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Top > 研究室紹介 > 高次医用科学 > 臓器病態診断学／病態構造解析学(臨床検査医学)

高次医用科学臓器病態診断学／病態構造解析学(臨床検査医学)

概要

病理診断および病理診断に基づく研究は、病変そのものを観察するところから始まります。病理診断は3年間の研修期間を経て病理専門医を取得するところにとどまらず、実際の診断の経験と臨床とのディスカッションの蓄積により生涯にわたり磨かれていくものと言えます。大学病院の豊富な症例を通じた病理診断の研修と、症例を用いた臨床病理学的な研究、さらには病理組織標本を活用した遺伝子解析などの手法で疾患の本態に迫るのを目標としています。狭い専門分野のみでなく、全科横断的な視点を持ち、他科・他大学とのコラボレーションを通じてより幅広い知識の集積、病理学的な素養を培う事が期待されます。現在あるプロジェクトにとどまらず興味のある分野で研究を行う事が可能です。

研究プロジェクト

1．希少唾液腺腫瘍の形態学的評価、および遺伝子学的な変化との相関の検討。

2．唾液腺腫瘍の再現性の高い診断、予後予測因子の検討。

教員

構成員名役職所属
加留部 謙之輔 教授 臓器病態診断学
中黒 匡人 准教授 病態構造解析学

研究実績

  • 2022年
    1. Tatetsu H, Imakane D, Nosaka K, Karube K, Honda Y, Higuchi Y, Yasunaga JI, Mikami Y, Matsuoka M. [Follicular T-cell lymphoma successfully treated with long-term corticosteroid]. Rinsho Ketsueki .2022;63(11):1497-1502.
    2. Gonzalez-Farre B, Ramis-Zaldivar JE, Castrejón de Anta N, Rivas-Delgado A, Nadeu F, Salmeron-Villalobos J, Enjuanes A, Karube K, Balagué O, Cobo F, Kelleher N, Victoria I, Veloza L, Teixido C, Giné E, Lopez-Guerra M, Quintanilla-Martinez L, Lopez-Guillermo A, Salaverria I, Campo E. Intravascular Large B-Cell Lymphoma Genomic Profile Is Characterized by Alterations in Genes Regulating NF-κB and Immune Checkpoints. Am J Surg Pathol .2023 Feb 1;47(2):202-211.
    3. Aoki Y, Tome Y, Oshiro H, Katsuki R, Tamaki T, Wada N, Karube K, Nishida K. Wide excision alone for elderly patients aged > 70 years old with soft tissue sarcomas. Medicine 2022 Sep 9;101(36):e30127.
    4. de Leval L, Alizadeh AA, Bergsagel PL, Campo E, Davies A, Dogan A, Fitzgibbon J, Horwitz SM, Melnick AM, Morice WG, Morin RD, Nadel B, Pileri SA, Rosenquist R, Rossi D, Salaverria I, Steidl C, Treon SP, Zelenetz AD, Advani RH, Allen CE, Ansell SM, Chan WC, Cook JR, Cook LB, d'Amore F, Dirnhofer S, Dreyling M, Dunleavy K, Feldman AL, Fend F, Gaulard P, Ghia P, Gribben JG, Hermine O, Hodson DJ, Hsi ED, Inghirami G, Jaffe ES, Karube K, Kataoka K, Klapper W, Kim WS, King RL, Ko YH, LaCasce AS, Lenz G, Martin-Subero JI, Piris MA, Pittaluga S, Pasqualucci L, Quintanilla-Martinez L, Rodig SJ, Rosenwald A, Salles GA, San-Miguel J, Savage KJ, Sehn LH, Semenzato G, Staudt LM, Swerdlow SH, Tam CS, Trotman J, Vose JM, Weigert O, Wilson WH, Winter JN, Wu CJ, Zinzani PL, Zucca E, Bagg A, Scott DW. Genomic profiling for clinical decision making in lymphoid neoplasms. Blood 2022 Nov 24;140(21):2193-2227.
    5. Alaggio R, Amador C, Anagnostopoulos I, Attygalle AD, Araujo IBO, Berti E, Bhagat G, Borges AM, Boyer D, Calaminici M, Chadburn A, Chan JKC, Cheuk W, Chng WJ, Choi JK, Chuang SS, Coupland SE, Czader M, Dave SS, de Jong D, Du MQ, Elenitoba-Johnson KS, Ferry J, Geyer J, Gratzinger D, Guitart J, Gujral S, Harris M, Harrison CJ, Hartmann S, Hochhaus A, Jansen PM, Karube K, Kempf W, Khoury J, Kimura H, Klapper W, Kovach AE, Kumar S, Lazar AJ, Lazzi S, Leoncini L, Leung N, Leventaki V, Li XQ, Lim MS, Liu WP, Louissaint A Jr, Marcogliese A, Medeiros LJ, Michal M, Miranda RN, Mitteldorf C, Montes-Moreno S, Morice W, Nardi V, Naresh KN, Natkunam Y, Ng SB, Oschlies I, Ott G, Parrens M, Pulitzer M, Rajkumar SV, Rawstron AC, Rech K, Rosenwald A, Said J, Sarkozy C, Sayed S, Saygin C, Schuh A, Sewell W, Siebert R, Sohani AR, Tooze R, Traverse-Glehen A, Vega F, Vergier B, Wechalekar AD, Wood B, Xerri L, Xiao W . The 5th edition of the World Health Organization Classification of Haematolymphoid Tumours: Lymphoid Neoplasms. Leukemia 2022 Jul;36(7):1720-1748.
    6. Sakihama S, Karube K. Genetic Alterations in Adult T-Cell Leukemia/Lymphoma: Novel Discoveries with Clinical and Biological Significance. Cancers 2022 May 12;14(10):2394.
    7. Kubo T, Hirayama Y, Sakihama S, Kikuchi T, Hirohashi Y, Tsujiwaki M, Karube K, Hasegawa T, Torigoe T. Spindle cell tumor with histiocytic and myogenic marker expression in the lymph node of a human T-cell leukemia virus type 1 carrier. Pathol Res Pract 2022 Jun;234:153935.
    8. Kato M, Imaizumi N, Tanaka R, Mizuguchi M, Hayashi M, Miyagi T, Uchihara J, Ohshiro K, Todoroki J, Karube K, Masuzaki H, Tanaka Y, Fukushima T. Elevation of the Plasma Levels of TNF Receptor 2 in Association with Those of CD25, OX40, and IL-10 and HTLV-1 Proviral Load in Acute Adult T-Cell Leukemia.Viruses 2022 Apr 3;14(4):751.
