研究室紹介LABORATORY

臨床感染統御学（［病］中央感染制御部）

KEYWORDS

  • 薬剤耐性菌
  • 病院疫学
  • 感染対策
  • 抗菌薬適正使用
  • リアルワールドデータ
  • ウイルス感染症  

HEAD

八木 哲也

教授

研究者総覧

LAB MEMBER

構成員名 役職 研究者総覧
森岡 悠 講師 研究者総覧
岡 圭輔 助教 研究者総覧
奥村 俊彦 病院助教 研究者総覧

CONTACT

Email med◎t.mail.nagoya-u.ac.jp（送信の際は◎を@に変更してください）
HP 臨床感染統御学 ([病]中央感染制御部) 独自ホームページ

OUTLINE

構成員は現在、教授1名、教官3名、医員3名（内、大学院生1名）からなっている。基礎研究としては、病院内感染症やその病原微生物（特に薬剤耐性グラム陰性桿菌）の疫学、感染対策・治療についての研究に加え、新生児集中治療室におけるウイルス感染症のサーベイランスとゲノムタイピングも行っている。臨床研究としては、横断的疫学研究を多施設で実施し、病院内感染対策や抗菌薬適正使用の推進に活用している。現在、外来抗菌薬の投与状況の多施設調査・周術期抗菌薬などのリアルワールドデータの解析を行っている。

RESEARCH PROJECTS

1. 医療関連感染症、抗微生物薬処方に関する疫学研究

i) 入院患者の横断的疫学調査
我が国で初めて、感染制御のために「Point Prevalence Survey（PPS）」を導入し、院内感染症及び抗菌薬の使用状況について調査を行った。2016年に4大学病院における多施設調査後、愛知県の27病院(10199人)の患者を対象に行ったPPSでは、医療関連感染症の有病率は6.6%（デバイス関連感染症は0.91%）、抗微生物薬が全入院患者の29.6%に使用されていることが明らかになった。また、本研究では、愛知県での周術期抗菌薬投与の実態調査、小児における抗微生物薬投与の疫学も報告している。これらの結果は、国内で最大の病院疫学データであり、院内感染対策の改善と抗菌薬の適正使用に寄与している。今後は、愛知県のみならず、全国でPPSを行う予定である。

infectious-dis_Figure_1.png
病床別での医療関連感染症の有病率

infectious-dis_Figure_2.png
抗微生物薬使用の75%を占める薬剤とその適応

ii) 周術期抗菌薬に関する研究
周術期における抗菌薬使用の問題点を特定するため、2018年に16の大学病院で688人の患者を対象に周術期抗菌薬の使用状況を調査した。調査結果、全体の46.8%の患者に対してガイドラインに沿った投与が行われていたが、手術分野・施設によって適正使用率に大きな差が見られた。現在、リアルワールドデータを用いた周術期抗菌薬の有効性評価の研究を行っている。

iii) 外来での抗菌薬処方に関する研究
2024年度中には愛知県内の感染対策向上加算1を取得した34病院で、2987人を対象に調査を実施し、抗菌薬が不適正に処方される状況を調査した。今後は、リアルワールドデータを用いた外来抗菌薬投与の現状も調査する予定である。

 2. 薬剤耐性グラム陰性桿菌の解析

i) Carbapenem-resistant Enterobacterales（カルバペネム耐性腸内細菌目細菌：CRE）の解析
CREの蔓延は世界的な脅威となりつつあり、我が国でもサーベイランスが開始された。当研究室では、CREに有効な感染対策や治療法についての研究、当院及び地域でのサーベイランスで検出されたCRE分離株の薬剤耐性機序、菌の分子疫学的解析などの研究を行っている。
国公立大学医学部附属病院感染対策協議会で収集したCRE分離株の解析を行い、死亡に関連する因子の検索や、耐性遺伝子や検出菌種についての解析を行った。
近隣の施設内でアウトブレイクが示唆されるCREについて、菌株の分子疫学的解析を実施している。
まれなカルバペネマーゼ産生菌について、次世代シーケンサーによる解析を行っている。

ii) Extended-spectrum β-lactamase (ESBL) 産生Klebsiella pneumoniaeの分子疫学的研究
ESBL産生Klebsiella pneumoniaeは大腸菌と比較して分離頻度は高くなく、分子疫学的情報も少ない。現在当研究室では、九州大学、旭川医科大学と共同で、ESBL産生K. pneumoniaeの産生するESBLの解析及び菌の分子疫学的・遺伝学的解析を行った。保有するESBL遺伝子やキノロン耐性遺伝子は、3カ所の地域で異なっていた。

infectious-dis_Figure_3.png
ESBL産生Klebsiella pneumoniaeの分布に関するクラスター分析。

数字は配列型（ST）を示す。円の大きさは株数を示す。円の色は検出された大学を示す。
青は名古屋大学医学部附属病院、緑は旭川医科大学病院、赤は九州大学病院。

iii)  Enterobacter cloacae complexの分子疫学・耐性機構および臨床像に関する研究
Enterobacter cloacae complexは、臨床的には尿路感染症や腹腔内感染症などの原因菌であり、ESBL産生やAmpC型βラクタマーゼ過剰産生による耐性化が問題となる。Enterobacter cloacae complexは様々な亜種の菌の集合体であり、その亜種によって耐性遺伝子の型や耐性化の頻度、臨床経過の違いを、多施設から菌株を収集し解析する。

