研究報告：2015年

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1.      Tanaka Y, Tsuboi T, Watanabe H, Kajita Y, Fujimoto Y, Ohdake R, Yoneyama N, Masuda M, Hara K, Senda J, Ito M, Atsuta N, Horiguchi S, Yamamoto M, Wakabayashi T, Sobue G: Voice features of Parkinson’s disease patients with subthalamic nucleus deep brain stimulation. J Neurol. 262: 1173-1181, 2015

2.      Maeshima S, Koike H, Noda S, Noda T, Nakanishi H, Iijima M, Ito M, Kimura S, Sobue G: Clinicopathological features of sarcoidosis manifesting as generalized chronic myopathy. J Neurol. 262; 1035-1045, 2015

3.      Koike H, Akiyama K, Saito T, Sobue G; Research Group for IVIg for EGPA/CSS in Japan: Intravenous immunoglobulin for chronic residual peripheral neuropathy in eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome): a multicenter, double-blind trial. J Neurol. 262: 752–759, 2015

4.      Oki K, Halievski K, Vicente L, Xu Y, Zeolla D, Poort J, Katsuno M, Adachi H, Sobue G, Wiseman RW, Breedlove SM, Jordan CL: Contractile dysfunction in muscle may underlie androgen-dependent motor dysfunction in spinal bulbar muscular atrophy. J Appl Physiol (1985). 118: 941–952, 2015

5.      Koike H,Takahashi M, Ohyama K, Hashimoto R, Kawagashira Y, Iijima M, Katsuno M, Doi H, Tanaka F, Sobue G: Clinicopathologic features of folate-deficiency neuropathy. Neurology. 84: 1026–1033, 2015

6.      Maesawa S, Bagarinao E, Fujii M, Futamura M, Motomura K, Watanabe H, Mori D, Sobue G, Wakabayashi T: Evaluation of resting state networks in patients with gliomas: connectivity changes in the unaffected side and its relation to cognitive function. PLoS One. 10: e0118072, 2015

7.      Katayama K, Misawa S, Sato Y, Sobue G, Yabe I, Watanabe O, Nishizawa M, Kusunoki S, Kikuchi S, Nakashima I, Ikeda S, Kohara N, Kanda T, Kira J, Hanaoka H, Kuwabara S; J-POST Trial study investigators: Japanese POEMS syndrome with Thalidomide (J-POST) Trial: study protocol for a phase II/III multicentre, randomised, double-blind, placebo-controlled trial. BMJ Open. 5: e007330, 2015

8.      Kawagashira Y, Koike H, Ohyama K, Hashimoto R, Iijima M, Adachi H, Katsuno M, Chapman M, Lunn M, Sobue G: Axonal loss influences the response to rituximab treatment in neuropathy associated with IgM monoclonal gammopathy with anti-myelin-associated glycoprotein antibody. J Neurol Sci. 348: 67–73, 2015

9.      Okada A, Koike H, Nakamura T, Motomura M, Sobue G: Efficacy of intravenous immunoglobulin for treatment of Lambert-Eaton myasthenic syndrome without anti-presynaptic P/Q-type voltage-gated calcium channel antibodies: a case report. Neuromuscul Disord. 25: 70–72, 2015

10.    Iida M, Katsuno M, Nakatsuji H, Adachi H, Kondo N, Miyazaki Y, Tohnai G, Ikenaka K, Watanabe H, Yamamoto M, Kishida K, Sobue G :Pioglitazone suppresses neuronal and muscular degeneration caused by polyglutamineexpanded androgen receptors. Hum Mol Genet. 24: 314–329, 2015

11.    Hua Y, Liu YH, Sahashi K, Rigo F, Bennett CF, Krainer AR: Motor neuron cell-nonautonomous rescue of spinal muscular atrophy phenotypes in mild and severe transgenic mouse models. Genes & Development. 29: 288–289, 2015

12.    Hashizume A, Katsuno M, Suzuki K, Banno H, Suga N, Mano T, Araki A, Hijikata Y, Grunseich C, Kokkinis A, Hirakawa A, Watanabe H, Yamamoto M, Fischbeck KH, Sobue G: A functional scale for spinal and bulbar muscular atrophy: Cross-sectional and longitudinal study. Neumuscul Disord. 25: 554-562. 2015

13.    Mano T, Katsuno M, Banno H, Suzuki K, Suga N, Hashizume A, Araki A, Hijikata Y, Tanaka S, Takatsu J, Watanabe H, Yamamoto M, Sobue G: Head Lift Exercise Improves Swallowing Dysfunction in Spinal and Bulbar Muscular Atrophy. Eur Neurol. 74: 251–258, 2015

