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病態内科学糖尿病・内分泌内科学

研究室概要

当科は２００３年に第一内科内分泌研究室と第三内科糖尿病研究室が合併し、さらに糖尿病の臨床を担当していた第二内科の先生方も加わって、糖尿病・内分泌内科教室として新たに発足しました。伝統的に東海地区の糖尿病・内分泌の臨床と研究をリードしてきた研究室を母体とする当科では、３５の関連施設病院と連携しながら糖尿病や肥満症などの生活習慣病と種々の内分泌疾患について診療および研究を行っています。また、２０１５年８月には有馬寛先生が当科の教授に就任し、教室員が一丸となってさらなる発展を目指しています。

研究プロジェクト

１．バソプレシンに関する基礎研究

抗利尿ホルモンであるバソプレシンは視床下部で産生、下垂体後葉で貯蔵され、浸透圧の上昇や循環血漿量の低下が刺激となり体循環に分泌されます。このバソプレシン分泌調節が障害されると、中枢性尿崩症や抗利尿ホルモン不適切分泌症候群（SIADH）の原因となります。仮面尿崩症は、中枢性尿崩症と副腎不全を合併すると多尿が不顕性化されることで知られている病態ですが、その詳細な機序は不明です。現在、グルココルチコイドがバソプレシン分泌に与える影響を検討することで、仮面尿崩症の発症機序の解明に向けた研究を行っています。また、遺伝性の中枢性尿崩症である家族性中枢性尿崩症のモデルマウスを解析し、その病態解明にも取り組んでいます。

２．視床下部・下垂体の再生医療

視床下部や下垂体の機能がひとたび失われると、回復することは殆どありません。当科では、視床下部神経や下垂体前葉細胞の再生医療を実現すべく技術開発を進めています。ES細胞やiPS細胞を材料に、視床下部・下垂体の胎児発生を手本にしてそれを試験管内で立体的に再現する方法で、視床下部組織や下垂体組織を作り出します。臨床で移植治療に用いることが可能になるように、製法、移植法、品質管理法を開発し、安全性試験、効果効能試験に取り組んでいます。また、この技術を応用して、疾患特異的iPS細胞を用いた遺伝子疾患の病態解析、ヒト胎児発生のモデル化、老化を含めたライフコースの再現、視床下部や下垂体の組織幹細胞の創出、サーカディアンリズムを含めた広汎な視床下部機能の再現などに挑戦しています。

３．AIを用いた低ナトリウム血症の診断および治療に関する臨床研究

低ナトリウム血症は、循環血漿量の増加、ほぼ正常、低下の3種類に分類されます。それぞれ治療が異なるため鑑別は重要ですが、実臨床では循環血漿量の適切に評価することが難しいために、低ナトリウム血症の鑑別にしばしば難渋するケースがあります。当研究室では、低ナトリウム血症とその治療に関する実態調査を行い、その解析にAIを用いることで、新たな低ナトリウム血症の鑑別方法の確立に向けた研究を行っています。また、重症低ナトリウム血症では意識障害やけいれんなどの重篤な中枢神経症状の原因となることから早急な治療を要しますが、短時間で過度な血清ナトリウム濃度の上昇は浸透圧性脱髄症候群の誘因となることが知られています。したがって、重症低ナトリウム血症の治療では、血清ナトリウム濃度を早急に補正する必要がある一方で、浸透圧性脱髄症候群の予防のために血清ナトリウム濃度を過度に上昇させてはならないというジレンマが問題となります。当研究室では，機械学習を用いた重症低ナトリウム血症治療予測システムを構築することで，従来よりも安全な低ナトリウム血症の治療プロトコールの開発に繋げることを目標としています。

４．肥満・糖尿病の病態研究

エネルギーバランスは脳（中枢）によって調節されています。生活習慣病の原因である肥満症は、既にパンデミックレベルで蔓延しているにも関わらず有効な内科的治療法は未だ確立しておらず、発症機序の解明および治療法の確立が期待されます。我々はストレスによる過食、高脂肪食摂取による肥満、高脂肪食と高塩分摂取による糖・エネルギー代謝異常に加え、中枢による糖代謝調節機構について様々な遺伝子改変マウスを用いて研究しています。

５．免疫チェックポイント阻害薬による内分泌有害事象に関する基礎および臨床研究

免疫チェックポイント阻害薬（ICIs）は、進行悪性腫瘍に対して広く使用されるようになりましたが、自己免疫機序の関与が示唆される免疫関連有害事象（irAEs）の発生が課題となっています。irAEsは、肺、消化管、皮膚、内分泌器官など全身の臓器で生じ、内分泌irAEsでは、下垂体、甲状腺、副腎皮質、膵、副甲状腺の機能障害が報告されています。拡大するICIsを用いたがん免疫療法において、irAEs対策は極めて重要ですが、内分泌有害事象の臨床的特徴や発症機序の詳細は明らかではありません。我々は、ICIsによる内分泌irAEsの特徴を明らかにするため、名大病院でICIsを使用する全例を対象とした前向き臨床研究を現在行っています。最近では、抗PD-1抗体であるニボルマブによる甲状腺障害の特徴を明らかにし、抗甲状腺抗体を評価することで甲状腺障害発症の高リスク患者を治療前に判別できる指標を見いだしまし。また、抗CTLA-4抗体、抗PD-1抗体による下垂体炎、甲状腺炎のマウスモデルを新たに開発し、発症機序の検討も行っています。irAEsの基礎および臨床研究は、より安全ながん免疫療法の開発に加え、原因が明らかではない自己免疫性内分泌疾患の発症機序の解明にも繋がる可能性があると考えています。

６．糖尿病、肥満症を中心とした臨床研究

関連医療機関と連携して１型糖尿病に関するデータベースを構築し、１型糖尿病の実態を明らかにする臨床観察研究に取り組んでいます。２型糖尿病についてもIoT・AI・アプリケーションなどの情報通信技術や最新の医療機器を駆使して生活習慣の改善をめざす臨床介入研究を行っています。最近では、インスリン使用患者にのみ保険適応となっている血糖測定器「フラッシュグルコースモニタリング」がインスリンを使用していない2型糖尿病患者においても糖代謝改善に有用であることを報告しています。また、肥満症を対象とし、呼気ガス測定器を用いて各個人の基礎代謝を把握することで、基礎代謝の回復を促しながら持続可能な減量を目指す研究にも取り組んでいます。

教員

構成員名役職所属
有馬 寛 教授 糖尿病・内分泌内科学
坂野 僚一 准教授 保体センター
須賀 英隆 准教授 糖尿病・内分泌内科学
岩間 信太郎 講師 糖尿病・内分泌内科学
萩原　大輔 病院講師 糖尿病・内分泌内科学
尾上 剛史 病院講師 卒後臨床研修・キャリア形成支援センター
安田　康紀 助教 糖尿病・内分泌内科学
杉山 摩利子 助教 糖尿病・内分泌内科学
小林　朋子 病院助教 糖尿病・内分泌内科学
宮田　崇 特任助教 CKD先進診療システム学寄附講座科学

