▽研究業績

論文(2000年~)

2013

  1. Yamaguchi T, Hosono Y, Yanagisawa K, Takahashi T. NKX2-1/TTF-1: an enigmatic oncogene that functions as a double-edged sword for cancer cell survival and progression. Cancer Cell 23:718-723, 2013.
  2. Kawahara T, Hotta N, Ozawa Y, Kato S, Kano K, Yokoyama Y, Nagino M, Takahashi T, Yanagisawa K. Quantitative proteomic profiling identifies DPYSL3 as pancreatic ductal adenocarcinoma-associated molecule that regulates cell adhesion and migration by stabilization of focal adhesion complex. PLoS ONE 8(12):e79654, 2013.
  3. Attoub S, Sperandio O, Raza H, Arafat K, Al-SaAttoub S, Arafat K, Gelaude A, Sultan MAA, Bracke M, Collin, P, Takahashi T, Adrian, T, De Wever O. Frondoside A suppressive effects on lung cancer survival, tumor growth, angiogenesis, invasion, and metastasis. PLoS ONE 8:e53087, 2013.
  4. Attoub S, Sperandio O, Raza H, Arafat K, Al-Salam S, Al Sultan MA, Al Safi M, Takahashi T, Adem A. Thymoquinone as an anticancer agent: evidence from inhibition of cancer cells viability and invasion in vitro and tumor growth in vivo. Fundam Clin Pharmacol. 27: 557-569, 2013.
  5. Roth FC, Mulder JE, Brien JF, Takahashi T, Massey TE. Cytotoxic interaction between amiodarone and desethylamiodarone in human peripheral lung epithelial cells. Chem Biol Interact. 204:135-139, 2013. DOI: 10.1016/j.cbi.2013.05.006
  6. Arafat K, Iratni R, Takahashi T, Parekh K, Al Dhaheri Y, Adrian TE, Attoub S. Inhibitory effects of salinomycin on cell survival, colony growth, migration, and invasion of human non-small cell lung cancer A549 and LNM35: Involvement of NAG-1. PLoS ONE, 8:e66931, 2013.
  7. Yamashita Y, Akatsuka S, Shinjo K, Yatabe Y, Kobayashi H, Seko H, Kajiyama H, Kikkawa F, Takahashi T, Toyokuni S. Met is the most frequently amplified gene in endometriosis-associated ovarian clear cell adenocarcinoma and correlates with worsened prognosis. PLoS ONE. 8:e57724, 2013.

2012

  1. Yamaguchi T, Yanagisawa K, Sugiyama R, Hosono Y, ShimadaY, Arima C, Kato S, Tomida S, Suzuki M, Osada H, Takahashi T. NKX2-1/TITF1/TTF-1-induced ROR1 is required to sustain EGFR survival signaling in lung adenocarcinoma. Cancer Cell 21: 348-361, 2012.
  2. Hosono Y, Yamaguchi T, Mizutani E, Yanagisawa K, Arima C, Tomida S, Shimada Y, Hiraoka M, Kato S, Yokoi K, Suzuki M, Takahashi T. MYBPH, a transcriptional target of TTF-1, inhibits ROCK1, and reduces cell motility and metastasis. EMBO J 31: 481-493, 2012.
  3. Hosono Y, Usukura J, Yamaguchi T, Yanagisawa K, Suzuki M, Takahashi T. MYBPH inhibits NM IIA assembly via direct interaction with NMHC IIA and reduces cell motility. Biochem Biophys Res Commun 428:173-178, 2012.
  4. Yanagisawa K, Tomida, S, Matsuo K, Arima C, Kusumegi M, Yokoyama Y, Ko SBH., Mizuno N, Kuroyanagi Y, Kwahara T, Takeuchi T, Goto H, Yamao K, Nagino M, Tajima K, Takahashi T. Seven-signal proteomic signature for detection of operable pancreatic cancer and their discrimination from autoimmune pancreatitis. Int. J. Proteomics. 2012 (doi:10.1155/2012/510397).
  5. Suzuki M, Takahashi T. Aberrant DNA replication in cancer. Mutat. Res. 743-44: 111-117, 2012.
  6. Kalari S, Jung M, Kernstine KH, Takahashi T, Pfeifer GP. The DNA methylation landscape of small cell lung cancer suggests a differentiation defect of neuroendocrine cells. Oncogene (in press). doi: 10.1038/onc.2012.362
  7. Cao K, Tanaka K, Komizu Y, Tamiya-Koizumi K, Murate T, Ueoka R, Kyogashima M, Usukura J, Takahashi T, Suzuki M. Hybrid liposomes affect cellular lipid constituents and caveolae structures. Bioorg Med Chem Lett. 22:1731-1733, 2012.
  8. Endo M, Nakano M, Kadomatsu T, Fukuhara S, Kuroda H, Mikami S, Hato T, Aoi J, Horiguchi H, Miyata K, Odagiri H, Masuda T, Harada M, Horio H, Hishima T, Nomori H, Ito T Yamamoto Y, Minami T, Okada S, Takahashi T, Mochizuki N, Iwase H, Oike Y. A critical role for tumor cell-derived angiopoientin-like protein 2 in metastasis. Cancer Res. 72: 1784-1794, 2012.
  9. Akatsuka S, Yamashita Y, Ohara H, Liu Y-T, Izumiya M, Abe K, Ochiai M, Jiang L, Nagai H, Okazaki Y, Murakami H, Sekido Y, Arai E, Kanai Y, Hino O, Takahahi T, Nakagama H, Toyokuni S. Fenton reaction induced cancer in wild type rats recapitulates genomics alterations observed in human cancer. PLoS ONE 7: e43403. doi:10.1371/journal.pone.0043403
  10. Jiang L Akatsuka S, Nagai H, Chew S-H, Ohara H, Okazaki Y, Yamashita Y, Yoshikawa Y, Yasui H, Ikuta K, Sasaki K, Kohgo Y, Hirano S, Shinohara Y, Kohyama N, Takahashi T, Toyokuni S. Iron overload signature in chrysotile-induced malignant mesothelioma. J Pathol. 228: 366-377, 2012.
  11. Kobayashi H, Yamashita Y, Iwase A, Yoshikawa Y, Yasui H, Kwai Y, Uchida K, Uno N, Akatsuka, S, Takahashi T, Kikkawa F, and Toyokuni S. The ferroimmunomodulatory role of ectopic endometriotic stromal cells in ovarian endometriosis. Fertility and Sterility. 98: 415-422, 2012.

2011

  1. Nishikawa E*, Osada H*, Okazaki Y, Arima C, Tomida S, Tatematsu Y, Taguchi A, Shimada Y, Yanagisawa K, Yatabe Y, Toyokuni S, Sekido Y, and Takahashi T. miR-375 is activated by ASH1 and inhibits YAP1 in a lineage-dependent manner in lung cancer. Cancer Res. 71:6165-6173, 2011. (*equal contributors)
  2. Matsuyama, Y., Suzuki, M., Arima, C., Huang, Q.M., Tomida, S., Takeuchi, T., Sugiyama, R., Itoh, Y., Yatabe, Y., Goto, H. and Takahashi, T. Proteasomal non-catalytic subunit PSMD2 as a potential therapeutic target in association with various clinicopathologic features in lung adenocarcinomas. Mol. Carcinog. 50: 301-309, 2011.
  3. Shimamura, T., Imoto, S., Shimada, Y., Hosono, Y., Niida, A., Nagasaki, M., Yamaguchi, R., Takahashi, T., Miyano, S. A novel network profiling analysis reveals system changes in epithelial-mesenchymal transition. PLoS ONE 6: e20804. doi:10.1371/journal.pone.0020804, 2011
  4. Osada, H. and Takahashi, T. let-7 and miR-17-92: Small-sized major players in lung cancer development. Cancer Sci. 102:9-17, 2011. (review)
  5. Sides, M., Klingsberg, R.C., Shan, B., Gordon, K.A., Nguyen, H.T., Lin, Z., Takahashi, T., Flemington, E.K., and Lasky, J.A. The Epstein-Barr virus LMP 1 and TGF-β1 synergistically induce EMT in lung epithelial cells. Am. J. Resp. Cell Mol. Biol. 44:852-862, 2011.
  6. Attoub S, Hassan AH, Vanhoecke B, Iratni R, Takahashi T, Gaben AM, Bracke M, Awad S, Kamalboor JA, Al Sultan MAH, Arafat K, Gespach C and Petroianu G. Inhibition of cell survival, invasion, tumor growth and histone deacetylase activity by the dietary flavonoid luteolin in human epithelioid cancer cells. Eur. J. Pharmacol. 651: 18-25, 2011
  7. Mulder, J.E., Brien, J.F., Racz, W.J., Takahashi, T. and Massey, T. Mechanisms of amiodarone and desethylamiodarone cytotoxicity in non-transformed human peripheral lung epithelial cells. J. Pharmacol. Exp. Ther. 336:551-559, 20011.
  8. Travis WD, Brambilla E, Noguchi M, Nicholson AG, Geisinger KR, Yatabe Y, Beer DG, Powell CA, Eiely GJ, Van Schil PE, Garg, K, Austin JHM, Asamura H, Rusch, VW, Hirsch FR, Scagliotti G, MisudomiT, Huber RM, Ishikawa Y, Jett, J, Sanchez-Cespedes, M, Sculier, JP, Takahashi T, Tsuboi, M, Vansteenkiste J, Wistuba I, Yang, P-C, Aberle D, Brambilla C, Flieder D, Franklin W, Johnson B, Johnson D, Kerr K, Kuriyama K, Lee JS, Miller VA, pertersen I, Roggli V, Rosell R, Saijo N, Thunnissen E, Tsao M, Yankelewitz D. International Association for the Study of Lung Cancer/Amerian Thoracic Society/European Respiratory Society International Multidisciplinary Classification of lung adenocarcinoma. J Thorac. Oncol. 6: 244-285, 2011.

