Cancer is the leading cause of death in the vast majority of economically developed countries including Japan. The goal of the “Tak” laboratory is to understand the molecular pathogenesis of human solid hard-to-cure cancers, especially lung cancer, and then translate our findings in order to develop novel strategies for better diagnosis, treatment, and prevention. Our current major efforts are focused on the identification of genetic and/or epigenetic “driver” alterations through state-of-the-art expression profiling and bioinformatics analyses of mRNA, ncRNA, and proteins, coupled with elucidation of their detailed biological and biochemical functions, in order to realize our major objective, "from bench to bedside."