研究室紹介Laboratories

Back
Top > 研究室紹介 > 頭頸部・感覚器外科学 > 顎顔面外科学

頭頸部・感覚器外科学顎顔面外科学

概要

昭和41年に口腔外科学講座が開設されてから50年がたち、その前身の診療科時代を含めれば約100年の歴史があります。先人たちの地道な努力のおかげで環境、人材ともに恵まれ、学内に約50名、学外の関連施設にも約50名が研究に、臨床に切磋琢磨しています。おもな研究内容は悪性腫瘍、再生医療などに関するものであり、その成果は質、量とも一定の評価を得ています。とくに再生医療の分野では基礎から臨床までをつなげる、いわゆるトランスレーショナルリサーチや先進医療、産業化の実績があります。

研究プロジェクト

再生医療

i) 培養細胞による組織再生

失ったからだの一部をなおすには他の部位からとってきた組織を移植する必要がありますが、これはたいへんなことでした。そこでそれにかわるものとして再生医療が注目されています。これはからだの中からほんのすこしの細胞を取り出し、からだの外で培養して増やしてから、またからだに戻し必要な組織をつくらせるというものです。当講座には粘膜・皮膚や骨の欠損、脊髄損傷などの研究で実績があります。皮膚では企業への技術移転、骨では先進医療として実施がかないました。先進医療B「骨髄由来間葉系細胞による顎骨再生療法」は自分のからだから取り出した骨髄の細胞と血液成分を組み合わせて骨を再生させるものであり、全国で唯一の厚生労働省承認医療機関として実施しました。

ii) 幹細胞由来エクソソームによる組織修復、再生療法の開発

oral_surgery_figure.pngヒトの体には不完全ながら修復・再生能力が備わっています。例えば,皮膚損傷や骨折などでは自らの治癒能力を駆使して組織修復を行っています。しかしながら、一旦失った組織や臓器が修復・再生されることはほとんどありません。歯科領域においても、難病にも指定されている自己免疫疾患は多数あり、慢性化した病態であり修復・再生不可能な組織であるとされています。私たちはこれまでの研究で、損傷した組織で重要な役割を果たすと考えられる幹細胞由来エクソソームに含まれるいくつかのmicro RNA (miRNA)を同定しました。それらのmiRNAは組織が損傷していく過程で幹細胞の老化抑制,損傷細胞の生存率促進に関与し、幹細胞の“若返り”に関わっている可能性があると考えています。今後は内在性の幹細胞やその微少環境にある細胞を修復・再生することを解析する予定です。

教員

構成員名役職所属
日比 英晴 教授 医学系研究科頭頸部感覚器外科学講座 顎顔面外科学
藤尾 正人 講師 医学部附属病院 歯科口腔外科
酒井 陽 助教 医学部附属病院 歯科口腔外科
山口 聡 助教 医学系研究科頭頸部感覚器外科学講座 顎顔面外科学
市村 典久 助教 医学系研究科頭頸部感覚器外科学講座 顎顔面外科学
佐藤 康太郎 助教 医学系研究科頭頸部感覚器外科学講座 顎顔面外科学
坂口 晃平 助教 医学部附属病院 歯科口腔外科
佐世 暁 助教 医学部附属病院 歯科口腔外科
渡邊 純奈 病院助教 医学部附属病院 歯科口腔外科

研究実績

  • 2024年
    1. Ichimura N, Urata Y, Kobayashi T, Hibi H. Mutational landscape of oral mucosal melanoma based on comprehensive cancer genomic profiling tests in a Japanese cohort. Oral Oncol, 2024; 152: 106807.
    2. Liu K, Sakai K, Watanabe J, Dong J, Maruyama H, Li X, Hibi H. Conditioned medium of human mesenchymal stem cells affects stem cell senescence in osteoporosis. Biochem Biophys Res Commun, 2024; 711: 149858.
    3. Chen H, Yamaguchi S, Wang Y, Kaminogo K, Sakai K, Hibi H. Cytoprotective role of human dental pulp stem cell-conditioned medium in chemotherapy-induced alopecia. Stem Cell Res Ther, 2024; 15(1): 84.
    4. Kaminogo K, Yamaguchi S, Tokura T, Kimura H, Kishi S, Ichimura N, Yamamoto N, Ohara G, Chen H, Ozaki N, Ikeda M, Hibi H. Predictors of anxiety and depression in patients with oral cancer undergoing radical resection with reconstructive surgery. Oral Oncol Rep, 2024; 10: 100295. 