2010

  1. Yanagisawa K, Konishi H, Arima C, Tomida S, Takeuchi T, Shimada Y, Yatabe Y, Mitsudomi T, Osada H, and Takahashi T. Novel metastasis-related gene CIM functions in the regulation of multiple cellular stress response pathways. Cancer Res. 70:9949-58, 2010.
  2. Huang QA, Tomida S, Masuda Y, Arima C, Cao K, Kisahara T, Osada H, Yatabe Y, Kamiya K, Takahashi T and Suzuki M. Regulation of DNA polymerase POLD4 influences genomic instability in lung cancer. Cancer Res. 70:8407-8416, 2010.
  3. Tanaka S, Cao K, Niimi A, Limsirichaikul S, Huang Q, Nakamura N, Murate T, Hasegawa Y, Takahashi T and Suzuki M. Functions of base selection step in human DNA polymerase alpha. DNA Repair 9:534-541, 2010.
  4. Huang QA, Akashi T, Matsuda Y, Kamiya K, Takahashi T. and Suzuki M. Roles of POLD4, smallest subunit of DNA polymerase δ, in nuclear structures and genomic stability of human cells. Biochem. Biophys. Res. Comm. 391:542-546, 2010.
  5. Miki D, Kubo M, Takahashi A, Yoon K-A, Kim J, Lee GK, Zo JI, Lee JS, Hosono N, Morizono T, Tsunoda T, Kamatani N, Chayama K, Takahashi T, Inazawa J, Nakamura Y and Daigo Y. Variation in TP63 is associated with lung adenocarcinoma susceptibility in Japanese and Korean populations. Nature Genet. 42:893-896, 2010.
  6. Hu Q, Akatsuka S, Yamashita Y, Ohara H, Nagai H, Okazaki Y, Takahashi T, and Toyokuni S. Homozygous deletion of CDKN2A/2B is a hallmark of iron-induced high-grade rat mesothelioma. Lab. Invest. 90:360-373, 2010.
  7. Bryant CM, Albertus DL, Kim S, Guedj M, Travis WD, Yatabe Y, Takahashi T, Brambilla E, and Beer DG. Clinically relevant characterization of lung adenocarcinoma subtypes based on cellular pathways. PLoS One 5: e11712, 2010. doi:10.1371/journal.pone.0011712.
  8. Heishi T, Hosaka T, Suzuki H, Suzuki Y, Miyashita H, Oike Y, Takahashi T, Nakamura T, Arioka S, Mitsuda Y, Takakura T, Hojo K, Matsumoto M, Yamauchi C, Ohta H, Sonoda H and Sato Y. Endogenous angiogenesis inhibitor vasohibin1 exhibits a broad-spectrum anti-lymphangiogenic activity and suppresses lymph node metastasis. Am. J. Pathol. 176:1950-1958, 2010. 
  9. Sadej R, Romanska H, Kavanagh D, Baldwin G, Takahashi T, Kalia N, Berditchevski F. Tetraspanin CD151 regulates TGF-β signalling: implication in tumour metastasis. Cancer Res. 70:6059–6070, 2010.
  10. Alifano M, Souazé F, Dupouy S, Camilleri-Broët S, Takahashi T, Ahmed-Zaïd S, Cancellieri A, Damiani S, Boaron M, Broët P, Miller LD, Gespach G, Regnard JF and Forgez P. Neurotensin receptor 1 determines the outcome of non-small cell lung cancer. Clin. Cancer Res. 16: 4401-4410, 2010.
  11. Murakami M, Ito H, Hagiwara K, Yoshida K, Sobue S, Ichihara M, Takagi A, Kojima T, Tanaka K, Tamiya-Koizumi K, Kyogashima M, Suzuki M, Banno Y, Nozawa Y, Murate T: ATRA inhibits ceramide kinase transcription in a human neuroblastoma cell line, SH-SY5Y cells: the role of COUP-TFI. J Neurochem 112: 511-520, 2010.

2009

  1. Tomida S, Takeuchi T, Shimada Y, Arima C, Matsuo K, Mitsudomi T, Yatabe Y, Takahashi T: Relapse-related molecular signature in lung adenocarcinomas identifies patients with dismal prognosis. J Clin Oncol 27:2793-2799, 2009.
  2. Ebi H*, Tomida S,* Takeuchi T, Arima C, Sato T, Mitsudomi T, Yatabe Y, Osada H, Takahashi T: Relationship of deregulated signaling converging onto mTOR with prognosis and classification of lung adenocarcinoma shown by two independent in silico analyses. Cancer Res. 69: 4027-2035, 2009 (*equal contributors).
  3. Ebi H*, Sato T*, Sugito N, Hosono Y, Suzuki M, Yamaguchi T, Yatabe Y, Osada H, Takahashi T: Counterbalancing influence of miR-17-92 overexpression on adverse effects of RB inactivation in lung cancers. Oncogene 28:3371-3379, 2009. (*equal contributors)
  4. Suzuki M, Niimi A, Limsirichaikul S, Tomida S, Huang Q M, Izuta S, Usukura J, Itoh Y, Hishida T, Akashi T, Nakagawa Y, Kikuchi A, Pavlov Y, Murate T, Takahashi T: PCNA Mono-ubiquitination and Activation of Translesion DNA Polymerases by DNA Polymerase α. J Biochem 146: 13-21, 2009.
  5. Yazawa T, Sato H, Shimoyamada H, Okudela K, Woo H, Tajiri M, Ogura T, Ogawa N, Suzuki T, Mitsui H, Ishii J, Miyata C, Sakaeda M, Goto K, Kashiwagi K, Masuda M, Takahashi T, Kitamura H: Neuroendocrine cancer-specific up-regulating mechanism of insulin-like growth factor binding protein-2 in small cell lung cancer. Am J Pathol 175: 976-987, 2009.
  6. Okudera K, Yazawa T, Woo T, Sakaeda M, Ishii J, Mitsui H, Tajiri M, Ogawa N, Masuda M, Takahashi T, Sugimura H, Kitamura H: Down-regulation of DUSP6 expression in lung cancers: its mechanism and potential role in carcinogenesis. Am J Pathol 175:867–881, 2009.
  7. Otsuka S, Hanibuchi M, Ikuta K, Yano S, Goto H, Ogino H, Yamada T, Kakiuchi S, Nishioka Y, Takahashi T, Sone S: A bone metastasis model with osteolytic and osteoblastic properties of human lung cancer ACC-LC-319/bone 2 in natural killer cell-depleted severe combined immunodeficient mice. Oncol Res 17:581-591, 2009.
  8. Furuhata A, Kimura A, Shide K, Shimoda K, Murakami M, Ito H, Gao S, Yoshida K, Tagawa Y, Hagiwara K, Takagi A, Kojima T, Suzuki M, Abe A, Naoe T, Murate T: p27 deregulation by Skp2 overexpression induced by the JAK2V617 mutation. Biochem Biophys Res Commun 383: 411-416, 2009.
  9. Furuhata A, Murakami M, Ito H, Gao S, Yoshida K, Sobue S, Kikuchi R, Iwasaki T, Takagi A, Kojima T, Suzuki M, Abe A, Naoe T, Murate T: GATA-1 and GATA-2 binding to 3' enhancer of WT1 gene is essential for its transcription in acute leukemia and solid tumor cell lines. Leukemia 23: 1270-1277, 2009.
  10. Gao S, Murakami M, Ito H, Yoshida K, Tagawa Y, Hagiwara K, Takagi A, Kojima T, Suzuki M, Banno Y, Nozawa Y, Murate T: Mechanism of increased PLD1 gene expression during early adipocyte differentiation process of mouse cell line, 3T3-L1. J Cell Biochem 9:375-382, 2009.
  11. Gao S, Murakami S, Ito S, Furuhata A, Yoshida K, Tagawa Y, Hagiwara K, Takagi A, Kojima T, Suzuki M, Banno Y, Nozawa K, Murate T: Mutated Ras induced PLD1 gene expression in human colon cancer cell lines and a mouse cell line of NIH3T3. Nagoya J Med Sci 71: 127-136, 2009.
  12. Ito H, Murakami M, Furuhata A, Gao S, Yoshida K, Sobue S, Hagiwara K, Takagi A, Kojima T, Suzuki M, Banno Y, Tanaka K, Tamiya-Koizumi K, Kyogashima M, Nozawa Y, Murate T: Transcriptional regulation of neutral sphingomyelinase 2 gene expression of a human breast cancer cell line, MCF-7, induced by the anti-cancer drug, daunorubicin. Biochim Biophys Acta 1789: 681-690, 2009.