    9. Siddiqui F, Perez Silos V, Karube K, Yasin Goksu S, Nandakumar S, Saygin C, Onajin O, Prabu SS, Gurbuxani S, Arber DA, Tjota M, Segal J, Smith SM, Murga-Zamalloa CA, Venkataraman G. B-cell lymphoma-2 downregulation is a useful feature supporting a neoplastic phenotype in mature T-cell lymphomas. Hum Pathol 2022 Jul;125:48-58.
    10. Nakamura T, Yasunaga JI, Yokoo K, Takatori M, Kawakami F, Higuchi Y, Tatetsu H, Nosaka K, Karube K, Mikami Y, Matsuoka M. Adult T-cell leukemia/lymphoma diagnosed by RNA in situ hybridization for HTLV-1 bZIP factor. Rinsho Ketsueki 2022;63(2):89-93.
    11. Karube K, Nakada N, Sakamoto K, Takeuchi K. Blastic plasmacytoid dendritic cell neoplasm with prominent intracytoplasmic vacuoles: A challenging diagnosis. Pathol Int 2022 Mar;72(3):211-213.
    12. Aarakaki H, Karube K. Small-cell pattern of DUSP22 rearranged ALK-negative anaplastic large-cell lymphoma with leukemic phase. Blood 2022 Jan 20;139(3):465.
    13. Karube K. Current progress of the tumor microenvironment in lymphoid malignancies. J Clin Exp Hematop 2021;61(4):180-181.
    14. Shiraishi J, Hatano M, Funakoshi I, Murata Y, Maeshima A, Ito F, Morinaga S, Nakaguro M. Papillary variant of adenoid cystic carcinoma of the maxillary sinus. Pathol Int. 2023 Jan 13. doi: 10.1111/pin.13307. Epub ahead of print. PMID: 36636923.
    15. Kohsaka S, Tada Y, Ando M, Nakaguro M, Shirai Y, Ueno T, Kojima S, Hirai H, Saigusa N, Kano S, Tsukahara K, Togashi T, Ozawa H, Kondo T, Okami K, Takahashi H, Kawakita D, Fushimi C, Suzuki T, Shimizu A, Okamoto I, Okada T, Sato Y, Imanishi Y, Watanabe Y, Sakai A, Ebisumoto K, Sato Y, Urano M, Honma Y, Yamazaki K, Ueki Y, Hanazawa T, Saito Y, Shimura T, Nagao T, Mano H. Identification of novel prognostic and predictive biomarkers in salivary duct carcinoma via comprehensive molecular profiling. NPJ Precis Oncol. 2022 Nov 4;6(1):82. doi: 10.1038/s41698-022-00324-1. PMID: 36333410.
    16. Gibo N, Hamaguchi T, Miki Y, Yamamura T, Nakaguro M, Ito M, Nakamuara M, Kawashima H, Hirayama M, Hirooka Y, Wakabayashi K, Ohno K. Examination of Abnormal Alpha-synuclein Aggregates in the Enteric Neural Plexus in Patients with Ulcerative Colitis. J Gastrointestin Liver Dis. 2022 Sep 15;31(3):290-300.
    17. Kawakita D, Nagao T, Takahashi H, Kano S, Honma Y, Hirai H, Saigusa N, Akazawa K, Tani K, Ojiri H, Tsukahara K, Ozawa H, Okami K, Kondo T, Togashi T, Fushimi C, Shimura T, Shimizu A, Okamoto I, Okada T, Imanishi Y, Watanabe Y, Otsuka K, Sakai A, Ebisumoto K, Sato Y, Yamazaki K, Ueki Y, Hanazawa T, Saito Y, Ando M, Matsuki T, Nakaguro M, Sato Y, Urano M, Utsumi Y, Kohsaka S, Saotome T, Tada Y. Survival benefit of HER2-targeted or androgen deprivation therapy in salivary duct carcinoma. Ther Adv Med Oncol. 2022 Sep 6;14:17588359221119538.
    18. Fukumura M, Ishibashi K, Nakaguro M, Nagao T, Saida K, Urano M, Tanigawa M, Hirai H, Yagyuu T, Kikuchi K, Yada N, Sugita Y, Miyabe M, Hasegawa S, Goto M, Yamamoto H, Ohuchi T, Kusafuka K, Ogawa I, Suzuki H, Notohara K, Shimoda M, Tada Y, Kirita T, Takata T, Morinaga S, Maeda H, Warnakulasuriya S, Miyabe S, Nagao T. Salivary Gland Polymorphous Adenocarcinoma: Clinicopathological Features and Gene Alterations in 36 Japanese Patients. J Oral Pathol Med. 2022 Sep;51(8):710-720.
    19. Nakaguro M, Sadow PM, Hu R, Hattori H, Kuwabara K, Tsuzuki T, Urano M, Nagao T, Faquin WC. NKX3.1 Expression in Salivary Gland Intraductal Papillary Mucinous Neoplasm: A Low-Grade Subtype of Salivary Gland Mucinous Adenocarcinoma. Head Neck Pathol. 2022 Dec;16(4):1114-1123.
    20. Sakamoto S, Miyauchi M, Ando T, Fujihara M, Nakaguro M, Nagao T, Ogawa I. Non-sebaceous lymphadenoma-like mucoepidermoid carcinoma: A case report. Pathol Int. 2022 Jul;72(7):371-375.
    21. Saigusa N, Hirai H, Tada Y, Kawakita D, Nakaguro M, Tsukahara K, Kano S, Ozawa H, Kondo T, Okami K, Togashi T, Sato Y, Urano M, Kajiwara M, Shimura T, Fushimi C, Shimizu A, Okamoto I, Okada T, Suzuki T, Imanishi Y, Watanabe Y, Sakai A, Ebisumoto K, Sato Y, Honma Y, Yamazaki K, Ueki Y, Hanazawa T, Saito Y, Takahashi H, Ando M, Kohsaka S, Matsuki T, Nagao T. The Role of the EZH2 and H3K27me3 Expression as a Predictor of Clinical Outcomes in Salivary Duct Carcinoma Patients: A Large-Series Study with Emphasis on the Relevance to the Combined Androgen Blockade and HER2-Targeted Therapy. Front Oncol. 2022 Feb 3;11:779882.
