研究業績

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  • Mizoguchi Y, Kitamura A, Wake H, Ishibashi H, Watanabe M, Nishimaki T, Nabekura J.

    BDNF occludes GABA receptor-mediated inhibition of GABA release in rat hippocampal CA1 pyramidal neurons.

    Eur J Neurosci. 2006 Oct;24(8):2135-44.

  • Wake H, Watanabe M, Moorhouse AJ, Kanematsu T, Horibe S, Matsukawa N, Asai K, Ojika K, Hirata M, Nabekura J.

    Early changes in KCC2 phosphorylation in response to neuronal stress result in functional downregulation.

    J Neurosci. 2007 Feb 14;27(7):1642-50.

  • Wake H.

    KCC2 phosphorylation in injured brain.

    Bulletin of the Japanese Society for Neurochemistry Vol47(No.1) pp31-35 2008

  • Iohara K, Zheng L, Wake H, Ito M, Nabekura J, Wakita H, Nakamura H, Into T, Matsushita K, Nakashima M.

    A novel stem cell source for vasculogenesis in ischemia: subfraction of side population cells from dental pulp.

    Stem Cells. 2008 Sep;26(9):2408-18.

  • Wake H, Moorhouse AJ, Jinno S, Kohsaka S, Nabekura J.

    Resting microglia directly monitor the functional state of synapses in vivo and determine the fate of ischemic terminals.

    J Neurosci. 2009 Apr 1;29(13):3974-80.

  • Watanabe M, Wake H, Moorhouse AJ, Nabekura J.

    Clustering of neuronal K+-Cl-cotransporters in lipid rafts by tyrosine phosphorylation.

    J Biol Chem. 2009 Oct 9;284(41):27980-8.

  • Marumo T, Eto K, Wake H, Omura T, Nabekura J.

    The inhibitor of 20-HETE synthesis, TS-011, improves cerebral microcirculatory autoregulation impaired by middle cerebral artery occlusion in mice.

    Br J Pharmacol. 2010 Nov;161(6):1391-402.

  • Sagisaka T, Matsukawa N, Toyoda T, Uematsu N, Kanamori T, Wake H, Borlongan CV, Ojika K.

    Directed neural lineage differentiation of adult hippocampal progenitor cells via modulation of hippocampal cholinergic neurostimulating peptide precursor expression.

    Brain Res. 2010 Apr 23;1327:107-17.

  • Sawada M, Kaneko N, Inada H, Wake H, Kato Y, Yanagawa Y, Kobayashi K, Nemoto T, Nabekura J, Sawamoto K.

    Sensory input regulates spatial and subtype-specific patterns of neuronal turnover in the adult olfactory bulb.

    J Neurosci. 2011 Aug 10;31(32):11587-96.

  • Eto K, Wake H, Watanabe M, Ishibashi H, Noda M, Yanagawa Y, Nabekura J.

    Inter-regional contribution of enhanced activity of the primary somatosensory cortex to the anterior cingulate cortex accelerates chronic pain behavior.

    J Neurosci. 2011 May 25;31(21):7631-6.

  • Wake H, Lee PR, Fields RD.

    Control of local protein synthesis and initial events in myelination by action potentials.

    Science. 2011 Sep 16;333(6049):1647-51.

  • Tremblay ME, Stevens B, Sierra A, Wake H, Bessis A, Nimmerjahn A.

    The role of microglia in the healthy brain.

    J Neurosci. 2011 Nov 9;31(45):16064-9. Review.

  • Wake H, Moorhouse AJ, Nabekura J.

    Functions of microglia in the central nervous system–beyond the immune response.

    Neuron Glia Biol. 2011 Feb;7(1):47-53. Review.

  • Inada H, Watanabe M, Uchida T, Ishibashi H, Wake H, Nemoto T, Yanagawa Y, Fukuda A, Nabekura J.

    GABA regulates the multidirectional tangential migration of GABAergic interneurons in living neonatal mice.

    PLoS One. 2011;6(12):e27048.

  • Wake H, Fields RD.

    Physiological function of microglia.

    Neuron Glia Biol. Feb;7(1):1-3. 2011

  • Leung JY, Bennett WR, Herbert RP, West AK, Lee PR, Wake H, Fields RD, Chuah MI, Chung RS.

