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Advanced Medical Science(Cooperating field)Nanoengineered Molecular Diagnosis

Introduction

Nanobiodevice is a piece of contrivance, equipment, machine, or component, which is created by the overlapping multidisciplinary activities associated with nanotechnology and biotechnology, intended for biological, medical, and clinical purposes. During the past decade, nanobiodevice has progressively begun to focus on the establishment of main four fields of biomedical applications of nanotechnology, including 1) diagnostic devices, 2) molecular imaging, 3) regenerative medicine, and 4) drug delivery systems. The research efforts in my laboratory have been focused on the development of novel nanodevices, nanomatrials, and nanotechnologies intended for biomedical applications, including genome and proteome analysis, analysis of biomolecules and cells, diagnosis of diseases, in vivo imaging, stem cell therapy, tissue engineering, and gene delivery system, as shown in Fig. 1.

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Research Projects

The research in our laboratory has been supported by Cabinet Office’s Funding Program for World-Leading Innovative R&D on Science and Technology (FIRST), Cabinet Office’s Impulsing Paradigm Change through Disruptive Technologies Program (ImPACT) (Fig. 2) and MEXT Center of Innovation

Science and Technology based Radical Innovation and Entrepreneurship Program (COI-STREAM) (Fig. 3). Since nanobiodevice has tremendous advantages, it is applicable to fast analysis of biomolecules. Nanopillar-nanopore integrated nanobiodevice enables us to develop ultarafast single molecular DNA sequencing as shown in Fig. 4 and nanowire-nanopore devices combined with machine learning technique enable us to develop mobile sensors for PM2.5, bacteria, and virus in the environment.

AMED translational research network program (Fig. 5) supports us to develop immuno-wall devices realized the fast and low invasive “from blood to analysis” type biomarker detection of cancer with fM detection sensitivity within 2 min (Fig. 6) and the synchrotron radiation based nanofabrication technology enables us to develop highly sensitive immno-wall devices supported by Aichi Prefectural Funding Program for Priority Research Area (Fig. 7).

AMED next-generation cancer diagnostic system program (Fig. 8) supports the development Nanowire devices coupled with super-resolution optical microscopy are extremely useful to analyze exosomes from cancer cells and exosomal microRNA analysis(Fig. 9).

AMED research center network for realization of regenerative medicine (Fig. 10) makes us to develop quantum-biodevices for single cancer cell diagnosis, single molecular epigenetic analysis, quantum switching in vivo imaging for iPS cell (induced pluripotent stem cells) based regenerative medicine, and theranostic devices for cancer diagnosis/therapy(Fig. 11).

(Fig.2)
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文部科学省COI-STREAM(Fig. 3)
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(Fig. 4)
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(Fig. 5)
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(Fig.6)
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(Fig. 7)
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(Fig. 8)
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(Fig. 9)
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(Fig. 10)
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(Fig. 11)
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Faculty Members

FacultyPositionDepartment
Yoshinobu Baba Professor Nanoengineered Molecular Diagnostics
Noritada Kaji Associate Professor Nanoengineered Molecular Diagnostics
Takao Yasui Assistant Professor Nanoengineered Molecular Diagnostics

Bibliography

  • 2017
    1. Y. Ogihara, H. Yukawa, T. Kameyama, H. Nishi, D. Onoshima, T. Ishikawa, T. Torimoto, Y. Baba Labeling and in vivo Visualization of Transplanted Adipose Tissue-Derived Stem Cells with Safe Cadmium-Free Aqueous ZnS coating of ZnS-AgInS2 Nanoparticles Scientific Reports, 2017, 7, Article number: 40047.
  • 2016
    1. Takao Yasui, Kensuke Ogawa, Noritada Kaji, Mats Nilsson, Taiga Ajiri, Manabu Tokeshi, Yasuhiro Horiike, and Yoshinobu Baba,Label-free detection of real-time DNA amplification using a nanofluidic diffraction grating,Scientific Reports, 2016, 31642.
  • 2004
    1. Sakon Rahong, Takao Yasui, Takeshi Yanagida, Kazuki Nagashima, Masaki Kanai, Gang Meng, Yong He, Fuwei Zhuge, Noritada Kaji, Tomoji Kawai and Yoshinobu Baba,Three-dimensional Nanowire Structures for Ultra-Fast Separation of DNA, Protein and RNA Molecules,Sci. Rep. (Nature Publishing Group), 2015, 5, 10584.
    2. Rumiana Bakalova, Zhivko Zhelev, Hideki Ohba, Mitsuru Ishikawa, Yoshinobu Baba Quantum dots as photosensitizers?Nature Biotech., 2004, 22, 1360-1361
    3. M. Tabuchi, M. Ueda, N. Kaji, Y. Yamasaki, Y. Nagasaki, K. Yoshikawa, K. Kataoka, and Y. Baba Nanospheres for DNA Separation Chips Nature Biotech., 2004, 22(3), 337-340

Research Keywords

Nanobiodevice、 molecular imaging、 molecular diagnosis、 regenerative medicine、 gene delivery systems

You are welcome to apply to our laboratory as PhD students, when you would like to investigate nanobiodevcei, molecular diagnosis, genome medicine, single molecular analysis, single cellular analysis, nanotechnology, nanomaterials for regenerative medicine, and quantum dot in vivo imaging.