2008

  1. Taguchi A, Yanagisawa K, Tanaka M, Cao K, Matsuyama Y, Goto H, Takahashi T: Identification of HIF-1α as a novel target for miR-17-92 microRNA cluster. Cancer Res 68: 5540-5545, 2008.
  2. Osada H, Tomida S, Yatabe Y, Tatematsu Y, Takeuchi T, Murakami H, Kondo Y, Sekido Y, Takahashi T: Roles of ASH1 in DKK1 and E-cadherin repression and neuroendocrine differentiation in lung cancer. Cancer Res 68:1647-1655, 2008.
  3. Tokumaru S, Suzuki M, Yamada H, Nagino N, Takahashi T: let-7 regulates Dicer expression and constitutes a negative feedback loop. Carcinogenesis 29: 2073-2077, 2008.
  4. Yamada H, Yanagisawa K, Tokumaru S, Taguchi A, Nimura Y, Osada H, Nagino M, Takahashi T: Detailed characterization of a homozygously deleted region corresponding to a candidate tumor suppressor locus at 21q11-21 in human lung cancer. Genes Chromosomes Cancer 47: 810-818, 2008.
  5. Yatabe Y, Takahashi T, Mitsudomi T: Epidermal growth factor receptor gene amplification is acquired in association with tumor progression of EGFR-mutated lung cancer. Cancer Res 68: 2106-2111, 2008.
  6. Shimizu J, Horio Y, Osada H, Hida T, Hasegawa Y, Shimokata K, Takahashi T, Sekido Y, Yatabe Y: mRNA expression of RRM1, ERCC1 and ERCC2 is not associated with chemosensitivity to cisplatin, carboplatin and gemcitabine in human lung cancer cell lines. Respirology 13: 510-517, 2008.
  7. Arima C, Hakamada K, Okamoto M, Hanai T: Modified Fuzzy Gap Statistic for Estimating Preferable Number of Clusters in Fuzzy k-Means Clustering. J Biosci Bioeng 105:273-281, 2008.
  8. Iwasaki T, Murakami M, Sugisaki C, Sobue S, Ohashi H, Asano H, Suzuki M, Nakamura S, Ito M, Murate T: Characterization of myelodysplastic syndrome and aplastic anemia by immunostaining of p53 and hemoglobin F and karyotype analysis: differential diagnosis between refractory anemia and aplastic anemia. Pathol Int 58: 353-360, 2008.
  9. Sobue S, Murakami M, Banno Y, Ito H, Kimura A, Gao S, Furuhata A, Takagi A, Kojima T, Suzuki M, Nozawa Y, Murate T: v-Src oncogene product increases sphingosine kinase 1 expression through mRNA stabilization: alteration of AU-rich element-binding proteins. Oncogene 27: 6023-6033, 2008.
  10. Sobue S, Nemoto S, Murakami M, Ito H, Kimura A, Gao S, Furuhata A, Takagi A, Kojima T, Nakamura M, Ito Y, Suzuki M, Banno Y, Nozawa Y, Murate T: Implications of sphingosine kinase 1 expression level for the cellular sphingolipid rheostat: relevance as a marker for daunorubicin sensitivity of leukemia cells. Int J Hematol 87: 266-275, 2008.
  11. Takemura M, Sugimura K, Okumura K, Limsirichaikul S, Suzuki M, Yamada Y, Yoshida S: Hyper-phosphorylated retinoblastoma protein suppresses telomere elongation. Biosci Biotechnol Biochem 72: 630-635, 2008.

2007

  1. Tomida S*, Yanagisawa K*, Koshikawa K, Yatabe Y, Mitsudomi T, Osada H, Takahashi T: Identification of a metastasis signature and the DLX4 homeobox protein as a regulator of metastasis by combined transcriptome approach. Oncogene 26: 4600-4608, 2007. (*equal contributors)
  2. Yanagisawa K*, Tomida S*, Shimada Y, Yatabe Y, Mitsudomi T, Takahashi T: A 25-signal proteomic signature and outcome for patients with resected non-small-cell lung cancer. J Natl Cancer Inst 99: 858-867, 2007. (*equal contributors)
  3. Tanaka H*, Yanagisawa K*, Shinjo K, Taguchi A, Maeno K, Tomida S, Shimada Y, Osada H, Kosaka T, Matsubara H, Mitsudomi T, Sekido Y, Tanimoto M, Yatabe Y, Takahashi T. Lineage-specific dependency of lung adenocarcinomas on the lung development regulator TTF-1. Cancer Res. 67: 6007-6011, 2007. (*equal contributors)
  4. Ebi H, Matsuo K, Sugito N, Suzuki M, Osada H, Tajima K, Ueda R, Takahashi T: Novel NBS1 heterozygous germline mutation causing MRE11-binding domain loss predisposes to common types of cancer. Cancer Res 67: 11158-11165, 2007.
  5. Nagai H, Sugito N, Matsubara H, Tatematsu Y, Hida T, Sekido Y, Nagino M, Nimura Y, Takahashi T, Osada H: CLCP1 interacts with semaphorin 4B and regulates motility of lung cancer cells. Oncogene 26: 4025-4031, 2007.
  6. Matsubara H*, Takeuchi T*, Nishikawa E*, Yanagisawa K, Hayashita Y, Ebi H, Yamada H, Suzuki M, Nagino M, Nimura Y, Osada H, Takahashi T: Apoptosis induction by antisense oligonucleotides against miR-17-5p and miR-20a in lung cancers overexpressing miR-17-92. Oncogene 26:6099-6105, 2007.
  7. Nicolescu A C, Comeau J L, Hill B C, Bedara L L, Takahashi T, Brien J F, Racz W J, Massey T E: Aryl radical involvement in amiodarone-induced pulmonary toxicity: Investigation of cytoprotection by spin trapping nitorones. Toxicol Appl Pharmacol 220: 60-71, 2007.
  8. Yamashita D, Sano Y, Adachi Y, Okamoto Y, Osada H, Takahashi T, Yamaguchi T, Osumi T, Hirose F: hDREF regulates cell proliferation and expression of ribosomal protein genes. Mol Cell Biol 27: 2003-2013, 2007.
  9. Ranganathan P, Agrawal A, Bhushan R, Chavalmane A K, Kalathur R K R, Takahashi T, Kondaiah P: Expression profiling of genes regulated by TGF-beta: Differential regulation in normal and tumour cells. BMC Genomics 8: 98, 2007.
  10. Sadeghi M M, Esmailzadeh L, Zhang J, Guo X, Asadi A, Krassilnikova S, RastegarFassaei H, Luo G, Al-Lamki R S M, Takahashi T, Tellides G, Bender J R, Rodriguez E R: ESDN is a marker of vascular remodeling and regulator of cell proliferation in graft arteriosclerosis. Am J Transplant 7: 2098-2105, 2007.
  11. Majidi M, Al-Wadei H A, Takahashi T, Schuller H M: Non-genomic β estrogen receptors enhance β1 adrenergic signaling induced by the nicotine-derived carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in human small airway epithelial cells. Cancer Res 67: 6863-6871, 2007.
  12. Sakamoto H, Shimizu J, Horio Y, Ueda R, Takahashi T, Mitsudomi T, Yatabe Y: Disproportionate representation of KRAS gene mutation in atypical adenomatous hyperplasia, but even distribution of EGFR gene mutation from preinvasive to invasive adenocarcinomas. J Pathol 212: 287-294, 2007.
  13. Onozato R, Kosaka T, Achiwa H, Kuwano H, Takahashi T, Yatabe Y Mitsudomi T. LKB1 gene mutations in Japanese lung cancer patients. Cancer Sci 98: 1747-1751, 2007.
  14. Kikuchi R, Murakami M, Sobue S, Iwasaki T, Hagiwara K, Takagi A, Kojima T, Asano H, Suzuki M, Banno Y, Nozawa Y, Murate T: Ewing's sarcoma fusion protein, EWS/Fli-1 and Fli-1 protein induce PLD2 but not PLD1 gene expression by binding to an ETS domain of 5' promoter. Oncogene 26: 1802-1810, 2007.
  15. Kikuchi R, Sobue S, Murakami M, Ito H, Kimura A, Iwasaki T, Shibayama S, Takagi A, Kojima T, Suzuki M, Banno Y, Nozawa Y, Murate T: Mechanism of vitamin D3-induced transcription of phospholipase D1 in HaCat human keratinocytes. FEBS Lett 581: 1800-1804, 2007.
  16. Murakami M, Ichihara M, Sobue S, Kikuchi R, Ito H, Kimura A, Iwasaki T, Takagi A, Kojima T, Takahashi M, Suzuki M, Banno Y, Nozawa Y, Murate T: RET signaling-induced SPHK1 gene expression plays a role in both GDNF-induced differentiation and MEN2-type oncogenesis. J Neurochem 102: 1585-1594 2007
  17. Ram K S, Inagaki M, Yamaguchi T, Thomas B S, Harish C P: Role of Phosphorylation on the Structural Dynamics and Function of Types III and IV Intermediate Filaments. Exp Cell Res 313: 2098-2109, 2007

