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病態内科学呼吸器内科学

研究室概要

肺癌、間質性肺炎、細菌性肺炎、気管支喘息、COPD、気管支鏡検査を中心に、豊富な関連病院を生かした臨床研究とそれを支える基礎研究とがバランスよく機能する研究体制を目指している。肺癌については、癌遺伝子、癌抑制遺伝子の分子生物学的解析や遺伝子治療の基礎研究を行うとともに、オーダーメイド医療の研究を行っている。また、肺癌・間質性肺炎・COPDにおける肺内微小環境に関する研究と分子標的治療の開発、気管支喘息における炎症細胞の解析、呼吸器感染症における新規免疫療法の開発など、幅広い分野の研究を多角的に進めている。

研究プロジェクト

研究紹介などは呼吸器内科独自ホームページ(http://www.med-nagoya-respmed.jp/)もしくはEnglish Web siteをご覧ください。

教員

構成員名役職所属
長谷川 好規 教授 呼吸器内科
佐藤 光夫 講師 呼吸器内科
橋本 直純 講師 呼吸器内科
若原 恵子 病院講師 呼吸器内科
麻生 裕紀 名古屋大学地域包括医療連携モデル事業 病院講師 呼吸器内科、名古屋逓信病院
森瀬 昌宏 医学部附属病院 卒後臨床研修・キャリア形成支援センター 病院助教 呼吸器内科、卒後臨床研修・キャリア形成支援センター
進藤 有一郎 助教 呼吸器内科
長谷 哲成 病院助教 呼吸器内科
阪本 考司 特任助教 呼吸器内科
岡地 祥太郎 病院助教 呼吸器内科
田中 一大 病院助教 呼吸器内科
佐藤 和秀 名古屋大学高等研究院 Selected YLC 特任助教 呼吸器内科、高等研究院

研究実績

  • 2015年
    1. Shindo Y, Ito R, Kobayashi D, Ando M, Ichikawa M, Goto Y, Fukui Y, Iwaki M, Okumura J, Yamaguchi I, Yagi T, Tanikawa Y, Sugino Y, Shindoh J, Ogasawara T, Nomura F, Saka H, Yamamoto M, Taniguchi H, Suzuki R, Saito H, Kawamura T, and Hasegawa Y, on behalf of the Central Japan Lung Study Group. Risk factors for 30-day mortality in patients with pneumonia who receive appropriate initial antibiotics: an observational cohort study. Lancet Infect Dis 2015; 15: 1055-1065.
    2. Yamashita R, Sato M, Kakumu T, Hase T, Yogo N, Maruyama E, Sekido Y, Kondo M, Hasegawa Y. Growth inhibitory effects of miR-221 and miR-222 in non-small cell lung cancer cells. Cancer Med. 2015;4:551-564.
    3. Kusunose M, Hashimoto N, Kimura M, Ogata R, Aoyama D, Sakamoto K, Miyazaki S, Ando A, Omote N, Imaizumi K, Kawabe T, Hasegawa Y Direct regulation of TGFβ-induced EMT by the protein phosphatase activity of unphosphorylated PTEN in lung cancer cells. Cancer Science 2015; 106:1693-1704.
    4. Okachi S, Wakahara K, Kato D, Umeyama T, Yagi T, Hasegawa Y. Massive mediastinal cryptococcosis in young immunocompetent patient. Respirol Case Rep. 2015; 3: 95-98.
    5. Osuka S, Hashimoto N, Sakamoto K, Wakai K, Yokoi K, Hasegawa Y. Risk stratification by the lower limit of normal of FEV1/FVC for postoperative outcomes in patients with COPD undergoing thoracic surgery. Respir Investig 2015; 53:117-123.
    6. Andruska A, Micek S, Shindo Y, Hampton N, Colona B, McCormick S, Kollef M. Pneumonia pathogen characterization is an independent determinant of hospital readmission. Chest 2015; 148: 103-111.
    7. Enomoto Y, Kenmotsu H, Watanabe N, Baba T, Murakami H, Yoh K, Ogura T, Takahashi T, Goto K, Kato T. Efficacy and Safety of Combined Carboplatin, Paclitaxel, and Bevacizumab for Patients with Advanced Non-squamous Non-small Cell Lung Cancer with Pre-existing Interstitial Lung Disease: A Retrospective Multi-institutional Study. Anticancer Res. 2015;35:4259-4263.
