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Internal MedicineEndocrinology and Diabetes

Introduction

 The Department of Endocrinology and Diabetes was established in 2003. Under the leadership of Professor Arima, we provide fine care for patients with metabolic diseases and hormonal disorders such as pituitary dysfunction and thyroid diseases. We have also been performing basic and clinical research on endocrinology and metabolic diseases.

Research Projects

1. Elucidating Pathogenesis of Familial Neurohypophysial Diabetes Insipidus
 Familial neurohypophysial diabetes insipidus (FNDI) is an autosomal dominant inherited disease caused by mutations in arginine vasopressin (AVP) gene locus, mostly in neurophysin II-encoding region. Patients with FNDI manifest progressive polyuria several months or years after birth. In the AVP neurons of FNDI model mice, mutant proteins are confined to a certain compartment of endoplasmic reticulum (ERAC: Endoplasmic reticulum-associated compartment). In contrast, the failure of ERAC formation results in increase of ER stress in chronically dehydrated or aged FNDI mice, leading to cell death of AVP neurons. The meaning of ERAC formation is to maintain morphology and function of ER and relieve ER stress by segregating aberrant proteins accumulated in the ER. We are studying the mechanism of ERAC formation.

2. Analysis of the Mechanism of Arginine Vasopressin (AVP) Secretion
 AVP is secreted via exocytosis. The precise mechanism underlying the exocytosis of AVP remains to be elucidated. We have developed a mouse embryonic stem cell-derived AVP neuron culture system to investigate the molecular mechanism of AVP secretion by knockdown or overexpression experiments. Using this system, we recently reported that tomosyn negatively regulates AVP secretion.

3. Analysis of the Pathogenesis of Osmotic Demyelination Syndrome (ODS) and Hyponatremia
 ODS is a serious demyelination disease commonly associated with a rapid correction of chronic hyponatremia. We reported dexamethasone prevents ODS by inhibiting the disruption of the blood-brain barrier that is caused by the rapid correction of hyponatremia and that minocycline prevents ODS by inhibiting the activation of microglia in a rat model of syndrome of inappropriate antidiuretic hormone secretion (SIADH). We recently reported that chronic hyponatremia causes neurologic and psychologic impairments. The reduction of serum [Na+] in chronic hyponatremia induces gait disturbances, memory impairment and decreased long-term potentiation (LTP) at hippocampal CA3-CA1 synapses as an underlying mechanism of memory impairment.

4. Research on Lymphocytic Hypophysitis, Including Lymphocytic Infundibulo-neurohypophysitis (LINH)
 We found that rabphilin-3A is a major autoantigen in LINH and that autoantibodies to rabphilin-3A may serve as a biomarker for the diagnosis of LINH. We have also reported that Rab GDI alpha is a candidate autoantigen involved in isolated adrenocorticotropin deficiency (IAD). To evaluate the involvement of rabphilin-3A in the pathogenesis of LINH, we are studying on the animal model of LINH.

5. Regenerative Medicine for Hypothalamus and Adenohypophysis
 The aims of this research topic are to prepare hypothalamic and pituitary tissues from human induced pluripotent stem (iPS) cells, and to establish effective transplantation techniques with clinical application as the goal. The hypothalamic-pituitary system is essential for maintaining life and for controlling systemic homeostasis, but is negatively affected by various diseases, resulting in serious symptoms. For replicating the complex and precise control of the hypothalamic-pituitary system, there are hopes for regenerative medicine using pluripotent cells. We have previously established techniques for preparing hypothalamic vasopressin cells and anterior pituitary tissue from murine embryonic stem cells. Now we are trying to develop techniques for producing such cells from human iPS cells; to establish transplantation techniques; to carry out preclinical research with disease-model mammals; and to demonstrate the efficacy of transplantation, making progress toward clinical application.

6. Regulatory Mechanism of Energy Balance
 Homeostatic regulation maintains our body weight constant. Dysregulation of homeostasis for body weight leads to obesity or emaciation. Although obesity, causing lifestyle-related diseases, already spreads at the pandemic level in the world, an effective medical treatment for obesity remains to be settled. Therefore, it is warranted to elucidate the pathogenesis of obesity, and to establish a method of treatment for obesity. We research the molecular mechanism in the pathogenesis of obesity by using Cre-lox system and hypothalamic organotypic cultures maintaining the intrinsic properties in vivo.

7. Analysis of Mechanisms of Hormone Secretion from Enteroendocrine and Pancreatic Endocrine Cells by Nutrition and the Role of these Hormones in Glucose Metabolism
 Glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) are incretin hormones secreted from enteroendocrine cells by nutrients such as glucose to stimulate insulin secretion from pancreatic beta-cells. Glucagon secreted from pancreatic alpha-cells increases blood glucose levels, counterbalancing the action of insulin. We are now investigating the mechanisms for sensing nutrients, especially the monosaccharides glucose and fructose, in enteroendocrine cells and pancreatic endocrine cells using several lines of genetically modified mice.

8. Clinical Study of Obesity and Diabetes
 To elucidate pathophysiology of type 1 diabetes, we have been performing a large-scale registry study. We have also been working on IoT and AI techniques, which could be beneficial for patients with type 2 diabetes and obesity.