3. 感染症マネジメント支援システムの開発(島津製作所との共同研究)

感染症診療に関する相談やり取りを効率化することで感染症専門医へのアクセスを改善させ、より早期の治療方針決定に貢献することで、感染症治療成績を向上させることを目的としたWeb上のコミュニケーションシステムを開発した。
＜詳細はリンク先を参照＞産学連携による 日本初の「感染症マネジメント支援システム」の開発～「ニーズ探索型研究」により見出された課題解決成果～
(https://www.med.nagoya-u.ac.jp/medical_J/news/news/post_133.html)
インタビュー記事「現場ニーズが生んだ「感染症マネジメント支援システム」、もうすぐ始動！」（名大研究フロントライン）(https://note.com/nagoya_ura/n/n6bd82d3554e5)

4. 手洗いシンクの排水管を対象とした院内環境由来の感染制御に関する研究

病院における手洗いシンク由来感染症の制御を目的として、シンク表面および排水管内の菌叢解析を行っている。排水管内の細菌汚染に対しては、モレーンコーポレーションが開発した排水管加熱装置「ドレインポッド」を用い、既存配管における細菌量低減効果、堆積物の解析、排水管の構造への影響および安全性について検証している。培養法、全ゲノム解析、内視鏡観察などを組み合わせ、実臨床に即した院内環境由来の感染制御を目指した研究を進めている。

infectious-dis_Figure_4.png
病院内の手洗いシンク排水管に対する排水管加熱装置による除菌効果の検証

既存の排水管における細菌のコロニー形成を著しく減少させた。
抗菌効果は継続使用においても持続していた。

5. 手指衛生評価システムを用いたアルコール手指消毒量の最適化研究

病院における手指衛生の質向上を目的として、モレーンコーポレーションが開発した手指衛生評価システム「HandWe!」を用いた研究を行っている。感染対策に関わる看護師と連携し、アルコール手指消毒薬の使用量と、塗布範囲・手指の大きさとの関係を定量的に評価し、最適な使用量の検証を行っている。実践可能かつ科学的根拠に基づいた手指衛生手技の確立を目指している。

6. 名古屋市における医療機関・診療所のアンチバイオグラムに関する研究

名古屋市内で感染対策向上加算1を取得している医療機関と、ファルコバイオシステムズが保有する名古屋市内の診療所等から得られた微生物検査データを用い、菌種分布および薬剤感受性を比較解析する研究を進めている。大規模病院群と、地域の第一線医療を担う診療所レベルのデータを解析・比較し、プライマリーケアの現場で活用できるアンチバイオグラムの構築を通じて、より実臨床に即した最適な抗菌薬治療の確立を目指している。

7. 迅速薬剤感受性試験（RAST）を用いた血流感染症の治療最適化に関する研究

重症感染症である血流感染症に対し、迅速かつ適切な抗菌薬治療の実現を目的とした臨床微生物学的研究を行っている。陽性化した血液培養検体を直接用いた迅速薬剤感受性試験（RAST）を院内で構築・運用し、標準的検査法である微量液体希釈法と比較・検証することで、迅速な治療の最適化を目指している。今後は日本の菌血症治療の現場に即したシステム構築に向けて、多施設共同研究を計画している。

8. 新生児集中治療室におけるエンテロ/パレコウイルス感染症のサーベイランスとその病態解析

エンテロウイルス/ヒトパレコウイルス感染症は小児での症状は軽微か不顕性であることが多いが、新生児では重症化することもある。しかしこれらのウイルス種の同定は保険診療になく、臨床でのリアルタイムのフィードバックは難しい。流行期に新生児集中治療室に入院中の患者の便を用いてウイルスPCRアッセイを定期的に行うアクティブサーベイランスと、検出された種の同定のためのゲノタイピングを行い、さらに重症化に関わる因子を特定する。"      
        
        
        
        
        
        