    5. Okamoto M, Nakashima H, Sakai K, Takegami Y, Osawa Y, Watanabe J, Ito S, Hibi H, Imagama S. Cellular senescence is associated with osteonecrosis of the femoral head while mesenchymal stem cell conditioned medium inhibits bone collapse. Sci Rep, 2024; 14(1): 3329.
    6. Ohara G, Okabe K, Toyama N, Ohta Y, Song X, Tsuboi M, Kouyama N, Sato K, Hibi H. Stem cell therapy based on human periodontal ligament stem cells preactivated with TNF-α as for human head and neck squamous cell carcinoma. J Oral Maxillofac Surg Med Pathol, 2024; 36(2): 217-226.
  • 2023年
    1. Sato K, Yang M, Nakamura K, Tanaka H, Hori M, Nishio M, Suzuki A, Hibi H, Toyokuni S. Ferroptosis induced by plasma-activated Ringer’s lactate solution prevents oral cancer progression. Oral Diseases, 2023
    2. Yamaguchi S, Toyama N, Kaminogo K, Ohara G, Ichimura N, Kouyama N, Kamei Y, Hibi H. Preoperative controlling nutritional status (CONUT) is a predictor of short-term outcomes in patients with oral cancer. Oral Oncol Rep, 2023; 8: 100119.
    3. Ohara G, Okabe K, Toyama N, Ohta Y, Song X, Ichimura N, Sato K, Urata Y, Hibi H. Hyperthermia maintains death receptor expression and promotes TRAIL-induced apoptosis. J Oral Pathol Med, 2023; 52(8): 718-726.
    4. Shimane T, Koike K, Fujita S, Kurita H, Isomura ET, Chikazu D, Kanno N, Sasaki K, Hino S, Hibi H, Koyama T, Nakamura S, Nomura T, Mori Y, Tojyo I, Yamamoto T, Yamamori I, Aota K, Tanzawa H. Positive impact of perioperative oral management on the risk of surgical site infections after abdominal surgery: Sixteen universities in Japan. Medicine (Baltimore), 2023; 102(37): e35066.
    5. Chang Q, Fujio M, Tsuboi M, Bian H, Wakasugi M, Hibi H. High-mobility group box 1 accelerates distraction osteogenesis healing via the recruitment of endogenous stem/progenitor cells. Cytotherapy, 2023; 25(9): 946 - 955.
    6. Yamaguchi S, Kaminogo K, Tokura T, Kimura H, Kishi S, Yamamoto N, Ichimura N, Ozaki N, Hibi H. Postoperative social adaptation in correlation with the number of supporters for patients with oral cancer. Oral Oncol Rep, 2023; 6: 100054.
    7. Imura M, Sato K, Okabe K, Hibi H. Mandible fracture treated with the SMARTLock hybrid maxillomandibular fixation system: A case report. Oral Sci Jpn, 2023; 2022: 9-11.
    8. Sato K, Fujii K, Tanaka H, Hori M, Hibi H, Toyokuni S. Exposure of low-temperature plasma after vaccination in tongue promotes systemic IgM induction against spike protein of SARS-CoV-2. Free Radic Res, 2023; 57: 30-37.
    9. Song X, Okabe K, Ohta Y, Ohara G, Toyama N, Chang Q, Wang Y, Hibi H. Family with sequence similarity 20 member B regulates osteogenic differentiation of bone marrow mesenchymal stem cells on titanium surfaces. Acta Biomater, 2023; 161: 298-308.
    10. Kaminogo K, Yamaguchi S, Tokura T, Kimura H, Kishi S, Yamamoto N, Ozaki N, Hibi H. Coping styles and quality of life in oral cancer patients undergoing radical resection and free flap reconstruction. Oral Oncol Rep,2023; 5: 100015.
    11. Fujio M, Sayo A, Ogisu K, Chang Q, Tsuboi M, Hibi H. Comparison study of the Le Fort I osteotomy using 2- and 4-plate fixation. Nagoya J Med Sci,2023; 85(1): 70-78.
    12. Yamaguchi S, Kaminogo K, Tokura T, Kimura H, Kishi S, Yamamoto N, Ichimura N, Koma Y, Ozaki N, Hibi H. Social adaptation following radical resection and free flap reconstruction for oral cancer. Adv Oral Maxillofac Surg,2023; 10:100416.
    13. Kano F, Hashimoto N, Liu Y, Xia L, Nishihara T, Oki W, Kawarabayashi K, Mizusawa N, Aota K, Sakai T, Azuma M, Hibi H, Iwasaki T, Iwamoto T, Horimai N, Yamamoto A. Therapeutic benefits of factors derived from stem cells from human exfoliated deciduous teeth for radiation-induced mouse xerostomia. Sci Rep, 2023; 13(1): 2706.
    14. Ichimura N, Yamamoto N, Urata Y, Ikutomi S, Hibi H. A case of sternal osteomyelitis caused by defective wound healing after surgery of gingival cancer. IDCases, 2023; 31: e01682.
    15. Sakai K, Yamamoto N, Yamaguchi S, Okabe K, Koma Y, Hibi H. Langerhans cell histiocytosis of single-system multifocal bone, including the mandible, in a 22-month-old child: A case report. Oral Sci Int, 2023; 20(1): 60-64.
  • 2022年
    1. Yamaguchi S, Kaminogo K, Tokura T, Kimura H, Kishi S, Yamamoto N, Ichimura N, Toyama N, Koma Y, Kouyama N, Ozaki N, Hibi H. Psychological impact on patients with oral cancer before undergoing resection and free flap reconstruction surgery. Oral Oncol Rep, 2022; 3-4: 100004.
    2. Sato K, Fujii K, Yamamoto N, Ichimura N, Yamaguchi S, Yamada H, Hibi H, Toyokuni S. Association of alcohol intake and female gender with high expression of TMPRSS2 in tongue as potential risk for SARS-CoV-2 infection. J Clin Biochem Nutr, 2022; 71(2): 129-135.