    8. Hanaoka H, Nakajima T, Sato K, Watanabe R, Phung Y, Gao W, Harada T, Kim I, Paik CH, Choyke PL, Ho M, Kobayashi H. Photoimmunotherapy of hepatocellular carcinoma-targeting Glypican-3 combined with nanosized albumin-bound paclitaxel. Nanomedicine (Lond). 2015;10:1139-1147.
    9. Hanaoka H, Nagaya T, Sato K, Nakamura Y, Watanabe R, Harada T, Gao W, Feng M, Phung Y, Kim I, Paik CH, Choyke PL, Ho M, Kobayashi H. Glypican-3 targeted human heavy chain antibody as a drug carrier for hepatocellular carcinoma therapy. Mol Pharm. 2015;12:2151-2157.
    10. Ito R, Shindo Y, Kobayashi D, Ando M, Jin W, Wachino J, Yamada K, Kimura K, Yagi T, Hasegawa Y, and Arakawa Y. Molecular Epidemiological Characteristics of Klebsiella pneumoniae Associated with Bacteremia among Patients with Pneumonia. J Clin Microbiol 2015; 53: 879-886.
    11. Kawakami K, Iwano S, Hashimoto N, Hasegawa Y, Naganawa S. Evaluation of emphysema using three-dimensional computed tomography: association with postoperative complications in lung cancer patients. Nagoya J Med Sci. 2015; 77:113-122.
    12. Kim J, Sato M, Choi JW, Kim HW, Yeh BI, Larsen JE, Minna JD, Cha JH, Jeong Y. Nuclear Receptor Expression and Function in Human Lung Cancer Pathogenesis. PLoS One. 2015 Aug 5;10:e0134842.
    13. Kondoh Y, Johkoh T, Fukuoka J, Arakawa H, Tanaka T, Watanabe N, Sakamoto K, Kataoka K, Kimura T, Taniguchi H. Broader criteria of undifferentiated connective tissue disease in idiopathic interstitial pneumonias. Respir Med. 2015;109:389-396.
    14. Koriyama H, Ishii G, Yoh K, Neri S, Morise M, Umemura S, Matsumoto S, Niho S, Ohmatsu H, Tsuboi M, Goto K, Ochiai A. Presence of podoplanin-positive cancer-associated fibroblasts in surgically resected primary lung adenocarcinoma predicts a shorter progression-free survival period in patients with recurrences who received platinum-based chemotherapy. J Cancer Res Clin Oncol. 2015;141:1163-70.
    15. Minezawa T, Okamura T, Yatsuya H, Yamamoto N, Morikawa S, Yamaguchi T, Morishita M, Niwa Y, Takeyama T, Mieno Y, Hoshino T, Uozu S, Goto Y, Hayashi M, Isogai S, Matsuo M, Nakanishi T, Hashimoto N, Okazawa M, Imaizumi K. Bronchus sign on thin-section computed tomography is a powerful predictive factor for successful transbronchial biopsy using endobronchial ultrasound with a guide sheath for small peripheral lung lesions: a retrospective observational study. BMC Medical Imaging 2015; 21;15-21.
    16. Morise M, Hishida T, Takahashi A, Yoshida J, Ohe Y, Nagai K, Ishii G. Clinicopathological significance of cancer stem-like cell markers in high-grade neuroendocrine carcinoma of the lung. J Cancer Res Clin Oncol. 2015;141:2121-30.
    17. Nagaya T, Sato K, Harada T, Nakamura Y, Choyke PL, Kobayashi H. Near Infrared Photoimmunotherapy Targeting EGFR Positive Triple Negative Breast Cancer: Optimizing the Conjugate-Light Regimen. PLoS One. 2015;10:e0136829.