研究実績

  • 2023年
    1. Kobayashi T, Iwata T, Handa K, Arima H. Pyogenic spondylitis due to Streptococcus agalactiae with paraspinal abscess and vertebral destruction in a diabetic patient: time course of imagings. Endocrinol Diabetes and Metab Case Rep. 2023; 78(4): 349-358
    2. Handa T, Onoue T, Kobayashi T, Wada E, Hayase A, Kinoshita T, Yamagami A, Yasuda Y, Iwama S, Kawaguchi Y, Miyata T, Sugiyama M, Takagi H, Hagiwara D, Suga H, Banno R, Goto M, Arima H. Resting energy expenditure depends on energy intake during weight loss in people with obesity: a retrospective cohort study. Arch Endocrinol Metab. 2023; 67(2): 233-241
    3. Miwata T, Suga H, Kawaguchi Y, Sakakibara M, Kano M, Taga S, Soen M, Ozaki H, Asano T, Sasaki H, Miyata T, Yasuda Y, Kobayashi T, Sugiyama M, Onoue T, Takagi H, Hagiwara D, Iwama S, Arima H. Generation of hypothalamic neural stem cell-like cells in vitro from human pluripotent stem cells. Stem Cell Reports 2023; 18(4): 869-883
    4. Ito Y, Sun R, Yaginuma H, Taki K, Mizoguchi A, Kobayashi T, Sugiyama M, Onoue T, Tsunekawa T, Takagi H, Hagiwara D, Iwama S, Suga H, Konishi H, Kiyama H, Arima H, Banno R. Protein Tyrosine Phosphatase 1B Deficiency Improves Glucose Homeostasis in Type 1 Diabetes Treated With Leptin. Diabetes 2023; 71(9): 1902-1914
    5. Ito M, Iwama S, Sugiyama D, Yasuda Y, Okuji T, Kobayashi T, Zhou X, Yamagami A, Onoue T, Miyata T, Sugiyama M, Hagiwara D, Suga H, Banno R, Nishikawa H, Arima H. Anti-tumor effects of anti-programmed cell death-1 antibody treatment are attenuated in streptozotocin-induced diabetic mice. Sci Rep. 2023; 13(1): 5939
    6. Zhou X, Iwama S, Kobayashi T, Ando M, Arima H. The risk of thyroid dysfunction in PD-1 blockade is stratified by the pattern of TgAb and TPOAb positivity at baseline. J Clin Endocrinol Metab. 2023; dgad231
    7. Taga S, Suga H, Nakano T, Kuwahara A, Inoshita N, Kodani Y, Nagasaki H, Sato Y, Tsumura Y, Sakakibara M, Soen M, Miwata T, Ozaki H, Kano M, Watari K, Ikeda A, Yamanaka M, Takahashi Y, Kitamoto S, Kawaguchi Y, Miyata T, Kobayashi T, Sugiyama M, Onoue T, Yasuda Y, Hagiwara D, Iwama S, Tomigahara Y, Kimura T, Arima H. Generation and purification of ACTH-secreting hPSC-derived pituitary cells for effective transplantation. Stem Cell Reports. 2023; 18: 1-15
    8. Kobayashi T, Iwama S, Arima H. Clinical characteristics and potential biomarkers of thyroid and pituitary immune-related adverse events. Endocr J. 2023 Online ahead of print
  • 2022年
    1. Iwama S, Kobayashi T, Yasuda Y, Okuji T, Ito M, Ando M, Zhou X, Yamagami A, Onoue T, Kawaguchi Y, Miyata T, Sugiyama M, Takagi H, Hagiwara D, Suga H, Banno R, Hase T, Morise M, Wakahara K, Yokota K, Kato M, Nishio N, Tanaka C, Miyata K, Ogura A, Ito T, Sawada T, Shimokata T, Niimi K, Ohka F, Ishigami M, Gotoh M, Hashimoto N, Saito R, Kiyoi H, Kajiyama H, Ando Y, Hibi H, Sone M, Akiyama M, Kodera Y, Arima H. Increased Risk of Thyroid Dysfunction by PD-1 and CTLA-4 Blockade in Patients Without Thyroid Autoantibodies at Baseline. J Clin Endocrinol Metab. 2022; 107(4): e1620-e1630.
    2. Iwama S, Kobayashi T, Yasuda Y, Arima H. Immune checkpoint inhibitor-related thyroid dysfunction. Best Pract Res Clin Endocrinol Metab. 2022; 36(3): 101660.
    3. Kobayashi T, Iwama S, Yamagami A, Yasuda Y, Okuji T, Ito M, Zhou X, Ando M, Onoue T, Miyata T, Sugiyama M, Hagiwara D, Suga H, Banno R, Hase T, Morise M, Ito T, Kikumori T, Inoue M, Ando Y, Masuda N, Kawashima H, Hashimoto N, Arima H. Elevated TSH Level, TgAb, and Prior Use of Ramucirumab or TKIs as Risk Factors for Thyroid Dysfunction in PD-L1 Blockade. J Clin Endocrinol Metab. 2022; 107(10): e4115-e4123
    4. Ozaki H, Suga H*, Sakakibara M, Soen M, Miyake N, Miwata T, Taga S, Nagai T, Kano M, Mitsumoto K, Miyata T, Kobayashi T, Sugiyama M, Onoue T, Takagi H, Hagiwara D, Iwama S, Banno R, Iguchi G, Takahashi Y, Muguruma K, Inoue H, Arima H. Differentiation of human induced pluripotent stem cells into hypothalamic vasopressin neurons with minimal exogenous signals and partial conversion to the naive state. Scientific Reports. 2022; 12: 17381
    5. Sun R, Sugiyama M, Wang S, Kuno M, Sasaki T, Hirose T, Miyata T, Kobayashi T, Tsunekawa T, Onoue T, Yasuda Y, Takagi H, Hagiwara D, Iwama S, Suga H, Arima H. Inflammation in VTA Caused by HFD Induces Activation of Dopaminergic Neurons Accompanied by Binge-like Eating. Nutrients 2022; 16: 3835
  • 2021年
    1. Iwama S, Kobayashi T, Arima H. Clinical Characteristics, Management, and Potential Biomarkers of Endocrine Dysfunction Induced by Immune Checkpoint Inhibitors. Endocrinol Metab (Seoul). 2021;36(2):312-321.
    2. Yasuda Y, Iwama S, Sugiyama D, Okuji T, Kobayashi T, Ito M, Okada N, Enomoto A, Ito S, Yan Y, Sugiyama M, Onoue T, Tsunekawa T, Ito Y, Takagi H, Hagiwara D, Goto M, Suga H, Banno R, Takahashi M, Nishikawa H, Arima H. CD4+ T cells are essential for the development of destructive thyroiditis induced by anti-PD-1 antibody in thyroglobulin-immunized mice. Sci Transl Med. 2021;13(593):eabb7495.
    3. Kobayashi T, Iwama S, Sugiyama D, Yasuda Y, Okuji T, Ito M, Ito S, Sugiyama M, Onoue T, Takagi H, Hagiwara D, Ito Y, Suga H, Banno R, Nishikawa H, Arima H. Anti-pituitary antibodies and susceptible human leukocyte antigen alleles as predictive biomarkers for pituitary dysfunction induced by immune checkpoint inhibitors. J Immunother Cancer. 2021;9(5):e002493
    4. Kawabata T, Suga H, Takeuchi K, Nagata Y, Sakakibara M, Ushida K, Ozone C, Enomoto A, Kawamoto I, Itagaki I, Tsuchiya H, Arima H, Wakabayashi T. A new primate model of hypophyseal dysfunction, Scientific Reports 2021;11(1):10729
    5. Yaginuma H, Banno R, Sun R, Taki K, Mizoguchi A, Kobayashi T, Sugiyama M, Tsunekawa T, Onoue T, Takagi H, Hagiwara D, Ito Y, Iwama S, Suga H, Arima H. Peripheral combination treatment of leptin and an SGLT2 inhibitor improved glucose metabolism in insulin-dependent diabetes mellitus mice. J Pharmacol Sci. 2021;147(4):340-347
    6. Mizoguchi A, Banno R, Sun R, Yaginuma H, Taki K, Kobayashi T, Sugiyama M, Tsunekawa T, Onoue T, Takagi H, Hagiwara D, Ito Y, Iwama S, Suga H, Nagai T, Yamada K, Arima H. Glucocorticoid receptor signaling in ventral tegmental area neurons increases the rewarding value of a high-fat diet in mice.Sci Rep. 2021;11(1):12873