    3. Sakaguchi K, Taguchi N, Kobayashi R, Taguchi K, Okada K, Kinoshita F, Hibi H. Immediate curative effects of exercise therapy in patients with myalgia of the masticatory muscles. J Oral Rehabil, 2022; 49(10): 937-943.
    4. Okabe K, Kaneko R, Kawai T, Ohta Y, Ohara G, Hibi H. Efficacy of semi-solidification of enteral nutrients for postoperative nutritional management with a nasogastric tube. Nagoya J Med Sci,2022; 84(2): 366-373.
    5. Koma Y, Fujimoto T, Sakai K, Sugimura Y, Yamaguchi S, Hibi H. Coexistence of Sjögren’s syndrome and bilateral ranulas: A case report and review of the literature. Oral Sci Int, 2022; 19(2): 111-116.
    6. Liu Y, Kano F, Hashimoto N, Xia L, Zhou Q, Feng X, Hibi H, Miyazaki A, Iwamoto T, Matsuka Y, Zhang Z, Tanaka E, Yamamoto A, Conditioned Medium From the Stem Cells of Human Exfoliated Deciduous Teeth Ameliorates Neuropathic Pain in a Partial Sciatic Nerve Ligation Model. Front Pharmacol, 2022; 13: 745020.
    7. Ichimura N, Fujio M, Toyama N, Yamada H, Hibi H. A case of temporomandibular joint herniation. J Oral Maxillofac Surg Med Pathol, 2022; 34(2): 174-177.
    8. Yamada H, Ichimura N, Yamamoto N, Okumura Y, Nishikawa M, Yamaguchi S, Uejima S, Hibi H. A case of low-grade mucoepidermoid carcinoma with bone invasion of the mandible arising from the sublingual gland showing a MAML2 Gene Split. J Oral Maxillofac Surg Med Pathol, 2022; 34(2): 164-168.
    9. Yamamoto N, Yamaguchi S, Nishikawa M, Ichimura N, Ohara G, Hibi H. Aneurysm of the lingual artery in a patient with fibromuscular dysplasia: A case report. J Oral Maxillofac Surg Med Pathol, 2022; 34(1): 45-48.
  • 2021年
    1. Iwama S, Kobayashi T, Yasuda Y, Okuji T, Ito M, Ando M, Zhou X, Yamagami A, Onoue T, Kawaguchi Y, Miyata T, Sugiyama M, Takagi H, Hagiwara D, Suga H, Banno R, Hase T, Morise M, Wakahara K, Yokota K, Kato M, Nishio N, Tanaka C, Miyata K, Ogura A, Ito T, Sawada T, Shimokata T, Niimi K, Ohka F, Ishigami M, Gotoh M, Hashimoto N, Saito R, Kiyoi H, Kajiyama H, Ando Y, Hibi H, Sone M, Akiyama M, Kodera Y, Arima H. Increased risk of thyroid dysfunction by PD-1 and CTLA-4 blockade in patients without thyroid autoantibodies at baseline. J Clin Endocrinol Metab, 2021; 15: dgab829.
    2. Ichimura N, Yamamoto N, Toyama N, Hibi H. A case of Maffucci syndrome with a buccal hemangioma harboring a mutation in IDH1. Oral Oncol, 2021; 122: 105553.
    3. Dong J, Sakai K, Koma Y, Watanabe J, Liu K, Maruyama H, Sakaguchi K, Hibi H. Dental pulp stem cell-derived small extracellular vesicle in irradiation-induced senescence. Biochem Biophys Res Commun, 2021; 575: 28-35.
    4. Ito T, Ishigami M, Yamamoto T, Mizuno K, Yamamoto K, Imai N, Ishizu Y, Honda T, Kawashima H, Yasuda S, Toyoda H, Yokota K, Hase T, Nishio N, Maeda O, Kato M, Hashimoto N, Hibi H, Kodera Y, Sone M, Ando Y, Akiyama M, Shimoyama Y, Fujishiro M. Clinical course of liver injury induced by immune checkpoint inhibitors in patients with advanced malignancies. Hepatol Int, 2021; 15(5): 1278-1287.
    5. Muto H, Ito T, Tanaka T, Yokoyama S, Yamamoto K, Imai N, Ishizu Y, Maeda K, Honda T, Ishikawa T, Kato A, Ohshiro T, Kano F, Yamamoto A, Sakai K, Hibi H, Ishigami M, Fujishiro M. Conditioned medium from stem cells derived from human exfoliated deciduous teeth ameliorates NASH via the Gut-Liver axis. Sci Rep, 2021; 11: 18778.
    6. Yamaguchi S, Yamamoto N, Nishikawa M, Ichimura N, Sakai K, Koma Y, Hibi H. Hyperparathyroidism-jaw tumor syndrome with bilateral ossifying fibromas in the mandible: A case report. J Oral Maxillofac Surg Med Pathol, 2021; 33(4): 430-433.
    7. Sato K, Sharma KP, Terajima M, Musicant AM, Murphy RM, Ramsey MR, Hibi H, Yamauchi M, Amelio AL. Lysyl hydroxylase 2-induced collagen cross-link switching promotes metastasis in head and neck squamous cell carcinomas. Neoplasia, 2021; 23(6): 594–607.
    8. Terajima M, Taga Y, Brisson BK, Durham AC, Sato K, Uzawa K, Saito T, Hattori S, Sørenmo KU, Yamauchi M Volk SW. Collagen molecular phenotypic switch between non‑neoplastic and neoplastic canine mammary tissues. Sci rep, 2021; 11: 8659.
    9. Yamada SI, Koike K, Isomura ET, Chikazu D, Yamagata K, Iikubo M, Hino S, Hibi H, Katsura K, Nakamura S, Nomura T, Mori Y, Tojyo I, Kanamura N, Yamamori I, Aota K, Fujita S, Tanzawa H, Kurita H; Japanese Stomatological Society. The effects of perioperative oral management on perioperative serum albumin levels in patients treated surgically under general anesthesia: A multicenter retrospective analysis in Japan. Medicine, 2021; 100(10):e25119.
