Introduction

Our department is treating all sorts of digestive diseases based on the top-level knowledge and technology in Japan. Our team consists of four groups, Upper GI, Lower GI, Pancreaticobiliary and Hepatology. In the clinical field, Upper GI, Lower GI and Pancreaticobiliary groups are mainly dealing with the introduction and development of new endoscopic diagnosis and treatment, and Hepatology group is working on the novel treatment of viral hepatitis, liver cirrhosis and liver cancer. In the research field, in addition to the study of each group, we are working on the study of nutrition and gut microbiome from the standpoint of multi-organ including pancreas and liver, not only the small intestine and colon. As described above, in our department young doctors are proactively working on development of the tradition or newly established research from both clinical and basic aspects. Moreover, as part of globalization, we have been making a contribution as a national project by establishing endoscopy training centers for the improvement of endoscopic techniques in the Mekong region countries (Vietnam, Laos, Cambodia, Thailand and Myanmar) since 2012. We have also proactively engaged in the joint research with foreign countries.

Research Projects

①Upper GI Group

1）Molecular biological research on GISTs.
By analyzing not only well-known gene mutation but also micro-array method, we are studying molecular biological research in order to clarify the mechanism of GIST which are related to malignancy and prognosis.

2）Invasion depth diagnosis of upper gastrointestinal tract tumors using the ultra-high-frequency ultrasound miniature probe
In our department, we research by using the ultra-high-frequency ultrasound miniature probe (hereinafter referred to as the ultra-high-frequency probe) that is developed newly. Ultrasound become more high frequency, more high resolution. So it is expected that the new probe may diagnose depth invasion easily and exactly for early stage gastrointestinal cancer (esophageal cancer, gastric cancer, colon cancer , etc.) confined to the gastrointestinal tract surface compared with conventional ultrasound miniature probe which frequency is 5-20MHz. On this study, we compare the image which is visualized by using the new probe the endoscopic resection or surgical resection specimens of the upper gastrointestinal tract tumors to pathological findings for examining the possibility of invasion depth diagnostic accuracy and clinical application by the ultra-high-frequency probe.

3）Correlation between upper gastrointestinal disease and gut microbiota
We have analyzed about correlation between upper gastrointestinal disease and gut microbiota. Among them, we are especilally researching the change of gut microbiota in eradication of H. pylori.

4）Feasibility study of endoscopic all-in-focus image creation and analysis in the gastrointestinal tract.
The aim of this study is the development of the technique to enable the generation of all focus images that is correct in all for the observation and to overcome a drop of the diagnosis ability due to shallowness of focus in the endoscopy as part of medical-engineering collaboration, and to evaluate the feasibility of endoscopic all-in-focus image in clinical practice.

5）EUS-guided forceps biopsy from upper GI subepithelial lesions using　a forward-viewing echoendoscope
The aim of this study is to evaluate the feasibility of endoscopic ultrasound-guided forceps biopsy (EUS-FB) from upper gastrointestinal subepithelial lesions using a forward-viewing echoendoscope.

6）Development of CAD system for gastrointestinal disease
We are developing computer-aided detection and diagnosis (CAD) systems for medical imagings of gastrointestinal disease.

②. Lower GI Group

1）Evaluation of gastrointestinal biomarkers using biopsy specimen
Frequency and distribution of biomarkers, such as Niemann-Pick C1-Like 1, in the gastrointestinal tract are evaluated and we would like to reveal the features of gastrointestinal diseases.

2）The usefulness of Carbon dioxide insufflation for endoscopic retrograde cholangiopancreatography using double-balloon endoscopy in patients with altered GI anatomy.
This study evaluates the usefulness of Carbon dioxide insufflation for endoscopic retrogradecholangiopancreatography using double-balloon endoscopy in patients with altered GI anatomy.

3）Differential diagnosis between sporadic and colitis-associated neoplasm in patients with ulcerative colitis
Sporadic colorectal cancer (sCRC) develops in patients with ulcerative colitis (UC) as well as colitis-associated colorectal cancer (CAC). It is important to differentiate between sCRC and CAC. It is because accurate diagnosis determines surgical procedure.

4）Evaluation of the efficacy and safety with Dexmedetomidine in double-balloon endoscopy
Patients who received double-balloon endoscopy (DBE) need sedatives, however DBEs areoften hampered by body motions or cardiopulmonary depression. Dexmedetomidine (DEX) has less respiratory depression effect and suppressive effect of body motion. In this study, we evaluate the efficacy and safety of sedation with DEX in DBE

5）A prospective validation study for the Obscure Gastrointestinal Bleeding Score to predict the usefulness of double-balloon endoscopy in patients with obscure gastrointestinal bleeding
The purpose of this study is to build a new scoring system that predicts the necessity of double-balloon endoscopy in patients with OGIB. This scoring system consists of clinical profiles, laboratory data and capsule endoscopic findings. We also verify practical effectiveness of this scoring system prospectively in other patients with OGIB.

6）Evaluation of insertability of endoscope in the examination of colonoscopy
The performance of endoscope has been improved, but it is difficult to insert colonoscope in some cases. We evaluate the factors that are related to insertability in the examination ofcolonoscopy.

7) The explorative study on the relationship between the findings of double-balloon endoscopy and the levels of fecal markers in Crohn's disease
We make a measurement of fecal calprotectin in patients with Crohn's disease who take double-balloon endoscopy and evaluate the relationship between the findings of endoscopy and the scores of fecal calprotectin.

8）The observational study on clinical application of the stromal forming protein for tumor stromal marker
We evaluate the stromal forming protein in human blood serum or tumor stroma.

9）A randomized trial of evaluation for the usefulness of cold polypectomy compared to conventional polypectomy for colorectal polyps
It is reported that cold polypectomy needs the shorter procedure time and has the lower frequency of adverse events such as delayed bleeding and perforation than conventional polypectomy. But this procedure has not been widely used in Japan. This is the prospective randomized controlled study to compare the safety and effectiveness of cold polypectomy with conventional polypectomy.

Cold polypectomy technique
A. A small colorectal polyp(<10mm) suspected of adenoma
B. Resection by cold snare polypectomy without coagulation
C Hemostasis is not often necessary because early bleeding after cold polypectomy stops soon.

③Pnacreato-Biliary Group

1）Developing new diagnostic method for bilio-pancreatic lesions to use several applications and software of ultrasonography.
We try to discover a new imaging diagnostic method using transabdominal ultrasonography (US) and endoscopic ultrasonography (EUS). And we also search new biomarkers using cytological and histological specimen taken by EUS-FNA or ERCP.

2）Combination of immunotherapy and chemotherapy for unresectable locally advanced pancreatic cancer patients.
The aim of this study is to assess the safety and observation of tumor control effect using the chemotherapy combination with immune cell therapy using EUS-FNA as a primary treatment.

3）Combination of immunotherapy and chemotherapy for unresectable locally advanced pancreatic cancer patients.
The aim of this study is to assess the safety and observation of tumor control effect using the chemotherapy combination with immune cell therapy using EUS-FNA as a 　primary treatment.

4）Endoscopic diagnosis and treatment of Ampullary tumor
Our aims are how to diagnose ampullary tumor using ERCP technique and intra-ductal ultrasonography and how to perform less invasive endoscopic ampullectomy.

5）Trans-papillary diagnosis and treatment of biliary disease
More precise and less invasive diagnosis of biliary disease using intra-ductal ultrasonography, trans-papillary forceps biopsy and so on. And how to less invasive and more suitable treatment of biliary stricture (malignancy and benign) and CBD stones.

6）Multicenter prospective observatory study for pancreatic cystic lesion.
Our aim of this study is to elucidate the natural history of pancreatic cystic lesions especially intraductal papillary mucinous neoplasms (IPMN).

7）Diagnosis, treatment, and natural history studies of autoimmune pacreatitis
We are analyzing pancreatic tissues of autoimmune pancreatitis (AIP) collected by EUS-guided FNA (EUS-FNA) biopsy in Nagoya University Hospital and Nagoya University-affiliated institutions and researching usefulness of EUS-FNA for a diagnosis of AIP which is less invasive and safe histologic diagnostic method.

Histopathology of lymphoplasmacytic sclerosing pancreatitis.
A, H&E staining of tissue obtained by EUS-guided FNA biopsy .
B, The findings demonstrate replacement of the acinar structure by lymphoplasmacytic infiltration and fibrosis .
C, Abundant immunoglobulin G4–positive cells are found in the high-power field .