BIBLIOGRAPHY

2025
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2024
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  3. Amano T, Nishikawa T, Oka K, Ota K, Shimizu T. How an Antimicrobial Stewardship Team Treated a Nocardia farcinica-Associated Brain Abscess: A Case Report. Cureus. 2024 Feb 21;16(2):e54605.
  4. Morita Y, Tanahashi K, Terashima-Murase C, Fukaura R, Oka K, Yagi T, Miyamoto Y, Ato M, Ishii N, Akiyama M. Mycobacterium marinum infection successfully treated with oral administration of minocycline and thermotherapy. Nagoya J Med Sci. 2024 Nov;86(4):699-702.
  5. Inagaki T, Asahi S, Ogawa K, Nakagawa T, Ohkura T, Osada Y, Nikai T, Yamada K, Yagi T, Uchiya K-i. Development of a rapid detection method for the macrolide resistance gene in Mycobacterium avium using the amplification refractory mutation system-loop-mediated isothermal amplification method. Microbiol Spectr. 2024 Apr 2;12(4):e0233923.
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2023
  1. Fukaura R, Terashima-Murase C, Ota M, Noda H, Oka K, Ishihara Y, Shibayama K, Akiyama M. Methicillin-resistant Staphylococcus aureus-induced staphylococcal scalded skin syndrome in a preterm infant, and subsequent toxigenic analysis. J Dermatol. 2023 Dec;50(12):e422-e423. Epub 2023 Aug 22.
  2. Kobayashi H, Takeuchi S, Torii Y, Ikenouchi T, Kawada JI, Oka K, Kato S, Ogawa M. Time course of skin rash, computed tomography findings, and viral load in a rheumatoid arthritis patient with severe varicella pneumonia. IDCases. 2023 Jul 29;33:e01866.
  3. Oka K, Sahara S, Kuramae H, Osada Y. Mycobacterium obuense bacteremia: A case report and literature review. Int J Mycobacteriol. 2023 Jul-Sep;12(3):357-359.
  4. Kinoshita T, Sahara S, Amano T, Ito M, Sakakibara T, Takimoto N, Osada Y, Oka K. First Case Report of Peritoneal Dialysis-associated Peritonitis Caused by Lysinibacillus sphaericus. Intern Med. 2023 Oct 1;62(19):2919-2922. Epub 2023 Feb 22.
  5. Morioka H, Kaida H, Nishio M, Suga K. Peritonsillar abscess caused by Mycoplasma hominis and Fusobacterium necrophorum following oral sex. Auris Nasus Larynx. 2024 Apr;51(2):320-322. Epub 2023 Dec 2.
  6. Onishi K, Morioka H, Imaizumi T, Tsuchimoto D, Nishio M, Komiyama T. Risk factors for cefmetazole-non-susceptible bacteremia in acute cholangitis. J Infect Chemother. 2024 May;30(5):423-428. Epub 2023 Nov 18.
  7. Arisawa Y, Sugawara K, Morioka H, Takada K. Syphilis Showing Multiple Pulmonary Nodules without Respiratory Symptoms. Intern Med. 2024 Mar 15;63(6):885-886. Epub 2023 Aug 9.
  8. Aoki Y, Tamura T, Uchida W, Morioka H, Yamamoto M, Yuhara S, Nishio N, Mutsuga M, Furune S, Suzuki S, Nishiwaki K. Hypopharyngeal Injury by Transesophageal Echocardiography During Cardiac Surgery. J Cardiothorac Vasc Anesth. 2023 Oct;37(10):2027-2031. Epub 2023 Jun 19.
  9. Nishio M, Morioka H, Takai S, Osada Y, Seki Y, Osugi T, Oba A, Miyaki Y. Bacteraemia and obstructive pyelonephritis caused by Bifidobacterium breve in an elderly woman: a case report and literature review. Access Microbiol. 2023 Oct 19;5(10):000574.v3.
  10. Takamure K, Iwatani Y, Amano H, Yagi T, Uchiyama T. Inactivation characteristics of a 280 nm Deep-UV irradiation dose on aerosolized SARS-CoV-2. Environ Int. 2023; 177:108022.
  11. Kagami K, Ishiguro N, Iwasaki S, Usami T, Fukumoto T, Hayasaka K, Oyamada R, Watanabe T, Nakakubo S, Niinuma Y, Hagino T, Abe Y, Fujimoto I, Maekawa H, Fujibayashi R, Fuke S, Asahi K, Ota S, Nagakura T, Okubo T, Asanuma H, Ito T, Okano S, Komatsu E, Sasaki K, Hashimoto K, Washiya K, Kato Y, Kusumi K, Asai Y, Saito Y, Sakai Y, Sakurada M, Sakimoto Y, Ichikawa Y, Kinebuchi T, Kondo D, Kanno S, Kobayashi M, Hirabayashi K, Saitou S, Saito K, Ebina Y, Koshizaki Y, Chiba M, Yasuda A, Sato T, Togashi A, Abe T, Fujita T, Umehara K, Amishima M, Murakami N, Yagi T, Fujimoto S, Tajima T, Sugawara M, Takekuma Y. Correlation between antibiotic use and antibiotic resistance: A multicenter study using the Japan Surveillance for Infection Prevention and Healthcare Epidemiology (J-SIPHE) system in Hokkaido, Japan. Am J Infect Control. 2023 Feb;51(2):163-171.