    10. Nakamichi E, Sakakura H, Mii S, Yamamoto N, Hibi H, Asai M, Takahashi M. Detection of serum/salivary exosomal Alix in patients with oral squamous cell carcinoma. Oral Dis, 2021; 27(3): 439-447.
  • 2020年
    1. Ogisu K, Fujio M , Tsuchiya S, Tsuboi M , Qi Chang , Toyama N, Kamio H , Hibi H.Conditioned media from mesenchymal stromal cells and periodontal ligament fibroblasts under cyclic stretch stimulation promote bone healing in mouse calvarial defects. Cytotherapy, 2020;22: 543-551.
    2. Kamio H, Tsuchiya S, Kuroda K, Okido M, Okabe K, Ohta Y, Toyama N, Hibi H. Chondroitin-4-sulfate transferase-1 depletion inhibits formation of a proteoglycan-rich layer and alters immunotolerance of bone marrow mesenchymal stem cells on titanium oxide surfaces. Acta Biomater, 2020; 114: 460-470.
    3. Toyama N, Tsuchiya S, Kamio H, Okabe K, Kuroda K, Okido M, Hibi H. The effect of macrophages on an atmospheric pressure plasma-treated titanium membrane with bone marrow stem cells in a model of guided bone regeneration. J Mater Sci Mater Med, 2020; 31: 70.
    4. Ohara Y, Enomoto A, Tsuyuki Y, Sato K, Iida T, Kobayashi H, Mizutani Y, Miyai Y, Hara A, Mii S, Suzuki J, Yamashita K, Ito F, Motooka Y, Misawa N, Fukui T, Kawaguchi K, Yokoi K, Toyokuni S. Connective tissue growth factor produced by cancer-associated fibroblasts correlates with poor prognosis in malignant mesothelioma. Oncol Rep, 2020; 44: 838–848.
    5. Koma Y, Fujimoto T, Uejima S, Sato K, Sugimoto K, Yamaguchi S, Ishikawa J, Nambu K, Hibi H. Bite injury related to oromandibular dystonia extending to the maxillary sinus: A case report. J Oral Maxillofac Surg Med Pathol, 2020; 32(6): 503-506.
    6. Sato K, Hayashi Y, Watanabe K, Hibi H. A case of Warthin tumors that were suspected to be lymph node metastases of maxillary gingival cancer. J Oral Maxillofac Surg Med Pathol, 2020; 32(4): 291-295.
    7. Kobayashi T, Iwama S, Yasuda Y, Okada N, Okuji T, Ito M, Onoue T, Goto M, Sugiyama M, Tsunekawa T, Takagi H, Hagiwara D, Ito Y, Suga H, Banno R, Yokota K, Hase T, Morise M, Hashimoto N, Ando M, Fujimoto Y, Hibi H, Sone M, Ando Y, Akiyama M, Hasegawa Y, Arima H. Pituitary dysfunction induced by immune checkpoint inhibitors is associated with better overall survival in both malignant melanoma and non-small cell lung carcinoma: a prospective study. J Immunother Cancer, 2020; 8(2): e000779.
    8. Ogasawara N, Kano F, Hashimoto N, Mori H, Yao L, Linze X, Sakamaki T, Hibi H, Iwamoto T, Tanaka E, Yamamoto A. Factors secreted from dental pulp stem cells show multifaceted benefits for treating experimental temporomandibular joint osteoarthritis. Osteo Cart, 2020; 28: 831-841.
    9. Urata Y, Saiki W, Tsukamoto Y, Sago H, Hibi H, Okajima T, Takeuchi H. Xylosyl extension of O-Glucose glycans on the extracellular domain of NOTCH1 and NOTCH2 regulates Notch cell surface trafficking. Cells, 2020; 9: E1220.
    10. Okada N, Iwama S, Okuji T, Kobayashi T, Yasuda Y, Wada E, Onoue T, Goto M, Sugiyama M, Tsunekawa T, Takagi H, Hagiwara D, Ito Y, Suga H, Banno R, Hase T, Morise M, Kanda M, Yokota K, Hashimoto N, Ando M, Fujimoto Y, Nagino M, Kodera Y, Fujishiro M, Hibi H, Sone M, Kiyoi H, Gotoh M, Ando Y, Akiyama M, Hasegawa Y, Arima H. Anti-thyroid antibodies and thyroid echo pattern at baseline as risk factors for thyroid dysfunction induced by anti-programmed cell death-1 antibodies: a prospective study, Br J Cancer, 2020; 122: 771-777.
    11. Mizuno K, Ito T, Ishigami M, Ishizu Y, Kuzuya T, Honda T, Kawashima H, Inukai Y, Toyoda H, Yokota K, Hase T, Maeda O, Kiyoi H, Nagino M, Hibi H, Kodera Y, Fujimoto Y, Sone M, Gotoh M, Ando Y, Akiyama M, Hasegawa Y, Fujishiro M. Real world data of liver injury induced by immune checkpoint inhibitors in Japanese patients with advanced malignancies. J Gastroenterol, 2020; 55: 653-661.
    12. Morita Y, Leslie M, Kameyama H, Lokesh GLR, Ichimura N, Davis R, Hills N, Hasan N, Zhang R, Kondo Y, Gorenstein DG, Volk DE, Chervoneva I, Rui H, Tanaka T. Functional Blockade of E-Selectin in Tumor-Associated Vessels Enhances Anti-Tumor Effect of Doxorubicin in Breast Cancer. Cancers, 2020; 12: e725.
    13. Okabe K, Kaneko R, Kawai T, Kano F, Ohta Y, Hibi H. Oral self-injury associated with septicaemia in a case of Cornelia de Lange syndrome. J Oral Maxillofac Surg Med Pathol, 2020; 32: 128-131.
    14. Omer A, Al-Sharabi N, Qiu Y, Li Y, Fujio M, Mustafa K, Xing Z. Biological responses of dental pulp cells to surfaces modified by collagen 1 and fibronectin. J Biomed Mater Res A, 2020; 108: 1369-1369.
