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Anatomy and Cell BiologyMolecular Cell Biology

Introduction

Now under updating.

Research Projects

Now under updating. 

November 2019, Dr. Hiroaki Wake became our new professor of Molecular Cell Biology. 

For the time being please refer his old laboratory website of Kobe University Graduate School of Medicine, Division of System Neuroscience.

Faculty Members

FacultyPositionDepartment
Hiroaki Wake Professor Anatomy and Molecular Cell Biology
Yuki Ohsaki Associate professor Anatomy and Molecular Cell Biology
Daisuke Kato Assistant professor Anatomy and Molecular Cell Biology

Bibliography

  • 2016
    1. Takatori S, Tatematsu T, Cheng J, Matsumoto J, Akano T, Fujimoto T. Phosphatidylinositol 3,5-Bisphosphate-Rich Membrane Domains in Endosomes and Lysosomes. Traffic, 2016; 17: 154-167.
    2. Takatori S, Fujimoto T. A novel imaging method revealed phosphatidylinositol 3,5-bisphosphate-rich domains in the endosome/lysosome membrane. Commun Integr Biol, 2016; 9: e1145319.
    3. Ohsaki Y, Kawai T, Yoshikawa Y, Cheng J, Jokitalo E, Fujimoto T. PML isoform II plays a critical role in nuclear lipid droplet formation. J Cell Biol, 2016; 212: 29-38.
  • 2015
    1. Takatori S, Fujimoto T. Microscopy of membrane lipids: how precisely can we define their distribution? Essays Biochem, 2015; 57: 81-91.
    2. Suzuki M, Murakami T, Cheng J, Kano H, Fukata M, Fujimoto T. ELMOD2 is anchored to lipid droplets by palmitoylation and regulates adipocyte triglyceride lipase recruitment. Mol Biol Cell, 2015; 26: 2333-2342.
    3. Imai N, Suzuki M, Hayashi K, Ishigami M, Hirooka Y, Abe T, Shioi G, Goto H, Fujimoto T. Hepatocyte-Specific Depletion of UBXD8 Induces Periportal Steatosis in Mice Fed a High-Fat Diet. PLoS One, 2015; 10: e0127114.
  • 2014
    1. Yamamura T, Ohsaki Y, Suzuki M, Shinohara Y, Tatematsu T, Cheng J, Okada M, Ohmiya N, Hirooka Y, Goto H, Fujimoto T. Inhibition of Niemann-Pick-type C1-like1 by ezetimibe activates autophagy in human hepatocytes and reduces mutant alpha1-antitrypsin Z deposition. Hepatology, 2014; 59: 1591-1599.
    2. Takatori S, Mesman R, Fujimoto T. Microscopic methods to observe the distribution of lipids in the cellular membrane. Biochemistry, 2014; 53: 639-653.
    3. Ohsaki Y, Suzuki M, Fujimoto T. Open questions in lipid droplet biology. Chem Biol, 2014; 21: 86-96.
    4. Iyoshi S, Cheng J, Tatematsu T, Takatori S, Taki M, Yamamoto Y, Salic A, Fujimoto T. Asymmetrical distribution of choline phospholipids revealed by click chemistry and freeze-fracture electron microscopy. ACS Chem Biol, 2014; 9: 2217-2222.
    5. Fujimoto T, Yamamoto H, Ohsumi Y. Different phosphatidylinositol 3-phosphate asymmetries in yeast and mammalian autophagosomes revealed by a new electron microscopy technique. Autophagy, 2014; 10: 933-935.
    6. Cheng J, Fujita A, Yamamoto H, Tatematsu T, Kakuta S, Obara K, Ohsumi Y, Fujimoto T. Yeast and mammalian autophagosomes exhibit distinct phosphatidylinositol 3-phosphate asymmetries. Nat Commun, 2014; 5: 3207.
  • 2013
    1. Suzuki M, Shinohara Y, Fujimoto T. Histochemical detection of lipid droplets in cultured cells. Methods Mol Biol, 2013; 931: 483-491.
    2. Suzuki M, Iio Y, Saito N, Fujimoto T. Protein kinase Ceta is targeted to lipid droplets. Histochem Cell Biol, 2013; 139: 505-511.
    3. Ohsaki Y, Cheng J, Yamairi K, Pan X, Hussain MM, Fujimoto T. Inhibition of ADP-ribosylation suppresses aberrant accumulation of lipidated apolipoprotein B in the endoplasmic reticulum. FEBS Lett, 2013; 587: 3696-3702.
    4. Fujimoto T, Ohsaki Y, Suzuki M, Cheng J. Imaging lipid droplets by electron microscopy. Methods Cell Biol, 2013; 116: 227-251.
  • 2012
    1. Suzuki M, Otsuka T, Ohsaki Y, Cheng J, Taniguchi T, Hashimoto H, Taniguchi H, Fujimoto T. Derlin-1 and UBXD8 are engaged in dislocation and degradation of lipidated ApoB-100 at lipid droplets. Mol Biol Cell, 2012; 23: 800-810.
    2. Suzuki M, Ohsaki Y, Tatematsu T, Shinohara Y, Maeda T, Cheng J, Fujimoto T. Translation inhibitors induce formation of cholesterol ester-rich lipid droplets. PLoS One, 2012; 7: e42379.
    3. Fujita A, Fujimoto T, Ozato-Sakurai N, Suzuki H. A method for efficient observation of intracellular membranes of monolayer culture cells by quick-freeze and freeze-fracture electron microscopy. J Electron Microsc (Tokyo), 2012; 61: 441-446.
  • 2011
    1. Suzuki M, Shinohara Y, Ohsaki Y, Fujimoto T. Lipid droplets: size matters. J Electron Microsc (Tokyo), 2011; 60 Suppl 1: S101-116.
    2. Ozato-Sakurai N, Fujita A, Fujimoto T. The distribution of phosphatidylinositol 4,5-bisphosphate in acinar cells of rat pancreas revealed with the freeze-fracture replica labeling method. PLoS One, 2011; 6: e23567.
    3. Fujimoto T, Parton RG. Not just fat: the structure and function of the lipid droplet. Cold Spring Harb Perspect Biol, 2011; 3.
  • 2010
    1. Ohsaki Y, Suzuki M, Shinohara Y, Fujimoto T. Lysosomal accumulation of mTOR is enhanced by rapamycin. Histochem Cell Biol, 2010; 134: 537-544.
    2. Ohsaki Y, Shinohara Y, Suzuki M, Fujimoto T. A pitfall in using BODIPY dyes to label lipid droplets for fluorescence microscopy. Histochem Cell Biol, 2010; 133: 477-480.
    3. Fujita A, Fujimoto T. High-resolution molecular localization by freeze-fracture replica labeling. Methods Mol Biol, 2010; 657: 205-216.
    4. Fujita A, Cheng J, Fujimoto T. Quantitative electron microscopy for the nanoscale analysis of membrane lipid distribution. Nat Protoc, 2010; 5: 661-669.

Research Keywords

glia cells、 neural network、 two-photon microscopy、 holographic microscopy、 lipid droplets、 membrane lipids、 electron microscopy