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脳神経病態制御学精神医学

概要

患者さんやご家族のニーズを考慮し、「日々の臨床的な疑問の解決」を進めるとともに、「病因や病態の解明を行い、その知見に基づいた診断法や治療法・予防法の開発」を目指すことが当講座の基本的な方針です。この目標を達成するためには、臨床研究と基礎研究が互いに連携しながら進められることが非常に重要です。
当講座では、統合失調症、うつ病、双極症、認知症、自閉スペクトラム症など、多岐にわたる精神障害に関する診断・治療法や病因・病態について、bio-psycho-social（生物・心理・社会的）な観点から包括的に研究を行っています。

研究プロジェクト

ゲノム　

  • ゲノム研究チームでは、さまざまなゲノム解析手法を用いた精神疾患の病態生理研究や薬理ゲノム学的研究を行っております。具体的には、全ゲノム関連解析や全ゲノムシークエンス解析を行い、精神疾患の新規診断法や治療反応予測法の開発、さらにはそれらの結果を元とした臨床研究や、基礎研究者と連携した病因・病態解明研究を実施しております。

  • 精神疾患を対象に、T2T（Telomere-to-Telomere）ロングリードシークエンス技術を用いてゲノム全域のバリアント検出を実施しています。従来解読困難だった領域も含め、疾患リスクに関わる遺伝的バリアントを包括的に解析しています。

精神療法　

  • 精神力動的精神医学とリエゾン精神医学を実践しています。がん患者や臓器移植患者の精神医学的疾患合併症について、抑うつ・不安に関連する心理社会的因子を検討し、早期発見と介入を目指しています。また、歯科領域の慢性疼痛患者を対象に、心理社会的評価を通じてストレス関連疾患の病態解明、治療法の開発に取り組みます。

臨床薬理・疫学　

  • 各種向精神薬の有効性、安全性、適正使用に関する臨床研究・疫学研究を行っています。臨床試験のみならず、リアルワールドデータを活用した研究など、臨床的な視点を重視した、新たなエビデンスの創出を目指しています。

  • 脳波、筋電図、睡眠、精神状態などの生体情報を基に疾患マーカーを探索し、進歩したウェアラブルデバイスの検証を通じて、臨床や在宅検査の可能性を探求しています。

神経病理/老年精神医学　

  • 名古屋ブレインバンクコンソーシアムを構築し、「精神症状の病理学的背景の解明」を目標として、統合失調症から神経変性疾患まで幅広いヒト脳組織解析を実施しています。世界的にも希少な精神科ブレインバンクは、病態解明に不可欠です。臨床研究では、認知症前駆期の精神症状に着目し、老年期発症精神疾患における神経画像などの診断バイオマーカーの検索やレビー小体型認知症の早期診断に注力しています

児　童　

  • 児童グループでは、神経発達症の遺伝学的研究、臨床研究を行うとともに、精神科および小児科を基盤とするサブスペシャルティである児童精神科（子どものこころの臨床領域）研修に関する研究を行っています。また、モンゴル国における児童精神科医養成プログラムの開発、運営にも協力しています。

画　像　

  • 主にMRIを用いて、精神疾患の病態解明や、診断補助・治療の効果判定・予後の予測などを目標とし研究を行っています。また、脳の構造や機能と認知機能、眼球運動などの臨床データとの関連も検討しています。

精神病理

  • 精神疾患全般や社会的ひきこもりを含む疾患周縁の精神病理と精神療法に関する研究を行い、記述的症例報告を通じてclinical case conferenceを実施しています。また、精神疾患の治療におけるガイドラインの普及に関する研究も行っています。

妊産婦　

  • 妊産婦は特にうつ病になりやすく、その影響は心身の健康や育児に及びます。遺伝要因と環境要因を検討するため、エピゲノム解析やAI解析を用いた前向きゲノムコホート研究を行い、妊産婦のうつ病との関係を明らかにすることを目指しています。

基　礎　

  • 発症リスクバリアントに基づく精神疾患モデル細胞・動物を活用し、精神疾患の創薬研究を行っています。また、精神疾患患者由来のiPS細胞を用いて、病態の解明と治療法の開発を目指しています。

教員

構成員名役職所属
池田 匡志 教授 大学院医学系研究科 総合医学専攻
尾崎 紀夫 特任教授 大学院医学系研究科 精神疾患病態解明学 糖鎖生命コア研究所 細胞・個体制御部門
藤城 弘樹 特任教授 大学院医学系研究科 精神医療学寄附講座
木村 宏之 准教授 大学院医学系研究科 総合医学専攻
岩本 邦弘 准教授 大学院医学系研究科 総合医学専攻
Branko Aleksic 特任准教授 大学院医学系研究科 名古屋大学・アデレード大学国際連携総合医学専攻
久島 周 病院講師 医学部附属病院 ゲノム医療センター
木村 大樹 講師 大学院医学系研究科 総合医学専攻
鳥井 洋太 講師 医学部附属病院 精神科
山本 真江里 講師 医学部附属病院 精神科
加藤 秀一 特任講師 大学院医学系研究科 精神医療学寄附講座
小笠原 一能 病院助教 医学部附属病院 卒後臨床研修・キャリア形成支援センター
立花 昌子 助教 医学部附属病院 精神科
名和 佳弘 助教 医学部附属病院 親と子どもの心療科
岩田 邦幸 助教 医学部附属病院 精神科
荒深 周生 病院助教 医学部附属病院 化学療法部
竹田 和弘 病院助教 医学部附属病院 精神科
林 優 特任助教 大学院医学系研究科 障害児（者）医療学寄附講座
森 大輔 特任准教授 脳とこころの研究センター 研究開発部門
有岡 祐子 特任講師 医学部附属病院 先端医療・臨床研究支援センター
宮田 聖子 特任講師 大学院医学系研究科 精神医療学寄附講座
奥村 啓樹 特任助教 大学院医学系研究科