    7. Sun R, Tsunekawa T, Hirose T, Yaginuma H, Taki K, Mizoguchi A, Miyata T, Kobayashi T, Sugiyama M, Onoue T, Takagi H, Hagiwara D, Ito Y, Iwama S, Suga H, Banno R, Bettler B, Arima H. GABAB receptor signaling in the caudate putamen is involved in binge-like consumption during a high fat diet in mice. Sci Rep. 2021;11(1):19296
    8. Wada E, Onoue T, Kinoshita T, Hayase A, Handa T, Ito M, Furukawa M, Okuji T, Kobayashi T, Iwama S, Sugiyama M, Takagi H, Hagiwara D, Suga H, Banno R, Goto M, Arima H. Adult-onset autoimmune diabetes identified by glutamic acid decarboxylase autoantibodies: a retrospective cohort study. Diabetologia. 2021;64(10):2183-2192
    9. Furukawa M, Onoue T, Kato K, Wada T, Shinohara Y, Kinoshita F, Goto M, Arima H, Tsushita K. Prediabetes is associated with proteinuria development but not with glomerular filtration rate decline: A longitudinal observational study. Diabet Med. 2021;38(8):e14607
    10. Mizoguchi A, Banno R, Sun R, Yaginuma H, Taki K, Kobayashi T, Sugiyama M, Tsunekawa T, Onoue T, Takagi H, Hagiwara D, Ito Y, Iwama S, Suga H, Arima H. High-fat Feeding Causes Inflammation and Insulin Resistance in the Ventral Tegmental Area in Mice. neuroscience. 2021; 461: 72-79.
    11. Ozaki H,. Suga H., Arima H. Hypothalamic-pituitary organoid generation through the recapitulation of organogenesis. Development, growth & differentiation. 2021; 63(2): 154-165.
    12. Hagiwara D, Tochiya M, Azuma Y, Tsumura T, Hodai Y, Kawaguchi Y, Miyata T, Kobayashi T, Sugiyama M, Onoue T, Takagi H, Ito Y, Iwama S, Suga H, Banno R, Arima H. Arginine vasopressin-Venus reporter mice as a tool for studying magnocellular arginine vasopressin neurons. Peptides. 2021; 139: 170517.
    13. Taki K, Takagi H, Hirose T, Sun R, Yaginuma H, Mizoguchi A, Kobayashi T, Sugiyama M, Tsunekawa T, Onoue T, Hagiwara D, Ito Y, Iwama S, Suga H, Banno R, Sakano D, Kume S, Arima H. Dietary sodium chloride attenuates increased β-cell mass to cause glucose intolerance in mice under a high-fat diet. PLoS One. 2021; 16(3): e0248065.
  • 2020年
    1. Sugiyama M, Banno R, Yaginuma H, Taki K, Mizoguchi A, Tsunekawa T, Onoue T, Takagi H, Ito Y, Iwama S, Goto M, Suga H, Komine O, Yamanaka K, Arima H. Hypothalamic glial cells isolated by MACS reveal that microglia and astrocytes induce hypothalamic inflammation via different processes under high-fat diet conditions. neurochemistry international. 2020;136:104733.
    2. Yoshida S, Okura H, Suga H, Nishitomi T, Sakurai A, Arima H, Matsuyama A. Generation of Three Induced Pluripotent Stem Cell (iPSC) Lines From a Multiple Endocrine Neoplasia Type 1 (MEN1) Patient and Three iPSC Lines From an Unaffected Relative of the Patient. Stem Cell Res. 2020;46:101846.
    3. Kobayashi T, Iwama S, Yasuda Y, Okada N, Okuji T, Ito M, Onoue T, Goto M, Sugiyama M, Tsunekawa T, Takagi H, Hagiwara D, Ito Y, Suga H, Banno R, Yokota K, Hase T, Morise M, Hashimoto N, Ando M, Fujimoto Y, Hibi H, Sone M, Ando Y, Akiyama M, Hasegawa Y, Arima H.Pituitary dysfunction induced by immune checkpoint inhibitors is associated with better overall survival in both malignant melanoma and non-small cell lung carcinoma: a prospective study. J Immunother Cancer. 2020;8(2):e000779.
    4. Yoshida S, Okura H, Suga H, Soen M, Kawaguchi Y, Kurimoto J, Miyata T, Takagi H, Arima H, Fujikawa T, Otsuka F, Matsuyama A. Generation of four induced pluripotent stem cell lines (FHUi003-A, FHUi003-B, FHUi004-A, and FHUi004-B) from two affected individuals of a familial neurophypophyseal diabetes insipidus family. Stem Cell Res. 2020;48:101960.
    5. Miyata T, Hagiwara D, Hodai Y, Miwata T, Kawaguchi Y, Kurimoto J, Ozaki H, Mitsumoto K, Takagi H, Suga H, Kobayashi T, Sugiyama M, Onoue T, Ito Y, Iwama S, Banno R, Matsumoto M, Kawakami N, Ohno N, Sakamoto H, Arima H. Degradation of mutant protein aggregates within the endoplasmic reticulum of vasopressin neurons. iScience. 2020;23(10);101648.
    6. Iwama S, Arima H. Anti-pituitary antibodies as a marker of autoimmunity in pituitary glands. Endocr J. 2020;67(11):1077-1083.
    7. Wada E, Onoue T, Kobayashi T, Handa T, Hayase A, Ito M, Furukawa M, Okuji T, Okada N, Iwama S, Sugiyama M, Tsunekawa T, Takagi H, Hagiwara D, Ito Y, Suga H, Banno R, Kuwatsuka Y, Ando M, Goto M, Arima H. Flash glucose monitoring helps achieve better glycemic control than conventional self-monitoring of blood glucose in non-insulin-treated type 2 diabetes: a randomized controlled trial. BMJ Open Diabetes Res Care. 2020;8(1):e001115.
    8. Kawaguchi Y, Hagiwara D, Miyata T, Hodai Y, Kurimoto J, Takagi H, Suga H, Kobayashi T, Sugiyama M, Onoue T, Ito Y, Iwama S, Banno R, Grinevich V, Arima H.Endoplasmic reticulum chaperone BiP/GRP78 knockdown leads to autophagy and cell death of arginine vasopressin neurons in mice. Sci Rep. 2020;10(1):19730.
    9. Okada N, Iwama S, Okuji T, Kobayashi T, Yasuda Y, Wada E, Onoue T, Goto M, Sugiyama M, Tsunekawa T, Takagi H, Hagiwara D, Ito Y, Suga H, Banno R, Hase T, Morise M, Kanda M, Yokota K, Hashimoto N, Ando M, Fujimoto Y, Nagino M, Kodera Y, Fujishiro M, Hibi H, Sone M, Kiyoi H, Gotoh M, Ando Y, Akiyama M, Hasegawa Y, Arima H. Anti-thyroid antibodies and thyroid echo pattern at baseline as risk factors for thyroid dysfunction induced by anti-programmed cell death-1 antibodies: a prospective study. Br J Cancer. 2020; 122(6): 771-777.
  • 2019年
    1. Yasuda Y, Iwama S, Arima H. Severe hypocalcemia following denosumab treatment in a patient with secondary osteoporosis associated with primary sclerosing cholangitis. Endocrine journal. 2019;66(3):271-275.
    2. Suga H. Application of pluripotent stem cells for treatment of human neuroendocrine disorders. Cell and tissue research. 2019;375(1):267-278.
    3. Murase M, Seino Y, Maekawa R, et al. Functional adenosine triphosphate-sensitive potassium channel is required in high-carbohydrate diet-induced increase in beta-cell mass. Journal of diabetes investigation. 2019;10(2):238-250.
    4. Kobayashi T, Tsushita K, Nomura E, et al. Automated Feedback Messages With Shichifukujin Characters Using IoT System-Improved Glycemic Control in People With Diabetes: A Prospective, Multicenter Randomized Controlled Trial. Journal of diabetes science and technology. 2019;13(4):796-798.
    5. Hagiwara D, Grinevich V, Arima H. A novel mechanism of autophagy-associated cell death of vasopressin neurons in familial neurohypophysial diabetes insipidus. Cell and tissue research. 2019;375(1):259-266.