    18. Omote N, Taniguchi H, Kondoh Y, Watanabe N, Sakamoto K, Kimura T, Kataoka K, Johkoh T, Fujimoto K, Fukuoka J, Otani K, Nishiyama O, Hasegawa Y. Lung-dominant connective tissue disease: clinical, radiologic and histologic features. Chest. 2015;148:1438-1446
    19. Sarfati M, Wakahara K, Chapuy L, Delespesse G. Mutual interaction of basophils and T cells in choronic infalammatory diseases. Front Immunol. 2015; 6:399. [Review]
    20. Sato K, Hanaoka H, Watanabe R, Nakajima T, Choyke PL, Kobayashi H. Near infrared photoimmunotherapy in the treatment of disseminated peritoneal ovarian cancer. Mol Cancer Ther. 2015;14:141-150.
    21. Sato K, Nagaya T, Choyke PL, Kobayashi H. Near infrared photoimmunotherapy in the treatment of pleural disseminated NSCLC: preclinical experience. Theranostics 2015; 5: 698-709.
    22. Sato K, Nakajima T, Choyke PL, Kobayashi H. Selective cell elimination in vitro and in vivo from tissues and tumors using antibodies conjugated with a near infrared phthalocyanine. RSC Adv. 2015;5:25105-25114.
    23. Sato K, Nagaya T, Nakamura Y, Harada T, Choyke PL, Kobayashi H. Near infrared photoimmunotherapy prevents lung cancer metastases in a murine model. Oncotarget. 2015:19747-19758.
    24. Sato K, Nagaya T, Mitsunaga M, Choyke PL, Kobayashi H. Near infrared photoimmunotherapy for lung metastases. Cancer Lett. 2015;365:112-121.
    25. Sato K, Nagaya T, Nakamura Y, Harada T, Nani RR, Shaum JB, Gorka AP, Kim I, Paik CH, Choyke PL, Schnermann MJ, Kobayashi H. Impact of C4'-O-Alkyl Linker on in Vivo Pharmacokinetics of Near-Infrared Cyanine/Monoclonal Antibody Conjugates. Mol Pharm. 2015;12:3303-3311.
    26. Shindo Y, Unsinger J, Burnham C, Green J, and Hotchkiss R. Interleukin 7 and anti-programmed cell death 1 antibody have differing effects to reverse sepsis-induced immunosuppression. Shock 2015; 43: 334-343.
    27. Udagawa H, Ishii G, Morise M, Umemura S, Matsumoto S, Yoh K, Niho S, Ohmatsu H, Tsuboi M, Goto K, Ochiai A, Ohe Y. Comparison of the expression levels of molecular markers among the peripheral area and central area of primary tumor and metastatic lymph node tumor in patients with squamous cell carcinoma of the lung. J Cancer Res Clin Oncol. 2015;141:1417-25.
    28. Wakayama H, Hashimoto N, Matsushita Y, Matsubara K, Yamamoto N, Hasegawa Y, Ueda M, Yamamoto A. Factors secreted from dental pulp stem cells show multifaceted benefits for treating acute respiratory distress syndrome in mice. Cytotherapy 2015; 17: 1119-1129.
    29. Watanabe N, Niho S, Kirita K, Umemura S, Matsumoto S, Yoh K, Ohmatsu H, Goto K.  Second-line docetaxel for patients with platinum-refractory advanced non-small cell lung cancer and interstitial pneumonia. Cancer Chemother Pharmacol. 2015;76(1):69-74.
    30. Watanabe N, Niho S, Kirita K, Umemura S, Matsumoto S, Yoh K, Ohmatsu H, Goto K. Vinorelbine and Cisplatin in Patients with Advanced Non-small Cell Lung Cancer with Interstitial Pneumonia. Anticancer Res. 2015;35:1697-1701.
    31. Watanabe N, Umemura S, Niho S, Kirita K, Matsumoto S, Yoh K, Ohmatsu H, Goto K. Docetaxel for platinum-refractory advanced thymic carcinoma. Jpn J Clin Oncol. 2015; 45:665-669.
    32. Watanabe R, Hanaoka H, Sato K, Nagaya T, Harada T, Mitsunaga M, Kim I, Paik CH, Wu AM, Choyke PL, Kobayashi H. Photoimmunotherapy targeting prostate-specific membrane antigen: are antibody fragments as effective as antibodies? J Nucl Med. 2015 Jan;56:140-144.