2006

  1. Takeuchi T*, Tomida S*, Yatabe Y, Kosaka T, Osada H, Yanagisawa K, Mitsudomi T, Takahashi T: Expression profile-defined classification of lung adenocarcinoma shows close relationship with underlying major genetic changes and clinicopathologic behaviors. J Clin Oncol 24: 1679-1688, 2006. (*equal contributors)
  2. Maeno K, Masuda A, Yanagisawa K, Konishi H, Osada H, Saito T, Ueda R, Takahashi T: Altered regulation of c-jun and its involvement in anchorage-independent growth of human lung cancers. Oncogene 25: 271-277, 2006.
  3. Yatabe Y, Hida T, Horio Y, Kosaka T, Takahashi T, Mitsudomi T: A rapid, sensitive assay to detect EGFR mutation in small biopsy specimens from lung cancer. J Mol Diagn 8: 335-341, 2006.
  4. Al-Wadei H A, Takahashi T, Schuller H M: Caffeine stimulates the proliferation of human lung adenocarcinoma cells and small airway epithelial cells via activation of PKA, CREB and ERK1/2. Oncol Rep15: 431-435, 2006.
  5. Ko K, Furukawa K, Takahashi T, Urano T, Sanai Y, Nagino M, Nimura Y, Furukawa K: Fundamental study of small interfering RNAs for ganglioside GD3 synthase gene as a therapeutic target of lung cancers. Oncogene 25: 6924-6935, 2006.
  6. Sato H, Yazawa T, Suzuki T, Shimoyamada H, Okudela K, Ikeda M, Hamada K, Yamada-Okabe H, Yao M, Kubota Y, Takahashi T, Kamma H, Kitamura H. Growth regulation via insulin-like growth factor binding protein-4 and -2 in association with mutant K-ras in lung epithelia. Am J Pathol 169: 1550-1566, 2006.
  7. Pavlov YI, Frahm C, Nick McElhinny S A, Niimi A, Suzuki M, Kunkel T A: Evidence that errors made by DNA polymerase alpha are corrected by DNA polymerase delta. Curr Biol 16: 202-207, 2006.
  8. Sobue S, Iwasaki T, Sugisaki C, Nagata K, Kikuchi R, Murakami M, Takagi A, Kojima T, Banno Y, Akao Y, Nozawa Y, Kannagi R, Suzuki M, Abe A, Naoe T, Murate T: Quantitative RT-PCR analysis of sphingolipid metabolic enzymes in acute leukemia and myelodysplastic syndromes. Leukemia 20: 2042-2046, 2006.
  9. Nishimura T, Yamaguchi T, Tokunaga A, Hara A, Hamaguchi T, Kato K, Iwamatsu A, Okano H, Kaibuchi K: Role of Numb in Dendritic Spine Development with a Cdc42 GEF Intersectin and EphB2. Mol Biol Cell 17: 1273-1285, 2006
  10. Oguri T, Inoko A, Shima H, Izawa I, Arimura N, Yamaguchi T, Inagaki N, Kaibuchi K, Kikuchi K, Inagaki M: Vimentin-Ser82 as a memory phosphorylation site in astrocytes. Genes to Cells 11: 531-540 2006

2005

  1. Hayashita Y, Osada H, Tatematsu Y, Yamada H, Yanagisawa K, Tomida S, Kawahara K, Sekido Y, Takahashi T: A polycistronic miRNA cluster, miR-17-92, is overexpressed in human lung cancers and enhances cell proliferation. Cancer Res 65: 9628-9632, 2005. (*equal contributors)
  2. Osada H, Tatematsu Y, Yatabe Y, Horio Y, Takahashi T: The ASH1 gene is a specific therapeutic target for lung cancers with neuroendocrine features. Cancer Res. 65: 10680-10685, 2005.
  3. Karube Y, Tanaka H, Osada H, Tomida S, Tatematsu Y, Yanagisawa K, Yatabe Y, Takamizawa J, Miyoshi S, Mitsudomi T, Takahashi T: Reduced expression of Dicer associated with poor prognosis in lung cancer patients. Cancer Sci 96: 111-115, 2005.
  4. Osada H, Tatematsu Y, Sugito N, Horio Y, Takahashi T: Histone modification in the TGFβRII gene promoter and its significance for responsiveness to HDAC inhibitor in lung cancer cell lines. Mol Carcinog 44: 233-241, 2005.
  5. Mitsudomi T, Kosaka T, Endoh H, Horio Y, Hida T, Mori S, Hatooka S, Shinoda M, Takahashi T, Yatabe Y: Mutations of the epidermal growth factor receptor gene predict prolonged survival after gefitinib treatment in patients with non-small cell lung cancer with postoperative recurrence. J Clin Oncol 23: 2513-2520, 2005.
  6. Yatabe Y, Kosaka T, Takahashi T, Mitsudomi T: EGFR mutation is specific for terminal respiratory unit type adenocarcinoma. Am J Surg Pathol 29: 633-639, 2005.
  7. He Y, Rajantie I, Pajusola K, Jeltsch M, Holopainen T, Yla-Herttuala S, Harding T, Jooss K, Takahashi T, Alitalo K: Vascular endothelial cell growth factor receptor 3-mediated activation of lymphatic endothelium is crucial for tumor cell entry and spread via lymphatic vessels. Cancer Res 65: 4739-4746, 2005.
  8. Anumanthan G, Halder S K, Osada H, Takahashi T, Massion P P, Carbone D P, Datta P K: Restoration of TGF-β signaling reduces tumorigenecity in human lung cancer cells. Br J Cancer 93: 1157-1167, 2005.
  9. Hussein A, Al-Wadei N, Takahashi T, Shuller H: Theophylline stimulates cAMP-mediated signaling associated with growth regulation in human cells from pulmonary adenocarcinoma and small airway epithelia. Int J Oncol 27: 155-160, 2005.
  10. Al-Wadei H A, Takahashi T, Schuller H M: Growth stimulation of human pulmonary adenocarcinoma cells and small airway epithelial cells by β−carotene via activation of cAMP, PKA, CREB and ERK1/2. Int J Cancer 118:1370-1380, 2005.
  11. Sobue S, Hagiwara K, Banno Y, Tamiya-Koizumi K, Suzuki M, Takagi A, Kojima T, Asano H, Nozawa Y, Murate T: Transcription factor specificity protein 1 (Sp1) is the main regulator of nerve growth factor-induced sphingosine kinase 1 gene expression of the rat pheochromocytoma cell line, PC12. J Neurochem, 95: 940-949, 2005.
  12. Yamaguchi T, Goto H, Yokoyama T, Silljé H, Hanisch A, Uldschmid A, Takai Y, Oguri T, Nigg E A, Inagaki M: Phosphorylation by Cdk1 induces Plk1-mediated vimentin phosphorylation during mitosis. J Cell Biol 171: 431-436, 2005
  13. Nishimura T, Yamaguchi T, Kato K, Yoshizawa M, Nabeshima Y, Ohno S, Hoshino M, Kaibuchi K: PAR-6-PAR-3 mediates Cdc42-induced Rac activation through the Rac GEFs STEF/Tiam1. Nat Cell Biol 7: 270-277, 2005

