Introduction

Department of Nagoya University Emergency & Care Medicine provides "acute care medicine" in light of the state of “acute medical phase" such as emergency medicine and critical care in Japan and the world. The department started under the first Professor Jun Takezawa MD. PhD. in April 1995, and has been handed over from the second professor Naoyuki Matsuda MD. PhD. in February 2010. It is operated with the aim of developing "emergency medicine" and "critical care" under many types of clinical and basic researches for medical students and medical workers.

Research Projects

1. Establishment of pathology and treatment of systemic inflammatory response(SIRS, sepsis, trauma, acute pancreatitis, multiple organ failure, disseminated intravascular coagulation) (clinical and basic research)
2. Pathophysiology of acute lung injury and elucidation of novel drug discovery (ex. treatment of pulmonary fibrosis) (basic research)
3. Establishment of pathophysiology and treatment of shock and endothelial cell injury (clinical and basic research)
4. Promotion of tissue repair in septic condition (basic research)
5. Acute phase clinical nutrition (clinical and basic research)
6. Research on management of post-resuscitation encephalopathy (clinical and basic research)
7. Research on analgesia and sedation in critical care (clinical and basic research)
8. Research on the epidemiology and medical care of environmental abnormalities (heatstroke and incidental hypothermia) (clinical research)
9. Research on epidemiology and treatment of acute drug poisoning (clinical research)
10. Construction and operation of pediatric emergency care database (clinical research)
11. Research on safety management of emergency and critical care (clinical research)

Faculty Members

Faculty	Position	Department
Naoyuki Matsuda	Professor	Emergency & Critical Care Medicine
Atsushi Numaguchi	Clinical Lecturer	Emergency & Critical Care Medicine
Yukari Goto	Clinical Lecturer	Emergency & Critical Care Medicine
Takanori Yamamoto	Assistant Clinical Professor	Emergency & Critical Care Medicine
Michiko Higashi	Assistant Clinical Professor	Emergency & Critical Care Medicine
Daisuke Kasugai	Assistant Clinical Professor	Emergency & Critical Care Medicine