2022
  1. Hara Y, Iguchi M, Tetsuka N, Morioka H, Hirabayashi A, Suzuki M, Tomita Y, Oka K, Yagi T. ＜Editors' Choice＞ Multicenter survey for carbapenemase-producing Enterobacterales in central Japan. Nagoya J Med Sci. 2022; 84(3):630-639.
  2. Sano M, Shindo Y, Takahashi K, Okumura J, Sakakibara T, Murakami Y, Iguchi M, Yagi T, Matsui S, Hasegawa Y. Risk factors for antibiotic resistance in hospital-acquired and ventilator-associated pneumonia. J Infect Chemother. 2022; 28(6):745-752.
  3. Oka K, Matsumoto A, Tetsuka N, Morioka H, Iguchi M, Ishiguro N, Nagamori T, Takahashi S, Saito N, Tokuda K, Igari H, Fujikura Y, Kato H, Kanai S, Kusama F, Iwasaki H, Furuhashi K, Baba H, Nagao M, Nakanishi M, Kasahara K, Kakeya H, Chikumi H, Ohge H, Azuma M, Tauchi H, Shimono N, Hamada Y, Takajo I, Nakata H, Kawamura H, Fujita J, Yagi T. Clinical characteristics and treatment outcomes of carbapenem-resistant Enterobacterales infections in Japan. J Glob Antimicrob Resist. 2022: 247-252.
  4. Sarangi J, Matsuo N, Nonogaki R, Hayashi M, Kawamura K, Suzuki M, Jin W, Tamai K, Ogawa M, Wachino JI, Kimura K, Yagi T, Arakawa Y. Molecular Epidemiology of Enterobacter cloacae Complex Isolates with Reduced Carbapenem Susceptibility Recovered by Blood Culture. Jpn J Infect Dis. 2022; 75(1):41-48
  5. Nonogaki R, Iijima A, Kawamura K, Kayama S, Sugai M, Yagi T, Arakawa Y, Doi Y, Suzuki M. PCR-based ORF typing of Klebsiella pneumoniae for rapid identification of global clones and transmission events. J Appl Microbiol. 2022; 133(3):2050-2062.
  6. Kobayashi H, Shindo Y, Kobayashi D, Sakakibara T, Murakami Y, Yagi M, Matsuura A, Sato K, Matsui K, Emoto R, Yagi T, Saka H, Matsui S, Hasegawa Y; Central Japan Lung Study Group. Extended-spectrum antibiotics for community-acquired pneumonia with a low risk for drug-resistant pathogens. Int J Infect Dis. 2022; 124:124-132.
  7. Nakai M, Oka K, Watanabe G, Kamei K, Tsukada N, Mori R, Nagaya M, Ukai Y, Tetsuka N, Morioka H, Iguchi M, Yagi T. Epidemiology and molecular characterization of fecal carriage of third-generation cephalosporin-resistant Enterobacterales among elderly residents in Japan. Journal of Infection and Chemotherapy. 2022; 28(4):569-575.
  8. Oka K, Tetsuka N, Morioka H, Iguchi M, Kawamura K, Hayashi K, Yanagiya T, Morokuma Y, Watari T, Kiyosuke M, Yagi T. Genetic and epidemiological analysis of ESBL-producing Klebsiella pneumoniae in three Japanese university hospitals. J Infect Chemother. 2022; 28(9):1286-1294.
  9. Morioka H, Ohge H, Nagao M, Kato H, Kokado R, Yamada K, Yamada T, Shimono N, Nukui Y, Yoshihara S, Sakamaki I, Nosaka K, Kubo Y, Kawamura H, Fujikura Y, Kitaura T, Sunakawa M, Yagi T. Appropriateness of surgical antimicrobial prophylaxis in Japanese university hospitals. J Hosp Infect. 2022; S0195-6701(22):00218-3.
  10. Murakami Y, Shindo Y, Sano M, Okumura J, Kobayashi H, Sakakibara T, Iguchi M, Takahashi K, Yagi T, Matsui S, Hasegawa Y. Effects of lymphocyte and neutrophil counts and their time courses on mortality in patients with postoperative pneumonia. Sci Rep. 2022 ;12(1):14564.
  11. Kobayashi Y, Shibata S, Yagi T. Molecular epidemiology and antimicrobial susceptibility profiles of Campylobacter jejuni isolated from bloodstream infections and enteritis in Japan. Diagnostic Microbiology and Infectious Disease. 2022; 103(2):115681.
  12. Morioka H, Oka K, Yamada Y, Nakane Y, Komiya H, Murase C, Iguchi M, Yagi T. Lysinibacillus fusiformis bacteremia: Case report and literature review. Journal of Infection and Chemotherapy 2022; 28(2):315-318.