2004

  1. Nakagawa T, Hayashita Y, Maeno K, Masuda A, Sugito N, Osada H, Yanagisawa K, Ebi H, Shimokata K, Takahashi T: Identification of decatenation G2 checkpoint impairment independently of DNA damage G2 checkpoint in human lung cancer cell lines. Cancer Res 2004; 64: 4826-4832.
  2. Takamizawa J, Konishi H, Yanagisawa K, Tomida S, Osada T, Harano T, Yatabe Y, Nagino M, Nimura Y, Mitsudomi T, Takahashi T: Reduced expression of the let-7 microRNAs in human lung cancers in association with shortened postoperative survival. Cancer Res 2004; 64: 3753-3760
  3. Tomida S, Koshikawa K, Yatabe Y, Harano T, Ogura N, Mitsudomi T, Some M, Takahashi T, Osada H, Takahashi T: Gene expression-based, individualized outcome prediction of surgically treated lung cancer patients. Oncogene 2004, 23: 5360-5370.
  4. Yatabe Y, Mitsudomi T, Takahashi T: Cellular property-associated expression of maspin controlled by promoter DNA methylation in normal lung and non-small cell lung cancers. Oncogene 2004; 23: 4041-4049.
  5. Niimi A, Limsirichaikul S, Yoshida S, Iwai S, Masutani C, Hanaoka F, Kool E T, Nishiyama Y, Suzuki M: Palm mutants in DNA polymerases alpha and eta alter DNAreplication fidelity and translesion activity. Mol Cell Biol 2004; 24: 2734-2746.
  6. Osada H, Tatematsu Y, Saito H, Yatabe Y, Mitsudomi T, Takahashi T: Reduced expression of class II HDAC genes are associated with poor prognosis in lung cancer patients. Int J Cancer 2004; 112:26-32.
  7. Suda N, Ito Y, Imai T, Kikumori T, Kikuchi A, Nishiyama Y, Yoshida S, Suzuki M: The alpha4 residues of human DNA topoisomerase IIalpha function in enzymatic activity and anticancer drug sensitivity: Nucleic Acids Res 2004; 32(5): 1767-1773.
  8. Yatabe Y, Koga T, Mitsudomi T, Takahashi T: A subset of lung adenocarcinoma with CK20 and CDX20 expression, K-ras mutation and goblet cell morphology. J Pathol 2004; 203: 645-652.
  9. Kosaka T, Yatabe Y, Endoh H, Takahashi T, Mitsudomi T: Mutations of the epidermal growth factor receptor gene in lung cancer: biological and clinical implications. Cancer Res (in press).
  10. Endoh H, Tomida S, Yatabe Y, Konishi H, Osada H, Tajima K, Kuwano H, Takahashi T, Mitsudomi T: Prognostic model of pulmonary adenocarcinoma by expression profiling of eight genes as determined by quantitative real-time RT-PCR. J Clin Oncol 2004; 22: 811-819.
  11. Okudera K, Hayashi H, Ito T, Yazawa T, Suzuki T, Nakane Y, Sato H, Ishi H, Keqin X Masuda A, Takahashi T, Kitamura H: K-ras gene mutation enhances motility of immortalized airway cells and lung adenocarcinoma cells via Akt activation (possible contribution to non-invasive expansion of lung adenocarcinoma). Am J Pathol 2004; 164: 91-100.
  12. Hashimoto M, Ichihara M, Watanabe T, Kawai K, Koshikawa K, Yuasa N, Takahashi T, Yatabe Y, Murakumo Y, Zhang J M, Nimura Y, Takahashi M: Expression of CD109 in human cancer. Oncogene 2004; 23: 3716-3720.
  13. Iwafuchi H, Mori N, Takahashi T, Yatabe Y: Phenotypic composition of salivary gland tumors; an application of principle component analysis to tissue microarray data. Modern Pathol 2004; 17: 203-210.
  14. Koga T, Horio Y, Mitsudomi T, Takahashi T, Yatabe Y: A novel approach to identifying markers of tissue-specific expression: Use of MGB in the differential diagnosis of lung tumors in patients with a history of breast cancer. J Mol Diag 2004; 6: 90-95.