    22. Hashimoto N, Ko K, Yokota T, Kohno K, Nakaguro M, Nakamura S, Takeuchi I, Hontani H. Subtype classification of malignant lymphoma using immunohistochemical staining pattern. Int J Comput Assist Radiol Surg. 2022 Jul;17(7):1379-1389.
    23. Yoshida T, Muramatsu H, Wakamatsu M, Taniguchi R, Ichikawa D, Nakaguro M, Natsume A, Takahashi Y. Microsatellite instability-high is rare events in refractory pediatric solid tumors. Pediatr Hematol Oncol. 2022 Aug;39(5):468-474.
    24. Kawano T, Tsuyuki Y, Suzuki Y, Shimada K, Kato S, Takahara T, Mori M, Nakaguro M, Sakakibara A, Nakamura S, Satou A. Clinicopathologic Analysis of Primary Adrenal Diffuse Large B-Cell Lymphoma: A Reappraisal of 23 Japanese Patients Based on EBV Association and PD-L1 Expression in Tumor Cells. Am J Surg Pathol. 2021 Dec 1;45(12):1606-1615.
    25. Viswanathan K, Beg S, He B, Zhang T, Cantley R, Lubin DJ, Shi Q, Maleki Z, Asiry S, Rao R, Katabi N, Nakaguro M, Faquin WC, Sadow PM, Siddiqui MT, Scognamiglio T. NR4A3 Immunostain Is a Highly Sensitive and Specific Marker for Acinic Cell Carcinoma in Cytologic and Surgical Specimens. Am J Clin Pathol. 2022 Jan 6;157(1):98-108.
    26. Higuchi K, Urano M, Akiba J, Nogami M, Hirata Y, Zukeran Y, Moriyoshi K, Tada Y, Fukushima M, Obayashi M, Sakamoto S, Kuraoka K, Kira K, Kawahara A, Kato T, Tanigawa M, Nakaguro M, Yamamoto H, Nagao T. A multi-institutional study of salivary gland cytopathology: Application of the Milan System for Reporting Salivary Gland Cytopathology in Japan. Cancer Cytopathol. 2022 Jan;130(1):30-40.
  • 2021年
    1. Kawano T, Tsuyuki Y, Suzuki Y, Shimada K, Kato S, Takahara T, Mori M, Nakaguro M, Sakakibara A, Nakamura S, Satou A. Clinicopathologic Analysis of Primary Adrenal Diffuse Large B-Cell Lymphoma: A Reappraisal of 23 Japanese Patients Based on EBV Association and PD-L1 Expression in Tumor Cells. Am J Surg Pathol. 2021 Sep 16. Epub ahead of print. PMID: 34534136.
    2. Viswanathan K, Beg S, He B, Zhang T, Cantley R, Lubin DJ, Shi Q, Maleki Z, Asiry S, Rao R, Katabi N, Nakaguro M, Faquin WC, Sadow PM, Siddiqui MT, Scognamiglio T. NR4A3 Immunostain Is a Highly Sensitive and Specific Marker for Acinic Cell Carcinoma in Cytologic and Surgical Specimens. Am J Clin Pathol. 2021 Sep Epub ahead of print. PMID: 34508546.
    3. Higuchi K, Urano M, Akiba J, Nogami M, Hirata Y, Zukeran Y, Moriyoshi K, Tada Y, Fukushima M, Obayashi M, Sakamoto S, Kuraoka K, Kira K, Kawahara A, Kato T, Tanigawa M, Nakaguro M, Yamamoto H, Nagao T. A multi-institutional study of salivary gland cytopathology: Application of the Milan System for Reporting Salivary Gland Cytopathology in Japan. Cancer Cytopathol. 2021 Sep Epub ahead of print. PMID: 34478237.
    4. Ichikawa D, Yamashita K, Okuno Y, Muramatsu H, Murakami N, Suzuki K, Kojima D, Kataoka S, Hamada M, Taniguchi R, Nishikawa E, Kawashima N, Narita A, Nishio N, Hama A, Kasai K, Mizuno S, Shimoyama Y, Nakaguro M, Okita H, Kojima S, Nakazawa A, Takahashi Y. Integrated diagnosis based on transcriptome analysis in suspected pediatric sarcomas. NPJ Genom Med. 2021 Jun 15;6(1):49.
    5. Mutsuga M, Narita Y, Tokuda Y, Uchida W, Ito H, Terazawa S, Nakaguro M, Usui A. Predictors of failure of mitral valve repair using artificial chordae. Ann Thorac Surg. 2022 Apr;113(4):1136-1143.
    6. Fisch AS, Laklouk I, Nakaguro M, Nosé V, Wirth LJ, Deschler DG, Faquin WC, Dias-Santagata D, Sadow PM. Intraductal Carcinoma of the Salivary Gland with NCOA4-RET: Expanding the Morphologic Spectrum and an Algorithmic Diagnostic Approach. Hum Pathol. 2021 May 12;114:74-89.
    7. Bishop JA, Sajed DP, Weinreb I, Dickson BC, Bilodeau EA, Agaimy A, Franchi A, Khurram SA, Da Forno P, Robledo J, Kalmar JR, Aguirre S, Krane JF, Tapia JL, Kiss K, Cordell K, Rosebush M, Barrett AW, Oda D, Assaad A, Nagao T, Kawakami F, Nakaguro M, Zahir I, Wakeman K, Ihrler S, Chenevert J, Lin YL, Westra WH, Gagan J, Rooper LM. Microsecretory Adenocarcinoma of Salivary Glands: An Expanded Series of 24 Cases. Head Neck Pathol. 2021 May 12. Epub ahead of print. PMID: 33982215.
    8. Yagi H, Nakaguro M, Ito M, Okumura Y, Takahashi S, Aoshima Y, Enomoto Y, Meguro S, Kawasaki H, Kosugi I, Shimoyama Y, Ogawa H, Tateyama H, Iwashita T. Difference in the distribution of tumor-infiltrating CD8+ T cells and FOXP3+ T cells between micronodular thymoma with lymphoid stroma and micronodular thymic carcinoma with lymphoid stroma. Pathol Int. 2021 Jul;71(7):453-462.