  13. Sakakibara T, Shindo Y, Kobayashi D, Sano M, Okumura J, Murakami Y, Takahashi K, Matsui S, Yagi T, Saka H, Hasegawa Y. A prediction rule for severe adverse events in all inpatients with community-acquired pneumonia: a multicenter observational study. BMC Pulm Med. 2022; 22(1):34.
  14. Tetsuka N, Muramatsu H, Iguchi M, Oka K, Morioka H, Takahashi Y, Yagi T. Difficulties in diagnosing Malassezia furfur bloodstream infection and possibility of spontaneous resolution in a patient undergoing chemotherapy for neuroblastoma: A case report. J Infect Chemother. 2022; 28(7):987-990.
  15. Kagami K, Ishiguro N, Iwasaki S, Usami T, Fukumoto T, Hayasaka K, Oyamada R, Watanabe T, Nakakubo S, Niinuma Y, Hagino T, Abe Y, Fujimoto I, Maekawa H, Fujibayashi R, Fuke S, Asahi K, Ota S, Nagakura T, Okubo T, Asanuma H, Ito T, Okano S, Komatsu E, Sasaki K, Hashimoto K, Washiya K, Kato Y, Kusumi K, Asai Y, Saito Y, Sakai Y, Sakurada M, Sakimoto Y, Ichikawa Y, Kinebuchi T, Kondo D, Kanno S, Kobayashi M, Hirabayashi K, Saitou S, Saito K, Ebina Y, Koshizaki Y, Chiba M, Yasuda A, Sato T, Togashi A, Abe T, Fujita T, Umehara K, Amishima M, Murakami N, Yagi T, Fujimoto S, Tajima T, Sugawara M, Takekuma Y. Correlation between antibiotic use and antibiotic resistance: A multicenter study using the Japan Surveillance for Infection Prevention. Am J Infect Control. 2022; S0196-6553(22):00467-9.
  16. Akazawa N, Itoh N, Morioka H, Ogata T, Ishibana Y, Murakami H, Narita Y. Cholangitis with Sphingobacterium multivorum and Acinetobacter junii bacteremia in a patient with gastric cancer: A case report. J Infect Chemother. 2022 Oct;28(10):1419-1423. Epub 2022 Jun 16.
  17. Tsuchimoto D, Morioka H, Imaizumi T, Miyagawa S, Yamamoto M, Onishi K, Kuwabara Y, Takada K, Watamoto K. Current Status of Outpatient Oral Antimicrobial Prescription and the Influence of Antimicrobial Stewardship for Inpatients: A Repeated Cross-Sectional Study at a Japanese Community Hospital. Biol Pharm Bull. 2022;45(9):1340-1346.
  18. Kinoshita T, Sahara S, Mihara Y, Asai Y, Sato H, Sakakibara T, Takimoto N, Oka K. A case of acute focal bacterial nephritis caused by methicillin-resistant Staphylococcus saprophyticus in a 13-year-old adolescent girl treated with daptomycin. IDCases. 2022 Aug 6;29:e01594.
2021
  1. Sando Y, Morioka H, Sugawara K, Arisawa Y, Fukano H, Hoshino Y. A case of facial skin ulcer caused by Mycolicibacterium mageritense after tennis ball bruising. Int J Infect Dis. 2022 Jan;114:55-57. Epub 2021 Oct 27.
  2. Ryuge A, Saito S, Morioka H, Hachiya A, Kato N, Ishimoto T, Kosugi T, Maruyama S. Acquired Fanconi Syndrome in a Patient with Nontyphoidal Salmonella bacteremia. Intern Med. 2021 Mar 1;60(5):761-764. Epub 2020 Sep 30.
  3. Koshi E, Saito S, Okazaki M, Toyama Y, Ishimoto T, Kosugi T, Hiraiwa H, Jingushi N, Yamamoto T, Ozaki M, Goto Y, Numaguchi A, Miyagawa Y, Kato I, Tetsuka N, Yagi T, Maruyama S. Efficacy of favipiravir for an end stage renal disease patient on maintenance hemodialysis infected with novel coronavirus disease 2019. CEN Case Rep. 2021; 10(1):126-131.
  4. Morioka H, Iguchi M, Tetsuka N, Kinoshita F, Tomita Y, Kato D, Hirabayashi A, Matsumoto A, Oka K, Kato H, Inagaki T, Kato Y, Kitagawa K, Ichikawa K, Kouyama Y, Kawamura N, Toyotome Y, Adachi N, Ito Y, Yagi T. Five-year point prevalence survey of healthcare-associated infections and antimicrobial use in a Japanese university hospital. Infect Prev Pract. 2021; 3(3):100151
  5. Iwatsuki J, Kondo T, Takahashi N, Takami H, Nishigori H, Bustos-Villalobos I, Aleksic B, Kasuya H, Ban N, Yagi T, Skokauskas N. Problem-Based Learning in Child and Adolescent Psychiatry: A Perspective from Japan. Advances in Medical Education and Practice. 2021; 12: 1329-1335.
  6. Ebisui A, Inose R, Kusama Y, Koizumi R, Kawabe A, Ishii S, Goto R, Ishikane M, Yagi T, Ohmagari N, Muraki Y. Trends in Antipseudomonal Agent Use Based on the 2006 to 2015 Sales Data in Japan. Biological and Pharmaceutical Bulletin. 2021; 44(6):816-821.