Bibliography

• 2018

  1. Hattori Y, Hattori K, Suzuki T, Palikhe S, Matsuda N. Nucleic-acid based gene therapy approaches for sepsis. Eur J Pharmacol. 2018;833:403-410.
  2. Imaizumi T, Matsuda N, Tomita K, Palikhe S, Ohashi W, Hattori K, Hattori Y. Activator Protein-1 Decoy Oligodeoxynucleotide Transfection Is Beneficial in Reducing Organ Injury and Mortality in Septic Mice. Crit Care Med. 2018;46:e435-e442.
  3. Takatani Y, Ono K, Suzuki H, Inaba M, Sawada M, Matsuda N. Inducible nitric oxide synthase during the late phase of sepsis is associated with hypothermia and immune cell migration. Lab Invest.  2018;98:629-639. 
  4. Kawakami M, Hattori M, Ohashi W, Fujimori T, Hattori K, Takebe M, Tomita K, Yokoo H, Matsuda N, Yamazaki M, Hattori Y. Role of G protein-coupled receptor kinase 2 in oxidative and nitrosative stress-related neurohistopathological changes in a mouse model of sepsis-associated encephalopathy.  J Neurochem. 2018;145:474-488. 
  5. Nishikimi M, Numaguchi A, Takahashi K, Miyagawa Y, Matsui K, Higashi M, Makishi G, Matsui S, Matsuda N. Effect of Administration of Ramelteon, a Melatonin Receptor Agonist, on the Duration of Stay in the ICU: A Single-Center Randomized Placebo-Controlled Trial. Crit Care Med. 2018;128:11-15. 
  6. Nishikimi M, Ogura T, Nishida K, Takahashi K, Fukaya K, Liu K, Nakamura M, Matsui S, Matsuda N. Differential effect of mild therapeutic hypothermia depending on the findings of hypoxic encephalopathy on early CT images in patients with post-cardiac arrest syndrome. Resuscitation. 2018;128:11-15.
  7. Nishikimi M, Ogura T, Matsui K, Takahashi K, Fukaya K, Liu K, Morita H, Nakamura M, Matsui S, Matsuda N. Accuracy of the first interpretation of early brain CT images for predicting the prognosis of post-cardiac arrest syndrome patients at the emergency department. J Intensive Care. 2018;6:26.
  8. Yamashita S, Suzuki T, Iguchi K, Sakamoto T, Tomita K, Yokoo H, Sakai M, Misawa H, Hattori K, Nagata T, Watanabe Y, Matsuda N, Yoshimura N, Hattori Y. Cardioprotective and functional effects of levosimendan and milrinone in mice with cecal ligation and puncture-induced sepsis. Naunyn Schmiedebergs Arch Pharmacol. 2018;391:1021-1032.
  9. Sakamoto T, Ohashi W, Tomita K, Hattori K, Matsuda N, Hattori Y. Anti-inflammatory properties of cilostazol: Its interruption of DNA binding activity of NF-κB from the Toll-like receptor signaling pathways.Int Immunopharmacol. 2018;62:120-131.
  10. Suzuki T, Sakata K, Mizuno N, Palikhe S, Yamashita S, Hattori K, Matsuda N, Hattori Y. Different involvement of the MAPK family in inflammatory regulation in human pulmonary microvascular endothelial cells stimulated with LPS and IFN-γ. Immunobiology. 2018;223:777-785.
  11. Endo S, Shimazaki R, Antithrombin Gamma Study Group. An open-label, randomized, phase 3 study of the efficacy and safety of antithrombin gamma in patients with sepsis-induced disseminated intravascular coagulation syndrome. J Intensive Care. 2018;6:75.
  12. Nishikimi M, Numaguchi A, Takahashi K, Matsui S, Matsuda N. The authors' reply. Crit Care Med. 2018;46:e1010-e1011.
  13. Nishikimi M, Numaguchi A, Takahashi K, Matsui S, Matsuda N. The authors' reply. Crit Care Med. 2018;46:e1225-e1226.
  14. Kondo T, Sawamura A, Okumura T, Kano N, Morimoto R, Watanabe N, Hiraiwa H, Kuwayama T, Sugiura Y, Haga T, Yamaguchi S, Fukaya K, Yokoi T, Fujimoto K, Mutsuga M, Yoshizumi T, Matsuda N, Usui A, Murohara T.  Promising method for management of venoarterial extracorporeal membrane oxygenation: A case of severe heart failure successfully stabilized by "high-flow/vasodilation method”. J Cardiol Cases. 2018;18:81-84.
  15. Kondo T, Morimoto R, Yokoi T, Yamaguchi S, Kuwayama T, Haga T, Hiraiwa H, Sugiura Y, Watanabe N, Kano N, Ichii T, Fukaya K, Sawamura A, Okumura T, Yoshizumi T, Mutsuga M, Fujimoto K, Matsuda N, Usui A, Murohara T. Hemodynamics of cardiac tamponade during extracorporeal membrane oxygenation support in a patient with fulminant myocarditis. J Cardiol Cases. 2018;19:22-24. 
  16. Nishida O, Ogura H, Egi M, Fujishima S, Hayashi Y, Iba T, Imaizumi H, Inoue S, Kakihana Y, Kotani J, Kushimoto S, Masuda Y, Matsuda N, Matsushima A, Nakada TA, Nakagawa S, Nunomiya S, Sadahiro T, Shime N, Yatabe T, Hara Y, Hayashida K, Kondo Y, Sumi Y, Yasuda H, Aoyama K, Azuhata T, Doi K, Doi M, Fujimura N, Fuke R, Fukuda T, Goto K, Hasegawa R, Hashimoto S, Hatakeyama J, Hayakawa M, Hifumi T, Higashibeppu N, Hirai K, Hirose T, Ide K, Kaizuka Y, Kan'o T, Kawasaki T, Kuroda H, Matsuda A, Matsumoto S, Nagae M, Onodera M, Ohnuma T, Oshima K, Saito N, Sakamoto S, Sakuraya M, Sasano M, Sato N, Sawamura A, Shimizu K, Shirai K, Takei T, Takeuchi M, Takimoto K, Taniguchi T, Tatsumi H, Tsuruta R, Yama N, Yamakawa K, Yamashita C, Yamashita K, Yoshida T, Tanaka H, Oda S. The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2016 (J-SSCG 2016). J Intensive Care. 2018;6:7. Acute Med Surg. 2018;5:3-89.