    9. Morita N, Murase T, Ueda K, Nagao T, Kusafuka K, Nakaguro M, Urano M, Taguchi K, Yamamoto H, Kano S, Tada Y, Tsukahara K, Okami K, Onitsuka T, Fujimoto Y, Kawakita D, Sakurai K, Nagao T, Hanai N, Kawata R, Hato N, Otsuki N, Nibu K, Inagaki H. Pathological evaluation of tumor grade for salivary adenoid cystic carcinoma: a proposal of an objective grading system. Cancer Science. 2021 Mar;112(3):1184-1195.
    10. Nakaguro M, Tanigawa M, Hirai H, Yamamoto Y, Urano M, Takahashi RH, Sukeda A, Okumura Y, Honda S, Tasaki K, Shimizu A, Tsukahara K, Tada Y, Matsubayashi J, Faquin WC, Sadow PM, Nagao T. The Diagnostic Utility of RAS Q61R Mutation-specific Immunohistochemistry in Epithelial-Myoepithelial Carcinoma. Am J Surg Pathol. 2021 Jul 1;45(7):885-894.
    11. Nakaguro M, Mino-Kenudson M, Urano M, Ogawa I, Honda Y, Hirai H, Tanigawa M, Sukeda A, Kajiwara N, Ohira T, Ikeda N, Mikami Y, Tada Y, Ikeda JI, Matsubayashi J, Faquin WC, Sadow PM, Nagao T. Sialadenoma Papilliferum of the Bronchus: An Unrecognized Bronchial Counterpart of the Salivary Gland Tumor With Frequent BRAF V600E Mutations. Am J Surg Pathol. 2021 May 1;45(5):662-671.
    12. Morita N, Murase T, Ueda K, Nagao T, Kusafuka K, Nakaguro M, Urano M, Taguchi KI, Yamamoto H, Kano S, Tada Y, Tsukahara K, Okami K, Onitsuka T, Fujimoto Y, Kawakita D, Sakurai K, Nagao T, Hanai N, Kawata R, Hato N, Otsuki N, Nibu KI, Inagaki H. Pathological evaluation of tumor grade for salivary adenoid cystic carcinoma: A proposal of an objective grading system. Cancer Sci. 2021 Mar;112(3):1184-1195.
    13. Ishikawa E, Nakaguro M, Nakamura M, Yamamura T, Sawada T, Mizutani Y, Maeda K, Furukawa K, Shimoyama Y, Kawashima H, Fujishiro M. Gastrointestinal tract metastasis of lung cancer: The PD-L1 expression and correlated clinicopathological variables. Pathol Int. 2021 Jan;71(1):33-41.
    14. Nakaguro M, Faquin WC, Baloch ZW, Cantley RL, Compton ML, Ely KA, Holmes BJ, Hu R, Kerr DA, Montone KT, Nishino M, Pantanowitz L, Rossi ED, Sadow PM. Fine needle aspiration of salivary gland carcinomas with high-grade transformation: A multi-institutional study of 22 cases and review of the literature. Cancer Cytopathol. 2021 Apr;129(4):318-325.
    15. Bishop JA, Nakaguro M, Whaley RD, Ogura K, Imai H, Laklouk I, Faquin WC, Sadow PM, Gagan J, Nagao T. Oncocytic Intraductal Carcinoma of Salivary Glands: A Distinct Variant with TRIM33-RET Fusions and BRAF V600E mutations. Histopathology. 2021 Sep;79(3):338-346.
    16. Bishop JA, Sajed DP, Weinreb I, Dickson BC, Bilodeau EA, Agaimy A, Franchi A, Khurram SA, Da Forno P, Robledo J, Kalmar JR, Aguirre S, Krane JF, Tapia JL, Kiss K, Cordell K, Rosebush M, Barrett AW, Oda D, Assaad A, Nagao T, Kawakami F, Nakaguro M, Zahir I, Wakeman K, Ihrler S, Chenevert J, Lin YL, Westra WH, Gagan J, Rooper LM. Microsecretory Adenocarcinoma of Salivary Glands: An Expanded Series of 24 Cases. Head Neck Pathol. 2021 Dec;15(4):1192-1201.
  • 2020年
    1. Kawakita D, Murase T, Ueda K, Kano S, Tada Y, Tsukahara K, Okami K, Onitsuka T, Fujimoto Y, Matoba T, Sakurai K, Nagao T, Hanai N, Kawata R, Hato N, Nibu KI, Urano M, Taguchi KI, Nakaguro M, Kusafuka K, Yamamoto H, Nagao T, Inagaki H.The impact of clinicopathological factors on clinical outcomes in patients with salivary gland adenoid cystic carcinoma: a multi-institutional analysis in Japan. Int J Clin Oncol. 2020 Oct;25(10):1774-1785.
    2. Nakata R, Uehara T, Iwaya M, Asaka S, Kobayashi S, Sugano M, Higuchi K, Kusama Y, Nakazawa K, Nakaguro M, Kobayashi M, Tateishi A, Makino M, Kawaguchi K, Maejima T, Ishii K, Sano K, Shimojo H, Hori A, Otsuki T, Hamano H, Kawa S, Ota H.Immunostaining With Immunoglobulin G Subclass Antibody Cocktail for Diagnosis of Type 1 Autoimmune Pancreatitis. Int J Surg Pathol. 2020 Dec;28(8):844-849.
    3. Nakaguro M, Tada Y, Faquin WC, Sadow PM, Wirth LJ, Nagao T.Salivary duct carcinoma: Updates in histology, cytology, molecular biology, and treatment. Cancer Cytopathol. 2020 Oct;128(10):693-703.
    4. Kitano A, Nakaguro M, Tomotaki S, Hanaoka S, Kawai M, Saito A, Hayakawa M, Takahashi Y, Kawasaki H, Yamada T, Ikeda M, Onda T, Cho K, Haga H, Nakazawa A, Minamiguchi S.A familial case of alveolar capillary dysplasia with misalignment of the pulmonary veins: the clinicopathological features and unusual glomeruloid endothelial proliferation. Diagn Pathol. 2020 May 9;15(1):48.