  7. Oka K, Morioka H, Eguchi M, Sato Y, Tetsuka N, Iguchi M, Kanematsu T, Fukano H, Hoshino Y, Kiyoi H, Yagi T. Bursitis, Bacteremia, and Disseminated Infection of Mycobacteroides (Mycobacterium) abscessus subsp. Massiliense. Internal Medicine. 2021; 60(18):3041-3045.
2020
  1. Ishii S, Muraki Y, Kusama Y, Yagi T, Goto R, Ebisui A, Kawabe A, Inose R, Ohmagari N. The Trend for Antibiotic Use for Clostridioides (Clostridium) difficile Infection in Japan. Biol Pharm Bull. 2020; 43(4):693-696.
  2. Muraki Y, Kusama Y, Tanabe M, Hayakawa K, Gu Y, Ishikane M, Yamasaki D, Yagi T, Ohmagari N. Impact of antimicrobial stewardship fee on prescribing for Japanese pediatric patients with upper respiratory infections. BMC Health Serv Res. 2020; 20(1):399.
  3. Goto R, Inose R, Kusama Y, Kawabe A, Ishii S, Ebisui A, Ishikane M, Yagi T, Ohmagari N, Muraki Y. Trends of the Use of Anti-methicillin-Resistant Staphylococcus aureus Agents in Japan Based on Sales Data from 2006 to 2015. Biol Pharm Bull. 2020; 43(12):1906-1910.
  4. Ota A, Morita S, Matsuoka A, Shimaoka T, Maeda O, Mirsuma A, Yagi T, Asahara T, Ando Y. Detection of bacteria in blood circulation in patients receiving cancer chemotherapy. Int J Clin Oncol. 2020; 25(1):210-215.
  5. Sato Y, Iguchi M, Kato Y, Morioka H, Hirabayashi A, Tetsuka N, Tomita Y, Kato D, Yamada K, Kimura H, and Yagi T. Number of concomitant drugs with thrombocytopenic adverse effects and the extent inflammatory response resolution are risk factors for thrombocytopenia in patients treated with linezolid for more than 14 days. Nagoya J Med Sci. 2020; 82(3):407-414.
2019
  1. Tsutsui A, Yahara K, Clark A, Fujimoto K, Kawakami S, Chikumi H Iguchi M, Yagi T, Baker M A, O'Brien T, Stelling J. Automated detection of outbreaks of antimicrobial-resistant bacteria in Japan. The Journal of hospital infection. 2019; 102(2):226-233.
  2. Harada Y, Murata M, Matsumoto A, Kato D, Yagi T, Yaguchi T, Yoshikawa T, Takeichi T, Akiyama M, Yamaguchi Y, Koyama D, Terakura S, Nishida T, Kiyoi H. [Successful treatment of pre-engraftment disseminated fusariosis with high-dose liposomal]. Rinsho Ketsueki. 2019; 60(12):1641-1646.
  3. Tetsuka N, Hirabayashi A, Matsumoto A, Oka K, Hara Y, Morioka H, Iguchi M, Tomita Y, Suzuki M, Shibayama K, Yagi T. Molecular epidemiological analysis and risk factors for acquisition of carbapenemase-producing Enterobacter cloacae complex in a Japanese university hospital. Antimicrob Resist Infect Control. 2019; 8:126.
  4. Morioka H, Tokuda Y, Oshima H, Iguchi M, Tomita Y, Usui A, Yagi T. Fungal endocarditis after transcatheter aortic valve replacement (TAVR): Case report and review of literature. J Infect Chemother. 2019; 25(3):215-217.
2018
  1. Kato D, Morioka H, Tomita Y, Iguchi M, Hirabayashi A, Tetsuka N, Sadomoto T, Hyoudo M, Mochizuki M, Osada Y, Yamamoto M, Kato Y, Inagaki T, Ichikawa K, Yagi T. Active surveillance in response to the identification of a single carbapenemase-producing Escherichia coli at a Japanese university hospital. J Infect Chemother. 2018; 24(12):1013-1015.
  2. Morioka H, Nagao M, Yoshihara S, Ohge H, Kasahara K, Shigemoto N, Kajihara T, Mori M, Iguchi M, Tomita Y, Ichiyama S, Yagi T. The first multi-centre point-prevalence survey in four Japanese university hospitals. J Hosp Infect. 2018; S0195-6701(18):30143-9.
  3. Ohashi K, Matsuoka T, Shinoda Y, Fukami Y, Shindoh J, Yagi T, Yoshimura T, Sugiyama T. Evaluation of treatment outcomes of patients with MRSA bacteremia following antimicrobial stewardship programs with pharmacist intervention. Int J Clin Pract. 2018; 72(3):e13065.
  4. Horiba K, Kawada JI, Okuno Y, Tetsuka N, Suzuki T, Ando S, Kamiya Y, Torii Y, Yagi T, Takahashi Y, Ito Y. Comprehensive detection of pathogens in immunocompromised children with bloodstream infections by next-generation sequencing. Sci Rep. 2018; 8(1):3784.
