研究室紹介LABORATORY

神経内科学

KEYWORDS

  • 神経変性疾患
  • 認知症
  • 筋萎縮性側索硬化症
  • 球脊髄性筋萎縮症
  • パーキンソン病
  • 多系統萎縮症
  • 脊髄小脳変性症
  • 末梢神経疾患
  • 筋疾患
  • アルツハイマー型認知症
  • 前頭側頭型認知症
  • 臨床試験・治験

HEAD

勝野 雅央

教授

研究者総覧

LAB MEMBER

構成員名 役職 研究者総覧
佐橋 健太郎 准教授 研究者総覧
井口 洋平 講師 研究者総覧
坪井 崇 病院助教 研究者総覧
鈴木 将史 病院助教 研究者総覧
横井 聡 准教授 研究者総覧
飯田 円 助教 研究者総覧
山田 晋一郎 病院講師 研究者総覧
深見 祐樹 特任助教 研究者総覧
伊藤 大輔 特任助教 研究者総覧
小倉 礼 助教 研究者総覧
辻河 高陽 特任准教授 研究者総覧
蛭薙 智紀 特任助教 研究者総覧

CONTACT

Email neurology◎med.nagoya-u.ac.jp（送信の際は◎を@に変更してください）
HP 神経内科学 独自ホームページ

OUTLINE

当教室は昭和59年4月11日に名古屋大学医学部附属病院診療科として認可されました。初代教授として髙橋昭先生が昭和60年3月1日付けで就任され、教室として正式に発足しました。平成3年4月21日には名古屋大学医学部神経内科学講座が設置されました。 名古屋大学医学部における神経内科学（神経病学）の診療・教育・研究の歴史は古く、そのはじまりは明治期、愛知医学校における川原汎先生まで遡り、我が国の神経内科学分野として、最も古い伝統を継承しています。第二次世界大戦後は第１内科学講座において神経研究室（第４研究室）として数多くの臨床研究業績を生み、日本の神経学を牽引する活躍を遂げてきました。 平成7年4月、祖父江元教授が就任し、神経変性疾患の分野で世界をリードし国内外から高い注目を受けてきました。 平成27年7月に、勝野雅央教授が就任し、これまでの伝統を大切にしつつ、更なる発展を遂げることができるよう努力しています。 令和８年現在、同窓は約470名にのぼり、中部地区を中心に全国レベルで神経内科学の臨床・研究に活躍しています。最新のエビデンスに基づく診療と、双方向性を取り入れた卒前・卒後教育を進めるとともに、研究面では基礎から臨床へと展開するトランスレーショナルリサーチ（TR）と、臨床データから病態解明・治療開発へと繋げるリバースTRを推進し、認知症やパーキンソン病をはじめとする脳神経疾患の超早期病態の解明と先制・予防治療の開発に取り組んでいます。

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また、神経変性疾患の領域を中心に、国際連携、産学連携および患者市民参画（PPI）に積極的に取り組んでいます。

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RESEARCH PROJECTS

以下の研究グループにてそれぞれのグループが独自の研究を展開しており、ご紹介いたします。

  • ALSグループ
  • 核酸創薬グループ
  • iPS細胞研究グループ
  • ゲノム解析グループ
  • 臨床試験グループ（運動ニューロン疾患臨床研究）
  • レビー小体病グループ
  • パーキンソン病・運動障害疾患グループ
  • 認知症・画像解析研究グループ
  • 末梢神経疾患グループ
  • 筋疾患グループ
  • 神経生理・自律神経研究グループ

1．ALSグループ

最も致死的な神経変性疾患である筋萎縮性側索硬化症(ALS)の病態解明を目指す

筋萎縮性側索硬化症 (ALS) は成人以降に発症し、全身性、進行性の筋萎縮・筋力低下をきたす予後不良の神経変性疾患です。ALSは大脳皮質運動野に存在する上位運動ニューロンと脳幹脳神経核や脊髄前角の下位運動ニューロンが選択的に細胞死に至ります。ALSの進行を十分に抑制する治療法は未だ開発されていませんが、近年の精力的な研究によりALS病態の理解には革新的な進歩がみられています。ALSの運動ニューロンやグリア細胞では核タンパク質であるTDP-43が核から消失し、細胞質で凝集体として蓄積することがわかっています。このTDP-43の凝集体毒性と機能喪失病態がALSの発症や進行の主要病態であると考えられており、当グループはTDP-43に焦点を当てて研究を行っています。既にIKKβというリン酸化酵素がTDP-43の細胞質凝集体を選択的に減少させること（Iguchi et al. J Cell Biol 2024）や、TDP-43の機能喪失が運動ニューロン変性に直接的に影響すること（Iguchi et al. Brain 2016）、その一因としてNEAT1という非翻訳長鎖RNAの低下（Kawakami et al. Brain Commun 2025）を報告しています。

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2．核酸創薬グループ

異分野融合による神経難病のスマート化研究

当グループでは遺伝性疾患である球脊髄性筋萎縮症（SBMA）と脊髄性筋萎縮症（SMA）の病態解明と核酸医薬開発の研究に取り組んでいます。SBMAについては単一細胞核RNA-seqやAIも活用し神経回路活動、転写・翻訳、細胞形態・内部構造などを解析し、種々の神経細胞の、時期特異的な病態の理解を深めています（Iida et al. JCI Insight 2025）。また工学、理学、創薬科学の応用、産学連携、国際連携により、ポリグルタミン病、パーキンソン病関連疾患、運動ニューロン疾患の実用化を見据えた核酸医薬開発を推進しています（Maeda et al. Mol Ther Nucleic Acids 2025; Hirunagi et al. J Cachexia Sarcopenia Muscle 2024）。
SMAについては企業、ARO、CROの協力による全国レジストリ研究を継続し、臨床データの解析、患者コメント・画像のAI解析、体液の高感度ELISAによる解析を行い、薬効評価バッテリーやバイオマーカーの開発と、適正治療に関するエビデンスの創出を目指しています。さらに環境医学研究所と協働し、ロングリードシークエンスによるバリアント、疾患修飾因子、RNA代謝を解析しており、神経難病の診断向上や治療法の社会実装に向け、基礎・臨床両研究が双方向性に結びついた成果の創出を目標としています。

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３．iPS細胞研究グループ

患者iPS細胞から樹立した運動神経を用いてALSの詳細な分子病態メカニズムに迫る

iPS細胞研究グループはiPS細胞を用いてALSの病態解明研究を行っています。特にALSの原因となるRNA結合タンパク質であるFUS, TDP-43に着目し、これらのRNA結合タンパク質が直接制御する、神経変性の原因となる異常RNAの探索に注力しています。先行研究では、FUSがシナプスタンパク質であるSYNGAP1のmRNAの安定化によりシナプス形態の制御を行っていることを発見し、ALS患者コホートのJaCALSにおいてFUSがSYNGAP1のmRNAに結合する部位に新規変異を見出しました（Yokoi et al. J Neurosci 2022）。
この変異を正常iPS細胞に遺伝子編集技術で組み込み、分化誘導した運動ニューロンのシナプス数が減少することを報告しました。現在は、RNA結合タンパク質に変異を有するALS患者由来iPS細胞を用いて、神経活動を経時的に解析可能なカルシウムライブイメージングなどの技術を駆使し、ALSの治療薬につながる詳細な分子病態を解明する研究を進めています。

