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病態内科学糖尿病・内分泌内科学

研究室概要

当科は2003年に第一内科内分泌研究室と第三内科糖尿病研究室が合併し、さらに糖尿病の臨床を担当していた第二内科の先生方も加わって、糖尿病・内分泌内科教室として新たに発足しました。伝統的に東海地区の糖尿病・内分泌の臨床と研究をリードしてきた研究室を母体とする当科では、35の関連施設病院と連携しながら糖尿病や肥満症などの生活習慣病と種々の内分泌疾患について診療および研究を行っています。また、2015年8月には有馬寛先生が当科の教授に就任し、教室員が一丸となってさらなる発展を目指しています。

研究プロジェクト

  1. 家族性中枢性尿崩症の発症機序の解明
    家族性中枢性尿崩症(FNDI)は生後数ヶ月から数年で発症し緩徐に進行する多尿を呈する常染色体優性遺伝性疾患で、原因となる遺伝子変異の大部分はバソプレシン(AVP)の担体タンパクであるニューロフィジンII領域に認められます。我々はFNDIモデルマウスのAVPニューロンにおいて、小胞体の一部に変異タンパクが隔離された区画(ERAC: Endoplasmic reticulum-associated compartment)が形成されることを見出しました。一方で、慢性的な脱水負荷後や老齢FNDIマウスにおけるAVPニューロンでは、ERACへの異常タンパクの封じ込め機構が破綻することで小胞体ストレスは増大し、AVPニューロンは細胞死に向かうことが明らかになりました。ERAC形成の意義は、小胞体に蓄積する異常タンパクを隔離して封じ込めることで小胞体の形態および機能を維持し、小胞体ストレスを軽減することにあると考えられます。現在、ERAC形成機序の解明に向けた研究を行っています。
  2. バゾプレシン(AVP)分泌機構の解明
    AVPはエキソサイトーシスによって分泌されますが、ラブフィリン3a及びSNARE蛋白複合体などのAVP分泌への関与は不明です。我々は、ES細胞から分化誘導したAVP細胞培養系において、遺伝子導入など分子生物学的手法、また AVP顆粒の可視化と全反射蛍光顕微鏡を用いた開口放出の観察などの細胞生物学的手法等を用い、AVP分泌機構の分子学的機序の解明をすすめています。
  3. 浸透圧性脱髄症候群および低ナトリウム(Na)血症の病態の解明、治療法の開発
    低Na血症の治療において、デキサメサゾンが血液脳関門を保護し、またミノサイクリンがミクログリア活性化を抑制することにより浸透圧性脱髄を防止することを報告しました。また、慢性低Na血症が歩行障害を起こし、海馬での長期増強(LTP)が抑制され、記憶障害を生じることを明らかにしました。
  4. リンパ球性下垂体炎など自己免疫性視床下部下垂体炎に関する研究
    ラブフィリン3Aがリンパ球性漏斗下垂体後葉炎(LINH)の主な自己抗原候補であり、血中抗ラブフィリン3A抗体がLINHの診断マーカーであることを発見しました。また、ACTH単独欠損症の自己抗原候補Rab GDI αを同定しました。現在、抗ラブフィリン3A抗体の簡易な診断検査薬の開発、動物モデルの開発の研究などをすすめています。
  5. 視床下部・下垂体の再生医療
    ES細胞やiPS細胞に代表される多能性幹細胞は、無限の自己複製能と、すべての体細胞へ分化する能力とをもっています。従って、医学的に有用な細胞を試験管内で作る際の材料としても注目されています。当科では、ES細胞やiPS細胞を立体的に培養することにより、ホルモン分泌能を備えた視床下部や下垂体組織を分化させる技術を完成させつつあります。再生医療や、疾患特異的iPS細胞を用いた疾患研究へと発展させていきます。
  6. エネルギーバランスの調節機構
    我々の体はホメオスタシス効果により体重は一定に維持されています。これが破綻すると肥満もしくはるい痩となります。生活習慣病の原因である肥満症は、既にパンデミックレベルで蔓延しているにも関わらず有効な内科的治療法は未だ確立しておらず、発症機序の解明および治療法の確立が期待されます。我々は、Cre-lox systemやin vivoの特性を有した視床下部器官培養を用いて肥満の分子機構の解析を行っています。
  7. 栄養素による糖代謝、特に消化管・膵ホルモン分泌調整の分子機構の解明
    Glucose-dependent insulinotropic polypeptide (GIP)やGlucagon-like peptide-1 (GLP-1)は腸管内分泌細胞からグルコースなどの栄養素の刺激により分泌され、膵β細胞からのインスリン分泌を惹起するインクレチンと呼ばれるホルモンです。また、膵島のα細胞からはグルカゴンが分泌され、インスリンと拮抗的に糖代謝の制御を行っています。我々は、現在、腸管内分泌細胞と膵島内分泌細胞におけるグルコースやフルクトースなどの単糖類をはじめとする各栄養素の感知機構の違いをさまざまな遺伝子改変マウスを用いて検討を行っています。
  8. 糖尿病、肥満症を中心とした臨床研究
    東海地方の27医療機関と連携して1型糖尿病に関する大規模な症例登録データベースを構築し、1型糖尿病の実態を明らかにする臨床観察研究に取り組んでいます。また、2型糖尿病についてもIoT技術やAI技術を駆使して生活習慣の改善をめざす臨床介入研究を行っています。

教員

構成員名役職所属
有馬 寛 教授 糖尿病・内分泌内科学
坂野 僚一 講師 糖尿病・内分泌内科学
須賀 英隆 講師 糖尿病・内分泌内科学
後藤 資実 病院講師 糖尿病・内分泌内科学
岩間 信太郎 保体センター講師 健康・スポーツ医学
清野 祐介 助教 糖尿病・内分泌内科学
高木 博史 助教 糖尿病・内分泌内科学
森下 啓明 特任助教 糖尿病・内分泌内科学
伊藤 禎浩 CKD講座助教 循環器・腎臓・糖尿病(CKD)先進医療システム学寄附講座
恒川 卓 病院助教 糖尿病・内分泌内科学
尾上 剛史 病院助教 糖尿病・内分泌内科学

研究実績

  • 2016年
    1. Fujisawa H, Sugimura Y, Takagi H, Mizoguchi H, Takeuchi H, Izumida H, Nakashima K, Ochiai H, Takeuchi S, Kiyota A, Fukumoto K, Iwama S, Takagishi Y, Hayashi Y, Arima H, Komatsu Y, Murata Y, Oiso Y. Chronic Hyponatremia Causes Neurologic and Psychologic Impairments. J Am Soc Nephrol, 2016; 27: 766-780.