研究実績

  • 2024年
    1. Arafuka S, Fujishiro H, Torii Y, Sekiguchi H, Habuchi C, Miwa A, Yoshida M, Iritani S, Iwasaki Y, Ikeda M and Ozaki N. Neuropathological substrate of incident dementia in older patients with schizophrenia: A clinicopathological study. Psychiatry Clin Neurosci 2024; 78: 29-40. 20230929. DOI: 10.1111/pcn.13597.
    2. Arafuka S, Torii Y, Fujishiro H, Sekiguchi H, Miwa A, Habuchi C, Sasada K, Yoshida M, Iritani S, Iwasaki Y and Ikeda M. Premorbid autistic traits in phenocopy syndrome of behavioral variant frontotemporal dementia: An autopsy revealing primary age-related tauopathy. Asian J Psychiatr 2025; 103: 104314. 20241118. DOI: 10.1016/j.ajp.2024.104314.
    3. Ashizawa T, Saito T, Okochi T, Ninomiya K, Ito K, Aoki R, Ikeda M and Iwata N. Association of plasma arachidonic acid levels with a bipolar disorder and the effects of a fads gene variant. Transl Psychiatry 2024; 14: 435. 20241014. DOI: 10.1038/s41398-024-03141-1.
    4. Ebina T, Iwamoto K and Ikeda M. Brexpiprazole-related tardive dystonia in a young patient with schizophrenia: A case report. Psychiatry Clin Neurosci 2024; 78: 334-335. 20240226. DOI: 10.1111/pcn.13653.
    5. Furukawa S, Arafuka S, Kato H, Ogi T, Ozaki N, Ikeda M and Kushima I. Treatment-resistant schizophrenia with 22q11.2 deletion and additional genetic defects. Neuropsychopharmacol Rep 2024; 44: 847-851. 20240827. DOI: 10.1002/npr2.12477.
    6. Furukawa S, Kushima I, Kato H, Kimura H, Nawa Y, Aleksic B, Banno M, Yamamoto M, Uematsu M, Nagasaki Y, Ogi T, Ozaki N and Ikeda M. Whole-genome sequencing analysis of japanese autism spectrum disorder trios. Psychiatry Clin Neurosci 2025; 79: 87-97. 20241128. DOI: 10.1111/pcn.13767.
    7. Hatanaka M, Hara K, Ohba C, Suzuki M, Ogura A, Kawabata K, Ito Y, Tada T, Fujita N, Mori D, Maesawa S, Kato K and Katsuno M. Combined quantitative analysis of the nigro-striata system in multiple system atrophy and parkinson's disease. J Neurol Sci 2025; 468: 123331. 20241126. DOI: 10.1016/j.jns.2024.123331.
    8. Hayashi Y, Okumura H, Arioka Y, Kushima I, Mori D, Lo T, Otgonbayar G, Kato H, Nawa Y, Kimura H, Aleksic B and Ozaki N. Analysis of human neuronal cells carrying astn2 deletion associated with psychiatric disorders. Transl Psychiatry 2024; 14: 236. 20240603. DOI: 10.1038/s41398-024-02962-4.
    9. Hori A, Su X, Sagasaki S, Saito R, Suijo K, Miyata S, Hasegawa D, Mizuno M and Hotta N. Sleep deprivation elevates resting and exercise blood pressures and augments pressor response at exercise onset. Med Sci Sports Exerc 2024 20241230. DOI: 10.1249/mss.0000000000003640.
    10. Inada T, Tanabe Y, Fukaya Y, Ogasawara K and Yamamoto N. Severity of antipsychotic-induced cervical dystonia assessed by the algorithm-based rating system. J Clin Psychiatry 2024; 85 20240415. DOI: 10.4088/JCP.23m14929.
    11. Ishikawa M, Yamamoto Y, Wulaer B, Kunisawa K, Fujigaki H, Ando T, Kimura H, Kushima I, Arioka Y, Torii Y, Mouri A, Ozaki N, Nabeshima T and Saito K. Indoleamine 2,3-dioxygenase 2 deficiency associates with autism-like behavior via dopaminergic neuronal dysfunction. Febs j 2024; 291: 945-964. 20240102. DOI: 10.1111/febs.17019.
    12. Iwamoto K, Nakabayashi T, Yamaguchi A, Konishi Y, Saji M, Yoshimura R, Kanemoto K, Aoki H, Ando M and Ozaki N. Effects of frequently prescribed antiseizure medications on motor vehicle driving performance: Narrative review based on a tiered approach for the assessment of clinically meaningful driving impairment in the ministry of health, labour, and welfare guideline. Neuropsychopharmacol Rep 2024; 44: 682-687. 20241104. DOI: 10.1002/npr2.12469.
    13. Kato T, Ogasawara K, Motomura K, Kato M, Tanaka T, Takaesu Y, Nio S, Kishi T, So M, Nemoto K, Suzuki E, Watanabe K and Matsuo K. Practice guidelines for bipolar disorder by the jsmd (japanese society of mood disorders). Psychiatry Clin Neurosci 2024; 78: 633-645. 20240828. DOI: 10.1111/pcn.13724.
    14. Kobayashi R, Iwata-Endo K and Fujishiro H. Clinical presentations and diagnostic application of proposed biomarkers in psychiatric-onset prodromal dementia with lewy bodies. Psychogeriatrics 2024; 24: 1004-1022. 20240604. DOI: 10.1111/psyg.13147.
    15. Koromina M, Ravi A, Panagiotaropoulou G, Schilder BM, Humphrey J, Braun A, Bidgeli T, Chatzinakos C, Coombes B, Kim J, Liu X, Terao C, KS OC, Adams M, Rolf A, Alda M, Alfredsson L, Andlauer TFM, Andreassen OA, Antoniou A, Baune BT, Bengesser S, Biernacka J, Boehnke M, Bosch R, Cairns MJ, Carr VJ, Casas M, Catts S, Cichon S, Corvin A, Craddock N, Dafnas K, Dalkner N, Dannlowski U, Degenhardt F, Florio AD, Dikeos D, Fellendorf FT, Ferentinos P, Forstner AJ, Forty L, Frye M, Fullerton JM, Gawlik M, Gizer IR, Gordon-Smith K, Green MJ, Grigoroiu-Serbanescu M, Guzman-Parra J, Hahn T, Henskens F, Hillert J, Jablensky AV, Jones L, Jones I, Jonsson L, Kelsoe JR, Kircher T, Kirov G, Kittel-Schneider S, Kogevinas M, Landén M, Leboyer M, Lenger M, Lissowska J, Lochner C, Loughland C, MacIntyre D, Martin NG, Maratou E, Mathews CA, Mayoral F, McElroy SL, McGregor NW, McIntosh A, McQuillin A, Michie P, Mitchell PB, Moutsatsou P, Mowry B, Müller-Myhsok B, Myers RM, Nenadić I, Nievergelt C, Nöthen MM, Nurnberger J, M OD, O'Donovan C, Ophoff RA, Owen MJ, Pantelis C, Pato C, Pato MT, Patrinos GP, Pawlak JM, Perlis RH, Porichi E, Posthuma D, Ramos-Quiroga JA, Reif A, Reininghaus EZ, Ribasés M, Rietschel M, Schall U, Schofield PR, Schulze TG, Scott L, Scott RJ, Serretti A, Weickert CS, Smoller JW, Artigas MS, Stein DJ, Streit F, Toma C, Tooney P, Vawter MP, Vieta E, Vincent JB, Waldman ID, Weickert T, Witt SH, Hong KS, Ikeda M, Iwata N, Świątkowska B, Won HH, Edenberg HJ, Ripke S, Raj T, Coleman JRI and Mullins N. Fine-mapping genomic loci refines bipolar disorder risk genes. medRxiv 2024 20240917. DOI: 10.1101/2024.02.12.24302716.
    16. Koyama S, Liu X, Koike Y, Hikino K, Koido M, Li W, Akaki K, Tomizuka K, Ito S, Otomo N, Suetsugu H, Yoshino S, Akiyama M, Saito K, Ishikawa Y, Benner C, Natarajan P, Ellinor PT, Mushiroda T, Horikoshi M, Ikeda M, Iwata N, Matsuda K, Niida S, Ozaki K, Momozawa Y, Ikegawa S, Takeuchi O, Ito K and Terao C. Population-specific putative causal variants shape quantitative traits. Nat Genet 2024; 56: 2027-2035. 20241003. DOI: 10.1038/s41588-024-01913-5.
    17. Kushima I, Nakatochi M and Ozaki N. Copy number variations and human well-being: Integrating psychiatric, physical, and socioeconomic perspectives. Biol Psychiatry 2024 20241204. DOI: 10.1016/j.biopsych.2024.11.019.
    18. Lo T, Kushima I, Kimura H, Aleksic B, Okada T, Kato H, Inada T, Nawa Y, Torii Y, Yamamoto M, Kimura R, Funabiki Y, Kosaka H, Numata S, Kasai K, Sasaki T, Yokoyama S, Munesue T, Hashimoto R, Yasuda Y, Fujimoto M, Usami M, Itokawa M, Arai M, Ohi K, Someya T, Watanabe Y, Egawa J, Takahashi T, Suzuki M, Yamasue H, Iwata N, Ikeda M and Ozaki N. Association between copy number variations in parkin (prkn) and schizophrenia and autism spectrum disorder: A case-control study. Neuropsychopharmacol Rep 2024; 44: 42-50. 20231101. DOI: 10.1002/npr2.12370.
    19. Miura K, Yoshida M, Morita K, Fujimoto M, Yasuda Y, Yamamori H, Takahashi J, Miyata S, Okazaki K, Matsumoto J, Toyomaki A, Makinodan M, Hashimoto N, Onitsuka T, Kasai K, Ozaki N and Hashimoto R. Gaze behaviors during free viewing revealed differences in visual salience processing across four major psychiatric disorders: A mega-analysis study of 1012 individuals. Mol Psychiatry 2025; 30: 1594-1600. 20241011. DOI: 10.1038/s41380-024-02773-5.
    20. Miyake N, Tsurusaki Y, Fukai R, Kushima I, Okamoto N, Ohashi K, Nakamura K, Hashimoto R, Hiraki Y, Son S, Kato M, Sakai Y, Osaka H, Deguchi K, Matsuishi T, Takeshita S, Fattal-Valevski A, Ekhilevitch N, Tohyama J, Yap P, Keng WT, Kobayashi H, Takubo K, Okada T, Saitoh S, Yasuda Y, Murai T, Nakamura K, Ohga S, Matsumoto A, Inoue K, Saikusa T, Hershkovitz T, Kobayashi Y, Morikawa M, Ito A, Hara T, Uno Y, Seiwa C, Ishizuka K, Shirahata E, Fujita A, Koshimizu E, Miyatake S, Takata A, Mizuguchi T, Ozaki N and Matsumoto N. Molecular diagnosis of 405 individuals with autism spectrum disorder. Eur J Hum Genet 2024; 32: 1551-1558. 20230327. DOI: 10.1038/s41431-023-01335-7.
    21. Miyata S, Iwamoto K, Okada I, Fujimoto A, Kogo Y, Mori D, Amano M, Matsuyama N, Nishida K, Ando M, Taoka T, Naganawa S and Ozaki N. Assessing the real-world, long-term impact of lemborexant on sleep quality in a home-based clinical study. Nat Sci Sleep 2024; 16: 291-303. 20240319. DOI: 10.2147/nss.S448871.
    22. Mori D, Ikeda R, Sawahata M, Yamaguchi S, Kodama A, Hirao T, Arioka Y, Okumura H, Inami C, Suzuki T, Hayashi Y, Kato H, Nawa Y, Miyata S, Kimura H, Kushima I, Aleksic B, Mizoguchi H, Nagai T, Nakazawa T, Hashimoto R, Kaibuchi K, Kume K, Yamada K and Ozaki N. Phenotypes for general behavior, activity, and body temperature in 3q29 deletion model mice. Transl Psychiatry 2024; 14: 138. 20240307. DOI: 10.1038/s41398-023-02679-w.
    23. Mori D, Inami C, Ikeda R, Sawahata M, Urata S, Yamaguchi ST, Kobayashi Y, Fujita K, Arioka Y, Okumura H, Kushima I, Kodama A, Suzuki T, Hirao T, Yoshimi A, Sobue A, Ito T, Noda Y, Mizoguchi H, Nagai T, Kaibuchi K, Okabe S, Nishiguchi K, Kume K, Yamada K and Ozaki N. Mice with deficiency in pcdh15, a gene associated with bipolar disorders, exhibit significantly elevated diurnal amplitudes of locomotion and body temperature. Transl Psychiatry 2024; 14: 216. 20240528. DOI: 10.1038/s41398-024-02952-6.
    24. Morikawa F, Kobayashi R, Murayama T, Fukuya S, Tabata K, Fujishiro H, Nakayama M and Naoe J. Evaluating electroconvulsive therapy for dementia with lewy bodies, including the prodromal stage: A retrospective study on safety and efficacy. Int J Geriatr Psychiatry 2024; 39: e70020. DOI: 10.1002/gps.70020.
    25. Mukoyama N, Nishio N, Kimura H, Tokura T, Kishi S, Ogasawara K, Tsuzuki H, Yokoi S, Wada A, Shigeyama M, Ozaki N, Fujimoto Y and Sone M. Anxiety, depression and quality of life in patients with head and neck cancer undergoing laryngectomy: A long-term prospective evaluation. Int J Lang Commun Disord 2024; 59: 1865-1877. 20240422. DOI: 10.1111/1460-6984.13036.
    26. Nakabayashi T, Iwamoto K, Yamaguchi A, Konishi Y, Saji M, Yoshimura R, Kanemoto K, Aoki H, Ando M and Ozaki N. Guideline for evaluating the effects of psychotropic drugs on motor vehicle driving performance in japan: A tiered approach for the assessment of clinically meaningful driving impairment. Neuropsychopharmacol Rep 2024; 44: 308-313. 20240416. DOI: 10.1002/npr2.12436.
    27. Nakamura M, Yoshimi A, Tokura T, Kimura H, Kishi S, Miyauchi T, Iwamoto K, Ito M, Sato-Boku A, Mouri A, Nabeshima T, Ozaki N and Noda Y. Duloxetine improves chronic orofacial pain and comorbid depressive symptoms in association with reduction of serotonin transporter protein through upregulation of ubiquitinated serotonin transporter protein. Pain 2024; 165: 1177-1186. 20240111. DOI: 10.1097/j.pain.0000000000003124.
    28. Nakamura Y, Shimada IS, Maroofian R, Falabella M, Zaki MS, Fujimoto M, Sato E, Takase H, Aoki S, Miyauchi A, Koshimizu E, Miyatake S, Arioka Y, Honda M, Higashi T, Miya F, Okubo Y, Ogawa I, Scardamaglia A, Miryounesi M, Alijanpour S, Ahmadabadi F, Herkenrath P, Dafsari HS, Velmans C, Al Balwi M, Vitobello A, Denommé-Pichon AS, Jeanne M, Civit A, Abdel-Hamid MS, Naderi H, Darvish H, Bakhtiari S, Kruer MC, Carroll CJ, Ghayoor Karimiani E, Khailany RA, Abdulqadir TA, Ozaslan M, Bauer P, Zifarelli G, Seifi T, Zamani M, Al Alam C, Alvi JR, Sultan T, Efthymiou S, Pope SAS, Haginoya K, Matsunaga T, Osaka H, Matsumoto N, Ozaki N, Ohkawa Y, Oki S, Tsunoda T, Pitceathly RDS, Taketomi Y, Houlden H, Murakami M, Kato Y and Saitoh S. Biallelic null variants in pnpla8 cause microcephaly by reducing the number of basal radial glia. Brain 2024; 147: 3949-3967. DOI: 10.1093/brain/awae185.
    29. Nakatochi M, Kushima I, Aleksic B, Kimura H, Kato H, Inada T, Torii Y, Takahashi N, Yamamoto M, Iwamoto K, Nawa Y, Iritani S, Iwata N, Saito T, Ninomiya K, Okochi T, Hashimoto R, Yamamori H, Yasuda Y, Fujimoto M, Miura K, Ohi K, Shioiri T, Kitaichi K, Itokawa M, Arai M, Miyashita M, Toriumi K, Takahashi T, Suzuki M, Kato TA, Kanba S, Horikawa H, Kasai K, Ikegame T, Jinde S, Kato T, Kakiuchi C, Yamagata B, Nio S, Kunii Y, Yabe H, Okamura Y, Tadaka S, Fumihiko U, Obara T, Yamamoto Y, Arioka Y, Mori D, Ikeda M and Ozaki N. Copy number variations in rnf216 and postsynaptic membrane-associated genes are associated with bipolar disorder: A case-control study in the japanese population. Psychiatry Clin Neurosci 2025; 79: 12-20. 20241015. DOI: 10.1111/pcn.13752.
    30. Namba S, Akiyama M, Hamanoue H, Kato K, Kawashima M, Kushima I, Matsuda K, Nakatochi M, Ogishima S, Sonehara K, Suzuki K, Takata A, Tamiya G, Tanikawa C, Yamamoto K, Yamamoto N, Ozaki N and Okada Y. Inconsistent embryo selection across polygenic score methods. Nat Hum Behav 2024; 8: 2264-2267. DOI: 10.1038/s41562-024-02019-y.
    31. Okuda M, Noda A, Iwamoto K, Hishikawa N, Miyata S, Yasuma F, Taoka T, Ozaki N, Suhr JA and Miyazaki S. Assessment of cognitive function and sleep-wake rhythms in community-dwelling older adults. Sleep Biol Rhythms 2024; 22: 137-145. 20230922. DOI: 10.1007/s41105-023-00491-z.
    32. Okumura H, Hayashi Y, Arioka Y, Kushima I, Mori D and Ozaki N. Generation of induced pluripotent stem cells from a schizophrenia patient with heterozygous 1q21.1 deletion. Stem Cell Res 2024; 81: 103555. 20240912. DOI: 10.1016/j.scr.2024.103555.
    33. Otgonbayar G, Lo T, Hayashi Y, Furuta S, Aleksic B, Nawa Y, Kushima I, Kato H, Kimura H and Ozaki N. Study of the genetic association between selected 3q29 region genes and schizophrenia and autism spectrum disorder in the japanese population. Nagoya J Med Sci 2024; 86: 216-222. DOI: 10.18999/nagjms.86.2.216.
    34. Shimamoto M, Ishizuka K, Ohtani K, Inada T, Yamamoto M, Tachibana M, Kimura H, Sakai Y, Kobayashi K, Ozaki N and Ikeda M. Machine learning algorithm-based estimation model for the severity of depression assessed using montgomery-asberg depression rating scale. Neuropsychopharmacol Rep 2024; 44: 115-120. 20231220. DOI: 10.1002/npr2.12404.
    35. Suzuki K, Iwata-Endo K, Suzuki K and Fujishiro H. Late-onset delusional disorder as psychiatric-onset dementia with lewy bodies: A longitudinal follow-up study. Asian J Psychiatr 2024; 102: 104274. 20241012. DOI: 10.1016/j.ajp.2024.104274.
    36. Tachibana M, Inada T, Kimura H, Ito M, Kuwatsuka Y, Kinoshita F, Mori D and Ohno K. Extremely low frequency, extremely low magnetic environment for depression: An open-label trial. Asian J Psychiatr 2024; 96: 104036. 20240326. DOI: 10.1016/j.ajp.2024.104036.
    37. Takahashi N, Ono T, Omori Y, Iizumi M, Kato H, Kasuno S, Persing B and Tsuchiya KJ. Assessment of executive functions using a 3d-video game in children and adolescents with adhd. Front Psychiatry 2024; 15: 1407703. 20240822. DOI: 10.3389/fpsyt.2024.1407703.
    38. Teranishi M, Ito M, Huang Z, Nishiyama Y, Masuda A, Mino H, Tachibana M, Inada T and Ohno K. Extremely low-frequency electromagnetic field (elf-emf) increases mitochondrial electron transport chain activities and ameliorates depressive behaviors in mice. Int J Mol Sci 2024; 25 20241021. DOI: 10.3390/ijms252011315.
    39. Wada S, Iwamoto K, Okumura H, Hida H, Hiraoka S, Kamei A, Mori D, Yamada K, Ando M, Ozaki N and Ikeda M. Effect of single-administration of d-sorbitol pretreatment on the bitterness and continued willingness to take asenapine: A randomized, single-blind, placebo-controlled, crossover trial. BMC Psychiatry 2024; 24: 81. 20240130. DOI: 10.1186/s12888-024-05549-x.
    40. Wakuda T, Benner S, Uemura Y, Nishimura T, Kojima M, Kuroda M, Matsumoto K, Kanai C, Inada N, Harada T, Kameno Y, Munesue T, Inoue J, Umemura K, Yamauchi A, Ogawa N, Kushima I, Suyama S, Saito T, Hamada J, Kano Y, Honda N, Kikuchi S, Seto M, Tomita H, Miyoshi N, Matsumoto M, Kawaguchi Y, Kanai K, Ikeda M, Nakamura I, Isomura S, Hirano Y, Onitsuka T, Ozaki N, Kosaka H, Okada T, Kuwabara H and Yamasue H. Oxytocin-induced increases in cytokines and clinical effect on the core social features of autism: Analyses of rct datasets. Brain Behav Immun 2024; 118: 398-407. 20240308. DOI: 10.1016/j.bbi.2024.03.013.
    41. Zuunnast K, Kato H, Yokoyama K, Nawa Y, Ogawa S, Yoshikawa T, Kaneko H, Nagata M, Davaasuren O, Nomura K. Launching a child and adolescent psychiatry training program in Mongolia inspired by Japanese models. PCN Rep. 2025;4(1):e70056. doi: 10.1002/pcn5.70056.
  • 2023年