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4．ゲノム解析グループ

最先端ゲノム解析と多角的アプローチで挑む、難病の病態解明と創薬

ゲノム解析グループは、神経難病や難治性筋疾患のゲノム病態の解明を目指し、名古屋大学環境医学研究所との緊密な連携のもと、大規模な全ゲノム解析を推進しています。特にタウ蛋白が異常凝集する進行性核上性麻痺（PSP）の研究では、従来の観察研究や家系解析にとどまらず、全国規模のゲノムコホートとの共同解析や疾患モデル動物の開発を経て、現在では企業との産学連携を基盤としたトランスレーショナル研究へと発展しています（Tsujikawa et al. Sci Adv 2022）。
さらに、学内外の複数の研究室・研究機関と協力し、最新のロングリード・シークエンサーを駆使したゲノム構造変異の網羅的解析や、スーパーコンピューターを用いた分子動力学シミュレーションによる病態の物理学的理解にも取り組んでいます。また、AI技術を応用した神経細胞形態の自動解析や、細胞モデルを活用した創薬アッセイの開発も積極的に進めています。臨床に携わる医師が、自ら高度なバイオインフォマティクスを習得することで、膨大なゲノムデータの解析に臨床的知見や独自の視点を正確に反映させることが可能となります。これにより、従来のシステムエンジニア主導の解析では見落とされがちな病態の核心に迫ることができ、研究成果をより直接的に臨床へと還元する道が開かれます。
こうした多角的な取り組みを通じて、基礎医学・臨床医学・情報科学を横断的に結びつけ、神経難病や難治性筋疾患に苦しむ患者さんに革新的な診断・治療法を届けることを最終目標としています。

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５．臨床試験グループ（運動ニューロン疾患臨床研究）

運動ニューロン疾患の治療薬シーズ探索と臨床応用への挑戦

当グループでは球脊髄性筋萎縮症（SBMA）や筋萎縮性側索硬化症（ALS）などを中心とした臨床研究、臨床試験（医師主導治験を含む）を進めています。
SBMAについては、リュープロレリン酢酸塩（名古屋大学神経内科学の研究成果をもとに2017年薬事承認）のトランスレーショナルリサーチ（TR）の経験をもとに、現在はメキシレチン塩酸塩の臨床開発に取り組んでいます。SBMA患者さんの多くは寒冷暴露によって運動麻痺や巧緻運動障害の悪化を呈します。この現象から着想を得て実施した研究結果をもとに、SBMAに対するメキシレチン塩酸塩の医師主導治験 (Med-SBMA trial)を実施しています。また、多くの神経変性疾患では症状が出現する前に分子レベルで病態が進行していることが指摘されていることから、当グループではSBMAの超早期病態やバイオマーカーについて研究しています（Torii et al. Neurology 2023）。
ALSについては、患者さんから得られるバイオサンプルの解析を中心に、ALSの進行に関連するバイオマーカーや発症前に変化するバイオマーカーの研究を実施しています。特にオミクス解析（トランスクリプトミクス、プロテオミクス、メタボロミクス、エクソソームmiRNAなど）を駆使して、対象物質の網羅的な測定を実施し、機械学習などを用いて解析しています。将来的には、これらのオミクス解析結果を統合して、患者さんの体内で何が起きているのかを明らかにすることを目標にしています。さらに、それらの病態を基礎研究において検証をする、リバースTR（rTR）をテーマに病態解明、治療薬開発研究を進めています。

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6．レビー小体病グループ

健診から前駆期をとらえ、予後予測と先制医療をめざすコホート研究

レビー小体グループでは、2017年より健診受診者を対象とした質問紙調査に基づくレビー小体病発症ハイリスク者コホート研究（NaT-PROBE研究）を進めています。これまでの解析から、50歳以上の健診受診者のうち約6%が複数の前駆症状（自律神経障害、レム睡眠行動異常症、嗅覚障害）を有するレビー小体病発症ハイリスク者であることを明らかにしました（Hattori et al. J Neurol 2020）。さらに、その約3分の1でDaT-SPECTまたはMIBG心筋シンチグラフィの集積低下を認め（Hattori et al. NPJ Parkinsons Dis 2023）、約半数で神経変性マーカーである血漿ニューロフィラメント軽鎖（NfL）の上昇を確認しています（Hiraga et al. NPJ Parkinsons Dis 2024）。加えて、発症前の軽微な運動症状を捉える新規質問紙を開発し（Tamakoshi et al. J Parkinsons Dis 2025）、多様な前駆期集団の抽出にも取り組んでいます。これらの一連の成果は、ハイリスク者において臨床症状が現れる以前から神経変性が進行していることを示す重要な知見であり、先制治療の対象集団を同定する基盤となります。私たちは、これらの知見をもとにレビー小体病前駆期の層別化・予後予測モデルの構築を進め、先制医療の実現に向けた学術的基盤を確立することを目指しています。

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7．パーキンソン病・運動障害疾患グループ

病態解析から先進治療まで、多領域で挑む運動障害疾患研究

パーキンソン病・運動障害疾患グループでは、パーキンソン病や振戦性疾患の診断・治療の向上を目指し、臨床と工学の両面から幅広い研究を行っています。進行期パーキンソン病では、脳深部刺激療法（DBS）、レボドパ経腸液療法、レボドパ持続皮下注療法などの近年進歩の著しいデバイス補助療法を対象に運動症状や非運動症状を含めた多面的な効果解析を行い、適応判断や治療効果の向上に役立つ知見を蓄積しています（Tsuboi et al. J Neural Transm 2025）。また、本態性振戦やジストニア性振戦については、集束超音波（FUS）やDBSなどによる個別化された外科的治療の提供と並行して、詳細な臨床観察、生理学的解析、画像解析を組み合わせた病態解析を進めています。さらに、パーキンソン病患者を対象としたTobii視線解析装置による視覚認知機能の病態解析や、発話課題・自然会話中の表情・音声データを用いた診断支援技術の開発にも取り組んでいます（Uematsu et al. Parkinsonism Relat Disord 2024）。脳神経外科や工学分野をはじめとした多領域の専門家との共同研究体制を活かし、臨床現場に直結する成果を創出するとともに、運動障害疾患の本質に多面的に迫ることを目指しています。

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8．認知症・画像解析研究

認知症の早期診断・治療反応と健常者の脳内神経基盤を探る機能的ネットワーク研究

認知症・画像解析研究グループは、機能的MRI（fMRI）を用いて、アルツハイマー型認知症およびプレクリニカル期認知症における脳機能ネットワークの変化を明らかにすることを目的とした研究を行っています。安静時fMRIを用いた大規模ネットワーク解析を通じて、臨床症状出現前の微細な神経基盤の異常を捉え、早期診断や病態理解に貢献することを目指しています。 また、今後は血漿バイオマーカーの測定やプロテオーム解析を組み合わせ、認知症の早期診断・進行予測・治療効果判定に役立つ新たな指標の探索にも取り組んでいく予定です。画像とバイオマーカーを統合することで、将来的には個別化医療や新規治療法の開発につながることが期待されます。
さらに、産学連携を通じて他学部や企業と協力し、健常者を対象とした共同研究も展開しています。脳機能画像や生理学的検査を活用し、知覚・自律神経・認知機能・意思決定といったテーマを学際的に探究しています。疾患研究にとどまらず、脳とこころの理解を深め、未来社会で役立つ知見の創出と応用を目指しています。

