研究報告：2016年
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1. Orimo S, Yogo M, Nakamura T, Suzuki M, Watanabe H: (123)I-meta-iodobenzylguanidine
(MIBG) cardiac scintigraphy in α-synucleinopathies. Ageing Res Rev. Feb,
2016
2. Maeda O, Yokota K, Atsuta N, Katsuno M, Akiyama M, Ando Y: Nivolumab
for the treatment of malignant melanoma in a patient with pre-existing myasthenia
gravis. Nagoya J Med Sci. 78: 119–122, 2016
3. Nakamura R, Sone J, Atsuta N, Tohnai G, Watanabe H, Yokoi D,
Nakatochi M, Watanabe H, Ito M, Senda J, Katsuno M, Tanaka F, Li Y, Izumi Y,
Morita M, Taniguchi A, Kano O, Oda M, Kuwabara S, Abe K, Aiba I, Okamoto K,
Mizoguchi K, Hasegawa K, Aoki M, Hattori N, Tsuji S, Nakashima K, Kaji R, Sobue
G ; Japanese Consortium for Amyotrophic Lateral Sclerosis Research (JaCALS): Next-generation
sequencing of 28 ALS-related genes in a Japanese ALS cohort. Neurobiol Aging.
39: 219.e1–8, 2016
4. Senda J, Ito K, Kotake T, Kanamori M, Kishimoto H, Kadono I, Suzuki Y,
Katsuno M, Nishida Y, Ishiguro N, Sobue G: Association of Leukoaraiosis
With Convalescent Rehabilitation Outcome in Patients With Ischemic Stroke.
Stroke. 47: 160–166, 2016
5. Araki K, Ito M, Atsuta N, Katsuno M, Sobue G: Serial magnetic
resonance angiography in a patient with angioinvasive aspergillosis. Neurology
and Clinical Neuroscience. 4: 73–75, 2016
6. Yoritaka A, Abe T, Ohtsuka C, Maeda T, Hirayama M, Watanabe H,
Saiki H, Oyama G, Fukae J, Shimo Y, Hatano T, Kawajiri S, Okuma Y, Machida Y,
Miwa H, Suzuki C, Kazama A, Tomiyama M, Kihara T, Hirasawa M, Shimura H,
Hattori N: A randomized double-blind multi-center trial of hydrogen water for
Parkinson’s disease: protocol and baseline characteristics. BMC Neurol.
16: 66, 2016
7. Kimura T, Tucker A, Sugimura T, Seki T, Fukuda S, Takeuchi S,
Miyata S, Fujita T, Hashizume A, Izumi N, Kawasaki K, Katsuno M, Hashimoto M,
Sako K: Ultra-Early Combination Antiplatelet Therapy with Cilostazol for the
Prevention of Branch Atheromatous Disease: A Multicenter Prospective Study. Cerebrovasc
Dis Extra. 6: 84–95, 2016
8. Noda T, Iijima M, Noda S, Maeshima S, Nakanishi H, Kimura S,
Koike H, Ishigaki S, Iguchi Y, Katsuno M, Sobue G: Gene Expression Profile of
Inflammatory Myopathy with Malignancy is Similar to that of Dermatomyositis
rather than Polymyositis. Intern Med. 55: 2571–2580, 2016
9. Ando T, Goto Y, Mano K, Ueda A, Ando Y, Mizuta I, Mizuno T: CADASIL Presenting
as Acute Bilateral Multiple Subcortical Infarcts without a Characteristic
Temporal Pole or Any External Capsule Lesions. Intern Med. 55: 2873–2876, 2016
10. Okada A, Nakamura T, Suzuki J, Suzuki M, Hirayama M, Katsuno M,
Sobue G: Impaired Pain Processing Correlates with Cognitive Impairment in
Parkinson’s Disease. Intern Med. 55: 3113–3118, 2016
11. Hirayama M, Minato T, Maeda T, Nakamura T, Katsuno M: Efficacy
of a novel drug zonisamide in the modulation of oxidative stress in Parkinson’s
disease. Neurology and Clinical Neuroscience. 5: 49–54, 2016
12. Hirayama M, Tsunoda M, Yamamoto M, Tsuda T, Ohno K: Serum
tyrosine-to-phenylalanine ratio is low in Parkinson’s disease. Journal of
Parkinson’s disease. 2-6: 423–431, 2016
13. Pourshafie N, Lee PR, Chen KL, Harmison GG, Bott LC, Katsuno M,
Sobue G, Burnett BG, Fischbeck KH, Rinaldi C: MiR-298 Counteracts Mutant
Androgen Receptor Toxicity in Spinal and Bulbar Muscular Atrophy. Mol Ther.