    2. Iida A, Seino Y, Fukami A, Maekawa R, Yabe D, Shimizu S, Kinoshita K, Takagi Y, Izumoto T, Ogata H, Ishikawa K, Ozaki N, Tsunekawa S, Hamada Y, Oiso Y, Arima H, Hayashi Y. Endogenous GIP ameliorates impairment of insulin secretion in proglucagon-deficient mice under moderate beta cell damage induced by streptozotocin. Diabetologia, 2016; 59: 1533-1541.
    3. Izumida H, Takagi H, Fujisawa H, Iwata N, Nakashima K, Takeuchi S, Iwama S, Namba T, Komatu Y, Kaibuchi K, Oiso Y, Arima H, Sugimura Y. NMDA receptor antagonist prevents cell death in the hippocampal dentate gyrus induced by hyponatremia accompanying adrenal insufficiency in rats. Exp Neurol, 2016.
    4. Lu W, Hagiwara D, Morishita Y, Tochiya M, Azuma Y, Suga H, Goto M, Banno R, Sugimura Y, Oyadomari S, Mori K, Arima H. Unfolded protein response in hypothalamic cultures of wild-type and ATF6alpha-knockout mice. Neurosci Lett, 2016; 612: 199-203.
    5. Onoue T, Goto M, Tominaga T, Sugiyama M, Tsunekawa T, Hagiwara D, Banno R, Suga H, Sugimura Y, Arima H. Reactive oxygen species mediate insulin signal transduction in mouse hypothalamus. Neurosci Lett, 2016; 619: 1-7.
    6. Shibata M, Banno R, Sugiyama M, Tominaga T, Onoue T, Tsunekawa T, Azuma Y, Hagiwara D, Lu W, Ito Y, Goto M, Suga H, Sugimura Y, Oiso Y, Arima H. AgRP Neuron-Specific Deletion of Glucocorticoid Receptor Leads to Increased Energy Expenditure and Decreased Body Weight in Female Mice on a High-Fat Diet. Endocrinology, 2016; 157: 1457-1466.
    7. Takeuchi S, Iwama S, Takagi H, Kiyota A, Nakashima K, Izumida H, Fujisawa H, Iwata N, Suga H, Watanabe T, Kaibuchi K, Oiso Y, Arima H, Sugimura Y. Tomosyn Negatively Regulates Arginine Vasopressin Secretion in Embryonic Stem Cell-Derived Neurons. PLoS One, 2016; 11: e0164544.
    8. Ozone C, Suga H, Eiraku M, Kadoshima T, Yonemura S, Takata N, Oiso Y, Tsuji T, Sasai Y. Functional anterior pituitary generated in self-organizing culture of human embryonic stem cells. Nat Commun, 2016; 7: 10351.
    9. Seino Y, Maekawa R, Ogata H, Hayashi Y. Carbohydrate-induced secretion of glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1. J Diabetes Investig, 2016; 7 Suppl 1: 27-32.
    10. Ji S, Tokizane K, Ohkawa Y, Ohmi Y, Banno R, Okajima T, Kiyama H, Furukawa K, Furukawa K. Increased a-series gangliosides positively regulate leptin/Ob receptor-mediated signals in hypothalamus of GD3 synthase-deficient mice. Biochem Biophys Res Commun, 2016; 479: 453-460.
  • 2015年
    1. Iwama S, Sugimura Y, Kiyota A, Kato T, Enomoto A, Suzuki H, Iwata N, Takeuchi S, Nakashima K, Takagi H, Izumida H, Ochiai H, Fujisawa H, Suga H, Arima H, Shimoyama Y, Takahashi M, Nishioka H, Ishikawa SE, Shimatsu A, Caturegli P, Oiso Y. Rabphilin-3A as a Targeted Autoantigen in Lymphocytic Infundibulo-neurohypophysitis. J Clin Endocrinol Metab, 2015; 100: E946-954.