    6. Arima H, Iwama S, Inaba H, et al. Management of immune-related adverse events in endocrine organs induced by immune checkpoint inhibitors: clinical guidelines of the Japan Endocrine Society. Endocrine journal. 2019;66(7):581-586.
    7. Kano M, Suga H, Ishihara T, et al. Tanycyte-Like Cells Derived From Mouse Embryonic Stem Culture Show Hypothalamic Neural Stem/Progenitor Cell Functions. Endocrinology. 2019;160(7):1701-1718.
    8. Kawaguchi Y, Shimauchi R, Nishibori N, et al. Dipeptidyl peptidase-4 inhibitors-associated bullous pemphigoid: A retrospective study of 168 pemphigoid and 9,304 diabetes mellitus patients. Journal of diabetes investigation. 2019;10(2):392-398.
  • 2018年
    1. Kano M, Suga H, Kasai T, Ozone C, Arima H: Functional Pituitary Tissue Generation from Human Embryonic Stem Cells. Curr Protoc Neurosci 2018, 83:e48.
    2. Kimbara S, Fujiwara Y, Iwama S, Ohashi K, Kuchiba A, Arima H, Yamazaki N, Kitano S, Yamamoto N, Ohe Y: Association of antithyroglobulin antibodies with the development of thyroid dysfunction induced by nivolumab. Cancer Sci 2018, 109:3583-3590.
    3. Kobayashi T, Iwama S, Yasuda Y, Okada N, Tsunekawa T, Onoue T, Takagi H, Hagiwara D, Ito Y, Morishita Y, et al: Patients With Antithyroid Antibodies Are Prone To Develop Destructive Thyroiditis by Nivolumab: A Prospective Study. J Endocr Soc 2018, 2:241-251.
    4. Maekawa R, Ogata H, Murase M, Harada N, Suzuki K, Joo E, Sankoda A, Iida A, Izumoto T, Tsunekawa S, et al: Glucose-dependent insulinotropic polypeptide is required for moderate high-fat diet- but not high-carbohydrate diet-induced weight gain. Am J Physiol Endocrinol Metab 2018, 314:E572-e583.
    5. Nakashima K, Takeuchi S, Iwama S, Kiyota A, Yasuda Y, Iwata N, Enomoto A, Arima H, Sugimura Y: Cullin-associated NEDD8-dissociated protein 1, a novel interactor of rabphilin-3A, deubiquitylates rabphilin-3A and regulates arginine vasopressin secretion in PC12 cells. Endocr J 2018, 65:325-334.
    6. Ogawa K, Suga H, Ozone C, Sakakibara M, Yamada T, Kano M, Mitsumoto K, Kasai T, Kodani Y, Nagasaki H, et al: Vasopressin-secreting neurons derived from human embryonic stem cells through specific induction of dorsal hypothalamic progenitors. Sci Rep 2018, 8:3615.
    7. Tochiya M, Hagiwara D, Azuma Y, Miyata T, Morishita Y, Suga H, Onoue T, Tsunekawa T, Takagi H, Ito Y, et al: Chemical chaperone 4-phenylbutylate reduces mutant protein accumulation in the endoplasmic reticulum of arginine vasopressin neurons in a mouse model for familial neurohypophysial diabetes insipidus. Neurosci Lett 2018, 682:50-55.
    8. Yasuda Y, Iwama S, Kiyota A, Izumida H, Nakashima K, Iwata N, Ito Y, Morishita Y, Goto M, Suga H, et al: Critical role of rabphilin-3A in the pathophysiology of experimental lymphocytic neurohypophysitis. J Pathol 2018, 244:469-478.
    9. Siriguleng S, Koike T, Natsume Y, Iwama S, Oshida Y: Effect of prior chronic aerobic exercise on overload-induced skeletal muscle hypertrophy in mice. Physiol Res 2018, 67:765-775.
  • 2017年
    1. Hosokawa K, Hamada Y, Fujiya A, Murase M, Maekawa R, Niwa Y, Izumoto T, Seino Y, Tsunekawa S, Arima H: S100B impairs glycolysis via enhanced poly(ADP-ribosyl)ation of glyceraldehyde-3-phosphate dehydrogenase in rodent muscle cells. Am J Physiol Endocrinol Metab 2017, 312:E471-e481.
    2. Iwata N, Iwama S, Sugimura Y, Yasuda Y, Nakashima K, Takeuchi S, Hagiwara D, Ito Y, Suga H, Goto M, et al: Anti-pituitary antibodies against corticotrophs in IgG4-related hypophysitis. Pituitary 2017, 20:301-310.
    3. Maekawa R, Seino Y, Ogata H, Murase M, Iida A, Hosokawa K, Joo E, Harada N, Tsunekawa S, Hamada Y, et al: Chronic high-sucrose diet increases fibroblast growth factor 21 production and energy expenditure in mice. J Nutr Biochem 2017, 49:71-79.
    4. Muraoka Y, Iwama S, Arima H: Normalization of Bilateral Adrenal Gland Enlargement after Treatment for Cryptococcosis. Case Rep Endocrinol 2017, 2017:1543149.
    5. Onoue T, Goto M, Kobayashi T, Tominaga T, Ando M, Honda H, Yoshida Y, Tosaki T, Yokoi H, Kato S, et al: Randomized controlled trial for assessment of Internet of Things system to guide intensive glucose control in diabetes outpatients: Nagoya Health Navigator Study protocol. Nagoya J Med Sci 2017, 79:323-329.
    6. Sugiyama M, Banno R, Mizoguchi A, Tominaga T, Tsunekawa T, Onoue T, Hagiwara D, Ito Y, Morishita Y, Iwama S, et al: PTP1B deficiency improves hypothalamic insulin sensitivity resulting in the attenuation of AgRP mRNA expression under high-fat diet conditions. Biochem Biophys Res Commun 2017, 488:116-121.
    7. Tominaga T, Goto M, Onoue T, Mizoguchi A, Sugiyama M, Tsunekawa T, Hagiwara D, Morishita Y, Ito Y, Iwama S, et al: Sequestosome 1 (SQSTM1/p62) maintains protein folding capacity under endoplasmic reticulum stress in mouse hypothalamic organotypic culture. Neurosci Lett 2017, 656:103-107.
    8. Tsunekawa T, Banno R, Mizoguchi A, Sugiyama M, Tominaga T, Onoue T, Hagiwara D, Ito Y, Iwama S, Goto M, et al: Deficiency of PTP1B Attenuates Hypothalamic Inflammation via Activation of the JAK2-STAT3 Pathway in Microglia. EBioMedicine 2017, 16:172-183.
    9. Ozone C, Suga H: Functional Pituitary Tissue Formation. Methods Mol Biol 2017, 1597:57-65.
  • 2016年
    1. Fujisawa H, Sugimura Y, Takagi H, Mizoguchi H, Takeuchi H, Izumida H, Nakashima K, Ochiai H, Takeuchi S, Kiyota A, Fukumoto K, Iwama S, Takagishi Y, Hayashi Y, Arima H, Komatsu Y, Murata Y, Oiso Y. Chronic Hyponatremia Causes Neurologic and Psychologic Impairments. J Am Soc Nephrol, 2016; 27: 766-780.
    2. Iida A, Seino Y, Fukami A, Maekawa R, Yabe D, Shimizu S, Kinoshita K, Takagi Y, Izumoto T, Ogata H, Ishikawa K, Ozaki N, Tsunekawa S, Hamada Y, Oiso Y, Arima H, Hayashi Y. Endogenous GIP ameliorates impairment of insulin secretion in proglucagon-deficient mice under moderate beta cell damage induced by streptozotocin. Diabetologia, 2016; 59: 1533-1541.
    3. Izumida H, Takagi H, Fujisawa H, Iwata N, Nakashima K, Takeuchi S, Iwama S, Namba T, Komatu Y, Kaibuchi K, Oiso Y, Arima H, Sugimura Y. NMDA receptor antagonist prevents cell death in the hippocampal dentate gyrus induced by hyponatremia accompanying adrenal insufficiency in rats. Exp Neurol, 2016.
    4. Lu W, Hagiwara D, Morishita Y, Tochiya M, Azuma Y, Suga H, Goto M, Banno R, Sugimura Y, Oyadomari S, Mori K, Arima H. Unfolded protein response in hypothalamic cultures of wild-type and ATF6alpha-knockout mice. Neurosci Lett, 2016; 612: 199-203.