  5. Sugawara G, Yokoyama Y, Ebata T, Igami T, Yamaguchi J, Mizuno T, Yagi T, Nagino M. Preoperative biliary colonization/infection caused by multidrug-resistant (MDR) pathogens in patients undergoing major hepatectomy with extrahepatic bile duct resection. Surgery. 2018; S0039-6060(18):30001-1.
  6. Sugawara G, Yokoyama Y, Ebata T, Mizuno T, Yagi T, Ando M, Nagino M. Duration of Antimicrobial Prophylaxis in Patients Undergoing Major Hepatectomy With Extrahepatic Bile Duct Resection: A Randomized Controlled Trial. Ann Surg. 2018; 267(1):142-148.
  7. Okumura J, Shindo Y, Takahashi K, Sano M, Sugino Y, Yagi T, Taniguchi H, Saka H, Matsui S, Hasegawa Y; Central Japan Lung Study Group. Mortality in patients with community-onset pneumonia at low risk of drug-resistant pathogens: Impact of β-lactam plus macrolide combination therapy. Respirology. 2018; 23(5):526-534.
  8. Yamasaki D, Tanabe M, Muraki Y, Kato G, Ohmagari N, Yagi T. The first report of Japanese antimicrobial use measured by national database based on health insurance claims data (2011-2013): comparison with sales data, and trend analysis stratified by antimicrobial category and age group. Infection. 2018; 46(2):207-214.
  9. Sugawara G, Yokoyama Y, Ebata T, Mizuno T, Yagi T, Ando M, Nagino M. Duration of Antimicrobial Prophylaxis in Patients Undergoing Major Hepatectomy With Extrahepatic Bile Duct Resection: A Randomized Controlled Trial. Ann Surg. 2018; 267(1):142-148.
2017
  1. Hirabayashi A, Kato D, Tomita Y, Iguchi M, Yamada K, Kouyama Y, Morioka H, Tetsuka N, Yagi T. Risk factors for and role of OprD protein in increasing minimal inhibitory concentrations of carbapenems in clinical isolates of Pseudomonas aeruginosa. J Med Microbiol. 2017; 66(11):1562-1572.
  2. Yamasaki D, Tanabe M, Muraki Y, Kato G, Ohmagari N, Yagi T. The first report of Japanese antimicrobial use measured by national database based on health insurance claims data (2011-2013): comparison with sales data, and trend analysis stratified by antimicrobial category and age group. Infection. 2017 Dec 22.
  3. Morioka H, Iguchi M, Kuzuya T, Mikamo H, Yagi T. Reccurent bacteremia and liver abscess caused by Clostridium difficile: A case report. Medicine (Baltimore). 2017; 96(35):e7969.
  4. Morioka H, Iguchi M, Oodate M, Yoneda M, Ushijima F, Hirabayashi A, Tetsuka N, Tomita Y, Kato D, Yagi T. Pneumococcal biliary tract infections-How rare are they? J Infect Chemother. 2017; 23(6):415-418.
  5. Kobayashi K, Imagama S, Kato D, Ando K, Hida T, Ito T, Tsushima M, Matsumoto A, Morozumi M, Tanaka S, Yagi T, Nishida Y, Ishiguro N. Collaboration with an infection control team for patients with infection after spine surgery. Am J Infect Control 2017; 45(7):767-770.
2016
  1. Adachi T, Ichikawa K, Inagaki T, Moriyama M, Nakagawa T, Ogawa K, Hasegawa Y, Yagi T. Molecular typing and genetic characterization of Mycobacterium avium subsp. hominissuis isolates from humans and swine in Japan. J Med Microbiol. 2016 Nov;65(11):1289-1295. Epub 2016 Sep 6.
  2. Muraki Y, Yagi T, Tsuji Y, Nishimura N, Tanabe M, Niwa T, Watanabe T, Fujimoto S, Takayama K, Murakami N, Okuda M. Japanese antimicrobial consumption surveillance: first report on oral and parenteral antimicrobial consumption in Japan (2009–2013). J Glob Antimicrob Resist. 2016 ;7:19-23
  3. Morioka H, Hirabayashi A, Iguchi M, Tomita Y, Kato D, Sato N, Hyodo M, Kawamura N, Sadomoto T, Ichikawa K, Inagaki T, Kato Y, Kouyama Y, Ito Y, Yagi T. The first point prevalence survey of health care-associated infection and antimicrobial use in a Japanese university hospital: A pilot study. Am J Infect Control 2016; 44(7):119-23.
  4. Morioka H, Yanagisawa N, Sasaki S, Sekiya N, Suganuma A, Imamura A, Ajisawa A, Kishida S. CD8 Encephalitis Caused by Persistently Detectable Drug-resistant HIV. Intern Med. 2016;55(10):1383-6. Epub 2016 May 15.