    1. Amare A, Thalamuthu A, Schubert KO, Fullerton J, Ahmed M, Hartmann S, Papiol S, Heilbronner U, Degenhardt F, Tekola-Ayele F, Hou L, Hsu YH, Shekhtman T, Adli M, Akula N, Akiyama K, Ardau R, Arias B, Aubry JM, Backlund L, Bhattacharjee AK, Bellivier F, Benabarre A, Bengesser S, Biernacka J, Birner A, Marie-Claire C, Cervantes P, Chen HC, Chillotti C, Cichon S, Cruceanu C, Czerski P, Dalkner N, Del Zompo M, DePaulo JR, Etain B, Jamain S, Falkai P, Forstner AJ, Frisén L, Frye M, Gard S, Garnham J, Goes F, Grigoroiu-Serbanescu M, Fallgatter A, Stegmaier S, Ethofer T, Biere S, Petrova K, Schuster C, Adorjan K, Budde M, Heilbronner M, Kalman J, Oraki Kohshour M, Reich-Erkelenz D, Schaupp S, Schulte E, Senner F, Vogl T, Anghelescu IG, Arolt V, Dannlowski U, Dietrich DE, Figge C, Jäger M, Lang F, Juckel G, Spitzer C, Reimer J, Schmauß M, Schmitt A, Konrad C, von Hagen M, Wiltfang J, Zimmermann J, Andlauer T, Fischer A, Bermpohl F, Kraft V, Matura S, Gryaznova A, Falkenberg I, Yildiz C, Kircher T, Schmidt J, Koch M, Gade K, Trost S, Haußleiter I, Lambert M, Rohenkohl AC, Kraft V, Grof P, Hashimoto R, Hauser J, Herms S, Hoffmann P, Jiménez E, Kahn JP, Kassem L, Kuo PH, Kato T, Kelsoe J, Kittel-Schneider S, Ferensztajn-Rochowiak E, König B, Kusumi I, Laje G, Landén M, Lavebratt C, Leboyer M, Leckband SG, Tortorella A, Manchia M, Martinsson L, McCarthy M, McElroy SL, Colom F, Mitjans M, Mondimore F, Monteleone P, Nievergelt C, Nöthen M, Novak T, O'Donovan C, Ozaki N, Pfennig A, Pisanu C, Potash J, Reif A, Reininghaus E, Rouleau G, Rybakowski JK, Schalling M, Schofield P, Schweizer BW, Severino G, Shilling PD, Shimoda K, Simhandl C, Slaney C, Squassina A, Stamm T, Stopkova P, Maj M, Turecki G, Vieta E, Veeh J, Witt S, Wright A, Zandi P, Mitchell P, Bauer M, Alda M, Rietschel M, McMahon F, Schulze TG, Millischer V, Clark S and Baune B. Association of polygenic score and the involvement of cholinergic and glutamatergic pathways with lithium treatment response in patients with bipolar disorder. Res Sq 2023 20230214. DOI: 10.21203/rs.3.rs-2580252/v1.
    2. Amare AT, Thalamuthu A, Schubert KO, Fullerton JM, Ahmed M, Hartmann S, Papiol S, Heilbronner U, Degenhardt F, Tekola-Ayele F, Hou L, Hsu YH, Shekhtman T, Adli M, Akula N, Akiyama K, Ardau R, Arias B, Aubry JM, Hasler R, Richard-Lepouriel H, Perroud N, Backlund L, Bhattacharjee AK, Bellivier F, Benabarre A, Bengesser S, Biernacka JM, Birner A, Marie-Claire C, Cervantes P, Chen HC, Chillotti C, Cichon S, Cruceanu C, Czerski PM, Dalkner N, Del Zompo M, DePaulo JR, Étain B, Jamain S, Falkai P, Forstner AJ, Frisen L, Frye MA, Gard S, Garnham JS, Goes FS, Grigoroiu-Serbanescu M, Fallgatter AJ, Stegmaier S, Ethofer T, Biere S, Petrova K, Schuster C, Adorjan K, Budde M, Heilbronner M, Kalman JL, Kohshour MO, Reich-Erkelenz D, Schaupp SK, Schulte EC, Senner F, Vogl T, Anghelescu IG, Arolt V, Dannlowski U, Dietrich D, Figge C, Jäger M, Lang FU, Juckel G, Konrad C, Reimer J, Schmauß M, Schmitt A, Spitzer C, von Hagen M, Wiltfang J, Zimmermann J, Andlauer TFM, Fischer A, Bermpohl F, Ritter P, Matura S, Gryaznova A, Falkenberg I, Yildiz C, Kircher T, Schmidt J, Koch M, Gade K, Trost S, Haussleiter IS, Lambert M, Rohenkohl AC, Kraft V, Grof P, Hashimoto R, Hauser J, Herms S, Hoffmann P, Jiménez E, Kahn JP, Kassem L, Kuo PH, Kato T, Kelsoe J, Kittel-Schneider S, Ferensztajn-Rochowiak E, König B, Kusumi I, Laje G, Landén M, Lavebratt C, Leboyer M, Leckband SG, Tortorella A, Manchia M, Martinsson L, McCarthy MJ, McElroy S, Colom F, Millischer V, Mitjans M, Mondimore FM, Monteleone P, Nievergelt CM, Nöthen MM, Novák T, O'Donovan C, Ozaki N, Pfennig A, Pisanu C, Potash JB, Reif A, Reininghaus E, Rouleau GA, Rybakowski JK, Schalling M, Schofield PR, Schweizer BW, Severino G, Shilling PD, Shimoda K, Simhandl C, Slaney CM, Squassina A, Stamm T, Stopkova P, Maj M, Turecki G, Vieta E, Veeh J, Witt SH, Wright A, Zandi PP, Mitchell PB, Bauer M, Alda M, Rietschel M, McMahon FJ, Schulze TG, Clark SR and Baune BT. Association of polygenic score and the involvement of cholinergic and glutamatergic pathways with lithium treatment response in patients with bipolar disorder. Mol Psychiatry 2023; 28: 5251-5261. 20230711. DOI: 10.1038/s41380-023-02149-1.
    3. Aoi T, Tanaka A, Furuhashi K, Ikeya M, Shimizu A, Arioka Y, Kushima I, Ozaki N and Maruyama S. ＜editors' choice＞ mesenchymal stem/stromal cells generated from induced pluripotent stem cells are highly resistant to senescence. Nagoya J Med Sci 2023; 85: 682-690. DOI: 10.18999/nagjms.85.4.682.
    4. Arafuka S, Fujishiro H, Torii Y, Sekiguchi H, Habuchi C, Miwa A, Yoshida M, Iritani S, Iwasaki Y, Ikeda M and Ozaki N. Neuropathological substrate of incident dementia in older patients with schizophrenia: A clinicopathological study. Psychiatry Clin Neurosci 2024; 78: 29-40. 20230929. DOI: 10.1111/pcn.13597.
    5. Arafuka S, Sekiguchi H, Fujishiro H, Iritani S, Torii Y, Habuchi C, Yoshida M, Iwasaki Y, Ozaki N and Fujita K. Late-onset panic disorder as the initial presentation in autopsy-confirmed dementia with lewy bodies. Psychiatry Clin Neurosci 2023; 77: 242-244. 20230206. DOI: 10.1111/pcn.13532.
    6. Arioka Y, Okumura H, Sakaguchi H and Ozaki N. Shedding light on latent pathogenesis and pathophysiology of mental disorders: The potential of ips cell technology. Psychiatry Clin Neurosci 2023; 77: 308-314. 20230404. DOI: 10.1111/pcn.13545.
    7. Fujishiro H, Arafuka S, Ogasawara K, Iwamoto K, Miyata S, Torii Y, Iritani S and Ozaki N. Temporal trajectories of proposed biomarkers in psychiatric-onset prodromal dementia with lewy bodies: A case report. Psychogeriatrics 2023; 23: 196-200. 20221201. DOI: 10.1111/psyg.12922.
    8. Furukawa S, Kushima I, Aleksic B and Ozaki N. Case reports of two siblings with autism spectrum disorder and 15q13.3 deletions. Neuropsychopharmacol Rep 2023; 43: 462-466. 20230601. DOI: 10.1002/npr2.12340.
    9. Hagikura M and Inada T. A case of schizophrenia with relapsed catatonia successfully treated with blonanserin transdermal patch. Neuropsychopharmacol Rep 2023; 43: 150-153. 20230118. DOI: 10.1002/npr2.12314.
    10. Herrera-Rivero M, Adli M, Akiyama K, Akula N, Amare AT, Ardau R, Arias B, Aubry JM, Backlund L, Bellivier F, Benabarre A, Bengesser S, Bhattacharjee AK, Biernacka JM, Birner A, Cearns M, Cervantes P, Chen HC, Chillotti C, Cichon S, Clark SR, Colom F, Cruceanu C, Czerski PM, Dalkner N, Degenhardt F, Del Zompo M, DePaulo JR, Etain B, Falkai P, Ferensztajn-Rochowiak E, Forstner AJ, Frank J, Frisén L, Frye MA, Fullerton JM, Gallo C, Gard S, Garnham JS, Goes FS, Grigoroiu-Serbanescu M, Grof P, Hashimoto R, Hasler R, Hauser J, Heilbronner U, Herms S, Hoffmann P, Hou L, Hsu YH, Jamain S, Jiménez E, Kahn JP, Kassem L, Kato T, Kelsoe J, Kittel-Schneider S, Kuo PH, Kusumi I, König B, Laje G, Landén M, Lavebratt C, Leboyer M, Leckband SG, Maj M, Manchia M, Marie-Claire C, Martinsson L, McCarthy MJ, McElroy SL, Millischer V, Mitjans M, Mondimore FM, Monteleone P, Nievergelt CM, Novák T, Nöthen MM, O'Donovan C, Ozaki N, Papiol S, Pfennig A, Pisanu C, Potash JB, Reif A, Reininghaus E, Richard-Lepouriel H, Roberts G, Rouleau GA, Rybakowski JK, Schalling M, Schofield PR, Schubert KO, Schulte EC, Schweizer BW, Severino G, Shekhtman T, Shilling PD, Shimoda K, Simhandl C, Slaney CM, Squassina A, Stamm T, Stopkova P, Streit F, Tekola-Ayele F, Thalamuthu A, Tortorella A, Turecki G, Veeh J, Vieta E, Viswanath B, Witt SH, Zandi PP, Alda M, Bauer M, McMahon FJ, Mitchell PB, Rietschel M, Schulze TG and Baune BT. Exploring the genetics of lithium response in bipolar disorders. Res Sq 2023 20231202. DOI: 10.21203/rs.3.rs-3677630/v1.
    11. Herrera-Rivero M, Gutiérrez-Fragoso K, Thalamuthu A, Amare AT, Adli M, Akiyama K, Akula N, Ardau R, Arias B, Aubry JM, Backlund L, Bellivier F, Benabarre A, Bengesser S, Abesh B, Biernacka J, Birner A, Cearns M, Cervantes P, Chen HC, Chillotti C, Cichon S, Clark S, Colom F, Cruceanu C, Czerski P, Dalkner N, Degenhardt F, Del Zompo M, DePaulo JR, Etain B, Falkai P, Ferensztajn-Rochowiak E, Forstner AJ, Frank J, Frisen L, Frye M, Fullerton J, Gallo C, Gard S, Garnham J, Goes F, Grigoroiu-Serbanescu M, Grof P, Hashimoto R, Hasler R, Hauser J, Heilbronner U, Herms S, Hoffmann P, Hou L, Hsu Y, Jamain S, Jiménez E, Kahn JP, Kassem L, Kato T, Kelsoe J, Kittel-Schneider S, Kuo PH, Kurtz J, Kusumi I, König B, Laje G, Landén M, Lavebratt C, Leboyer M, Leckband S, Maj M, Manchia M, Marie-Claire C, Martinsson L, McCarthy M, McElroy SL, Millischer V, Mitjans M, Mondimore F, Monteleone P, Nievergelt C, Novak T, Nöthen M, Odonovan C, Ozaki N, Papiol S, Pfennig A, Pisanu C, Potash J, Reif A, Reininghaus E, Richard-Lepouriel H, Roberts G, Rouleau G, Rybakowski JK, Schalling M, Schofield P, Schubert KO, Schulte E, Schweizer B, Severino G, Shekhtman T, Shilling P, Shimoda K, Simhandl C, Slaney C, Squassina A, Stamm T, Stopkova P, Streit F, Ayele F, Tortorella A, Turecki G, Veeh J, Vieta E, Viswanath B, Witt S, Zandi P, Alda M, Bauer M, McMahon F, Mitchell P, Rietschel M, Schulze T and Baune B. Immunogenetics of lithium response and psychiatric phenotypes in patients with bipolar disorder. Res Sq 2023 20230626. DOI: 10.21203/rs.3.rs-3068352/v1.
    12. Ito T, Yoshida M, Aida T, Kushima I, Hiramatsu Y, Ono M, Yoshimi A, Tanaka K, Ozaki N and Noda Y. Astrotactin 2 (astn2) regulates emotional and cognitive functions by affecting neuronal morphogenesis and monoaminergic systems. J Neurochem 2023; 165: 211-229. 20230315. DOI: 10.1111/jnc.15790.
    13. Iwamoto K, Nakabayashi T, Yamaguchi A, Konishi Y, Saji M, Yoshimura R, Kanemoto K, Aoki H, Ando M and Ozaki N. The new guideline for evaluating effects of psychotropic drugs on the performance to drive a motor vehicle in japan: Comparison with us fda guideline. Neuropsychopharmacol Rep 2023; 43: 172-176. 20230414. DOI: 10.1002/npr2.12339.
    14. Kato H, Kimura H, Kushima I, Takahashi N, Aleksic B and Ozaki N. The genetic architecture of schizophrenia: Review of large-scale genetic studies. J Hum Genet 2023; 68: 175-182. 20220712. DOI: 10.1038/s10038-022-01059-4.
    15. Kato S, Maesawa S, Bagarinao E, Nakatsubo D, Tsugawa T, Mizuno S, Kawabata K, Tsuboi T, Suzuki M, Shibata M, Takai S, Ishizaki T, Torii J, Mutoh M, Saito R, Wakabayashi T, Katsuno M, Ozaki N, Watanabe H and Sobue G. Magnetic resonance-guided focused ultrasound thalamotomy restored distinctive resting-state networks in patients with essential tremor. J Neurosurg 2023; 138: 306-317. 20220708. DOI: 10.3171/2022.5.Jns22411.
    16. Kawai K, Iwamoto K, Miyata S, Okada I, Ando M, Fujishiro H, Ando M, Noda A and Ozaki N. Lps and its relationship with subjective-objective discrepancies of sleep onset latency in patients with psychiatric disorders. Sci Rep 2023; 13: 22637. 20231219. DOI: 10.1038/s41598-023-49261-4.
    17. Kawai K, Iwamoto K, Miyata S, Okada I, Fujishiro H, Noda A, Nakagome K, Ozaki N and Ikeda M. Comparison of polysomnography, single-channel electroencephalogram, fitbit, and sleep logs in patients with psychiatric disorders: Cross-sectional study. J Med Internet Res 2023; 25: e51336. 20231213. DOI: 10.2196/51336.
    18. Kelsoe J, Ou A, Rosenthal S, Adli M, Akiyama K, Akula N, Alda M, Amare AT, Ardau R, Arias B, Aubry JM, Backlund L, Banzato C, Bauer M, Baune B, Bellivier F, Benabarre A, Bengesser S, Abesh B, Biernacka J, Bui E, Cervantes P, Chen GB, Chen HC, Chillotti C, Cichon S, Clark S, Colom F, Cousins D, Cruceanu C, Czerski P, Dantas C, Dayer A, Degenhardt F, DePaulo JR, Etain B, Falkai P, Fellendorf F, Ferensztajn-Rochowiak E, Forstner AJ, Frisen L, Frye M, Fullerton J, Gard S, Garnham J, Goes F, Grigoroiu-Serbanescu M, Grof P, Gruber O, Hashimoto R, Hauser J, Heilbronner U, Herms S, Hoffmann P, Hofmann A, Hou L, Jamain S, Jiménez E, Kahn JP, Kassem L, Kato T, Kittel-Schneider S, König B, Kuo PH, Kusumi I, Dalkner N, Laje G, Landén M, Lavebratt C, Leboyer M, Leckband S, Jaramillo CL, MacQueen G, Maj M, Manchia M, Marie-Claire C, Martinsson L, Mattheisen M, McCarthy M, McElroy S, McMahon F, Mitchell P, Mitjans M, Mondimore F, Monteleone P, Nievergelt C, Nöthen M, Novak T, Osby U, Ozaki N, Papiol S, Perlis R, Pfennig A, Potash J, Reich-Erkelenz D, Reif A, Reininghaus E, Rietschel M, Rouleau G, Rybakowski JK, Schalling M, Schofield P, Schubert KO, Schulze T, Schweizer B, Seemüller F, Severino G, Shekhtman T, Shilling P, Shimoda K, Simhandl C, Slaney C, Squassina A, Stamm T, Stopkova P, Tighe S, Tortorella A, Turecki G, Vieta E, Volkert J, Witt S, Wray N, Wright A, Young T, Zandi P and Zompo MD. Lithium response in bipolar disorder is associated with focal adhesion and pi3k-akt networks: A multi-omics replication study. Res Sq 2023 20231003. DOI: 10.21203/rs.3.rs-3258813/v1.
    19. Kimura H, Kishi S, Narita H, Tanaka T, Okada T, Fujisawa D, Sugita N, Noma S, Matsumoto Y, Ohashi A, Mitsuyasu H, Yoshida K, Kawasaki H, Nishimura K, Ogura Y and Ozaki N. Comorbid psychiatric disorders and long-term survival after liver transplantation in transplant facilities with a psychiatric consultation-liaison team: A multicenter retrospective study. BMC Gastroenterol 2023; 23: 106. 20230405. DOI: 10.1186/s12876-023-02735-1.
    20. Kimura H, Kushima I, Banno M, Inada T, Yoshimi A, Aleksic B and Ozaki N. Clinical characterization of patients with schizophrenia and 16p13.11 duplication: A case series. Neuropsychopharmacol Rep 2023; 43: 267-271. 20230428. DOI: 10.1002/npr2.12334.
    21. Kubota C, Inada T, Lin SK, Avasthi A, Chee KY, Tanra AJ, Yang SY, Chen LY, Chong MY, Tripathi A, Kallivayalil RA, Grover S, Park SC, Kato TA, Xiang YT, Sim K, Maramis MM, Noor IM, Tan CH, Sartorius N and Shinfuku N. The factor structure of extrapyramidal symptoms evaluated using the drug-induced extrapyramidal symptoms scale in patients with schizophrenia: Results from the 2016 reap ap-4 study. Hum Psychopharmacol 2023; 38: e2861. 20221203. DOI: 10.1002/hup.2861.
    22. Liao J, Dong G, Zhu W, Wulaer B, Mizoguchi H, Sawahata M, Liu Y, Kaibuchi K, Ozaki N, Nabeshima T, Nagai T and Yamada K. Rho kinase inhibitors ameliorate cognitive impairment in a male mouse model of methamphetamine-induced schizophrenia. Pharmacol Res 2023; 194: 106838. 20230628. DOI: 10.1016/j.phrs.2023.106838.
    23. Lo T, Kushima I, Aleksic B, Yoshimi A, Someya T, Watanabe Y and Ozaki N. Clinical manifestations of schizophrenia in four patients with variants in voltage-gated calcium channel-encoding genes: A case series. Psychiatry Clin Neurosci 2023; 77: 57-59. 20221109. DOI: 10.1111/pcn.13494.
    24. Lo T, Kushima I, Kimura H, Aleksic B, Okada T, Kato H, Inada T, Nawa Y, Torii Y, Yamamoto M, Kimura R, Funabiki Y, Kosaka H, Numata S, Kasai K, Sasaki T, Yokoyama S, Munesue T, Hashimoto R, Yasuda Y, Fujimoto M, Usami M, Itokawa M, Arai M, Ohi K, Someya T, Watanabe Y, Egawa J, Takahashi T, Suzuki M, Yamasue H, Iwata N, Ikeda M and Ozaki N. Association between copy number variations in parkin (prkn) and schizophrenia and autism spectrum disorder: A case-control study. Neuropsychopharmacol Rep 2024; 44: 42-50. 20231101. DOI: 10.1002/npr2.12370.
    25. Matsumoto J, Fukunaga M, Miura K, Nemoto K, Okada N, Hashimoto N, Morita K, Koshiyama D, Ohi K, Takahashi T, Koeda M, Yamamori H, Fujimoto M, Yasuda Y, Ito S, Yamazaki R, Hasegawa N, Narita H, Yokoyama S, Mishima R, Miyata J, Kobayashi Y, Sasabayashi D, Harada K, Yamamoto M, Hirano Y, Itahashi T, Nakataki M, Hashimoto RI, Tha KK, Koike S, Matsubara T, Okada G, Yoshimura R, Abe O, van Erp TGM, Turner JA, Jahanshad N, Thompson PM, Onitsuka T, Watanabe Y, Matsuo K, Yamasue H, Okamoto Y, Suzuki M, Ozaki N, Kasai K and Hashimoto R. Cerebral cortical structural alteration patterns across four major psychiatric disorders in 5549 individuals. Mol Psychiatry 2023; 28: 4915-4923. 20230818. DOI: 10.1038/s41380-023-02224-7.
    26. Miyake N, Tsurusaki Y, Fukai R, Kushima I, Okamoto N, Ohashi K, Nakamura K, Hashimoto R, Hiraki Y, Son S, Kato M, Sakai Y, Osaka H, Deguchi K, Matsuishi T, Takeshita S, Fattal-Valevski A, Ekhilevitch N, Tohyama J, Yap P, Keng WT, Kobayashi H, Takubo K, Okada T, Saitoh S, Yasuda Y, Murai T, Nakamura K, Ohga S, Matsumoto A, Inoue K, Saikusa T, Hershkovitz T, Kobayashi Y, Morikawa M, Ito A, Hara T, Uno Y, Seiwa C, Ishizuka K, Shirahata E, Fujita A, Koshimizu E, Miyatake S, Takata A, Mizuguchi T, Ozaki N and Matsumoto N. Molecular diagnosis of 405 individuals with autism spectrum disorder. Eur J Hum Genet 2024; 32: 1551-1558. 20230327. DOI: 10.1038/s41431-023-01335-7.
    27. Miyata S, Iwamoto K and Ozaki N. Evaluating sleep-wake rhythm using a wearable device in patients with mental disorders. Psychiatry Clin Neurosci 2023; 77: 419. 20230628. DOI: 10.1111/pcn.13568.
    28. Mizutani R, Saiga R, Yamamoto Y, Uesugi M, Takeuchi A, Uesugi K, Terada Y, Suzuki Y, De Andrade V, De Carlo F, Takekoshi S, Inomoto C, Nakamura N, Torii Y, Kushima I, Iritani S, Ozaki N, Oshima K, Itokawa M and Arai M. Structural aging of human neurons is opposite of the changes in schizophrenia. PLoS One 2023; 18: e0287646. 20230623. DOI: 10.1371/journal.pone.0287646.
    29. Nakagome K, Makinodan M, Uratani M, Kato M, Ozaki N, Miyata S, Iwamoto K, Hashimoto N, Toyomaki A, Mishima K, Ogasawara M, Takeshima M, Minato K, Fukami T, Oba M, Takeda K and Oi H. Feasibility of a wrist-worn wearable device for estimating mental health status in patients with mental illness. Front Psychiatry 2023; 14: 1189765. 20230720. DOI: 10.3389/fpsyt.2023.1189765.
    30. Ogasawara M, Takeshima M, Kosaka S, Imanishi A, Itoh Y, Fujiwara D, Yoshizawa K, Ozaki N, Nakagome K and Mishima K. Exploratory validation of sleep-tracking devices in patients with psychiatric disorders. Nat Sci Sleep 2023; 15: 301-312. 20230424. DOI: 10.2147/nss.S400944.
    31. Ohgidani M, Kushima I, Inamine S, Kyuragi S, Sagata N, Nakao T, Kanba S, Ozaki N and Kato TA. A case of bipolar disorder with aif1 (coding gene of iba-1) deletion: A pilot in vitro analysis using blood-derived microglia-like cells. Psychiatry Clin Neurosci 2023; 77: 128-130. 20221124. DOI: 10.1111/pcn.13505.