EUS-FNA biopsy for AIP

8）Development of a Sensitive Method Detecting Pancreatic Fibrosis
We are developing a sensitive method to detect pancreatic fibrosis in order to obtain early diagnosis of chronic pancreatitis which is irreversible and progressive. This work is supported in part by the Research Committee of Intractable Pancreatic Diseases in Japan, provided by the Ministry of Health, Labour and Welfare of Japan. In addition to Endoscopic Ultrasound, the usefulness of measuring tissue elasticity using Transabdominal Ultrasound or MRI, new tests for pancreatic exocrine function and serum marker have been investigated. Strain elastography 　　　 Shear wave elastography (Endoscopic Ultrasound) (Transabdominal Ultrasound)

Strain elastography (Endoscopic Ultrasound)	Shear wave elastography (Transabdominal Ultrasound)

9）Exploratory study of nutritional status influenced by correlation between pancreas and small intestine using a newly developed enteroscopy. Exploratory study of correlation between gut microbiota and digestive diseases.
Using newly developed enteroscopy, it’s now possible to observe small intestine safely with less patient’s pain. In order to clarify the nutritional status influenced by correlation between pancreatic function and small intestine, morphology and function of jejunum villous mucosa are evaluated in patients with pancreatic diseases. We are also analyzing gut microbiota of patients with digestive disease, using next-generation sequencer.

10）A study on the usefulness of the prototype small-diameter high-frequency ultrasonic probe
Intraductal-ultrasonography (IDUS) by the 20MHz ultrasound probe is conducted to diagnose for the pancreatobiliary diseases. Now we try more detailed examination using further high-frequency ultrasonic probe for the surgical specimen.

11）Evaluation of EGJ (esophagogastric junction) function using elastography
Elastography which can evaluate to measure hardness is one of the ultrasonic diagnostic technology. We have studied the usefulness of evaluation of EGJ function to measure changes in hardness using elastography.

④Hepatology Group

1. Research for pathophysiological mechanisms of viral hepatitis
i) Hepatitis C Virus (HCV): Multicenter studies of interferon (IFN)-based and IFN-free, combination of direct acting antivirals (DAAs) were conducted and investigated the efficacy, safety, and exploratory investigation for the factors associated with treatment response. Among these studies, correlation with host IL28B gene polymorphism, amino acid substitution in HCV core, NS5A lesions and treatment response of IFN-based regimen have been already reported. These analysis is also on the way in IFN-free treatment, and we also investigated the dynamics of immune reaction after viral eradication by treatment.
ii) Hepatitis B virus (HBV) Life cycle of HBV is more complicated compared with HCV, so the development of curative treatment against HBV is considered to be difficult. In liver unit, correlation between HBsAg dispperance, which is considered as clinical remission, and the viral mutation in HBV core lesion, and in patients with serum negativity of HBV-DNA by nucleos(t)ide analogues, which are standard regimens in HBV patients, correlations between serum HBV markers (HBsAg, HB core related antigen) and pathophysiology, and exploration of factors associated with hepaticarcinogenesis are now ongoing.....

2. Analysis for new treatment against hepatocellular carcinoma (HCC)
For the investigation of new treatment against hepatocellular carcinoma, efficacy and safety of new devices for radiofrequency ablation (RFA), prospective study for the standardization of transcatheter arterial chemoembolization (TACE), and the efficacy and safety of sorafenib for patients with advanced HCC and exploratory study for the factors associated with the treatment effect of sorafenib as multicenter study are done. 3. Correlation between inflammatory response and liver regeneration in animal model for acute liver failure There are no established treatment for promoting liver regeneration, effect of stem cells from human exfoliated deciduous teeth (SHED) as one of the most promising tool for this purpose was investigated as the collaboration with department of maxillofacial surgery. And the factors with strong effect were identified in the supernatant of culture of SHED, and investigated the efficacy and safety of these factors and whether strong anti-inflammation is essential for liver regeneration.

Faculty Members

Faculty	Position	Department
Hiroki Kawashima	Professor	Department of Gastroenterology & Hepatology
Masatoshi Ishigami	Associate professor	Department of Gastroenterology & Hepatology
Takashi Honda	Lecturer	Department of Gastroenterology & Hepatology
Masanao Nakamura	Lecturer	Department of Gastroenterology & Hepatology
Eizaburo Ohno	Lecturer	Department of Gastroenterology & Hepatology
Kazuhiro Furukawa	Lecturer	Department of Gastroenterology & Hepatology
Takuya Ishikawa	Assistant Professor	Department of Gastroenterology & Hepatology
Yoji Ishizu	Assistant Professor	Department of Gastroenterology & Hepatology
Takeshi Yamamura	Assistant Professor	Department of Gastroenterology & Hepatology
Keiko Maeda	Assistant Professor	Department of Gastroenterology & Hepatology
Norihiro Imai	Assistant Professor	Department of Gastroenterology & Hepatology
Takanori Ito	Assistant Professor	Department of Gastroenterology & Hepatology
Kentaro Yamao	Assistant Professor	Department of Gastroenterology & Hepatology
Tsunaki Sawada	Assistant Professor	Department of Gastroenterology & Hepatology
Taku Tanaka	Assistant Professor	Emergency and Critical Care Medicine
Yasuyuki Mizutani	Assistant Professor	Department of Gastroenterology & Hepatology
Eri Ishikawa	Assistant Professor	Department of Gastroenterology & Hepatology
Kenta Yamamoto	Assistant Professor	Department of Gastroenterology & Hepatology
Shinya Yokoyama	Assistant Professor	Department of Gastroenterology & Hepatology
Tadashi Iida	Assistant Professor	Department of Gastroenterology & Hepatology