    2. Izumoto-Akita T, Tsunekawa S, Yamamoto A, Uenishi E, Ishikawa K, Ogata H, Iida A, Ikeniwa M, Hosokawa K, Niwa Y, Maekawa R, Yamauchi Y, Seino Y, Hamada Y, Hibi H, Arima H, Ueda M, Oiso Y. Secreted factors from dental pulp stem cells improve glucose intolerance in streptozotocin-induced diabetic mice by increasing pancreatic beta-cell function. BMJ Open Diabetes Res Care, 2015; 3: e000128.
    3. Kataoka Y, Nishida S, Hirakawa A, Oiso Y, Arima H. Comparison of incidence of hyponatremia between intranasal and oral desmopressin in patients with central diabetes insipidus. Endocr J, 2015; 62: 195-200.
    4. Kiyota A, Iwama S, Sugimura Y, Takeuchi S, Takagi H, Iwata N, Nakashima K, Suzuki H, Nishioka T, Kato T, Enomoto A, Arima H, Kaibuchi K, Oiso Y. Identification of the novel autoantigen candidate Rab GDP dissociation inhibitor alpha in isolated adrenocorticotropin deficiency. Endocr J, 2015; 62: 153-160.
    5. Niwa Y, Ishikawa K, Ishigami M, Honda T, Achiwa K, Izumoto T, Maekawa R, Hosokawa K, Iida A, Seino Y, Hamada Y, Goto H, Oiso Y, Arima H, Tsunekawa S. Effect of hyperglycemia on hepatocellular carcinoma development in diabetes. Biochem Biophys Res Commun, 2015; 463: 344-350.
    6. Ochiai H, Suga H, Yamada T, Sakakibara M, Kasai T, Ozone C, Ogawa K, Goto M, Banno R, Tsunekawa S, Sugimura Y, Arima H, Oiso Y. BMP4 and FGF strongly induce differentiation of mouse ES cells into oral ectoderm. Stem Cell Res, 2015; 15: 290-298.
    7. Takahashi A, Lee RX, Iwasato T, Itohara S, Arima H, Bettler B, Miczek KA, Koide T. Glutamate input in the dorsal raphe nucleus as a determinant of escalated aggression in male mice. J Neurosci, 2015; 35: 6452-6463.
    8. Ishikawa K, Tsunekawa S, Ikeniwa M, Izumoto T, Iida A, Ogata H, Uenishi E, Seino Y, Ozaki N, Sugimura Y, Hamada Y, Kuroda A, Shinjo K, Kondo Y, Oiso Y. Long-term pancreatic beta cell exposure to high levels of glucose but not palmitate induces DNA methylation within the insulin gene promoter and represses transcriptional activity. PLoS One, 2015; 10: e0115350.
    9. Seino Y, Ogata H, Maekawa R, Izumoto T, Iida A, Harada N, Miki T, Seino S, Inagaki N, Tsunekawa S, Oiso Y, Hamada Y. Fructose induces glucose-dependent insulinotropic polypeptide, glucagon-like peptide-1 and insulin secretion: Role of adenosine triphosphate-sensitive K(+) channels. J Diabetes Investig, 2015; 6: 522-526.
    10. Ji S, Ohkawa Y, Tokizane K, Ohmi Y, Banno R, Furukawa K, Kiyama H, Furukawa K. b-Series gangliosides crucially regulate leptin secretion in adipose tissues. Biochem Biophys Res Commun, 2015; 459: 189-195.
  • 2014年
    1. Adachi K, Goto M, Onoue T, Tsunekawa T, Shibata M, Hagimoto S, Ito Y, Banno R, Suga H, Sugimura Y, Oiso Y, Arima H. Mitogen-activated protein kinase phosphatase 1 negatively regulates MAPK signaling in mouse hypothalamus. Neurosci Lett, 2014; 569: 49-54.
    2. Arima H, Morishita Y, Hagiwara D, Hayashi M, Oiso Y. Endoplasmic reticulum stress in vasopressin neurons of familial diabetes insipidus model mice: aggregate formation and mRNA poly(A) tail shortening. Exp Physiol, 2014; 99: 66-71.
    3. Arima H, Wakabayashi T, Nagatani T, Fujii M, Hirakawa A, Murase T, Yambe Y, Yamada T, Yamakawa F, Yamamori I, Yamauchi M, Oiso Y. Adipsia increases risk of death in patients with central diabetes insipidus. Endocr J, 2014; 61: 143-148.
    4. Azuma Y, Hagiwara D, Lu W, Morishita Y, Suga H, Goto M, Banno R, Sugimura Y, Oyadomari S, Mori K, Shiota A, Asai N, Takahashi M, Oiso Y, Arima H. Activating transcription factor 6alpha is required for the vasopressin neuron system to maintain water balance under dehydration in male mice. Endocrinology, 2014; 155: 4905-4914.