  • 2014年
    1. Chapuy L, Bsat M, Mehta H, Rubio M, Wakahara K, Van VQ, Baba N, Cheong C, Yun TJ, Panzini B, Wassef R, Richard C, Tamaz R, Soucy G, Delespesse G, Sarfati M. Basophils increase in Crohn disease and ulcerative colitis and favor mesenteric lymph node memory TH17/TH1 response. J Allergy Clin Immunol. 2014; 134 (4): 978-981.
    2. Fukatsu A, Ishiguro F, Tanaka I, Kudo T, Nakagawa K, Shinjo K, Kondo Y, Fujii M, Hasegawa Y, Tomizawa K, Mitsudomi T, Osada H, Hata Y, Sekido Y. RASSF3 downregulation increases malignant phenotypes of non-small cell lung cancer. Lung Cancer 2014; 83: 23-29.
    3. Fukihara J, Watanabe N, Taniguchi H, Kondoh Y, Kimura T, Kataoka K, Matsuda T, Yokoyama T, Hasegawa Y. Clinical predictors of response to EGFR tyrosine kinase inhibitors in patients with EGFR-mutant non-small cell lung cancer. Oncology 2014; 86(2): 86-93.
    4. Hashimoto N, Matsuzaki A, Okada Y, Imai N, Iwano S, Wakai K, Imaizumi K, Yokoi K, Hasegawa Y. Clinical impact of prevalence and severity of COPD on the decision-making process for therapeutic management of lung cancer patients. BMC Pulm Med 2014; 14(1): 14.
    5. Kitano M, Iwano S, Hashimoto N, Matsuo K, Hasegawa Y, Naganawa S. Lobar analysis of collapsibility indices to assess functional lung volumes in COPD patients. Int J Chron Obstruct Pulmon Dis 2014; 9: 1347-1356.
    6. Morise M, Taniguchi H, Saka H, Shindoh J, Suzuki R, Kojima E, Hase T, Ando M, Kondo M, Saito H, Hasegawa Y. Phase II study of erlotinib for previously treated patients with EGFR wild-type non-small-cell lung cancer, following EGFR mutation status reevaluation with the Scorpion Amplified Refractory Mutation System. Mol Clin Oncol. 2014; 2: 991-996.
    7. Morise M, Niho S, Umemura S, Matsumoto S, Yoh K, Goto K, Ohmatsu H, Ohe Y. Low-dose irinotecan as a second-line chemotherapy for recurrent small cell lung cancer. Jpn J Clin Oncol. 2014; 44: 846-851.
    8. Murata N, Ito S, Furuya K, Takahara N, Naruse K, Aso H, Kondo M, Sokabe M, Hasegawa Y. Ca2+ influx and ATP release mediated by mechanical stretch in human lung fibroblasts. Biochem Biophys Res Commun 2014; 453: 101-105.
    9. Noble PD, Pascoe CD, Bo L, Ito S, Kistemaker LE, Tatler AL, Pera T, Brook BS, Gosens R, West AR. Airway smooth muscle in asthma: linking contraction and mechanotransduction to disease pathogenesis and remodeling. Pulm Pharmacol Ther 2014; 29: 96-107. [Review]
    10. Ogawa T, Imaizumi K, Hashimoto I, Shindo Y, Imai N, Uozu S, Shimokata T, Ito S, Hashimoto N, Sato M, Kondo M, Hasegawa Y. Prospective analysis of efficacy and safety of an individualized-midazolam-dosing protocol for sedation during prolonged bronchoscopy. Respir Investig 2014; 52: 153-159.
    11. Shindo Y, Hasegawa Y. Reply: HCAP Not Busy Being Born Is Busy Dying. Am J Respir Crit Care Med 2014; 189 (3): 366-367.
    12. Shindo Y, Hasegawa Y. Reply: Isolation of drug-resistant pathogens does not always require antibiotics of broad spectrum in pneumonia. Am J Respir Crit Care Med 2014; 189(6): 757-758.
    13. Suzuki A, Taniguchi H, Watanabe N, Kondoh Y, Kimura T, Kataoka K, Matsuda T, Yokoyama T, Sakamoto K, Nishiyama O, Hasegawa Y. Significance of pulmonary arterial pressure as a prognostic indicator in lung-dominant connective tissue disease. PLoS One 2014; 9(9): e108339.