Bibliography

• 2021

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  14. Yamada K, Nakamura M, Yamamura T, Maeda K, Sawada T, Mizutani Y, Ishikawa E, Ishikawa T, Kakushima N, Furukawa K, Ohno E, Kawashima H, Honda T, Ishigami M, Fujishiro M. Diagnostic yield of colon capsule endoscopy for Crohn's disease lesions in the whole gastrointestinal tract BMC Gastroenterol 10.1186/s12876-021-01657-0
  15. Esaki M, Yamamura T, Nakamura M, Maeda K, Sawada T, Mizutani Y, Ishikawa E, Furukawa K, Kawashima H, Hirooka Y, Fujishiro M. New modality for the quantitative evaluation of tissue elasticity using a forward-viewing radial-array echoendoscope for colorectal neoplasms Int J Colorectal Dis 10.1007/s00384-020-03790-w
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  25. Kataoka K, Ishikawa T, Ohno E, Mizutani Y, Iida T, Ishikawa E, Furukawa K, Nakamura M, Honda T, Ishigami M, Kawashima H, Hirooka Y, Fujishiro M. Differentiation between pancreatic metastases from renal cell carcinoma and pancreatic neuroendocrine neoplasm using endoscopic ultrasound Pancreatology 10.1016/j.pan.2021.07.001
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  28. Ishikawa T, Kawashima H, Ohno E, Iida T, Suzuki H, Uetsuki K, Yashika J, Yamada K, Yoshikawa M, Gibo N, Aoki T, Kataoka K, Mori H, Yamamura T, Furukawa K, Nakamura M, Hirooka Y, Fujishiro M. Clinical characteristics and long-term prognosis of autoimmune pancreatitis with renal lesions Sci Rep 10.1038/s41598-020-79899-3
  29. Matsuzaki I, Ebara T, Tsunemi M, Hatta Y, Yamamoto K, Baba A, Hattori M, Nakamura M, Fujishiro M. Effects of endoscopy-related procedure time on musculoskeletal disorders in Japanese endoscopists: a cross-sectional study Endosc Int Open 10.1055/a-1352-3850
  30. Kataoka K, Ishikawa T, Ohno E, Iida T, Suzuki H, Uetsuki K, Furukawa K, Nakamura M, Honda T, Ishigami M, Kawashima H, Hirooka Y, Fujishiro M. Endoscopic ultrasound elastography for small solid pancreatic lesions with or without main pancreatic duct dilatation Pancreatology 10.1016/j.pan.2020.12.012
  31. Nishida T, Nikura R, Nagata N, Honda T, Sunagozaka H, Shiratori Y, Tsuji S, Sumiyoshi T, Fujita T, Kiyotoki S, Yada T, Yamamoto K, Shinozaki T, Nakamatsu D, Yamada A, Fujishiro M. Feasibility and safety of colonoscopy performed by nonexperts for acute lower gastrointestinal bleeding: post hoc analysis Endosc Int Open 10.1055/a-1464-0809
  32. Suzuki H, Ishikawa T, Ohno E, Iida T, Uetsuki K, Yashika J, Yamada K, Yoshikawa M, Furukawa K, Nakamura M, Honda T, Ishigami M, Kawashima H, Fujishiro M. An initial trial of quantitative evaluation of autoimmune pancreatitis using shear wave elastography and shear wave dispersion in transabdominal ultrasound Pancreatology 10.1016/j.pan.2021.02.014
  33. Nagami Y, Hatta W, Tsuji Y, Yoshio T, Kakushima N, Hoteya S, Tsuji S, Fukunaga S, Hikichi T, Kobayashi M, Morita Y, Sumiyoshi T, Iguchi M, Tomida H, Inoue T, Mikami T, Hasatani K, Nishikawa J, Matsumura T, Nebiki H, Nakamatsu D, Ohnita K, Suzuki H, Ueyama H, Hayashi Y, Yoshida H, Fujishiro M, Masamune A, Fujiwara Y; Fight-Japan study group. Antithrombotics increase bleeding after endoscopic submucosal dissection for gastric cancer: Nationwide propensity score analysis Dig Endosc 10.1111/den.14151
  34. Kuno T, Yamamura T, Nakamura M, Maeda K, Sawada T, Mizutani Y, Esaki M, Ishikawa T, Furukawa K, Ohno E, Kawashima H, Fujishiro M. A forward-viewing radial-array echoendoscope is useful for diagnosing the depth of colorectal neoplasia invasion Surg Endosc 10.1007/s00464-020-07936-3
  35. Tsuji Y, Ushiku T, Shinozaki T, Yamashita H, Seto Y, Fukayama M, Fujishiro M, Oda I, Katai H, Taniguchi H, Hasatani K, Kaizaki Y, Oga A, Nishikawa J, Akasaka R, Endo M, Sugai T, Matsumoto T, Koike K. Risk for lymph node metastasis in Epstein-Barr virus-associated gastric carcinoma with submucosal invasion Dig Endosc 10.1111/den.13823
  36. Yamamoto K, Honda T, Ito T, Ishizu Y, Kuzuya T, Nakamura M, Miyahara R, Kawashima H, Ishigami M, Fujishiro M. The relationship between oral-origin bacteria in the fecal microbiome and albumin-bilirubin grade in patients with hepatitis C J Gastroenterol Hepatol 10.1111/jgh.15206
  37. Yoshida K, Desbiolles A, Feldman SF, Ahn SH, Alidjinou EK, Atsukawa M, Bocket L, Brunetto MR, Buti M, Carey I, Caviglia GP, Chen EQ, Cornberg M, Enomoto M, Honda M, Zu Siederdissen CH, Ishigami M, Janssen HLA, Maasoumy B, Matsui T, Matsumoto A, Nishiguchi S, Riveiro-Barciela M, Takaki A, Tangkijvanich P, Toyoda H, van Campenhout MJH, Wang B, Wei L, Yang HI, Yano Y, Yatsuhashi H, Yuen MF, Tanaka E, Lemoine M, Tanaka Y, Shimakawa Y. Hepatitis B Core-Related Antigen to Indicate High Viral Load: Systematic Review and Meta-Analysis of 10,397 Individual Participants Clin Gastroenterol Hepatol 10.1016/j.cgh.2020.04.045
  38. Matsuda N, Imai N, Kuzuya T, Yamamoto K, Ito T, Ishizu Y, Honda T, Ishigami M, Fujishiro M. Progression After Molecular Targeted Agents: Hepatic Arterial Changes and Transarterial Chemoembolization in Hepatocellular Carcinoma In Vivo 10.21873/invivo.12367
  39. Toriyama K, Yamamura T, Nakamura M, Maeda K, Sawada T, Mizutani Y, Ishikawa E, Furukawa K, Ishikawa T, Ohno E, Kawashima H, Fujishiro M. An evaluation of resectability among endoscopic treatment methods for rectal neuroendocrine tumors <10 mm Arab J Gastroenterol 10.1016/j.ajg.2021.05.007
  40. Tanaka H, Kawashima H, Ohno E, Ishikawa T, Iida T, Ishikawa E, Furukawa K, Nakamura M, Honda T, Shimoyama Y, Miyahara R, Kawabe N, Kuzuya T, Hashimoto S, Ishigami M, Hirooka Y, Fujishiro M. Immunohistochemical staining for IMP3 in patients with duodenal papilla tumors: assessment of the potential for diagnosing endoscopic resectability and predicting prognosis BMC Gastroenterol 10.1186/s12876-021-01811-8
  41. Ito T, Ishigami M, Zou B, Tanaka T, Takahashi H, Kurosaki M, Maeda M, Thin KN, Tanaka K, Takahashi Y, Itoh Y, Oniki K, Seko Y, Saruwatari J, Kawanaka M, Atsukawa M, Hyogo H, Ono M, Ogawa E, Barnett SD, Stave CD, Cheung RC, Fujishiro M, Eguchi Y, Toyoda H, Nguyen MH. The epidemiology of NAFLD and lean NAFLD in Japan: a meta-analysis with individual and forecasting analysis, 1995-2040 Hepatol Int 10.1007/s12072-021-10143-4
  42. Nakamura M, Yano T, Esaki M, Oka S, Mitsui K, Hirai F, Kawasaki K, Fujishiro M, Torisu T, Tanaka S, Iwakiri K, Kishi M, Matsumoto T, Yamamoto H. Novel ultrathin double-balloon endoscopy for the diagnosis of small-bowel diseases: a multicenter nonrandomized study Endoscopy 10.1055/a-1243-0226
  43. Hasegawa I, Yamamura T, Suzuki H, Maeda K, Sawada T, Mizutani Y, Ishikawa E, Ishikawa T, Kakushima N, Furukawa K, Ohno E, Kawashima H, Nakamura M, Fujishiro M. Detection of Colorectal Neoplasms Using Linked Color Imaging: A Prospective, Randomized, Tandem Colonoscopy Trial Clin Gastroenterol Hepatol 10.1016/j.cgh.2021.04.004
  44. Yamamoto T, Imai N, Yamamoto K, Ito T, Ishizu Y, Honda T, Okamoto S, Kanematsu T, Suzuki N, Matsushita T, Ishigami M, Fujishiro M. Tolerability of Molecular-targeted Agents for Hepatocellular Carcinoma Treatment in Haemophiliacs Anticancer Res 10.21873/anticanres.15035
  45. Muroi K, Miyahara R, Funasaka K, Furukawa K, Sawada T, Maeda K, Yamamura T, Ishikawa T, Ohno E, Nakamura M, Kawashima H, Onoue T, Arima H, Hirooka Y, Fujishiro M. Comparison of High-Resolution Manometry in Patients Complaining of Dysphagia among Patients with or without Diabetes Mellitus Digestion 10.1159/000510081
  46. Yamada K, Ishikawa T, Ohno E, Iida T, Suzuki H, Uetsuki K, Yashika J, Yoshikawa M, Takami H, Inokawa Y, Uchida H, Kawashima H, Fujishiro M. Double common bile duct associated with pancreaticobiliary maljunction Nagoya J Med Sci 10.18999/nagjms.83.3.655