14.    Hashimoto R, Koike H, Takahashi M, Ohyama K, Kawagashira Y, Iijima M, Sobue G: Uncompacted Myelin Lamellae and Nodal Ion Channel Disruption in POEMS Syndrome. J Neuropathol Exp Neurol. 74: 1127–1136, 2015

15.    Ding Y, Adachi H, Katsuno M, Huang Z, Jiang YM, Kondo N, Iida M, Tohnai G, Nakatsuji H, Funakoshi H, Nakamura T, Sobue G: Overexpression of hepatocyte growth factor in SBMA model mice has an additive effect on combination therapy with castration. Biochem Biophys Res Commun. 468: 677–683, 2015

16.    Hikiji T, Norisada J, Hirata Y, Okuda K, Nagasawa H, Ishigaki S, Sobue G, Kiuchi K, Oh-hashi K: A highly sensitive assay of IRE1 activity using the small luciferase NanoLuc: Evaluation of ALS-related genetic and pathological factors. Biochem Biophys Res Commun. 463, 881–887, 2015

17.    Koike H, Ohyama K, Kawagashira Y, Iijima M, Sobue G: Clinicopathological features of folate-deficiency neuropathy. Author response. Neurology. 85, 1091, 2015

18.    Ohyama K, Koike H, Takahashi M, Kawagashira Y, Iijima M, Watanabe H, Sobue G: Immunoglobulin G4-related pathologic features in inflammatory neuropathies. Neurology. 85: 1400–1407, 2015

19.    Hashizume A, Katsuno M, Suzuki K, Banno H, Suga N, Mano T, Araki A, Hijikata Y, Grunseich C, Kokkinis A, Hirakawa A, Watanabe H, Yamamoto M, Fischbeck KH, Sobue G: A functional scale for spinal and bulbar muscular atrophy: Cross-sectional and longitudinal study. Neuromuscul Disord. 25: 554–562, 2015

20.    Araki K, Nakanishi H, Nakamura T, Atsuta N, Yamada S, Hijikata Y, Hashizume A, Suzuki K, Katsuno M, Sobue G: Myotonia-like symptoms in a patient with spinal and bulbar muscular atrophy. Neuromuscul Disord. 25: 913–915, 2015

21.    Tsuboi T, Watanabe H, Tanaka Y, Ohdake R, Yoneyama N, Hara K, Ito M, Hirayama M, Yamamoto M, Fujimoto Y, Kajita Y, Wakabayashi T, Sobue G: Characteristic laryngoscopic findings in Parkinson’s disease patients after subthalamic nucleus deep brain stimulation and its correlation with voice disorder. J Neural Transm (Vienna). 122: 1663–1672, 2015

22.    Foyez T, Takeda-Uchimura Y, Ishigaki S, Narentuya, Zhang Z, Sobue G, Kadomatsu K, Uchimura K: Microglial keratan sulfate epitope elicits in central nervous tissues of transgenic model mice and patients with amyotrophic lateral sclerosis. Am J Pathol. 185: 3053–3065, 2015

23.    Sahashi K, Katsuno M, Hung G, Adachi H, Kondo N, Nakatsuji H, Tohnai G, Iida M, Bennett CF, Sobue G: Silencing neuronal mutant androgen receptor in a mouse model of spinal and bulbar muscular atrophy. Hum Mol Genet. 24: 5985–5994, 2015

24.    Nagahara Y, Shimazawa M, Tanaka H, Ono Y, Noda Y, Ohuchi K, Tsuruma K, Katsuno M, Sobue G, Hara H: Glycoprotein nonmetastatic melanoma protein B ameliorates skeletal muscle lesions in a SOD1G93A mouse model of amyotrophic lateral sclerosis. J Neurosci Res. 93: 1552–1566, 2015

25.    Suzuki J, Nakamura T, Hirayama M, Mizutani Y, Okada A, Ito M, Watanabe H, Sobue G: Impaired peripheral vasoconstrictor response to orthostatic stress in patients with multiple system atrophy. Parkinsonism Relat Disord. 21: 917–922, 2015

26.    Uruha A, Hayashi YK, Oya Y, Mori-Yoshimura M, Kanai M, Murata M, Kawamura M, Ogata K, Matsumura T, Suzuki S, Takahashi Y, Kondo T, Kawarabayashi T, Ishii Y, Kokubun N, Yokoi S, Yasuda R, Kira J, Mitsuhashi S, Noguchi S, Nonaka I, Nishino I: Necklace cytoplasmic bodies in hereditary myopathy with early respiratory failure. J Neurol Neurosurg Psychiatry. 86: 483–489, 2015