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9．末梢神経疾患グループ

自己抗体・補体・糖鎖から病態に迫る、免疫介在性ニューロパチーのバイオマーカー研究

末梢神経・神経免疫グループは、慢性炎症性脱髄性多発根神経炎（CIDP）や自己免疫性ノドパチー、抗MAG抗体ニューロパチーなど、免疫介在性末梢神経疾患を対象とし、その病態解明と診断・治療に直結するバイオマーカーの探索に取り組んでいます。特に、自己抗体（抗NF155抗体、抗CNTN1抗体、抗Caspr1抗体、抗MAG抗体など）、補体活性、および神経細胞膜に存在する糖鎖（N結合型糖鎖、ガングリオシド、HNK-1など）に注目し、分子病態と臨床症状の関連を多角的に解析しています（Furukawa et al. Eur J Neurol. 2025; Fukami et al. Neurol Neuroimmunol Neuroinflamm 2024）。
研究手法としては、血清・髄液・末梢神経生検組織を対象とした免疫測定（ELISA、Simoaなど）、補体活性アッセイ、糖鎖解析（質量分析）、さらにはRNAシーケンスによるトランスクリプトーム解析などを駆使し、疾患特異的な分子シグネチャーを抽出しています。また、国内外の共同研究ネットワークを通じて症例コホートを集積し、臨床情報とバイオマーカーの統合解析を進めることで、精密診断と治療反応予測の実現を目指しています。 また、当教室では多くの臨床医のニーズに答えるべく、末梢神経の病理診断を佐賀大学との共同研究で行っております。最終的には、これらの知見をもとに「誰が、いつ、どの治療に最も反応するのか」を科学的に示すことで、末梢神経疾患および神経免疫疾患における個別化医療の確立に貢献することを目標としています。

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10．筋疾患グループ

臨床と多層性オミクス解析で挑む、筋疾患の謎と治療への道

筋グループでは、名大病院および関連病院からの依頼により、年間80〜100件程度の筋生検を施行し、得られた検体を診断や研究に活用しています。また、国立病院機構鈴鹿病院と協働して難治性神経筋疾患の診療に携わり、臨床現場に根ざした研究を推進しています。筋生検組織や血液を用いた病理学的評価に加え、ゲノム解析・トランスクリプトーム解析・メタボローム解析といった最新の網羅的解析を組み合わせ、病気の発症メカニズムを分子レベルで解き明かしています。これまでに、封入体筋炎（IBM）の臨床病理学的特徴や骨格筋代謝異常の解明、移植後GVHD筋炎など難治性筋疾患の特徴の同定、さらにはロボットスーツを用いたリハビリテーション効果の検討など、多角的な研究を行ってきました（kazuta et al. Ann Clin Transl Neurol 2024）。 基礎研究と臨床研究をつなぐ「トランスレーショナルリサーチ」により、診断精度の向上や新規治療法の開発に資する知見を発信し続けています。今後もさまざまな研究機関との協力を通じて、患者さんとご家族に貢献できる医療の実現を目指してまいります。

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11．神経生理グループ

豊富な検査実績と伝統ある自律神経研究に基づく、先進的神経生理学の実践

神経生理グループでは、病院における神経生理関連の臨床検査を担当するとともに、自律神経機能を中心とした研究を行っています。年間で神経伝導検査や針筋電図を約400件施行し、約350件の脳波ならびに約500件の神経生理検査の判読を行っています。さらに、医学科および検査学科の学生教育や関連病院の医師に対する研修にも対応しており、検査を通じて非常に多くの症例を学ぶ機会があります。また当グループでは、自律神経障害の検査および研究にも力を入れており、起立性低血圧の診断に重要なヘッドアップティルト試験を年間約120件実施しています。当教室における自律神経研究は全国的にも古くから知られており、約30年前には神経変性疾患におけるMIBG心筋シンチグラフィー異常を初めて報告しました。そのほかにも、自律神経障害に関する数多くの研究成果を発信しています。近年では、ウェアラブルデバイスを用いたパーキンソン病における心拍変動の研究や、自律神経機能と画像所見との関連に関する研究にも取り組んでおり、臨床に直結する知識を幅広く学ぶことができます（Suzuki et al. Parkinsonism Relat Disord 2024）。