    32. Okada N, Fukunaga M, Miura K, Nemoto K, Matsumoto J, Hashimoto N, Kiyota M, Morita K, Koshiyama D, Ohi K, Takahashi T, Koeda M, Yamamori H, Fujimoto M, Yasuda Y, Hasegawa N, Narita H, Yokoyama S, Mishima R, Kawashima T, Kobayashi Y, Sasabayashi D, Harada K, Yamamoto M, Hirano Y, Itahashi T, Nakataki M, Hashimoto RI, Tha KK, Koike S, Matsubara T, Okada G, van Erp TGM, Jahanshad N, Yoshimura R, Abe O, Onitsuka T, Watanabe Y, Matsuo K, Yamasue H, Okamoto Y, Suzuki M, Turner JA, Thompson PM, Ozaki N, Kasai K and Hashimoto R. Subcortical volumetric alterations in four major psychiatric disorders: A mega-analysis study of 5604 subjects and a volumetric data-driven approach for classification. Mol Psychiatry 2023; 28: 5206-5216. 20230804. DOI: 10.1038/s41380-023-02141-9.
    33. Okuda M, Noda A, Iwamoto K, Hishikawa N, Miyata S, Yasuma F, Taoka T, Ozaki N, Suhr JA and Miyazaki S. Assessment of cognitive function and sleep-wake rhythms in community-dwelling older adults. Sleep Biol Rhythms 2024; 22: 137-145. 20230922. DOI: 10.1007/s41105-023-00491-z.
    34. Ozaki N, Kimura T, Kikuchi T and Ishiyama T. Neuropsychopharmacology renaissance in Japan: A new era after the crisis. Psychiatry Clin Neurosci 2023; 77: 375-376. 20230413. DOI: 10.1111/pcn.13549.
    35. Saito T, Ikeda M, Terao C, Ashizawa T, Miyata M, Tanaka S, Kanazawa T, Kato T, Kishi T and Iwata N. Differential genetic correlations across major psychiatric disorders between eastern and western countries. Psychiatry Clin Neurosci 2023; 77: 118-119. 20221117. DOI: 10.1111/pcn.13498.
    36. Sato-Boku A, Tokura T, Kimura H, Ito M, Kishi S, Tonoike T, Ozaki N, Nakano Y, Hosijima H and Tachi N. The usefulness of the short form-8 for chronic pain in the orofacial region: A prospective cohort study. Cureus 2023; 15: e45586. 20230920. DOI: 10.7759/cureus.45586.
    37. Senica N, Aleksic B, Inada T, Iljes AP, Zamuda T and Kumperscak HG. Slovenian version of the drug-induced extrapyramidal symptoms scale: Evaluation of interrater and test-retest reliability. J Clin Psychopharmacol 2023; 43: 361-364. 20230501. DOI: 10.1097/jcp.0000000000001682.
    38. Shimamoto M, Ishizuka K, Ohtani K, Inada T, Yamamoto M, Tachibana M, Kimura H, Sakai Y, Kobayashi K, Ozaki N and Ikeda M. Machine learning algorithm-based estimation model for the severity of depression assessed using montgomery-asberg depression rating scale. Neuropsychopharmacol Rep 2024; 44: 115-120. 20231220. DOI: 10.1002/npr2.12404.
    39. Suzuki K, Nishio N, Kimura H, Tokura T, Kishi S, Ozaki N, Fujimoto Y and Sone M. Comparison of quality of life and psychological distress in patients with tongue cancer undergoing a total/subtotal glossectomy or extended hemiglossectomy and free flap transfer: A prospective evaluation. Int J Oral Maxillofac Surg 2023; 52: 621-629. 20221202. DOI: 10.1016/j.ijom.2022.11.010.
    40. Tabata H, Mori D, Matsuki T, Yoshizaki K, Asai M, Nakayama A, Ozaki N and Nagata KI. Histological analysis of a mouse model of the 22q11.2 microdeletion syndrome. Biomolecules 2023; 13 20230427. DOI: 10.3390/biom13050763.
    41. Tachibana M and Inada T. Poor prognostic impact of delirium: Especially on mortality and institutionalisation. Psychogeriatrics 2023; 23: 187-195. 20221123. DOI: 10.1111/psyg.12914.
    42. Takahashi N, Nishimura T, Harada T, Okumura A, Iwabuchi T, Rahman MS, Kuwabara H, Takagai S, Usui N, Makinodan M, Matsuzaki H, Ozaki N, Itoh H, Nomura Y, Newcorn JH and Tsuchiya KJ. Interaction of genetic liability for attention deficit hyperactivity disorder (adhd) and perinatal inflammation contributes to adhd symptoms in children. Brain Behav Immun Health 2023; 30: 100630. 20230518. DOI: 10.1016/j.bbih.2023.100630.
    43. Tanaka R, Liao J, Hada K, Mori D, Nagai T, Matsuzaki T, Nabeshima T, Kaibuchi K, Ozaki N, Mizoguchi H and Yamada K. Inhibition of rho-kinase ameliorates decreased spine density in the medial prefrontal cortex and methamphetamine-induced cognitive dysfunction in mice carrying schizophrenia-associated mutations of the arhgap10 gene. Pharmacol Res 2023; 187: 106589. 20221130. DOI: 10.1016/j.phrs.2022.106589.
    44. Terashima A, Ogasawara K and Ozaki N. [psychotropic medication in pregnant and postpartum women]. Brain Nerve 2023; 75: 1043-1049. DOI: 10.11477/mf.1416202468.
    45. Torii Y, Iritani S, Fujishiro H, Sekiguchi H, Habuchi C, Ikeda T, Yoshida M, Iwasaki Y, Ozaki N and Kawashima K. An autopsy case of schizophrenia comorbid with argyrophilic grain disease. Psychogeriatrics 2023; 23: 371-373. 20230119. DOI: 10.1111/psyg.12935.
    46. Wada S, Iwamoto K, Okumura H, Hida H, Hiraoka S, Kamei A, Mori D, Yamada K and Ozaki N. Sensory evaluation of the bitterness of asenapine using d-sorbitol pretreatment: Single-blind, placebo-controlled, crossover trial. BMC Psychiatry 2023; 23: 159. 20230314. DOI: 10.1186/s12888-023-04664-5.
    47. Wada S, Ogasawara K and Ozaki N. [how to use psychotropic drugs during the perinatal period: Risks and benefits for fetuses and infants]. Brain Nerve 2023; 75: 645-651. DOI: 10.11477/mf.1416202392.
    48. Yamamoto H, Lee-Okada HC, Ikeda M, Nakamura T, Saito T, Takata A, Yokomizo T, Iwata N, Kato T and Kasahara T. Gwas-identified bipolar disorder risk allele in the fads1/2 gene region links mood episodes and unsaturated fatty acid metabolism in mutant mice. Mol Psychiatry 2023; 28: 2848-2856. 20230221. DOI: 10.1038/s41380-023-01988-2.
    49. Yamamoto M and Inada T. Positron emission tomography studies in adult patients with attention-deficit/hyperactivity disorder. Jpn J Radiol 2023; 41: 382-392. 20221208. DOI: 10.1007/s11604-022-01368-w.
  • 2022年
    1. Arafuka S, Fujishiro H, Iritani S, Torii Y, Miwa A, Yabata H, Sekiguchi H, Habuchi C, Kawashima K, Yoshida M, Iwasaki Y, Ozaki N. Striatal i-123-2 beta-carbomethoxy-3b-(4-iodophenyl)-n-(3-fluoropropyl)-nortropane single-photon emission computed tomography demonstrates nigral degeneration in the early stage of behavioural variant frontotemporal dementia: An autopsy case with frontotemporal lobar degeneration with trans-activation response DNA protein 43 type b. Psychogeriatrics. 2022;22(4):580-585.
    2. Arafuka S, Sekiguchi H, Fujishiro H, Iritani S, Torii Y, Habuchi C, Yoshida M, Iwasaki Y, Ozaki N, Fujita K. Late-onset panic disorder as the initial presentation in autopsy-confirmed dementia with lewy bodies. Psychiatry and Clinical Neurosciences. 2023;77(4):242-244.
    3. Fujishiro H, Arafuka S, Ogasawara K, Iwamoto K, Miyata S, Torii Y, Iritani S, Ozaki N. Temporal trajectories of proposed biomarkers in psychiatric-onset prodromal dementia with lewy bodies: A case report. Psychogeriatrics. 2023;23(1):196-200.
    4. Furuta S, Aleksic B, Nawa Y, Kimura H, Kushima I, Ishizuka K, Kato H, Toyama M, Arioka Y, Mori D, Morikawa M, Inada T, Ozaki N. Investigation of olig2 as a candidate gene for schizophrenia and autism spectrum disorder. Nagoya Journal of Medical Science. 2022;84(2):260-268.
    5. Hagikura M, Inada T. A case of schizophrenia with relapsed catatonia successfully treated with blonanserin transdermal patch. Neuropsychopharmacology Reports. 2023;43(1):150-153.
    6. Ishizuka K, Tachibana M, Inada T. Possible Commonalities of Clinical Manifestations Between Dystonia and Catatonia. Front Psychiatry. 2022;13:876678.
    7. Ito T, Yoshida M, Aida T, Kushima I, Hiramatsu Y, Ono M, Yoshimi A, Tanaka K, Ozaki N, Noda Y. Astrotactin 2 (astn2) regulates emotional and cognitive functions by affecting neuronal morphogenesis and monoaminergic systems. Journal of Neurochemistry. 2023;165(2):211-229.
    8. Kaminogo K, Yamaguchi S, Tokura T, Kimura H, Kishi S, Yamamoto N, Ozaki N, Hibi H. Coping styles and quality of life in oral cancer patients undergoing radical resection and free flap reconstruction. Oral Oncology Reports. 2023;5:100015.
    9. Kato S, Bagarinao E, Isoda H, Koyama S, Watanabe H, Maesawa S, Hara K, Katsuno M, Naganawa S, Ozaki N, Sobue G. Reproducibility of functional connectivity metrics estimated from resting-state functional mri with differences in days, coils, and global signal regression. Radiological Physics and Technology. 2022;15(4):298-310.
    10. Kawabata K, Bagarinaob E, Watanabe H, Maesawab S, Mori D, Hara K, Ohdake R, Masuda M, Ogura A, Kato T, Koyama S, Katsuno M, Wakabayashi T, Kuzuya M, Hoshiyama M, Isoda H, Naganawa S, Ozaki N, Sobue G. Functional connector hubs in the cerebellum. Neuroimage. 2022;257:119263.
    11. Kawai K, Iwamoto K, Miyata S, Okada I, Ando M, Fujishiro H, Noda A, Ozaki N. A Study of Factors Causing Sleep State Misperception in Patients with Depression. Nat Sci Sleep. 2022;14:1273-1283.
    12. Kawakami I, Iga JI, Takahashi S, Lin Y-T, Fujishiro H. Towards an understanding of the pathological basis of senile depression and incident dementia: implications for treatment. Psychiatry Clin Neurosci 2022;76(12):620-632.
    13. Kimura H, Nakatochi M, Aleksic B, Guevara J, Toyama M, Hayashi Y, Kato H, Kushima I, Morikawa M, Ishizuka K, Okada T, Tsurusaki Y, Fujita A, Miyake N, Ogi T, Takata A, Matsumoto N, Buxbaum J, Ozaki N, Sebat J. Exome sequencing analysis of japanese autism spectrum disorder case-control sample supports an increased burden of synaptic function-related genes. Translational Psychiatry. 2022;12(1):265.
    14. Kimura H, Yokoyama H, Torii Y, Fujishiro H. Electroconvulsive therapy as a potential therapeutic option in psychiatric-onset prodromal dementia with Lewy bodies. Int J Geriatr Psychiatry 2023; 38(1):e5863.
    15. Kubota C, Inada T, Lin SK, Avasthi A, Chee KY, Tanra AJ, Yang SY, Chen LY, Chong MY, Tripathi A, Kallivayalil RA, Grover S, Park SC, Kato TA, Xiang YT, Sim K, Maramis MM, Noor IM, Tan CH, Sartorius N, Shinfuku N. The factor structure of extrapyramidal symptoms evaluated using the drug-induced extrapyramidal symptoms scale in patients with schizophrenia: Results from the 2016 reap ap-4 study. Human Psychopharmacology-Clinical and Experimental. 2023;38(2):e2861.
    16. Kushima I, Aleksic B, Kimura H, Nakatochi M, Lo T, Ikeda M, Arai M, Hashimoto R, Numata S, Okamura Y, Obara T, Inada T, Ozaki N. X chromosome aneuploidies and schizophrenia: Association analysis and phenotypic characterization. Psychiatry and Clinical Neurosciences. 2022;76(12):667-673.
    17. Kushima I, Imaeda M, Tanaka S, Kato H, Oya-Ito T, Nakatochi M, Aleksic B, Ozaki N. Contribution of copy number variations to the risk of severe eating disorders. Psychiatry and Clinical Neurosciences. 2022;76(9):423-428.
    18. Kushima I, Nakatochi M, Aleksic B, Okada T, Kimura H, Kato H, Morikawa M, Inada T, Ishizuka K, Torii Y, Nakamura Y, Tanaka S, Imaeda M, Takahashi N, Yamamoto M, Iwamoto K, Nawa Y, Ogawa N, Iritani S, Hayashi Y, Lo TY, Otgonbayar G, Furuta S, Iwata N, Ikeda M, Saito T, Ninomiya K, Okochi T, Hashimoto R, Yamamori H, Yasuda Y, Fujimoto M, Miura K, Itokawa M, Arai M, Miyashita M, Toriumi K, Ohi K, Shioiri T, Kitaichi K, Someya T, Watanabe Y, Egawa J, Takahashi T, Suzuki M, Sasaki T, Tochigi M, Nishimura F, Yamasue H, Kuwabara H, Wakuda T, Kato TA, Kanba S, Horikawa H, Usami M, Kodaira M, Watanabe K, Yoshikawa T, Toyota T, Yokoyama S, Munesue T, Kimura R, Funabiki Y, Kosaka H, Jung MY, Kasai K, Ikegame T, Jinde S, Numata S, Kinoshita M, Kato T, Kakiuchi C, Yamakawa K, Suzuki T, Hashimoto N, Ishikawa S, Yamagata B, Nio S, Murai T, Son S, Kunii Y, Yabe H, Inagaki M, Goto YI, Okumura Y, Ito T, Arioka Y, Mori D, Ozaki N. Cross-disorder analysis of genic and regulatory copy number variations in bipolar disorder, schizophrenia, and autism spectrum disorder. Biological Psychiatry. 2022;92(5):362-374.
    19. Kushima I, Uematsu M, Ishizuka K, Aleksic B, Ozaki N. Psychiatric patients with a de novo 17q12 deletion: Two case reports. Psychiatry and Clinical Neurosciences. 2022;76(7):345-347.
    20. Lo T, Kushima I, Aleksic B, Kato H, Nawa Y, Hayashi Y, Otgonbayar G, Kimura H, Arioka Y, Mori D, Ozaki N. Sequencing of selected chromatin remodelling genes reveals increased burden of rare missense variants in asd patients from the japanese population. International Review of Psychiatry. 2022;34(2):154-167.
    21. Lo TY, Kushima I, Aleksic B, Yoshimi A, Someya T, Watanabe Y, Ozaki N. Clinical manifestations of schizophrenia in four patients with variants in voltage-gated calcium channel-encoding genes: A case series. Psychiatry and Clinical Neurosciences. 2023;77(1):57-59.
    22. Miyake N, Tsurusaki Y, Fukai R, Kushima I, Okamoto N, Ohashi K, Nakamura K, Hashimoto R, Hiraki Y, Son S, Kato M, Sakai Y, Osaka H, Deguchi K, Matsuishi T, Takeshita S, Fattal-Valevski A, Ekhilevitch N, Tohyama J, Yap P, Keng WT, Kobayashi H, Takubo K, Okada T, Saitoh S, Yasuda Y, Murai T, Nakamura K, Ohga S, Matsumoto A, Inoue K, Saikusa T, Hershkovitz T, Kobayashi Y, Morikawa M, Ito A, Hara T, Uno Y, Seiwa C, Ishizuka K, Shirahata E, Fujita A, Koshimizu E, Miyatake S, Takata A, Mizuguchi T, Ozaki N, Matsumoto N. Molecular diagnosis of 405 individuals with autism spectrum disorder. European Journal of Human Genetics. 2023.
    23. Miyata S, Otake H, Fujishiro H, Iwamo K, Noda A, Sone M, Ozaki N. Polysomnographic characteristics and predictors of positional obstructive sleep apnea in Japanese elderly. Sleep Biol. Rhythms. 2022;20:403-411.
    24. Mizobuchi K, Kushima I, Kato H, Miyajima M, Kimura H, Ozaki N. Turner syndrome presenting with idiopathic regression: A case report. Psychiatry and Clinical Neurosciences. 2022;76(12):680-682.
    25. Nawa Y, Kushima I, Aleksic B, Yamamoto M, Kimura H, Banno M, Hashimoto R, Ozaki N. Treatment-resistant schizophrenia in patients with 3q29 deletion: A case series of four patients. Psychiatry and Clinical Neurosciences. 2022;76(7):338-339.
    26. Nishimura T, Takahashi N, Okumura A, Harada T, Iwabuchi T, Nakayasu C, Rahman MS, Uchiyama S, Wakuta M, Nomura Y, Takei N, Senju A, Tsuchiya KJ. Sex differences in neurodevelopmental trajectories in children with different levels of autistic traits. Psychiatry Clin Neurosci. 2023;77(5):282-289.
    27. Nishimura T, Kato T, Okumura A, Harada T, Iwabuchi T, Rahman MS, Hirota T, Takahashi M, Adachi M, Kuwabara H, Takagai S, Nomura Y, Takahashi N, Senju A, Tsuchiya KJ. Trajectories of Adaptive Behaviors During Childhood in Females and Males in the General Population. Front Psychiatry. 2022;13:817383.
    28. Ogasawara M, Takeshima M, Kosaka S, Imanishi A, Itoh Y, Fujiwara D, Yoshizawa K, Ozaki N, Nakagome K, Mishima K. Exploratory validation of sleep-tracking devices in patients with psychiatric disorders. Nature and Science of Sleep. 2023;15:301-312.
    29. Oh HS, Lee BJ, Lee YS, Jang OJ, Nakagami Y, Inada T, Kato TA, Kanba S, Chong MY, Lin SK, Si TM, Xiang YT, Avasthi A, Grover S, Kallivayalil RA, Pariwatcharakul P, Chee KY, Tanra AJ, Rabbani G, Javed A, Kathiarachchi S, Myint WA, Cuong TV, Wang YX, Sim K, Sartorius N, Tan CH, Shinfuku N, Park YC, Park SC. Machine learning algorithm-based prediction model for the augmented use of clozapine with electroconvulsive therapy in patients with schizophrenia. Journal of Personalized Medicine. 2022;12(6):969.
    30. Oh J, Shin HM, Nishimura T, Rahman MS, Takahashi N, Tsuchiya KJ. Perfluorooctanoate and perfluorooctane sulfonate in umbilical cord blood and child cognitive development: Hamamatsu Birth Cohort for Mothers and Children (HBC Study). Environ Int. 2022;163:107215.
    31. Ohgidani M, Kushima I, Inamine S, Kyuragi S, Sagata N, Nakao T, Kanba S, Ozaki N, Kato TA. A case of bipolar disorder with aif1 (coding gene of iba-1) deletion: A pilot in vitro analysis using blood-derived microglia-like cells. Psychiatry and Clinical Neurosciences. 2023;77(2):128-130.
    32. Okada I, Miyata S, Iwamoto K, Fujishiro H, Noda A, Ozaki N. Prevalence of obstructive sleep apnea as assessed by polysomnography in psychiatric patients with sleep-related problems. Sleep Breath. 2022;26(4):1983-1991.
    33. Okumura H, Arioka Y, Kushima I, Mori D, Ozaki N. Establishment of induced pluripotent stem cells from a patient with 16p13.11 duplication and vps13b deletion. Stem Cell Research. 2022;64:102884.
    34. Sugiyama M, Tsuchiya KJ, Okubo Y, Rahman MS, Uchiyama S, Harada T, Iwabuchi T, Okumura A, Nakayasu C, Amma Y, Suzuki H, Takahashi N, Kinsella-Kammerer B, Nomura Y, Itoh H, Nishimura T. Outdoor Play as a Mitigating Factor in the Association Between Screen Time for Young Children and Neurodevelopmental Outcomes. JAMA Pediatr. 2023;177(3):303-310.
    35. sSumiyoshi C, Ohi K, Fujino H, Yamamori H, Fujimoto M, Yasuda Y, Uno Y, Takahashi J, Morita K, Katsuki A, Yamamoto M, Okahisa Y, Sata A, Katsumoto E, Koeda M, Hirano Y, Nakataki M, Matsumoto J, Miura K, Hashimoto N, Makinodan M, Takahashi T, Nemoto K, Kishimoto T, Suzuki M, Sumiyoshi T, Hashimoto R. Transdiagnostic comparisons of intellectual abilities and work outcome in patients with mental disorders: multicentre study. BJPsych Open. 2022;8(4):e98.
    36. Tachibana M, Inada T, Ichida M, Ozaki N. Prevalence, clinical features, and risk factors of delusions in patients with delirium. International Journal of Geriatric Psychiatry. 2022;37(6).
    37. Tachibana M, Inada T. Poor prognostic impact of delirium: especially on mortality and institutionalisation. Psychogeriatrics. 2023;23(1):187-195.