  47. Hashimoto M, Hatta W, Tsuji Y, Yoshio T, Yabuuchi Y, Hoteya S, Doyama H, Nagami Y, Hikichi T, Kobayashi M, Morita Y, Sumiyoshi T, Iguchi M, Tomida H, Inoue T, Mikami T, Hasatani K, Nishikawa J, Matsumura T, Nebiki H, Nakamatsu D, Ohnita K, Suzuki H, Ueyama H, Hayashi Y, Sugimoto M, Fujishiro M, Masamune A, Ohira H; Collaborators. Rebleeding in patients with delayed bleeding after endoscopic submucosal dissection for early gastric cancer Dig Endosc 10.1111/den.13943
  48. Yashika J, Ohno E, Ishikawa T, Iida T, Suzuki H, Uetsuki K, Yamada K, Yoshikawa M, Gibo N, Shimoyama Y, Ishikawa E, Furukawa K, Nakamura M, Honda T, Ishigami M, Hirooka Y, Kawashima H, Fujishiro M. Utility of multiphase contrast enhancement patterns on CEH-EUS for the differential diagnosis of IPMN-derived and conventional pancreatic cancer Pancreatology 10.1016/j.pan.2020.12.022
  49. Ohno E, Kawashima H, Ishikawa T, Iida T, Suzuki H, Uetsuki K, Yashika J, Yamada K, Yoshikawa M, Gibo N, Aoki T, Kataoka K, Mori H, Yamamura T, Furukawa K, Nakamura M, Hirooka Y, Fujishiro M. Diagnostic performance of endoscopic ultrasonography-guided elastography for solid pancreatic lesions: Shear-wave measurements versus strain elastography with histogram analysis Dig Endosc 10.1111/den.13791
  50. Esaki M, Yamamura T, Nakamura M, Maeda K, Sawada T, Mizutani Y, Ishikawa E, Suzuki H, Kuno T, Yamada K, Hasegawa I, Ishikawa T, Kakushima N, Furukawa K, Ohno E, Kawashima H, Hirooka Y, Fujishiro M. Endoscopic Ultrasound Elastography as a Novel Diagnostic Method for the Assessment of Hardness and Depth of Invasion in Colorectal Neoplasms Digestion 10.1159/000511589
  51. Ito N, Funasaka K, Furukawa K, Kakushima N, Hirose T, Muroi K, Suzuki T, Suzuki T, Hida E, Ishikawa T, Yamamura T, Ohno E, Nakamura M, Kawashima H, Miyahara R, Fujishiro M. A novel scoring system to predict therapeutic intervention for non-variceal upper gastrointestinal bleeding Intern Emerg Med 10.1007/s11739-021-02822-9
  52. Tsutsumi K, Kato M, Kakushima N, Iguchi M, Yamamoto Y, Kanetaka K, Uraoka T, Fujishiro M, Sho M; Japan Duodenal Cancer Guideline Committee. Efficacy of endoscopic preventive procedures to reduce delayed adverse events after endoscopic resection of superficial nonampullary duodenal epithelial tumors: a meta-analysis of observational comparative trials Gastrointest Endosc 10.1016/j.gie.2020.08.017
  53. Kawashima H, Ohno E, Ishikawa T, Iida T, Tanaka H, Furukawa K, Nakamura M, Honda T, Hashimoto S, Itoh A, Ishigami M, Hirooka Y, Fujishiro M. Endoscopic papillectomy for ampullary adenoma and early adenocarcinoma: Analysis of factors related to treatment outcome and long-term prognosis Dig Endosc 10.1111/den.13881
  54. Yoshioka N, Tanaka M, Ochi K, Watanabe A, Ono K, Sawada M, Ogi T, Itoh M, Ito A, Shiraki Y, Enomoto A, Ishigami M, Fujishiro M, Ogawa Y, Suganami T. The sodium-glucose cotransporter-2 inhibitor Tofogliflozin prevents the progression of nonalcoholic steatohepatitis-associated liver tumors in a novel murine model Biomed Pharmacother 10.1016/j.biopha.2021.111738
  55. Muto H, Ito T, Tanaka T, Yokoyama S, Yamamoto K, Imai N, Ishizu Y, Maeda K, Honda T, Ishikawa T, Kato A, Ohshiro T, Kano F, Yamamoto A, Sakai K, Hibi H, Ishigami M, Fujishiro M. Conditioned medium from stem cells derived from human exfoliated deciduous teeth ameliorates NASH via the Gut-Liver axis Sci Rep 10.1038/s41598-021-98254-8
  56. Aoki T, Yamada A, Kato Y, Saito H, Tsuboi A, Nakada A, Niikura R, Fujishiro M, Oka S, Ishihara S, Matsuda T, Nakahori M, Tanaka S, Koike K, Tada T. Automatic detection of various abnormalities in capsule endoscopy videos by a deep learning-based system: a multicenter study Gastrointest Endosc 10.1016/j.gie.2020.04.080
  57. Suzuki H, Ishikawa T, Ohno E, Kawashima H, Fujishiro M. Gastrointestinal: Pancreatic metastasis from extramammary Paget's disease diagnosed by endoscopic ultrasound-guided fine-needle biopsy J Gastroenterol Hepatol 10.1111/jgh.15444
  58. Kiyotoki S, Nishikawa J, Nagata N, Niikura R, Doyama H, Imagawa A, Hasatani K, Hatta W, Sumiyoshi T, Nebiki H, Nagami Y, Nishida T, Kakushima N, Iguchi M, Tomida H, Inoue T, Kuribayashi S, Narasaka T, Hikichi T, Yada T, Ochiai Y, Furuhashi H, Yoshio T, Mori H, Yamauchi K, Kitamura K, Fujita T, Mabe K, Mikami T, Goto A, Akashi M, Hamamoto Y, Fujishiro M, Sakaida I. Exploration of the characteristics of chronotypes in upper gastrointestinal tract diseases: a multicenter study in Japan Chronobiol Int 10.1080/07420528.2020.1830791
  59. Kobayashi K, Furukawa K, Ishikawa E, Mitsuma A, Funasaka K, Kakushima N, Furune S, Ito N, Wada H, Hirose T, Muroi K, Suzuki T, Suzuki T, Hida E, Hirai K, Shibata H, Koya T, Nakamura M, Kawashima H, Miyahara R, Fujishiro M. Collision Tumors of Gastric Adenocarcinoma and Mucosa-associated Lymphoid Tissue Lymphoma Intern Med 10.2169/internalmedicine.6124-20
  60. Ishizu Y, Ishigami M, Honda T, Kuzuya T, Ito T, Komada T, Fujishiro M. Simplification of balloon-occluded retrograde transcatheter obliteration procedure using a coaxial double balloon catheter compared with a single-balloon catheter Jpn J Radiol 10.1007/s11604-020-01060-x
  61. Muroi K, Kakushima N, Furukawa K, Ishikawa E, Sawada T, Ishikawa T, Maeda K, Yamamura T, Ohno E, Nakamura M, Kawashima H, Funasaka K, Miyahara R, Fujishiro M. Subjective Symptoms in Patients with Eosinophilic Esophagitis Are Related to Esophageal Wall Thickness and Esophageal Body Pressure Dig Dis Sci 10.1007/s10620-020-06527-5
  62. Yoshida M, Yabuuchi Y, Kakushima N, Kato M, Iguchi M, Yamamoto Y, Kanetaka K, Uraoka T, Fujishiro M, Sho M; Japan Duodenal Cancer Guideline Committee. The incidence of non-ampullary duodenal cancer in Japan: The first analysis of a national cancer registry J Gastroenterol Hepatol 10.1111/jgh.15285
  63. Ishikawa E, Nakaguro M, Nakamura M, Yamamura T, Sawada T, Mizutani Y, Maeda K, Furukawa K, Shimoyama Y, Kawashima H, Fujishiro M. Gastrointestinal tract metastasis of lung cancer: The PD-L1 expression and correlated clinicopathological variables Pathol Int 10.1111/pin.13048
  64. Furukawa K, Sato K, Okachi S, Kawashima H, Fujishiro M. Surgical mask designed for endoscopic procedures to prevent the diffusion of droplets Acta Gastroenterol Belg 10.51821/84.3.024
  65. Imai N, Yokoyama S, Yamamoto K, Ito T, Ishizu Y, Honda T, Ishigami M. Safety and Efficacy of Glass Membrane Pumping Emulsification Device in Transarterial Chemoembolization for Hepatocellular Carcinoma: First Clinical Outcomes Anticancer Res 10.21873/anticanres.15399
  66. Ozawa N, Sato K, Sugimura A, Maki S, Tanaka T, Yamamoto K, Ito T, Ishizu Y, Kuzuya T, Honda T, Ishigami M, Fujishiro M, Ishikawa T, Ando S. Quality of Life in patients with nonalcoholic fatty liver disease: Structure and related factors focusing on illness uncertainty Jpn J Nurs Sci 10.1111/jjns.12415
  67. Ishigami M, Honda T, Ishizu Y, Imai N, Ito T, Yamamoto K, Kamei H, Ogura Y, Fujishiro M. Revisiting Prognosis After Liver Transplant in Patients Positive for Hepatitis C Virus: Focus on Hepatitis C Recurrence-Unrelated Complications Exp Clin Transplant 10.6002/ect.2021.0197
  68. Muto H, Kuzuya T, Ito T, Ishizu Y, Honda T, Ishikawa T, Ishigami M, Fujishiro M. Transient deterioration of albumin-bilirubin scores in early post-dose period of molecular targeted therapies in advanced hepatocellular carcinoma with 50% or higher liver occupation: A STROBE-compliant retrospective observational study Medicine (Baltimore) 10.1097/MD.0000000000026820
  69. Zhao R, Nakamura M, Wu S, Uchida G, Yamamura T, Gao YJ, Goto H, Fujishiro M, Ge ZZ. The role of early video capsule endoscopy in the diagnosis and prognosis of obscure gastrointestinal bleeding: A multi-center propensity score matching study J Gastroenterol Hepatol 10.1111/jgh.15491