    5. Onoue T, Goto M, Tominaga T, Sugiyama M, Tsunekawa T, Hagiwara D, Banno R, Suga H, Sugimura Y, Arima H. Reactive oxygen species mediate insulin signal transduction in mouse hypothalamus. Neurosci Lett, 2016; 619: 1-7.
    6. Shibata M, Banno R, Sugiyama M, Tominaga T, Onoue T, Tsunekawa T, Azuma Y, Hagiwara D, Lu W, Ito Y, Goto M, Suga H, Sugimura Y, Oiso Y, Arima H. AgRP Neuron-Specific Deletion of Glucocorticoid Receptor Leads to Increased Energy Expenditure and Decreased Body Weight in Female Mice on a High-Fat Diet. Endocrinology, 2016; 157: 1457-1466.
    7. Takeuchi S, Iwama S, Takagi H, Kiyota A, Nakashima K, Izumida H, Fujisawa H, Iwata N, Suga H, Watanabe T, Kaibuchi K, Oiso Y, Arima H, Sugimura Y. Tomosyn Negatively Regulates Arginine Vasopressin Secretion in Embryonic Stem Cell-Derived Neurons. PLoS One, 2016; 11: e0164544.
    8. Ozone C, Suga H, Eiraku M, Kadoshima T, Yonemura S, Takata N, Oiso Y, Tsuji T, Sasai Y. Functional anterior pituitary generated in self-organizing culture of human embryonic stem cells. Nat Commun, 2016; 7: 10351.
    9. Seino Y, Maekawa R, Ogata H, Hayashi Y. Carbohydrate-induced secretion of glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1. J Diabetes Investig, 2016; 7 Suppl 1: 27-32.
    10. Ji S, Tokizane K, Ohkawa Y, Ohmi Y, Banno R, Okajima T, Kiyama H, Furukawa K, Furukawa K. Increased a-series gangliosides positively regulate leptin/Ob receptor-mediated signals in hypothalamus of GD3 synthase-deficient mice. Biochem Biophys Res Commun, 2016; 479: 453-460.
  • 2015年
    1. Iwama S, Sugimura Y, Kiyota A, Kato T, Enomoto A, Suzuki H, Iwata N, Takeuchi S, Nakashima K, Takagi H, Izumida H, Ochiai H, Fujisawa H, Suga H, Arima H, Shimoyama Y, Takahashi M, Nishioka H, Ishikawa SE, Shimatsu A, Caturegli P, Oiso Y. Rabphilin-3A as a Targeted Autoantigen in Lymphocytic Infundibulo-neurohypophysitis. J Clin Endocrinol Metab, 2015; 100: E946-954.
    2. Izumoto-Akita T, Tsunekawa S, Yamamoto A, Uenishi E, Ishikawa K, Ogata H, Iida A, Ikeniwa M, Hosokawa K, Niwa Y, Maekawa R, Yamauchi Y, Seino Y, Hamada Y, Hibi H, Arima H, Ueda M, Oiso Y. Secreted factors from dental pulp stem cells improve glucose intolerance in streptozotocin-induced diabetic mice by increasing pancreatic beta-cell function. BMJ Open Diabetes Res Care, 2015; 3: e000128.
    3. Kataoka Y, Nishida S, Hirakawa A, Oiso Y, Arima H. Comparison of incidence of hyponatremia between intranasal and oral desmopressin in patients with central diabetes insipidus. Endocr J, 2015; 62: 195-200.
    4. Kiyota A, Iwama S, Sugimura Y, Takeuchi S, Takagi H, Iwata N, Nakashima K, Suzuki H, Nishioka T, Kato T, Enomoto A, Arima H, Kaibuchi K, Oiso Y. Identification of the novel autoantigen candidate Rab GDP dissociation inhibitor alpha in isolated adrenocorticotropin deficiency. Endocr J, 2015; 62: 153-160.
    5. Niwa Y, Ishikawa K, Ishigami M, Honda T, Achiwa K, Izumoto T, Maekawa R, Hosokawa K, Iida A, Seino Y, Hamada Y, Goto H, Oiso Y, Arima H, Tsunekawa S. Effect of hyperglycemia on hepatocellular carcinoma development in diabetes. Biochem Biophys Res Commun, 2015; 463: 344-350.
    6. Ochiai H, Suga H, Yamada T, Sakakibara M, Kasai T, Ozone C, Ogawa K, Goto M, Banno R, Tsunekawa S, Sugimura Y, Arima H, Oiso Y. BMP4 and FGF strongly induce differentiation of mouse ES cells into oral ectoderm. Stem Cell Res, 2015; 15: 290-298.
    7. Takahashi A, Lee RX, Iwasato T, Itohara S, Arima H, Bettler B, Miczek KA, Koide T. Glutamate input in the dorsal raphe nucleus as a determinant of escalated aggression in male mice. J Neurosci, 2015; 35: 6452-6463.
    8. Ishikawa K, Tsunekawa S, Ikeniwa M, Izumoto T, Iida A, Ogata H, Uenishi E, Seino Y, Ozaki N, Sugimura Y, Hamada Y, Kuroda A, Shinjo K, Kondo Y, Oiso Y. Long-term pancreatic beta cell exposure to high levels of glucose but not palmitate induces DNA methylation within the insulin gene promoter and represses transcriptional activity. PLoS One, 2015; 10: e0115350.
    9. Seino Y, Ogata H, Maekawa R, Izumoto T, Iida A, Harada N, Miki T, Seino S, Inagaki N, Tsunekawa S, Oiso Y, Hamada Y. Fructose induces glucose-dependent insulinotropic polypeptide, glucagon-like peptide-1 and insulin secretion: Role of adenosine triphosphate-sensitive K(+) channels. J Diabetes Investig, 2015; 6: 522-526.
    10. Ji S, Ohkawa Y, Tokizane K, Ohmi Y, Banno R, Furukawa K, Kiyama H, Furukawa K. b-Series gangliosides crucially regulate leptin secretion in adipose tissues. Biochem Biophys Res Commun, 2015; 459: 189-195.
  • 2014年
    1. Adachi K, Goto M, Onoue T, Tsunekawa T, Shibata M, Hagimoto S, Ito Y, Banno R, Suga H, Sugimura Y, Oiso Y, Arima H. Mitogen-activated protein kinase phosphatase 1 negatively regulates MAPK signaling in mouse hypothalamus. Neurosci Lett, 2014; 569: 49-54.
    2. Arima H, Morishita Y, Hagiwara D, Hayashi M, Oiso Y. Endoplasmic reticulum stress in vasopressin neurons of familial diabetes insipidus model mice: aggregate formation and mRNA poly(A) tail shortening. Exp Physiol, 2014; 99: 66-71.
    3. Arima H, Wakabayashi T, Nagatani T, Fujii M, Hirakawa A, Murase T, Yambe Y, Yamada T, Yamakawa F, Yamamori I, Yamauchi M, Oiso Y. Adipsia increases risk of death in patients with central diabetes insipidus. Endocr J, 2014; 61: 143-148.
    4. Azuma Y, Hagiwara D, Lu W, Morishita Y, Suga H, Goto M, Banno R, Sugimura Y, Oyadomari S, Mori K, Shiota A, Asai N, Takahashi M, Oiso Y, Arima H. Activating transcription factor 6alpha is required for the vasopressin neuron system to maintain water balance under dehydration in male mice. Endocrinology, 2014; 155: 4905-4914.
    5. Hagiwara D, Arima H, Morishita Y, Wenjun L, Azuma Y, Ito Y, Suga H, Goto M, Banno R, Sugimura Y, Shiota A, Asai N, Takahashi M, Oiso Y. Arginine vasopressin neuronal loss results from autophagy-associated cell death in a mouse model for familial neurohypophysial diabetes insipidus. Cell Death Dis, 2014; 5: e1148.
    6. Takagi H, Sugimura Y, Suzuki H, Iwama S, Izumida H, Fujisawa H, Ogawa K, Nakashima K, Ochiai H, Takeuchi S, Kiyota A, Suga H, Goto M, Banno R, Arima H, Oiso Y. Minocycline prevents osmotic demyelination associated with aquaresis. Kidney Int, 2014; 86: 954-964.