• 2017

  1. Hattori Y, Hattori K, Suzuki T, Matsuda N. Recent advances in the pathophysiology and molecular basis of sepsis-associated organ dysfunction: Novel therapeutic implications and challenges. Pharmacol Ther. 2017;177:56-66.
  2. Nishikimi M, Matsuda N, Matsui K, Takahashi K, Ejima T, Liu K, Ogura T, Higashi M, Umino H, Makishi G, Numaguchi A, Matsushima S, Tokuyama H, Nakamura M, Matsui S. A novel scoring system for predicting the neurologic prognosis prior to the initiation of induced hypothermia in cases of post-cardiac arrest syndrome: the CAST score. Scand J Trauma Resusc Emerg Med.2017;25:49.
  3. Sakai M, Suzuki T, Tomita K, Yamashita S, Palikhe S, Hattori K, Yoshimura N, Matsuda N, Hattori Y. Diminished responsiveness to dobutamine as an inotrope in mice with cecal ligation and puncture-induced sepsis: attribution to phosphodiesterase 4 upregulation. Am J Physiol Heart Circ Physiol. 2017;31:H1224-H1237.
  4. Miyamoto K, Horibe M, Sanui M, Sasaki M, Sugiyama D, Kato S, Yamashita T, Goto T, Iwasaki E, Shirai K, Oe K, Sawano H, Oda T, Yasuda H, Ogura Y, Hirose K, Kitamura K, Chiba N, Ozaki T, Oshima T, Yamamoto T, Nagata K, Mine T, Saito K, Sekino M, Furuya T, Matsuda N, Hayakawa M, Kanai T, Mayumi T. Plasmapheresis therapy has no triglyceride-lowering effect in patients with hypertriglyceridemic pancreatitis. Intensive Care Med. 2017;43:949-951.
  5. Yamamoto S, Muramatsu M, Azuma E, Ikutani M, Nagai Y, Sagara H, Koo BN, Kita S, O'Donnell E, Osawa T, Takahashi H, Takano KI, Dohmoto M, Sugimori M, Usui I, Watanabe Y, Hatakeyama N, Iwamoto T, Komuro I, Takatsu K, Tobe K, Niida S, Matsuda N, Shibuya M, Sasahara M. A subset of cerebrovascular pericytes originates from mature macrophages in the very early phase of vascular development in CNS. Sci Rep. 2017;7:3855.

• 2016

  1. Matsuda N. Alert cell strategy in SIRS-induced vasculitis: sepsis and endothelial cells. J Intensive Care  2016;4:21.
  2. Matsuda N, Yamada S, Hinoshita T, Sasaki J, Ikeda H, Harunari N, Sakamoto T. The International Activities in Taiwan by the Joint Burn Care Assistance Team of Physicians from Japan Medical Association and Three Medical Societies. Japan Med Assoc J. 59:12-16，2016.
  3. Hattori Y, Hattori K, Matsuda N. Regulation of the Cardiovascular System by Histamine. Handb Exp Pharmacol. 2016;241:239-258.
  4. Nishikimi M, Matsuda N, Matsui K, Takahashi K, Ejima T, Liu K, Ogura T, Higashi M, Umino H, Makishi G, Numaguchi A, Matsushima S, Tokuyama H, Nakamura M, Matsui S. CAST: a new score for early prediction of neurological outcomes after cardiac arrest before therapeutic hypothermia with high accuracy. Intensive Care Med 2016;42:2106-2107.
  5. Inaba M, Matsuda N, Banno H, Jin W, Wachino JI, Yamada K, Kimura K, Arakawa Y. In vitro reduction of antibacterial activity of tigecycline against multidrug-resistant Acinetobacter baumannii with host stress hormone norepinephrine. Int J Antimicrob Agents 2016;48:680-689.
  6. Hattori M, Yamazaki M, Ohashi W, Tanaka S, Hattori K, Todoroki K, Fujimori T, Ohtsu H, Matsuda N, Hattori Y. Critical role of endogenous histamine in promoting end-organ tissue injury in sepsis. Intensive Care Med Exp 2016;4:36.

Research Keywords

emergency medicine、 critical care medicine、 acute phase management、 acute lung injury、 shock、 acute kidney injury、 acute liver failure、 disseminated intravascular coagulation、 endothelial cell injury、 postresuscitation、 hypoxic encephalopathy、 environmental abnormality、 sepsis、 systemic inflammation、 intracellular signal transduction、 transcription factors.