Introduction to Radiotracer Disposition
Kinetics: Analysis by Mathematical Modeling
SHUHEI YAMAMOTO
pg(s)1 - 7
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The most prevalent use of a radioactive tracer is to assess specific organ function for diagnostic
purpose. This analysis is performed by obtaining a time-activity curve of the tracer and then developing
an appropriate mathematical model for disposition kinetics of the tracer. This article provides an
introductory guide to several aspects of this method, which has been successfully applied in various
experimental and clinical studies.
Septic Shock with Hyperglycemia Induced
by Hypothalamic Dysfunction after Removal
of Large Parasagittal Meningioma
HIROJI KUCHIWAKI and MITSUO SUGIURA
pg(s) 9 - 15
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Septic shock (Klebsiella pneumoniae infection) accompanied with chronic hypokalemia and
postoperative hyperglycemia was induced by surgical and infectious stress in a 64-year-old female
patient with a large parasagittal meningioma that compressed the hypothalamic area. We concluded
that a dysfunction of the compressed hypothalamus had some relation to the grave prognosis after
surgical removal of the tumor.
Purified Protein Derivative (PPD)
Tuberculin as a Biological Response Modifier:
I. Suppression of Tumor Markers
by Intravenous Administration of PPD
MASAO IINUMA, KATSUYA KATO, HIIZU AOKI, KOICHI ANDO, IZUMI NAKASHIMA and SAIJI YOSHII
pg(s) 17 - 26
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Forty-two patients with neoplastic diseases received intravenous administration of PPD (PPD-V),
and tumor markers were monitored between January, 1986 and February, 1987. Tumor markers
such as CEA, AFP, SCC, CA125, IAP and polyamines decreased significantly following the PPD-V
therapy. In some cases, PPD-V therapy also reduced the progression of clinical manifestation of the
disease. We could not detect serum IL-2 or TNF activity. IL-2 production and sensitivity of
lymphocytes were also undetectable. Intravenous administration of PPD was concluded to be effective
as an adjuvant therapy against human neoplastic disease. A reduction of tumor markers was
observed in 19 of the 26 assessable patients (73%). We discussed the mechanism of suppression of
tumor markers by PPD-V therapy.
New Approach to the Aneurysm Originating
in the Ascending Aorta, Eroding
the Sternum and Extending to the Cervix
EIJI TAKEUCHI, MITSUYA MURASE, MINORU TANAKA,
TAKASHI WATANABE, AKIHIKO USUI and TOSHIO ABE
pg(s) 27 - 34
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When operating on a false aneurysm arising in the ascending aorta, protruding over the sternum,
and eroding the sternum, the problems are how to approach the aneurysm and how to preserve the
myocardium and the brain safely. In the present case, the operation was performed for the first
time, to the best of our knowledge, safely by flipping up the eroded upper half of the sternum with
separated clavicles and ribs, under a femoro-femoro (F-F) bypass and isolated brain perfusion.
Patterns of Regional Cerebral Blood Flow
in Patients with Occlusive or Stenotic
Lesions of Both the Internal Carotid
and Vertebrobasilar Arteries
HIROJI KUCHIWAKI, HITOSHI ISHIGURI, SOHSHUN TAKADA
and JUNKI ITOH
pg(s) 35 - 43
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For the study of cerebral hemodynamics in patients with multiple occlusive or stenotic lesions of
the internal carotid artery (lCA) and vertebral/basilar artery (VA/BA), six male patients (mean aged
62.5 years) were examined by regional cerebral blood flow(rCBF; Fg: intravenous bolus injection of
Xe 133). The highest rCBF(73.3 ± l6.l(SD)ml/100g/min) was observed in two patients with
stenosis of the VA and bilateral ICAs and the lowest rCBF(47.l ± 5.9), in patients with severe
stenosis of the BA including unilateral occlusion or stenosis of the VA and ICA. Intermediate rCBF
(56.1 ± 10.0) was found in patients with occlusion of the VA and occlusion or stenosis of the
bilateral ICAs. Among them lesions without VA-occlusion and BA-stenosis were important in keeping
rCBF high.