    14. Takahara N, Ito S, Furuya K, Naruse K, Aso H, Kondo M, Sokabe M, Hasegawa Y. Real-time imaging of ATP release induced by mechanical stretch in human airway smooth muscle cells. Am J Respir Cell Mol Biol 2014; 51: 772-782.
    15. Takahashi K, Saito H, Hasegawa Y, Ando M, Yamamoto M, Kojima E, Sugino Y, Kimura T, Nomura F, Ogasawara T, Shindoh J, Yoshida N, Suzuki R. First-line gefitinib therapy for elderly patients with non-small cell lung cancer harboring EGFR mutation: Central Japan Lung Study Group 0901. Cancer Chemother Pharmacol. 2014; 74(4): 721-727.
    16. Takashima K, Matsushima M, Hashimoto K, Nose H, Sato M, Hashimoto N, Hasegawa Y, Kawabe T. Protective effects of intratracheally administered quercetin on lipopolysaccharide-induced acute lung injury. Respiratoy Research 2014; 15(1): 150.
    17. Umemura S, Mimaki S, Makinoshima H, Tada S, Ishii G, Ohmatsu H, Niho S, Yoh K, Matsumoto S, Takahashi A, Morise M, Nakamura Y, Ochiai A, Nagai K, Iwakawa R, Kohno T, Yokota J, Ohe Y, Esumi H, Tsuchihara K, Goto K. Therapeutic priority of the PI3K/AKT/mTOR pathway in small cell lung cancers as revealed by a comprehensive genomic analysis. J Thorac Oncol. 2014; 9: 1324-1331.
    18. Watanabe N, Taniguchi H, Kondoh Y, Kimura T, Kataoka K, Nishiyama O, Kondo M, Hasegawa Y. Chemotherapy for extensive-stage small-cell lung cancer with idiopathic pulmonary fibrosis. Int J Clin Oncol 2014; 19(2): 260-265.
    19. Watanabe N, Nakahara Y, Taniguchi H, Kimura T, Kondoh Y, Kataoka K, Sakamoto K. Crizotinib-induced acute interstitial lung disease in a patient with EML4-ALK positive non-small cell lung cancer and chronic interstitial pneumonia. Acta Oncol 2014; 53:158-160.
    20. Watanabe N, Sakamoto K, Taniguchi H, Kondoh Y, Kimura T, Kataoka K, Ono K, Fukuoka J, Nishiyama O, Hasegawa Y. Efficacy of combined therapy with cyclosporin and low-dose prednisolone in interstitial pneumonia associated with connective tissue disease. Respiration 2014; 87(6): 469-477.
    21. Wu W, Ichihara G, Hashimoto N, Hasegawa Y, Hayashi Y, Tada-Oikawa S, Suzuki Y, Chang J, Kato M, D'Alessandro-Gabazza CN, Gabazza EC, Ichihara S. Synergistic Effect of Bolus Exposure to Zinc Oxide Nanoparticles on Bleomycin-Induced Secretion of Pro-Fibrotic Cytokines without Lasting Fibrotic Changes in Murine Lungs. Int J Mol Sci. 2014; 16(1): 660-676.
  • 2013年
    1. Aoyama D, Hashimoto N, Sakamoto K, Kohnoh T, Kusunose M, Kimura M, Ogata R, Imaizumi K, Kawabe T, Hasegawa Y. Involvement of TGFβ-induced phosphorylation of the PTEN C-terminus on TGFβ-induced acquisition of malignant phenotypes in lung cancer cells. Plos One 2013;8(11): e81133.
    2. Aso H, Ito S, Mori A, Suganuma N, Morioka M, Takahara N, Kondo M, Hasegawa Y. Differential regulation of airway smooth muscle cell migration by E-prostanoid receptor subtypes. Am J Respir Cell Mol Biol 2013;48(3):322-329.
    3. Baba N, Van VQ, Wakahara K, Rubio M, Fortin G, Panzini B, Soucy G, Wassef R, Richard C, Tamaz R, Lahaie R, Bernard EJ, Caussignac Y, Leduc R, Lougnarath R, Bergeron C, Racicot MA, Bergeron F, Panzini MA, Demetter P, Franchimont D, Schäkel K, Weckbecker G, Kolbinger F, Heusser C, Huber T, Welzenbach K, Sarfati M. CD47 fusion protein targets CD172a+ cells in Crohn's disease and dampens the production of IL-1β and TNF. J Exp Med 2013;210(6):1251-1263.