2003

  1. Konishi H, Sugiyama M, Mizuno K, Saito H, Yatabe Y, Takahashi T, Osada H. Takahashi T. Detailed characterization of a homozygously deleted region corresponding to a candidate tumor suppressor locus at distal 17p13.3 in human lung cancer. Oncogene 2003; 22: 1892-1905.
  2. Masuda A, Maeno K, Nakagawa T, Saito T, Takahashi T: Association between mitotic spindle checkpoint impairment and susceptibility to the induction of apoptosis by antimicrotubule agents in human lung cancers. Am J Pathol 2003; 163: 1106-1119.
  3. Ogawa M, Limsirichaikul S, Niimi A, Iwai S, Yoshida S, Suzuki M: Distinct function of conserved amino acids in the fingers of Saccharomyces cerevisiae DNA polymerase alpha. J Biol Chem 2003; 278: 19071-19078.
  4. Furuta M, Nozawa K, Takemura M, Izuta S, Murate T, Tsuchiya M, Yoshida K, Taka N, Nimura Y, Yoshida S: A novel platinum compound inhibits telomerase activity in vitro and reduces telomere length in a human hepatoma cell line. Int J Cancer 2003; 104:709-715.
  5. Suda N, Nakagawa Y, Kikuchi A, Sawada M, Takami Y, Fuhanashi H, Nakao A, Yoshida S, Suzuki M: Function of the loop residue Thr792 in human DNA topoisomerase IIalpha. Biochem Biophys Res Commun 2003; 303: 46-51.
  6. Limsirichaikul S, Ogawa M, Niimi A, Iwai S, Murate T, Yoshida S, Suzuki M: The Gly952 residue of Saccharomyces cerevisiae DNA polymerase alpha is important in discriminating correct deoxyribonucleotides from incorrect ones. J Biol Chem 2003; 278: 19079-19086.
  7. Yokoi S, Yasui K, lizasa T, Takahashi T, Fujisawa T, Inazawa J. Downregulation of SKP2 induces apoptosis in lung cancer cells. Cancer Sci 2003; 94: 344-349.
  8. Endoh H, Yatabe Y, Shimizu S, Tajima K, Kuwano H, Takahashi T, Mitsudomi T: RASSF1 gene inactivation in non-small cell lung cancer and its clinical implication. Int J Cancer 2003; 106: 45-51.
  9. Tajima K, Obata Y, Tamaki H, Yshida M, Chen Y -T, Scanloan M J, Old L J, Kuwano H, Takahashi T, Takahashi T, Mitsudomi T: Expression of cancer/testis (CT) antigens in lung cancer. Lung Cancer 2003; 42: 23-33.
  10. Suzuki T, Nakagawa T, Endo H, Mitsudomi T, Masuda A, Yatabe Y, Sugiura T, Takahashi, T, Hida T: The sensitivity of lung cancer cell lines to the EGFR-selective tyrosine kinase inhibitor ZD1839 (‘Iressa’) is not related to the expression of EGFR or HER-2 or to K-ras gene status. Lung Cancer 2003; 42: 35-41.
  11. Hanai T, Yatabe Y, Nakayama Y, Takahashi T, Honda H, Mitsudomi T, Kobayashi T: Prognostic models in patients with non-small-cell lung cancer using artificial neural networks in comparison with logistic regression. Cancer Sci 2003; 94: 473-477.
  12. Cheng R Y S, Zhao A, Alvord W G, Powell D A, Bare R M, Masuda A, Takahashi T, Anderson L M, Kasprzak K S: Gene expression dose-response changes in microarrays after exposure of human peripheral lung epithelial cells to nickel(II). Toxicol Appl Pharm 2003; 191:22-39.
  13. Kurumiya Y, Nagino M, Nozawa K, Kamiya J, Uesaka K, Sano T, Yoshida S, Nimura Y: Biliary bile acid concentration is a simple and reliable indicator for liver function after hepatobiliary resection for biliary cancer. Surgery 2003: 133; 512-520.
  14. Virmani A, Rathi A, Sugio K, Sathyanarayana U G, Toyooka S, Kischel F C, Tonk V, Padar A, Takahashi T, Roth J A, Euhus D M, Minna J D, Gazdar A: Aberrant methylation of TMS1 in small cell, non-small cell lung cancer and breast cancer. Int J Cancer 2003; 106: 198-204.
  15. Sithananda G, Smith G T, Masuda A, Takahashi T, Anderson L M, Fornwald L W: Cell cycle activation in lung adenocarcinoma cells by the ErbB3/phospatidylinositol3 kinase/Akt pathway. Carcinogenesis 2003; 24: 1581-1592
  16. Virmani A, Rathi A, Sugio K, Heda S, Lewis C, Tonk V, Takahashi T, Roth J A, Minna J D, Euhus D M, Gazdar A F: Aberrant methylation of the cyclin D2 promoter in primary small cell, non-small cell and breast cancers. Int J Cancer 2003; 107: 341-345.
  17. Murakami C, Yamazaki T, Hanashima S, Takahashi S, Takemura M, Yoshida S, Ohta K, Yoshida H, Sugawara F, Sakaguchi K, Mizushina Y: A novel DNA polymerase inhibitor and a potent apoptosis inducer: 2-mono-O-acyl-3-O-(alpha-D-sulfoquinovosyl)-glyceride with one stearic acid (alpha-SQMG-C18). Biochim Biophys Acta 2003; 1645:72-80.
  18. Mizushina Y, Xu X, Asahara H, Takeuchi R, Oshige M, Shimazaki N, Takemura M, Yamaguchi T, Kuroda K, Linn S, Yoshida H, Koiwai O, Saneyoshi M, Sugawara F, Sakaguchi K: A sulfoquinovosyl diacylglycerol is a DNA polymerase epsilon inhibitor. Biochem J 2003; 370:299-305.
  19. Mizushina Y, Ishidoh T, Kamisuki S, Nakazawa S, Takemura M, Sugawara F, Yoshida H, Sakaguchi K: Flavonoid glycoside: a new inhibitor of eukaryotic DNA polymerase alpha and a new carrier for inhibitor-affinity chromatography. Biochem Biophys Res Commun 2003; 301:480-487.
  20. Mizushina Y, Murakami C, Yogi K, Ueda K, Ishidoh T, Takemura M, Perpelescu M, Suzuki M, Oshige M, Yamaguchi T, Saneyoshi M, Yoshida H, Sakaguchi K: Kohamaic acid A, a novel sesterterpenic acid, inhibits activities of DNA polymerases from deuterostomes. Biochim Biophys Acta 2003; 1468 55-61, 2003
  21. Mizushina Y, Xu X, Asano N, Kasai N, Kato A, Takemura M, Asahara H, Linn S, Sugawara F, Yoshida H, Sakaguchi K: The inhibitory action of pyrrolidine alkaloid, 1,4-dideoxy-1,4-imino-D-ribitol, on eukaryotic DNA polymerases. Biochem Biophys Res Commun 2003; 304: 78-85.
  22. Mizushina Y, Maeda N, Kawasaki M, Ichikawa H, Murakami C, Takemura M, Xu XN, Sugawara F, Fukumori Y, Yoshida H, Sakaguchi K: Inhibitory action of emulsified sulfoquinovosyl acylglycerol on mammalian DNA polymerases.Lipids. 2003; 38 (10): 1065-1074
  23. Mizushina Y, Hirota M, Murakami C, Ishidoh T, Kamisuki S, Shimazaki N, Takemura M, Perpelescu M, Suzuki M, Yoshida H, Sugawara F, Koiwai O, Sakaguchi K: Some anti-chronic inflammatory compounds are DNA polymerase lambda-specific inhibitors Biochem Pharmacol 2003; 66 (10): 1935-1944.
  24. Murakami C, Takemura M, Yoshida H, Sugawara F, Sakaguchi K, Mizushina Y: Analysis of cell cycle regulation by 1-mono-O-acyl-3-O-(alpha-D-sulfoquinovosyl)- glyceride (SQMG), an inhibitor of eukaryotic DNA polymerases. Biochem Pharmacol 2003; 66 (4): 541-550.
  25. Mizushina Y X X, Murakami C, Okano T, Takemura M, Yoshida H, Sakaguchi K. Selective inhibition of mammalian DNA polymerase alpha by vitamin D-2 and D-3. J Pharmacol Sci 2003; 92: 283-290.
  26. Nakade Y, Banno Y, Tamiya-Koizumi K, Hagiwara K, Sobue S, Koda M, Suzuki M, Kojima T, Takagi A, Asano H, Nozawa Y, Murate T. Regulation of sphingosine kinase 1 gene expression by protein kinase C in a human leukemia cell line, MEG-O1. Biochim Biophys Acta 2003; 1635:104-116.