    5. Tsuboi T, Harada Y, Suzuki M, Ando T, Atsuta N, Ohka F, Takeuchi K, Taoka T, Ohba S, Nakaguro M, Abe M, Nakashima I, Yoshida M, Katsuno M.Steroid-responsive recurrent tumefactive demyelination with multiple petechial hemorrhages along non-displaced medullary veins. Clin Neurol Neurosurg. 2020 Jun;193:105764.
    6. Hirai H, Tada Y, Nakaguro M, Kawakita D, Sato Y, Shimura T, Tsukahara K, Kano S, Ozawa H, Okami K, Sato Y, Fushimi C, Shimizu A, Okamoto I, Takase S, Okada T, Sato H, Imanishi Y, Otsuka K, Watanabe Y, Sakai A, Ebisumoto K, Togashi T, Ueki Y, Ota H, Saigusa N, Takahashi H, Ando M, Urano M, Hanazawa T, Nagao T.The clinicopathological significance of the adipophilin and fatty acid synthase expression in salivary duct carcinoma. Virchows Arch. 2020 Aug;477(2):291-299.
    7. Higuchi K, Urano M, Nakaguro M.Enhanced performance of the Milan System for Reporting Salivary Gland Cytopathology: Point of view from an Asian country. Cancer Cytopathol. 2020 May;128(5):305-306.2020;128(5):305‐306.
    8. Ueda K, Murase T, Nagao T, Kusafuka K, Urano M, Yamamoto H, Nakaguro M, Taguchi KI, Masaki A, Hirai H, Kawakita D,Tsukahara K, Hato N, Nagao T, Fujimoto Y, Sakurai K, Hanai N, Kano S, Onitsuka T, Okami K, Nibu KI, Tada Y, Kawata R, Inagaki H. Central pathology review of salivary gland adenoid cystic carcinoma. Head Neck. 2020 Aug;42(8):1721-1727
    9. Yamaguchi S, Sawamura A, Nakaguro M, Shimoyama Y, Morimoto R, Kato H, Arao Y, Oishi H, Haga T, Kuwayama T, Yokoi T, Hiraiwa H, Kondo T, Okumura T, Murohara T. Giant cell myocarditis with central diabetes insipidus: A case report. J Cardiol Cases. 2019 Sep 10;21(1):8-11. doi: 10.1016/j.jccase.2019.08.011. eCollection 2020 Jan. PMID: 31933698 Free PMC article.
    10. Kohno K, Sakakibara A, Iwakoshi A, Hasegawa M, Adachi S, Ishikawa E, Suzuki Y, Shimada S, Nakaguro M, Shimoyama Y, Takahara T, Takahashi E, Ohashi A, Satou A, Kato S, Asano N, Nakamura S. Syncytial variant of classic Hodgkin lymphoma: Four cases diagnosed with the aid of CD274/programmed cell death ligand 1 immunohistochemistry. Pathol Int. 2020 Feb;70(2):108-115.
    11. Sakakibara A, Kohno K, Iwakoshi A, Moritani S, Fujishiro A, Kito K, Suzuki Y, Shimada S, Nakaguro M, Shimoyama Y, Takahara T, Takahashi E, Ohashi A, Satou A, Kato S, Asano N, Nakamura S. Diagnostic utility of programmed cell death ligand 1 (clone SP142) in mediastinal composite lymphoma: A report of two cases. Pathol Int. 2020 Feb;70(2):116-122.
    12. Nakaguro M, Sato Y, Tada Y, Kawakita D, Hirai H, Urano M, Shimura T, Tsukahara K, Kano S, Ozawa H, Okami K, Sato Y, Fushimi C, Shimizu A, Takase S, Okada T, Sato H, Imanishi Y, Otsuka K, Watanabe Y, Sakai A, Ebisumoto K, Togashi T, Ueki Y, Ota H, Saigusa N, Takahashi H, Ando M, Hanazawa T, Nagao T. Prognostic Implication of Histopathologic Indicators in Salivary Duct Carcinoma: Proposal of a Novel Histologic Risk Stratification Model. Am J Surg Pathol. 2020 Apr;44(4):526-535.
    13. Mikubo M, Seto K, Kitamura A, Nakaguro M, Hattori Y, Maeda N, Miyazaki T, Watanabe K, Murakami H, Tsukamoto T, Yamada T, Fujita S, Masago K, Ramkissoon S, Ross JS, Elvin J, Yatabe Y. Calculating the Tumor Nuclei Content for Comprehensive Cancer Panel Testing. J Thorac Oncol. 2020 Jan;15(1):130-137.
    14. Nakaguro M, Urano M, Ogawa I, Hirai H, Yamamoto Y, Yamaguchi H, Tanigawa M, Matsubayashi J, Hirano H, Shibahara J, Tada Y, Tsuzuki T, Okada Y, Sato Y, Ikeda K, Sukeda A, Honda Y, Mikami Y, Nagao T. Histopathological evaluation of minor salivary gland papillary-cystic tumours: focus on genetic alterations in sialadenoma papilliferum and intraductal papillary mucinous neoplasm. Histopathology. 2020 Feb;76(3):411-422.
    15. Kobayashi K, Miyahara R, Funasaka K, Furukawa K, Sawada T, Maeda K, Yamamura T, Ishikawa T, Ohno E, Nakamura M, Kawashima H, Nakaguro M, Okumura Y, Hirooka Y, Fujishiro M. Color information from linked color imaging is associated with invasion depth and vascular diameter in superficial esophageal squamous cell carcinoma. Dig Endosc. 2020 Jan;32(1):65-73.