    38. Tachibana M, Ishizuka K, Inada T. Catatonia and Delirium: Similarity and Overlap of Acute Brain Dysfunction. Front Psychiatry. 2022;13:876727.
    39. Tainaka H, Takahashi N, Nishimura T, Okumura A, Harada T, Iwabuchi T, Rahman MS, Nomura Y, Tsuchiya KJ. Long-term effect of persistent postpartum depression on children's psychological problems in childhood. J Affect Disord. 2022;305:71-76.
    40. Takase S, Liao JZ, Liu Y, Tanaka R, Miyagawa Y, Sawahata M, Sobue A, Mizoguchi H, Nagai T, Kaibuchi K, Ozaki N, Yamada K. Antipsychotic-like effects of fasudil, a rho-kinase inhibitor, in a pharmacologic animal model of schizophrenia. European Journal of Pharmacology. 2022;931.
    41. Tanaka R, Liao JZ, Hada K, Mori D, Nagai T, Matsuzaki T, Nabeshima T, Kaibuchi K, Ozaki N, Mizoguchi H, Yamada K. Inhibition of rho-kinase ameliorates decreased spine density in the medial prefrontal cortex and methamphetamine-induced cognitive dysfunction in mice carrying schizophrenia-associated mutations of the arhgap10 gene. Pharmacological Research. 2023;187:106589.
    42. Torii Y, Iritani S, Fujishiro H, Sekiguchi H, Habuchi C, Ikeda T, Yoshida M, Iwasaki Y, Ozaki N, Kawashima K. An autopsy case of schizophrenia comorbid with pure argyrophilic grain disease. Psychogeriatrics 2023;23(2)371-373.
    43. Torii-Goto A, Yoshimi A, Tashiro Y, Ukigai M, Matsumoto A, Ozaki N, Noda Y. A reactive metabolite of clozapine induces hematopoietic toxicity in hl-60 cells undergoing granulocytic differentiation through its effect on glutathione metabolism. Biological & Pharmaceutical Bulletin. 2022;45(9):1232-1237.
    44. Tsujikawa K, Hamanaka K, Riku Y, Hattori Y, Hara N, Iguchi Y, Ishigaki S, Hashizume A, Miyatake S, Mitsuhashi S, Miyazaki Y, Kataoka M, Li JY, Yasui K, Kuru S, Koike H, Kobayashi K, Sahara N, Ozaki N, Yoshida M, Kakita A, Saito Y, Iwasaki Y, Miyashita A, Iwatsubo T, Ikeuchi T, Miyata T, Sobue G, Matsumoto N, Sahashi K, Katsuno M, Japanese Alzheimer's Dis N, Japanese Longitudinal Biomarker S. Actin-binding protein filamin-a drives tau aggregation and contributes to progressive supranuclear palsy pathology. Science Advances. 2022;8(21):eabm5029.
    45. Wada S, Iwamoto K, Okumura H, Hida H, Hiraoka S, Kamei A, Mori D, Yamada K, Ozaki N. Sensory evaluation of the bitterness of asenapine using d-sorbitol pretreatment: Single-blind, placebo-controlled, crossover trial. Bmc Psychiatry. 2023;23(1):159.
    46. Yamaguchi S, Kaminogo K, Tokura T, Kimura H, Kishi S, Yamamoto N, Ichimura N, Toyama N, Koma Y, Kouyama N, Ozaki N, Hibi H. Psychological impact on patients with oral cancer before undergoing resection and free flap reconstruction surgery. Oral Oncology Reports. 2022;3-4:100004.
    47. Yamamoto M, Bagarinao E, Shimamoto M, Iidaka T, Ozaki N. Involvement of cerebellar and subcortical connector hubs in schizophrenia. Neuroimage-Clinical. 2022;35:103140.
    48. Yamasue H, Kojima M, Kuwabara H, Kuroda M, Matsumoto K, Kanai C, Inada N, Owada K, Ochi K, Ono N, Benner S, Wakuda T, Kameno Y, Inoue J, Harada T, Tsuchiya K, Umemura K, Yamauchi A, Ogawa N, Kushima I, Ozaki N, Suyama S, Saito T, Uemura Y, Hamada J, Kano Y, Honda N, Kikuchi S, Seto M, Tomita H, Miyoshi N, Matsumoto M, Kawaguchi Y, Kanai K, Ikeda M, Nakamura I, Isomura S, Hirano Y, Onitsuka T, Kosaka H, Okada T. Effect of a novel nasal oxytocin spray with enhanced bioavailability on autism: A randomized trial. Brain. 2022;145(2):490-499.
    49. Yoshida M, Hasegawa S, Taniguchi M, Mouri A, Suzuki C, Yoshimi A, Mamiya T, Ozaki N, Noda Y. Memantine ameliorates the impairment of social behaviors induced by a single social defeat stress as juveniles. Neuropharmacology. 2022; 217:109208.
  • 2021年
    1. Amare AT, Schubert KO, Hou L, Clark SR, Papiol S, Cearns M, Heilbronner U, Degenhardt F, Tekola-Ayele F, Hsu YH, Shekhtman T, AdIi M, Akula N, Akiyama K, Ardau R, Arias B, Aubry JM, Backlund L, Bhattacharjee K, Bellivier F, Benabarre A, Bengesser S, Biernacka JM, Birner A, Brichant-Petitjean C, Cervantes P, Chen HC, Chillotti C, Cichon S, Cruceanu C, Czerski PM, Dalkner N, Dayer A, Del Zompo M, DePaulo JR, Etain B, Jamain S, Falkai P, Forstner AJ, Frisen L, Frye MA, Fullerton JM, Gard S, Garnham JS, Goes FS, Grigoroiu-Serbanescu M, Grof P, Hashimoto R, Hauser J, Herms S, Hoffmann P, Hofmann A, Jimenez E, Kahn JP, Kassem L, Kuo PH, Kato T, Kelsoe JR, Kittel-Schneider S, Kliwicki S, Konig B, Kusumi I, Laje G, Landen M, Lavebratt C, Leboyer M, Leckband SG, Tortorella A, Manchia M, Martinsson L, McCarthy MJ, McElroy SL, Colom F, Mitjans M, Mondimore FM, Monteleone P, Nievergelt CM, Nothen MM, Novak T, O'Donovan C, Ozaki N, Osby U, Pfennig A, Potash JB, Reif A, Reininghaus E, Rouleau GA, Rybakowski JK, Schalling M, Schofield PR, Schweizer BW, Severino G, Shilling PD, Shimoda K, Simhandl C, Slaney CM, Squassina A, Stamm T, Stopkova P, Maj M, Turecki G, Vieta E, Veeh J, Witt SH, Wright A, Zandi PP, Mitchell PB, Bauer M, Alda M, Rietschel M, McMahon FJ, Schulze TG, Baune BT, Psychiatric Genomics C. Association of polygenic score for major depression with response to lithium in patients with bipolar disorder. Molecular Psychiatry. 2021;26(6):2457-70.
    3. Arioka Y, Shishido E, Kushima I, Suzuki T, Saito R, Aiba A, Mori D, Ozaki N. Chromosome 22q11.2 deletion causes perk-dependent vulnerability in dopaminergic neurons. Ebiomedicine. 2021;63:103138.
    5. Arta RK, Watanabe Y, Inoue E, Nawa Y, Morikawa R, Egawa J, Kushima I, Igeta H, Hoya S, Sugimoto A, Tanra AJ, Ozaki N, Someya T. Resequencing and association analysis of gap43 with autism spectrum disorder and schizophrenia in a japanese population. Research in Autism Spectrum Disorders. 2021;82:101729.
    7. Fujishiro H, Torii Y, Iritani S, Ozaki N. Dopaminergic circuitry in late-life depression and lewy body disease. Psychiatry and Clinical Neurosciences. 2021;75(2):69-70.
    9. Hada K, Wulaer B, Nagai T, Itoh N, Sawahata M, Sobue A, Mizoguchi H, Mori D, Kushima I, Nabeshima T, Ozaki N, Yamada K. Mice carrying a schizophrenia-associated mutation of the arhgap10 gene are vulnerable to the effects of methamphetamine treatment on cognitive function: Association with morphological abnormalities in striatal neurons. Molecular Brain. 2021;14(1):1-17.
    11. Iino K, Toriumi K, Agarie R, Miyashita M, Suzuki K, Horiuchi Y, Niizato K, Oshima K, Imai A, Nagase Y, Kushima I, Koike S, Ikegame T, Jinde S, Nagata E, Washizuka S, Miyata T, Takizawa S, Hashimoto R, Kasai K, Ozaki N, Itokawa M, Arai M. Akr1a1 variant associated with schizophrenia causes exon skipping, leading to loss of enzymatic activity. Frontiers in Genetics. 2021;12.
    13. Ito M, Tokura T, Miyauchi T, Sato (Boku)　A, Kimura H, Tsuchihashi H, Katayama Y. Collaboration of perioperative management in an adult patient with 22 q 11.2 deletion syndrome: A case report. Clinical Case Reports. 2022;10(2):e05489.
    15. Ito T, Hiramatsu Y, Mouri A, Yoshigai T, Takahashi A, Yoshimi A, Mamiya T, Ozaki N, Noda Y. Involvement of pkcpi-sert activity in stress vulnerability of mice exposed to twice-swim stress. Neuroscience Research. 2021;171:83-91.
    17. Iwabuchi T, Takahashi N, Nishimura T, Rahman MS, Harada T, Okumura A, Kuwabara H, Takagai S, Nomura Y, Matsuzaki H, Ozaki N, Tsuchiya KJ. Affiliations expand. Associations Among Maternal Metabolic Conditions, Cord Serum Leptin Levels, and Autistic Symptoms in Children. Front Psychiatry. 2021;12:816196.
    19. Iwamoto K, Iwata M, Kambe D, Imadera Y, Tachibana N, Kajiyama Y, Ando M, Ozaki N. Residual effects of zopiclone on driving performance using a standardized driving simulator among healthy volunteers. Psychopharmacology (Berl). 2022;239(3):841-850.
    21. Iwata M, Iwamoto K, Kitajima I, Nogi T, Onishi K, Kajiyama Y, Nishino I, Ando M, Ozaki N. Validity and reliability of a driving simulator for evaluating the influence of medicinal drugs on driving performance. Psychopharmacology. 2021;238(3):775-86.
    23. Kato T, Nishimura T, Takahashi N, Harada T, Okumura A, Iwabuchi T, Nomura Y, Senju A, Tsuchiya KJ, Takei N. Identification of neurodevelopmental transition patterns from infancy to early childhood and risk factors predicting descending transition. Sci Rep. 2022;12:4822.
    25. Kato Y, Kuwabara H, Okada T, Munesue T, Benner S, Kuroda M, Kojima M, Yassin W, Eriguchi Y, Kameno Y, Murayama C, Nishimura T, Tsuchiya K, Kasai K, Ozaki N, Kosaka H, Yamasue H. Oxytocin-induced increase in n,n-dimethylglycine and time course of changes in oxytocin efficacy for autism social core symptoms. Molecular Autism. 2021;12(1):1-13.
    27. Kawabata K, Bagarinao E, Watanabe H, Maesawa S, Mori D, Hara K, Ohdake R, Masuda M, Ogura A, Kato T, Koyama S, Katsuno M, Wakabayashi T, Kuzuya M, Hoshiyama M, Isoda H, Naganawa S, Ozaki N, Sobue G. Bridging large-scale cortical networks: Integrative and function-specific hubs in the thalamus. Iscience. 2021;24(10):103106.
    29. Kimura H, Mori D, Aleksic B, Ozaki N. Elucidation of molecular pathogenesis and drug development for psychiatric disorders from rare disease-susceptibility variants. Neuroscience Research. 2021;170:24-31.
    31. Le Clerc S, Lombardi L, Baune BT, Amare AT, Schubert KO, Hou LP, Clark SR, Papiol S, Cearns M, Heilbronner U, Degenhardt F, Tekola-Ayele F, Hsu YH, Shekhtman T, Adli M, Akula N, Akiyama K, Ardau R, Arias B, Aubry JM, Backlund L, Bhattacharjee AK, Bellivier F, Benabarre A, Bengesser S, Biernacka JM, Birner A, Brichant-Petitjean C, Cervantes P, Chen HC, Chillotti C, Cichon S, Cruceanu C, Czerski PM, Dalkner N, Dayer A, Del Zompo M, DePaulo JR, Etain B, Jamain S, Falkai P, Forstner AJ, Frisen L, Frye MA, Fullerton JM, Gard S, Garnham JS, Goes FS, Grigoroiu-Serbanescu M, Grof P, Hashimoto R, Hauser J, Herms S, Hofmann P, Jimenez E, Kahn JP, Kassem L, Kuo PH, Kato T, Kelsoe JR, Kittel-Schneider S, Ferensztajn-Rochowiak E, Konig B, Kusumi I, Laje G, Landen M, Lavebratt C, Leckband S, Tortorella A, Manchia M, Martinsson L, McCarthy MJ, McElroy SL, Colom F, Millischer V, Mitjans M, Mondimore FM, Monteleone P, Nievergelt CM, Nothen MM, Novak T, O'Donovan C, Ozaki N, Osby U, Pfennig A, Potash JB, Reif A, Reininghaus E, Rouleau GA, Rybakowski JK, Schalling M, Schofeld PR, Schweizer BW, Severino G, Shilling PD, Shimoda K, Simhandl C, Slaney CM, Pisanu C, Squassina A, Stamm T, Stopkova P, Maj M, Turecki G, Vieta E, Veeh J, Witt SH, Wright A, Zandi PP, Mitchell PB, Bauer M, Alda M, Rietschel M, McMahon FJ, Schulze TG, Boukouaci W, Richard JR, Le Corvoisier P, Barrau C, Zagury JF, Leboyer M, Tamouza R. Hla-drb1 and hla-dqb1 genetic diversity modulates response to lithium in bipolar affective disorders. Scientific Reports. 2021;11(1):1-12.
    33. Lim K, Lam M, Zai C, Tay J, Karlsson N, Deshpande SN, Thelma BK, Ozaki N, Inada T, Sim K, Chong SA, Lencz T, Liu JJ, Lee J. Genome wide study of tardive dyskinesia in schizophrenia. Translational Psychiatry. 2021;11(1):1-10.
    35. Maesawa S, Mizuno S, Bagarinao E, Watanabe H, Kawabata K, Hara K, Ohdake R, Ogura A, Mori D, Nakatsubo D, Isoda H, Hoshiyama M, Katsuno M, Saito R, Ozaki N, Sobue G. Resting state networks related to the maintenance of good cognitive performance during healthy aging. Frontiers in Human Neuroscience. 2021;15:1-18.
    37. Miyata S, Iwamoto K, Banno M, Eguchi J, Kaneko S, Noda A, Ozaki N. Performance of an ambulatory electroencephalogram sleep monitor in patients with psychiatric disorders. Journal of Sleep Research. 2021;30(4):e13273.
    39. Mizutani R, Saiga R, Yamamoto Y, Uesugi M, Takeuchi A, Uesugi K, Terada Y, Suzuki Y, De Andrade V, De Carlo F, Takekoshi S, Inomoto C, Nakamura N, Torii Y, Kushima I, Iritani S, Ozaki N, Oshima K, Itokawa M, Arai M. Structural diverseness of neurons between brain areas and between cases. Translational Psychiatry. 2021;11(1): 1-9.
    41. Nakamura M, Yoshimi A, Mouri A, Tokura T, Kimura H, Kishi S, Miyauchi T, Iwamoto K, Ito M, Sato-Boku A, Ozaki N, Nabeshima T, Noda Y. Duloxetine attenuates pain in association with downregulation of platelet serotonin transporter in patients with burning mouth syndrome and atypical odontalgia. Human Psychopharmacology -Clinical and Experimental. 2022;7(2):e2818.
    43. Nakatochi M, Kushima I, Ozaki N. Implications of germline copy-number variations in psychiatric disorders: Review of large-scale genetic studies. Journal of Human Genetics. 2021;66(1):25-37.
    45. Nishida Y, Ikuta K, Natsume A, Ishihara N, Morikawa M, Kidokoro H, Muramatsu Y, Nonobe N, Ishizuka K, Takeichi T, Kanbe M, Mizuno S, Imagama S, Ozaki N. Establishment of in-hospital clinical network for patients with neurofibromatosis type 1 in nagoya university hospital. Scientific Reports. 2021;11(1): 1-7.
    47. Nishimura T, Kato T, Okumura A, Harada T, Iwabuchi T, Rahman MS, Hirota T, Takahashi M, Adachi M, Kuwabara H, Takagai S, Nomura Y, Takahashi N, Senju A, Tsuchiya KJ. Trajectories of Adaptive Behaviors During Childhood in Females and Males in the General Population. Front Psychiatry. 2022;13:817383.
    49. Nitta A, Izuo N, Hamatani K, Inagaki R, Kusui Y, Fu KQ, Asano T, Torii Y, Habuchi C, Sekiguchi H, Iritani S, Muramatsu S, Ozaki N, Miyamoto Y. Schizophrenia-like behavioral impairments in mice with suppressed expression of piccolo in the medial prefrontal cortex. Journal of Personalized Medicine. 2021;11(7):607.
    51. Noda Y, Soeda K, Uchida M, Goto S, Ito T, Kitagaki S, Mamiya T, Yoshimi A, Ozaki N, Mouri A. Multiple nicotinic acetylcholine receptor subtypes regulate social or cognitive behaviors in mice repeatedly administered phencyclidine. Behavioural Brain Research. 2021;408: 113284.
    53. Ogasawara K, Numata S, Hasegawa N, Nakataki,M, Makinodan M , Ohi K, Takeshima M, Tsuboi T, Hashimoto N, Onitsuka T, Muraoka H, Hori H, Ichihashi K, Inagaki T, Yasui-Furukori N, Hishimoto A, Sugiyama N, Fukumoto K, Nagasawa,T, Matsumoto J, Takaesu Y, Furihata,R, Nemoto K, Nakamura T, Usami M, Miura K, Fujimoto M, Tagata H, Yamada H, Komatsu H, Ochi S, Atake K, Katsumoto E, Kido M, Kishimoto T, Suwa T, Yamamura S, Iga J, Iida H, Inada K, Watanabe K, Hashimoto R. Subjective assessment of participants in education programs on clinical practice guidelines in the field of psychiatry. Neuropsychopharmacology Reports. 2022 Mar 10. doi: 10.1002/npr2.12245
    55. Oh J, Shin HM, Nishimura T, Rahman MS, Takahashi N, Tsuchiya KJ. Perfluorooctanoate and perfluorooctane sulfonate in umbilical cord blood and child cognitive development: Hamamatsu Birth Cohort for Mothers and Children (HBC Study). Environ Int. 2022;163:107215.
    57. Okada I, Iwamoto K, Miyata S, Fujimoto A, Tanaka M, Amano M, Matsuyama N, Taoka T, Naganawa S, Ozaki N. Fluid study: Study protocol for an open-label, single-centre pilot study to investigate the effect of lemborexant on sleep management in japanese subjects aged 50 years and older with insomnia disorder. Bmj Open. 2021;11(11): e054885.
    59. Okuda M, Noda A, Iwamoto K, Nakashima H, Takeda K, Miyata S, Yasuma F, Ozaki N, Shimouchi A. Effects of long sleep time and irregular sleep-wake rhythm on cognitive function in older people. Scientific Reports. 2021;11(1):1-10.
    61. Okuda M, Noda A, Mabuchi S, Iwamoto K, Banno M, Miyata S, Yasuma F, Ozaki N. Sleep fragmentation and working memory in healthy adults. Sleep Science. 2021;14:111-117.
    63. Rahman MS, Takahashi N, Iwabuchi T, Nishimura T, Harada T, Okumura A, Takei N, Nomura Y, Tsuchiya KJ. Elevated risk of attention deficit hyperactivity disorder (ADHD) in Japanese children with higher genetic susceptibility to ADHD with a birth weight under 2000 g. BMC Med. 2021;19:229.
    65. Saiga R, Uesugi M, Takeuchi A, Uesugi K, Suzuki Y, Takekoshi S, Inomoto C, Nakamura N, Torii Y, Kushima I, Iritani S, Ozaki N, Oshima K, Itokawa M, Arai M, Mizutani R. Brain capillary structures of schizophrenia cases and controls show a correlation with their neuron structures. Scientific Reports. 2021;11(1):1-9.
    67. Saito R, Miyoshi C, Koebis M, Kushima I, Nakao K, Mori D, Ozaki N, Funato H, Yanagisawa M, Aiba A. Two novel mouse models mimicking minor deletions in 22q11.2 deletion syndrome revealed the contribution of each deleted region to psychiatric disorders. Molecular Brain. 2021;14(1):1-15.
    69. Sato A, Kimura H, Tokura T, Umemura E, Miyauchi T, Ito M, Kishi S, Ogi N, Tonoike T, Ozaki N, Nakano Y, Okuda M. Evaluation of patients suffered from burning mouth syndrome and persistent idiopathic facial pain using japanese version paindetect questionnaire and depression scales. Journal of Dental Sciences. 2021;16(1):131-136.
    71. Sato M, Okada T, Morikawa M, Nakamura Y, Yamauchi A, Ando M, Ozaki N. Validation and factor analysis of the parental bonding instrument in japanese pregnant women. Scientific Reports. 2021;11(1):1-10.