    15. Watanabe J, Sakai K, Urata Y, Toyama N, Nakamichi E, Hibi H. Extracellular vesicles of stem cells to prevent BRONJ. J Dent Res, 2020; 99: 552-56.
    16. Hibi H. Iatrogenic risk of osteonecrosis of the jaw? Bone substitutes for dental implants: a warning from Japan. Nagoya J Med Sci, 2020; 1: 1-3.
    17. Hibi H. What does \"free-end missing\" mean? J Oral Implantology, 2020; 46: 172.
  • 2019年
    1. Sato K,Hayashi Y, Watanabe K, Yoshimi R, Hibi H. Concurrent chemoradiotherapy with intravenous cisplatin and docetaxel for advanced oral cancer. Nagoya J Med Sci, 2019; 81: 407-414.
    2. Sato K, Shi L, Ito F, Ohara Y, Motooka Y, Tanaka H, Mizuno M, Hori M, Hirayama T, Hibi H, Toyokuni S. Non-thermal plasma specifically kills oral squamous cell carcinoma cells in a catalytic Fe(II)-dependent manner. J Clin Biochem Nutr, 2019; 65: 8-15.
    3. Stromal cell-derived factor-1 accelerates bone regeneration through multiple regenerative mechanisms , Ando Y, Ishikawa J, Fujio M, Matsushita Y, Wakayama H, Hibi H, Yamamoto A , J Oral Maxillofac Surg Med Pathol , 2019; 31: 245-250.
    4. Intractable emphysema around the mandibular condyle: A case report , Tsurusako S, Sakakura H, Hibi H , J Oral Maxillofac Surg Med Pathol , 2019; 31: 251-253.
    5. Shimizu S, Tsuchiya S, Hirakawa A, Kato K, Ando M, Mizuno M, Osugi M, Okabe K, Katagiri W, Hibi H.Design of a Randomized Controlled Clinical Study of tissue-engineered osteogenic materials using bone marrow-derived mesenchymal cells for Maxillomandibular bone defects in Japan: the TEOM study protocol. BMC Oral Health, 2019; 19: 69.
    6. Sayo A, Konishi H, Kobayashi M, Kano K, Kobayashi H, Hibi H, Aoki J, Kiyama H. GPR34 in spinal microglia exacerbates neuropathic pain in mice. J Neuroinflammation, 2019; 16: 82.
    7. Hara K, Tsuchiya S, Hagiwara S, Fujio M, Sayo A, Hibi H. A dentigerous cyst associated with a supernumerary tooth (fourth molar) in the mandibular ramus: A case report. J Oral Maxillofac Surg Med Pathol, 2019; 31: 98-102.
  • 2018年
    1. Okabe K, Kaneko R, Usami K, Kawai T, Kano F, Hibi H. Evaluation of the effect of polaprezinc against oral mucositis associated with concurrent chemoradiotherapy. Oral Scinece in Japan, 2018: 9-10.
    2. Tsuruta T, Sakai K, Watanabe J, Katagiri W, Hibi H. Dental pulp-derived stem cell conditioned medium to regenerate peripheral nerves in a novel animal model of dysphagia. PLoS One, 2018; 13: e0208938.
    3. Fujio M, Osawa Y, Ogisu K, Tsuchiya S, Kioth H, Hibi H. A mouse distraction osteogenesis model. J Vis Exp, 2018; 141: e57925.
    4. Kano F, Ichimura N, Wakayama Y, Okabe K, Sakakura H, Hibi H. Third molar pericoronitis in neutropenia. IDCases, 2018; 13: e00419.
    5. Okabe K, Kaneko R, Kawai T, Mochiduki D, Tsuchiya S, Hibi H.Ophthalmoplegia considered to be Tolosa-Hunt syndrome: A case report. J Oral Maxillofac Surg Med Pathol, 2018; 30: 461-465.
    6. Sato K, Hayashi Y, Yamamoto N, Ichimura N, Hibi H. A case of post-transplant lymphoproliferative disorders that developed ten years after living renal transplantation in the parotid gland region.J Oral Maxillofac Surg Med Pathol, 2018; 30: 457-460.
    7. Tsuchiya S, Sugimoto K, Kamio H, Okabe K, Kuroda K, Okido M, Hibi H. Kaempferol-immobilized titanium dioxide promotes formation of new bone: effects of loading methods on bone marrow stromal cell differentiation in vivo and in vitro. Int J Nanomedicine, 2018; 13: 1665-1676.
  • 2017年
    1. Ichimura N, Yamamoto N, Nishikawa M, Sakakura H, Kano F, Sato K, Yamaguchi S, Hibi, H. Human papillomavirus-related carcinogenesis in oral cancer. Oral Science in Japan, 2017: 83-84.
    2. Ichimura N, Yamamoto N, Nishikawa M, Furue H, Kondo Y, Hibi H. Notch3 is frequently downregulated in oral cancer. J Oral Maxillofac Surg Med Pathol, 2017; 29: 504-510.
    3. Katagiri W, Watanabe J, Toyama N, Osugi M, Sakaguchi K, Hibi H. Clinical study of bone regeneration by conditioned medium from mesenchymal stem cells after maxillary sinus floor elevation. Implant Dent, 2017; 26: 607-612.
    4. Fujio M, Xing Z, Sharabi N, Xue Y, Yamamoto A, Hibi H, Ueda M, Fristad I, Mustafa K. Conditioned media from hypoxic-cultured human dental pulp cells promotes bone healing during distraction osteogenesis. J Tissue Eng Regen Med, 2017; 11: 2116-2126.
    5. Ogata K, Katagiri W, Hibi H. Secretomes from mesenchymal stem cells participate in the regulation of osteoclastogenesis in vitro. Clin Oral Investig, 2017; 21: 1979-1988.