    Metallothionein promotes regenerative axonal sprouting of dorsal root ganglion neurons after physical axotomy.

    Cell Mol Life Sci. 2012 Mar;69(5):809-17.

  • Toyoda T, Matsukawa N, Sagisaka T, Uematsu N, Kanamori T, Kato D, Mizuno M, Wake H, Hida H, Borlongan CV, Ojika K.

    Suppression of astrocyte lineage in adult hippocampal progenitor cells expressing hippocampal cholinergic neurostimulating Peptide precursor in an in vivo ischemic model.

    Cell Transplant. 2012;21(10):2159-69.

  • Wake H, Moorhouse AJ, Miyamoto A, Nabekura J.

    Microglia: actively surveying and shaping neuronal circuit structure and function.

    Trends Neurosci. 2013;36(4):209-17.

  • Miyamoto A, Wake H, Moorhouse AJ, Nabekura J.

    Microglia and synapse interactions: fine tuning neural circuits and candidate molecules.

    Front Cell Neurosci. 2013 May 15;7:70.

  • Fields RD, Araque A, Johansen-Berg H, Lim SS, Lynch G, Nave KA, Nedergaard M, Perez R, Sejnowski T, Wake H.

    Glial biology in learning and cognition.

    Neuroscientist. 2014 Oct;20(5):426-31.

  • Wake H.

    The mechanism for activity dependent regulation of myelin.

    Seikagaku. 2013 Nov;85(11):999-1002. Review. Japanese.

  • Sierra A, Tremblay ME, Wake H.

    Never-resting microglia: physiological roles in the healthy brain and pathological implications.

    Front Cell Neurosci. 2014 Aug 15;8:240.

  • Wake H, Kato D.

    Brain function and white matter.

    Brain Nerve. 2015 Apr;67(4):505-12. Japanese.

  • Wake H, Kato D. Frontiers in Live Bone Imaging Researches.

    In vivo imaging of neuron and glia.

    Clin Calcium. 2015;25(6):859-70. doi: CliCa1506859870. Japanese.

  • Wake H, Ortiz FC, Woo DH, Lee PR, Angulo MC, Fields RD.

    Nonsynaptic junctions on myelinating glia promote preferential myelination of electrically active axons.

    Nat Commun. 2015 Aug 4;6:7844.

  • Kato G, Inada H, Wake H, Akiyoshi R, Miyamoto A, Eto K, Ishikawa T, Moorhouse AJ, Strassman A, Nabekura J.

    Microglial contact prevents excess depolarization and rescues neurons from excitotoxicity.

    eNeuro. 2016. 0004-16.

  • Miyamoto A, Wake H, Ishikawa AW, Eto K, Shibata K, Murakoshi H, Koizumi S, Moorhouse AJ, Yoshimura Y, Nabekura J.

    Microglia contact induces synapse formation in developing somatosensory cortex.

    Nat Commun. 2016. Aug 25;7:12540.

  • Kato D, Eto K, Nabekura J, Wake H.

    Activity-dependent functions of non-electrical glial cells.

    J Biochem. 2018 Jun 1;163(6):457-464.

  • Ishikawa T, Eto K, Kim SK, Wake H, Takeda I, Horiuchi H, Moorhouse AJ, Ishibashi H, Nabekura J.

    Cortical astrocytes prime the induction of spine plasticity and mirror image pain.

    Pain. 2018 Aug;159(8):1592-1606.

  • Akiyoshi R, Wake H, Kato D, Horiuchi H, Ono R, Ikegami A, Haruwaka K, Omori T,Tachibana Y, Moorhouse AJ, Nabekura J.

    Microglia enhance synapse activity to promote local network synchronization.

    eNeuro. 2018 Oct 25;5(5). 0088-18.

  • Takeda A, Shinozaki Y, Kashiwagi K, Ohno N, Eto K, Wake H, Nabekura J, Koizumi S.

    Microglia mediate non-cell-autonomous cell death of retinal ganglion cells.

    Glia. 2018 Oct 29. doi: 10.1002/glia.23475.

  • Dutta DJ, Woo DH, Lee PR, Pajevic S, Bukalo O, Huffman WC, Wake H, Basser PJ, SheikhBahaei S, Lazarevic V, Smith JC, Fields RD.

    Regulation of myelin structure and conduction velocity by perinodal astrocytes.

