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Message from the Dean

Pioneering Medicine and Health Care

門松研究科長If I had to name only two national and global challenges for Japanese university medical schools in 2021, I would say that they are COVID-19 and research capabilities. With regard to COVID-19, we are facing an important issue of how to deal with social activities in the face of repeated waves of infection and breakthrough infections. Nagoya University Hospital, as one of the university hospitals that has treated the largest number of critically ill patients, is right in the middle of COVID-19 medical care. What kind of turning point will Japan face in the future, where the number of infected people is overwhelmingly small compared to the rest of the world? I believe that we have an extremely important responsibility from various perspectives, including development of vaccines and therapeutic agents, epidemiology of infection, and proposals to medical administration.

Research capability is also related to COVID-19, but it is a much deeper, long-term issue. Basic research, clinical research, and translational research are all part of the broad scope of medical research, and we are now in an age where multilayered research is required, with threads from informatics, chemistry, physics, engineering, and other fields woven into the mix. The core of the significance of our existence as academics is to pioneer medicine and medical treatment through this kind of research. However, it must be said that the position of medical research in Japan is in a precarious situation internationally. The Nagoya University Graduate School of Medicine is working to overcome this critical situation by promoting programs such as CIBoG, AI-MAILs, and GAME, which promote graduate education, interdisciplinary research, and international research. In addition, the fostering of young researchers is beginning to bear fruit, as five people have been hired for the JST "Fusion Oriented Research for Disruptive Science and Technology" in this, the first year of the program.

The Nagoya University School of Medicine, Graduate School of Medicine, and Medical School Hospital, celebrating its 150th anniversary since its establishment as a temporary hospital and medical school for the Nagoya domain in 1871, will continue to take steps toward the development of medicine and medical care that will contribute to the health of the people and humanity.

August 2021
Kenji Kadomatsu
Dean, Nagoya University Graduate School of Medicine



Graduate School of Medicine Program in Integrated Medicine


Molecular Biology

Main Thesis
  1. Sakamoto K, Ozaki T, Yen-Chun Ko, Cheng-Fang Tsai, Gong Y, Morozumi M, Ishikawa, Y, Uchimura K, Nadanaka S, Kitagawa H, Medel Manuel L. Zulueta, Anandaraju Bandaru, Tamura J, Shang-Cheng Hung, Kadomatsu K. Glycan sulfation patterns define autophagy flux at axon tip via PTPRσ-cortactin axis. Nat Chem Biol. 15(7):699-709 (2019).
  2. Tsubota S, Kishida S, Shimamura T, Ohira M, Yamashita S, Cao D, Kiyonari S, Ushijima T, Kadomatsu K. PRC2-Mediated Transcriptomic Alterations at the Embryonic Stage Govern Tumorigenesis and Clinical Outcome in MYCN-Driven Neuroblastoma. Cancer Res. 77(19):5259-5271 (2017).
  3. Mu P, Akashi T, Lu F, Kishida S, Kadomatsu K. A novel nuclear complex of DRR1, F-actin and COMMD1 involved in NF-κB degradation and cell growth suppression in neuroblastoma. Oncogene. 36(41):5745-5756 (2017).
  4. Zhang Z, Takeda-Uchimura Y, Foyez T, Ohtake-Niimi S, Narentuya, Akatsu H, Nishitsuji K, Michikawa M, Wyss-Coray T, Kadomatsu K, Uchimura K. Deficiency of a sulfotransferase for sialic acid-modified glycans mitigates Alzheimer's pathology. Proc Natl Acad Sci U S A. 114(14):E2947-E2954 (2017)
  5. Sato Y, Sato W, Maruyama S, Wilcox CS, Falck JR, Masuda T, Kosugi T, Kojima H, Maeda K, Furuhashi K, Ando M, Imai E, Matsuo S, Kadomatsu K. Midkine Regulates BP through Cytochrome P450-Derived Eicosanoids. J Am Soc Nephrol. 26(8):1806-15 (2015).
  6. Kishida S, Mu P, Miyakawa S, Fujiwara M, Abe T, Sakamoto K, Onishi A, Nakamura Y, Kadomatsu K. Midkine Promotes Neuroblastoma through Notch2 Signaling. Cancer Res. 73(4):1318-27 (2013).
  7. Huang, P., Kishida, S., Cao, D., Murakami-Tonami, Y., Mu, P., Nakaguro, M., Koide, N., Takeuchi, I., Akina Onishi, A., Kadomatsu, K. The neuronal differentiation factor NeuroD1 downregulates the neuronal repellent factor Slit2 expression and promotes cell motility and tumor formation of neuroblastoma. Cancer Res. 71(8):2938-2948 (2011)
  8. Imagama S, Sakamoto K, Tauchi R, Shinjo R, Ohgomori T, Ito Z, Zhang H, Nishida Y, Asami N, Takeshita S, Sugiura N, Watanabe H, Yamashita T, Ishiguro N, Matsuyama Y, Kadomatsu K. Keratan sulfate restricts neural plasticity after spinal cord injury. J Neurosci. 31(47):17091-102 (2011)
  9. Ito Z, Sakamoto K, Imagama S, Matsuyama Y, Zhang H, Hirano K, Ando K, Yamashita T, Ishiguro N, Kadomatsu K. N-acetylglucosamine 6-O-sulfotransferase-1-deficient Mice Show Better Functional Recovery after Spinal Cord Injury. J. Neurosci. 30(17):5937-47 (2010).
  10. Kato N, Yuzawa Y, Kosugi T, Hobo A, Sato W, Miwa Y, Sakamoto K, Matsuo S, Kadomatsu K. The E-selectin ligand basigin/CD147 is responsible for neutrophil recruitment in renal ischemia/reperfusion. J Am Soc Nephrol. 20(7):1565-76 (2009).
  11. Hobo A, Yuzawa Y, Kosugi T, Kato N, Asai N, Sato W, Maruyama S, Ito Y, Kobori H, Ikematsu S, Nishiyama A, Matsuo S, Kadomatsu, K. The growth factor midkine regulates the renin-angiotensin system in mice. J. Clin. Invest. 119(6):1616-1625 (2009).