27.    Watanabe H, Sobue G: Filling in the missing puzzle piece between cardiac MIBG scintigraphy findings and Parkinson’s disease pathology. J Neurol Neurosurg Psychiatry. 86: 937, 2015

28.    Tsujikawa K, Hasegawa Y, Yokoi S, Yasui K, Nanbu I, Yanagi T, Takahashi A: Chronological changes of 123I-MIBG myocardial scintigraphy and clinical features of Parkinson’s disease. J Neurol Neurosurg Psychiatry. 86: 945–951, 2015

29.    Masuda A, Takeda J, Okuno T, Okamoto T, Ohkawara B, Ito M, Ishigaki S, Sobue G, Ohno K: Position-specific binding of FUS to nascent RNA regulates mRNA length. Genes Dev. 29: 1045–1057, 2015

30.    Udagawa T, Fujioka Y, Tanaka M, Honda D, Yokoi S, Riku Y, Ibi D, Nagai T, Yamada K, Watanabe H, Katsuno M, Inada T, Ohno K, Sokabe M, Okado H, Ishigaki S, Sobue G: FUS regulates AMPA receptor function and FTLD/ALS-associated behavior via GluA1 mRNA stabilization. Nat Commun. 6: 7098, 2015

31.    Sasaki S, Iguchi Y, Katsuno M, Sobue G: Alterations in the blood-spinal cord barrier in TDP-43 conditional knockout mice. Neurosci Lett. 598: 1–5, 2015

32.    Halievski K, Henley CL, Domino L, Poort JE, Fu M, Katsuno M, Adachi H, Sobue G, Breedlove SM, Jordan CL: Androgen-dependent loss of muscle BDNF mRNA in two mouse models of SBMA. Exp Neurol. 269: 224–232, 2015

33.    Endo F, Komine O, Fujimori-Tonou N, Katsuno M, Jin S, Watanabe S, Sobue G, Dezawa M, Wyss-Coray T, Yamanaka K: Astrocyte-derived TGF-β1 accelerates disease progression in ALS mice by interfering with the neuroprotective functions of microglia and T cells. Cell Rep. 11: 592–604, 2015

34.    Maeshima S, Koike H, Noda S, Noda T, Nakanishi H, Iijima M, Ito M, Kimura S, Sobue G: Clinicopathological features of sarcoidosis manifesting as generalized chronic myopathy. J Neurol. 262: 1035–1045, 2015

35.    Tanaka Y, Tsuboi T, Watanabe H, Kajita Y, Fujimoto Y, Ohdake R, Yoneyama N, Masuda M, Hara K, Senda J, Ito M, Atsuta N, Horiguchi S, Yamamoto M, Wakabayashi T, Sobue G: Voice features of Parkinson’s disease patients with subthalamic nucleus deep brain stimulation. J Neurol. 262: 1173–1181, 2015

36.    Oki K, Halievski K, Vicente L, Xu Y, Zeolla D, Poort J, Katsuno M, Adachi H, Sobue G, Wiseman RW, Breedlove SM, Jordan CL: Contractile dysfunction in muscle may underlie androgen-dependent motor dysfunction in spinal bulbar muscular atrophy. J Appl Physiol (1985). 118: 941–952, 2015

37.    Oh-Hashi K, Sone A, Hikiji T, Hirata Y, Vitiello M, Fedele M, Ishigaki S, Sobue G, Kiuchi K: Transcriptional and post-transcriptional regulation of transmembrane protein 132A. Mol Cell Biochem. 405: 291–299, 2015

38.    Shimojo D, Onodera K, Doi-Torii Y, Ishihara Y, Hattori C, Miwa Y, Tanaka S, Okada R, Ohyama M, Shoji M, Nakanishi A, Doyu M, Okano H, Okada Y: Rapid, efficient, and simple motor neuron differentiation from human pluripotent stem cells. Mol Brain. 8: 79, 2015

39.    Uchida Y, Takada K, Tsugu Y, Ueda M, Yamashita T, Ando Y, Kobayashi S, Koike H, Watanabe T, Matsumoto T, Toyoda T, Yamada G, Matsukawa N: Two brothers homozygous for the TTR V30M both presenting with a phenotype dominated by central nervous complications. Amyloid. 22: 261–262, 2015

40.    Toyota T, Huang Z, Nohara S, Okada K, Kakeda S, Korogi Y, Nakayama T, Sone J, Sobue G, Adachi H: Neuronal intranuclear inclusion disease manifesting with new-onset epilepsy in the elderly. Neurology and Clinical Neuroscience. 3: 238–240, 2015