    Proc Natl Acad Sci U S A. 2018 Oct 29. pii: 201811013.

  • Quan X, Kumar M, Matoba O, Awatsuji Y, Hayasaki Y, Hasegawa S, Wake H.

    Three-dimensional stimulation and imaging-based functional optical microscopy of biological cells.

    Opt Lett. 2018 Nov 1;43(21):5447-5450.

  • Akiyoshi R, Wake H, Kato D, Horiuchi H, Ono R, Ikegami A, Haruwaka K, Omori T, Tachibana Y, Moorhouse AJ, Nabekura J.

    Microglia Enhance Synapse Activity to Promote Local Network Synchronization.

    eNeuro. 2018 Oct 25;5(5).

  • Sołtysik K, Ohsaki Y, Tatematsu T, Cheng J, Fujimoto T.

    Nuclear lipid droplets derive from a lipoprotein precursor and regulate phosphatidylcholine synthesis.

    Nat Commun. 2019 Jan 28;10(1):473.

  • Ikegami A, Haruwaka K, Wake H.

    Microglia: Lifelong modulator of neural circuits.

    Neuropathology. 2019 Jun;39(3):173-180.

  • Wake H, Horiuchi H, Kato D, Moorhouse AJ, Nabekura J.

    Physiological Implications of Microglia-Synapse Interactions.

    Methods Mol Biol. 2019;2034:69-80.

  • Kato D, Ikegami A, Horiuchi H, Moorhouse AJ, Nabekura J, Wake H.

    In Vivo Two-Photon Imaging of Microglial Synapse Contacts.

    Methods Mol Biol. 2019;2034:281-286.

  • Murakami J, Tachibana Y, Akiyama S, Kato T, Taniguchi A, Nakajima Y, Shimoda M, Wake H, Kano Y, Takada M, Nambu A, Yoshida A.

    Oral splint ameliorates tic symptoms in patients with tourette syndrome.

    Mov Disord. 2019 Oct;34(10):1577-1578.

  • Kato D, Wake H, Lee PR, Tachibana Y, Ono R, Sugio S, Tsuji Y, Tanaka YH, Tanaka YR, Masamizu Y, Hira R, Moorhouse AJ, Tamamaki N, Ikenaka K, Matsukawa N, Fields RD, Nabekura J, Matsuzaki M.

    Motor learning requires myelination to reduce asynchrony and spontaneity in neural activity.

    Glia. 2020 Jan;68(1):193-210.

  • Kato D, Wake H.

    Activity-Dependent Myelination.

    Adv Exp Med Biol. 2019;1190:43-51.

  • Shimobayashi SF, Ohsaki Y.

    Universal phase behaviors of intracellular lipid droplets.

    Proc Natl Acad Sci U S A. 2019 Dec 17;116(51).

  • Haruwaka K, Ikegami A, Tachibana Y, Ohno N, Konishi H, Hashimoto A, Matsumoto M, Kato D, Ono R, Kiyama H, Moorhouse AJ, Nabekura J, Wake H.

    Dual microglia effects on blood brain barrier permeability induced by systemic inflammation.

    Nat Commun. 2019 Dec 20;10(1):5816.

  • Tsuji T, Ozasa H, Aoki W, Aburaya S, Yamamoto Funazo T, Furugaki K, Yoshimura Y, Yamazoe M, Ajimizu H, Yasuda Y, Nomizo T, Yoshida H, Sakamori Y, Wake H, Ueda M, Kim YH, Hirai T.

    YAP1 mediates survival of ALK-rearranged lung cancer cells treated with alectinib via pro-apoptotic protein regulation.

    Nat Commun. 2020 Jan 3;11(1):74.

  • Hattori Y, Naito Y, Tsugawa Y, Nonaka S, Wake H, Nagasawa T, Kawaguchi A, Miyata T.
    Transient microglial absence assists postmigratory cortical neurons in proper differentiation.
    Nat Commun. 2020 Apr 2;11(1):1631. 

  • Badimon A, Strasburger HJ, Ayata P, Chen X, Nair A, Ikegami A, Hwang P, Chan AT, Graves SM,  Uweru JO, Ledderose C, Kutlu MG,  Wheeler MA,  Kahan A,  Ishikawa M, Wang Y-C, Loh Y-H E, Jiang JX, Surmeier DJ, Robson SC, Junger WG, Sebra R, Calipari ES,  Kenny PJ, Eyo UB, Colonna M, Quintana FJ, Wake H, Gradinaru V, Schaefer A.