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BIBLIOGRAPHY

2025
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2024
  1. Huggett SB, Tebbenkamp ATN, Rinaldi C, Jayaseelan D, Zampedri L, Blasi L, Fortuna A, Alqahtani A, Kokkinis A, Dahlqvist J, Fenu S, Cavalca E, Bertini A, Mariotti C, Grunseich C, Kawase T, Kishimoto Y, Yamada S, Katsuno M, Fratta P, Conte A, Sabatelli M, Soraru G, Vissing J, Kang M, Park JS, Pareyson D, Viglietta V. Functional Outcome Measures to Optimize Drug Development in Spinal and Bulbar Muscular Atrophy: Results From a Meta-Analysis of the Global SBMA Dataset. Neurology. 103(12): e210088, 2024. doi: 10.1212/WNL.0000000000210088.
  2. Furukawa G, Yoshikane A, Ishihara N, Noda S, Katsuno M, Yoshikawa T. A pediatric case of Andersen-Tawil syndrome with slowly progressive myopathy. Pediatr Int. 66(1): e15828, 2024. doi: 10.1111/ped.15828.
  3. Nishi R, Koike H, Maekawa T, Nakamura Y, Kawade Y, Tsujiuchi T, Ohno M, Fukami Y, Katsuno M, Sagisaka T. Positive Antiganglioside Antibodies in a Patient with Primary Diffuse Large B-cell Lymphoma of the Central Nervous System. Intern Med. 64(12): 1893-1899, 2024. doi: 10.2169/internalmedicine.2326-23.
  4. Ito S, Yokoi S, Fukami Y, Uchibori A, Katsuno M. Guillain-Barré syndrome with overlap between the finger drop variant and acute bulbar palsy: a case report. BMC Neurol. 24(1): 411, 2024. doi: 10.1186/s12883-024-03899-3.
  5. Obara K, Furuta T, Yagi C, Nakai N, Suzuki J, Katsuno M, Ito Y. Convexity subarachnoid hemorrhage revealed contralateral internal carotid artery dissection due to Eagle syndrome: a case report. BMC Neurol. 24(1): 380, 2024. doi: 10.1186/s12883-024-03890-y.
  6. Habib AA, Benatar M, Vu T, Meisel A, Attarian S, Katsuno M, Liao S, Beasley KN, Howard JF Jr. Time to response with ravulizumab, a long-acting terminal complement inhibitor, in adults with anti-acetylcholine receptor antibody-positive generalized myasthenia gravis. Eur J Neurol. 31(12): e16490, 2024. doi: 10.1111/ene.16490.
  7. Yamada K, Inoue T, Nakamura S, Horiuchi K, Tsutsumi Y, Munakata S, Yagi S, Fukami Y, Katsuno M, Yabe I. Chronic lymphoproliferative disorder of natural killer cells-related neurolymphomatosis with severe autonomic dysfunction: a case report. BMC Neurol. 24(1): 362, 2024. doi: 10.1186/s12883-024-03879-7.
  8. Kanda M, Kasahara Y, Shimizu D, Shinozuka T, Sasahara M, Nakamura S, Iguchi Y, Katsuno M, Kodera Y, Obika S. Dual-modified antisense oligonucleotides targeting oncogenic protocadherin to treat gastric cancer. Br J Cancer. 131(9): 1555-1566, 2024. doi: 10.1038/s41416-024-02859-5.
  9. Uematsu T, Tsuboi T, Hiraga K, Tamakoshi D, Fukushima T, Sato M, Nishida K, Yokota H, Katsuno M. Differential impact of fixation characteristics on 3D perception via texture gradient recognition in Parkinson's disease. Parkinsonism Relat Disord. 128: 107116, 2024. doi: 10.1016/j.parkreldis.2024.107116.
  10. Yanagihashi M, Hirayama T, Shibukawa M, Nagasawa J, Fujita K, Izumi Y, Morita M, Bokuda K, Takahashi K, Kanai K, Atsuta N, Iguchi Y, Katsuno M, Murakami Y, Mitsumoto H, Kano O. Reliability and consistency of the Japanese version of the Primary Lateral Sclerosis Functional Rating Scale. BMC Neurol. 24(1): 282, 2024. doi: 10.1186/s12883-024-03729-6.
  11. Obara K, Tsuboi T, Mori Y, Sanda A, Mouri N, Takagi S, Aoki S, Katsuno M. Persistence Pays: Diagnosing Tuberculous Meningitis after 11 Negative Polymerase Chain Reaction Evaluations. Intern Med. 64(6): 931-936, 2024. doi: 10.2169/internalmedicine.4087-24.
  12. Hirano M, Sahashi K, Ichikawa Y, Katsuno M, Natsume A. A rapid and easy-to-use spinal muscular atrophy screening tool based on primers with high specificity and amplification efficiency for SMN1 combined with single-stranded tag hybridization assay. PLoS One. 19(8): e0308179, 2024. doi: 10.1371/journal.pone.0308179.
  13. Hiraga K, Hattori M, Satake Y, Tamakoshi D, Fukushima T, Uematsu T, Tsuboi T, Sato M, Yokoi K, Suzuki K, Arahata Y, Washimi Y, Hori A, Yamamoto M, Shimizu H, Wakai M, Tatebe H, Tokuda T, Nakamura A, Niida S, Katsuno M. Plasma biomarkers of neurodegeneration in patients and high risk subjects with Lewy body disease. NPJ Parkinsons Dis. 10(1): 135, 2024. doi: 10.1038/s41531-024-00745-8.
  14. Mori Y, Yoshikura N, Fukami Y, Takekoshi A, Kimura A, Katsuno M, Shimohata T. Anti-contactin-associated protein 1 antibody-positive nodopathy presenting with central nervous system symptoms. J Neuroimmunol. 394: 578420, 2024. doi: 10.1016/j.jneuroim.2024.578420.
  15. Takemoto Y, Ito D, Komori S, Kishimoto Y, Yamada S, Hashizume A, Katsuno M, Nakatochi M. Comparing preprocessing strategies for 3D-Gene microarray data of extracellular vesicle-derived miRNAs. BMC Bioinformatics. 25(1): 221, 2024. doi: 10.1186/s12859-024-05840-4.
  16. Suzuki N, Mori-Yoshimura M, Katsuno M, Takahashi MP, Yamashita S, Oya Y, Hashizume A, Yamada S, Nakamori M, Izumi R, Kato M, Warita H, Tateyama M, Kuroda H, Asada R, Yamaguchi T, Nishino I, Aoki M. Safety and efficacy of aceneuramic acid in GNE myopathy: open-label extension study. J Neurol Neurosurg Psychiatry. 95(11): 1093-1094, 2024. doi: 10.1136/jnnp-2024-333853.
  17. Suzuki M, Nakamura T, Ohba C, Hatanaka M, Tsuboi T, Hirayama M, Nakatsubo D, Maesawa S, Saito R, Katsuno M. Decreased heart rate variability in sympathetic dominant states in Parkinson's disease and isolated REM sleep behavior disorder. Parkinsonism Relat Disord. 124: 107020, 2024. doi: 10.1016/j.parkreldis.2024.107020.
  18. Fujioka Y, Kawai K, Endo K, Ishibashi M, Iwade N, Tuerde D, Kaibuchi K, Yamashita T, Yamanaka A, Katsuno M, Watanabe H, Sobue G, Ishigaki S. Stress-impaired reward pathway promotes distinct feeding behavior patterns. Front Neurosci. 18: 1349366, 2024. doi: 10.3389/fnins.2024.1349366.
  19. Nishiwaki H, Ueyama J, Ito M, Hamaguchi T, Takimoto K, Maeda T, Kashihara K, Tsuboi Y, Mori H, Kurokawa K, Katsuno M, Hirayama M, Ohno K. Meta-analysis of shotgun sequencing of gut microbiota in Parkinson's disease. NPJ Parkinsons Dis. 10(1): 106, 2024. doi: 10.1038/s41531-024-00724-z.