    7. Kato J, Kamiya H, Himeno T, Shibata T, Kondo M, Okawa T, Fujiya A, Fukami A, Uenishi E, Seino Y, Tsunekawa S, Hamada Y, Naruse K, Oiso Y, Nakamura J. Mesenchymal stem cells ameliorate impaired wound healing through enhancing keratinocyte functions in diabetic foot ulcerations on the plantar skin of rats. J Diabetes Complications, 2014; 28: 588-595.
    8. Okawa T, Kamiya H, Himeno T, Seino Y, Tsunekawa S, Hayashi Y, Harada N, Yamada Y, Inagaki N, Seino Y, Oiso Y, Nakamura J. Sensory and motor physiological functions are impaired in gastric inhibitory polypeptide receptor-deficient mice. J Diabetes Investig, 2014; 5: 31-37.
    9. Fujiya A, Nagasaki H, Seino Y, Okawa T, Kato J, Fukami A, Himeno T, Uenishi E, Tsunekawa S, Kamiya H, Nakamura J, Oiso Y, Hamada Y. The role of S100B in the interaction between adipocytes and macrophages. Obesity (Silver Spring), 2014; 22: 371-379.
    10. Ogata H, Seino Y, Harada N, Iida A, Suzuki K, Izumoto T, Ishikawa K, Uenishi E, Ozaki N, Hayashi Y, Miki T, Inagaki N, Tsunekawa S, Hamada Y, Seino S, Oiso Y. KATP channel as well as SGLT1 participates in GIP secretion in the diabetic state. J Endocrinol, 2014; 222: 191-200.
  • 2013年
    1. Arima H, Oiso Y, Juul KV, Norgaard JP. Efficacy and safety of desmopressin orally disintegrating tablet in patients with central diabetes insipidus: results of a multicenter open-label dose-titration study. Endocr J, 2013; 60: 1085-1094.
    2. Hagimoto S, Arima H, Adachi K, Ito Y, Suga H, Sugimura Y, Goto M, Banno R, Oiso Y. Expression of neuropeptide Y and agouti-related protein mRNA stimulated by glucocorticoids is attenuated via NF-kappaB p65 under ER stress in mouse hypothalamic cultures. Neurosci Lett, 2013; 553: 165-169.
    3. Ito Y, Banno R, Shibata M, Adachi K, Hagimoto S, Hagiwara D, Ozawa Y, Goto M, Suga H, Sugimura Y, Bettler B, Oiso Y, Arima H. GABA type B receptor signaling in proopiomelanocortin neurons protects against obesity, insulin resistance, and hypothalamic inflammation in male mice on a high-fat diet. J Neurosci, 2013; 33: 17166-17173.
    4. Hamada Y, Nagasaki H, Fuchigami M, Furuta S, Seino Y, Nakamura J, Oiso Y. The alpha-glucosidase inhibitor miglitol affects bile acid metabolism and ameliorates obesity and insulin resistance in diabetic mice. Metabolism, 2013; 62: 734-742.
    5. Okawa T, Kamiya H, Himeno T, Kato J, Seino Y, Fujiya A, Kondo M, Tsunekawa S, Naruse K, Hamada Y, Ozaki N, Cheng Z, Kito T, Suzuki H, Ito S, Oiso Y, Nakamura J, Isobe K. Transplantation of neural crest-like cells derived from induced pluripotent stem cells improves diabetic polyneuropathy in mice. Cell Transplant, 2013; 22: 1767-1783.
    6. Fukami A, Seino Y, Ozaki N, Yamamoto M, Sugiyama C, Sakamoto-Miura E, Himeno T, Takagishi Y, Tsunekawa S, Ali S, Drucker DJ, Murata Y, Seino Y, Oiso Y, Hayashi Y. Ectopic expression of GIP in pancreatic beta-cells maintains enhanced insulin secretion in mice with complete absence of proglucagon-derived peptides. Diabetes, 2013; 62: 510-518.
    7. Okawa T, Tsunekawa S, Seino Y, Hamada Y, Oiso Y. Deceptive HbA(1)c in a patient with pure red cell aplasia. Lancet, 2013; 382: 366.
    8. Hayashi M, Kataoka Y, Sugimura Y, Kato F, Fukami M, Ogata T, Homma K, Hasegawa T, Oiso Y, Sasano H, Tanaka H. A 68-year-old phenotypically male patient with 21-hydroxylase deficiency and concomitant adrenocortical neoplasm producing testosterone and cortisol. Tohoku J Exp Med, 2013; 231: 75-84.
  • 2012年
    1. Hagiwara D, Arima H, Morishita Y, Goto M, Banno R, Sugimura Y, Oiso Y. BiP mRNA expression is upregulated by dehydration in vasopressin neurons in the hypothalamus in mice. Peptides, 2012; 33: 346-350.
    2. Ito Y, Banno R, Hagimoto S, Ozawa Y, Arima H, Oiso Y. TNFalpha increases hypothalamic PTP1B activity via the NFkappaB pathway in rat hypothalamic organotypic cultures. Regul Pept, 2012; 174: 58-64.
    3. Mizutani N, Ozaki N, Seino Y, Fukami A, Sakamoto E, Fukuyama T, Sugimura Y, Nagasaki H, Arima H, Oiso Y. Reduction of insulin signaling upregulates angiopoietin-like protein 4 through elevated free fatty acids in diabetic mice. Exp Clin Endocrinol Diabetes, 2012; 120: 139-144.
    4. Nagasaki H, Kondo T, Fuchigami M, Hashimoto H, Sugimura Y, Ozaki N, Arima H, Ota A, Oiso Y, Hamada Y. Inflammatory changes in adipose tissue enhance expression of GPR84, a medium-chain fatty acid receptor: TNFalpha enhances GPR84 expression in adipocytes. FEBS Lett, 2012; 586: 368-372.
    5. Ozawa Y, Arima H, Banno R, Ito Y, Goto M, Morishita Y, Sugimura Y, Ozaki N, Nagasaki H, Oiso Y. Lesion of area postrema attenuated hyperphagic responses to glucoprivation, but not transcriptional activation of the neuropeptide Y gene in rats. Neuroreport, 2012; 23: 673-675.
    6. Sakamoto E, Seino Y, Fukami A, Mizutani N, Tsunekawa S, Ishikawa K, Ogata H, Uenishi E, Kamiya H, Hamada Y, Sato H, Harada N, Toyoda Y, Miwa I, Nakamura J, Inagaki N, Oiso Y, Ozaki N. Ingestion of a moderate high-sucrose diet results in glucose intolerance with reduced liver glucokinase activity and impaired glucagon-like peptide-1 secretion. J Diabetes Investig, 2012; 3: 432-440.
    7. Watanabe C, Seino Y, Miyahira H, Yamamoto M, Fukami A, Ozaki N, Takagishi Y, Sato J, Fukuwatari T, Shibata K, Oiso Y, Murata Y, Hayashi Y. Remodeling of hepatic metabolism and hyperaminoacidemia in mice deficient in proglucagon-derived peptides. Diabetes, 2012; 61: 74-84.
  • 2011年
    1. Iwama S, Sugimura Y, Suzuki H, Suzuki H, Murase T, Ozaki N, Nagasaki H, Arima H, Murata Y, Sawada M, Oiso Y. Time-dependent changes in proinflammatory and neurotrophic responses of microglia and astrocytes in a rat model of osmotic demyelination syndrome. Glia, 2011; 59: 452-462.
    2. Morishita Y, Arima H, Hiroi M, Hayashi M, Hagiwara D, Asai N, Ozaki N, Sugimura Y, Nagasaki H, Shiota A, Takahashi M, Oiso Y. Poly(A) tail length of neurohypophysial hormones is shortened under endoplasmic reticulum stress. Endocrinology, 2011; 152: 4846-4855.
    3. Ozawa Y, Arima H, Watanabe M, Shimizu H, Ito Y, Banno R, Sugimura Y, Ozaki N, Nagasaki H, Oiso Y. Repeated glucoprivation delayed hyperphagic responses while activating neuropeptide Y neurons in rats. Peptides, 2011; 32: 763-769.
    4. Himeno T, Kamiya H, Naruse K, Harada N, Ozaki N, Seino Y, Shibata T, Kondo M, Kato J, Okawa T, Fukami A, Hamada Y, Inagaki N, Seino Y, Drucker DJ, Oiso Y, Nakamura J. Beneficial effects of exendin-4 on experimental polyneuropathy in diabetic mice. Diabetes, 2011; 60: 2397-2406.
