研究報告：2018年
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1.
Tohnai
G, Nakamura R, Sone J, Nakatochi M, Yokoi D, Katsuno M, Watanabe H, Ito M, Li Y, Izumi Y, Morita M,
Taniguchi A, Kano O, Oda M, Kuwabara S, Abe K, Aiba I, Okamoto K, Mizoguchi K,
Hasegawa K, Aoki M, Hattori N, Onodera O, Naruse H, Mitsui J, Takahashi Y, Goto
J, Ishiura H, Morishita S, Yoshimura J, Doi K, Tsuji S, Nakashima K, Kaji R, Atsuta N, Sobue G; Japanese Consortium for
Amyotrophic Lateral Sclerosis Research (JaCALS): Frequency and characteristics
of the TBK1 gene variants in Japanese patients with sporadic amyotrophic lateral
sclerosis. Neurobiol
Aging. 64:
158.e15–158.e19, 2018
2. Yoneyama N, Watanabe H, Kawabata K, Bagarinao E, Hara
K, Tsuboi T, Tanaka Y, Ohdake R, Imai K, Masuda M, Hattori T,
Ito M, Atsuta N, Nakamura T, Hirayama M, Maesawa S, Katsuno
M, Sobue G: Severe hyposmia and aberrant functional connectivity in
cognitively normal Parkinson’s disease. PLoS One. 13: e0190072, 2018
3. Ninomiya H, Ohgami N, Oshino R, Kato M, Ohgami K, Li X, Shen D,
Iida M, Yajima I, Angelidis CE, Adachi H, Katsuno M, Sobue G, Kato M: Increased
expression level of Hsp70 in the inner ears of mice by exposure to low frequency
noise. Hear Res. 363: 49–54, 2018
4. Koike H, Nishi R, Ikeda
S, Kawagashira Y, Iijima M, Atsuta N, Nakamura T,
Hirayama M, Ogata H, Yamasaki R, Kira JI, Katsuno M, Sobue G: Restoration
of a Conduction Block after the Long-term Treatment of CIDP with Anti-neurofascin
155 Antibodies: Follow-up of a Case over 23 Years. Intern Med. 57:
2061–2066, 2018
5. Tanikawa C, Ueda K, Suzuki A, Iida A, Nakamura R, Atsuta
N, Tohnai G, Sobue G, Saichi N, Momozawa Y, Kamatani Y, Kubo M,
Yamamoto K, Nakamura Y, Matsuda K: Citrullination of RGG Motifs in FET Proteins
by PAD4 Regulates Protein Aggregation and ALS Susceptibility. Cell Rep.
22: 1473–1483, 2018
6. Sekijima Y, Yazaki M, Ueda M, Koike H, Yamada M,
Ando Y: First nationwide survey on systemic wild-type ATTR amyloidosis in
Japan. Amyloid. 25: 8–10, 2018
7.
Hijikata
Y, Katsuno M, Suzuki K, Hashizume A, Araki A,Yamada S, Inagaki T, Ito D, Hirakawa
A, Kinoshita F, Gosho M, Sobue G: Treatment
with Creatine Monohydrate in Spinal and Bulbar Muscular Atrophy: Protocol for a
Randomized, Double-Blind, Placebo-Controlled Trial. JMIR Res Protoc. 7: e69, 2018
8.
Hijikata
Y, Hashizume A,Yamada S, Inagaki T, Ito D, Hirakawa A, Suzuki K, Atsuta N,Tsuboi
T, Hattori M, Hori A, Banno H, Sobue G, Katsuno M: Biomarker-based analysis of
preclinical progression in spinal and bulbar muscular atrophy. Neurology. 90: e1501–e1509, 2018
9.
Kawabata
K, Watanabe H, Hara K, Bagarinao E, Yoneyama N, Ogura A, Imai K, Masuda M,
Yokoi T, Ohdake R, Tanaka Y,Tsuboi T, Nakamura
T, Hirayama M, Ito M, Atsuta N, Maesawa S, Naganawa S, Katsuno M, Sobue G: Distinct manifestation of
cognitive deficits associate with different resting-state network disruptions
in non-demented patients with Parkinson’s disease. J Neurol. 265: 688–700, 2018
10.
Koike
H, Katsuno M, Sobue G: Deciphering mechanism and spectrum of chronic inflammatory demyelinating
polyneuropathy by morphology. Clin Exp
Neuroimmunol. 9: 35–46,
2018
11.