    16. Maeda O, Ohka F, Maesawa S, Matsuoka A, Shimokata T, Mitsuma A, Urakawa H, Nakamura S, Shimoyama Y, Nakaguro M, Wakabayashi T, Ando Y. Solitary fibrous tumor/hemangiopericytoma treated with temozolomide plus bevacizumab: a report of four cases and literature review. Nagoya J Med Sci. 2020;82(4):631-644.
    17. Kawakami F, Nagao T, Honda Y, Sakata J, Yoshida R, Nakayama H, Inoue S, Kitajima M, Ikeda O, Nakaguro M, Mikami Y. Microsecretory adenocarcinoma of the hard palate: A case report of a recently described entity. Pathol Int. 2020 Oct;70(10):781-785.
  • 2019年
    1. Matsuhisa T, Takahashi N, Nakaguro M, Sato M, Inoue E, Teshigawara S, Ozawa Y, Kondo T, Nakamura S, Sato J, Ban N. Fatal case of TAFRO syndrome associated with over-immunosuppression: a case report and review of the literature. Nagoya J Med Sci. 2019 Aug;81(3):519-528. doi: 10.18999/nagjms.81.3.519. PMID: 31579342 Free PMC article. Revie
    2. Okumura J, Nakahara Y, Nakaguro M, Shindo Y, Hase T, Wakahara K, Hashimoto N, Hasegawa Y. BK virus-associated viruria and viremia in a patient with lymphangioleiomyomatosis after lung re-transplantation: A case report and review of the literature on BK virus infection post-lung transplantation. J Infect Chemother. 2019 Oct;25(10):820-824. doi: 10.1016/j.jiac.2019.04.002. Epub 2019 Apr 23. PMID: 31027885 Review.
    3. Urano M, Nakaguro M, Yamamoto Y, Hirai H, Tanigawa M, Saigusa N, Shimizu A, Tsukahara K, Tada Y, Sakurai K, Isomura M, Okumura Y, Yamaguchi H, Matsubayashi J, Nagao T. Diagnostic Significance of HRAS Mutations in Epithelial-Myoepithelial Carcinomas Exhibiting a Broad Histopathologic Spectrum. Am J Surg Pathol. 2019 Jul;43(7):984-994. doi: 10.1097/PAS.0000000000001258. PMID: 30994537
    4. Fujiyoshi T, Miyahara R, Funasaka K, Furukawa K, Sawada T, Maeda K, Yamamura T, Ishikawa T, Ohno E, Nakamura M, Kawashima H, Nakaguro M, Nakatochi M, Hirooka Y. Utility of linked color imaging for endoscopic diagnosis of early gastric cancer. World J Gastroenterol. 2019 Mar 14;25(10):1248-1258. doi: 10.3748/wjg.v25.i10.1248. PMID: 30886507 Free PMC article.
    5. Ogawa H, Takehara Y, Naganawa S, Yamaguchi J, Nakaguro M. A case of human pancreatic eurytremiasis. Abdom Radiol (NY). 2019 Apr;44(4):1213-1216. doi: 10.1007/s00261-019-01925-4. PMID: 30758533
    6. Shinohara K, Ebata T, Shimoyama Y, Nakaguro M, Mizuno T, Matsuo K, Nagino M. Proposal for a new classification for perihilar cholangiocarcinoma based on tumour depth. Br J Surg. 2019 Mar;106(4):427-435. doi: 10.1002/bjs.11063. Epub 2019 Jan 24. PMID: 30675908
    7. Ogawa-Momohara M, Muro Y, Nakaguro M, Takeichi T, Kono M, Akiyama M. Acrodermatitis continua of Hallopeau with dense infiltration of IgG4-positive cells in the lesional dermis. Br J Dermatol. 2019 Apr;180(4):941-942. doi: 10.1111/bjd.17405. Epub 2018 Dec 27. PMID: 30411319 No abstract available.
  • 2018年
    1. Urano M, Hirai H, Tada Y, Kawakita D, Shimura T, Tsukahara K, Kano S, Ozawa H, Okami K, Sato Y, Fushimi C, Shimizu A, Takase S, Okada T, Sato H, Imanishi Y, Otsuka K, Watanabe Y, Sakai A, Ebisumoto K, Togashi T, Ueki Y, Ota H, Sato Y, Saigusa N, Nakaguro M, Hanazawa T, Nagao T. The high expression of FOXA1 is correlated with a favourable prognosis in salivary duct carcinomas: a study of 142 cases. Histopathology. 2018 Dec;73(6):943-952. doi: 10.1111/his.13706. Epub 2018 Sep 25. PMID: 29993139
    2. Yamaguchi S, Morimoto R, Okumura T, Yamashita Y, Haga T, Kuwayama T, Yokoi T, Hiraiwa H, Kondo T, Sugiura Y, Watanabe N, Kano N, Kohno K, Fukaya K, Sawamura A, Yokota K, Ishii H, Nakaguro M, Akiyama M, Murohara T. Late-Onset Fulminant Myocarditis With Immune Checkpoint Inhibitor Nivolumab. Can J Cardiol. 2018 Jun;34(6):812.e1-812.e3. doi: 10.1016/j.cjca.2018.03.007. Epub 2018 Mar 20. PMID: 29801747
    3. Suzuki Y, Ichihara S, Kawasaki T, Yanai H, Kitagawa S, Shimoyama Y, Nakamura S, Nakaguro M. β-catenin (CTNNB1) mutation and LEF1 expression in sinonasal glomangiopericytoma (sinonasal-type hemangiopericytoma). Virchows Arch. 2018 Aug;473(2):235-239. doi: 10.1007/s00428-018-2370-9. Epub 2018 May 7. PMID: 29736797
    4. Nakaguro M, Urano M, Suzuki H, Yamada K, Sakaguchi A, Ogura K, Matsumoto T, Ono N, Asato T, Mikami Y, Imai H, Nagao T. Low-grade intraductal carcinoma of the salivary gland with prominent oncocytic change: a newly described variant. Histopathology. 2018 Aug;73(2):314-320. doi: 10.1111/his.13517. Epub 2018 May 21. PMID: 29574881