    5. Hagiwara D, Arima H, Morishita Y, Wenjun L, Azuma Y, Ito Y, Suga H, Goto M, Banno R, Sugimura Y, Shiota A, Asai N, Takahashi M, Oiso Y. Arginine vasopressin neuronal loss results from autophagy-associated cell death in a mouse model for familial neurohypophysial diabetes insipidus. Cell Death Dis, 2014; 5: e1148.
    6. Takagi H, Sugimura Y, Suzuki H, Iwama S, Izumida H, Fujisawa H, Ogawa K, Nakashima K, Ochiai H, Takeuchi S, Kiyota A, Suga H, Goto M, Banno R, Arima H, Oiso Y. Minocycline prevents osmotic demyelination associated with aquaresis. Kidney Int, 2014; 86: 954-964.
    7. Kato J, Kamiya H, Himeno T, Shibata T, Kondo M, Okawa T, Fujiya A, Fukami A, Uenishi E, Seino Y, Tsunekawa S, Hamada Y, Naruse K, Oiso Y, Nakamura J. Mesenchymal stem cells ameliorate impaired wound healing through enhancing keratinocyte functions in diabetic foot ulcerations on the plantar skin of rats. J Diabetes Complications, 2014; 28: 588-595.
    8. Okawa T, Kamiya H, Himeno T, Seino Y, Tsunekawa S, Hayashi Y, Harada N, Yamada Y, Inagaki N, Seino Y, Oiso Y, Nakamura J. Sensory and motor physiological functions are impaired in gastric inhibitory polypeptide receptor-deficient mice. J Diabetes Investig, 2014; 5: 31-37.
    9. Fujiya A, Nagasaki H, Seino Y, Okawa T, Kato J, Fukami A, Himeno T, Uenishi E, Tsunekawa S, Kamiya H, Nakamura J, Oiso Y, Hamada Y. The role of S100B in the interaction between adipocytes and macrophages. Obesity (Silver Spring), 2014; 22: 371-379.
    10. Ogata H, Seino Y, Harada N, Iida A, Suzuki K, Izumoto T, Ishikawa K, Uenishi E, Ozaki N, Hayashi Y, Miki T, Inagaki N, Tsunekawa S, Hamada Y, Seino S, Oiso Y. KATP channel as well as SGLT1 participates in GIP secretion in the diabetic state. J Endocrinol, 2014; 222: 191-200.
  • 2013年
    1. Arima H, Oiso Y, Juul KV, Norgaard JP. Efficacy and safety of desmopressin orally disintegrating tablet in patients with central diabetes insipidus: results of a multicenter open-label dose-titration study. Endocr J, 2013; 60: 1085-1094.
    2. Hagimoto S, Arima H, Adachi K, Ito Y, Suga H, Sugimura Y, Goto M, Banno R, Oiso Y. Expression of neuropeptide Y and agouti-related protein mRNA stimulated by glucocorticoids is attenuated via NF-kappaB p65 under ER stress in mouse hypothalamic cultures. Neurosci Lett, 2013; 553: 165-169.
    3. Ito Y, Banno R, Shibata M, Adachi K, Hagimoto S, Hagiwara D, Ozawa Y, Goto M, Suga H, Sugimura Y, Bettler B, Oiso Y, Arima H. GABA type B receptor signaling in proopiomelanocortin neurons protects against obesity, insulin resistance, and hypothalamic inflammation in male mice on a high-fat diet. J Neurosci, 2013; 33: 17166-17173.
    4. Hamada Y, Nagasaki H, Fuchigami M, Furuta S, Seino Y, Nakamura J, Oiso Y. The alpha-glucosidase inhibitor miglitol affects bile acid metabolism and ameliorates obesity and insulin resistance in diabetic mice. Metabolism, 2013; 62: 734-742.
    5. Okawa T, Kamiya H, Himeno T, Kato J, Seino Y, Fujiya A, Kondo M, Tsunekawa S, Naruse K, Hamada Y, Ozaki N, Cheng Z, Kito T, Suzuki H, Ito S, Oiso Y, Nakamura J, Isobe K. Transplantation of neural crest-like cells derived from induced pluripotent stem cells improves diabetic polyneuropathy in mice. Cell Transplant, 2013; 22: 1767-1783.
    6. Fukami A, Seino Y, Ozaki N, Yamamoto M, Sugiyama C, Sakamoto-Miura E, Himeno T, Takagishi Y, Tsunekawa S, Ali S, Drucker DJ, Murata Y, Seino Y, Oiso Y, Hayashi Y. Ectopic expression of GIP in pancreatic beta-cells maintains enhanced insulin secretion in mice with complete absence of proglucagon-derived peptides. Diabetes, 2013; 62: 510-518.
    7. Okawa T, Tsunekawa S, Seino Y, Hamada Y, Oiso Y. Deceptive HbA(1)c in a patient with pure red cell aplasia. Lancet, 2013; 382: 366.
    8. Hayashi M, Kataoka Y, Sugimura Y, Kato F, Fukami M, Ogata T, Homma K, Hasegawa T, Oiso Y, Sasano H, Tanaka H. A 68-year-old phenotypically male patient with 21-hydroxylase deficiency and concomitant adrenocortical neoplasm producing testosterone and cortisol. Tohoku J Exp Med, 2013; 231: 75-84.