Ikumi
K, Tsuboi T, Atsuta N, Takeuchi K, Koike H, Katsuno M:
Long-standing overt ventriculomegaly
without aqueductal stenosis: A case report. Neurol Clin Neurosci. 6: 42–44, 2018
12.
Tsuboi
T, Watanabe H, Funasaka K, Takebayashi M, Miyata K and
Katsuno M:
Peritonitis after percutaneous
endoscopic gastrojejunostomy for levodopa-carbidopa intestinal gel treatment
despite concomitant use of gastropexy. Neurol
Clin Neurosci. 6: 64–66, 2018
13. Bagarinao E, Watanabe H, Maesawa S, et al.: An unbiased
data-driven age-related structural brain parcellation for the identification of
intrinsic brain volume changes over the adult lifespan. Neuroimage. 169:
134–144, 2018
14. Sakamoto Y, Okamoto S, Maesawa S, Bagarinao E, Araki Y, Izumi T,
Watanabe H, Sobue G, Wakabayashi T: Default Mode Network Changes in
Moyamoya Disease Before and After Bypass Surgery: Preliminary Report. World
Neurosurg. 112: e652–e661, 2018
15.
Koike
H, Nishi R, Ikeda S, Kawagashira Y, Iijima M, Katsuno M, Sobue G: Ultrastructural mechanisms of
macrophage-induced demyelination in CIDP. Neurology. 91: 1051–1060, 2018
16.
Masuda
M, Watanabe H, Tanaka Y, Ohdake R, Ogura A, Yokoi T, Imai K, Kawabata K, Riku
Y, Hara K, Nakamura R, Atsuta N, Katsuno M, Sobue G: Age-related impairment in Addenbrooke’s cognitive examination
revised scores in patients with amyotrophic lateral sclerosis. Amyotroph
Lateral Scler Frontotemporal Degener. 19: 578–584, 2018
17.
Yokoi
T, Watanabe H, Yamaguchi H, Bagarinao E, Masuda M, Imai K, Ogura A, Ohdake R,
Kawabata K, Hara
K, Riku Y, Ishigaki
S, Katsuno M
, Miyao S, Kato K, Naganawa S, HaradaR, Okamura N, Yanai K, Yoshida M,
Sobue G: Involvement of the Precuneus/Posterior Cingulate Cortex Is Significant
for the Development of Alzheimer’s Disease: A PET (THK5351, PiB) and Resting
fMRI Study. Front Aging Neurosci. 10: 304,
2018
18.
Hashizume
A, Katsuno M:
IGF-1 for spinal and bulbar muscular
atrophy: hope and challenges. Lancet
Neurol. 17: 1026–1027, 2018
19.
Koike
H, Nishi R, Ikeda S, Kawagashira Y, Iijima M, Sakurai T, Shimohata T, Katsuno M, Sobue G: The morphology of amyloid
fibrils and their impact on tissue damage in hereditary transthyretin amyloidosis: An ultrastructural study. J
Neurol Sci. 394: 99–106,
2018
20.
Katsuno
M, Sahashi K, Iguchi Y, Hashizume A: Preclinical progression of neurodegenerative diseases. Nagoya J Med Sci. 80: 289–298, 2018
21.
Yamada
S, Hashizume A, Hijikata Y, Inagaki T, Ito D, Kinoshita F, Nakatochi M, Kobayashi Y, Hirakawa A, Nakamura T, Katsuno
M: Study protocol for
the MEXiletine hydrochloride administration trial: a placebocontrolled,
randomised, double-blind, multicentre, crossover study of its efficacy and safety
in spinal and bulbar muscular atrophy (MEXPRESS). BMJ Open. 8: e023041, 2018
22.
Watanabe
H, Riku Y, Hara K, Kawabata K, Nakamura T, Ito M, Hirayama M, Yoshida M,
Katsuno M, Sobue G: Clinical and Imaging Features
of Multiple System Atrophy: Challenges for an Early and Clinically Definitive
Diagnosis. J Mov Disord. 11: 107–120, 2018
23.
Koike
H, Nakamura T, Nishi R, Ikeda S, Kawagashira Y, Iijima M, Katsuno M, Sobue G: Widespread Cardiac and Vasomotor
Autonomic Dysfunction in Non-Val30MetHereditary Transthyretin Amyloidosis. Intern
Med. 57: 3365–3370, 2018
24.