  20. Sato T, Nagai M, Watanabe O, Misu T, Takenouchi N, Ohkubo R, Ishihara S, Tsuboi Y, Katsuno M, Nakagawa M, Matsushita T, Aso Y, Matsuura E, Tokashiki T, Mukaino A, Adachi H, Nakanishi K, Yamaguchi Y, Yamaguchi S, Yamano Y. Multicenter, randomized, double-blind, placebo-controlled phase 3 study of mogamulizumab with open-label extension study in a minimum number of patients with human T-cell leukemia virus type-1-associated myelopathy. J Neurol. 271(6): 3471-3485, 2024. doi: 10.1007/s00415-024-12239-x.
  21. Bagarinao E, Maesawa S, Kato S, Mutoh M, Ito Y, Ishizaki T, Tanei T, Tsuboi T, Suzuki M, Watanabe H, Hoshiyama M, Isoda H, Katsuno M, Sobue G, Saito R. Cerebellar and thalamic connector hubs facilitate the involvement of visual and cognitive networks in essential tremor. Parkinsonism Relat Disord. 121: 106034, 2024. doi: 10.1016/j.parkreldis.2024.106034.
  22. Hashida M, Maesawa S, Kato S, Nakatsubo D, Tsugawa T, Torii J, Tanei T, Ishizaki T, Mutoh M, Ito Y, Tsuboi T, Mizuno S, Suzuki M, Wakabayashi T, Katsuno M, Saito R. Outcomes and Prognostic Factors of Magnetic Resonance-guided Focused Ultrasound Thalamotomy for Essential Tremor at 2-year Follow-up. Neurol Med Chir (Tokyo). 64(4): 137-146, 2024. doi: 10.2176/jns-nmc.2023-0202.
  23. Yamashita S, Takahashi Y, Hashimoto J, Murakami A, Nakamura R, Katsuno M, Izumi R, Suzuki N, Warita H, Aoki M; Japan MSP Study Group. Nationwide survey of patients with multisystem proteinopathy in Japan. Ann Clin Transl Neurol. 11(4): 938-945, 2024. doi: 10.1002/acn3.52011.
  24. Iguchi Y, Takahashi Y, Li J, Araki K, Amakusa Y, Kawakami Y, Kobayashi K, Yokoi S, Katsuno M. IκB kinase phosphorylates cytoplasmic TDP-43 and promotes its proteasome degradation. J Cell Biol. 223(2): e202302048, 2024. doi: 10.1083/jcb.202302048.
  25. Fukami Y, Iijima M, Koike HH, Yagi S, Furukawa S, Mouri N, Ouchida J, Murakami A, Iida M, Yokoi S, Hashizume A, Iguchi Y, Imagama S, Katsuno M. Autoantibodies Against Dihydrolipoamide S-Acetyltransferase in Immune-Mediated Neuropathies. Neurol Neuroimmunol Neuroinflamm. 11(2): e200199, 2024. doi: 10.1212/NXI.0000000000200199.
  26. Yoshida Y, Yokoi T, Hara K, Watanabe H, Yamaguchi H, Bagarinao E, Masuda M, Kato T, Ogura A, Ohdake R, Kawabata K, Katsuno M, Kato K, Naganawa S, Okamura N, Yanai K, Sobue G. Pattern of THK 5351 retention in normal aging involves core regions of resting state networks associated with higher cognitive function. Nagoya J Med Sci. 85(4): 758-771, 2023. doi: 10.18999/nagjms.85.4.758.
  27. Shigeyama M, Nishio N, Yokoi S, Mukoyama N, Wada A, Maruo T, Noda S, Murakami A, Tsuboi T, Katsuno M, Fujimoto Y, Sone M. Efficacy of endoscopic cricopharyngeal myotomy using a curved rigid laryngoscope in patients with sporadic inclusion body myositis: four retrospective case reviews. Nagoya J Med Sci. 85(4):866-874, 2023. doi: 10.18999/nagjms.85.4.866.
  28. Senda J, Hirao R, Maeda K, Amakusa Y, Hirunagi T, Katsuno M, Kawaguchi K. Acute bilateral hypotropia and esotropia complex as first manifestation of multiple sclerosis: a case report. Nagoya J Med Sci. 85(4):822-827, 2023. doi: 10.18999/nagjms.85.4.822.
  29. Kazuta T, Murakami A, Noda S, Hirano S, Kito H, Tsujikawa K, Nakanishi H, Kimura S, Sahashi K, Koike H, Katsuno M. Clinicopathological features of graft versus host disease-associated myositis. Ann Clin Transl Neurol. 11(2):508-519, 2024. doi: 10.1002/acn3.51973.
  30. Aiba I, Hayashi Y, Shimohata T, Yoshida M, Saito Y, Wakabayashi K, Komori T, Hasegawa M, Ikeuchi T, Tokumaru AM, Sakurai K, Murayama S, Hasegawa K, Uchihara T, Toyoshima Y, Saito Y, Yabe I, Tanikawa S, Sugaya K, Hayashi K, Sano T, Takao M, Sakai M, Fujimura H, Takigawa H, Adachi T, Hanajima R, Yokota O, Miki T, Iwasaki Y, Kobayashi M, Arai N, Ohkubo T, Yokota T, Mori K, Ito M, Ishida C, Tanaka M, Idezuka J, Kanazawa M, Aoki K, Aoki M, Hasegawa T, Watanabe H, Hashizume A, Niwa H, Yasui K, Ito K, Washimi Y, Mukai E, Kubota A, Toda T, Nakashima K; J-VAC study group. Clinical course of pathologically confirmed corticobasal degeneration and corticobasal syndrome. Brain Commun. 5(6): fcad296, 2023. doi: 10.1093/braincomms/fcad296.
  31. Wada T, Doi H, Okubo M, Tada M, Ueda N, Suzuki H, Tominaga W, Koike H, Komiya H, Kubota S, Hashiguchi S, Nakamura H, Takahashi K, Kunii M, Tanaka K, Miyaji Y, Higashiyama Y, Koshimizu E, Miyatake S, Katsuno M, Fujii S, Takahashi H, Matsumoto N, Takeuchi H, Tanaka F. RNA Foci in Two bi-Allelic RFC1 Expansion Carriers. Ann Neurol. 95(3): 607-613, 2024. doi: 10.1002/ana.26848.
  32. Vu T, Wiendl H, Katsuno M, Reddel SW, Howard JF Jr. Ravulizumab in Myasthenia Gravis: A Review of the Current Evidence. Neuropsychiatr Dis Treat. 19: 2639-2655, 2023. doi: 10.2147/NDT.S374694.
  33. Ando T, Riku Y, Akagi A, Miyahara H, Uematsu T, Aiba I, Sone J, Katsuno M, Yoshida M, Iwasaki Y. Degeneration of olivospinal tract in the upper cervical spinal cord of multiple system atrophy patients: Reappraisal of Helweg's triangular tract. Brain Pathol. 34(3): e13226, 2023. doi: 10.1111/bpa.13226.
  34. Watanabe S, Murata Y, Oka Y, Oiwa K, Horiuchi M, Iguchi Y, Komine O, Sobue A, Katsuno M, Ogi T, Yamanaka K. Mitochondria-associated membrane collapse impairs TBK1-mediated proteostatic stress response in ALS. Proc Natl Acad Sci U S A. 120(47): e2315347120, 2023. doi: 10.1073/pnas.2315347120.
  35. Hirunagi T, Nakatsuji H, Sahashi K, Yamamoto M, Iida M, Tohnai G, Kondo N, Yamada S, Murakami A, Noda S, Adachi H, Sobue G, Katsuno M. Exercise attenuates polyglutamine-mediated neuromuscular degeneration in a mouse model of spinal and bulbar muscular atrophy. J Cachexia Sarcopenia Muscle. 15(1): 159-172, 2024. doi: 10.1002/jcsm.13344.
  36. Mouri N, Koike H, Fukami Y, Takahashi M, Yagi S, Furukawa S, Suzuki M, Kishimoto Y, Murate K, Nukui T, Yoshida T, Kudo Y, Tada M, Higashiyama Y, Watanabe H, Nakatsuji Y, Tanaka F, Katsuno M. Granuloma, vasculitis, and demyelination in sarcoid neuropathy. Eur J Neurol. 31(1): e16091, 2024. doi: 10.1111/ene.16091.
2023
  1. Kato S, Maesawa S, Bagarinao E, Nakatsubo D, Tsugawa T, Mizuno S, Kawabata K, Tsuboi T, Suzuki M, Shibata M, Takai S, Ishizaki T, Torii J, Mutoh M, Saito R, Wakabayashi T, Katsuno M, Ozaki N, Watanabe H, Sobue G. Magnetic resonance-guided focused ultrasound thalamotomy restored distinctive resting-state networks in patients with essential tremor. J Neurosurg. 2023;138: 306–317.