  • 2012年
    1. Hagiwara D, Arima H, Morishita Y, Goto M, Banno R, Sugimura Y, Oiso Y. BiP mRNA expression is upregulated by dehydration in vasopressin neurons in the hypothalamus in mice. Peptides, 2012; 33: 346-350.
    2. Ito Y, Banno R, Hagimoto S, Ozawa Y, Arima H, Oiso Y. TNFalpha increases hypothalamic PTP1B activity via the NFkappaB pathway in rat hypothalamic organotypic cultures. Regul Pept, 2012; 174: 58-64.
    3. Mizutani N, Ozaki N, Seino Y, Fukami A, Sakamoto E, Fukuyama T, Sugimura Y, Nagasaki H, Arima H, Oiso Y. Reduction of insulin signaling upregulates angiopoietin-like protein 4 through elevated free fatty acids in diabetic mice. Exp Clin Endocrinol Diabetes, 2012; 120: 139-144.
    4. Nagasaki H, Kondo T, Fuchigami M, Hashimoto H, Sugimura Y, Ozaki N, Arima H, Ota A, Oiso Y, Hamada Y. Inflammatory changes in adipose tissue enhance expression of GPR84, a medium-chain fatty acid receptor: TNFalpha enhances GPR84 expression in adipocytes. FEBS Lett, 2012; 586: 368-372.
    5. Ozawa Y, Arima H, Banno R, Ito Y, Goto M, Morishita Y, Sugimura Y, Ozaki N, Nagasaki H, Oiso Y. Lesion of area postrema attenuated hyperphagic responses to glucoprivation, but not transcriptional activation of the neuropeptide Y gene in rats. Neuroreport, 2012; 23: 673-675.
    6. Sakamoto E, Seino Y, Fukami A, Mizutani N, Tsunekawa S, Ishikawa K, Ogata H, Uenishi E, Kamiya H, Hamada Y, Sato H, Harada N, Toyoda Y, Miwa I, Nakamura J, Inagaki N, Oiso Y, Ozaki N. Ingestion of a moderate high-sucrose diet results in glucose intolerance with reduced liver glucokinase activity and impaired glucagon-like peptide-1 secretion. J Diabetes Investig, 2012; 3: 432-440.
    7. Watanabe C, Seino Y, Miyahira H, Yamamoto M, Fukami A, Ozaki N, Takagishi Y, Sato J, Fukuwatari T, Shibata K, Oiso Y, Murata Y, Hayashi Y. Remodeling of hepatic metabolism and hyperaminoacidemia in mice deficient in proglucagon-derived peptides. Diabetes, 2012; 61: 74-84.
  • 2011年
    1. Iwama S, Sugimura Y, Suzuki H, Suzuki H, Murase T, Ozaki N, Nagasaki H, Arima H, Murata Y, Sawada M, Oiso Y. Time-dependent changes in proinflammatory and neurotrophic responses of microglia and astrocytes in a rat model of osmotic demyelination syndrome. Glia, 2011; 59: 452-462.
    2. Morishita Y, Arima H, Hiroi M, Hayashi M, Hagiwara D, Asai N, Ozaki N, Sugimura Y, Nagasaki H, Shiota A, Takahashi M, Oiso Y. Poly(A) tail length of neurohypophysial hormones is shortened under endoplasmic reticulum stress. Endocrinology, 2011; 152: 4846-4855.
    3. Ozawa Y, Arima H, Watanabe M, Shimizu H, Ito Y, Banno R, Sugimura Y, Ozaki N, Nagasaki H, Oiso Y. Repeated glucoprivation delayed hyperphagic responses while activating neuropeptide Y neurons in rats. Peptides, 2011; 32: 763-769.
    4. Himeno T, Kamiya H, Naruse K, Harada N, Ozaki N, Seino Y, Shibata T, Kondo M, Kato J, Okawa T, Fukami A, Hamada Y, Inagaki N, Seino Y, Drucker DJ, Oiso Y, Nakamura J. Beneficial effects of exendin-4 on experimental polyneuropathy in diabetic mice. Diabetes, 2011; 60: 2397-2406.
  • 2010年
    1. Arima H, Oiso Y. Positive effect of baclofen on body weight reduction in obese subjects: a pilot study. Intern Med, 2010; 49: 2043-2047.
    2. Arima H, Oiso Y. Mechanisms underlying progressive polyuria in familial neurohypophysial diabetes insipidus. J Neuroendocrinol, 2010; 22: 754-757.
    3. Hiroi M, Morishita Y, Hayashi M, Ozaki N, Sugimura Y, Nagasaki H, Shiota A, Oiso Y, Arima H. Activation of vasopressin neurons leads to phenotype progression in a mouse model for familial neurohypophysial diabetes insipidus. Am J Physiol Regul Integr Comp Physiol, 2010; 298: R486-493.
    4. Kawada K, Kitagawa K, Kamei S, Inada M, Mitsuma A, Sawaki M, Kikumori T, Fujimoto Y, Arima H, Imai T, Ando Y. The feasibility study of docetaxel in patients with anaplastic thyroid cancer. Jpn J Clin Oncol, 2010; 40: 596-599.