    73. Schubert KO, Thalamuthu A, Amare AT, Frank J, Streit F, Adl M, Akula N, Akiyama K, Ardau R, Arias B, Aubry JM, Backlund L, Bhattacharjee AK, Bellivier F, Benabarre A, Bengesser S, Biernacka JM, Birner A, Marie-Claire C, Cearns M, Cervantes P, Chen HC, Chillotti C, Cichon S, Clark SR, Cruceanu C, Czerski PM, Dalkner N, Dayer A, Degenhardt F, Del Zompo M, DePaulo JR, Etain B, Falkai P, Forstner AJ, Frisen L, Frye MA, Fullerton JM, Gard S, Garnham JS, Goes FS, Grigoroiu-Serbanescu M, Grof P, Hashimoto R, Hauser J, Heilbronner U, Herms S, Hoffmann P, Hou LP, Hsu YH, Jamain S, Jimenez E, Kahn JP, Kassem L, Kuo PH, Kato T, Kelsoe J, Kittel-Schneider S, Ferensztajn-Rochowiak E, Konig B, Kusumi I, Laje G, Landen M, Lavebratt C, Leboyer M, Leckband SG, Maj M, Manchia M, Martinsson L, McCarthy MJ, McElroy S, Colom F, Mitjans M, Mondimore FM, Monteleone P, Nievergelt CM, Nothen MM, Novak T, O'Donovan C, Ozaki N, Osby U, Papiol S, Pfennig A, Pisanu C, Potash JB, Reif A, Reininghaus E, Rouleau GA, Rybakowski JK, Schalling M, Schofield PR, Schweizer BW, Severino G, Shekhtman T, Shilling PD, Shimoda K, Simhandl C, Slaney CM, Squassina A, Stamm T, Stopkova P, Tekola-Ayele F, Tortorella A, Turecki G, Veeh J, Vieta E, Witt SH, Roberts G, Zandi PP, Alda M, Bauer M, McMahon FJ, Mitchell PB, Schulze TG, Rietschel M, Baune BT, Psychiat Genomics C. Combining schizophrenia and depression polygenic risk scores improves the genetic prediction of lithium response in bipolar disorder patients. Translational Psychiatry. 2021;11(1):1-8.
    75. Sekiguchi H, Fujishiro H, Torii Y, Iritani S, Ozaki N. Can we identify prodromal dementia with lewy bodies in late-life depression? Psychiatry and Clinical Neurosciences. 2021;75(3):113-114.
    77. Shizuku M, Kimura H, Kamei H, Kishi S, Tokura T, Kurata N, Jobara K, Yoshizawa A, Tsuboi C, Yamaguchi N, Kato M, Kawai K, Yamashiki M, Kanai E, Ishizuka K, Ozaki N, Ogura Y. Psychosocial characteristics of alcoholic and non-alcoholic liver disease recipient candidates in liver transplantation: A prospective observational study. Bmc Gastroenterology. 2021;21(1):1-10.
    79. Stone W, Nunes A, Akiyama K, Akula N, Ardau R, Aubry JM, Backlund L, Bauer M, Bellivier F, Cervantes P, Chen HC, Chillotti C, Cruceanu C, Dayer A, Degenhardt F, Del Zompo M, Forstner AJ, Frye M, Fullerton JM, Grigoroiu-Serbanescu M, Grof P, Hashimoto R, Hou LP, Jimenez E, Kato T, Kelsoe J, Kittel-Schneider S, Kuo PH, Kusumi I, Lavebratt C, Manchia M, Martinsson L, Mattheisen M, McMahon FJ, Millischer V, Mitchell PB, Nothen MM, O'Donovan C, Ozaki N, Pisanu C, Reif A, Rietschel M, Rouleau G, Rybakowski J, Schalling M, Schofield PR, Schulze TG, Severino G, Squassina A, Veeh J, Vieta E, Trappenberg T, Alda M. Prediction of lithium response using genomic data. Scientific Reports. 2021;11(1):1-10.
    81. Tachibana M, Inada T, Ichida M, Kojima S, Arai T, Naito K, Ozaki N. Significant decrease in delirium referrals after changing hypnotic from benzodiazepine to suvorexant. Psychogeriatrics. 2021;21(3):324-332.
    83. Tachibana M, Inada T, Ichida M, Kojima S, Shioya M, Wakayama K, Ozaki N. Factors associated with the severity of delirium. Human Psychopharmacology-Clinical and Experimental. 2021;36(5):e2787.
    85. Tachibana M, Inada T, Ichida M, Ozaki N. Risk factors for inducing violence in patients with delirium. Brain and Behavior. 2021;11(8):e2276.
    87. Tachibana M, Inada T, Ichida M, Ozaki N. Factors affecting hallucinations in patients with delirium. Scientific Reports. 2021;11(1):1-6.
    89. Takahashi N, Okumura A, Nishimura T, Harada T, Iwabuchi T, Rahman MS, Tsuchiya KJ. Exploration of Sleep Parameters, Daytime Hyperactivity/Inattention, and Attention-Deficit/Hyperactivity Disorder Polygenic Risk Scores of Children in a Birth Cohort in Japan. JAMA Netw Open. 2022;5:e2141768.
    91. Takahashi N, Nishimura T, Harada T, Okumura A, Iwabuchi T, Rahman MS, Kuwabara H, Takagai S, Nomura Y, Takei N, Tsuchiya KJ. Association Between Genetic Risks for Obesity and Working Memory in Children. Front Neurosci. 2021;15:749230.
    93. Takahashi N, Ishizuka K, Inada T. Peripheral biomarkers of attention-deficit hyperactivity disorder: Current status and future perspective. J Psychiatr Res. 2021;137:465-70.
    95. Tsuneura Y, Sawahata M, Itoh N, Miyajima R, Mori D, Kohno T, Hattori M, Sobue A, Nagai T, Mizoguchi H, Nabeshima T, Ozaki N, Yamada K. Analysis of reelin signaling and neurodevelopmental trajectory in primary cultured cortical neurons with reln deletion identified in schizophrenia. Neurochemistry International. 2021;144:104954.
    97. Uchida M, Noda Y, Hasegawa S, Hida H, Taniguchi M, Mouri A, Yoshimi A, Nabeshima T, Yamada K, Aida T, Tanaka K, Ozaki N. Early postnatal inhibition of glast causes abnormalities of psychobehaviors and neuronal morphology in adult mice. Neurochemistry International. 2021;150:105177.
    99. Yoshikawa A, Kushima I, Miyashita M, Toriumi K, Suzuki K, Horiuchi Y, Kawaji H, Takizawa S, Ozaki N, Itokawa M, Arai M. Dysregulation of post-transcriptional modification by copy number variable micrornas in schizophrenia with enhanced glycation stress. Translational Psychiatry. 2021;11(1):1-11.
  • ～2020年
    1. Amare AT, Schubert KO, Hou L, Clark SR, Papiol S, Cearns M, Heilbronner U, Degenhardt F, Tekola-Ayele F, Hsu YH, Shekhtman T, Adli M, Akula N, Akiyama K, Ardau R, Arias B, Aubry JM, Backlund L, Bhattacharjee AK, Bellivier F, Benabarre A, Bengesser S, Biernacka JM, Birner A, Brichant-Petitjean C, Cervantes P, Chen HC, Chillotti C, Cichon S, Cruceanu C, Czerski PM, Dalkner N, Dayer A, Del Zompo M, DePaulo JR, Étain B, Jamain S, Falkai P, Forstner AJ, Frisen L, Frye MA, Fullerton JM, Gard S, Garnham JS, Goes FS, Grigoroiu-Serbanescu M, Grof P, Hashimoto R, Hauser J, Herms S, Hoffmann P, Hofmann A, Jiménez E, Kahn JP, Kassem L, Kuo PH, Kato T, Kelsoe JR, Kittel-Schneider S, Kliwicki S, König B, Kusumi I, Laje G, Landén M, Lavebratt C, Leboyer M, Leckband SG, Tortorella A, Manchia M, Martinsson L, McCarthy MJ, McElroy SL, Colom F, Mitjans M, Mondimore FM, Monteleone P, Nievergelt CM, Nöthen MM, Novák T, O'Donovan C, Ozaki N, Ösby U, Pfennig A, Potash JB, Reif A, Reininghaus E, Rouleau GA, Rybakowski JK, Schalling M, Schofield PR, Schweizer BW, Severino G, Shilling PD, Shimoda K, Simhandl C, Slaney CM, Squassina A, Stamm T, Stopkova P, Maj M, Turecki G, Vieta E, Veeh J, Witt SH, Wright A, Zandi PP, Mitchell PB, Bauer M, Alda M, Rietschel M, McMahon FJ, Schulze TG, Baune BT. Association of polygenic score for major depression with response to lithium in patients with bipolar disorder. Molecular psychiatry. 2020. https://doi.org/10.1038/s41380-020-0689-5
    2. Arioka Y, Hirata A, Kushima I, Aleksic B, Mori D, Ozaki N. Characterization of a schizophrenia patient with a rare reln deletion by combining genomic and patient-derived cell analyses. Schizophrenia research. 2020;216:511-5.
    3. Arioka Y, Shishido E, Kushima I, Mori D, Ozaki N. Cell body shape and directional movement stability in human-induced pluripotent stem cell-derived dopaminergic neurons. Scientific reports. 2020;10(1):5820.
    4. Bagarinao E, Watanabe H, Maesawa S, Mori D, Hara K, Kawabata K, Ohdake R, Masuda M, Ogura A, Kato T, Koyama S, Katsuno M, Wakabayashi T, Kuzuya M, Hoshiyama M, Isoda H, Naganawa S, Ozaki N, Sobue G. Identifying the brain's connector hubs at the voxel level using functional connectivity overlap ratio. NeuroImage. 2020;222:117241.
    5. Bagarinao E, Watanabe H, Maesawa S, Mori D, Hara K, Kawabata K, Yoneyama N, Ohdake R, Imai K, Masuda M, Yokoi T, Ogura A, Taoka T, Koyama S, Tanabe HC, Katsuno M, Wakabayashi T, Kuzuya M, Hoshiyama M, Isoda H, Naganawa S, Ozaki N, Sobue G. Aging impacts the overall connectivity strength of regions critical for information transfer among brain networks. Frontiers in aging neuroscience. 2020;12:592469.
    6. Choy SW, Bagarinao E, Watanabe H, Ho ETW, Maesawa S, Mori D, Hara K, Kawabata K, Yoneyama N, Ohdake R, Imai K, Masuda M, Yokoi T, Ogura A, Taoka T, Koyama S, Tanabe HC, Katsuno M, Wakabayashi T, Kuzuya M, Hoshiyama M, Isoda H, Naganawa S, Ozaki N, Sobue G. Changes in white matter fiber density and morphology across the adult lifespan: A cross-sectional fixel-based analysis. Human brain mapping. 2020;41(12):3198-211.
    7. Ishizuka K, Yoshida T, Kawabata T, Imai A, Mori H, Kimura H, Inada T, Okahisa Y, Egawa J, Usami M, Kushima I, Morikawa M, Okada T, Ikeda M, Branko A, Mori D, Someya T, Iwata N, Ozaki N. Functional characterization of rare nrxn1 variants identified in autism spectrum disorders and schizophrenia. Journal of neurodevelopmental disorders. 2020;12(1):25.
    8. Ito T, Hiramatsu Y, Uchida M, Yoshimi A, Mamiya T, Mouri A, Ozaki N, Noda Y. Involvement of protein kinase c beta1-serotonin transporter system dysfunction in emotional behaviors in stressed mice. Neurochemistry international. 2020;140:104826.
    9. Ito Y, Maesawa S, Bagarinao E, Okai Y, Nakatsubo D, Yamamoto H, Kidokoro H, Usui N, Natsume J, Hoshiyama M, Wakabayashi T, Sobue G, Ozaki N. Subsecond eeg-fmri analysis for presurgical evaluation in focal epilepsy. Journal of neurosurgery. 2020:1-10.
    10. Itokawa M, Oshima K, Arai M, Torii Y, Kushima I, Iritani S, Ozaki N, Saiga R, Mizutani R. Cutting-edge morphological studies of post-mortem brains of patients with schizophrenia and potential applications of x-ray nanotomography (nano-ct). Psychiatry and clinical neurosciences. 2020;74(3):176-82.
    11. Kato K, Noda A, Yasuma F, Matsubara Y, Miyata S, Iwamoto K, Miyazaki S, Ozaki N. Effects of sleep-disordered breathing and hypertension on cognitive function in elderly adults. Clinical and experimental hypertension (New York, NY : 1993). 2020;42(3):250-6.
    12. Kato S, Bagarinao E, Isoda H, Koyama S, Watanabe H, Maesawa S, Mori D, Hara K, Katsuno M, Hoshiyama M, Naganawa S, Ozaki N, Sobue G. Effects of head motion on the evaluation of age-related brain network changes using resting state functional mri. Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine. 2020.
    13. Kimura H, Mori D, Aleksic B, Ozaki N. Elucidation of molecular pathogenesis and drug development for psychiatric disorders from rare disease-susceptibility variants. Neuroscience research. 2020.
    14. Koshiyama D, Fukunaga M, Okada N, Morita K, Nemoto K, Usui K, Yamamori H, Yasuda Y, Fujimoto M, Kudo N, Azechi H, Watanabe Y, Hashimoto N, Narita H, Kusumi I, Ohi K, Shimada T, Kataoka Y, Yamamoto M, Ozaki N, Okada G, Okamoto Y, Harada K, Matsuo K, Yamasue H, Abe O, Hashimoto R, Takahashi T, Hori T, Nakataki M, Onitsuka T, Holleran L, Jahanshad N, van Erp TGM, Turner J, Donohoe G, Thompson PM, Kasai K, Hashimoto R. White matter microstructural alterations across four major psychiatric disorders: Mega-analysis study in 2937 individuals. Molecular psychiatry. 2020;25(4):883-95.
    15. Kubota C, Inada T, Nakamura Y, Shiino T, Ando M, Aleksic B, Yamauchi A, Morikawa M, Okada T, Ohara M, Sato M, Murase S, Goto S, Kanai A, Ozaki N. Validation and factor structure of the japanese version of the inventory to diagnose depression, lifetime version for pregnant women. PloS one. 2020;15(6):e0234240.
    16. Kubota C, Inada T, Shiino T, Ando M, Sato M, Nakamura Y, Yamauchi A, Morikawa M, Okada T, Ohara M, Aleksic B, Murase S, Goto S, Kanai A, Ozaki N. The risk factors predicting suicidal ideation among perinatal women in japan. Frontiers in psychiatry. 2020;11:441.
    17. Lim ET, Uddin M, De Rubeis S, Chan Y, Kamumbu AS, Zhang X, D'Gama AM, Kim SN, Hill RS, Goldberg AP, Poultney C, Minshew NJ, Kushima I, Aleksic B, Ozaki N, Parellada M, Arango C, Penzol MJ, Carracedo A, Kolevzon A, Hultman CM, Weiss LA, Fromer M, Chiocchetti AG, Freitag CM, Church GM, Scherer SW, Buxbaum JD, Walsh CA. Publisher correction: Rates, distribution and implications of postzygotic mosaic mutations in autism spectrum disorder. Nature neuroscience. 2020;23(9):1176.
    18. Miyata S, Iwamoto K, Banno M, Eguchi J, Kaneko S, Noda A, Ozaki N. Performance of an ambulatory electroencephalogram sleep monitor in patients with psychiatric disorders. Journal of sleep research. 2020:e13273.
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    463. Deng X, Shibata H, Takeuchi N, Rachi S, Sakai M, Ninomiya H, Iwata N, Ozaki N, Fukumaki Y. Association study of polymorphisms in the glutamate transporter genes SLC1A1, SLC1A3, and SLC1A6 with schizophrenia. Am J Med Genet B Neuropsychiatr Genet, 2007; 144: 271-278.
    464. Aleksic B, Ishihara R, Takahashi N, Maeno N, Ji X, Saito S, Inada T, Ozaki N. Gap junction coding genes and schizophrenia: a genetic association study. J Hum Genet, 2007; 52: 498-501.
    465. Usui H, Takahashi N, Saito S, Ishihara R, Aoyama N, Ikeda M, Suzuki T, Kitajima T, Yamanouchi Y, Kinoshita Y, Yoshida K, Iwata N, Inada T, Ozaki N. The 2',3'-cyclic nucleotide 3'-phosphodiesterase and oligodendrocyte lineage transcription factor 2 genes do not appear to be associated with schizophrenia in the Japanese population. Schizophr Res, 2006; 88: 245-250.
    466. Ujike H, Sakai A, Nakata K, Tanaka Y, Kodaka T, Okahisa Y, Harano M, Inada T, Yamada M, Komiyama T, Hori T, Sekine Y, Iwata N, Sora I, Iyo M, Ozaki N, Kuroda S. Association Study of the Dihydropyrimidinase-Related Protein 2 Gene and Methamphetamine Psychosis. Ann N Y Acad Sci, 2006; 1074: 90-96.
    467. Takahashi N, Ishihara R, Saito S, Maemo N, Aoyama N, Ji X, Miura H, Ikeda M, Iwata N, Suzuki T, Kitajima T, Yamanouchi Y, Kinoshita Y, Ozaki N, Inada T. Association between chromogranin A gene polymorphism and schizophrenia in the Japanese population. Schizophr Res, 2006; 83: 179-183.
    468. Suzuki A, Nakamura K, Sekine Y, Minabe Y, Takei N, Suzuki K, Iwata Y, Kawai M, Takebayashi K, Matsuzaki H, Iyo M, Ozaki N, Inada T, Iwata N, Harano M, Komiyama T, Yamada M, Sora I, Ujike H, Mori N. An association study between catechol-O-methyl transferase gene polymorphism and methamphetamine psychotic disorder. Psychiatr Genet, 2006; 16: 133-138.
    469. Shibata H, Aramaki T, Sakai M, Ninomiya H, Tashiro N, Iwata N, Ozaki N, Fukumaki Y. Association study of polymorphisms in the GluR7, KA1 and KA2 kainate receptor genes (GRIK3, GRIK4, GRIK5) with schizophrenia. Psychiatry Res, 2006; 141: 39-51.
    470. Okada T, Sato W, Toichi M. Right hemispheric dominance in gaze-triggered reflexive shift of attention in humans. Brain Cogn, 2006; 62: 128-133.
    471. Nomura A, Ujike H, Tanaka Y, Otani K, Morita Y, Kishimoto M, Morio A, Harano M, Inada T, Yamada M, Komiyama T, Sekine Y, Iwata N, Sora I, Iyo M, Ozaki N, Kuroda S. Genetic variant of prodynorphin gene is risk factor for methamphetamine dependence. Neurosci Lett, 2006; 400: 158-162.
    472. Nomura A, Ujike H, Tanaka Y, Kishimoto M, Otani K, Morita Y, Morio A, Harano M, Inada T, Yamada M, Komiyama T, Hori T, Sekine Y, Iwata N, Sora I, Iyo M, Ozaki N, Kuroda S. Association Study of the Tumor Necrosis Factor-{alpha} Gene and Its 1A Receptor Gene with Methamphetamine Dependence. Ann N Y Acad Sci, 2006; 1074: 116-124.
    473. Noda A, Nakai S, Soga T, Sugiura T, Iwayama N, Maeda K, Atarashi M, Yasuma F, Ozaki N, Yokota M, Koike Y. Factors contributing to sleep disturbance and hypnotic drug use in hemodialysis patients. Intern Med, 2006; 45: 1273-1278.
    474. Nakamura K, Chen CK, Sekine Y, Iwata Y, Anitha A, Loh el W, Takei N, Suzuki A, Kawai M, Takebayashi K, Suzuki K, Minabe Y, Tsuchiya K, Yamada K, Iyo M, Ozaki N, Inada T, Iwata N, Harano M, Komiyama T, Yamada M, Sora I, Ujike H, Ball DM, Yoshikawa T, Lin SK, Mori N. Association analysis of SOD2 variants with methamphetamine psychosis in Japanese and Taiwanese populations. Hum Genet, 2006; 120: 243-252.
    475. Nakajima A, Kamitsuji S, Saito A, Tanaka E, Nishimura K, Horikawa N, Ozaki N, Tomatsu T, Hara M, Kamatani N, Yamanaka H. Disability and patient's appraisal of general health contribute to depressed mood in rheumatoid arthritis in a large clinical study in Japan. Mod Rheumatol, 2006; 16: 151-157.
    476. Morio A, Ujike H, Nomura A, Tanaka Y, Morita Y, Otani K, Kishimoto M, Harano M, Inada T, Komiyama T, Yamada M, Sekine Y, Iwata N, Iyo M, Sora I, Ozaki N, Kuroda S. No Association between CART (Cocaine- and Amphetamine-Regulated Transcript) Gene and Methamphetamine Dependence. Ann N Y Acad Sci, 2006; 1074: 411-417.
    477. Masui T, Hashimoto R, Kusumi I, Suzuki K, Tanaka T, Nakagawa S, Suzuki T, Iwata N, Ozaki N, Kato T, Kunugi H, Koyama T. Lithium response and Val66Met polymorphism of the brain-derived neurotrophic factor gene in Japanese patients with bipolar disorder. Psychiatr Genet, 2006; 16: 49-50.
    478. Kobayashi H, Hata H, Ujike H, Harano M, Inada T, Komiyama T, Yamada M, Sekine Y, Iwata N, Iyo M, Ozaki N, Itokawa M, Naka M, Ide S, Ikeda K, Numachi Y, Sora I. Association analysis of delta-opioid receptor gene polymorphisms in methamphetamine dependence/psychosis. Am J Med Genet B Neuropsychiatr Genet, 2006; 141: 482-486.
    479. Kishi T, Ikeda M, Suzuki T, Kitajima T, Yamanouchi Y, Kinoshita Y, Ozaki N, Iwata N. No association of complexin1 and complexin2 genes with schizophrenia in a Japanese population. Schizophr Res, 2006; 82: 185-189.
    480. Kimura H, Ozaki N. Diagnosis and treatment of depression in dialysis patients. Ther Apher Dial, 2006; 10: 328-332.
    481. Ikeda M, Iwata N, Suzuki T, Kitajima T, Yamanouchi Y, Kinoshiya Y, Sekine Y, Iyo M, Harano M, Komiyama T, Yamada M, Sora I, Ujike H, Inada T, Ozaki N. Positive association of AKT1 haplotype to Japanese methamphetamine use disorder. Int J Neuropsychopharmacol, 2006; 9: 77-81.
    482. Ikeda M, Iwata N, Suzuki T, Kitajima T, Yamanouchi Y, Kinoshita Y, Ozaki N. No association of serotonin transporter gene (SLC6A4) with schizophrenia and bipolar disorder in Japanese patients: association analysis based on linkage disequilibrium. J Neural Transm, 2006; 113: 899-905.