Faculty Members

FacultyPositionDepartment
ARIMA, Hiroshi Professor Endocrinology and Diabetes
BANNO, Ryoichi Lecturer Endocrinology and Diabetes
SUGA, Hidetaka Lecturer Endocrinology and Diabetes
GOTO, Motomitsu Lecturer of Hospital Endocrinology and Diabetes
IWAMA, Shintaro Designated Lecturer Sports Medicine
SEINO, Yusuke Assistant Professor Endocrinology and Diabetes
TAKAGI, Hiroshi Assistant Professor Endocrinology and Diabetes
MORISHITA, Yoshiaki Designated Assistant Professor Endocrinology and Diabetes
ITO, Yoshihiro Designated Assistant Professor Department of CKD Initiatives
TSUNEKAWA, Taku Assistant Professor of Hospital Endocrinology and Diabetes
ONOUE, Takeshi Assistant Professor of Hospital Endocrinology and Diabetes

Bibliography

  • 2016
    1. Fujisawa H, Sugimura Y, Takagi H, Mizoguchi H, Takeuchi H, Izumida H, Nakashima K, Ochiai H, Takeuchi S, Kiyota A, Fukumoto K, Iwama S, Takagishi Y, Hayashi Y, Arima H, Komatsu Y, Murata Y, Oiso Y. Chronic Hyponatremia Causes Neurologic and Psychologic Impairments. J Am Soc Nephrol, 2016; 27: 766-780.
    2. Iida A, Seino Y, Fukami A, Maekawa R, Yabe D, Shimizu S, Kinoshita K, Takagi Y, Izumoto T, Ogata H, Ishikawa K, Ozaki N, Tsunekawa S, Hamada Y, Oiso Y, Arima H, Hayashi Y. Endogenous GIP ameliorates impairment of insulin secretion in proglucagon-deficient mice under moderate beta cell damage induced by streptozotocin. Diabetologia, 2016; 59: 1533-1541.
    3. Izumida H, Takagi H, Fujisawa H, Iwata N, Nakashima K, Takeuchi S, Iwama S, Namba T, Komatu Y, Kaibuchi K, Oiso Y, Arima H, Sugimura Y. NMDA receptor antagonist prevents cell death in the hippocampal dentate gyrus induced by hyponatremia accompanying adrenal insufficiency in rats. Exp Neurol, 2016.
    4. Lu W, Hagiwara D, Morishita Y, Tochiya M, Azuma Y, Suga H, Goto M, Banno R, Sugimura Y, Oyadomari S, Mori K, Arima H. Unfolded protein response in hypothalamic cultures of wild-type and ATF6alpha-knockout mice. Neurosci Lett, 2016; 612: 199-203.
    5. Onoue T, Goto M, Tominaga T, Sugiyama M, Tsunekawa T, Hagiwara D, Banno R, Suga H, Sugimura Y, Arima H. Reactive oxygen species mediate insulin signal transduction in mouse hypothalamus. Neurosci Lett, 2016; 619: 1-7.
    6. Shibata M, Banno R, Sugiyama M, Tominaga T, Onoue T, Tsunekawa T, Azuma Y, Hagiwara D, Lu W, Ito Y, Goto M, Suga H, Sugimura Y, Oiso Y, Arima H. AgRP Neuron-Specific Deletion of Glucocorticoid Receptor Leads to Increased Energy Expenditure and Decreased Body Weight in Female Mice on a High-Fat Diet. Endocrinology, 2016; 157: 1457-1466.
    7. Takeuchi S, Iwama S, Takagi H, Kiyota A, Nakashima K, Izumida H, Fujisawa H, Iwata N, Suga H, Watanabe T, Kaibuchi K, Oiso Y, Arima H, Sugimura Y. Tomosyn Negatively Regulates Arginine Vasopressin Secretion in Embryonic Stem Cell-Derived Neurons. PLoS One, 2016; 11: e0164544.
    8. Ozone C, Suga H, Eiraku M, Kadoshima T, Yonemura S, Takata N, Oiso Y, Tsuji T, Sasai Y. Functional anterior pituitary generated in self-organizing culture of human embryonic stem cells. Nat Commun, 2016; 7: 10351.
    9. Seino Y, Maekawa R, Ogata H, Hayashi Y. Carbohydrate-induced secretion of glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1. J Diabetes Investig, 2016; 7 Suppl 1: 27-32.
    10. Ji S, Tokizane K, Ohkawa Y, Ohmi Y, Banno R, Okajima T, Kiyama H, Furukawa K, Furukawa K. Increased a-series gangliosides positively regulate leptin/Ob receptor-mediated signals in hypothalamus of GD3 synthase-deficient mice. Biochem Biophys Res Commun, 2016; 479: 453-460.
  • 2015
    1. Iwama S, Sugimura Y, Kiyota A, Kato T, Enomoto A, Suzuki H, Iwata N, Takeuchi S, Nakashima K, Takagi H, Izumida H, Ochiai H, Fujisawa H, Suga H, Arima H, Shimoyama Y, Takahashi M, Nishioka H, Ishikawa SE, Shimatsu A, Caturegli P, Oiso Y. Rabphilin-3A as a Targeted Autoantigen in Lymphocytic Infundibulo-neurohypophysitis. J Clin Endocrinol Metab, 2015; 100: E946-954.