Hara
K, Watanabe H, Bagarinao E, Kawabata K, Yoneyama N, Ohdake R, Imai K, Masuda M, Yokoi T, Ogura A, Tsuboi T, Ito M, Atsuta N, Niwa H, Taoka T, Maesawa S, Naganawa S, Katsuno M, Sobue G: Corpus callosal involvement
is correlated with cognitive impairment in multiple system atrophy. J Neurol. 265: 2079–2087, 2018
25. Xu Y, Halievski K, Katsuno M, Adachi H, Sobue G,
Breedlove SM, Jordan CL: Pre-clinical symptoms of SBMA may not be
androgen-dependent: implications from two SBMA mouse models. Hum Mol Genet.
27: 2425–2442, 2018
26. Koike H, Yasuda T, Nishi R,
Ikeda S, Kawagashira Y, Iijima M, Sobue G, Katsuno M:
Systemic angiopathy and axonopathy in hereditary transthyretin amyloidosis with
Ala97Gly (p. Ala117Gly) mutation: a post-mortem analysis. Amyloid. 25:
141–142, 2018
27. Ando T, Goto Y, Mano K, Nomura
F, Kurashige M, Ito M, Mimuro M, Iwasaki Y, Katsuno M, Yoshida M:
Paraneoplastic autoimmune encephalitis associated with pleomorphic lung
carcinoma: An autopsy case report. Neuropathology. 2018 May 20
28. Hijikata Y, Hashizume A, Yamada
S, Inagaki T, Ito D, Hirakawa A, Suzuki K, Atsuta N, Tsuboi
T, Hattori M, Hori A, Banno H, Sobue G, Katsuno M: Biomarker-based
analysis of preclinical progression in spinal and bulbar muscular atrophy. Neurology.
90: e1501–e1509, 2018
29. Ninomiya H, Ohgami N, Oshino R, Kato M, Ohgami K, Li X, Shen D,
Iida M, Yajima I, Angelidis CE, Adachi H, Katsuno M, Sobue G, Kato M: Increased
expression level of Hsp70 in the inner ears of mice by exposure to low frequency
noise. Hear Res. 363: 49–54, 2018
30. Koike H, Nishi R, Ikeda
S, Kawagashira Y, Iijima M, Atsuta N, Nakamura T,
Hirayama M, Ogata H, Yamasaki R, Kira JI, Katsuno M, Sobue G: Restoration
of a Conduction Block after the Long-term Treatment of CIDP with Anti-neurofascin
155 Antibodies: Follow-up of a Case over 23 Years. Intern Med. 57: 2061–2066,
2018
31.
Tohnai
G, Nakamura R, Sone J, Nakatochi M, Yokoi D, Katsuno M, Watanabe H, Ito M, Li Y, Izumi Y, Morita M, Taniguchi A, Kano O,
Oda M, Kuwabara S, Abe K, Aiba I, Okamoto K, Mizoguchi K, Hasegawa K, Aoki M,
Hattori N, Onodera O, Naruse H, Mitsui J, Takahashi Y, Goto J, Ishiura H,
Morishita S, Yoshimura J, Doi K, Tsuji S, Nakashima K, Kaji R, Atsuta N, Sobue G ; Japanese Consortium for
Amyotrophic Lateral Sclerosis Research (JaCALS): Frequency and characteristics
of the TBK1 gene variants in Japanese patients with sporadic amyotrophic
lateral sclerosis. Neurobiol Aging. 64:
158.e15–158.e19, 2018
32.
Kawabata
K, Watanabe H, Hara K, Bagarinao E, Yoneyama N, Ogura A, Imai K, Masuda
M, Yokoi T, Ohdake R, Tanaka Y, Tsuboi T, Nakamura T, Hirayama M, Ito M, Atsuta N, Maesawa S, Naganawa S, Katsuno M, Sobue G: Distinct manifestation of cognitive deficits associate with
different resting-state network disruptions in non-demented patients with
Parkinson’s disease. J Neurol. 265: 688–700, 2018
33.