  70. Tomida H, Yoshio T, Igarashi K, Morita Y, Oda I, Inoue T, Hikichi T, Sumiyoshi T, Doyama H, Tsuji Y, Nishikawa J, Hatta W, Mikami T, Iguchi M, Sumiyama K, Yamamoto K, Kitamura K, Kuribayashi S, Yanagitani A, Uraoka T, Yada T, Hasatani K, Kawaguchi K, Fujita T, Nishida T, Hiasa Y, Fujishiro M; FIGHT-Japan Study Group. Influence of anticoagulants on the risk of delayed bleeding after gastric endoscopic submucosal dissection: a multicenter retrospective study Gastric Cancer 10.1007/s10120-020-01105-0
  71. Niikura R, Fujishiro M, Nakai Y, Matsuda K, Kawahara T, Yamada A, Tsuji Y, Hayakawa Y, Koike K. International Observational Survey of the Effectiveness of Personal Protective Equipment during Endoscopic Procedures Performed in Patients with COVID-19 Digestion 10.1159/000513714
  72. Amano H, Shirota C, Tainaka T, Sumida W, Yokota K, Makita S, Takimoto A, Tanaka Y, Hinoki A, Kawashima H, Uchida H. Late postoperative complications of congenital biliary dilatation in pediatric patients: a single-center experience of managing complications for over 20 years Surg Today 10.1007/s00595-021-02238-0
  73. Takada Y, Ishikawa T, Kawashima H. An Unusual Pancreatic Mass with Ductal Disruption: Benign or Malignant? Gastroenterology 10.1053/j.gastro.2021.06.059
  74. Murate K, Nakamura M, Yamamura T, Maeda K, Sawada T, Mizutani Y, Ishikawa E, Kakushima N, Furukawa K, Ohno E, Honda T, Kawashima H, Ishigami M, Fujishiro M. Ustekinumab is effective against small bowel lesions in Crohn's disease: two case reports Clin J Gastroenterol 10.1007/s12328-020-01242-0
  75. Yabuuchi Y, Hatta W, Tsuji Y, Yoshio T, Kakushima N, Hoteya S, Doyama H, Nagami Y, Hikichi T, Kobayashi M, Morita Y, Sumiyoshi T, Iguchi M, Tomida H, Inoue T, Mikami T, Hasatani K, Nishikawa J, Matsumura T, Nebiki H, Nakamatsu D, Ohnita K, Suzuki H, Ueyama H, Hayashi Y, Sugimoto M, Yamaguchi S, Michida T, Yada T, Asahina Y, Narasaka T, Kuribayashi S, Kiyotoki S, Mabe K, Fujishiro M, Masamune A, Ono H. Influence of hospital volume on bleeding after endoscopic submucosal dissection for early gastric cancer in Japan: a multicenter propensity score-matched analysis Surg Endosc 10.1007/s00464-021-08721-6
  76. Ishikawa T, Ohno E, Mizutani Y, Iida T, Koya T, Sasaki Y, Ogawa H, Kinoshita F, Hirooka Y, Kawashima H. Comparison of contrast-enhanced transabdominal ultrasonography following endoscopic ultrasonography with GD-EOB-DTPA-enhanced MRI for the sequential diagnosis of liver metastasis in patients with pancreatic cancer J Hepatobiliary Pancreat Sci 10.1002/jhbp.1097
  77. Shimada M, Hirashima N, Iwase H, Saito M, Kondo H, Urata N, Unita S, Kondo T, Tanaka D, Tsunekawa T, Fujishiro M. Evaluation of Muscle Cramp Associated with Liver Cirrhosis with a Focus on the Liver Function and Nutritional Status Intern Med 10.2169/internalmedicine.6231-20
  78. Shirota C, Kawashima H, Tainaka T, Sumida W, Yokota K, Makita S, Amano H, Takimoto A, Hinoki A, Uchida H. Double-balloon endoscopic retrograde cholangiography can make a reliable diagnosis and good prognosis for postoperative complications of congenital biliary dilatation Sci Rep 10.1038/s41598-021-90550-7
  79. Ishikawa T, Kawashima H, Ohno E, Nakamura M, Yamada S, Hayashi M, Fujishiro M. Endoscopic removal of a fish bone piercing the bile duct after pancreaticoduodenectomy Endoscopy 10.1055/a-1224-3724
  80. Sugimoto M, Hatta W, Tsuji Y, Yoshio T, Yabuuchi Y, Hoteya S, Doyama H, Nagami Y, Hikichi T, Kobayashi M, Morita Y, Sumiyoshi T, Iguchi M, Tomida H, Inoue T, Mikami T, Hasatani K, Nishikawa J, Matsumura T, Nebiki H, Nakamatsu D, Ohnita K, Suzuki H, Ueyama H, Hayashi Y, Murata M, Yamaguchi S, Michida T, Yada T, Asahina Y, Narasaka T, Kuribayashi S, Kiyotoki S, Mabe K, Fujishiro M, Masamune A, Kawai T. Risk Factors for Bleeding After Endoscopic Submucosal Dissection for Gastric Cancer in Elderly Patients Older Than 80 Years in Japan Clin Transl Gastroenterol 10.14309/ctg.0000000000000404
  81. Nishida T, Niikura R, Nagata N, Honda T, Sunagozaka H, Shiratori Y, Tsuji S, Sumiyoshi T, Fujita T, Kiyotoki S, Yada T, Yamamoto K, Shinozaki T, Nakamatsu D, Yamada A, Fujishiro M. Erratum: Feasibility and safety of colonoscopy performed by nonexperts for acute lower gastrointestinal bleeding: post hoc analysis Endosc Int Open 10.1055/a-1548-4517
  82. Yamamoto T, Hamajima E, Kamioka T, Nakae Y, Nakashima S, Kuno T, Ito M, Fujishiro M. [A case of mucosal prolapse syndrome complicated by well-differentiated tubular adenocarcinoma and high-grade adenoma after long-term follow-up by colonoscopy] Nihon Shokakibyo Gakkai Zasshi 10.11405/nisshoshi.118.757
  83. Shimada M, Hirashima N, Iwase H, Saito M, Kondo H, Urata N, Unita S, Kondo T, Tanaka D, Tsunekawa T, Nakamura S, Nishikura M, Miyazawa K, Fukuhara K, Fujishiro M. Evaluating patient acceptability and bowel preparation efficacy of sodium picosulfate-magnesium citrate for colonoscopy DEN open 10.1002/deo2.59
  84. Sakamoto Y, Yoshio S, Doi H, Mori T, Matsuda M, Kawai H, Shimagaki T, Yoshikawa S, Aoki Y, Osawa Y, Yoshida Y, Arai T, Itokawa N, Atsukawa M, Ito T, Honda T, Mise Y, Ono Y, Takahashi Y, Saiura A, Taketomi A, Kanto T. Increased Frequency of Dysfunctional Siglec-7(-)CD57(+)PD-1(+) Natural Killer Cells in Patients With Non-alcoholic Fatty Liver Disease Front Immunol 10.3389/fimmu.2021.603133
  85. Nakamura M, Watanabe K, Ohmiya N, Hirai F, Omori T, Tokuhara D, Nakaji K, Nouda S, Esaki M, Sameshima Y, Goto H, Terano A, Tajiri H, Matsui T; J-POP study group. Tag-less patency capsule for suspected small bowel stenosis: Nationwide multicenter prospective study in Japan Dig Endosc 10.1111/den.13673
  86. Kita T, Ashizuka S, Ohmiya N, Yamamoto T, Kanai T, Motoya S, Hirai F, Nakase H, Moriyama T, Nakamura M, Suzuki Y, Kanmura S, Kobayashi T, Ohi H, Nozaki R, Mitsuyama K, Yamamoto S, Inatsu H, Watanabe K, Hibi T, Kitamura K. Adrenomedullin for steroid-resistant ulcerative colitis: a randomized, double-blind, placebo-controlled phase-2a clinical trial J Gastroenterol 10.1007/s00535-020-01741-4
  87. Watanabe K, Ohmiya N, Nakamura M, Fujiwara Y. A Prospective Study Evaluating the Clinical Utility of the Tag-Less Patency Capsule with Extended Time for Confirming Functional Patency Digestion 10.1159/000503027
  88. Yamashita K, Yube Y, Yamazaki Y, Fukuchi T, Kato M, Koike T, Uehara T, Ikeda Y, Furune S, Murakami H, Kubota E, Fujioka S, Sato Y, Jin X, Suzuki T, Furukawa K, Tsuboi Y. The impact of tube replacement timing during LCIG therapy on PEG-J associated adverse events: a retrospective multicenter observational study BMC Neurol 10.1186/s12883-021-02269-7
  89. Ohno E. Paradigm shift in image-enhanced endoscopic ultrasonography Dig Endosc 10.1111/den.13906
  90. Ohno E, Hirooka Y. Encyclopedia of autoimmune pancreatitis: this is all we need J Med Ultrason (2001) 10.1007/s10396-021-01150-x
  91. Kitano M, Yamashita Y, Kamata K, Ang TL, Imazu H, Ohno E, Hirooka Y, Fusaroli P, Seo DW, Napoléon B, Teoh AYB, Kim TH, Dietrich CF, Wang HP, Kudo M; Working group for the International Consensus Guidelines for Contrast-Enhanced Harmonic Endoscopic Ultrasound. The Asian Federation of Societies for Ultrasound in Medicine and Biology (AFSUMB) Guidelines for Contrast-Enhanced Endoscopic Ultrasound Ultrasound Med Biol 10.1016/j.ultrasmedbio.2021.01.030
  92. Li Y, Imai N, Nicholls HT, Roberts BR, Goyal S, Krisko TI, Ang LH, Tillman MC, Roberts AM, Baqai M, Ortlund EA, Cohen DE, Hagen SJ. Thioesterase superfamily member 1 undergoes stimulus-coupled conformational reorganization to regulate metabolism in mice Nat Commun. 10.1038/s41467-021-23595-x
  93. Ritter MJ, Amano I, Imai N, Soares De Oliveira L, Vella KR, Hollenberg AN Nuclear Receptor CoRepressors, NCOR1 and SMRT, are required for maintaining systemic metabolic homeostasis Mol Metab doi: 10.1016/j.molmet.2021.101315