    5. Kinugawa Y, Uehara T, Matsuda K, Kobayashi Y, Nakajima T, Hamano H, Kawa S, Higuchi K, Hosaka N, Shiozawa S, Ishigame H, Nakamura T, Maruyama Y, Nakazawa K, Nakaguro M, Sano K, Ota H. Promoter hypomethylation of SKI in autoimmune pancreatitis. Pathol Res Pract. 2018 Apr;214(4):492-497. doi: 10.1016/j.prp.2018.03.005. Epub 2018 Mar 6. PMID: 29534839
    6. Sakakibara A, Kohno K, Kuroda N, Yorita K, Megahed NA, Eladl AE, Daroontum T, Ishikawa E, Suzuki Y, Shimada S, Nakaguro M, Shimoyama Y, Satou A, Kato S, Yatabe Y, Asano N, Nakamura S. Anaplastic variant of diffuse large B-cell lymphoma with hallmark cell appearance: Two cases highlighting a broad diversity in the diagnostics. Pathol Int. 2018 Apr;68(4):251-255. doi: 10.1111/pin.12653. Epub 2018 Feb 25. PMID: 29479776
    7. Sakakibara A, Kohno K, Eladl AE, Klaisuwan T, Ishikawa E, Suzuki Y, Shimada S, Nakaguro M, Shimoyama Y, Takahara T, Kato S, Asano N, Nakamura S, Satou A. Immunohistochemical assessment of the diagnostic utility of PD-L1: a preliminary analysis of anti-PD-L1 antibody (SP142) for lymphoproliferative diseases with tumour and non-malignant Hodgkin-Reed-Sternberg (HRS)-like cells. Histopathology. 2018 Jun;72(7):1156-1163. doi: 10.1111/his.13475. Epub 2018 Mar 9. PMID: 29380399
  • 2017年
    1. Tsurudome I, Miyahara R, Funasaka K, Furukawa K, Matsushita M, Yamamura T, Ishikawa T, Ohno E, Nakamura M, Kawashima H, Watanabe O, Nakaguro M, Satou A, Hirooka Y, Goto H. In vivo histological diagnosis for gastric cancer using endocytoscopy.
    2. World J Gastroenterol. 2017 Oct 7;23(37):6894-6901. doi: 10.3748/wjg.v23.i37.6894. PMID: 29085232 Free PMC article.
    3. Shinohara K, Shimoyama Y, Ebata T, Yokoyama Y, Mizuno T, Nakaguro M, Nagino M. Clinicopathologic study on metachronous double cholangiocarcinomas of perihilar and subsequent distal bile duct origin. Surgery. 2017 Jul;162(1):84-93. doi:10.1016/j.surg.2016.12.034. Epub 2017 Feb 7. PMID: 28187867
  • 2016年
    1. Chantarojanasiri T, Hirooka Y, Kawashima H, Ohno E, Yamamura T, Funasaka K, Nakamura M, Miyahara R, Ishigami M, Watanabe O, Nakaguro M, Shimoyama Y, Nakamura S, Goto H. Endoscopic ultrasound in the diagnosis of acinar cell carcinoma of the pancreas: contrast-enhanced endoscopic ultrasound, endoscopic ultrasound elastography, and pathological correlation. Endosc Int Open. 2016 Nov;4(11):E1223-E1226. doi: 10.1055/s-0042-110096. Epub 2016 Nov 10. PMID: 27853750 Free PMC article.
    2. Nakaguro M, Tsuzuki T, Shimada S, Taki T, Tsuchiyama M, Kitamura A, Suzuki Y, Nakano Y, Ono K. Adenocarcinoma arising in urinary bladder endocervicosis. Pathol Int. 2016 Feb;66(2):108-13. doi: 10.1111/pin.12375. Epub 2016 Jan 13. PMID: 26762595
    3. Tanaka T, Yamamoto H, Elsayed AA, Satou A, Asano N, Kohno K, Kinoshita T, Niwa Y, Goto H, Nakamura S, Kato S. Clinicopathologic Spectrum of Gastrointestinal T-cell Lymphoma: Reappraisal Based on T-cell Receptor Immunophenotypes. The American Journal of Surgical Pathology, 2016; 40: 777-785. Satou A, Asano N, Kato S, Katsuya H, Ishitsuka K, Elsayed AA, Nakamura S. FoxP3-positive T cell lymphoma arising in non-HTLV1 carrier: clinicopathological analysis of 11 cases of PTCL-NOS and 2 cases of mycosis fungoides. Histopathology, 2016; 68: 1099-1108.
  • 2015年
    1. Satou A, Asano N, Nakazawa A, Osumi T, Tsurusawa M, Ishiguro A, Elsayed AA, Nakamura N, Ohshima K, Kinoshita T, Nakamura S. Epstein-Barr Virus (EBV)-positive Sporadic Burkitt Lymphoma: An Age-related Lymphoproliferative Disorder? The American Journal of Surgical Pathology, 2015; 39: 227-235.
    2. Kato S, Asano N, Miyata-Takata T, Takata K, Elsayed AA, Satou A, Takahashi E, Kinoshita T, Nakamura S. T-cell Receptor (TCR) Phenotype of Nodal Epstein-Barr Virus (EBV)-positive Cytotoxic T-cell Lymphoma (CTL): A Clinicopathologic Study of 39 Cases. The American Journal of Surgical Pathology, 2015; 39: 462-471.
    3. Nakaguro M, Kiyonari S, Kishida S, Cao D, Murakami-Tonami Y, Ichikawa H, Takeuchi I, Nakamura S, Kadomatsu K. Nucleolar protein PES1 is a marker of neuroblastoma outcome and is associated with neuroblastoma differentiation. Cancer Sci. 2015 Mar;106(3):237-43. doi: 10.1111/cas.12598. Epub 2015 Feb 4. PMID: 25557119 Free PMC article.
  • 2014年