24: 937–945, 2016
14. Xu Y, Halievski K, Henley C, Atchison WD, Katsuno M, Adachi H,
Sobue G, Breedlove SM, Jordan CL: Defects in Neuromuscular Transmission May
Underlie Motor Dysfunction in Spinal and Bulbar Muscular Atrophy. J Neurosci.
36: 5094–5106, 2016
15. Bott LC, Badders NM, Chen KL, Harmison GG, Bautista E, Shih CC,
Katsuno M, Sobue G, Taylor JP, Dantuma NP, Fischbeck KH, Rinaldi C: A small-molecule
Nrf1 and Nrf2 activator mitigates polyglutamine toxicity in spinal and bulbar
muscular atrophy. Hum Mol Genet. 25: 1979–1989, 2016
16. Hirunagi T, Tsujikawa K, Hasegawa Y, Mano K, Katsuno M: Elderly-onset
familial myasthenia gravis in two siblings. Neuromuscul Disord. 26:
347–349, 2016
17. Yokoi D, Atsuta N, Watanabe H, Nakamura R, Hirakawa A, Ito M,
Watanabe H, Katsuno M, Izumi Y, Morita M, Taniguchi A, Oda M, Abe K, Mizoguchi
K, Kano O, Kuwabara S, Kaji R, Sobue G; JaCALS: Age of onset differentially influences
the progression of regional dysfunction in sporadic amyotrophic lateral
sclerosis. J Neurol. 263: 1129–1136, 2016
18. Ikumi K, Ando T, Katano H, Katsuno M, Sakai Y, Yoshida M, Saida
T, Kimura H, Sobue G: HSV-2-related hemophagocytic lymphohistiocytosis in a
fingolimod-treated patient with MS. Neurol Neuroimmunol Neuroinflamm. 3:
e247, 2016
19. Ando T, Goto Y, Mano K: Upper back restlessness: Two case
reports. J Neurol Sci. 365: 137–138, 2016
20. Kubo S, Hamada S, Maeda T, Uchiyama T, Hashimoto M, Nomoto N, Kano
O, Takahashi T, Terashi H, Takahashi T, Hatano T, Hasegawa T, Baba Y, Sengoku
R, Watanabe H, Kadowaki T, Inoue M, Kaneko S, Shimura H, Nagayama H: A Japanese
multicenter survey characterizing pain in Parkinson’s disease. J Neurol Sci.
365: 162–166, 2016
21. Ohyama K, Koike H, Hashimoto R, Takahashi M, Kawagashira Y,
Iijima M, Katsuno M, Sobue G: Intraepidermal nerve fibre density in POEMS
(Crow-Fukase) syndrome and the correlation with sural nerve pathology. J
Neurol Sci. 365: 207–211, 2016
22. Nakashima H, Ohkawara B, Ishigaki S, Fukudome T, Ito K, Tsushima
M, Konishi H, Okuno T, Yoshimura T, Ito M, Masuda A, Sobue G, Kiyama H,
Ishiguro N, Ohno K: R-spondin 2 promotes acetylcholine receptor clustering at
the neuromuscular junction via Lgr5. Sci Rep. 6: 28512, 2016
23. Hijikata Y, Katsuno M, Suzuki K, Hashizume A, Araki A, Yamada S,
Inagaki T, Iida M, Noda S, Nakanishi H, Banno H, Mano T, Hirakawa A, Adachi H,
Watanabe H, Yamamoto M, Sobue G: Impaired muscle uptake of creatine in spinal
and bulbar muscular atrophy. Ann Clin Transl Neurol. 3: 537–546, 2016
24. Riku Y, Watanabe H, Yoshida M, Mimuro M, Iwasaki Y, Masuda M,
Ishigaki S, Katsuno M, Sobue G: Marked Involvement of the Striatal Efferent
System in TAR DNA-Binding Protein 43kDa-Related Frontotemporal Lobar Degeneration
and Amyotrophic Lateral Sclerosis. J Neuropathol Exp Neurol. 75:
801–811, 2016
25. Ding Y, Adachi H, Katsuno M, Sahashi K, Kondo N, Iida M, Tohnai
G, Nakatsuji H, Sobue G: BIIB021, a synthetic Hsp90 inhibitor, induces mutant
ataxin-1 degradation through the activation of heat shock factor 1. Neuroscience.
327: 20–31, 2016
Iwatsuki K, Yoshida A, Shinohara T, Nakano T, Uemura J, Goto S, Hirayama
M, Hoshiyama M, Hirata H: Recovery function of somatosensory evoked brain
response in patients with carpal tunnel syndrome: A magnetoencephalographic
study. Clin Neurophysiol.