• 2020

  1. Niikura R, Nagata N, Yamada A, Honda T, Hasatani K, Ishii N, Shiratori Y, Doyama H, Nishida T, Sumiyoshi T, Fujita T, Kiyotoki S, Yada T, Yamamoto K, Shinozaki T, Takata M, Mikami T, Mabe K, Hara K, Fujishiro M, Koike K. Efficacy and Safety of Early vs Elective Colonoscopy for Acute Lower Gastrointestinal Bleeding Gastroenterology 10.1053/j.gastro.2019.09.010
  2. Yoshioka N, Ishigami M, Watanabe Y, Sumi H, Doisaki M, Yamaguchi T, Ito T, Ishizu Y, Kuzuya T, Honda T, Ishikawa T, Haruta JI, Fujishiro M. Effect of weight change and lifestyle modifications on the development or remission of nonalcoholic fatty liver disease: sex-specific analysis Sci Rep 10.1038/s41598-019-57369-9
  3. Taylor RS, Taylor RJ, Bayliss S, Hagström H, Nasr P, Schattenberg JM, Ishigami M, Toyoda H, Wai-Sun Wong V, Peleg N, Shlomai A, Sebastiani G, Seko Y, Bhala N, Younossi ZM, Anstee QM, McPherson S, Newsome PN. Association Between Fibrosis Stage and Outcomes of Patients With Nonalcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis Gastroenterology 10.1053/j.gastro.2020.01.043
  4. Ohno E, Hirooka Y, Kawashima H, Ishikawa T, Fujishiro M. Endoscopic ultrasonography for the evaluation of pancreatic cystic neoplasms J Med Ultrason (2001) 10.1007/s10396-019-00980-0
  5. Yamada K, Kawashima H, Ohno E, Ishikawa T, Tanaka H, Nakamura M, Miyahara R, Ishigami M, Hirooka Y, Fujishiro M. Diagnosis of vascular invasion in pancreatic ductal adenocarcinoma using endoscopic ultrasound elastography BMC Gastroenterol 10.1186/s12876-020-01228-9
  6. Furukawa K, Miyahara R, Funasaka K, Fujishiro M. Localized Gastric Amyloidosis J Gastrointestin Liver Dis 10.15403/jgld-3088
  7. Sasaki Y, Ishikawa T, Kawashima H, Ohno E, Shimoyama Y, Ishikawa E, Fujishiro M. Gender difference in the transabdominal ultrasound findings of solid-pseudopapillary neoplasm Pancreatology 10.1016/j.pan.2020.06.016
  8. Hosono I, Miyahara R, Furukawa K, Funasaka K, Sawada T, Maeda K, Yamamura T, Ishikawa T, Ohno E, Nakamura M, Kawashima H, Yokoi T, Tsukamoto T, Hirooka Y, Fujishiro M. Use of Immunostaining for the diagnosis of Lymphovascular invasion in superficial Barrett's esophageal adenocarcinoma BMC Gastroenterol 10.1186/s12876-020-01319-7
  9. Suzuki H, Kawashima H, Ohno E, Ishikawa T, Hashimoto S, Nakamura M, Miyahara R, Ishigami M, Hirooka Y, Fujishiro M. What is the role of measuring shear wave dispersion using shear wave elastography in pancreatic parenchyma? J Med Ultrason (2001) 10.1007/s10396-020-01033-7
  10. Nishio R, Kawashima H, Nakamura M, Ohno E, Ishikawa T, Yamamura T, Maeda K, Sawada T, Tanaka H, Sakai D, Miyahara R, Ishigami M, Hirooka Y, Fujishiro M. Double-balloon endoscopic retrograde cholangiopancreatography for patients who underwent liver operation: A retrospective study World J Gastroenterol 10.3748/wjg.v26.i10.1056
  11. Fujishiro M, Furukawa K, Yamamura T, Nakamura M, Honda T, Maeda O, Ishigami M, Kawashima H. Nonexposed wall-inversion surgery as a novel local resection method for neoplasms in the gastrointestinal tract Nagoya J Med Sci 10.18999/nagjms.82.2.175
  12. Zorron Cheng Tao Pu L, Chiam KH, Yamamura T, Nakamura M, Berzin TM, Mir FF, Hourneaux de Moura EG, Madruga Neto AC, Koay DSC, Loong CK, Ovenden A, Edwards S, Burt AD, Hirooka Y, Fujishiro M, Singh R. Narrow-band imaging for scar (NBI-SCAR) classification: from conception to multicenter validation Gastrointest Endosc 10.1016/j.gie.2019.08.036
  13. Furukawa K, Nakamura M, Fujishiro M. [Endoscopic screening for gastric cancer] Nihon Shokakibyo Gakkai Zasshi 10.11405/nisshoshi.117.469
  14. Murate K, Maeda K, Nakamura M, Sugiyama D, Wada H, Yamamura T, Sawada T, Mizutani Y, Ishikawa T, Furukawa K, Ohno E, Honda T, Kawashima H, Miyahara R, Ishigami M, Nishikawa H, Fujishiro M. Endoscopic Activity and Serum TNF-α Level at Baseline Are Associated With Clinical Response to Ustekinumab in Crohn's Disease Patients Inflamm Bowel Dis 10.1093/ibd/izaa086
  15. Niwa Y, Nakamura M, Kawashima H, Yamamura T, Maeda K, Sawada T, Mizutani Y, Ishikawa E, Ishikawa T, Kakushima N, Furukawa K, Ohno E, Honda T, Ishigami M, Fujishiro M. Accuracy of carbon dioxide insufflation for endoscopic retrograde cholangiopancreatography using double-balloon endoscopy World J Gastroenterol 10.3748/wjg.v26.i42.6669
  16. Kataoka Y, Tsuji Y, Hirasawa K, Takimoto K, Wada T, Mochizuki S, Ohata K, Sakaguchi Y, Niimi K, Ono S, Kodashima S, Yamamichi N, Fujishiro M, Koike K. Reply to Murakami et al Endoscopy 10.1055/a-1026-6136
  17. Yamamoto K, Kuzuya T, Honda T, Ito T, Ishizu Y, Nakamura M, Miyahara R, Kawashima H, Ishigami M, Fujishiro M. Relationship Between Adverse Events and Microbiomes in Advanced Hepatocellular Carcinoma Patients Treated With Sorafenib Anticancer Res 10.21873/anticanres.13996
  18. Saito H, Tanimoto T, Ozawa T, Ishihara S, Fujishiro M, Shichijo S, Hirasawa D, Matsuda T, Endo Y, Tada T. Automatic anatomical classification of colonoscopic images using deep convolutional neural networks Gastroenterol Rep (Oxf) 10.1093/gastro/goaa078
  19. Hattori S, Nakamura M, Yamamura T, Maeda K, Sawada T, Mizutani Y, Yamamoto K, Ishikawa T, Furukawa K, Ohno E, Honda T, Kawashima H, Ishigami M, Hirooka Y, Fujishiro M. The microbiome can predict mucosal healing in small intestine in patients with Crohn's disease J Gastroenterol 10.1007/s00535-020-01728-1
  20. Ishikawa T, Kawashima H, Ohno E, Iida T, Suzuki H, Uetsuki K, Yamada K, Yashika J, Yoshikawa M, Gibo N, Aoki T, Kataoka K, Mori H, Fujishiro M. Risks and characteristics of pancreatic cancer and pancreatic relapse in autoimmune pancreatitis patients J Gastroenterol Hepatol 10.1111/jgh.15163
  21. Ozawa T, Ishihara S, Fujishiro M, Kumagai Y, Shichijo S, Tada T. Automated endoscopic detection and classification of colorectal polyps using convolutional neural networks Therap Adv Gastroenterol 10.1177/1756284820910659
  22. Tanaka T, Kuzuya T, Ishigami M, Ito T, Ishizu Y, Honda T, Ishikawa T, Fujishiro M. Efficacy and Safety of Sorafenib in Unresectable Hepatocellular Carcinoma with Bile Duct Invasion Oncology 10.1159/000507051
  23. Zorron Cheng Tao Pu L, Maicas G, Tian Y, Yamamura T, Nakamura M, Suzuki H, Singh G, Rana K, Hirooka Y, Burt AD, Fujishiro M, Carneiro G, Singh R. Computer-aided diagnosis for characterization of colorectal lesions: comprehensive software that includes differentiation of serrated lesions Gastrointest Endosc 10.1016/j.gie.2020.02.042
  24. Zorron Cheng Tao Pu L, Yamamura T, Nakamura M, Koay DSC, Ovenden A, Edwards S, Burt AD, Hirooka Y, Fujishiro M, Singh R. Comparison of different virtual chromoendoscopy classification systems for the characterization of colorectal lesions JGH Open 10.1002/jgh3.12382