  2. Fukushima T, Ikeda S, Tomita M, Mori Y, Fukami Y, Koike H, Katsuno M, Ogata H, Isobe N, Hattori N. Demyelinating Neuropathy with Markedly Elevated Serum IgG4 Levels and Anti-Contactin 1 IgG4 Antibody. Intern Med. 62: 1341–1344, 2023
  3. Murakami A, Noda S, Kazuta T, Hirano S, Kimura S, Nakanishi H, Matsuo K, Tsujikawa K, Iida M, Koike H, Sakamoto K, Hara Y, Kuru S, Kadomatsu K, Shimamura T, Ogi T, Katsuno M. Metabolome and transcriptome analysis on muscle of sporadic inclusion body myositis. Ann Clin Transl Neurol. 9: 1602–1615, 2022
  4. Koike H, Nishi R, Yagi S, Furukawa S, Fukami Y, Iijima M, Katsuno M. A Review of Anti-IL-5 Therapies for Eosinophilic Granulomatosis with Polyangiitis. Adv Ther. 40: 25–40, 2023
  5. Ohyama K, Koike H, Tanaka M, Nosaki Y, Yokoi T, Iwai K, Katsuno M. A Bioelectrical Impedance Analysis for the Assessment of Muscle Atrophy in Patients with Chronic Inflammatory Demyelinating Polyneuropathy. Intern Med. 62: 1273–1278, 2023
  6. Torii R, Hashizume A, Yamada S, Ito D, Kishimoto Y, Moriyoshi H, Inagaki T, Nakamura R, Nakamura T, Naoi T, Morita M, Katsuno M. Clinical Features of Female Carriers and Prodromal Male Patients With Spinal and Bulbar Muscular Atrophy. Neurology. 100: e84–e93, 2023
  7. Maesawa S, Torii J, Nakatsubo D, Noda H, Mutoh M, Ito Y, Ishizaki T, Tsuboi T, Suzuki M, Tanei T, Katsuno M, Saito R. A case report: Dual-lead deep brain stimulation of the posterior subthalamic area and the thalamus was effective for Holmes tremor after unsuccessful focused ultrasound thalamotomy. Front Hum Neurosci. 16: 1065459, 2022
  8. Fukami Y, Koike H, Katsuno M. Current perspectives on the diagnosis, assessment, and management of vasculitic neuropathy. Expert Rev Neurother. 22: 941–952, 2022
  9. Senda J, Ito K, Kotake T, Mizuno M, Kishimoto H, Yasui K, Katsuno M, Nishida Y, Sobue G. Investigation of inpatient convalescent rehabilitation outcomes in branch atheromatous disease. J Stroke Cerebrovasc Dis. 32: 106937, 2023
  10. Takeuchi T, Maeta K, Ding X, Oe Y, Takeda A, Inoue M, Nagano S, Fujihara T, Matsuda S, Ishigaki S, Sahashi K, Minakawa EN, Mochizuki H, Neya M, Sobue G, Nagai Y. Sustained therapeutic benefits by transient reduction of TDP-43 using ENA-modified antisense oligonucleotides in ALS/FTD mice. Mol Ther Nucleic Acids. 31: 353–366, 2023
  11. Vu T, Ortiz S, Katsuno M, Annane D, Mantegazza R, Beasley KN, Aguzzi R, Howard JF Jr. Ravulizumab pharmacokinetics and pharmacodynamics in patients with generalized myasthenia gravis. J Neurol. 270: 3129–3137, 2023
  12. Koike H, Iguchi Y, Sahashi K, Katsuno M. Neutrophil extracellular traps: from antimicrobial innate immunity to the development of chemotherapy-induced peripheral neuropathy. EBioMedicine. 90: 104526, 2023
  13. Ueda M, Suzuki M, Hatanaka M, Nakamura T, Hirayama M, Katsuno M. Serum neurofilament light chain in patients with epilepsy and cognitive impairment. Epileptic Disord. 25: 229–236, 2023
  14. Hattori M, Hiraga K, Satake Y, Tsuboi T, Tamakoshi D, Sato M, Yokoi K, Suzuki K, Arahata Y, Hori A, Kawashima M, Shimizu H, Matsuda H, Kato K, Washimi Y, Katsuno M. Clinico-imaging features of subjects at risk of Lewy body disease in NaT-PROBE baseline analysis. NPJ Parkinsons Dis. 9: 67, 2023
  15. Meisel A, Annane D, Vu T, Mantegazza R, Katsuno M, Aguzzi R, Frick, G, Gault L, Howard Jr JF, & CHAMPION MG Study Group. Long-term efficacy and safety of ravulizumab in adults with anti-acetylcholine receptor antibody-positive generalized myasthenia gravis: results from the phase 3 CHAMPION MG open-label extension. J Neurol. 270: 3862–3875, 2023
  16. Nakamura R, Tohnai G, Nakatochi M, Atsuta N, Watanabe H, Ito D, Katsuno M, Hirakawa A, Izumi Y, Morita M, Hirayama T, Kano O, Kanai K, Hattori N, Taniguchi A, Suzuki N, Aoki M, Iwata I, Yabe I, Shibuya K, Kuwabara S, Oda M, Hashimoto R, Aiba I, Ishihara T, Onodera O, Yamashita T, Abe K, Mizoguchi K, Shimizu T, Ikeda Y, Yokota T, Hasegawa K, Tanaka F, Nakashima K, Kaji R, Niwa JI, Doyu M, Terao C, Ikegawa S, Fujimori K, Nakamura S, Ozawa F, Morimoto S, Onodera K, Ito T, Okada Y, Okano H, Sobue G; Japanese Consortium for Amyotrophic Lateral Sclerosis research (JaCALS) study group. Genetic factors affecting survival in Japanese patients with sporadic amyotrophic lateral sclerosis: a genome-wide association study and verification in iPSC-derived motor neurons from patients. J Neurol Neurosurg Psychiatry. 94: 816–824, 2023
  17. Kataoka M, Sahashi K, Tsujikawa K, Takeda JI, Hirunagi T, Iida M, Katsuno M. Dysregulation of Aldh1a2 underlies motor neuron degeneration in spinal muscular atrophy. Neurosci Res. 194: 58–65, 2023
  18. Tada T, Hara K, Fujita N, Ito Y, Yamaguchi H, Ohdake R, Kawabata K, Ogura A, Kato T, Yokoi T, Masuda M, Abe S, Miyao S, Naganawa S, Katsuno M, Watanabe H, Sobue G, Kato K. Comparative examination of the pons and corpus callosum as reference regions for quantitative evaluation in positron emission tomography imaging for Alzheimer’s disease using 11C-Pittsburgh Compound-B. Ann Nucl Med. 37: 410–418, 2023
  19. Yokoi K, Iribe Y, Kitaoka N, Tsuboi T, Hiraga K, Satake Y, Hattori M, Tanaka Y, Sato M, Hori A, Katsuno M. Analysis of spontaneous speech in Parkinson’s disease by natural language processing. Parkinsonism Relat Disord. 113: 105411, 2023
  20. Rashid MI, Ito T, Miya F, Shimojo D, Arimoto K, Onodera K, Okada R, Nagashima T, Yamamoto K, Khatun Z, Shimul RI, Niwa JI, Katsuno M, Sobue G, Okano H, Sakurai H, Shimizu K, Doyu M, Okada Y. Simple and efficient differentiation of human iPSCs into contractible skeletal muscles for muscular disease modeling. Sci Rep. 13: 8146, 2023
  21. Mitsui J, Matsukawa T, Uemura Y, Kawahara T, Chikada A, Porto KJL, Naruse H, Tanaka M, Ishiura H, Toda T, Kuzuyama H, Hirano M, Wada I, Ga T, Moritoyo T, Takahashi Y, Mizusawa H, Ishikawa K, Yokota T, Kuwabara S, Sawamoto N, Takahashi R, Abe K, Ishihara T, Onodera O, Matsuse D, Yamasaki R, Kira JI, Katsuno M, Hanajima R, Ogata K, Takashima H, Matsushima M, Yabe I, Sasaki H, Tsuji S. High-dose ubiquinol supplementation in multiple-system atrophy: a multicentre, randomised, double-blinded, placebo-controlled phase 2 trial. EClinicalMedicine. 59: 101920, 2023
