H, Oze I, et al. Heterogeneous impact of alcohol consumption according to treatment method on survival in head and neck cancer: A prospective study. Cancer Sci. 2017;108(1):91-100. doi: 110.1111/cas.13115. Epub 12017 Jan 13126.
    41. Seow WJ, Matsuo K, Hsiung CA, et al. Association between GWAS-identified lung adenocarcinoma susceptibility loci and EGFR mutations in never-smoking Asian women, and comparison with findings from Western populations. Hum Mol Genet. 2017;26(2):454-465. doi: 410.1093/hmg/ddw1414.
    42. Koyanagi YN, Ito H, Oze I, et al. Development of a prediction model and estimation of cumulative risk for upper aerodigestive tract cancer on the basis of the aldehyde dehydrogenase 2 genotype and alcohol consumption in a Japanese population. Eur J Cancer Prev. 2017;26(1):38-47. doi: 10.1097/CEJ.0000000000000222.
    43. Matsuo K. Message from the new Editor-in-Chief. J Epidemiol. 2017;27(1):1. doi: 10.1016/j.je.2016.1010.1001. Epub 2016 Dec 1021.
    44. Takenaka K, Shimoda K, Uchida N, et al. Clinical features and outcomes of patients with primary myelofibrosis in Japan: report of a 17-year nationwide survey by the Idiopathic Disorders of Hematopoietic Organs Research Committee of Japan. Int J Hematol. 2017;105(1):59-69. doi: 10.1007/s12185-12016-12102-12183. Epub 12016 Oct 12119.
  • 2016年
    1. Shi J, Park JH, Duan J, et al. Winner's Curse Correction and Variable Thresholding Improve Performance of Polygenic Risk Modeling Based on Genome-Wide Association Study Summary-Level Data. PLoS Genet. 2016;12(12):e1006493. doi: 1006410.1001371/journal.pgen.1006493. eCollection 1002016 Dec.
    2. Wen W, Shu XO, Guo X, et al. Prediction of breast cancer risk based on common genetic variants in women of East Asian ancestry. Breast Cancer Res. 2016;18(1):124. doi: 110.1186/s13058-13016-10786-13051.
    3. Liu J, Loncar I, Collee JM, et al. rs2735383, located at a microRNA binding site in the 3'UTR of NBS1, is not associated with breast cancer risk. Sci Rep. 2016;6:36874.(doi):10.1038/srep36874.
    4. Takahara T, Matsuo K, Seto M, Nakamura S, Tsuzuki S. Synergistic activity of Card11 mutant and Bcl6 in the development of diffuse large B-cell lymphoma in a mouse model. Cancer Sci. 2016;107(11):1572-1580. doi: 1510.1111/cas.13057. Epub 12016 Nov 13054.
    5. Yabe M, Yabe H, Morimoto T, et al. The phenotype and clinical course of Japanese Fanconi Anaemia infants is influenced by patient, but not maternal ALDH2 genotype. Br J Haematol. 2016;175(3):457-461. doi: 410.1111/bjh.14243. Epub 12016 Jul 14245.
    6. Hosono S, Ito H, Oze I, et al. A risk prediction model for colorectal cancer using genome-wide association study-identified polymorphisms and established risk factors among Japanese: results from two independent case-control studies. Eur J Cancer Prev. 2016;25(6):500-507. doi: 510.1097/CEJ.0000000000000213.
    7. Hampras SS, Sucheston-Campbell LE, Cannioto R, et al. Assessment of variation in immunosuppressive pathway genes reveals TGFBR2 to be associated with risk of clear cell ovarian cancer. Oncotarget. 2016;7(43):69097-69110. doi: 69010.18632/oncotarget.10215.
    8. Ghoussaini M, French JD, Michailidou K, et al. Evidence that the 5p12 Variant rs10941679 Confers Susceptibility to Estrogen-Receptor-Positive Breast Cancer through FGF10 and MRPS30 Regulation. Am J Hum Genet. 2016;99(4):903-911. doi: 910.1016/j.ajhg.2016.1007.1017. Epub 2016 Sep 1015.
    9. Asano T, Natsume S, Senda Y, et al. Incidence and risk factors for anastomotic stenosis of continuous hepaticojejunostomy after pancreaticoduodenectomy. J Hepatobiliary Pancreat Sci. 2016;23(10):628-635. doi: 610.1002/jhbp.1385. Epub 2016 Aug 1029.