  5. Kato H, Yanagisawa N, Morioka H, Sasaki S, Sekiya N, Suganuma A, Imamura A, Ajisawa A. Laryngeal Kaposi's Sarcoma Complicated by the Immune Reconstitution Inflammatory Syndrome in an HIV-infected Patient. Intern Med. 2016;55(8):1001-5. Epub 2016 Apr 15.
2015
  1. Okachi S, Wakahara K, Kato D, Umeyama T, Yagi T, Hasegawa Y. Massive mediastinal cryptococcosis in a young immunocompetent patient. Respirol Case Rep 2015; 3(3):95-8.
  2. Ichikawa K, van Ingen J, Koh WJ, Wagner D, Salfinger M, Inagaki T, Uchiya K, Nakagawa T, Ogawa K, Yamada K, Yagi T. Genetic diversity of clinical Mycobacterium avium subsp. hominissuis and Mycobacterium intracellulare isolates causing pulmonary diseases recovered from different geographical regions. Infect Genet Evol 2015; 36:250-255.
  3. Shindo Y, Ito R, Kobayashi D, Ando M, Ichikawa M, Goto Y, Fukui Y, Iwaki M, Okumura J, Yamaguchi I, Yagi T, Tanikawa Y, Sugino Y, Shindoh J, Ogasawara T, Nomura F, Saka H, Yamamoto M, Taniguchi H, Suzuki R, Saito H, Kawamura T, Hasegawa Y; Central Japan Lung Study Group. Risk factors for 30-day mortality in patients with pneumonia who receive appropriate initial antibiotics: an observational cohort study. Lancet Infect Dis. 2015; 15(9):1055-1065.
  4. Uchiya K, Takahashi H, Nakagawa T, Yagi T, Moriyama M, Inagaki T, Ichikawa K, Nikai T, Ogawa K. Characterization lf a Novel Plasmid, pMAH135, from Mycobacterium avium Subsp. hominissuis. PLoS One 2015; 10(2):e0117797.
  5. Asai K, Yamada K, Yagi T, Baba H, Kawamura I, Ohta M. Effect of incubation atmosphere on the production and composition of staphylococcal biofilms. J Infect Chemother 2015; 21(1): 55-61.
  6. Ito R, Shindo Y, Kobayashi D, Ando M, Jin W, Wachino JI, Yamada K, Kimura K, Yagi T, Hasegawa Y, Arakawa Y. Molecular Epidemiological Characteristics of Klebsiella pneumonia Associated with Bacteremia among Patients with Pneumonia. J Clin Microbiol 2015; 53(3): 879-886.
2014
  1. Nakamura G, Wachino JI, Sato N, Kimura K, Yamada K, Jin W, Shibayama K, Yagi T, Kawamura K, Arakawa Y. Practical agar-based disk potentiation test for detection of fosfomycin-nonsusceptible Escherichia coli clinical isolates producing glutathione S-transferases. J Clin Microbiology 2014; 52(9):3175-3179.
2013
  1. Shindo Y, Ito R, Kobayashi D, Ando M, Ichikawa M, Shiraki A, Goto Y, Fukui Y, Iwaki M, Okamura J, Yamaguchi I, Yagi T, Tanikawa Y, Sugino Y, Shindou J, Ogasawara T, Nomura F, Saka H, Yamamoto M, Taniguchi H, Suzuki R, Saito H, Kawamura T, Hasagawa Y. Risk factors for drug-resistant pathogens in community-acquired and healthcare-associated pneumonia. Am J Respir Crit Care Med 2013;188(8):985-995.
  2. Yamaguchi M, Terao Y, Mori-Yamaguchi, Domon H, Sakaue Y, Yagi T, Nishino K, Yamaguchi A, Nizet V, Kawabata S. Streptococcus pneumoniae Invades Erythrocytes and Utilizes Them to Evade Human Innate Immunity. PLOS ONE. 2013; 8(10):e77282.
  3. Uchiya K, Takahashi H, Yagi T, Moriyama M, Inagaki T, Ichikawa K, Nakagawa T, Nikai T, Ogawa K. Comparative Genome Analysis of Mycobacterium avium Revealed Genetic Diversity in Strains that Cause Pulmonary and Disseminated Disease. PLOS ONE. 2013; 8(8):e71831
  4. Sugiura K, Sugiura N, Yagi T, Iguchi M, Ohno H, Miyazaki Y and Akiyama M. Cryptococcal cellulitis in a patient with bullous pemphigoid. Acta Derm Venereol. 2013; 93(2):187-188.
  5. Matsumura Y, Nagao M, Iguchi M, Yagi T, Komori T, Fujita N, Yamamoto M, Matsushima A, Takakura S, Ichiyama S. Molecular and clinical characterization of plasmid-mediated AmpC β-lactamase-producing Escherichia coli bacteraemia: a comparison with extended-spectrum β-lactamase-producing and non-resistant E. coli bacteraemia. Clin Microbiol Infect. 2013; 19(2):161-168.

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