    2. Izumoto-Akita T, Tsunekawa S, Yamamoto A, Uenishi E, Ishikawa K, Ogata H, Iida A, Ikeniwa M, Hosokawa K, Niwa Y, Maekawa R, Yamauchi Y, Seino Y, Hamada Y, Hibi H, Arima H, Ueda M, Oiso Y. Secreted factors from dental pulp stem cells improve glucose intolerance in streptozotocin-induced diabetic mice by increasing pancreatic beta-cell function. BMJ Open Diabetes Res Care, 2015; 3: e000128.
    3. Kataoka Y, Nishida S, Hirakawa A, Oiso Y, Arima H. Comparison of incidence of hyponatremia between intranasal and oral desmopressin in patients with central diabetes insipidus. Endocr J, 2015; 62: 195-200.
    4. Kiyota A, Iwama S, Sugimura Y, Takeuchi S, Takagi H, Iwata N, Nakashima K, Suzuki H, Nishioka T, Kato T, Enomoto A, Arima H, Kaibuchi K, Oiso Y. Identification of the novel autoantigen candidate Rab GDP dissociation inhibitor alpha in isolated adrenocorticotropin deficiency. Endocr J, 2015; 62: 153-160.
    5. Niwa Y, Ishikawa K, Ishigami M, Honda T, Achiwa K, Izumoto T, Maekawa R, Hosokawa K, Iida A, Seino Y, Hamada Y, Goto H, Oiso Y, Arima H, Tsunekawa S. Effect of hyperglycemia on hepatocellular carcinoma development in diabetes. Biochem Biophys Res Commun, 2015; 463: 344-350.
    6. Ochiai H, Suga H, Yamada T, Sakakibara M, Kasai T, Ozone C, Ogawa K, Goto M, Banno R, Tsunekawa S, Sugimura Y, Arima H, Oiso Y. BMP4 and FGF strongly induce differentiation of mouse ES cells into oral ectoderm. Stem Cell Res, 2015; 15: 290-298.
    7. Takahashi A, Lee RX, Iwasato T, Itohara S, Arima H, Bettler B, Miczek KA, Koide T. Glutamate input in the dorsal raphe nucleus as a determinant of escalated aggression in male mice. J Neurosci, 2015; 35: 6452-6463.
    8. Ishikawa K, Tsunekawa S, Ikeniwa M, Izumoto T, Iida A, Ogata H, Uenishi E, Seino Y, Ozaki N, Sugimura Y, Hamada Y, Kuroda A, Shinjo K, Kondo Y, Oiso Y. Long-term pancreatic beta cell exposure to high levels of glucose but not palmitate induces DNA methylation within the insulin gene promoter and represses transcriptional activity. PLoS One, 2015; 10: e0115350.
    9. Seino Y, Ogata H, Maekawa R, Izumoto T, Iida A, Harada N, Miki T, Seino S, Inagaki N, Tsunekawa S, Oiso Y, Hamada Y. Fructose induces glucose-dependent insulinotropic polypeptide, glucagon-like peptide-1 and insulin secretion: Role of adenosine triphosphate-sensitive K(+) channels. J Diabetes Investig, 2015; 6: 522-526.
    10. Ji S, Ohkawa Y, Tokizane K, Ohmi Y, Banno R, Furukawa K, Kiyama H, Furukawa K. b-Series gangliosides crucially regulate leptin secretion in adipose tissues. Biochem Biophys Res Commun, 2015; 459: 189-195.
  • 2014
    1. Adachi K, Goto M, Onoue T, Tsunekawa T, Shibata M, Hagimoto S, Ito Y, Banno R, Suga H, Sugimura Y, Oiso Y, Arima H. Mitogen-activated protein kinase phosphatase 1 negatively regulates MAPK signaling in mouse hypothalamus. Neurosci Lett, 2014; 569: 49-54.
    2. Arima H, Morishita Y, Hagiwara D, Hayashi M, Oiso Y. Endoplasmic reticulum stress in vasopressin neurons of familial diabetes insipidus model mice: aggregate formation and mRNA poly(A) tail shortening. Exp Physiol, 2014; 99: 66-71.
    3. Arima H, Wakabayashi T, Nagatani T, Fujii M, Hirakawa A, Murase T, Yambe Y, Yamada T, Yamakawa F, Yamamori I, Yamauchi M, Oiso Y. Adipsia increases risk of death in patients with central diabetes insipidus. Endocr J, 2014; 61: 143-148.
    4. Azuma Y, Hagiwara D, Lu W, Morishita Y, Suga H, Goto M, Banno R, Sugimura Y, Oyadomari S, Mori K, Shiota A, Asai N, Takahashi M, Oiso Y, Arima H. Activating transcription factor 6alpha is required for the vasopressin neuron system to maintain water balance under dehydration in male mice. Endocrinology, 2014; 155: 4905-4914.
    5. Hagiwara D, Arima H, Morishita Y, Wenjun L, Azuma Y, Ito Y, Suga H, Goto M, Banno R, Sugimura Y, Shiota A, Asai N, Takahashi M, Oiso Y. Arginine vasopressin neuronal loss results from autophagy-associated cell death in a mouse model for familial neurohypophysial diabetes insipidus. Cell Death Dis, 2014; 5: e1148.