    6. Sugimoto K, Tsuchiya S, Hara K, Matsushita Y, Hibi H. Osteoradionecrosis of the jaw caused by periapical periodontitis: A case report. J Oral Maxillofac Surg Med Pathol, 2017; 29: 328-333.
    7. Katagiri W, Sakaguchi K, Kawai T, Wakayama Y, Osugi M, Hibi H. A defined mix of cytokines mimics conditioned medium from cultures of bone marrow-derived mesenchymal stem cells and elicits bone regeneration. Cell Prolif, 2017; 50: e12333.
    8. Ito T, Ishigami M, Matsushita Y, Hirata M, Matsubara K, Ishikawa T, Hibi H, Ueda M, Hirooka Y, Goto H, Yamamoto A. Secreted ectodomain of SIGLEC-9 and MCP-1 synergistically improve acute liver failure in rats by altering macrophage polarity. Sci Rep, 2017; 7: 44043.
    9. Kano F, Matsubara K, Ueda M, Hibi H, Yamamoto A. Secreted ectodomain of sialic acid-binding Ig-like lectin-9 and MCP-1 synergistically regenerate transected rat peripheral nerves by altering macrophage polarity. Stem Cells, 2017; 35: 641-653.
    10. Sakaguchi K, Katagiri W, Osugi M, Kawai T, Sugimura-Wakayama Y, Hibi H. Periodontal tissue regeneration using the cytokine cocktail mimicking secretomes in the conditioned media from human mesenchymal stem cells. Biochem Biophys Res Commun, 2017; 484: 100-106.
  • 2016年
    1. Hirata M, Ishigami M, Matsushita Y, Ito T, Hattori H, Hibi H, Goto H, Ueda M, Yamamoto A. Multifaceted therapeutic benefits of factors derived from dental pulp stem cells for mouse liver fibrosis. Stem cells Transl Med, 2016; 5: 1416-1424.
    2. Shimojima C, Takeuchi H, Jin S, Parajuli B, Hattori H, Suzumura A, Hibi H, Ueda M, Yamamoto A. Conditioned medium from the stem cells of human exfoliated deciduous teeth ameliorates experimental autoimmune encephalomyelitis. J Immunol, 2016; 15: 4164-4171.
    3. Katagiri W, Osugi M, Kawai T, Hibi H. First-in-human study and clinical case reports of the alveolar bone regeneration with the secretome from human mesenchymal stem cells. Head Face Med, 2016; 12: 5.
    4. Hibi H. Clinical review of bone regenerative medicine and maxillomandibular reconstruction. Oral Sci Int, 2016; 13: 15-19.
    5. Sakakura H, Mii S, Hagiwara S, Kato T, Yamamoto N, Hibi H, Takahashi M, Murakumo Y. CD109 is a component of exosome secreted from cultured cells. Biochem Biophys Res Commun, 2016; 469: 816-822.
    6. Ishikawa J, Takahashi N, Matsumoto T, Yoshioka Y, Yamamoto N, Nishikawa M, Hibi H, Ishiguro N, Ueda M, Furukawa K, Yamamoto A. Factors secreted from dental pulp stem cells show multifaceted benefits for treating experimental rheumatoid arthritis. Bone, 2016; 83: 210-219.
    7. Sugimoto K, Tsuchiya S, Omori M, Matsuda R, Fujio M, Kuroda K, Okido M, Hibi H. Proteomic analysis of bone proteins adsorbed onto the surface of Etanium dioxide. Biochem Biophys Rep, 2016; 7: 316-322.
    8. Hishida S, Ozaki N, Honda T, Shigetomi T, Ueda M, Hibi H, Sugiura Y. Atrophy of submandibular gland by the duct ligaEon and a blockade of SP receptor in rats. Nagoya J Med Sci, 2016; 78: 215-227.
    9. Tsuchiya S, Sugimoto K, Omori M, Matsuda R, Fujio M, Hibi H. Mandibular osteomyeliEs implicated in infliximab and periapical periodonEEs: A case report. J Oral Maxillofac Surg Med Pathol, 2016; 28: 410-415.
    10. Yokota T,Tachibana H,Konishi T,Yurikusa T,Hmauchi S,Sakai K,Nishikawa M,Suzuki M,Naganama Y,Hagihara T,Tsumaki H,Kubo T,Sato M,Tagura M,Morita S,Eguchi T,KubotaK,Zenda S.Multicenter phase II study of an oral care program for patients with head and neck cancer receiving chemoradiotherapy.Support Care Cancer,2016; 24: 3029-3036.
  • 2015年
    1. Yamaguchi S, Shibata R, Yamamoto N, Nishikawa M, Hibi H, Tanigawa T, Ueda M, Murohara T, Yamamoto T. Dental pulp-derived stem cell conditioned medium reduces cardiac injury following ischemia-reperfusion. Sci Rep, 2015; 5: 16295.
    2. Izumoto-Akita T, Tsunekawa S, Yamamoto A, Uenishi E, Ishikawa K, Ogata H, Iida A, Ikeniwa M, Hosokawa K, Niwa Y, Maekawa R, Yamauchi Y, Seino Y, Hamada Y, Hibi H, Arima H, Ueda M, Oiso Y. Secreted factors from dental pulp stem cells improve glucose intolerance in streptozotocin-induced diabetic mice by increasing pancreatic beta-cell function. BMJ Open Diab Res Care, 2015; 3: e000128.
    3. Katagiri W, Osugi M, Kinoshita K, Hibi H. Conditioned medium from mesenchymal stem cells enhances early bone regeneration after maxillary sinus floor elevation in rabbits. Implant Dent, 2015; 24: 657-663.
    4. Katagiri W, Osugi M, Kawai T, Hibi H. Secreted frizzled-related protein promotes bone regeneration by human bone marrow-derived mesenchymal stem cells. Int J Mol Sci, 2015; 16: 23250-23258.