2002

  1. Konishi H, Nakagawa T, Harano T, Mizuno K, Saito H, Masuda A, Matsuda H, Osada H, Takahashi T: Identification of frequent G2 checkpoint impairment and a homozygous deletion of 14-3-3ε at 17p13.3 in small cell lung cancers. Cancer Res 2002; 62: 271-276.
  2. Osada H, Tatematsu Y, Yatabe Y, Nakagawa T, Konishi H, Tezel E, Takahashi T: Frequent and histological type-specific inactivation of 14-3-3 σ in human lung cancers. Oncogene 2002; 21: 2418-2424.
  3. Koshikawa K, Osada H, Kozaki K, Konishi H, Masuda A, Tatematsu Y, Nakao A, Takahashi T: Significant up-regulation of a novel gene, CLCP1, in a highly metastatic lung cancer subline as well as in lung cancers in vivo. Oncogene 2002; 21: 2822-2828.
  4. Mizuno K, Osada H, Konishi H, Tatematsu Y, Fujii Y, Takahashi T: Aberrant hypermethylation of the CHFR prophase checkpoint gene in human lung cancers. Oncogene 2002; 21: 2328-2333.
  5. Yatabe Y, Osada H, Tatematsu Y, Mitsudomi T, Takahashi T: Decreased expression of 14-3-3σ in neuroendocrine tumors is independent of origin and malignant potential. Oncogene 2002; 21: 8310-8319.
  6. Yatabe Y, Mitsudomi T, Takahashi T: TTF-1 expression in pulmonary adenocarcinomas. Am J Surg Pathol 2002; 26: 767-773.
  7. Hamajima N, Ito H, Matsuo K, Saito T, Tajima K, Ando M, Yoshida K, Takahashi T: Positive association between smoking habits and dopamine receptor D2 TaqI A polymorphism in Japanese males. J Epidemiol. 2002; 12: 297-304.
  8. Hida T, Kozaki K, Ito H, Miyaishi O, Tatematsu Y, Suzuki M, Seito T, Matsuo K, Sugiura T, Ogawa M, Takahashi T, Takahashi T: Significant growth inhibition of human lung cancer cells both in vitro and in vivo by the combined use of a cyclooxygenase 2-specific inhibitor, JTE-522, and conventional anticancer agents. Clin Cancer Res 2002; 8: 2443-2447.
  9. He Y, Kozaki K, Karpanen T, Koshikawa K, Yla-Herttuala S, Takahashi T, Alitalo K: Suppression of tumor lymphangiogenesis and lymph node metastasis by blocking vascular endothelial growth factor receptor 3 signaling. J Natl Cancer Inst 2002; 94: 785-787.
  10. Murate T, Suzuki M, Hattori M, Takagi A, Kojima T, Tanizawa T, Asano H, Hotta T, Saito H, Yoshida S, Tamiya-Koizumi K: Up-regulation of acid sphingomyelinase during retinoic acid-induced myeloid differentiation of NB4, a human acute promyelocytic leukemia cell line. J Biol Chem 2002; 277:9936-9943.
  11. Suzuki S, Tamai K, Yoshida S: Enzyme-linked immunosorbent assay for distinct cyclin-dependent kinase activities using phosphorylation-site-specific anti-pRb monoclonal antibodies. Anal Biochem 2002; 301:65-74.
  12. Akao Y, Kusakabe S, Banno Y, Kito M, Nakagawa Y, Tamiya-Koizumi K, Hattori M, Sawada M, Hirabayashi Y, Ohishi N, Nozawa Y: Ceramide accumulation is independent of camptothecin-induced apoptosis in prostate cancer LNCaP cells. Biochem Biophys Res Commun 2002; 294:363-370.
  13. Kai T, Matsunaga R, Eguchi M, Kamiya H, Kasai H, Suzuki M, Izuta S: An oxidized nucleotide affects DNA replication through activation of protein kinases in Xenopus egg lysate. Nucleic Acids Res 2002; 30:569-573.
  14. Mizushina Y, Kamisuki S, Shimazaki N, Takemura M, Asahara H, Linn S, Yoshida S, Matsukage A, Koiwai O, Sugawara F, Yoshida H, Sakaguchi K: A plant phytotoxin, solanapyrone A, is an inhibitor of DNA polymerase beta and lambda. J Biol Chem 2002; 277:630-638.
  15. Murakami C, Takemura M, Sugiyama Y, Kamisuki S, Asahara H, Kawasaki M, Ishidoh T, Linn S, Yoshida S, Sugawara F, Yoshida H, Sakaguchi K, Mizushina Y: Vitamin A- related compounds, all-trans retinal and retinoic acids, selectively inhibit activities of mammalian replicative DNA polymerases. Biochim Biophys Acta 2002; 1574:85-92.
  16. Takemura M: Evolution and degeneration of eukaryotic DNA replication system. BioSystems 2002; 65:139-145.
  17. Takemura M, Ohoka F, Perpelescu M, Ogawa M, Matsushita H, Takaba T, Akiyama T, Umekawa H, Furuichi Y, Cook PR, Yoshida S: Phosphorylation-dependent migration of retinoblastoma protein into the nucleolus triggered by binding to nucleophosmin/B23. Exp Cell Res 2002; 276:233-241.
  18. Takemura M: Biochemical properties of the stimulatory activity of DNA polymerase alpha by the hyper-phosphorylated retinoblastoma protein. Biochim Biophys Acta 2002; 1571:151-156.
  19. Perpelescu M, Kobayashi J, Furuta M, Ito Y, Izuta S, Takemura M, Suzuki M, Yoshida S: Novel phenalenone derivatives from a marine-derived fungus exhibit distinct inhibition spectra against eukaryotic DNA polymerases. Biochemistry 2002; 41:7610-7616.
  20. Mizushina Y, Kamisuki S, Kasai N, Ishidoh T, Shimazaki N, Takemura M, Asahara H, Linn S, Yoshida S, Koiwai O, Sugawara F, Yoshida H, Sakaguchi K: Petasiphenol: a DNA polymerase lambda inhibitor. Biochemistry 2002; 41:14463-14471.
  21. Tamiya-Koizumi K, Usukura J, Mihara K, Ishihra H, Hirabayashi Y: Sphingomyelin-metabolic enzymes in Triton X-100-insoluble plasma membrane domains of rat liver and hepatoma cells. Chem Phys lipids 2002; 118: 67-
  22. Yokoi-Ishihara S, Yasui K, Saito-Ohara F, Iizasa T, Fujisawa T, Terasaki T, Horii A, Takahashi T, Hirohashi S, Inazawa J: A novel target gene, SKP2, within the 5p13 amplicon that is frequently detected in small cell lung cancers. Am J Pathol 2002; 161: 207-216.
  23. Martinez J M, Afshari C A, Bushel P R, Masuda A, Takahashi T, Walker N: Differential toxicogenomic responses to 2,3,7,8-tetrachlorodibenzo-p-dioxin in malignant and nonmalignant human airway epithelial cells. Toxicol. Sci. 2002; 69: 409-423.
  24. Kammouni W, Ramkrishna G, Sithanandam G, Smith G T, Fornwald L W, Masuda A, Takahashi T: Anderson L M. Increased K-ras protein and activity in mouse and human lung epithelial cells at confluence. Cell Growth Differ 2002; 13: 441-448.

2001

  1. Osada H, Tatematsu Y, Masuda A, Saito T, Sugiyama M, Yanagisawa K, Takahashi T: Heterogeneous TGF-beta unresponsiveness and loss of TGFbetaRII expression caused by histone deacetylation in lung cancer cell lines. Cancer Res. 2001; 61: 8331-8339.
  2. Kozaki K, Koshikawa K, Tatematsu Y, Miyaishi O, Saito H, Hida T, Osada H, Takahashi T: Multi-faceted analyses of a highly metastatic human lung cancer cell line NCI-H460-LNM35 suggest mimicry of inflammatory cells in metastasis. Oncogene 2001; 20: 4228-4234.
  3. Haruki N, Harano T, Masuda A, Kiyono T, Tatematsu Y, Shimizu S, Mitsudomi T, Konishi H, Osada H, Fujii Y, Takahashi T: Persistent increase in chromosome instability in lung cancer: possible indirect involvement of p53 inactivation. Am J Pathol 2001; 159: 1345-1352.
  4. Masuda A, Osada H, Yatabe Y, Kozaki K, Tatematsu Y, Takahashi T, Hida T, Takahashi T, Takahashi T: Protective function of p27KIP1 against apoptosis in small cell lung cancer cells in unfavorable microenvironments. Am J Pathol 2001; 158: 87-96.
  5. Yoshida K, Hamajima N, Kozaki K, Saito H, Maeno K, Sugiura T, Ookuma K, Takahashi T: Association between the dopamine D2 receptor A2/A2 genotype and smoking behavior in the Japanese. Cancer Epidemiol Biomark & Prev 2001; 10: 403-405.
  6. Matsuoka S, Nakagawa T, Masuda A, Haruki N, Elledge S J, Takahashi T: Reduced expression and impaired kinase activity of a Chk2 mutant identified in human lung cancer. Cancer Res 2001; 61: 5362-5365.
  7. Dammann R, Takahashi T: Pfeifer G P The CpG island of the novel tumor suppressor gene RASSF1A is intensely methylated in primary small cell lung carcinomas. Oncogene 2001; 20: 3563-3567.
  8. Tosaka A, Ogawa M, Yoshida S, Suzuki M: O-helix mutant T664P of Thermus aquaticus DNA polymerase I: altered catalytic properties for incorporation of incorrect but not correct nucleotides. J Biol Chem 2001; 276:27562-27567.
  9. Yoshida K, Tosaka A, Kamiya H, Murate T, Kasai H, Nimura Y, Ogawa M, Yoshida S, Suzuki M: Arg660Ser mutation in Thermus aquaticus DNA polymerase I suppresses T - C transitions; implication of wobble base pair formation at the nucleotide incorporation step. Nucleic Acids Res 2001; 29:4206-4214.
  10. Takemura M, Yamamoto T, Kitagawa M, Taya Y, Akiyama T, Asahara H, Linn S, Suzuki S, Tamai K, Yoshida S: Stimulation of DNA polymerase alpha activity by cdk2-phosphorylated Rb protein. Biochem Biophys Res Commun 2001; 282:984-990.
  11. Mizutani Y, Tamiya-Koizumi K, Nakamura N, Kobayashi M, Hirabayashi Y, Yoshida S: Nuclear localization of neutral sphingomyelinase 1: biochemical and immunocytochemical analyses. J Cell Sci 2001; 114:3727-3736.
  12. Murate T, Banno Y, Tamiya-Koizumi K, Watanabe K, Mori N, Wada A, Igarashi Y, Takagi A, Kojima T, Asano H, Akao Y, Yoshida S, Saito H, Nozawa Y: Cell type-specific localization of sphingosine kinase 1a in human tissues. J Histochem Cytochem 2001; 49:845-855.
  13. Ogawa M, Tosaka A, Itoh Y, Yoshida S, Suzuki M: Enhanced ribonucleotide incorporation by an O-helix mutant of Thermus aquatiqus DNA polymerase I. Mut Res: DNA Repair 2001; 485:197-207.
  14. Okada Y, Tosaka A, Nimura Y, Kikuchi A, Yoshida S, Suzuki M: Atypical multidrug resistance may be associated with catalytically active mutants of human DNA topoisomerase II alpha. Gene 2001; 272:141-148.
  15. Takemura M: Poxviruses and the origin of the eukaryotic nucleus. J Mol Evol 2001; 52:419-425.
  16. Umekawa H, Sato K, Takemura M, Watanabe Y, Usui S, Takahashi T, Yoshida S, Olson MOJ, Furuichi Y: The carboxyl terminal sequence of nucleolar protein B23.1 is important in its DNA polymerase alpha-stimulatory activity. J Biochem 2001; 130:199-205.
  17. Mizushina Y, Sugiyama Y, Yoshida H, Hanashima S, Yamazaki T, Kamisuki S, Ohta K, Takemura M, Yamaguchi T, Matsukage A, Yoshida S, Saneyoshi M, Sugawara F, Sakaguchi K: Galactosyldiacylglycerol, a mammalian DNA polymerase alpha-specific inhibitor from a sea alga, Petalonia bingbamiae. Biol Pharm Bull 2001; 24:982-987.
  18. Ito Y, Tamiya-Koizumi K, Koide Y, Nakagawa M, Kawade T, Nishida A, Murate T, Takemura M, Suzuki M, Yoshida S: Structural requirements of sphingosine molecules for inhibition of DNA primase: Biochemical and computational analyses. Biochemistry 2001; 40:11571-11577.
  19. Takemura M, Yoshida S: Stimulation of DNA polymerase alpha by hyper-gravity generated by centrifugal acceleration. Biochem Biophys Res Commun 2001; 289:345-349.
  20. Haruki N, Saito H, Harano T, Nomoto S, Takahashi T, Osada H, Fujii Y, Takahashi T: Molecular analysis of the mitotic checkpoint genes BUB1, BUBR1 and BUB3 in human lung cancers. Cancer Lett 2001; 162: 201-205.
  21. Toyooka S, Toyooka K, Maruyama R, Virmani A, Girard L, Miyajima K, Harada K, Ariyoshi Y, Takahashi T, Sugio K, Brambilla E, Gilcrease M, Minna J D, Gazdar A F: DNA methylation profiles of lung tumors. Mol Cancer Ther 2001; 1: 61-67