    6. Takagi H, Sugimura Y, Suzuki H, Iwama S, Izumida H, Fujisawa H, Ogawa K, Nakashima K, Ochiai H, Takeuchi S, Kiyota A, Suga H, Goto M, Banno R, Arima H, Oiso Y. Minocycline prevents osmotic demyelination associated with aquaresis. Kidney Int, 2014; 86: 954-964.
    7. Kato J, Kamiya H, Himeno T, Shibata T, Kondo M, Okawa T, Fujiya A, Fukami A, Uenishi E, Seino Y, Tsunekawa S, Hamada Y, Naruse K, Oiso Y, Nakamura J. Mesenchymal stem cells ameliorate impaired wound healing through enhancing keratinocyte functions in diabetic foot ulcerations on the plantar skin of rats. J Diabetes Complications, 2014; 28: 588-595.
    8. Okawa T, Kamiya H, Himeno T, Seino Y, Tsunekawa S, Hayashi Y, Harada N, Yamada Y, Inagaki N, Seino Y, Oiso Y, Nakamura J. Sensory and motor physiological functions are impaired in gastric inhibitory polypeptide receptor-deficient mice. J Diabetes Investig, 2014; 5: 31-37.
    9. Fujiya A, Nagasaki H, Seino Y, Okawa T, Kato J, Fukami A, Himeno T, Uenishi E, Tsunekawa S, Kamiya H, Nakamura J, Oiso Y, Hamada Y. The role of S100B in the interaction between adipocytes and macrophages. Obesity (Silver Spring), 2014; 22: 371-379.
    10. Ogata H, Seino Y, Harada N, Iida A, Suzuki K, Izumoto T, Ishikawa K, Uenishi E, Ozaki N, Hayashi Y, Miki T, Inagaki N, Tsunekawa S, Hamada Y, Seino S, Oiso Y. KATP channel as well as SGLT1 participates in GIP secretion in the diabetic state. J Endocrinol, 2014; 222: 191-200.
  • 2013
    1. Arima H, Oiso Y, Juul KV, Norgaard JP. Efficacy and safety of desmopressin orally disintegrating tablet in patients with central diabetes insipidus: results of a multicenter open-label dose-titration study. Endocr J, 2013; 60: 1085-1094.
    2. Hagimoto S, Arima H, Adachi K, Ito Y, Suga H, Sugimura Y, Goto M, Banno R, Oiso Y. Expression of neuropeptide Y and agouti-related protein mRNA stimulated by glucocorticoids is attenuated via NF-kappaB p65 under ER stress in mouse hypothalamic cultures. Neurosci Lett, 2013; 553: 165-169.
    3. Ito Y, Banno R, Shibata M, Adachi K, Hagimoto S, Hagiwara D, Ozawa Y, Goto M, Suga H, Sugimura Y, Bettler B, Oiso Y, Arima H. GABA type B receptor signaling in proopiomelanocortin neurons protects against obesity, insulin resistance, and hypothalamic inflammation in male mice on a high-fat diet. J Neurosci, 2013; 33: 17166-17173.
    4. Hamada Y, Nagasaki H, Fuchigami M, Furuta S, Seino Y, Nakamura J, Oiso Y. The alpha-glucosidase inhibitor miglitol affects bile acid metabolism and ameliorates obesity and insulin resistance in diabetic mice. Metabolism, 2013; 62: 734-742.
    5. Okawa T, Kamiya H, Himeno T, Kato J, Seino Y, Fujiya A, Kondo M, Tsunekawa S, Naruse K, Hamada Y, Ozaki N, Cheng Z, Kito T, Suzuki H, Ito S, Oiso Y, Nakamura J, Isobe K. Transplantation of neural crest-like cells derived from induced pluripotent stem cells improves diabetic polyneuropathy in mice. Cell Transplant, 2013; 22: 1767-1783.
    6. Fukami A, Seino Y, Ozaki N, Yamamoto M, Sugiyama C, Sakamoto-Miura E, Himeno T, Takagishi Y, Tsunekawa S, Ali S, Drucker DJ, Murata Y, Seino Y, Oiso Y, Hayashi Y. Ectopic expression of GIP in pancreatic beta-cells maintains enhanced insulin secretion in mice with complete absence of proglucagon-derived peptides. Diabetes, 2013; 62: 510-518.
    7. Okawa T, Tsunekawa S, Seino Y, Hamada Y, Oiso Y. Deceptive HbA(1)c in a patient with pure red cell aplasia. Lancet, 2013; 382: 366.
    8. Hayashi M, Kataoka Y, Sugimura Y, Kato F, Fukami M, Ogata T, Homma K, Hasegawa T, Oiso Y, Sasano H, Tanaka H. A 68-year-old phenotypically male patient with 21-hydroxylase deficiency and concomitant adrenocortical neoplasm producing testosterone and cortisol. Tohoku J Exp Med, 2013; 231: 75-84.
  • 2012
    1. Hagiwara D, Arima H, Morishita Y, Goto M, Banno R, Sugimura Y, Oiso Y. BiP mRNA expression is upregulated by dehydration in vasopressin neurons in the hypothalamus in mice. Peptides, 2012; 33: 346-350.