  22. Vu T, Meisel A, Mantegazza R, Annane D, Katsuno M, Aguzzi R, Enayetallah A, Beasley KN, Rampal N, Howard JF Jr. Summary of Research: Terminal Complement Inhibitor Ravulizumab in Generalized Myasthenia Gravis. Neurol Ther. 12: 1435–1438, 2023
  23. Oiwa K, Watanabe S, Onodera K, Iguchi Y, Kinoshita Y, Komine O, Sobue A, Okada Y, Katsuno M, Yamanaka K. Monomerization of TDP-43 is a key determinant for inducing TDP-43 pathology in amyotrophic lateral sclerosis. Sci Adv. 9: eadf6895, 2023
  24. Mori-Yoshimura M, Suzuki N, Katsuno M, Takahashi MP, Yamashita S, Oya Y, Hashizume A, Yamada S, Nakamori M, Izumi R, Kato M, Warita H, Tateyama M, Kuroda H, Asada R, Yamaguchi T, Nishino I, Aoki M. Efficacy confirmation study of aceneuramic acid administration for GNE myopathy in Japan. Orphanet J Rare Dis. 18: 241 ,2023
  25. Schiava M, Ikenaga C, Topf A, Caballero-Ávila M, Chou TF, Li S, Wang F, Daw J, Stojkovic T, Villar-Quiles R, Nishino I, Inoue M, Nishimori Y, Saito Y, Katsuno M, Noda S, Ito C, Otsuka M, Nahir S, Manousakis G, Walk D, Quinn C, Alfano L, Sahenk Z, Tasca G, Monforte M, Sabatelli M, Bisogni G, Oldfors A, Rydeliu A, Pal E, Paradas C, Velez B, De Bleecker JL, Farugia ME, Longman C, Harms MB, Ralston S, Zanoteli E, Macedo Serafim da Silva A, Sotoca J, Juntas-Morales R, Bevilacqua J, Balart M, Talbot S, Straub V, Guglieri M, Marini-Bettolo C, Diaz-Manera J, Weihl CC. Clinical Classification of Variants in the Valosin-Containing Protein Gene Associated With Multisystem Proteinopathy. Neurol Genet. 9: e200093, 2023
  26. Tanaka S, Imaizumi T, Morohashi A, Sato K, Shibata A, Fukuta A, Nakagawa R, Nagaya M, Nishida Y, Hara K, Katsuno M, Suzuki Y, Nagao Y. In-Hospital Fall Risk Prediction by Objective Measurement of Lower Extremity Function in a High-Risk Population. J Am Med Dir Assoc. 24: 1861–1867.e2, 2023
  27. Yamada S, Katsuno M. Preimplantation Genetic Testing for Monogenic Disorders: The Role of Neurologists and Challenges. Brain Nerve. 75: 1051–1056, 2023
  28. Senda J, Ito K, Kotake T, Mizuno M, Kishimoto H, Yasui K, Nakagawa-Senda H, Katsuno M, Nishida Y, Sobue G. Association between National Institutes of Health Stroke Scale and Functional Independence Measure scores in patients with ischemic stroke from convalescent rehabilitation outcomes. Nagoya J Med Sci. 85: 428–443, 2023
  29. Mouri N, Koike H, Fukami Y, Takahashi M, Yagi S, Furukawa S, Suzuki M, Kishimoto Y, Murate K, Nukui T, Yoshida T, Kudo Y, Tada M, Higashiyama Y, Watanabe H, Nakatsuji Y, Tanaka F, Katsuno M. Granuloma, vasculitis, and demyelination in sarcoid neuropathy. Eur J Neurol. 31: e16091, 2024
  30. Watanabe S, Murata Y, Oka Y, Oiwa K, Horiuchi M, Iguchi Y, Komine O, Sobue A, Katsuno M, Ogi T, Yamanaka K. Mitochondria-associated membrane collapse impairs TBK1-mediated proteostatic stress response in ALS. Proc Natl Acad Sci U S A. 120: e2315347120, 2023
  31. Ando T, Riku Y, Akagi A, Miyahara H, Uematsu T, Aiba I, Sone J, Katsuno M, Yoshida M, Iwasaki Y. Degeneration of olivospinal tract in the upper cervical spinal cord of multiple system atrophy patients: Reappraisal of Helweg’s triangular tract. Brain Pathol. 34: e13226, 2024
  32. Fuse K, Araki A, Morozumi S, Yasui K, Kazuta T, Noda S, Katsuno M. A case of anti-acetylcholine receptor antibody-positive ocular myasthenia gravis with anti-titin antibody and anti-Kv1.4 antibody positive inflammatory myopathy. Rinsho Shinkeigaku. 63: 830–835, 2023
  33. Vu T, Wiendl H, Katsuno M, Reddel SW, Howard JF Jr. Ravulizumab in Myasthenia Gravis: A Review of the Current Evidence. Neuropsychiatr Dis Treat. 19: 2639–2655, 2023
  34. Senda J, Hirao R, Maeda K, Amakusa Y, Hirunagi T, Katsuno M, Kawaguchi K. Acute bilateral hypotropia and esotropia complex as first manifestation of multiple sclerosis: a case report. Nagoya J Med Sci. 85: 822–827, 2023
  35. Shigeyama M, Nishio N, Yokoi S, Mukoyama N, Wada A, Maruo T, Noda S, Murakami A, Tsuboi T, Katsuno M, Fujimoto Y, Sone M. Efficacy of endoscopic cricopharyngeal myotomy using a curved rigid laryngoscope in patients with sporadic inclusion body myositis: four retrospective case reviews. Nagoya J Med Sci. 85: 866–874, 2023
  36. Yoshida Y, Yokoi T, Hara K, Watanabe H, Yamaguchi H, Bagarinao E, Masuda M, Kato T, Ogura A, Ohdake R, Kawabata K, Katsuno M, Kato K, Naganawa S, Okamura N, Yanai K, Sobue G. ＜Editors’ Choice＞ Pattern of THK 5351 retention in normal aging involves core regions of resting state networks associated with higher cognitive function. Nagoya J Med Sci. 85: 758–771, 2023
2022
  1. Hsueh HW, Chao CC, Chang K, Jeng YM, Katsuno M, Koike H, Hsieh ST. Unique Phenotypes With Corresponding Pathology in Late-Onset Hereditary Transthyretin Amyloidosis of A97S vs. V30M. Front Aging Neurosci. 13: 786322, 2022
  2. Kurata K, Hosono K, Takayama M, Katsuno M, Saitsu H, Ogata T, Hotta Y. Retinitis pigmentosa with optic neuropathy and COQ2 mutations: A case report. Am J Ophthalmol Case Rep. 25: 101298, 2022
  3. Hirunagi T, Sahashi K, Meilleur KG, Katsuno M. Nucleic Acid-Based Therapeutic Approach for Spinal and Bulbar Muscular Atrophy and Related Neurological Disorders. Genes (Basel). 13: 109, 2022
  4. Ando T, Riku Y, Akagi A, Miyahara H, Hirano M, Ikeda T, Yabata H, Koizumi R, Oba C, Morozumi S, Yasui K, Goto A, Katayama T, Sakakibara S, Aiba I, Sakai M, Konagaya M, Mori K, Ito Y, Yuasa H, Nomura M, Porto KJL, Mitsui J, Tsuji S, Mimuro M, Hashizume Y, Katsuno M, Iwasaki Y, Yoshida M. Multiple system atrophy variant with severe hippocampal pathology. Brain Pathol. 32: e13002, 2022
  5. Bagarinao E, Watanabe H, Maesawa S, Kawabata K, Hara K, Ohdake R, Ogura A, Mori D, Yoneyama N, Imai K, Yokoi T, Kato T, Koyama S, Katsuno M, Wakabayashi T, Kuzuya M, Hoshiyama M, Isoda H, Naganawa S, Ozaki N, Sobue G. Reserve and Maintenance in the Aging Brain: A Longitudinal Study of Healthy Older Adults. eNeuro. 9: 0455-21, 2022.
