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Message from the Dean

Greeting from the Dean of the School of Medicine/Graduate School of Medicine

門松研究科長As exemplified by the Excellence Initiative in Germany, nations in Europe and Asia are accelerating their efforts to each establish Research Excellence Initiatives of their own. These declare to go beyond the 4 boundaries posed by "scholarship, nation, language and culture, and systems," and state that the goal is to enhance the quality of scholarship, globalization, and to propel advances in organizations. Japan adopted the title of Designated National University in 2017. Tohoku University, the University of Tokyo, Tokyo Institute of Technology, Nagoya University, and Kyoto University are the 5 institutions that have received this designation.

We at Nagoya University Graduate School of Medicine are the first to offer a joint degree program (JDP) in Japan. This is a program where two leading institutions offer a collaborative graduate-level education and a single degree from both universities. Not only does this ensure the quality of the degree awarded but is significant in that it also allows actualization of global collaborations in education and research. We have already concluded agreements with the University of Adelaide (Australia) and Lund University (Sweden) and plan a similar agreement with University of Freiburg (Germany) during fiscal year 2018. A new program called Global Alliance of Medical Excellence (GAME) was also inaugurated in 2017. This is an initiative for cooperation among medical schools and graduate schools in medicine from around the world, comprising 9 universities: Nagoya University, the Chinese University of Hong Kong (Hong Kong), Korea University (South Korea), Monash University (Australia), Ludwig-Maximilians-University Munchen (German), Erasmus University Rotterdam (Holland), the University of Bologna (Italy), the University of Nottingham (UK), and University of Alberta (Canada). It will facilitate the global development of collaborative research and educational opportunities.

As birth rates decrease and life expectancy approaches three figures, both the field of medicine and the profession of healthcare are faced with unprecedented expectations from society. As a designated national university, Nagoya University proposed the establishment of 4 world-leading research centers around the world. One of those would be a focal center in medical and life sciences. With the aforementioned JDP and GAME as its pillars, we intend to expand the platform for international joint research and hope to create new pathways in medicine and healthcare. Trailblazing Medicine and Healthcare, this is our mission. Our goal is to confront the major issues we face as we undertake new challenges in basic medical research, enhance collaboration between basic and clinical medicine, and support the globalization of clinical medicine and healthcare.

July 2018
Dean of the School of Medicine and Graduate School of Medicine
Kenji Kadomatsu



Graduate School of Medicine Program in Integrated Medicine


Molecular Biology

Main Thesis
  1. Tsubota S, Kishida S, Shimamura T, Ohira M, Yamashita S, Cao D, Kiyonari S, Ushijima T, Kadomatsu K. PRC2-Mediated Transcriptomic Alterations at the Embryonic Stage Govern Tumorigenesis and Clinical Outcome in MYCN-Driven Neuroblastoma. Cancer Res. 77(19):5259-5271 (2017).
  2. Mu P, Akashi T, Lu F, Kishida S, Kadomatsu K. A novel nuclear complex of DRR1, F-actin and COMMD1 involved in NF-κB degradation and cell growth suppression in neuroblastoma. Oncogene. 36(41):5745-5756 (2017).
  3. Zhang Z, Takeda-Uchimura Y, Foyez T, Ohtake-Niimi S, Narentuya, Akatsu H, Nishitsuji K, Michikawa M, Wyss-Coray T, Kadomatsu K, Uchimura K. Deficiency of a sulfotransferase for sialic acid-modified glycans mitigates Alzheimer's pathology. Proc Natl Acad Sci U S A. 114(14):E2947-E2954 (2017)
  4. Sato Y, Sato W, Maruyama S, Wilcox CS, Falck JR, Masuda T, Kosugi T, Kojima H, Maeda K, Furuhashi K, Ando M, Imai E, Matsuo S, Kadomatsu K. Midkine Regulates BP through Cytochrome P450-Derived Eicosanoids. J Am Soc Nephrol. 26(8):1806-15 (2015).
  5. Kishida S, Mu P, Miyakawa S, Fujiwara M, Abe T, Sakamoto K, Onishi A, Nakamura Y, Kadomatsu K. Midkine Promotes Neuroblastoma through Notch2 Signaling. Cancer Res. 73(4):1318-27 (2013).
  6. Huang, P., Kishida, S., Cao, D., Murakami-Tonami, Y., Mu, P., Nakaguro, M., Koide, N., Takeuchi, I., Akina Onishi, A., Kadomatsu, K. The neuronal differentiation factor NeuroD1 downregulates the neuronal repellent factor Slit2 expression and promotes cell motility and tumor formation of neuroblastoma. Cancer Res. 71(8):2938-2948 (2011)
  7. Imagama S, Sakamoto K, Tauchi R, Shinjo R, Ohgomori T, Ito Z, Zhang H, Nishida Y, Asami N, Takeshita S, Sugiura N, Watanabe H, Yamashita T, Ishiguro N, Matsuyama Y, Kadomatsu K. Keratan sulfate restricts neural plasticity after spinal cord injury. J Neurosci. 31(47):17091-102 (2011)
  8. Ito Z, Sakamoto K, Imagama S, Matsuyama Y, Zhang H, Hirano K, Ando K, Yamashita T, Ishiguro N, Kadomatsu K. N-acetylglucosamine 6-O-sulfotransferase-1-deficient Mice Show Better Functional Recovery after Spinal Cord Injury. J. Neurosci. 30(17):5937-47 (2010).
  9. Kato N, Yuzawa Y, Kosugi T, Hobo A, Sato W, Miwa Y, Sakamoto K, Matsuo S, Kadomatsu K. The E-selectin ligand basigin/CD147 is responsible for neutrophil recruitment in renal ischemia/reperfusion. J Am Soc Nephrol. 20(7):1565-76 (2009).
  10. Hobo A, Yuzawa Y, Kosugi T, Kato N, Asai N, Sato W, Maruyama S, Ito Y, Kobori H, Ikematsu S, Nishiyama A, Matsuo S, Kadomatsu, K. The growth factor midkine regulates the renin-angiotensin system in mice. J. Clin. Invest. 119(6):1616-1625 (2009).