  25. Suzuki H, Nakamura M, Yamamura T, Maeda K, Sawada T, Mizutani Y, Ishikawa T, Furukawa K, Ohno E, Honda T, Kawashima H, Ishigami M, Fujishiro M. A Prospective Study of Factors Associated with Abdominal Pain in Patients during Unsedated Colonoscopy Using a Magnifying Endoscope Intern Med 10.2169/internalmedicine.4267-19
  26. Zorron Cheng Tao Pu L, Rana K, Singh G, Nakamura M, Yamamura T, Koay DSC, Ovenden A, Edwards S, Ruszkiewicz A, Hirooka Y, Fujishiro M, Burt AD, Singh R. Different factors are associated with conventional adenoma and serrated colorectal neoplasia Nagoya J Med Sci 10.18999/nagjms.82.2.335
  27. Sakamaki K, Funasaka K, Miyahara R, Furukawa K, Yamamura T, Ohno E, Nakamura M, Kawashima H, Hirooka Y, Fujishiro M, Goto H. Low ETV1 mRNA expression is associated with recurrence in gastrointestinal stromal tumors Sci Rep 10.1038/s41598-020-71719-y
  28. Ishimaru T, Kawashima H, Tainaka T, Suzuki K, Takami S, Kakihara T, Katoh R, Aoyama T, Uchida H, Iwanaka T. Laparoscopically Assisted Anorectoplasty for Intermediate-Type Imperforate Anus: Comparison of Surgical Outcomes with the Sacroperineal Approach J Laparoendosc Adv Surg Tech A 10.1089/lap.2018.0330
  29. Ohno E, Kawashima H, Ishikawa T, Iida T, Suzuki H, Uetsuki K, Yashika J, Yamada K, Yoshikawa M, Gibo N, Aoki T, Kataoka K, Mori H, Hirooka Y, Fujishiro M. Can contrast-enhanced harmonic endoscopic ultrasonography accurately diagnose main pancreatic duct involvement in intraductal papillary mucinous neoplasms? Pancreatology 10.1016/j.pan.2020.06.004
  30. Matsui K, Funasaka K, Miyahara R, Furukawa K, Matsushita M, Yamamura T, Ishikawa T, Ohno E, Nakamura M, Kawashima H, Watanabe O, Ohara K, Hirooka Y, Goto H. Generation of magnifying endoscopic images of gastric neoplasms based on an all-in-focus algorithm J Gastroenterol Hepatol 10.1111/jgh.14792
  31. Yamada K, Nakamura M, Yamamura T, Maeda K, Sawada T, Mizutani Y, Ishikawa T, Furukawa K, Ohno E, Miyahara R, Kawashima H, Hotta N, Hirooka Y. Clinical Factors Associated with Missing Colorectal Polyp on Colon Capsule Endoscopy Digestion 10.1159/000498942
  32. Ito T, Ishigami M, Morooka H, Yamamoto K, Imai N, Ishizu Y, Honda T, Nishimura D, Tada T, Yasuda S, Toyoda H, Kumada T, Fujishiro M. The albumin-bilirubin score as a predictor of outcomes in Japanese patients with PBC: an analysis using time-dependent ROC Sci Rep 10.1038/s41598-020-74732-3
  33. Emura F, Sharma P, Arantes V, Cerisoli C, Parra-Blanco A, Sumiyama K, Araya R, Sobrino S, Chiu P, Matsuda K, Gonzalez R, Fujishiro M, Tajiri H. Principles and practice to facilitate complete photodocumentation of the upper gastrointestinal tract: World Endoscopy Organization position statement Dig Endosc 10.1111/den.13530
  34. Zorron Cheng Tao Pu L, Yamamura T, Nakamura M, Esaki M, Kaosombatwattana U, Rodriguez MR, Edwards S, Burt AD, Singh R, Hirooka Y, Fujishiro M. Learning curve for mastery of colorectal endoscopic submucosal dissection: Perspectives from a large Japanese cohort JGH Open 10.1002/jgh3.12298
  35. Nomura A, Ishigami M, Honda T, Kuzuya T, Ishizu Y, Ito T, Kamei H, Onishi Y, Ogura Y, Fujishiro M. Limitation of non-transplant treatment and proper timing for liver transplantation in patients with hepatocellular carcinoma considering long-term survival Medicine (Baltimore) 10.1097/MD.0000000000021161
  36. Ishikawa E, Nakamura M, Shimada K, Tanaka T, Satou A, Kohno K, Sakakibara A, Furukawa K, Yamamura T, Miyahara R, Nakamura S, Kato S, Fujishiro M. Prognostic impact of PD-L1 expression in primary gastric and intestinal diffuse large B-cell lymphoma J Gastroenterol 10.1007/s00535-019-01616-3
  37. Ishikawa T, Kawashima H, Ohno E, Suhara H, Hayashi D, Hiramatsu T, Matsubara H, Suzuki T, Kuwahara T, Ishikawa E, Shimoyama Y, Kinoshita F, Hirooka Y, Fujishiro M. Usefulness of endoscopic ultrasound-guided fine-needle biopsy for the diagnosis of autoimmune pancreatitis using a 22-gauge Franseen needle: a prospective multicenter study Endoscopy 10.1055/a-1183-3583
  38. Hosokawa T, Hosokawa M, Tanami Y, Sato Y, Ishimaru T, Tanaka Y, Kawashima H, Oguma E. Use of ultrasound findings to predict bowel ischemic changes in pediatric patients with intestinal volvulus J Ultrasound Med 10.1002/jum.15145
  39. Ogiso S, Kamei H, Onishi Y, Kurata N, Jobara K, Kawashima H, Ogura Y. Decreased long-term graft survival in persistent biliary complications after right-lobe living-donor liver transplantation Clin Transplant 10.1111/ctr.13771
  40. Ishizu Y, Ishigami M, Hayashi K, Honda T, Kuzuya T, Ito T, Fujishiro M. Rapid increase of platelet counts during antiviral therapy in patients with hepatitis C virus infection Hepatol Res 10.1111/hepr.13426
  41. Zorron Cheng Tao Pu L, Yamamoto K, Honda T, Nakamura M, Yamamura T, Hattori S, Burt AD, Singh R, Hirooka Y, Fujishiro M. Microbiota profile is different for early and invasive colorectal cancer and is consistent throughout the colon J Gastroenterol Hepatol 10.1111/jgh.14868
  42. Kuzuya T, Ishigami M, Ito T, Ishizu Y, Honda T, Ishikawa T, Fujishiro M. Initial Experience of Ramucirumab Treatment After Lenvatinib Failure for Patients With Advanced Hepatocellular Carcinoma Anticancer Res 10.21873/anticanres.14167
  43. Zorron Cheng Tao Pu L, Singh G, Rana K, Nakamura M, Yamamura T, Krishnamurthi S, Ovenden A, Edwards S, Ruszkiewicz A, Hirooka Y, Fujishiro M, Burt AD, Singh R. Polyp Detection Rate as a Surrogate for Adenoma and Sessile Serrated Adenoma/Polyp Detection Rates Gastrointest Tumors 10.1159/000505622
  44. Mizuno K, Ito T, Ishigami M, Ishizu Y, Kuzuya T, Honda T, Kawashima H, Inukai Y, Toyoda H, Yokota K, Hase T, Maeda O, Kiyoi H, Nagino M, Hibi H, Kodera Y, Fujimoto Y, Sone M, Gotoh M, Ando Y, Akiyama M, Hasegawa Y, Fujishiro M. Real world data of liver injury induced by immune checkpoint inhibitors in Japanese patients with advanced malignancies J Gastroenterol 10.1007/s00535-020-01677-9
  45. Ishigami M, Honda T, Kuzuya T, Ishizu Y, Ito T, Kamei H, Ogura Y, Fujishiro M. Revisiting the indications for liver transplantation in cirrhotic patients considering the long-term outcomes of cirrhotic patients J Hepatobiliary Pancreat Sci 10.1002/jhbp.777
  46. Aoki T, Yamada A, Kato Y, Saito H, Tsuboi A, Nakada A, Niikura R, Fujishiro M, Oka S, Ishihara S, Matsuda T, Nakahori M, Tanaka S, Koike K, Tada T. Automatic detection of blood content in capsule endoscopy images based on a deep convolutional neural network J Gastroenterol Hepatol 10.1111/jgh.14941
  47. Kuzuya T, Ishigami M, Ito T, Ishizu Y, Honda T, Ishikawa T, Fujishiro M. Favorable radiological antitumor response at 2 weeks after starting lenvatinib for patients with advanced hepatocellular carcinoma Hepatol Res 10.1111/hepr.13452