    10. Shi J, Zhang Y, Zheng W, et al. Fine-scale mapping of 8q24 locus identifies multiple independent risk variants for breast cancer. Int J Cancer. 2016;139(6):1303-1317. doi: 1310.1002/ijc.30150. Epub 32016 Jun 30117.
    11. Darabi H, Beesley J, Droit A, et al. Fine scale mapping of the 17q22 breast cancer locus using dense SNPs, genotyped within the Collaborative Oncological Gene-Environment Study (COGs). Sci Rep. 2016;6:32512.(doi):10.1038/srep32512.
    12. Lawrenson K, Kar S, Mccue K, et al. Functional mechanisms underlying pleiotropic risk alleles at the 19p13.1 breast-ovarian cancer susceptibility locus. Nat Commun. 2016;7:12675.(doi):10.1038/ncomms12675.
    13. Kar SP, Beesley J, Amin Al Olama A, et al. Genome-Wide Meta-Analyses of Breast, Ovarian, and Prostate Cancer Association Studies Identify Multiple New Susceptibility Loci Shared by at Least Two Cancer Types. Cancer Discov. 2016;6(9):1052-1067. doi: 1010.1158/2159-8290.CD-1015-1227. Epub 2016 Jul 1017.
    14. Uchino K, Mizuno S, Mizutani M, et al. Toll-like receptor 1 variation increases the risk of transplant-related mortality in hematologic malignancies. Transpl Immunol. 2016;38:60-6.(doi):10.1016/j.trim.2016.1006.1002. Epub 2016 Jun 1028.
    15. Wyszynski A, Hong CC, Lam K, et al. An intergenic risk locus containing an enhancer deletion in 2q35 modulates breast cancer risk by deregulating IGFBP5 expression. Hum Mol Genet. 2016;25(17):3863-3876. doi: 3810.1093/hmg/ddw3223. Epub 2016 Jul 3811.
    16. Campa D, Pastore M, Gentiluomo M, et al. Functional single nucleotide polymorphisms within the cyclin-dependent kinase inhibitor 2A/2B region affect pancreatic cancer risk. Oncotarget. 2016;7(35):57011-57020. doi: 57010.18632/oncotarget.10935.
    17. Horne HN, Chung CC, Zhang H, et al. Fine-Mapping of the 1p11.2 Breast Cancer Susceptibility Locus. PLoS One. 2016;11(8):e0160316. doi: 0160310.0161371/journal.pone.0160316. eCollection 0162016.
    18. Kakiuchi T, Takahara T, Kasugai Y, et al. Modeling mesothelioma utilizing human mesothelial cells reveals involvement of phospholipase-C beta 4 in YAP-active mesothelioma cell proliferation. Carcinogenesis. 2016;24(10).
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    20. Hidaka A, Sasazuki S, Matsuo K, et al. CYP1A1, GSTM1 and GSTT1 genetic polymorphisms and gastric cancer risk among Japanese: A nested case-control study within a large-scale population-based prospective study. Int J Cancer. 2016;139(4):759-768. doi: 710.1002/ijc.30130. Epub 32016 Apr 30126.
    21. Shiraishi K, Okada Y, Takahashi A, et al. Association of variations in HLA class II and other loci with susceptibility to EGFR-mutated lung adenocarcinoma. Nat Commun. 2016;7:12451.(doi):10.1038/ncomms12451.
    22. Han MR, Long J, Choi JY, et al. Genome-wide association study in East Asians identifies two novel breast cancer susceptibility loci. Hum Mol Genet. 2016;25(15):3361-3371. doi: 3310.1093/hmg/ddw3164. Epub 2016 Jun 3327.
    23. Kasugai Y, Yoshida N, Ohshima K, Matsuo K, Seto M, Tsuzuki S. New mouse model of acute adult T-cell leukemia generated by transplantation of AKT, BCLxL, and HBZ-transduced T cells. Cancer Sci. 2016;107(8):1072-1078. doi: 1010.1111/cas.12974. Epub 12016 Jun 12922.
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研究キーワード

疫学、がん、分子疫学、臨床疫学、分析疫学

愛知県がんセンター研究所　がん予防研究分野 ホームページ

その他

我々と愛知県がんセンターで、がんの疫学研究をする大学院生を募集しています。大学院生時代に研究に集中できる体制が整っています。また、英文論文発表は当然ながら、国内外における学会発表、研修の支援も行っています。