    5. Tsuchiya S, Ohmori M, Hara K, Fujio M, Ikeno M, Hibi H, Ueda M. An experimental study on guided bone regeneration using a polylactide-co-glycolide membrane-immobilized conditioned medium. Int J Oral Maxillofac Implants, 2015; 30: 1175-1186.
    6. Mita T, Furukawa-Hibi Y, Takeuchi H, Hattori H, Yamada K, Hibi H, Ueda M, Yamamoto A. Conditioned medium from the stem cells of human dental pulp improves cognitive function in a mouse model of Alzheimer's disease. Behav Brain Res, 2015; 293: 189-197.
    7. Sugimura Y, Katagiri W, Osugi M, Kawai K, Ogata K, Sakaguchi K, Hibi H. Peripheral nerve regeneration by secretomes of stem cells from human exfoliated deciduous teeth. Stem Cells Dev, 2015; 24: 2687-2699.
    8. Omori M, Tsuchiya S, Hara K, Kuroda K, Hibi H, Okido M, Ueda M. A new application of cell-free bone regeneration: immobilizing stem cells from human exfoliated deciduous teeth conditioned medium onto titanium implants using atmospheric pressure plasma treatment. Stem Cell Res Ther, 2015; 6: 124.
    9. Kawai T, Katagiri W, Osugi M, Sugimura Y, Hibi H, Ueda M. Secretomes from bone marrow derived mesenchymal stromal cells enhance periodontal tissue regeneration. Cytotherapy, 2015; 17: 369-381.
    10. Ogata K, Katagiri W, Osugi M, Kawai T, Sugimura Y, Hibi H, Nakamura S, Ueda M. Evaluation of the therapeutic effects of conditioned media from mesenchymal stem cells in a rat bisphosphonate-related osteonecrosis of the jaw-like model. Bone, 2015; 74: 95-105.
    11. Matsubara K, Matsushita Y, Sakai K, Kano F, Kondo M, Noda M, Hashimoto N, Imagama S, Ishiguro N, Suzumura A, Ueda M, Furukawa K, Yamamoto A. Secreted ectodomain of sialic acid-binding Ig-like lectin-9 and monocyte chemoattractant protein-1 promote recovery aftertax spinal cord injury by altering macrophage polarity. J Neurosci, 2015; 35: 2452-2464.
    12. Fujii H, Matsubara K, Sakai K, Ito M, Ohio K, Ueda M, Yamamoto A. Dopaminergic differentiation of stem cells from human deciduous teeth and their therapeutic benefits for Parkinsonian rats. Brain Res, 2015; 161: 59-72.
    13. Wakayama H, Hashimoto N, Matsushita Y, Matsubara K, Yamamoto N, Hasegawa Y, Ueda M, Yamamoto A. Factors secreted from dental pulp stem cells show multifaceted benefits for treating acute lung injury in mice. Cytotherapy, 2015; 17: 1119-1129.
    14. MatsushitaY, Ishigami M, Matsubara K, Kondo M, Wakayama H, Goto H, Ueda M, Yamamoto A. Multifaceted therapeutic benefits of factors derived from stem cells from human exfoliated deciduous teeth for acute liver failure in rats. J Tissue Eng Regen Med, 2015; 10.1002/term.2086.
    15. Hattori Y, Kim H, Tsuboi N, Yamamoto A, Akiyama S, Shin Y, Katsuno T, Kosugi T, Ueda M, Matsuo S, Maruyama S. Therapeutic Potential of Stem Cells from Human Exfoliated Deciduous Teeth in Models of Acute Kidney Injury. PLoS One, 2015; 10: e0140121.
    16. Fujio M, Xing Z, Sharabi N, Xue Y, Yamamoto A, Hibi H, Ueda M, Fristad I, Mustafa K. Conditioned media from hypoxic-cultured human dental pulp cells promotes bone healing during distraction osteogenesis. J Tissue Eng Regen Med, 2015; 10.1002/term.2109.
    17. Sakakura H, Mii S, Hagiwara S, Kato T, Yamamoto N, Hibi H, Takahashi M, Murakumo Y. CD109 is a component of exosome secreted from cultured cells. Biochem Biophysics Res Commun, 2015; 469: 816-822.
    18. Ichimura N, Shinjo K, An B, Shimizu Y, Yamao K, Ooka F, Katsushima K, Hatanaka A, Tojo M, Yamamoto E, Suzuki H, Ueda M, Kondo Y. Aberrant TET1 methylation closely associated with CpG island methylation phenotype in colorectal cancer. Cancer Prev Res, 2015; 8: 702-711.
    19. Zhang JM, Murakumo Y, Hagiwara S, Jiang P, Mii S, Kalyoncu E, Saito S, Suzuki C, Sakurai Y, Numata Y, Yamamoto T, Takahashi M. CD109 attenuates TGF-beta1 signaling and enhances EGF signaling in SK-MG-1 human glioblastoma cells. Biochem Biophysics Res Commun, 2015; 459: 252-258.
    20. Nagamine K, Hung GC, Li B, Lo SC. DNA sequence signatures for rapid detection of six target bacterial pathogens using PCR assays. Microbiology Insights, 2015; 8: 7-14.
    21. Lo SC, Hung GC, Li B, Lei H, Li T, Nagamine K, Asai S, Zucker MJ, Olesnicky L. Mixed group of Rhizobiales microbes in lung and blood of a patient with fatal pulmonary illness. Int J Clin Exp Pathol, 2015; 8: 13824-13852.
  • 2014年
    1. Sugiyama M, Hattori H, Inoue T, Wakita H, Hibi H, Ueda M. Stem cells from human exfoliated deciduous teeth enhance recovery from focal cerebral ischemia in rats. J Oral Maxillofac Surg Med Pathol, 2014; 26: 443-449.
    2. Ando Y, Matsubara K, Ishikawa J, Fujio M, Shohara R, Hibi H, Ueda M, Yamamoto A. Stem cell-conditioned medium accelerates distraction osteogenesis through multiple regenerative mechanisms. Bone, 2014; 61: 82-90.