    2. Ito Y, Banno R, Hagimoto S, Ozawa Y, Arima H, Oiso Y. TNFalpha increases hypothalamic PTP1B activity via the NFkappaB pathway in rat hypothalamic organotypic cultures. Regul Pept, 2012; 174: 58-64.
    3. Mizutani N, Ozaki N, Seino Y, Fukami A, Sakamoto E, Fukuyama T, Sugimura Y, Nagasaki H, Arima H, Oiso Y. Reduction of insulin signaling upregulates angiopoietin-like protein 4 through elevated free fatty acids in diabetic mice. Exp Clin Endocrinol Diabetes, 2012; 120: 139-144.
    4. Nagasaki H, Kondo T, Fuchigami M, Hashimoto H, Sugimura Y, Ozaki N, Arima H, Ota A, Oiso Y, Hamada Y. Inflammatory changes in adipose tissue enhance expression of GPR84, a medium-chain fatty acid receptor: TNFalpha enhances GPR84 expression in adipocytes. FEBS Lett, 2012; 586: 368-372.
    5. Ozawa Y, Arima H, Banno R, Ito Y, Goto M, Morishita Y, Sugimura Y, Ozaki N, Nagasaki H, Oiso Y. Lesion of area postrema attenuated hyperphagic responses to glucoprivation, but not transcriptional activation of the neuropeptide Y gene in rats. Neuroreport, 2012; 23: 673-675.
    6. Sakamoto E, Seino Y, Fukami A, Mizutani N, Tsunekawa S, Ishikawa K, Ogata H, Uenishi E, Kamiya H, Hamada Y, Sato H, Harada N, Toyoda Y, Miwa I, Nakamura J, Inagaki N, Oiso Y, Ozaki N. Ingestion of a moderate high-sucrose diet results in glucose intolerance with reduced liver glucokinase activity and impaired glucagon-like peptide-1 secretion. J Diabetes Investig, 2012; 3: 432-440.
    7. Watanabe C, Seino Y, Miyahira H, Yamamoto M, Fukami A, Ozaki N, Takagishi Y, Sato J, Fukuwatari T, Shibata K, Oiso Y, Murata Y, Hayashi Y. Remodeling of hepatic metabolism and hyperaminoacidemia in mice deficient in proglucagon-derived peptides. Diabetes, 2012; 61: 74-84.
  • 2011
    1. Iwama S, Sugimura Y, Suzuki H, Suzuki H, Murase T, Ozaki N, Nagasaki H, Arima H, Murata Y, Sawada M, Oiso Y. Time-dependent changes in proinflammatory and neurotrophic responses of microglia and astrocytes in a rat model of osmotic demyelination syndrome. Glia, 2011; 59: 452-462.
    2. Morishita Y, Arima H, Hiroi M, Hayashi M, Hagiwara D, Asai N, Ozaki N, Sugimura Y, Nagasaki H, Shiota A, Takahashi M, Oiso Y. Poly(A) tail length of neurohypophysial hormones is shortened under endoplasmic reticulum stress. Endocrinology, 2011; 152: 4846-4855.
    3. Ozawa Y, Arima H, Watanabe M, Shimizu H, Ito Y, Banno R, Sugimura Y, Ozaki N, Nagasaki H, Oiso Y. Repeated glucoprivation delayed hyperphagic responses while activating neuropeptide Y neurons in rats. Peptides, 2011; 32: 763-769.
    4. Himeno T, Kamiya H, Naruse K, Harada N, Ozaki N, Seino Y, Shibata T, Kondo M, Kato J, Okawa T, Fukami A, Hamada Y, Inagaki N, Seino Y, Drucker DJ, Oiso Y, Nakamura J. Beneficial effects of exendin-4 on experimental polyneuropathy in diabetic mice. Diabetes, 2011; 60: 2397-2406.
  • 2010
    1. Arima H, Oiso Y. Positive effect of baclofen on body weight reduction in obese subjects: a pilot study. Intern Med, 2010; 49: 2043-2047.
    2. Arima H, Oiso Y. Mechanisms underlying progressive polyuria in familial neurohypophysial diabetes insipidus. J Neuroendocrinol, 2010; 22: 754-757.
    3. Hiroi M, Morishita Y, Hayashi M, Ozaki N, Sugimura Y, Nagasaki H, Shiota A, Oiso Y, Arima H. Activation of vasopressin neurons leads to phenotype progression in a mouse model for familial neurohypophysial diabetes insipidus. Am J Physiol Regul Integr Comp Physiol, 2010; 298: R486-493.
    4. Kawada K, Kitagawa K, Kamei S, Inada M, Mitsuma A, Sawaki M, Kikumori T, Fujimoto Y, Arima H, Imai T, Ando Y. The feasibility study of docetaxel in patients with anaplastic thyroid cancer. Jpn J Clin Oncol, 2010; 40: 596-599.
    5. Shimizu H, Arima H, Ozawa Y, Watanabe M, Banno R, Sugimura Y, Ozaki N, Nagasaki H, Oiso Y. Glucocorticoids increase NPY gene expression in the arcuate nucleus by inhibiting mTOR signaling in rat hypothalamic organotypic cultures. Peptides, 2010; 31: 145-149.