  • 2010年
    1. Arima H, Oiso Y. Positive effect of baclofen on body weight reduction in obese subjects: a pilot study. Intern Med, 2010; 49: 2043-2047.
    2. Arima H, Oiso Y. Mechanisms underlying progressive polyuria in familial neurohypophysial diabetes insipidus. J Neuroendocrinol, 2010; 22: 754-757.
    3. Hiroi M, Morishita Y, Hayashi M, Ozaki N, Sugimura Y, Nagasaki H, Shiota A, Oiso Y, Arima H. Activation of vasopressin neurons leads to phenotype progression in a mouse model for familial neurohypophysial diabetes insipidus. Am J Physiol Regul Integr Comp Physiol, 2010; 298: R486-493.
    4. Kawada K, Kitagawa K, Kamei S, Inada M, Mitsuma A, Sawaki M, Kikumori T, Fujimoto Y, Arima H, Imai T, Ando Y. The feasibility study of docetaxel in patients with anaplastic thyroid cancer. Jpn J Clin Oncol, 2010; 40: 596-599.
    5. Shimizu H, Arima H, Ozawa Y, Watanabe M, Banno R, Sugimura Y, Ozaki N, Nagasaki H, Oiso Y. Glucocorticoids increase NPY gene expression in the arcuate nucleus by inhibiting mTOR signaling in rat hypothalamic organotypic cultures. Peptides, 2010; 31: 145-149.
    6. Suzuki H, Sugimura Y, Iwama S, Suzuki H, Nobuaki O, Nagasaki H, Arima H, Sawada M, Oiso Y. Minocycline prevents osmotic demyelination syndrome by inhibiting the activation of microglia. J Am Soc Nephrol, 2010; 21: 2090-2098.
    7. Umeda H, Ozaki N, Mizutani N, Fukuyama T, Nagasaki H, Arima H, Oiso Y. Protective effect of hedgehog signaling on cytokine-induced cytotoxicity in pancreatic beta-cells. Exp Clin Endocrinol Diabetes, 2010; 118: 692-698.
    8. Yokota F, Arima H, Hirano M, Uchikawa T, Inden Y, Nagatani T, Oiso Y. Normalisation of plasma growth hormone levels improved cardiac dysfunction due to acromegalic cardiomyopathy with severe fibrosis. BMJ Case Rep, 2010; 2010.
  • 2009年
    1. Arima H, Imamine R, Oiso Y. Ping-pong champion with adrenal insufficiency. BMJ Case Rep, 2009; 2009.
    2. Hayashi M, Arima H, Ozaki N, Morishita Y, Hiroi M, Ozaki N, Nagasaki H, Kinoshita N, Ueda M, Shiota A, Oiso Y. Progressive polyuria without vasopressin neuron loss in a mouse model for familial neurohypophysial diabetes insipidus. Am J Physiol Regul Integr Comp Physiol, 2009; 296: R1641-1649.
    3. Imamine R, Arima H, Kusakabe M, Umeda H, Sato I, Homma K, Usui T, Oiso Y. Genetic analysis of two Japanese patients with non-classical 21-hydroxylase deficiency. Intern Med, 2009; 48: 705-709.
    4. Iwama S, Sugimura Y, Murase T, Hiroi M, Goto M, Hayashi M, Arima H, Oiso Y. Central adiponectin functions to inhibit arginine vasopressin release in conscious rats. J Neuroendocrinol, 2009; 21: 753-759.
    5. Suzuki C, Nagasaki H, Okajima Y, Suga H, Ozaki N, Arima H, Iwasaki Y, Oiso Y. Inflammatory cytokines regulate glycoprotein subunit beta5 of thyrostimulin through nuclear factor-kappaB. Endocrinology, 2009; 150: 2237-2243.
    6. Watanabe M, Arima H, Ozawa Y, Goto M, Shimizu H, Banno R, Sugimura Y, Ozaki N, Nagasaki H, Oiso Y. The medial hypothalamus is required for the feeding response to glucoprivation but not to food deprivation. Neurosci Lett, 2009; 464: 6-9.
    7. Oyama K, Sugimura Y, Murase T, Uchida A, Hayasaka S, Oiso Y, Murata Y. Folic acid prevents congenital malformations in the offspring of diabetic mice. Endocr J, 2009; 56: 29-37.
    8. Sugimura Y, Murase T, Kobayashi K, Oyama K, Hayasaka S, Kanou Y, Oiso Y, Murata Y. Alpha-lipoic acid reduces congenital malformations in the offspring of diabetic mice. Diabetes Metab Res Rev, 2009; 25: 287-294.
    9. Sugimura Y, Murase T, Oyama K, Uchida A, Sato N, Hayasaka S, Kano Y, Takagishi Y, Hayashi Y, Oiso Y, Murata Y. Prevention of neural tube defects by loss of function of inducible nitric oxide synthase in fetuses of a mouse model of streptozotocin-induced diabetes. Diabetologia, 2009; 52: 962-971.
  • 2008年
    1. Okajima Y, Nagasaki H, Suzuki C, Suga H, Ozaki N, Arima H, Hamada Y, Civelli O, Oiso Y. Biochemical roles of the oligosaccharide chains in thyrostimulin, a heterodimeric hormone of glycoprotein hormone subunits alpha 2 (GPA2) and beta 5 (GPB5). Regul Pept, 2008; 148: 62-67.
    2. Shimizu H, Arima H, Watanabe M, Goto M, Banno R, Sato I, Ozaki N, Nagasaki H, Oiso Y. Glucocorticoids increase neuropeptide Y and agouti-related peptide gene expression via adenosine monophosphate-activated protein kinase signaling in the arcuate nucleus of rats. Endocrinology, 2008; 149: 4544-4553.
    3. Suga H, Nagasaki H, Kondo TA, Okajima Y, Suzuki C, Ozaki N, Arima H, Yamamoto T, Ozaki N, Akai M, Sato A, Uozumi N, Inoue M, Hasegawa M, Oiso Y. Novel treatment for lithium-induced nephrogenic diabetes insipidus rat model using the Sendai-virus vector carrying aquaporin 2 gene. Endocrinology, 2008; 149: 5803-5810.
    4. Watanabe M, Arima H, Fukushima K, Goto M, Shimizu H, Hayashi M, Banno R, Sato I, Ozaki N, Nagasaki H, Oiso Y. Direct and indirect modulation of neuropeptide Y gene expression in response to hypoglycemia in rat arcuate nucleus. FEBS Lett, 2008; 582: 3632-3638.
  • 2007年
    1. Banno R, Arima H, Hayashi M, Goto M, Watanabe M, Sato I, Ozaki N, Nagasaki H, Ozaki N, Oiso Y. Central administration of melanocortin agonist increased insulin sensitivity in diet-induced obese rats. FEBS Lett, 2007; 581: 1131-1136.
    2. Goto M, Arima H, Hiroi M, Shimizu H, Watanabe M, Hayashi M, Banno R, Sato I, Ozaki N, Nagasaki H, Oiso Y. Insulin is not a prerequisite for rapid regulation of neuropeptide Y gene transcription in the arcuate nucleus in food-restricted rats. Neurosci Lett, 2007; 420: 61-65.
    3. Sato I, Arima H, Ozaki N, Ozaki N, Watanabe M, Goto M, Shimizu H, Hayashi M, Banno R, Nagasaki H, Oiso Y. Peripherally administered baclofen reduced food intake and body weight in db/db as well as diet-induced obese mice. FEBS Lett, 2007; 581: 4857-4864.
    4. Suzuki C, Nagasaki H, Okajima Y, Suga H, Arima H, Iwasaki Y, Oiso Y. The LIM domain homeobox gene isl-1 is a positive regulator of glycoprotein alpha 2 (GPA2), a subunit of thyrostimulin. Regul Pept, 2007; 142: 60-67.
    5. Takefuji S, Murase T, Sugimura Y, Takagishi Y, Hayasaka S, Oiso Y, Murata Y. Role of microglia in the pathogenesis of osmotic-induced demyelination. Exp Neurol, 2007; 204: 88-94.
  • 2006年
    1. Goto M, Arima H, Watanabe M, Hayashi M, Banno R, Sato I, Nagasaki H, Oiso Y. Ghrelin increases neuropeptide Y and agouti-related peptide gene expression in the arcuate nucleus in rat hypothalamic organotypic cultures. Endocrinology, 2006; 147: 5102-5109.