    3. Sakakura H,Murakumo Y,Mii S,Hagiwara S,Kato T,Asai M,Hoshino A,Yamamoto N,Sobue S,Ichihara M,Ueda M,Takahashi M.Detection of a soluble from of CD109 transgenic and tumor xenografted mice.PLoS One, 2014; 9: e83385.
    4. Ueda M. A novel approach for skin rejuvenation by regenerative medicine: delivery of stem cell-derived growth factors through an iontophoretic system. Int J Oral Maxillofac Implants, 2014; 29: e59-65.
    5. Yamamoto A, Matsubara K, Kano F, Sakai K. Analysis of the neuroregeneratie activities of mesenchymal stem cells in functional recovery after rat spinal cord injury. Methods in Molecular Biology, 2014; 1213: 321-328.
    6. Yamamoto A, Sakai K, Matsubara K, Kano F, Ueda M. Multifaceted neuro-regenrative activities of human dental pulp stem cells for functional recovery after spinal cord injury. Nerosci, 2014; 78: 16-20.
    7. Hironaka K, Ozaki N, Hattori H, Nagamine K, Nakashima H, Ueda M, Sugiura Y. Involvement of glial activation in trigeminal ganglion in a rat model of lower gingival cancer pain. Nagoya J Med Sci, 2014; 76: 323-332.
    8. Yamano S, Haku K, Yamanaka T, Dai J, Takayama T, Shohara R, Tachi K, Ishioka M, Hanatani S, Karunagaran S, Wada K, Morse AM. The effect of a bioactive collagen membrane releasing PDGF or GDF-5 on bone regeneration. Biomaterials, 2014; 35: 2446-2453.
    9. Uejima S, Fujimoto T, Yokooji M, Mitsudo K, Tohnai I, Ueda M. Synchronous bilateral young cancer treated with chemoradiotherapy using super selective intra-arterial infusion via bilateral superficial temporal arteries: a case report. Head and Neck Oncol, 2014; 18: 42.
  • 2013年
    1. Ikeno M, Hibi H, Kinoshita K, Hattori H, Ueda M. Effects of permeability of shields with autologous bone grafts on bone augmentation. Int J Oral Maxillofac Implants, 2013; 28: e386-e392.
    2. Ikeno M, Hibi H, Kinoshita K, Hattori H, Ueda M. Effects of self-assembling peptide hydrogel scaffold on bone regeneration with recombinant human bone morphogenetic protein-2. Int J Oral Maxillofac Implants, 2013; 28: e283-e289.
    3. Tateishi H, Okamoto Y, Kinoshita K, Hibi H, Ueda M. Effects of implant surface on bone healing around titanium screw implants in ovariectomized rats. Int J Oral Maxillofac Implants, 2013; 28: e252-e259.
    4. Tsuchiya S, Hara K, Ikeno M, Okamoto Y, Hibi H, Ueda M. Rat bone marrow stromal cell-conditioned medium promotes early osseointegration of titanium implants. Int J Oral Maxillofac Implants, 2013; 28: 1360-1369.
    5. Hagiwara S, Yamamoto N, Furue H, Sakakura H, Shigetomi T, Murakumo Y, Hibi H, Takahashi M, Ueda M. Pathological analysis of Ki-67 and CD109 expression in tongue squamous cell carcinoma. J Oral Maxillofac Surg Med Pathol, 2013; 25: 276-287.
    6. Inukai T, Katagiri W, Yoshimi R, Osugi M, Kawai T, Hibi H, Ueda M. Novel application of stem cell-derived factors for periodontal regeneration. Biochem Biophys Res Commun, 2013; 430: 763-768.
    7. Yamada Y, Nakamura S, Ueda M, Ito K. Osteotome technique with injectable tissue-engineered bone and simultaneous implant placement by cell therapy. Clin Oral Implants Res, 2013; 24: 468-474.
    8. Katagiri W, Osugi M, Kawai T, Ueda M. Novel cell- free regeneration of bone using stem cell-derived growth factors. Int J Oral Maxillofac Implants, 2013; 28: 1009-1016.
    9. Tamari M, Nishino Y, Yamamoto N, Ueda M. Acceleration of wound healing with stem cell-derived growth factors. Int J Oral Maxillofac Implants, 2013; 28: e369-375.
    10. Nishiguchi H, Mitsudo K, Yamamoto N, Tohnai, I. Thermochemoradiotherapy using super selective intra-arterial infusion for N3 cervical lymph node metastases of tongue cancer. J Cancer Res Ther, 2013; 9: 718-720.
    11. Yamada Y, Nakamura S, Ueda M, Ito K. Papilla regeneration by injectable stem cell therapy with regenerative medicine: long-term clinical prognosis. J Tissue Eng Regen Med, 2013; 10.1002/term.1737.
    12. Yamagata M, Yamamoto A, Kako E, Kaneko N, Matsubara K, Sakai K, Sawamoto K, Ueda M. Human dental pulp-derived stem cells protect against hypoxic-ischemic brain injury in neonatal mice. Stroke, 2013; 44: 551-554.
    13. Hagiwara S, Yamamoto N, Furue H, Sakakura H, Shigetomi T, Murakumo Y, Hibi H, Takahashi H, Ueda M. Pathological analysis of Ki-67 and CD109 expression in tongue squamous cell carcinoma. J Oral Maxillofac Sure Med Pathol, 2013; 25: 276-281.

研究キーワード

組織工学、再生医療、骨再生、培養上清、細胞外小胞、扁平上皮癌

大学院医学系研究科博士課程

頭頸部・感覚器外科学講座 顎顔面外科学では学際的に医学博士課程プログラムを展開しており、科学的発見にとどまらず臨床に結びつけることを重要視し、この分野の次世代のリーダーを育成します。