    483. Ikeda M, Iwata N, Kitajima T, Suzuki T, Yamanouchi Y, Kinoshita Y, Ozaki N. Positive association of the serotonin 5-HT7 receptor gene with schizophrenia in a Japanese population. Neuropsychopharmacology, 2006; 31: 866-871.
    484. Iidaka T, Matsumoto A, Ozaki N, Suzuki T, Iwata N, Yamamoto Y, Okada T, Sadato N. Volume of left amygdala subregion predicted temperamental trait of harm avoidance in female young subjects. A voxel-based morphometry study. Brain Res, 2006; 1125: 85-93.
    485. Ide S, Kobayashi H, Ujike H, Ozaki N, Sekine Y, Inada T, Harano M, Komiyama T, Yamada M, Iyo M, Iwata N, Tanaka K, Shen H, Iwahashi K, Itokawa M, Minami M, Satoh M, Ikeda K, Sora I. Linkage disequilibrium and association with methamphetamine dependence/psychosis of mu-opioid receptor gene polymorphisms. Pharmacogenomics J, 2006; 6: 179-188.
    486. Hashimoto R, Numakawa T, Ohnishi T, Kumamaru E, Yagasaki Y, Ishimoto T, Mori T, Nemoto K, Adachi N, Izumi A, Chiba S, Noguchi H, Suzuki T, Iwata N, Ozaki N, Taguchi T, Kamiya A, Kosuga A, Tatsumi M, Kamijima K, Weinberger DR, Sawa A, Kunugi H. Impact of the DISC1 Ser704Cys polymorphism on risk for major depression, brain morphology and ERK signaling. Hum Mol Genet, 2006; 15: 3024-3033.
    487. Hakamata Y, Iwase M, Iwata H, Kobayashi T, Tamaki T, Nishio M, Kawahara K, Matsuda H, Ozaki N, Honjo S, Inada T. Regional brain cerebral glucose metabolism and temperament: a positron emission tomography study. Neurosci Lett, 2006; 396: 33-37.
    488. Aoyama N, Takahashi N, Saito S, Maeno N, Ishihara R, Ji X, Miura H, Ikeda M, Suzuki T, Kitajima T, Yamanouchi Y, Kinoshita Y, Yoshida K, Iwata N, Inada T, Ozaki N. Association study between kynurenine 3-monooxygenase gene and schizophrenia in the Japanese population. Genes Brain Behav, 2006; 5: 364-368.
    489. Aoyama N, Takahashi N, Kitaichi K, Ishihara R, Saito S, Maeno N, Ji X, Takagi K, Sekine Y, Iyo M, Harano M, Komiyama T, Yamada M, Sora I, Ujike H, Iwata N, Inada T, Ozaki N. Association between gene polymorphisms of SLC22A3 and methamphetamine use disorder. Alcohol Clin Exp Res, 2006; 30: 1644-1649.
    490. Ando T, Komaki G, Naruo T, Okabe K, Takii M, Kawai K, Konjiki F, Takei M, Oka T, Takeuchi K, Masuda A, Ozaki N, Suematsu H, Denda K, Kurokawa N, Itakura K, Yamaguchi C, Kono M, Suzuki T, Nakai Y, Nishizono-Maher A, Koide M, Murakami K, Nagamine K, Tomita Y, Ookuma K, Tomita K, Tonai E, Ooshima A, Ishikawa T, Ichimaru Y. Possible role of preproghrelin gene polymorphisms in susceptibility to bulimia nervosa. Am J Med Genet B Neuropsychiatr Genet, 2006; 141: 929-934.
    491. Saito S, Ikeda M, Iwata N, Suzuki T, Kitajima T, Yamanouchi Y, Kinoshita Y, Takahashi N, Inada T, Ozaki N. No association was found between a functional SNP in ZDHHC8 and schizophrenia in a Japanese case-control population. Neurosci Lett, 2005; 374: 21-24.
    492. Ohgake S, Hashimoto K, Shimizu E, Koizumi H, Okamura N, Koike K, Matsuzawa D, Sekine Y, Inada T, Ozaki N, Iwata N, Harano M, Komiyama T, Yamada M, Sora I, Ujike H, Shirayama Y, Iyo M. Functional polymorphism of the NQO2 gene is associated with methamphetamine psychosis. Addict Biol, 2005; 10: 145-148.
    493. Nishiyama T, Ikeda M, Iwata N, Suzuki T, Kitajima T, Yamanouchi Y, Sekine Y, Iyo M, Harano M, Komiyama T, Yamada M, Sora I, Ujike H, Inada T, Furukawa T, Ozaki N. Haplotype association between GABAA receptor gamma2 subunit gene (GABRG2) and methamphetamine use disorder. Pharmacogenomics J, 2005; 5: 89-95.
    494. Morita Y, Ujike H, Tanaka Y, Uchida N, Nomura A, Otani K, Kishimoto M, Morio A, Inada T, Harano M, Komiyama T, Yamada M, Sekine Y, Iwata N, Iyo M, Sora I, Ozaki N. The X-box binding protein 1 (XBP1) gene is not associated with methamphetamine dependence. Neurosci Lett, 2005; 383: 194-198.
    495. Morita Y, Ujike H, Tanaka Y, Uchida N, Nomura A, Ohtani K, Kishimoto M, Morio A, Imamura T, Sakai A, Inada T, Harano M, Komiyama T, Yamada M, Sekine Y, Iwata N, Iyo M, Sora I, Ozaki N, Kuroda S. A nonsynonymous polymorphism in the human fatty acid amide hydrolase gene did not associate with either methamphetamine dependence or schizophrenia. Neurosci Lett, 2005; 376: 182-187.
    496. Miura H, Qiao H, Kitagami T, Ohta T, Ozaki N. Fluvoxamine, a selective serotonin reuptake inhibitor, suppresses tetrahydrobiopterin levels and dopamine as well as serotonin turnover in the mesoprefrontal system of mice. Psychopharmacology (Berl), 2005; 177: 307-314.
    497. Miura H, Qiao H, Kitagami T, Ohta T, Ozaki N. Effects of fluvoxamine on levels of dopamine, serotonin, and their metabolites in the hippocampus elicited by isolation housing and novelty stress in adult rats. Int J Neurosci, 2005; 115: 367-378.
    498. Maeno N, Kusunoki K, Kitajima T, Iwata N, Ono Y, Hashimoto S, Imai M, Li L, Kayukawa Y, Ohta T, Ozaki N. Personality of seasonal affective disorder analyzed by Tri-dimensional Personality Questionnaire. J Affect Disord, 2005; 85: 267-273.
    499. Kinoshita Y, Suzuki T, Ikeda M, Kitajima T, Yamanouchi Y, Inada T, Yoneda H, Iwata N, Ozaki N. No association with the calcineurin A gamma subunit gene (PPP3CC) haplotype to Japanese schizophrenia. J Neural Transm, 2005; 112: 1255-1262.
    500. Ikeda M, Iwata N, Suzuki T, Kitajima T, Yamanouchi Y, Kinoshita Y, Ozaki N. No association of GSK3beta gene (GSK3B) with Japanese schizophrenia. Am J Med Genet B Neuropsychiatr Genet, 2005; 134: 90-92.
    501. Ikeda M, Iwata N, Suzuki T, Kitajima T, Yamanouchi Y, Kinoshita Y, Inada T, Ujike H, Ozaki N. Association Analysis of Chromosome 5 GABA(A) Receptor Cluster in Japanese Schizophrenia Patients. Biol Psychiatry, 2005; 58: 440-445.
    502. Ikeda M, Iwata N, Suzuki T, Kitajima T, Yamanouchi Y, Kinoshita Y, Inada T, Ozaki N. No association of haplotype-tagging SNPs in TRAR4 with schizophrenia in Japanese patients. Schizophr Res, 2005; 78: 127-130.
    503. Iidaka T, Ozaki N, Matsumoto A, Nogawa J, Kinoshita Y, Suzuki T, Iwata N, Yamamoto Y, Okada T, Sadato N. A variant C178T in the regulatory region of the serotonin receptor gene HTR3A modulates neural activation in the human amygdala. J Neurosci, 2005; 25: 6460-6466.
    504. Hashimoto T, Hashimoto K, Matsuzawa D, Shimizu E, Sekine Y, Inada T, Ozaki N, Iwata N, Harano M, Komiyama T, Yamada M, Sora I, Ujike H, Iyo M. A functional glutathione S-transferase P1 gene polymorphism is associated with methamphetamine-induced psychosis in Japanese population. Am J Med Genet B Neuropsychiatr Genet, 2005; 135B: 5-9.
    505. Hashimoto R, Yoshida M, Ozaki N, Yamanouchi Y, Iwata N, Suzuki T, Kitajima T, Tatsumi M, Kamijima K, Kunugi H. A missense polymorphism (H204R) of a Rho GTPase-activating protein, the chimerin 2 gene, is associated with schizophrenia in men. Schizophr Res, 2005; 73: 383-385.
    506. Hashimoto R, Suzuki T, Iwata N, Yamanouchi Y, Kitajima T, Kosuga A, Tatsumi M, Ozaki N, Kamijima K, Kunugi H. Association study of the frizzled-3 (FZD3) gene with schizophrenia and mood disorders. J Neural Transm, 2005; 112: 303-307.
    507. Hakamata Y, Takahashi N, Ishihara R, Saito S, Ozaki N, Honjo S, Ono Y, Inada T. No association between monoamine oxidase A promoter polymorphism and personality traits in Japanese females. Neurosci Lett, 2005; 389: 121-123.
    508. Furukawa TA, Streiner DL, Azuma H, Higuchi T, Kamijima K, Kanba S, Ozaki N, Aoba A, Murasaki M, Miura S. Cross-cultural equivalence in depression assessment: Japan-Europe-North American study. Acta Psychiatr Scand, 2005; 112: 279-285.
    509. Arinami T, Ohtsuki T, Ishiguro H, Ujike H, Tanaka Y, Morita Y, Mineta M, Takeichi M, Yamada S, Imamura A, Ohara K, Shibuya H, Suzuki Y, Muratake T, Kaneko N, Someya T, Inada T, Yoshikawa T, Toyota T, Yamada K, Kojima T, Takahashi S, Osamu O, Shinkai T, Nakamura M, Fukuzako H, Hashiguchi T, Niwa SI, Ueno T, Tachikawa H, Hori T, Asada T, Nanko S, Kunugi H, Hashimoto R, Ozaki N, Iwata N, Harano M, Arai H, Ohnuma T, Kusumi I, Koyama T, Yoneda H, Fukumaki Y, Shibata H, Kaneko S, Higuchi H, Yasui-Furukori N, Numachi Y, Itokawa M, Okazaki Y. Genomewide high-density SNP linkage analysis of 236 Japanese families supports the existence of schizophrenia susceptibility Loci on chromosomes 1p, 14q, and 20p. Am J Hum Genet, 2005; 77: 937-944.
    510. Arima M, Shimizu Y, Sowa J, Narita T, Nishi I, Iwata N, Ozaki N, Hashimoto S, Matsunaga K. Psychosomatic analysis of atopic dermatitis using a psychological test. J Dermatol, 2005; 32: 160-168.
    511. Takano A, Uchiyama M, Kajimura N, Mishima K, Inoue Y, Kamei Y, Kitajima T, Shibui K, Katoh M, Watanabe T, Hashimotodani Y, Ozeki Y, Hori T, Yamada N, Toyoshima R, Ozaki N, Okawa M, Nagai K, Takahashi K, Isojima Y, Yamauchi T, Ebisawa T. A Missense Variation in Human Casein Kinase I Epsilon Gene that Induces Functional Alteration and Shows an Inverse Association with Circadian Rhythm Sleep Disorders. Neuropsychopharmacology, 2004; 29: 1901-1909.
    512. Ozaki N. Pharmacogenetics of antipsychotics. Nagoya J Med Sci, 2004; 67: 1-7.
    513. Okada M, Northup J, Ozaki N, Russell J, Linnoila M, Goldman D. Modification of Human 5-HT2C Receptor Function by Cys23Ser, an Abundant, Naturally Occurring Amino Acid Substitution. Mol Psychiatry, 2004; 9: 55-64.
    514. Okada M, Goldman D, Linnoila M, Iwata N, Ozaki N, Northup JK. Comparison of G-Protein Selectivity of Human 5-HT2C and 5-HT1A Receptors. Ann N Y Acad Sci, 2004; 1025: 570-577.
    515. Numakawa T, Yagasaki Y, Ishimoto T, Okada T, Suzuki T, Iwata N, Ozaki N, Taguchi T, Tatsumi M, Kamijima K, Straub RE, Weinberger DR, Kunugi H, Hashimoto R. Evidence of novel neuronal functions of dysbindin, a susceptibility gene for schizophrenia. Hum Mol Genet, 2004; 13: 2699-2708.
    516. Nokura K, Kanbayashi T, Ozeki T, Koga H, Zettsu T, Yamamoto H, Ozaki N, Shimizu T, Kawase T. Hypersomnia, asterixis and cataplexy in association with orexin A-reduced hypothalamic tumor. J Neurol, 2004; 251: 1534-1535.
    517. Munakata K, Tanaka M, Mori K, Washizuka S, Yoneda M, Tajima O, Akiyama T, Nanko S, Kunugi H, Tadokoro K, Ozaki N, Inada T, Sakamoto K, Fukunaga T, Iijima Y, Iwata N, Tatsumi M, Yamada K, Yoshikawa T, Kato T. Mitochondrial DNA 3644T-->C mutation associated with bipolar disorder. Genomics, 2004; 84: 1041-1050.
    518. Kunugi H, Iijima Y, Tatsumi M, Yoshida M, Hashimoto R, Kato T, Sakamoto K, Fukunaga T, Inada T, Suzuki T, Iwata N, Ozaki N, Yamada K, Yoshikawa T. No association between the Val66Met polymorphism of the brain-derived neurotrophic factor gene and bipolar disorder in a Japanese population: a multicenter study. Biol Psychiatry, 2004; 56: 376-378.
    519. Koizumi H, Hashimoto K, Kumakiri C, Shimizu E, Sekine Y, Ozaki N, Inada T, Harano M, Komiyama T, Yamada M, Sora I, Ujike H, Takei N, Iyo M. Association between the glutathione S-transferase M1 gene deletion and female methamphetamine abusers. Am J Med Genet, 2004; 126B: 43-45.
    520. Kobayashi H, Ide S, Hasegawa J, Ujike H, Sekine Y, Ozaki N, Inada T, Harano M, Komiyama T, Yamada M, Iyo M, Shen HW, Ikeda K, Soraa I. Study of Association between {alpha}-Synuclein Gene Polymorphism and Methamphetamine Psychosis/Dependence. Ann N Y Acad Sci, 2004; 1025: 325-334.
    521. Iwata N, Suzuki T, Ikeda M, Kitajima T, Yamanouchi Y, Inada T, Ozaki N. No Association With the Neuregulin 1 Haplotype to Japanese Schizophrenia. Mol Psychiatry, 2004; 9: 126-127.
    522. Iwata N, Inada T, Harano M, Komiyama T, Yamada M, Sekine Y, Iyo M, Sora I, Ujike H, Ozaki N. No association is found between the candidate genes of t-PA/plasminogen system and Japanese methamphetamine-related disorder: a collaborative study by the Japanese Genetics Initiative for Drug Abuse. Ann N Y Acad Sci, 2004; 1025: 34-38.
    523. Itoh K, Hashimoto K, Shimizu E, Sekine Y, Ozaki N, Inada T, Harano M, Iwata N, Komiyama T, Yamada M, Sora I, Nakata K, Ujike H, Iyo M. Association study between brain-derived neurotrophic factor gene polymorphisms and methamphetamine abusers in Japan. Am J Med Genet B Neuropsychiatr Genet, 2004; 132B: 70-73.
    524. Inada T, Iijima Y, Uchida N, Maeda T, Iwashita S, Ozaki N, Harano M, Komiyama T, Yamada M, Sekine Y, Iyo M, Sora I, Ujikec H. No Association Found between the Type 1 Sigma Receptor Gene Polymorphisms and Methamphetamine Abuse in the Japanese Population: A Collaborative Study by the Japanese Genetics Initiative for Drug Abuse. Ann N Y Acad Sci, 2004; 1025: 27-33.
    525. Ikeda M, Iwata N, Suzuki T, Kitajima T, Yamanouchi Y, Kinoshita Y, Inada T, Ozaki N. Association of AKT1 with schizophrenia confirmed in a Japanese population. Biol Psychiatry, 2004; 56: 698-700.
    526. Ide S, Kobayashi H, Tanaka K, Ujike H, Sekine Y, Ozaki N, Inada T, Harano M, Komiyama T, Yamada M, Iyo M, Ikeda K, Sora I. Gene polymorphisms of the mu opioid receptor in methamphetamine abusers. Ann N Y Acad Sci, 2004; 1025: 316-324.
    527. Hashimoto R, Yoshida M, Ozaki N, Yamanouchi Y, Iwata N, Suzuki T, Kitajima T, Tatsumi M, Kamijima K, Kunugi H. Association analysis of the -308G>A promoter polymorphism of the tumor necrosis factor alpha (TNF-alpha) gene in Japanese patients with schizophrenia. J Neural Transm, 2004; 111: 217-221.
    528. Harano M, Uchimura N, Abe H, Ishibashi M, Iida N, Yanagimoto K, Tanaka T, Maeda H, Sora I, Iyo M, Komiyama T, Yamada M, Sekine Y, Inada T, Ozaki N, Ujike H. A Polymorphism of DRD2 Gene and Brain Atrophy in Methamphetamine Psychosis. Ann N Y Acad Sci, 2004; 1025: 307-315.
    529. Deng XX, Shibata HH, Ninomiya HH, Tashiro NN, Iwata NN, Ozaki NN, Fukumaki YY. Association study of polymorphisms in the excitatory amino acid transporter 2 gene (SLC1A2) with schizophrenia. BMC Psychiatry, 2004; 4: 21.
    530. Yamanouchi Y, Iwata N, Suzuki T, Kitajima T, Ikeda M, Ozaki N. Effect of DRD2, 5-HT2A, and COMT genes on antipsychotic response to risperidone. Pharmacogenomics J, 2003; 3: 356-361.
    531. Ujike H, Harano M, Inada T, Yamada M, Komiyama T, Sekine Y, Sora I, Iyo M, Katsu T, Nomura A, Nakata K, Ozaki N. Nine- or fewer repeat alleles in VNTR polymorphism of the dopamine transporter gene is a strong risk factor for prolonged methamphetamine psychosis. Pharmacogenomics J, 2003; 3: 242-247.
    532. Tokura T, Murase T, Toriyama T, Totani Y, Negita M, Akaza K, Ozawa H, Nakagawa A, Nakamura S. Asian variant of CD5+ intravascular large B-cell lymphoma with splenic infarction. Intern Med, 2003; 42: 105-109.
    533. Suzuki T, Iwata N, Kitamura Y, Kitajima T, Yamanouchi Y, Ikeda M, Nishiyama T, Kamatani N, Ozaki N. Association of a haplotype in the serotonin 5-HT4 receptor gene (HTR4) with Japanese schizophrenia. Am J Med Genet B Neuropsychiatr Genet, 2003; 121: 7-13.
    534. Ozaki N, Goldman D, Kaye WH, Plotnicov K, Greenberg BD, Lappalainen J, Rudnick G, Murphy DL. Serotonin transporter missense mutation associated with a complex neuropsychiatric phenotype. Mol Psychiatry, 2003; 8: 933-936.
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    536. Okada T, Toichi M, Sakihama M. Influences of an anticholinergic antiparkinsonian drug, parkinsonism, and psychotic symptoms on cardiac autonomic function in schizophrenia. J Clin Psychopharmacol, 2003; 23: 441-447.
    537. Okada M, Irie S, Sawada M, Urae R, Urae A, Iwata N, Ozaki N, Akazawa K, Nakanishi H. Pepstatin A induces extracellular acidification distinct from aspartic protease inhibition in microglial cell lines. Glia, 2003; 43: 167-174.
    538. Noda M, Yasuda S, Okada M, Higashida H, Shimada A, Iwata N, Ozaki N, Nishikawa K, Shirasawa S, Uchida M, Aoki S, Wada K. Recombinant human serotonin 5A receptors stably expressed in C6 glioma cells couple to multiple signal transduction pathways. J Neurochem, 2003; 84: 222-232.
    539. Kusunoki K, Kitajima T, Ozaki N. Does quazepam influence sleep and daytime activity in healthy adults? Sleep and Biological Rhythms, 2003; 1: 171-172.
    540. Kubota Y, Querel C, Pelion F, Laborit J, Laborit MF, Gorog F, Okada T, Murai T, Sato W, Yoshikawa S, Toichi M, Hayashi T. Facial affect recognition in pre-lingually deaf people with schizophrenia. Schizophr Res, 2003; 61: 265-270.
    541. Toichi M, Kamio Y, Okada T, Sakihama M, Youngstrom EA, Findling RL, Yamamoto K. A lack of self-consciousness in autism. Am J Psychiatry, 2002; 159: 1422-1424.
    542. Sato W, Kubota Y, Okada T, Murai T, Yoshikawa S, Sengoku A. Seeing happy emotion in fearful and angry faces: qualitative analysis of facial expression recognition in a bilateral amygdala-damaged patient. Cortex, 2002; 38: 727-742.
    543. Iwase T, Kajimura N, Uchiyama M, Ebisawa T, Yoshimura K, Kamei Y, Shibui K, Kim K, Kudo Y, Katoh M, Watanabe T, Nakajima T, Ozeki Y, Sugishita M, Hori T, Ikeda M, Toyoshima R, Inoue Y, Yamada N, Mishima K, Nomura M, Ozaki N, Okawa M, Takahashi K, Yamauchi T. Mutation screening of the human Clock gene in circadian rhythm sleep disorders. Psychiatry Res, 2002; 109: 121-128.
    544. Hirano S, Sato T, Narita T, Kusunoki K, Ozaki N, Kimura S, Takahashi T, Sakado K, Uehara T. Evaluating the state dependency of the Temperament and Character Inventory dimensions in patients with major depression: a methodological contribution. J Affect Disord, 2002; 69: 31-38.