    4. Billington CK, Ojo OO, Penn RB, Ito S. cAMP regulation of airway smooth muscle function. Pulm Pharmacol Ther 2013;6:112-120. [Review]
    5. Hashimoto I, Imaizumi K, Hashimoto N, Furukawa H, Noda Y, Kawabe T, Honda T, Ogawa T, Matsuo M, Imai N, Ito S, Sato M, Kondo M, Shimokata K, Hasegawa Y. Aqueous fraction of Sauropus androgynus might be responsible for bronchiolitis obliterans. Respirology 2013;18(2):340-347.
    6. Imai N, Imaizumi K, Ando M, Shimokata T, Ogawa T, Ito S, Hashimoto N, Sato M, Kondo M, Hasegawa Y. Echoic features of lymph nodes with sarcoidosis determined by endobronchial ultrasound. Intern Med 2013;52(13):1473-1478.
    7. Kimura M, Taniguchi H, Kondoh Y, Kimura T, Kataoka K, Nishiyama O, Aso H, Sakamoto K, Hasegawa Y. Pulmonary hypertension as a prognostic indicator at the initial evaluation in idiopathic pulmonary fibrosis. Respiration 2013;85(6):456-463.
    8. Nakagawa T, Takeuchi S, Yamada T, Ebi H, Sano T, Nanjo S, Ishikawa D, Sato M, Hasegawa Y, Sekido Y, Yano S. EGFR-TKI resistance due to BIM polymorphism can be circumvented in combination with HDAC inhibition. Cancer Res 2013;73(8):2428-2434.
    9. Nakagawa T, Takeuchi S, Yamada T, Ebi H, Sano T, Nanjo S, Ishikawa D, Sato M, Hasegawa Y, Sekido Y, Yano S. EGFR-TKI resistance due to BIM polymorphism can be circumvented in combination with HDAC inhibition. Cancer Res 2013;73(8):2428-2434.
    10. Nishimura K, Mitsuma S, Kobayashi A, Yanagida M, Nakayasu K, Hasegawa Y, Jones PW. COPD and disease-specific health status in a working population. Respir Res 2013;14:61.
    11. Oguri T, Mitsuma A, Inada-Inoue M, Morita S, Shibata T, Shimokata T, Sugishita M, Nakayama G, Uehara K, Hasegawa Y, Ando Y. Genetic polymorphisms associated with oxaliplatin-induced peripheral neurotoxicity in Japanese patients with colorectal cancer. International Journal of clinical pharmacology and therapeutics 2013;51(6):475-481.
    12. Ohno T, Okamoto M, Hara T, Hashimoto N, Imaizumi K, Matsushima M, Nishimura M, Shimokata K, Hasegawa Y, Kawabe T. Detection of loci for allergic asthma using SMXA recombinant inbred strains of mice. Immunogenetics 2013; 65(1):17-24.
    13. Okachi S, Imai N, Imaizumi K, Hase T, Shindo Y, Sakamoto K, Aso H, Wakahara K, Hashimoto I, Ito S, Hashimoto N, Sato M, Kondo M, Hasegawa Y. Endobronchial ultrasound transbronchial needle aspiration in older people. Geriatr Gerontol Int. 2013;13(4):986-92.
    14. Osborne JK, Larsen JE, Gonzales JX, Shames DS, Sato M, Wistuba II, Girard L, Minna JD, Cobb MH. NeuroD1 regulation of migration accompanies the differential sensitivity of neuroendocrine carcinomas to TrkB inhibition. Oncogenesis 2013;19;2:e63
    15. Osborne JK, Larsen JE, Shields MD, Gonzales JX, Shames DS, Sato M, Kulkarni A, Wistuba II, Girard L, Minna JD, Cobb MH. NeuroD1 regulates survival and migration of neuroendocrine lung carcinomas via signaling molecules TrkB and NCAM. Proc Natl Acad Sci U S A. 2013;110(16): 6524-6529.
