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Message from the Dean

Greeting from the Dean of the School of Medicine/Graduate School of Medicine

門松研究科長Japan searched for an alternative title to embody the prestige and dignity represented by the former Seven Imperial Universities and adopted the title of Designated National University to indicate their status as globally competitive research institutions in 2017. Thus far, 6 universities including Tohoku University, the University of Tokyo, Tokyo Institute of Technology, Nagoya University, Kyoto University. and Osaka University have been endowed with this designation. Nagoya University Graduate School of Medicine has undertaken a mission to institute initiatives to trailblaze frontiers in medicine and healthcare. We at Nagoya University Graduate School of Medicine are the first to offer a joint degree program (JDP) in Japan. This is a program where two leading institutions offer a collaborative graduate-level education and a single degree from both universities. Not only does this ensure the quality of the degree awarded but is significant in that it also actualizes global collaborations in education and research. Our institution has concluded agreements with the University of Adelaide (Australia), Lund University (Sweden) and University of Freiburg (Germany) and a cooperative graduate education program has been initiated. This education and research consortium is named FLAN after the initials of these 4 Universities.
As of 2017, a new program called Global Alliance of Medical Excellence (GAME) was also inaugurated. This is an initiative for cooperation among medical schools and graduate schools in medicine from around the world, comprising 9 universities: Nagoya University, the Chinese University of Hong Kong (Hong Kong), Korea University (South Korea), Monash University (Australia), Ludwig-Maximilians-University Munich (Germany), Erasmus University Rotterdam (Holland), the University of Bologna (Italy), the University of Nottingham (UK), and University of Alberta (Canada). It will facilitate the global development of collaborative research and education opportunities. 
Together with these efforts aimed towards global cooperation and collaboration, we are bolstering our IT resources. The Division of Systems Biology was formally established in 2019 at the Tsuruma campus as an official department awaiting a professor to fill the position.
At the Daiko campus, a large-scale organizational reform has begun that incorporates information science. We are currently proceeding with creating a new organization that leads new advances in medicine and healthcare and utilizes artificial intelligence and ICT. Student research meetings, premium lectures, 3-department symposia, National Institute for Physiological Sciences symposia and retreats are also held to expand opportunities for young researchers to network. In the future, we will incorporate initiatives to enhance our capacity for clinical research/translational, research support, and industry-academia collaboration. 

August 2019
Dean of the School of Medicine and Graduate School of Medicine
Kenji Kadomatsu



Graduate School of Medicine Program in Integrated Medicine


Molecular Biology

Main Thesis
  1. Sakamoto K, Ozaki T, Yen-Chun Ko, Cheng-Fang Tsai, Gong Y, Morozumi M, Ishikawa, Y, Uchimura K, Nadanaka S, Kitagawa H, Medel Manuel L. Zulueta, Anandaraju Bandaru, Tamura J, Shang-Cheng Hung, Kadomatsu K. Glycan sulfation patterns define autophagy flux at axon tip via PTPRσ-cortactin axis. Nat Chem Biol. 15(7):699-709 (2019).
  2. Tsubota S, Kishida S, Shimamura T, Ohira M, Yamashita S, Cao D, Kiyonari S, Ushijima T, Kadomatsu K. PRC2-Mediated Transcriptomic Alterations at the Embryonic Stage Govern Tumorigenesis and Clinical Outcome in MYCN-Driven Neuroblastoma. Cancer Res. 77(19):5259-5271 (2017).
  3. Mu P, Akashi T, Lu F, Kishida S, Kadomatsu K. A novel nuclear complex of DRR1, F-actin and COMMD1 involved in NF-κB degradation and cell growth suppression in neuroblastoma. Oncogene. 36(41):5745-5756 (2017).
  4. Zhang Z, Takeda-Uchimura Y, Foyez T, Ohtake-Niimi S, Narentuya, Akatsu H, Nishitsuji K, Michikawa M, Wyss-Coray T, Kadomatsu K, Uchimura K. Deficiency of a sulfotransferase for sialic acid-modified glycans mitigates Alzheimer's pathology. Proc Natl Acad Sci U S A. 114(14):E2947-E2954 (2017)
  5. Sato Y, Sato W, Maruyama S, Wilcox CS, Falck JR, Masuda T, Kosugi T, Kojima H, Maeda K, Furuhashi K, Ando M, Imai E, Matsuo S, Kadomatsu K. Midkine Regulates BP through Cytochrome P450-Derived Eicosanoids. J Am Soc Nephrol. 26(8):1806-15 (2015).
  6. Kishida S, Mu P, Miyakawa S, Fujiwara M, Abe T, Sakamoto K, Onishi A, Nakamura Y, Kadomatsu K. Midkine Promotes Neuroblastoma through Notch2 Signaling. Cancer Res. 73(4):1318-27 (2013).
  7. Huang, P., Kishida, S., Cao, D., Murakami-Tonami, Y., Mu, P., Nakaguro, M., Koide, N., Takeuchi, I., Akina Onishi, A., Kadomatsu, K. The neuronal differentiation factor NeuroD1 downregulates the neuronal repellent factor Slit2 expression and promotes cell motility and tumor formation of neuroblastoma. Cancer Res. 71(8):2938-2948 (2011)
  8. Imagama S, Sakamoto K, Tauchi R, Shinjo R, Ohgomori T, Ito Z, Zhang H, Nishida Y, Asami N, Takeshita S, Sugiura N, Watanabe H, Yamashita T, Ishiguro N, Matsuyama Y, Kadomatsu K. Keratan sulfate restricts neural plasticity after spinal cord injury. J Neurosci. 31(47):17091-102 (2011)
  9. Ito Z, Sakamoto K, Imagama S, Matsuyama Y, Zhang H, Hirano K, Ando K, Yamashita T, Ishiguro N, Kadomatsu K. N-acetylglucosamine 6-O-sulfotransferase-1-deficient Mice Show Better Functional Recovery after Spinal Cord Injury. J. Neurosci. 30(17):5937-47 (2010).
  10. Kato N, Yuzawa Y, Kosugi T, Hobo A, Sato W, Miwa Y, Sakamoto K, Matsuo S, Kadomatsu K. The E-selectin ligand basigin/CD147 is responsible for neutrophil recruitment in renal ischemia/reperfusion. J Am Soc Nephrol. 20(7):1565-76 (2009).
  11. Hobo A, Yuzawa Y, Kosugi T, Kato N, Asai N, Sato W, Maruyama S, Ito Y, Kobori H, Ikematsu S, Nishiyama A, Matsuo S, Kadomatsu, K. The growth factor midkine regulates the renin-angiotensin system in mice. J. Clin. Invest. 119(6):1616-1625 (2009).