  48. Goto O, Oyama T, Ono H, Takahashi A, Fujishiro M, Saito Y, Abe S, Kaise M, Iwakiri K, Yahagi N. Endoscopic hand-suturing is feasible, safe, and may reduce bleeding risk after gastric endoscopic submucosal dissection: a multicenter pilot study (with video) Gastrointest Endosc 10.1016/j.gie.2019.12.046
  49. Ito T, Ishigami M, Ishizu Y, Kuzuya T, Honda T, Ishikawa T, Toyoda H, Kumada T, Fujishiro M. Serum Nutritional Markers as Prognostic Factors for Hepatic and Extrahepatic Carcinogenesis in Japanese Patients with Nonalcoholic Fatty Liver Disease Nutr Cancer 10.1080/01635581.2019.1653474
  50. Kuzuya T, Ishigami M, Ito T, Ishizu Y, Honda T, Ishikawa T, Fujishiro M. Sorafenib vs. Lenvatinib as First-line Therapy for Advanced Hepatocellular Carcinoma With Portal Vein Tumor Thrombosis Anticancer Res 10.21873/anticanres.14193
  51. Aoki T, Yamada A, Aoyama K, Saito H, Fujisawa G, Odawara N, Kondo R, Tsuboi A, Ishibashi R, Nakada A, Niikura R, Fujishiro M, Oka S, Ishihara S, Matsuda T, Nakahori M, Tanaka S, Koike K, Tada T. Clinical usefulness of a deep learning-based system as the first screening on small-bowel capsule endoscopy reading Dig Endosc 10.1111/den.13517
  52. Saito H, Aoki T, Aoyama K, Kato Y, Tsuboi A, Yamada A, Fujishiro M, Oka S, Ishihara S, Matsuda T, Nakahori M, Tanaka S, Koike K, Tada T. Automatic detection and classification of protruding lesions in wireless capsule endoscopy images based on a deep convolutional neural network Gastrointest Endosc 10.1016/j.gie.2020.01.054
  53. Tsuboi A, Oka S, Aoyama K, Saito H, Aoki T, Yamada A, Matsuda T, Fujishiro M, Ishihara S, Nakahori M, Koike K, Tanaka S, Tada T. Artificial intelligence using a convolutional neural network for automatic detection of small-bowel angioectasia in capsule endoscopy images Dig Endosc 10.1111/den.13507
  54. Kawakubo M, Tanaka M, Ochi K, Watanabe A, Saka-Tanaka M, Kanamori Y, Yoshioka N, Yamashita S, Goto M, Itoh M, Shirakawa I, Kanai S, Suzuki H, Sawada M, Ito A, Ishigami M, Fujishiro M, Arima H, Ogawa Y, Suganami T. Dipeptidyl peptidase-4 inhibition prevents nonalcoholic steatohepatitis-associated liver fibrosis and tumor development in mice independently of its anti-diabetic effects Sci Rep 10.1038/s41598-020-57935-6
  55. Suzuki H, Yamamura T, Fujishiro M. Endoscopic detorsion using single-balloon endoscopy for cecal volvulus Dig Endosc 10.1111/den.13558
  56. Ito T, Ishigami M, Ishizu Y, Kuzuya T, Honda T, Ishikawa T, Toyoda H, Kumada T, Fujishiro M. Correlation of serum zinc levels with pathological and laboratory findings in patients with nonalcoholic fatty liver disease Eur J Gastroenterol Hepatol 10.1097/MEG.0000000000001587
  57. Hosokawa T, Takahashi H, Tanami Y, Sato Y, Ishimaru T, Tanaka Y, Kawashima H, Oguma E, Yamada Y. Diagnostic Accuracy of Ultrasound for the Directionality of Testicular Rotation and the Degree of Spermatic Cord Twist in Pediatric Patients With Testicular Torsion J Ultrasound Med 10.1002/jum.15084
  58. Nakamura M, Yamamura T, Maeda K, Sawada T, Mizutani Y, Ishikawa E, Ohashi A, Kajikawa G, Furukawa K, Ohno E, Honda T, Kawashima H, Ishigami M, Fujishiro M. Refractory Ulcerative Colitis Improved by Scheduled Combination Therapy of Vedolizumab and Granulocyte and Monocyte Adsorptive Apheresis Intern Med 10.2169/internalmedicine.5302-20
  59. Weber S, Benesic A, Ishigami M, Gerbes AL. Drug-Induced Liver Injury by Checkpoint Inhibitors: Benefit of a Causality Assessment Tool Hepatol Commun 10.1002/hep4.1565
  60. Funasaka K, Miyahara R, Furukawa K, Sawada T, Maeda K, Yamamura T, Ishikawa T, Ohno E, Nakamura M, Kawashima H, Hirooka Y, Ohmiya N, Fujishiro M. Mutation analysis of gastrointestinal stromal tumors using RNA obtained via endoscopic ultrasound-guided fine-needle aspiration Transl Oncol 10.1016/j.tranon.2020.100848
  61. Nishida T, Niikura R, Nakamatsu D, Fujishiro M. Is lower GI bleeding on weekend admissions associated with worse outcomes? Gastrointest Endosc 10.1016/j.gie.2020.05.058
  62. Hashiguchi H, Tsukamoto Y, Ogawa M, Tashima Y, Takeuchi H, Nakamura M, Kawashima H, Fujishiro M, Okajima T. Glycoproteomic analysis identifies cryptdin-related sequence 1 as O-glycosylated protein modified with α1,2-fucose in the small intestine Arch Biochem Biophys 10.1016/j.abb.2020.108653
  63. Kobayashi K, Miyahara R, Funasaka K, Furukawa K, Sawada T, Maeda K, Yamamura T, Ishikawa T, Ohno E, Nakamura M, Kawashima H, Nakaguro M, Okumura Y, Hirooka Y, Fujishiro M. Color information from linked color imaging is associated with invasion depth and vascular diameter in superficial esophageal squamous cell carcinoma Dig Endosc 10.1111/den.13469
  64. Miyagi S, Ishikawa E, Nakamura M, Shimada K, Yamamura T, Furukawa K, Tanaka T, Mabuchi S, Tsuyuki Y, Kohno K, Sakakibara A, Satou A, Kato S, Fujishiro M, Nakamura S. Reappraisal of Primary Epstein-Barr Virus (EBV)-positive Diffuse Large B-Cell Lymphoma of the Gastrointestinal Tract: Comparative Analysis Among Immunosuppressed and Nonimmunosuppressed Stage I and II-IV Patients Am J Surg Pathol 10.1097/PAS.0000000000001499
  65. Tsunemi M, Matsuzaki I, Hattori M, Ebara T, Fujishiro M. Sit-stand endoscopic workstations with wobble stools for the endoscopist, assistant, and endoscopy nurses in an endoscopy unit Endoscopy 10.1055/a-1122-8020
  66. Okada N, Iwama S, Okuji T, Kobayashi T, Yasuda Y, Wada E, Onoue T, Goto M, Sugiyama M, Tsunekawa T, Takagi H, Hagiwara D, Ito Y, Suga H, Banno R, Hase T, Morise M, Kanda M, Yokota K, Hashimoto N, Ando M, Fujimoto Y, Nagino M, Kodera Y, Fujishiro M, Hibi H, Sone M, Kiyoi H, Gotoh M, Ando Y, Akiyama M, Hasegawa Y, Arima H. Anti-thyroid antibodies and thyroid echo pattern at baseline as risk factors for thyroid dysfunction induced by anti-programmed cell death-1 antibodies: a prospective study Br J Cancer 10.1038/s41416-020-0736-7
  67. Yokota K, Amano H, Kudo T, Yamamura T, Tanaka Y, Tainaka T, Shirota C, Sumida W, Makita S, Takimoto A, Nakamura M, Fujishiro M, Hinoki A, Uchida H. A novel Lugol's iodine staining technique to visualize the upper margin of the surgical anal canal intraoperatively for Hirschsprung disease: a case series BMC Surg 10.1186/s12893-020-00986-3
  68. Muto H, Kuzuya T, Ito T, Ishizu Y, Honda T, Ishikawa T, Ishigami M, Fujishiro M. Complete response of advanced hepatocellular carcinoma achieved by sorafenib dose re-escalation after failure of long-term low-dose-sorafenib treatment combined with transcatheter arterial chemoembolization: a case report Clin J Gastroenterol 10.1007/s12328-019-01066-7
  69. Tillman MC, Imai N, Li Y, Khadka M, Okafor CD, Juneja P, Adhiyaman A, Hagen SJ, Cohen DE, Ortlund EA. Allosteric regulation of thioesterase superfamily member 1 by lipid sensor domain binding fatty acids and lysophosphatidylcholine Proc Natl Acad Sci U S A. 10.1073/pnas.2003877117.

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