    16. Sato M, Larsen JE, Lee W, Sun H, Shames DS, Dalvi MP, Ramirez RD, Tang H, DiMaio JM, Gao B, Xie Y, Wistuba II, Gazdar AF, Shay JW, Minna JD. Human lung epithelial cells progressed to malignancy through specific oncogenic manipulations. Mol Cancer Res. 2013;11(6):638-50.
    17. Shindo Y, Ito R, Kobayashi D, Ando M, Ichikawa M, Shiraki A, Goto Y, Fukui Y, Iwaki M, Okumura J, Yamaguchi I, Yagi T, Tanikawa Y, Sugino Y, Shindoh J, Ogasawara T, Nomura F, Saka H, Yamamoto M, Taniguchi H, Suzuki R, Saito H, Kawamura T, Hasegawa Y. Risk Factors for Drug-Resistant Pathogens in Community-Acquired and Healthcare-Associated Pneumonia. Am J Respir Crit Care Med 2013;188:985-995.
    18. Sunaga N, Kaira K, Imai H, Shimizu K, Nakano T, Shames DS, Girard L, Soh J, Sato M, Iwasaki Y, Ishizuka T, Gazdar AF, Minna JD, Mori M. Oncogenic KRAS-induced epiregulin overexpression contributes to aggressive phenotype and is a promising therapeutic target in non-small-cell lung cancer. Oncogene. 2013;32(34):4034-42.
    19. Taga S, Taniguchi H, Watanabe N, Kondoh Y, Kimura T, Kataoka K, Aso H, Sakamoto K, Hasegawa Y. Predictors of the need to initiate noninvasive ventilation in stable outpatients with acute exacerbation of chronic obstructive pulmonary disease. Intern Med. 2013;52:1781-1786.
    20. Takahashi N, Kondo T, Fukuta M, Takemoto A, Takami Y, Sato M, Ando T, Hashimoto N, Suzuki T, Sato J, Yamamura M, Ban N. Selective IgA deficiency mimicking Churg-Strauss syndrome and hypereosinophilic syndrome: a case report. Nagoya J Med Sci 2013;75(1-2):139-46.
    21. Tsukuura H, Nishimura K, Taniguchi H, Kondoh Y, Kimura T, Kataoka K, Watanabe N, Hasegawa Y. Opioid Use in End-of-Life Care in Patients With Interstitial Pneumonia Associated With Respiratory Worsening. Journal of Pain Palliat Care Pharmacother 2013;27:214-219.
    22. Uchida A, Ito S, Suki B, Matsubara H, Hasegawa Y. Influence of cheek support on respiratory impedance measured by forced oscillation technique. Springer Plus 2013;2:342.
    23. Wakahara K, Van VQ, Baba N, Bégin P, Rubio M, Delespesse G, Sarfati M. Basophils are recruited to inflamed lungs and exacerbate memory Th2 responses in mice and humans. Allergy 2013; 68(2):180-9.
    24. Watanabe F, Taniguchi H, Sakamoto K, Kondoh Y, Kimura T, Kataoka K, Ogawa T, Arizono S, Nishiyama O, Hasegawa Y. Quadriceps weakness contributes to exercise capacity in nonspecific interstitial pneumonia. Respiratory medicine 2013;107:622-628.
    25. Watanabe N, Taniguchi H, Kondoh Y, Kimura T, Kataoka K, Nishiyama O, Kondo M, Hasegawa Y. Efficacy of chemotherapy for advanced non-small cell lung cancer with idiopathic pulmonary fibrosis. Respiration 2013;85-4:326-331.
    26. Yoshida K, Sato M, Hase T, Elshazley M, Yamashita R, Usami N, Taniguchi T, Yokoi K, Nakamura S, Kondo M, Girard L, Minna JD, Hasegawa Y. TIMELESS is overexpressed in lung cancer and its expression correlates with poor patient survival. Cancer Sci 2013;104(2):171-177.

研究キーワード

肺癌、悪性胸膜中皮腫、間質性肺炎、肺線維症、慢性閉塞性肺疾患(COPD)、肺気腫、気管支喘息、肺炎、呼吸器感染症、急性呼吸不全、慢性呼吸不全、遺伝子治療、分子標的治療、免疫療法、オーダーメイド医療