Endo
K, Ishigaki S, Masamizu Y, Fujioka Y, Watakabe A, Yamamori T, Hatanaka N, Nambu
A, Okado H, Katsuno M, Watanabe H, Matsuzaki M, Sobue G: Silencing of FUS in the
common marmoset (Callithrix jacchus) brain via stereotaxic injection of an
adeno-associated virus encoding shRNA. Neurosci Res. 130: 56–64, 2018
34. Suzuki A, Ito M, Hamaguchi T, Mori H, Takeda Y, Baba R, Watanabe
T, Kurokawa K, Asakawa S, Hirayama M, Ohno K: Quantification of hydrogen
production by intestinal bacteria that are specifically dysregulated in
Parkinson’s disease. PLoS One. 13: e0208313, 2018
35. Abe K, Hirayama M, Ohno K, Shimamura T: A latent
allocation model for the analysis of microbial composition and disease. BMC
Bioinformatics. 19: 519, 2018
36. Misawa S, Kuwabara S, Sato Y, Yamaguchi N, Nagashima K, Katayama
K, Sekiguchi Y, Iwai Y, Amino H, Suichi T, Yokota T, Nishida Y, Kanouchi T,
Kohara N, Kawamoto M, Ishii J, Kuwahara M, Suzuki H, Hirata K, Kokubun N,
Masuda R, Kaneko J, Yabe I, Sasaki H, Kaida KI, Takazaki H, Suzuki N, Suzuki S,
Nodera H, Matsui N, Tsuji S, Koike H, Yamasaki R, Kusunoki S; Japanese Eculizumab
Trial for GBS (JET-GBS) Study Group: Safety and efficacy of eculizumab in
Guillain-Barré syndrome: a multicentre, doubleblind, randomised phase 2 trial. Lancet
Neurol. 17: 519–529, 2018
37. Watanabe E, Fujita T, Shimono M, Koike H, Yasumoto S,
Hirose S: Recurrent autonomic and sensory neuropathy in a patient with
anti-ganglionic acetylcholine receptor antibodies. eNeurologicalSci. 12:
36–38, 2018
38. Sekijima Y, Yazaki M, Ueda M, Koike H, Yamada M, Ando Y: First
nationwide survey on systemic wild-type ATTR amyloidosis in Japan. Amyloid.
25: 8–10, 2018
39. Fujimori K, Ishikawa M, Otomo A, Atsuta N, Nakamura R,
Akiyama T, Hadano S, Aoki M, Saya H, Sobue G, Okano H: Modeling sporadic ALS in
iPSC-derived motor neurons identifies a potential therapeutic agen.t Nat Med.
24: 1579–1589, 2018
40. Sobue G, Ishigaki S, Watanabe H: Pathogenesis of
Frontotemporal Lobar Degeneration: Insights From Loss of Function Theory and
Early Involvement of the Caudate Nucleus. Front Neurosci. 12: 473, 2018
41. Ishigaki S, Sobue G: Importance of
Functional Loss of FUS in FTLD/ALS. Front Mol Biosci. 5: 44, 2018
42. Oki R, Izumi Y, Nodera H, Sato Y, Nokihara H, Kanai K, Sonoo M,
Urushitani M, Nishinaka K, Atsuta N, Kohara N, Shimizu T, Kikuchi H, Oda
M, Ikeda K, Nagai M, Komai K, Kojima Y, Kuzume D, Isose S, Shimohama S, Abe K,
Ito H, Noda K, Ishihara T, Morita M, Shimohata T, Teramukai S, Kagimura T, Noma
K, Yanagawa H, Kuwabara S, Kaji R; JETALS: The Japanese Early-Stage Trial of
High-Dose Methylcobalamin for Amyotrophic Lateral Sclerosis (JETALS): Protocol
for a Randomized Controlled Trial. JMIR Res Protoc. 7: e12046, 2018
Sahashi K, Katsuno M: Pathogenesis of Polyglutamine Diseases eLS.
John Wiley & Sons, Ltd: Chichester. Sinha R, Kim YJ, Nomakuchi T, Sahashi
K, Hua Y, Rigo F, Bennett CF, Krainer AR: Antisense oligonucleotides
correct the familial dysautonomia splicing defect in IKBKAP transgenic mice. Nucleic
Acids Res. 46: 4833–4844, 2018
43. Kuwabara S, Misawa S, Mori M, Iwai Y, Ochi K, Suzuki H, Nodera
H, Tamaoka A, Iijima M, Toda T, Yoshikawa H, Kanda T, Sakamoto K,
Kusunoki S, Sobue G, Kaji R; Glovenin-I MMN Study Group: Intravenous
immunoglobulin for maintenance treatment of multifocal motor neuropathy: A
multi-center, open-label, 52-week phase 3 trial. J Peripher Nerv Syst.
23: 115–119, 2018
44. Iijima M: Animal models of chronic
inflammatory demyelinating polyneuropathy. Clin Exp Neuroimmunol. 9:
101–109, 2018