Higher Nervous Control(Cooperating field)Immnnometabolism


Obesity may be viewed as a state of chronic, low-grade inflammation, which plays an important role in the development of the metabolic syndrome. Indeed, unbalanced production of pro- and anti-inflammatory adipocytokines observed in visceral fat obesity plays a critical role in the pathophysiology of the metabolic syndrome. Recent evidence has revealed that adipose tissue in obesity exhibits chronic inflammatory changes, thereby contributing to the pathogenesis of metabolic derangements of multiple organs. We have provided evidence on the molecular mechanisms of how obesity induces adipose tissue inflammation and how adipose tissue inflammation disturbs adipose tissue function, especially focusing on the crosstalk between adipocytes and macrophages. Understanding the role of chronic inflammation in the metabolic syndrome will lead to identification of novel therapeutic strategies to prevent or treat obesity-related diseases such as diabetes, nonalcoholic steatohepatitis, and chronic kidney disease.

Research Projects

  1. Role of chronic inflammation in the pathophysiology of the metabolic syndrome
  2. Molecular mechanism of metabolic homeostasis in response to nutritional changes
  3. Development of novel therapeutic strategies based on medicine and engineering cooperation

Faculty Members

Takayoshi SUGANAMI Professor Immunometabolism
Miyako TANAKA Assistant Professor Immunometabolism
Hiroya OTA Assistant Professor Immunometabolism


  • 2016
    1. R. Hachiya, T. Shiihashi, I. Shirakawa, Y. Iwasaki, Y. Matsumura, Y. Oishi, Y. Nakayama, Y. Miyamoto, I. Manabe, K. Ochi, M. Tanaka, N. Goda, J. Sakai, T. Suganami, Y. Ogawa. The H3K9 methyltransferase Setdb1 regulates TLR4-mediated inflammatory responses in macrophages. Sci. Rep. 6: 28845, 2016.
  • 2015
    1. K. Konuma, M. Itoh, T. Suganami, S. Kanai, N. Nakagawa, T. Sakai, H. Kawano, M. Hara, S. Kojima, Y. Izumi, Y. Ogawa. Eicosapentaenoic acid ameliorates non-alcoholic steatohepatitis in a novel mouse model using Melanocortin 4 receptor-deficient mice. PLoS ONE 10: e0121528, 2015.
    2. T. Ehara, Y. Kamei, X. Yuan, M. Takahashi, S. Kanai, K. Tsujimoto, T. Tamiya, Y. Nakagawa, H. Shimano, T. Takai-Igarashi, I. Hatada, T. Suganami, K. Hashimoto, Y. Ogawa. Ligand-activated PPARα-dependent DNA demethylation regulates the fatty acid β-oxidation genes in the postnatal liver. Diabetes 64: 775-784, 2015.
  • 2014
    1. M. Tanaka, K. Ikeda, T. Suganami, C. Komiya, K. Ochi, I. Shirakawa, M. Hamaguchi, S. Nishimura, I. Manabe, T. Matsuda, K. Kimura, H. Inoue, Y. Inagaki, S. Aoe, S. Yamasaki, Y. Ogawa. Macrophage-inducible C-type lectin underlies obesity-induced adipose tissue fibrosis. Nat. Commun. 5: 4982, 2014.
    2. Y. Iwasaki, T. Suganami, R. Hachiya, I. Shirakawa, M. Kim-Saijo, M. Tanaka, M. Hamaguchi, T. Takai-Igarashi, M. Nakai, Y. Miyamoto, Y. Ogawa. Activating transcription factor 4 links metabolic stress to interleukin-6 expression in macrophages. Diabetes 63: 152-161, 2014.
  • 2013
    1. M. Itoh, H. Kato, T. Suganami, K. Konuma, Y. Marumoto, S. Terai, H. Sakugawa, S. Kanai, M. Hamaguchi, T. Fukaishi, S. Aoe, K. Akiyoshi, Y. Komohara, M. Takeya, I. Sakaida, Y. Ogawa. Hepatic crown-like structure: a unique histological feature in non-alcoholic steatohepatitis in mice and humans. PLoS ONE 8: e82163, 2013.
  • 2012
    1. T. Ehara, Y. Kamei, M. Takahashi, X. Yuan, S. Kanai, E. Tamura, M. Tanaka, T. Yamazaki, S. Miura, O. Ezaki, T. Suganami, M. Okano, Y. Ogawa. Role of DNA methylation in the regulation of lipogenic glycerol-3-phosphate acyltransferase 1 gene expression in the mouse neonatal liver. Diabetes 61: 2442-2450, 2012.
    2. N. Satoh-Asahara, A. Shimatsu, Y. Sasaki, H. Nakaoka, A. Himeno, M. Tochiya, S. Kono, T. Takaya, K. Ono, H. Wada, T. Suganami, K. Hasegawa, Y. Ogawa. Highly purified eicosapentaenoic acid increases interleukin-10 levels of peripheral blood monocytes in obese patients with dyslipidemia. Diabetes Care 35: 2631-2639, 2012.
  • 2011
    1. M. Ichioka, T. Suganami, N. Tsuda, I. Shirakawa, Y. Hirata, N. Satoh-Asahara, Y. Shimoda, M. Tanaka, M. Kim-Saijo, Y. Miyamoto, Y. Kamei, M. Sata, Y. Ogawa. Increased expression of macrophage-inducible C-type lectin in adipose tissue of obese mice and humans. Diabetes 60: 819-826, 2011.
    2. M. Tanaka, T. Suganami, M. Kim-Saijo, C. Toda, M. Tsuiji, K. Ochi, Y. Kamei, Y. Minokoshi, Y. Ogawa. Role of central leptin signaling in the starvation-induced alteration of B cell development. J. Neurosci. 31: 8373-8380, 2011.
    3. M. Itoh, T. Suganami, N. Nakagawa, M. Tanaka, Y. Yamamoto, Y. Kamei, S. Terai, I. Sakaida, Y. Ogawa. Melanocortin-4 receptor-deficient mice as a novel mouse model of non-alcoholic steatohepatitis. Am. J. Pathol. 179: 2454-2463, 2011.

Research Keywords

Chronic inflammation、 Metabolic syndrome、 Obesity、 Nutrition、 Homeostasis、 Medicine and engineering cooperation