    6. Suzuki H, Sugimura Y, Iwama S, Suzuki H, Nobuaki O, Nagasaki H, Arima H, Sawada M, Oiso Y. Minocycline prevents osmotic demyelination syndrome by inhibiting the activation of microglia. J Am Soc Nephrol, 2010; 21: 2090-2098.
    7. Umeda H, Ozaki N, Mizutani N, Fukuyama T, Nagasaki H, Arima H, Oiso Y. Protective effect of hedgehog signaling on cytokine-induced cytotoxicity in pancreatic beta-cells. Exp Clin Endocrinol Diabetes, 2010; 118: 692-698.
    8. Yokota F, Arima H, Hirano M, Uchikawa T, Inden Y, Nagatani T, Oiso Y. Normalisation of plasma growth hormone levels improved cardiac dysfunction due to acromegalic cardiomyopathy with severe fibrosis. BMJ Case Rep, 2010; 2010.
  • 2009
    1. Arima H, Imamine R, Oiso Y. Ping-pong champion with adrenal insufficiency. BMJ Case Rep, 2009; 2009.
    2. Hayashi M, Arima H, Ozaki N, Morishita Y, Hiroi M, Ozaki N, Nagasaki H, Kinoshita N, Ueda M, Shiota A, Oiso Y. Progressive polyuria without vasopressin neuron loss in a mouse model for familial neurohypophysial diabetes insipidus. Am J Physiol Regul Integr Comp Physiol, 2009; 296: R1641-1649.
    3. Imamine R, Arima H, Kusakabe M, Umeda H, Sato I, Homma K, Usui T, Oiso Y. Genetic analysis of two Japanese patients with non-classical 21-hydroxylase deficiency. Intern Med, 2009; 48: 705-709.
    4. Iwama S, Sugimura Y, Murase T, Hiroi M, Goto M, Hayashi M, Arima H, Oiso Y. Central adiponectin functions to inhibit arginine vasopressin release in conscious rats. J Neuroendocrinol, 2009; 21: 753-759.
    5. Suzuki C, Nagasaki H, Okajima Y, Suga H, Ozaki N, Arima H, Iwasaki Y, Oiso Y. Inflammatory cytokines regulate glycoprotein subunit beta5 of thyrostimulin through nuclear factor-kappaB. Endocrinology, 2009; 150: 2237-2243.
    6. Watanabe M, Arima H, Ozawa Y, Goto M, Shimizu H, Banno R, Sugimura Y, Ozaki N, Nagasaki H, Oiso Y. The medial hypothalamus is required for the feeding response to glucoprivation but not to food deprivation. Neurosci Lett, 2009; 464: 6-9.
    7. Oyama K, Sugimura Y, Murase T, Uchida A, Hayasaka S, Oiso Y, Murata Y. Folic acid prevents congenital malformations in the offspring of diabetic mice. Endocr J, 2009; 56: 29-37.
    8. Sugimura Y, Murase T, Kobayashi K, Oyama K, Hayasaka S, Kanou Y, Oiso Y, Murata Y. Alpha-lipoic acid reduces congenital malformations in the offspring of diabetic mice. Diabetes Metab Res Rev, 2009; 25: 287-294.
    9. Sugimura Y, Murase T, Oyama K, Uchida A, Sato N, Hayasaka S, Kano Y, Takagishi Y, Hayashi Y, Oiso Y, Murata Y. Prevention of neural tube defects by loss of function of inducible nitric oxide synthase in fetuses of a mouse model of streptozotocin-induced diabetes. Diabetologia, 2009; 52: 962-971.
  • 2008
    1. Okajima Y, Nagasaki H, Suzuki C, Suga H, Ozaki N, Arima H, Hamada Y, Civelli O, Oiso Y. Biochemical roles of the oligosaccharide chains in thyrostimulin, a heterodimeric hormone of glycoprotein hormone subunits alpha 2 (GPA2) and beta 5 (GPB5). Regul Pept, 2008; 148: 62-67.
    2. Shimizu H, Arima H, Watanabe M, Goto M, Banno R, Sato I, Ozaki N, Nagasaki H, Oiso Y. Glucocorticoids increase neuropeptide Y and agouti-related peptide gene expression via adenosine monophosphate-activated protein kinase signaling in the arcuate nucleus of rats. Endocrinology, 2008; 149: 4544-4553.
    3. Suga H, Nagasaki H, Kondo TA, Okajima Y, Suzuki C, Ozaki N, Arima H, Yamamoto T, Ozaki N, Akai M, Sato A, Uozumi N, Inoue M, Hasegawa M, Oiso Y. Novel treatment for lithium-induced nephrogenic diabetes insipidus rat model using the Sendai-virus vector carrying aquaporin 2 gene. Endocrinology, 2008; 149: 5803-5810.
    4. Watanabe M, Arima H, Fukushima K, Goto M, Shimizu H, Hayashi M, Banno R, Sato I, Ozaki N, Nagasaki H, Oiso Y. Direct and indirect modulation of neuropeptide Y gene expression in response to hypoglycemia in rat arcuate nucleus. FEBS Lett, 2008; 582: 3632-3638.