    5. Shimizu H, Arima H, Ozawa Y, Watanabe M, Banno R, Sugimura Y, Ozaki N, Nagasaki H, Oiso Y. Glucocorticoids increase NPY gene expression in the arcuate nucleus by inhibiting mTOR signaling in rat hypothalamic organotypic cultures. Peptides, 2010; 31: 145-149.
    6. Suzuki H, Sugimura Y, Iwama S, Suzuki H, Nobuaki O, Nagasaki H, Arima H, Sawada M, Oiso Y. Minocycline prevents osmotic demyelination syndrome by inhibiting the activation of microglia. J Am Soc Nephrol, 2010; 21: 2090-2098.
    7. Umeda H, Ozaki N, Mizutani N, Fukuyama T, Nagasaki H, Arima H, Oiso Y. Protective effect of hedgehog signaling on cytokine-induced cytotoxicity in pancreatic beta-cells. Exp Clin Endocrinol Diabetes, 2010; 118: 692-698.
    8. Yokota F, Arima H, Hirano M, Uchikawa T, Inden Y, Nagatani T, Oiso Y. Normalisation of plasma growth hormone levels improved cardiac dysfunction due to acromegalic cardiomyopathy with severe fibrosis. BMJ Case Rep, 2010; 2010.
  • 2009年
    1. Arima H, Imamine R, Oiso Y. Ping-pong champion with adrenal insufficiency. BMJ Case Rep, 2009; 2009.
    2. Hayashi M, Arima H, Ozaki N, Morishita Y, Hiroi M, Ozaki N, Nagasaki H, Kinoshita N, Ueda M, Shiota A, Oiso Y. Progressive polyuria without vasopressin neuron loss in a mouse model for familial neurohypophysial diabetes insipidus. Am J Physiol Regul Integr Comp Physiol, 2009; 296: R1641-1649.
    3. Imamine R, Arima H, Kusakabe M, Umeda H, Sato I, Homma K, Usui T, Oiso Y. Genetic analysis of two Japanese patients with non-classical 21-hydroxylase deficiency. Intern Med, 2009; 48: 705-709.
    4. Iwama S, Sugimura Y, Murase T, Hiroi M, Goto M, Hayashi M, Arima H, Oiso Y. Central adiponectin functions to inhibit arginine vasopressin release in conscious rats. J Neuroendocrinol, 2009; 21: 753-759.
    5. Suzuki C, Nagasaki H, Okajima Y, Suga H, Ozaki N, Arima H, Iwasaki Y, Oiso Y. Inflammatory cytokines regulate glycoprotein subunit beta5 of thyrostimulin through nuclear factor-kappaB. Endocrinology, 2009; 150: 2237-2243.
    6. Watanabe M, Arima H, Ozawa Y, Goto M, Shimizu H, Banno R, Sugimura Y, Ozaki N, Nagasaki H, Oiso Y. The medial hypothalamus is required for the feeding response to glucoprivation but not to food deprivation. Neurosci Lett, 2009; 464: 6-9.
    7. Oyama K, Sugimura Y, Murase T, Uchida A, Hayasaka S, Oiso Y, Murata Y. Folic acid prevents congenital malformations in the offspring of diabetic mice. Endocr J, 2009; 56: 29-37.
    8. Sugimura Y, Murase T, Kobayashi K, Oyama K, Hayasaka S, Kanou Y, Oiso Y, Murata Y. Alpha-lipoic acid reduces congenital malformations in the offspring of diabetic mice. Diabetes Metab Res Rev, 2009; 25: 287-294.
    9. Sugimura Y, Murase T, Oyama K, Uchida A, Sato N, Hayasaka S, Kano Y, Takagishi Y, Hayashi Y, Oiso Y, Murata Y. Prevention of neural tube defects by loss of function of inducible nitric oxide synthase in fetuses of a mouse model of streptozotocin-induced diabetes. Diabetologia, 2009; 52: 962-971.
  • 2008年
    1. Okajima Y, Nagasaki H, Suzuki C, Suga H, Ozaki N, Arima H, Hamada Y, Civelli O, Oiso Y. Biochemical roles of the oligosaccharide chains in thyrostimulin, a heterodimeric hormone of glycoprotein hormone subunits alpha 2 (GPA2) and beta 5 (GPB5). Regul Pept, 2008; 148: 62-67.
    2. Shimizu H, Arima H, Watanabe M, Goto M, Banno R, Sato I, Ozaki N, Nagasaki H, Oiso Y. Glucocorticoids increase neuropeptide Y and agouti-related peptide gene expression via adenosine monophosphate-activated protein kinase signaling in the arcuate nucleus of rats. Endocrinology, 2008; 149: 4544-4553.
    3. Suga H, Nagasaki H, Kondo TA, Okajima Y, Suzuki C, Ozaki N, Arima H, Yamamoto T, Ozaki N, Akai M, Sato A, Uozumi N, Inoue M, Hasegawa M, Oiso Y. Novel treatment for lithium-induced nephrogenic diabetes insipidus rat model using the Sendai-virus vector carrying aquaporin 2 gene. Endocrinology, 2008; 149: 5803-5810.