127: 2733–2738, 2016
26. Watanabe H, Atsuta N, Hirakawa A, Nakamura R, Nakatochi M,
Ishigaki S, Iida A, Ikegawa S, Kubo M, Yokoi D, Watanabe H, Ito M, Katsuno M,
Izumi Y, Morita M, Kanai K, Taniguchi A, Aiba I, Abe K, Mizoguchi K, Oda M,
Kano O, Okamoto K, Kuwabara S, Hasegawa K, Imai T, Kawata A, Aoki M, Tsuji S,
Nakashima K, Kaji R, Sobue G: A rapid functional decline type of amyotrophic
lateral sclerosis is linked to low expression of TTN. J Neurol Neurosurg
Psychiatry. 87: 851–858, 2016
27. Yoshida T, Ueki Y, Suzuki T, Kawagashira Y, Koike H, Kusumoto S,
Ida S, Oguri T, Omura M, Sobue, Matsukawa N: Guillain-Barré syndrome after
allogeneic bone marrow transplantation: Case report and literature review. eNeurologicalSci.
4: 52–55, 2016
28. Watanabe Y, Beeldman E, Raaphorst J, Izumi Y, Yoshino H, Masuda
M, Atsuta N, Ito S, Adachi T, Adachi Y, Yokota O, Oda M, Hanashima R, Ogino M,
Ichikawa H, Hasegawa K, Kimura H, Shimizu T, Aiba I, Yabe H, Kanba M, Kusumi K,
Aoki T, Hiroe Y, Watanabe H, Nishiyama K, Nomoto M, Sobue G, Nakashima K;
ALS-FTD-Q-J Research Group: Japanese version of the ALS-FTD-Questionnaire
(ALS-FTD-Q-J). J Neurol Sci. 367: 51–55, 2016
29. Tsujikawa K, Hara K, Muro Y, Nakanishi H, Niwa Y, Koike M, Noda
S, Riku Y, Sahashi K, Atsuta N, Ito M, Shimoyama Y, Akiyama M, Katsuno M: HMGCR
antibody-associated myopathy as a paraneoplastic manifestation of esophageal carcinoma.
Neurology. 87: 841–843, 2016
30. Fujita K, Motoki K, Tagawa K, Chen X, Hama H, Nakajima K, Homma
H, Tamura T, Watanabe H, Katsuno M, Matsumi C, Kajikawa M, Saito T, Saido T,
Sobue G, Miyawaki A, Okazawa H: HMGB1, a pathogenic molecule that induces
neurite degeneration via TLR4-MARCKS, is a potential therapeutic target for
Alzheimer’s disease. Sci Rep. 6: 31895, 2016
31. Nakamura T, Suzuki M, Okada A, Suzuki J, Hasegawa S, Koike H, Hirayama
M, Katsuno M, Sobue G: Association of leptin with orthostatic blood pressure
changes in Parkinson’s disease. Mov Disord. 31: 1417–1421, 2016
32. Orimo S, Yogo M, Nakamura T, Suzuki M, Watanabe H: (123)I-meta-iodobenzylguanidine
(MIBG) cardiac scintigraphy in α-synucleinopathies. Ageing Res Rev. 30:
122–133, 2016
33. Tsujikawa K, Senda J, Yasui K, Hasegawa Y, Hoshiyama M, Katsuno
M, Sobue G: Distinctive distribution of brain volume reductions in MELAS and
mitochondrial DNA A3243G mutation carriers: A voxel-based morphometric study. Mitochondrion.
30: 229–235, 2016
34. Misawa S, Sato Y, Katayama K, Nagashima K, Aoyagi R, Sekiguchi
Y, Sobue G, Koike H, Yabe I, Sasaki H, Watanabe O, Takashima H, Nishizawa M,
Kawachi I, Kusunoki S, Mitsui Y, Kikuchi S, Nakashima I, Ikeda S, Kohara N,
Kanda T, Kira J, Hanaoka H, Kuwabara S; Japanese POEMS Syndrome for Thalidomide
(J-POST) Trial Study Group: Safety and efficacy of thalidomide in patients with
POEMS syndrome: a multicentre, randomised, double-blind, placebo-controlled
trial. Lancet Neurol. 15: 1129–1137, 2016
35. Kino Y, Washizu C, Kurosawa M, Yamada M, Doi H, Takumi T, Adachi
H, Katsuno M, Sobue G, Hicks GG, Hattori N, Shimogori T, Nukina N: FUS/TLS acts
as an aggregation-dependent modifier of polyglutamine disease model mice. Sci
Rep. 6: 35236, 2016
36. Tanaka Y, Tsuboi T, Watanabe H, Kajita Y, Nakatsubo D, Fujimoto
Y, Ohdake R, Ito M, Atsuta N, Yamamoto M, Wakabayashi T, Katsuno M, Sobue G: Articulation