  • 2007
    1. Banno R, Arima H, Hayashi M, Goto M, Watanabe M, Sato I, Ozaki N, Nagasaki H, Ozaki N, Oiso Y. Central administration of melanocortin agonist increased insulin sensitivity in diet-induced obese rats. FEBS Lett, 2007; 581: 1131-1136.
    2. Goto M, Arima H, Hiroi M, Shimizu H, Watanabe M, Hayashi M, Banno R, Sato I, Ozaki N, Nagasaki H, Oiso Y. Insulin is not a prerequisite for rapid regulation of neuropeptide Y gene transcription in the arcuate nucleus in food-restricted rats. Neurosci Lett, 2007; 420: 61-65.
    3. Sato I, Arima H, Ozaki N, Ozaki N, Watanabe M, Goto M, Shimizu H, Hayashi M, Banno R, Nagasaki H, Oiso Y. Peripherally administered baclofen reduced food intake and body weight in db/db as well as diet-induced obese mice. FEBS Lett, 2007; 581: 4857-4864.
    4. Suzuki C, Nagasaki H, Okajima Y, Suga H, Arima H, Iwasaki Y, Oiso Y. The LIM domain homeobox gene isl-1 is a positive regulator of glycoprotein alpha 2 (GPA2), a subunit of thyrostimulin. Regul Pept, 2007; 142: 60-67.
    5. Takefuji S, Murase T, Sugimura Y, Takagishi Y, Hayasaka S, Oiso Y, Murata Y. Role of microglia in the pathogenesis of osmotic-induced demyelination. Exp Neurol, 2007; 204: 88-94.
  • 2006
    1. Goto M, Arima H, Watanabe M, Hayashi M, Banno R, Sato I, Nagasaki H, Oiso Y. Ghrelin increases neuropeptide Y and agouti-related peptide gene expression in the arcuate nucleus in rat hypothalamic organotypic cultures. Endocrinology, 2006; 147: 5102-5109.
    2. Hayashi M, Arima H, Goto M, Banno R, Watanabe M, Sato I, Nagasaki H, Oiso Y. Vasopressin gene transcription increases in response to decreases in plasma volume, but not to increases in plasma osmolality, in chronically dehydrated rats. Am J Physiol Endocrinol Metab, 2006; 290: E213-217.
    3. Murase T, Sugimura Y, Takefuji S, Oiso Y, Murata Y. Mechanisms and therapy of osmotic demyelination. Am J Med, 2006; 119: S69-73.
  • 2005
    1. Sato I, Arima H, Ozaki N, Watanabe M, Goto M, Hayashi M, Banno R, Nagasaki H, Oiso Y. Insulin inhibits neuropeptide Y gene expression in the arcuate nucleus through GABAergic systems. J Neurosci, 2005; 25: 8657-8664.
    2. Sugimura Y, Murase T, Takefuji S, Hayasaka S, Takagishi Y, Oiso Y, Murata Y. Protective effect of dexamethasone on osmotic-induced demyelination in rats. Exp Neurol, 2005; 192: 178-183
  • 2004
    1. Banno R, Arima H, Sato I, Hayashi M, Goto M, Sugimura Y, Murase T, Oiso Y. The melanocortin agonist melanotan II increases insulin sensitivity in OLETF rats. Peptides, 2004; 25: 1279-1286.
    2. Ishizaki S, Murase T, Sugimura Y, Banno R, Arima H, Miura Y, Oiso Y. Leukemia inhibitory factor stimulates vasopressin release in rats. Neurosci Lett, 2004; 359: 77-80.
    3. Kondo N, Arima H, Banno R, Kuwahara S, Sato I, Oiso Y. Osmoregulation of vasopressin release and gene transcription under acute and chronic hypovolemia in rats. Am J Physiol Endocrinol Metab, 2004; 286: E337-346.
  • 2003
    1. Kuwahara S, Arima H, Banno R, Sato I, Kondo N, Oiso Y. Regulation of vasopressin gene expression by cAMP and glucocorticoids in parvocellular neurons of the paraventricular nucleus in rat hypothalamic organotypic cultures. J Neurosci, 2003; 23: 10231-10237.
    2. Sugimura Y, Murase T, Ishizaki S, Tachikawa K, Arima H, Miura Y, Usdin TB, Oiso Y. Centrally administered tuberoinfundibular peptide of 39 residues inhibits arginine vasopressin release in conscious rats. Endocrinology, 2003; 144: 2791-2796.
    3. Tachikawa K, Yokoi H, Nagasaki H, Arima H, Murase T, Sugimura Y, Miura Y, Hirabayashi M, Oiso Y. Altered cardiovascular regulation in arginine vasopressin-overexpressing transgenic rat. Am J Physiol Endocrinol Metab, 2003; 285: E1161-1166.
  • 2002
    1. Ishizaki S, Murase T, Sugimura Y, Kakiya S, Yokoi H, Tachikawa K, Arima H, Miura Y, Oiso Y. Role of ghrelin in the regulation of vasopressin release in conscious rats. Endocrinology, 2002; 143: 1589-1593.