    4. Watanabe M, Arima H, Fukushima K, Goto M, Shimizu H, Hayashi M, Banno R, Sato I, Ozaki N, Nagasaki H, Oiso Y. Direct and indirect modulation of neuropeptide Y gene expression in response to hypoglycemia in rat arcuate nucleus. FEBS Lett, 2008; 582: 3632-3638.
  • 2007年
    1. Banno R, Arima H, Hayashi M, Goto M, Watanabe M, Sato I, Ozaki N, Nagasaki H, Ozaki N, Oiso Y. Central administration of melanocortin agonist increased insulin sensitivity in diet-induced obese rats. FEBS Lett, 2007; 581: 1131-1136.
    2. Goto M, Arima H, Hiroi M, Shimizu H, Watanabe M, Hayashi M, Banno R, Sato I, Ozaki N, Nagasaki H, Oiso Y. Insulin is not a prerequisite for rapid regulation of neuropeptide Y gene transcription in the arcuate nucleus in food-restricted rats. Neurosci Lett, 2007; 420: 61-65.
    3. Sato I, Arima H, Ozaki N, Ozaki N, Watanabe M, Goto M, Shimizu H, Hayashi M, Banno R, Nagasaki H, Oiso Y. Peripherally administered baclofen reduced food intake and body weight in db/db as well as diet-induced obese mice. FEBS Lett, 2007; 581: 4857-4864.
    4. Suzuki C, Nagasaki H, Okajima Y, Suga H, Arima H, Iwasaki Y, Oiso Y. The LIM domain homeobox gene isl-1 is a positive regulator of glycoprotein alpha 2 (GPA2), a subunit of thyrostimulin. Regul Pept, 2007; 142: 60-67.
    5. Takefuji S, Murase T, Sugimura Y, Takagishi Y, Hayasaka S, Oiso Y, Murata Y. Role of microglia in the pathogenesis of osmotic-induced demyelination. Exp Neurol, 2007; 204: 88-94.
  • 2006年
    1. Goto M, Arima H, Watanabe M, Hayashi M, Banno R, Sato I, Nagasaki H, Oiso Y. Ghrelin increases neuropeptide Y and agouti-related peptide gene expression in the arcuate nucleus in rat hypothalamic organotypic cultures. Endocrinology, 2006; 147: 5102-5109.
    2. Hayashi M, Arima H, Goto M, Banno R, Watanabe M, Sato I, Nagasaki H, Oiso Y. Vasopressin gene transcription increases in response to decreases in plasma volume, but not to increases in plasma osmolality, in chronically dehydrated rats. Am J Physiol Endocrinol Metab, 2006; 290: E213-217.
    3. Murase T, Sugimura Y, Takefuji S, Oiso Y, Murata Y. Mechanisms and therapy of osmotic demyelination. Am J Med, 2006; 119: S69-73.
  • 2005年
    1. Sato I, Arima H, Ozaki N, Watanabe M, Goto M, Hayashi M, Banno R, Nagasaki H, Oiso Y. Insulin inhibits neuropeptide Y gene expression in the arcuate nucleus through GABAergic systems. J Neurosci, 2005; 25: 8657-8664.
    2. Sugimura Y, Murase T, Takefuji S, Hayasaka S, Takagishi Y, Oiso Y, Murata Y. Protective effect of dexamethasone on osmotic-induced demyelination in rats. Exp Neurol, 2005; 192: 178-183.
  • 2004年
    1. Banno R, Arima H, Sato I, Hayashi M, Goto M, Sugimura Y, Murase T, Oiso Y. The melanocortin agonist melanotan II increases insulin sensitivity in OLETF rats. Peptides, 2004; 25: 1279-1286.
    2. Ishizaki S, Murase T, Sugimura Y, Banno R, Arima H, Miura Y, Oiso Y. Leukemia inhibitory factor stimulates vasopressin release in rats. Neurosci Lett, 2004; 359: 77-80.
    3. Kondo N, Arima H, Banno R, Kuwahara S, Sato I, Oiso Y. Osmoregulation of vasopressin release and gene transcription under acute and chronic hypovolemia in rats. Am J Physiol Endocrinol Metab, 2004; 286: E337-346.
  • 2003年
    1. Kuwahara S, Arima H, Banno R, Sato I, Kondo N, Oiso Y. Regulation of vasopressin gene expression by cAMP and glucocorticoids in parvocellular neurons of the paraventricular nucleus in rat hypothalamic organotypic cultures. J Neurosci, 2003; 23: 10231-10237.
    2. Sugimura Y, Murase T, Ishizaki S, Tachikawa K, Arima H, Miura Y, Usdin TB, Oiso Y. Centrally administered tuberoinfundibular peptide of 39 residues inhibits arginine vasopressin release in conscious rats. Endocrinology, 2003; 144: 2791-2796.
    3. Tachikawa K, Yokoi H, Nagasaki H, Arima H, Murase T, Sugimura Y, Miura Y, Hirabayashi M, Oiso Y. Altered cardiovascular regulation in arginine vasopressin-overexpressing transgenic rat. Am J Physiol Endocrinol Metab, 2003; 285: E1161-1166.
