Top > Laboratories > High-Technology Application of Medicine > Pathology and Laboratory Medicine/Diagnostic Pathology

High-Technology Application of MedicinePathology and Laboratory Medicine/Diagnostic Pathology


 Research aim of our department is to clarify the pathology and pathogenesis of malignant lymphoma. The research activities of our department cover a broad range of topics in malignant lymphoma, especially EBV-positive diffuse large B-cell lymphoma, and cytotoxic T/NK-cell lymphoma.

Research Projects

  1. Clinicopathological analysis of EBV-positive lymphomas
  2. Clinicopathological analysis of mature T/NK-cell lymphoma

Faculty Members

NAKAMURA Shigeo Professor Clinical Pathohysiology/Clinical Pathology
NAKAGURO Masato Associate Professor Clinical Pathohysiology/Clinical Pathology


  • 2016
    1. Tanaka T, Yamamoto H, Elsayed AA, Satou A, Asano N, Kohno K, Kinoshita T, Niwa Y, Goto H, Nakamura S, Kato S. Clinicopathologic Spectrum of Gastrointestinal T-cell Lymphoma: Reappraisal Based on T-cell Receptor Immunophenotypes. The American Journal of Surgical Pathology, 2016; 40: 777-785.
    2. Satou A, Asano N, Kato S, Katsuya H, Ishitsuka K, Elsayed AA, Nakamura S. FoxP3-positive T cell lymphoma arising in non-HTLV1 carrier: clinicopathological analysis of 11 cases of PTCL-NOS and 2 cases of mycosis fungoides. Histopathology, 2016; 68: 1099-1108.
  • 2015
    1. Satou A, Asano N, Nakazawa A, Osumi T, Tsurusawa M, Ishiguro A, Elsayed AA, Nakamura N, Ohshima K, Kinoshita T, Nakamura S. Epstein-Barr Virus (EBV)-positive Sporadic Burkitt Lymphoma: An Age-related Lymphoproliferative Disorder? The American Journal of Surgical Pathology, 2015; 39: 227-235.
    2. Kato S, Asano N, Miyata-Takata T, Takata K, Elsayed AA, Satou A, Takahashi E, Kinoshita T, Nakamura S. T-cell Receptor (TCR) Phenotype of Nodal Epstein-Barr Virus (EBV)-positive Cytotoxic T-cell Lymphoma (CTL): A Clinicopathologic Study of 39 Cases. The American Journal of Surgical Pathology, 2015; 39: 462-471.
  • 2012
    1. Liu F, Asano N, Tatematsu A, Oyama T, Kitamura K, Suzuki K, Yamamoto K, Sakamoto N, Taniwaki M, Kinoshita T, Nakamura S. Plasmablastic lymphoma of the elderly: a clinicopathological comparison with age-related Epstein–Barr virus-associated B cell lymphoproliferative disorder. Histopathology, 2012; 61: 1183-1197.
    2. Kimura H, Ito Y, Kawabe S, Gotoh K, Takahashi Y, Kojima S, Naoe T, Esaki S, Kikuta A, Sawada A, Kawa K, Ohshima K, Nakamura S. EBV-associated T/NK-cell lymphoproliferative diseases in nonimmunocompromised hosts: prospective analysis of 108 cases. Blood, 2012; 119: 673-686.
    3. Kato S, Takahashi E, Asano N, Tanaka T, Megahed N, Kinoshita T, Nakamura S. Nodal cytotoxic molecule (CM)-positive Epstein-Barr virus (EBV)-associated peripheral T cell lymphoma (PTCL): a clinicopathological study of 26 cases. Histopathology, 2012; 61: 186-199.
  • 2011
    1. Takahashi E, Ohshima K, Kimura H, Hara K, Suzuki R, Kawa K, Eimoto T, Nakamura S. Clinicopathological analysis of the age-related differences in patients with Epstein-Barr virus (EBV)-associated extranasal natural killer (NK)/T-cell lymphoma with reference to the relationship with aggressive NK cell leukaemia and chronic active EBV infection-associated lymphoproliferative disorders. Histopathology, 2011; 59: 660-671.
    2. Asano N, Kinoshita T, Tamaru J-I, Ohshima K, Yoshino T, Niitsu N, Tsukamoto N, Hirabayashi K, Izutsu K, Taniwaki M, Morishima Y, Nakamura S. Cytotoxic molecule-positive classical Hodgkin’s lymphoma: a clinicopathological comparison with cytotoxic molecule-positive peripheral T-cell lymphoma of not otherwise specified type. Haematologica, 2011; 96: 1636-1643.
  • 2009
    1. Asano N, Yamamoto K, Tamaru J-I, Oyama T, Ishida F, Ohshima K, Yoshino T, Nakamura N, Mori S, Yoshie O, Shimoyama Y, Morishima Y, Kinoshita T, Nakamura S. Age-related Epstein-Barr virus (EBV)–associated B-cell lymphoproliferative disorders: comparison with EBV-positive classic Hodgkin lymphoma in elderly patients. Blood, 2009; 113: 2629-2636.
  • 2007
    1. Oyama T, Yamamoto K, Asano N, Oshiro A, Suzuki R, Kagami Y, Morishima Y, Takeuchi K, Izumo T, Mori S, Ohshima K, Suzumiya J, Nakamura N, Abe M, Ichimura K, Sato Y, Yoshino T, Naoe T, Shimoyama Y, Kamiya Y, Kinoshita T, Nakamura S. Age-related EBV-associated B-cell lymphoproliferative disorders constitute a distinct clinicopathologic group: a study of 96 patients. Clin Cancer Res, 2007; 13: 5124-5132.
    2. Ponzoni M, Ferreri AJM, Campo E, Facchetti F, Mazzucchelli L, Yoshino T, Murase T, Pileri SA, Doglioni C, Zucca E, Cavalli F, Nakamura S. Definition, Diagnosis, and Management of Intravascular Large B-Cell Lymphoma: Proposals and Perspectives From an International Consensus Meeting. J Clin Oncol, 2007; 25: 3168-3173.
    3. Murase T, Yamaguchi M, Suzuki R, Okamoto M, Sato Y, Tamaru J-i, Kojima M, Miura I, Mori N, Yoshino T, Nakamura S. Intravascular large B-cell lymphoma (IVLBCL): a clinicopathologic study of 96 cases with special reference to the immunophenotypic heterogeneity of CD5. Blood, 2007; 109: 478-485.
  • 2006
    1. Asano N, Oshiro A, Matsuo K, Kagami Y, Ishida F, Suzuki R, Kinoshita T, Shimoyama Y, Tamaru J-I, Yoshino T, Kitamura K, Fukutani H, Morishima Y, Nakamura S. Prognostic Significance of T-Cell or Cytotoxic Molecules Phenotype in Classical Hodgkin’s Lymphoma: A Clinicopathologic Study. J Clin Oncol, 2006; 24: 4626-4633.

Research Keywords

Surgical Pathology、 Laboratory Medicine、 Molecular Diagnostics、 Malignant lymphoma、 EBV、 cytotoxic molecule、 T-cell receptor phenotype