2000

  1. Kozaki K, Miyaishi O, Tsukamoto T, Tatematsu Y, Hida T, Takahashi T, Takahashi T: In vivo selected human lung cancer cell line NCI-H460-LNM35 consistently exhibits lymphogenous metastasis via both subcutaneous and orthotopic propagation. Cancer Res 2000; 60: 2535-2540.
  2. Haruki N, Saito H, Tatematsu Y, Konishi H, HaranoT, Masuda A, Fujii Y. Takahashi T: Histological type-selective, tumor-predominant expression of a novel CHK1 isoform and infrequent in vivo somatic CHK2 mutation in small cell lung cancer. Cancer Res 2000; 60: 4689-4692.
  3. Yanagisawa K, Uchida K, Nagatake M, Masuda A, Sugiyama M, Saito T, Yamaki K, Takahashi T, Osada H: Heterogeneities in the biological and biochemical functions of Smad2 and Smad4 mutants naturally occurring in human lung cancers. Oncogene 2000; 19: 2305-2311.
  4. Yatabe Y, Konishi H, Mitsudomi T, Nakamura S, Takahashi T: Topographical distributions of allelic loss in individual non-small cell lung cancers. Am J Pathol 2000; 157: 985-93.
  5. Okada Y, Ito Y, Kikuchi A, Nimura Y, Yoshida S, Suzuki M: Assignment of functional amino acids around the active site of human DNA topoisomerase IIα. J Biol Chem 2000; 275:24630-24638.
  6. Suzuki M, Yoshida S, Adman ET, Blank A, Loeb LA: Thermus aquaticus DNA polymerase I mutants with altered fidelity: Interacting mutations in the O helix. J Biol Chem 2000; 275:32728-32735.
  7. Shimizu S, Yatabe Y, Koshikawa T, Haruki N, Hatooka S, Shinode M, Suyama M, Ogawa M, Hamajima N, Ueda R, Takahashi T, Mitsudomi T: High frequency of clonally related tumors in cases of multiple synchronous lung cancers as revealed by molecular diagnosis. Clin Cancer Res 2000; 6: 3994-3999.
  8. Mitsudomi T, Hamajima N, Ogawa M, Takahashi T: Prognostic significance of p53 alterations in patients with non-small cell lung cancer: a meta-analysis. Clin Cancer Res 2000; 6: 4055-4063.
  9. Hida T, Kozaki K, Muramatsu H, Masuda A, Shimizu S, Mitsudomi T, Sugiura T, Ogawa M, Takahashi T: Cyclooxygenase (COX)-2 inhibitor induces apoptosis and enhances cytotoxicity of various anticancer agents in non-small cell lung cancer cell lines. Clin Cancer Res 2000; 6: 2006-2011.
  10. Dragani T A, Hirohashi S, Juji T, Kawajiri K, Kihara M, Ono-Kihara M, Manenti G, Nomoto T, Sugimura H, Genka K, Yokota J, Takahashi T, Mitsudomi T, Nagao M: Population-based mapping of pulmonary adenoma susceptibility 1 (PAS1) locus. Cancer Res 2000; 60: 5017-5020.
  11. Mizutani Y, Tamiya-Koizumi K, Irie F, Hirabayashi Y, Miwa M, Yoshida S: Cloning and expression of rat neutral sphingomyelinase: enzymological characterization and identification of essential histidine residues. Biochim Biophys Acta 2000; 1485:236-246.
  12. Mizushina Y, Kamisuki S, Mizuno T, Takemura M, Asahara H, Linn S, Yamaguchi T, Matsukage A, Hanaoka F, Yoshida S, Saneyoshi M, Sugawara F, Sakaguchi K: Dehydroaltenusin, a mammalian DNA polymerase alpha inhibitor. J Biol Chem 2000; 275:33957-33961.
  13. Nomoto S, Haruki N, Tatematsu Y, Konishi H, Mitsudomi T, Takahashi T, Takahashi T: Frequent allelic imbalance suggests the involvement of a tumor suppressor gene at 1p36 in the pathogenesis of human lung cancers. Genes Chrom Cancer 2000; 28:342-346.
  14. Nozawa K, Suzuki M, Takemura M, Yoshida S: In vitro expansion of mammalian telomere repeats by DNA polymerase alpha-primase. Nucleic Acids Res 2000; 28:3117-3124.
  15. Hamajima N, Saito T, Matsuo K, Kozaki K. -K, Takahashi T, Tajima K: Polymerase chain reaction with confronting two-pair primers for polymorphism genotyping. Jpn J Cancer Res 2000; 91: 865-868.
  16. Haruki N, Yatabe Y, Travis W D, Nomoto S, Osada H, Nakamura S, Nakao A, Fujii Y, Takahashi T: Characterization of high-grade neuroendocrine tumors of the lung in relation to menin mutations. Jpn J Cancer Res 2000; 91: 317-323.
  17. Kurumiya Y, Nozawa K, Sakaguchi K, Nagino M, Nimura Y, Yoshida S: Differential suppression of liver-specific genes in regenerating rat liver induced by extended hepatectomy. J Hepatol 2000; 32:636-644.
  18. Nagasaka A, Nakai A, Oda N, Kotake M, Iwase K, Yoshida S: Reverse transcriptase is elevated in the thyroid tissue from Graves' disease patients. Clin Endocrinol 2000; 53:155-159.
  19. Sakaguchi K, Takeuchi E, Suzuki M, Oda K, Nagino M, Nimura Y, Yoshida S: DNA polymerases and Ki-67 nuclear antigen are induced in correlation with the resected mass of rat liver up to 90%. Langenbeck's Arch Surg 2000; 385:135-142.
  20. Suzuki S, Suzuki M, Yoshida S: Characterization of the human DNA polymerase delta catalytic subunit expressed by a recombinant baculovirus. Nagoya J Med Sci 2000; 63:99-113.
  21. Arinaga M, Shimizu S, Gotoh K, Haruki N, Takahashi T, Takahashi T, Mitsudomi T: Expression of human telomerase subunit genes in primary lung cancer and its clinical significance. Ann Thor Surg 2000; 70: 401-405.