研究キーワード

児童思春期精神医学、 統合失調症、 うつ病、 双極性障害、 認知症、 自閉スペクトラム症、 不安症、 身体症状症、 周産期、 産業衛生医学、 歯科口腔外科学、 がん、 臓器移植、 心不全、 オミックス、 ゲノム、 モデル動物、 iPS細胞、 神経画像、 死後脳、 疼痛、 向精神薬、 エピゲノム

精神医学／発達老年医学／親と子どもの心療学　独自ホームページ

糖鎖生命コア研究所　iGCORE

精神医学　オープンキャンパス

大学院の概要；研究と教育の基本方針

精神疾患の病態メカニズムを解明する研究や、臨床実践に基づいた研究を行っています。これらの研究は、すぐに新薬の開発に直結するわけではありませんが、将来的により良い治療法の確立や、薬物の副作用による社会生活への支障を解消するためには欠かせません。そのため、「より質の高いエビデンス」を構築することを推進しています。

文献検索や批判的な吟味、研究デザイン、実験ノートの書き方、データ解析、データの提示方法、サイエンティフィックライティングといった、研究を進める上で必要となる基本的な技術を習得し、将来の研究活動の基盤を築くだけでなく、臨床の場でも活用できる科学的視点を養えるよう指導しています。

また、医学部卒業生に限らず、心理学関連の学科や薬学部、保健学部など、他分野を卒業した方々の参加も歓迎しています。

研究に専念する博士課程の大学院生としての進学と、基幹施設や連携施設で精神科医としての業務を継続しながら社会人大学院生として学び続ける選択肢があります。

教育・研修についてはこちらもご参照ください。