    1. Adachi S, Hirashiki A, Kondo T, Nakaguro M, Ogawa A, Miyaji K, Matsubara H, Yokoi T, Murohara T. Imatinib is partially effective for the treatment of pulmonary capillary hemangiomatosis. Intern Med. 2014;53(6):603-7. doi: 10.2169/internalmedicine.53.1157. PMID: 24633031
  • 2012年
    1. Liu F, Asano N, Tatematsu A, Oyama T, Kitamura K, Suzuki K, Yamamoto K, Sakamoto N, Taniwaki M, Kinoshita T, Nakamura S. Plasmablastic lymphoma of the elderly: a clinicopathological comparison with age-related Epstein–Barr virus-associated B cell lymphoproliferative disorder. Histopathology, 2012; 61: 1183-1197.
    2. Kimura H, Ito Y, Kawabe S, Gotoh K, Takahashi Y, Kojima S, Naoe T, Esaki S, Kikuta A, Sawada A, Kawa K, Ohshima K, Nakamura S. EBV-associated T/NK-cell lymphoproliferative diseases in nonimmunocompromised hosts: prospective analysis of 108 cases. Blood, 2012; 119: 673-686.
    3. Kato S, Takahashi E, Asano N, Tanaka T, Megahed N, Kinoshita T, Nakamura S. Nodal cytotoxic molecule (CM)-positive Epstein-Barr virus (EBV)-associated peripheral T cell lymphoma (PTCL): a clinicopathological study of 26 cases. Histopathology, 2012; 61: 186-199.
  • 2011年
    1. Huang P, Kishida S, Cao D, Murakami-Tonami Y, Mu P, Nakaguro M, Koide N, Takeuchi I, Onishi A, Kadomatsu K. The neuronal differentiation factor NeuroD1 downregulates the neuronal repellent factor Slit2 expression and promotes cell motility and tumor formation of neuroblastoma. Cancer Res. 2011 Apr 15;71(8):2938-48. doi: 10.1158/0008-5472.CAN-10-3524. Epub 2011 Feb 24. PMID: 21349947
    2. Takahashi E, Ohshima K, Kimura H, Hara K, Suzuki R, Kawa K, Eimoto T, Nakamura S. Clinicopathological analysis of the age-related differences in patients with Epstein-Barr virus (EBV)-associated extranasal natural killer (NK)/T-cell lymphoma with reference to the relationship with aggressive NK cell leukaemia and chronic active EBV infection-associated lymphoproliferative disorders. Histopathology, 2011; 59: 660-671.
    3. Asano N, Kinoshita T, Tamaru J-I, Ohshima K, Yoshino T, Niitsu N, Tsukamoto N, Hirabayashi K, Izutsu K, Taniwaki M, Morishima Y, Nakamura S. Cytotoxic molecule-positive classical Hodgkin’s lymphoma: a clinicopathological comparison with cytotoxic molecule-positive peripheral T-cell lymphoma of not otherwise specified type. Haematologica, 2011; 96: 1636-1643.
  • 2009年
    1. Asano N, Yamamoto K, Tamaru J-I, Oyama T, Ishida F, Ohshima K, Yoshino T, Nakamura N, Mori S, Yoshie O, Shimoyama Y, Morishima Y, Kinoshita T, Nakamura S. Age-related Epstein-Barr virus (EBV)–associated B-cell lymphoproliferative disorders: comparison with EBV-positive classic Hodgkin lymphoma in elderly patients. Blood, 2009; 113: 2629-2636.
  • 2007年
    1. Oyama T, Yamamoto K, Asano N, Oshiro A, Suzuki R, Kagami Y, Morishima Y, Takeuchi K, Izumo T, Mori S, Ohshima K, Suzumiya J, Nakamura N, Abe M, Ichimura K, Sato Y, Yoshino T, Naoe T, Shimoyama Y, Kamiya Y, Kinoshita T, Nakamura S. Age-related EBV-associated B-cell lymphoproliferative disorders constitute a distinct clinicopathologic group: a study of 96 patients. Clin Cancer Res, 2007; 13: 5124-5132.
    2. Ponzoni M, Ferreri AJM, Campo E, Facchetti F, Mazzucchelli L, Yoshino T, Murase T, Pileri SA, Doglioni C, Zucca E, Cavalli F, Nakamura S. Definition, Diagnosis, and Management of Intravascular Large B-Cell Lymphoma: Proposals and Perspectives From an International Consensus Meeting. J Clin Oncol, 2007; 25: 3168-3173.
    3. Murase T, Yamaguchi M, Suzuki R, Okamoto M, Sato Y, Tamaru J-i, Kojima M, Miura I, Mori N, Yoshino T, Nakamura S. Intravascular large B-cell lymphoma (IVLBCL): a clinicopathologic study of 96 cases with special reference to the immunophenotypic heterogeneity of CD5. Blood, 2007; 109: 478-485.
  • 2006年
    1. Asano N, Oshiro A, Matsuo K, Kagami Y, Ishida F, Suzuki R, Kinoshita T, Shimoyama Y, Tamaru J-I, Yoshino T, Kitamura K, Fukutani H, Morishima Y, Nakamura S. Prognostic Significance of T-Cell or Cytotoxic Molecules Phenotype in Classical Hodgkin’s Lymphoma: A Clinicopathologic Study. J Clin Oncol, 2006; 24: 4626-4633.

研究キーワード

外科病理学、検査医学、分子診断、悪性リンパ腫、EBウイルス、細胞傷害性分子、T細胞受容体、唾液腺病理

その他

大学院生（博士課程）を募集しています。

病理診断の質の向上、ひいてはさまざまな病気の解明につながることを目的として、主に病理検体を用いた研究を行っています。専門医資格を取得した後に入学するのでもいいですし、大学院の研究と専門医研修を同時に進めることもできます。ぜひ気軽に教室見学に来てください。進路や教室見学について随時相談に応じます。まずは下記までメールでご連絡ください。

連絡先：加留部謙之輔（かるべ　けんのすけ）　　mail：karube＠med.nagoya-u.ac.jp　または　temi＠med.nagoya-u.ac.jp　　TEL：052-744-2896