    2. Hayashi M, Arima H, Goto M, Banno R, Watanabe M, Sato I, Nagasaki H, Oiso Y. Vasopressin gene transcription increases in response to decreases in plasma volume, but not to increases in plasma osmolality, in chronically dehydrated rats. Am J Physiol Endocrinol Metab, 2006; 290: E213-217.
    3. Murase T, Sugimura Y, Takefuji S, Oiso Y, Murata Y. Mechanisms and therapy of osmotic demyelination. Am J Med, 2006; 119: S69-73.
  • 2005年
    1. Sato I, Arima H, Ozaki N, Watanabe M, Goto M, Hayashi M, Banno R, Nagasaki H, Oiso Y. Insulin inhibits neuropeptide Y gene expression in the arcuate nucleus through GABAergic systems. J Neurosci, 2005; 25: 8657-8664.
    2. Sugimura Y, Murase T, Takefuji S, Hayasaka S, Takagishi Y, Oiso Y, Murata Y. Protective effect of dexamethasone on osmotic-induced demyelination in rats. Exp Neurol, 2005; 192: 178-183.
  • 2004年
    1. Banno R, Arima H, Sato I, Hayashi M, Goto M, Sugimura Y, Murase T, Oiso Y. The melanocortin agonist melanotan II increases insulin sensitivity in OLETF rats. Peptides, 2004; 25: 1279-1286.
    2. Ishizaki S, Murase T, Sugimura Y, Banno R, Arima H, Miura Y, Oiso Y. Leukemia inhibitory factor stimulates vasopressin release in rats. Neurosci Lett, 2004; 359: 77-80.
    3. Kondo N, Arima H, Banno R, Kuwahara S, Sato I, Oiso Y. Osmoregulation of vasopressin release and gene transcription under acute and chronic hypovolemia in rats. Am J Physiol Endocrinol Metab, 2004; 286: E337-346.
  • 2003年
    1. Kuwahara S, Arima H, Banno R, Sato I, Kondo N, Oiso Y. Regulation of vasopressin gene expression by cAMP and glucocorticoids in parvocellular neurons of the paraventricular nucleus in rat hypothalamic organotypic cultures. J Neurosci, 2003; 23: 10231-10237.
    2. Sugimura Y, Murase T, Ishizaki S, Tachikawa K, Arima H, Miura Y, Usdin TB, Oiso Y. Centrally administered tuberoinfundibular peptide of 39 residues inhibits arginine vasopressin release in conscious rats. Endocrinology, 2003; 144: 2791-2796.
    3. Tachikawa K, Yokoi H, Nagasaki H, Arima H, Murase T, Sugimura Y, Miura Y, Hirabayashi M, Oiso Y. Altered cardiovascular regulation in arginine vasopressin-overexpressing transgenic rat. Am J Physiol Endocrinol Metab, 2003; 285: E1161-1166.
  • 2002年
    1. Ishizaki S, Murase T, Sugimura Y, Kakiya S, Yokoi H, Tachikawa K, Arima H, Miura Y, Oiso Y. Role of ghrelin in the regulation of vasopressin release in conscious rats. Endocrinology, 2002; 143: 1589-1593.
    2. Nagasaki H, Yokoi H, Arima H, Hirabayashi M, Ishizaki S, Tachikawa K, Murase T, Miura Y, Oiso Y. Overexpression of vasopressin in the rat transgenic for the metallothionein-vasopressin fusion gene. J Endocrinol, 2002; 173: 35-44.
    3. Yambe Y, Arima H, Kakiya S, Murase T, Oiso Y. Diurnal changes in arginine vasopressin gene transcription in the rat suprachiasmatic nucleus. Brain Res Mol Brain Res, 2002; 104: 132-136.
    4. Yokoi H, Nagasaki H, Tachikawa K, Arima H, Murase T, Miura Y, Hirabayashi M, Oiso Y. Adaptation to sustained high plasma vasopressin in water and electrolyte homeostasis in the rat transgenic for the metallothionein-vasopressin fusion gene. J Endocrinol, 2002; 173: 23-33.
  • 2000年
    1. Kakiya S, Arima H, Yokoi H, Murase T, Yambe Y, Oiso Y. Effects of acute hypotensive stimuli on arginine vasopressin gene transcription in the rat hypothalamus. Am J Physiol Endocrinol Metab, 2000; 279: E886-892.
    2. Kakiya S, Murase T, Arima H, Yokoi H, Iwasaki Y, Miura Y, Oiso Y. Role of endogenous nociceptin in the regulation of arginine vasopressin release in conscious rats. Endocrinology, 2000; 141: 4466-4471.
    3. Yambe Y, Watanabe-Tomita Y, Kakiya S, Yokoi H, Nagasaki H, Arima H, Murase T, Yuasa H, Kondo K, Yamashita H, Oiso Y. Analysis of the vasopressin system and water regulation in genetically polydipsic mice. Am J Physiol Endocrinol Metab, 2000; 278: E189-194.
  • 1999年
    1. Arima H, Kondo K, Kakiya S, Nagasaki H, Yokoi H, Yambe Y, Murase T, Iwasaki Y, Oiso Y. Rapid and sensitive vasopressin heteronuclear RNA responses to changes in plasma osmolality. J Neuroendocrinol, 1999; 11: 337-341.
  • 1998年
    1. Arima H, Kondo K, Murase T, Yokoi H, Iwasaki Y, Saito H, Oiso Y. Regulation of vasopressin synthesis and release by area postrema in rats. Endocrinology, 1998; 139: 1481-1486.
    2. Kakiya S, Yokoi H, Arima H, Iwasaki Y, Oki Y, Oiso Y. Central administration of urocortin inhibits vasopressin release in conscious rats. Neurosci Lett, 1998; 248: 144-146.
    3. Mizuno Y, Kondo K, Terashima Y, Arima H, Murase T, Oiso Y. Anorectic effect of pituitary adenylate cyclase activating polypeptide (PACAP) in rats: lack of evidence for involvement of hypothalamic neuropeptide gene expression. J Neuroendocrinol, 1998; 10: 611-616.
    4. Terashima Y, Kondo K, Inagaki A, Yokoi H, Arima H, Murase T, Iwasaki Y, Oiso Y. Age-associated decrease in response of rat aquaporin-2 gene expression to dehydration. Life Sci, 1998; 62: 873-882.
    5. Yokoi H, Arima H, Kondo K, Murase T, Iwasaki Y, Yang HY, Oiso Y. Antiserum against neuropeptide FF augments vasopressin release in conscious rats. Peptides, 1998; 19: 393-395.
  • 1996年
    1. Arima H, Murase T, Kondo K, Iwasaki Y, Oiso Y. Centrally administered neuropeptide FF inhibits arginine vasopressin release in conscious rats. Endocrinology, 1996; 137: 1523-1529.
    2. Murase T, Arima H, Kondo K, Oiso Y. Neuropeptide FF reduces food intake in rats. Peptides, 1996; 17: 353-354.
    3. Yokoi H, Arima H, Murase T, Kondo K, Iwasaki Y, Oiso Y. Intracerebroventricular injection of adrenomedullin inhibits vasopressin release in conscious rats. Neurosci Lett, 1996; 216: 65-67.
  • 1995年
    1. Murase T, Kondo K, Arima H, Iwasaki Y, Ito M, Miura Y, Oiso Y. The expression of pituitary adenylate cyclase-activating polypeptide (PACAP) mRNA in rat brain: possible role of endogenous PACAP in vasopressin release. Neurosci Lett, 1995; 185: 103-106.

研究キーワード

バソプレシン、中枢性尿崩症、低ナトリウム血症、リンパ球性漏斗下垂体後葉炎、抗ラブフィリン3A抗体、再生医療、ES細胞、iPS細胞、エキソサイトーシス、浸透圧性脱髄症候群、エネルギーバランス、１型糖尿病、２型糖尿病、肥満症、GIP、GLP-1、インスリン、グルカゴン、グルコース、フルクトース、KATPチャネル、小胞体ストレス

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糖尿病・内分泌内科学　オープンキャンパス

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2022年4月18日撮影

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