  • 2002年
    1. Ishizaki S, Murase T, Sugimura Y, Kakiya S, Yokoi H, Tachikawa K, Arima H, Miura Y, Oiso Y. Role of ghrelin in the regulation of vasopressin release in conscious rats. Endocrinology, 2002; 143: 1589-1593.
    2. Nagasaki H, Yokoi H, Arima H, Hirabayashi M, Ishizaki S, Tachikawa K, Murase T, Miura Y, Oiso Y. Overexpression of vasopressin in the rat transgenic for the metallothionein-vasopressin fusion gene. J Endocrinol, 2002; 173: 35-44.
    3. Yambe Y, Arima H, Kakiya S, Murase T, Oiso Y. Diurnal changes in arginine vasopressin gene transcription in the rat suprachiasmatic nucleus. Brain Res Mol Brain Res, 2002; 104: 132-136.
    4. Yokoi H, Nagasaki H, Tachikawa K, Arima H, Murase T, Miura Y, Hirabayashi M, Oiso Y. Adaptation to sustained high plasma vasopressin in water and electrolyte homeostasis in the rat transgenic for the metallothionein-vasopressin fusion gene. J Endocrinol, 2002; 173: 23-33.
  • 2000年
    1. Kakiya S, Arima H, Yokoi H, Murase T, Yambe Y, Oiso Y. Effects of acute hypotensive stimuli on arginine vasopressin gene transcription in the rat hypothalamus. Am J Physiol Endocrinol Metab, 2000; 279: E886-892.
    2. Kakiya S, Murase T, Arima H, Yokoi H, Iwasaki Y, Miura Y, Oiso Y. Role of endogenous nociceptin in the regulation of arginine vasopressin release in conscious rats. Endocrinology, 2000; 141: 4466-4471.
    3. Yambe Y, Watanabe-Tomita Y, Kakiya S, Yokoi H, Nagasaki H, Arima H, Murase T, Yuasa H, Kondo K, Yamashita H, Oiso Y. Analysis of the vasopressin system and water regulation in genetically polydipsic mice. Am J Physiol Endocrinol Metab, 2000; 278: E189-194.
  • 1999年
    1. Arima H, Kondo K, Kakiya S, Nagasaki H, Yokoi H, Yambe Y, Murase T, Iwasaki Y, Oiso Y. Rapid and sensitive vasopressin heteronuclear RNA responses to changes in plasma osmolality. J Neuroendocrinol, 1999; 11: 337-341.
  • 1998年
    1. Arima H, Kondo K, Murase T, Yokoi H, Iwasaki Y, Saito H, Oiso Y. Regulation of vasopressin synthesis and release by area postrema in rats. Endocrinology, 1998; 139: 1481-1486.
    2. Kakiya S, Yokoi H, Arima H, Iwasaki Y, Oki Y, Oiso Y. Central administration of urocortin inhibits vasopressin release in conscious rats. Neurosci Lett, 1998; 248: 144-146.
    3. Mizuno Y, Kondo K, Terashima Y, Arima H, Murase T, Oiso Y. Anorectic effect of pituitary adenylate cyclase activating polypeptide (PACAP) in rats: lack of evidence for involvement of hypothalamic neuropeptide gene expression. J Neuroendocrinol, 1998; 10: 611-616.
    4. Terashima Y, Kondo K, Inagaki A, Yokoi H, Arima H, Murase T, Iwasaki Y, Oiso Y. Age-associated decrease in response of rat aquaporin-2 gene expression to dehydration. Life Sci, 1998; 62: 873-882.
    5. Yokoi H, Arima H, Kondo K, Murase T, Iwasaki Y, Yang HY, Oiso Y. Antiserum against neuropeptide FF augments vasopressin release in conscious rats. Peptides, 1998; 19: 393-395.
  • 1996年
    1. Arima H, Murase T, Kondo K, Iwasaki Y, Oiso Y. Centrally administered neuropeptide FF inhibits arginine vasopressin release in conscious rats. Endocrinology, 1996; 137: 1523-1529.
    2. Murase T, Arima H, Kondo K, Oiso Y. Neuropeptide FF reduces food intake in rats. Peptides, 1996; 17: 353-354.
    3. Yokoi H, Arima H, Murase T, Kondo K, Iwasaki Y, Oiso Y. Intracerebroventricular injection of adrenomedullin inhibits vasopressin release in conscious rats. Neurosci Lett, 1996; 216: 65-67.
  • 1995年
    1. Murase T, Kondo K, Arima H, Iwasaki Y, Ito M, Miura Y, Oiso Y. The expression of pituitary adenylate cyclase-activating polypeptide (PACAP) mRNA in rat brain: possible role of endogenous PACAP in vasopressin release. Neurosci Lett, 1995; 185: 103-106.

研究キーワード

バソプレシン、中枢性尿崩症、低ナトリウム血症、リンパ球性漏斗下垂体後葉炎、抗ラブフィリン3A抗体、再生医療、ES細胞、iPS細胞、エキソサイトーシス、浸透圧性脱髄症候群、エネルギーバランス、1型糖尿病、2型糖尿病、肥満症、GIP、GLP-1、インスリン、グルカゴン、グルコース、フルクトース、KATPチャネル、小胞体ストレス

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2016年6月13日撮影
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