Features of Parkinson’s Disease Patients with Subthalamic Nucleus Deep Brain
Stimulation. J Parkinsons Dis. 6: 811–819, 2016
37. Masuda M, Senda J, Watanabe H, Epifanio B, Tanaka Y, Imai K,
Riku Y, Li Y, Nakamura R, Ito M, Ishigaki S, Atsuta N, Koike H, Katsuno M,
Hattori N, Naganawa S, Sobue G: Involvement of the caudate nucleus head and its
networks in sporadic amyotrophic lateral sclerosis-frontotemporal dementia
continuum. Amyotroph Lateral Scler Frontotemporal Degener. 17: 571–579,
2016
38. Erratum in: Amyotroph Lateral Scler Frontotemporal Degener.
17, 2016 Ando T, Araki A, Terao S, Saka Y: Bilateral internal capsule lesions
in uremic encephalopathy. Neurology and Clinical Neuroscience. 4: 243,
2016
39. Yamaguchi N, Misawa S, Sato Y, Nagashima K, Katayama K,
Sekiguchi Y, Iwai Y, Amino H, Suichi T, Yokota T, Nishida Y, Kohara N, Hirata
K, Nishiyama K, Yabe I, Kaida KI, Suzuki N, Nodera H, Tsuji S, Koike H, Kira
JI, Hanaoka H, Kusunoki S, Kuwabara S; JET-GBS Group: A Prospective, Multicenter,
Randomized Phase II Study to Evaluate the Efficacy and Safety of Eculizumab in
Patients with Guillain-Barré Syndrome (GBS): Protocol of Japanese Eculizumab
Trial for GBS (JET-GBS). JMIR Res Protoc. 5: e210, 2016
40. Koike H, Ikeda S, Takahashi M, Kawagashira Y, Iijima M, Misumi
Y, Ando Y, Ikeda SI, Katsuno M, Sobue G: Schwann cell and endothelial cell
damage in transthyretin familial amyloid polyneuropathy. Neurology. 87:
2220–2229, 2016
41. Yokoi S, Yasui K, Hasegawa Y, Niwa K, Noguchi Y, Tsuzuki T,
Mimuro M, Sone J, Watanabe H, Katsuno M, Yoshida M, Sobue G: Pathological
background of subcortical hyperintensities on diffusion-weighted images in a
case of neuronal intranuclear inclusion disease. Clin Neuropathol. 35:
375–380, 2016
42. Senda J, Watanabe H, Endo K, Yasui K, Hawsegawa Y, Yoneyama N,
Tsuboi T, Hara K, Ito M, Atsuta N, Epifanio B Jr, Katsuno M, Naganawa S, Sobue
G: Active brain changes after initiating fingolimod therapy in multiple
sclerosis patients using individual voxel-based analyses for diffusion tensor
imaging. Nagoya J Med Sci. 78: 455–463, 2016
43. Sone J, Mori K, Inagaki T, Katsumata R, Takagi S, Yokoi S, Araki
K, Kato T, Nakamura T, Koike H, Takashima H, Hashiguchi A, Kohno Y, Kurashige
T, Kuriyama M, Takiyama Y, Tsuchiya M, Kitagawa N, Kawamoto M, Yoshimura H,
Suto Y, Nakayasu H, Uehara N, Sugiyama H, Takahashi M, Kokubun N, Konno T,
Katsuno M, Tanaka F, Iwasaki Y, Yoshida M, Sobue G: Clinicopathological
features of adult-onset neuronal intranuclear inclusion disease. Brain.
139: 3170–3186, 2016
44. Iguchi Y, Eid L, Parent M, Soucy G, Bareil C, Riku Y, Kawai K,
Takagi S, Yoshida M, Katsuno M, Sobue G, Julien JP: Exosome secretion is a key
pathway for clearance of pathological TDP-43. Brain. 139: 3187–3201,
2016
45. Kadoya M, Kaida K, Koike H, Takazaki H, Ogata H, Moriguchi K,
Shimizu J, Nagata E, Takizawa S, Chiba A, Yamasaki R, Kira JI, Sobue G, Ikewaki
K: IgG4 anti-neurofascin155 antibodies in chronic inflammatory demyelinating
polyradiculoneuropathy: Clinical significance and diagnostic utility of a
conventional assay. J Neuroimmunol. 301: 16–22, 2016
46. Yamada S, Hashizume A, Hijikata Y, Inagaki T, Suzuki K, Kondo N,
Kawai K, Noda S, Nakanishi H, Banno H, Hirakawa A, Koike H, Halievski K, Jordan
CL, Katsuno M, Sobue G: Decreased Peak Expiratory Flow Associated with Muscle
Fiber-Type Switching in Spinal and Bulbar Muscular Atrophy. PLoS One.
11: e0168846, 2016