    2. Nagasaki H, Yokoi H, Arima H, Hirabayashi M, Ishizaki S, Tachikawa K, Murase T, Miura Y, Oiso Y. Overexpression of vasopressin in the rat transgenic for the metallothionein-vasopressin fusion gene. J Endocrinol, 2002; 173: 35-44.
    3. Yambe Y, Arima H, Kakiya S, Murase T, Oiso Y. Diurnal changes in arginine vasopressin gene transcription in the rat suprachiasmatic nucleus. Brain Res Mol Brain Res, 2002; 104: 132-136.
    4. Yokoi H, Nagasaki H, Tachikawa K, Arima H, Murase T, Miura Y, Hirabayashi M, Oiso Y. Adaptation to sustained high plasma vasopressin in water and electrolyte homeostasis in the rat transgenic for the metallothionein-vasopressin fusion gene. J Endocrinol, 2002; 173: 23-33.
  • 2000
    1. Kakiya S, Arima H, Yokoi H, Murase T, Yambe Y, Oiso Y. Effects of acute hypotensive stimuli on arginine vasopressin gene transcription in the rat hypothalamus. Am J Physiol Endocrinol Metab, 2000; 279: E886-892.
    2. Kakiya S, Murase T, Arima H, Yokoi H, Iwasaki Y, Miura Y, Oiso Y. Role of endogenous nociceptin in the regulation of arginine vasopressin release in conscious rats. Endocrinology, 2000; 141: 4466-4471.
    3. Yambe Y, Watanabe-Tomita Y, Kakiya S, Yokoi H, Nagasaki H, Arima H, Murase T, Yuasa H, Kondo K, Yamashita H, Oiso Y. Analysis of the vasopressin system and water regulation in genetically polydipsic mice. Am J Physiol Endocrinol Metab, 2000; 278: E189-194.
  • 1999
    1. Arima H, Kondo K, Kakiya S, Nagasaki H, Yokoi H, Yambe Y, Murase T, Iwasaki Y, Oiso Y. Rapid and sensitive vasopressin heteronuclear RNA responses to changes in plasma osmolality. J Neuroendocrinol, 1999; 11: 337-341.
  • 1998
    1. Arima H, Kondo K, Murase T, Yokoi H, Iwasaki Y, Saito H, Oiso Y. Regulation of vasopressin synthesis and release by area postrema in rats. Endocrinology, 1998; 139: 1481-1486.
    2. Kakiya S, Yokoi H, Arima H, Iwasaki Y, Oki Y, Oiso Y. Central administration of urocortin inhibits vasopressin release in conscious rats. Neurosci Lett, 1998; 248: 144-146.
    3. Mizuno Y, Kondo K, Terashima Y, Arima H, Murase T, Oiso Y. Anorectic effect of pituitary adenylate cyclase activating polypeptide (PACAP) in rats: lack of evidence for involvement of hypothalamic neuropeptide gene expression. J Neuroendocrinol, 1998; 10: 611-616.
    4. Terashima Y, Kondo K, Inagaki A, Yokoi H, Arima H, Murase T, Iwasaki Y, Oiso Y. Age-associated decrease in response of rat aquaporin-2 gene expression to dehydration. Life Sci, 1998; 62: 873-882.
    5. Yokoi H, Arima H, Kondo K, Murase T, Iwasaki Y, Yang HY, Oiso Y. Antiserum against neuropeptide FF augments vasopressin release in conscious rats. Peptides, 1998; 19: 393-395.
  • 1996
    1. Arima H, Murase T, Kondo K, Iwasaki Y, Oiso Y. Centrally administered neuropeptide FF inhibits arginine vasopressin release in conscious rats. Endocrinology, 1996; 137: 1523-1529.
    2. Murase T, Arima H, Kondo K, Oiso Y. Neuropeptide FF reduces food intake in rats. Peptides, 1996; 17: 353-354.
    3. Yokoi H, Arima H, Murase T, Kondo K, Iwasaki Y, Oiso Y. Intracerebroventricular injection of adrenomedullin inhibits vasopressin release in conscious rats. Neurosci Lett, 1996; 216: 65-67.
  • 1995
    1. Murase T, Kondo K, Arima H, Iwasaki Y, Ito M, Miura Y, Oiso Y. The expression of pituitary adenylate cyclase-activating polypeptide (PACAP) mRNA in rat brain: possible role of endogenous PACAP in vasopressin release. Neurosci Lett, 1995; 185: 103-106.

Research Keywords

Arginine vasopressin (AVP)、 Neurohypophysial diabetes insipidus、 Hyponatremia、 Lymphocytic infundibulo-neurohypophysitis (LINH)、 Anti-rabphilin-3A antibody、 Regenerative medicine、 ES cells、 iPS cells、 Exocytosis、 Osmotic demyelination syndrome (ODS)、 Energy balance、 Type 1 diabetes、 Type 2 diabetes、 Obesity、 GIP、 GLP-1、 Insulin、 Glucagon、 Glucose、 Fructose、 KATP channel、 Endoplasmic reticulum stress

Laboratory Members

(Photographed on 13/06/2016)member.jpg