    Negative feedback control of neuronal activity by microglia. 

    Nature 2020 Oct;586(7829)

  • Ozaki K, Kato D, Ikegami A, Hashimoto A, Sugio S, Guo Z, Shibushita M, Tatematsu T, Haruwaka K, Moorhouse AJ, Yamada H, Wake H

    Maternal immune activation induces sustained changes in fetal microglia motility.

    Sci Rep. 2020 Dec 7;10(1):21378

  • Sołtysik K, Ohsaki Y, Tatematsu T1, Cheng J, Maeda A, Morita SY, Fujimoto T

    Nuclear lipid droplets form in the inner nuclear membrane in a seipin-independent manner

    J Cell Biol. 2021 Jan 4;220(1):e202005026. 
  • Okada T, Kato D, Nomura Y, Obata N, Quan X, Morinaga A, Yano H, Guo Z, Aoyama Y, Tachibana Y, Moorhouse AJ, Matoba O, Takiguchi T, Mizobuchi S and Wake H 
    Pain induces stable, active microcircuits in the somatosensory cortex that provide a new therapeutic target
    Science Advances 2021 19 Mar DOI: 10.1126/sciadv.abd8261
  • Kato D, Wake H 
    Myelin plasticity modulates neural circuitry required for learning and behavior
    Neurosci Res. 2021 Jun;167:11-16. doi: 10.1016/j.neures.2020.12.005. Epub 2021 Jan 5.
  • Quan X, Kato D, Daria V, Matoba O, Wake H 
    Holographic microscope and its biological application
    Neurosci Res. 2021 Nov 2;S0168-0102(21)00220-0.     doi: 10.1016/j.neures.2021.10.012.
  • Takeda I, Yoshihara K, Cheung DL, Kobayashi T, Agetsuma M, Tsuda M, Eto K, Koizumi S, Wake H, Moorhouse AJ, Nabekura J

    Controlled activation of cortical astrocytes modulates neuropathic pain-like behaviour

    Nat Commun. 2022 Jul 14;13(1):4100. doi: 10.1038/s41467-022-31773-8.

  • Kato D, Quan X, Tanisumi Y, Guo Z, Morita M, Takiguchi T, Matoba S, Wake H
    Evaluation and Manipulation of Neural Activity using Two-Photon Holographic Microscopy
    J Vis Exp. 2022 Sep 16;(187). doi: 10.3791/64205.

  • Sugio S, Kato D, Wake H
    Myelinated axon as a plastic cable regulating brain functions
    Neurosci Res. 2022 Nov 5;S0168-0102(22)00271-1. doi: 10.1016/j.neures.2022.11.002.

  • Hashimoto A, Kawamura N, Tarusawa E , Takeda I , Aoyama Y, Ohno N, Inoue M, Kagamiuchi M, Kato D, Matsumoto M, Hasegawa Y, Nabekura J, Schaefer A, Moorhouse AJ, Yagi T, and Wake H
    Microglia Enable Cross-Modal Plasticity by Removing Inhibitory Synapses
    Cell Rep. 2023 Apr 21; doi: 10.1016/j.celrep.2023.112383.
    https://www.cell.com/cell-reports/fulltext/S2211-1247(23)00394-7

  • Kato D, Aoyama Y, Nishida K, Takahashi Y, Sakamoto T, Takeda I, Tatematsu T, Go S, Saito Y, Kunishima S, Cheng J, Hou L, Tachibana Y, Sugio S, Kondo R, Eto F, Sato S, Moorhouse AJ, Yao I, Kadomatsu K, Setou M and Wake H

    Regulation of lipid synthesis in myelin modulates neural activity and is required for motor learning 

    Glia 2023 July 3 doi: 10.1002/glia.24441

    https://onlinelibrary.wiley.com/doi/full/10.1002/glia.24441

  • Yoshida K, Kato D, Susio S, Takeda I, Wake H

    Activity-dependent oligodendrocyte calcium dynamics and their changes in Alzheimer’s disease

    Front. Cell. Neurosci., 31 October 2023

    https://doi.org/10.3389/fncel.2023.1154196