  6. Ogura A, Kawabata K, Watanabe H, Choy SW, Bagarinao E, Kato T, Imai K, Masuda M, Ohdake R, Hara K, Nakamura R, Atsuta N, Nakamura T, Katsuno M, Sobue G. Fiber-specific white matter analysis reflects upper motor neuron impairment in amyotrophic lateral sclerosis. Eur J Neurol. 29: 432-440, 2022
  7. Aizawa H, Kato H, Oba K, Kawahara T, Okubo Y, Saito T, Naito M, Urushitani M, Tamaoka A, Nakamagoe K, Ishii K, Kanda T, Katsuno M, Atsuta N, Maeda Y, Nagai M, Nishiyama K, Ishiura H, Toda T, Kawata A, Abe K, Yabe I, Takahashi-Iwata I, Sasaki H, Warita H, Aoki M, Sobue G, Mizusawa H, Matsuyama Y, Haga T, Kwak S. Randomized phase 2 study of perampanel for sporadic amyotrophic lateral sclerosis. J Neurol. 269: 885-896, 2022
  8. Masuda M, Watanabe H, Ogura A, Ohdake R, Kato T, Kawabata K, Hara K, Nakamura R, Atsuta N, Epifanio B, Katsuno M, Sobue G. Clinicoradiological features in amyotrophic lateral sclerosis patients with olfactory dysfunction. Amyotroph Lateral Scler Frontotemporal Degener. 22: 260-266, 2022
  9. Katsuno M. What and How to Study in Graduate School. Brain Nerve. 74: 25–28, 2022
  10. Tohnai G, Nakamura R, Atsuta N, Nakatochi M, Hayashi N, Ito D, Watanabe H, Watanabe H, Katsuno M, Izumi Y, Taniguchi A, Kanai K, Morita M, Kano O, Kuwabara S, Oda M, Abe K, Aoki M, Aiba I, Okamoto K, Mizoguchi K, Ishihara T, Kawata A, Yokota T, Hasegawa K, Nagano I, Yabe I, Tanaka F, Kuru S, Hattori N, Nakashima K, Kaji R, Sobue G; Japanese Consortium for Amyotrophic Lateral Sclerosis Research (JaCALS). Mutation screening of the DNAJC7 gene in Japanese patients with sporadic amyotrophic lateral sclerosis. Neurobiol Aging. 113: 131–136, 2022
  11. Hashizume A, Katsuno M. Novel concept to evaluate efficacy of therapeutics for ALS based on patient preference. Journal of neurology, neurosurgery, and psychiatry. p. 457, 2022
  12. Koike H, Nishi R, Ohyama K, Morozumi S, Kawagashira Y, Furukawa S, Mouri N, Fukami Y, Iijima M, Sobue G, Katsuno M. ANCA-Associated Vasculitic Neuropathies: A Review. Neurol Ther. 11: 21–38, 2022
  13. Ikenaka K, Maeda Y, Hotta Y, Nagano S, Yamada S, Ito D, Torii R, Kakuda K, Tatebe H, Atsuta N, Aguirre C, Kimura Y, Baba K, Tokuda T, Katsuno M, Kimura K, Sobue G, Mochizuki H. Serum asymmetric dimethylarginine level correlates with the progression and prognosis of amyotrophic lateral sclerosis. Eur J Neurol. 29: 1410–1416, 2022
  14. Riku Y, Iwasaki Y, Ishigaki S, Akagi A, Hasegawa M, Nishioka K, Li Y, Riku M, Ikeuchi T, Fujioka Y, Miyahara H, Sone J, Hattori N, Yoshida M, Katsuno M, Sobue G. Motor neuron TDP-43 proteinopathy in progressive supranuclear palsy and corticobasal degeneration. Brain. 145: 2769–2784, 2022
  15. Ando T, Wakai M, Kanbayashi T, Katsuno M. Status Cataplecticus with Rapid Eye Movement Sleep Excess in Late-onset Narcolepsy Type 1. Intern Med. 61: 2951–2955, 2022
  16. Kishimoto Y, Hashizume A, Imai Y, Nakatochi M, Yamada S, Ito D, Torii R, Nagano Y, Fujimoto H, Katsuno M. Quantitative evaluation of upper limb ataxia in spinocerebellar ataxias. Ann Clin Transl Neurol. 9: 529–539, 2022
  17. Ando T, Riku Y, Akagi A, Miyahara H, Sone J, Katsuno M, Yoshida M, Iwasaki Y. Clinical diagnosis sensitivity of neuropathologically established multiple system atrophy in Japan. Journal of neurology. 5162–5164, 2022
  18. Koike H, Nishi R, Furukawa S, Mouri N, Fukami Y, Iijima M, Katsuno M. In vivo visualization of eosinophil secretion in eosinophilic granulomatosis with polyangiitis: An ultrastructural study. Allergol Int. 2022;71: 373–382.
  19. Koike H, Furukawa S, Mouri N, Fukami Y, Iijima M, Katsuno M. Dosage effects of PMP22 on nonmyelinating Schwann cells in hereditary neuropathy with liability to pressure palsies. Neuromuscul Disord. 32: 503–511, 2022
  20. Kawabata K, Bagarinao E, Watanabe H, Maesawa S, Mori D, Hara K, Ohdake R, Masuda M, Ogura A, Kato T, Koyama S, Katsuno M, Wakabayashi T, Kuzuya M, Hoshiyama M, Isoda H, Naganawa S, Ozaki N, Sobue G. Functional connector hubs in the cerebellum. Neuroimage. 257: 119263, 2022
  21. Yokoi S, Nishio N, Maruo T, Hiramatsu M, Mukoyama N, Tsuzuki H, Wada A, Atsuta N, Ito D, Tsuboi T, Sobue G, Katsuno M, Fujimoto Y, Sone M. Safety and Clinical Benefits of Laryngeal Closure in Patients with Amyotrophic Lateral Sclerosis. Dysphagia. 38: 211–219, 2023
  22. Ito Y, Fujita N, Hara K, Tada T, Abe S, Katsuno M, Naganawa S, Kato K. Novel approach to semi-quantification of tracer accumulation in dopamine transporter scan. J Appl Clin Med Phys. 23: e13626, 2022
  23. Fukami Y, Koike H, Iijima M, Mouri N, Nishi R, Katsuno M. Role of complement components in vasculitic neuropathy associated with systemic lupus erythematosus and rheumatoid arthritis. Muscle Nerve. 66: 175–182, 2022
  24. Ando T, Kamoshita S, Riku Y, Ito A, Ozawa Y, Miyamura K, Fujino M, Ito M, Goto Y, Mano K, Akagi A, Miyahara H, Katsuno M, Yoshida M, Iwasaki Y. Neurolymphomatosis in follicular lymphoma: an autopsy case report. Neuropathology. 42: 295–301, 2022
  25. Tsujikawa K, Hamanaka K, Riku Y, Hattori Y, Hara N, Iguchi Y, Ishigaki S, Hashizume A, Miyatake S, Mitsuhashi S, Miyazaki Y, Kataoka M, Jiayi L, Yasui K, Kuru S, Koike H, Kobayashi K, Sahara N, Ozaki N, Yoshida M, Kakita A, Saito Y, Iwasaki Y, Miyashita A, Iwatsubo T; Japanese Alzheimer’s Disease Neuroimaging Initiative (J-ADNI); Ikeuchi T; Japanese Longitudinal Biomarker Study in PSP and CBD (JALPAC) Consortium; Miyata T, Sobue G, Matsumoto N, Sahashi K, Katsuno M. Actin-binding protein filamin-A drives tau aggregation and contributes to progressive supranuclear palsy pathology. Sci Adv. 8: eabm5029, 2022
  26. Nishiwaki H, Ito M, Hamaguchi T, Maeda T, Kashihara K, Tsuboi Y, Ueyama J, Yoshida T, Hanada H, Takeuchi I, Katsuno M, Hirayama M, Ohno K. Short chain fatty acids-producing and mucin-degrading intestinal bacteria predict the progression of early Parkinson’s disease. NPJ Parkinsons Dis. 8: 65, 2022
  27. Mochizuki H, Aoki M, Ikenaka K, Inoue H, Iwatsubo T, Ugawa Y, Okazawa H, Ono K, Onodera O, Kitagawa K, Saito Y, Shimohata T, Takahashi R, Toda T, Nakahara J, Matsumoto R, Mizusawa H, Mitsui J, Murayama S, Katsuno M; Future Vision Committee of Japanese Society of Neurology; Aoki Y, Ishiura H, Izumi Y, Koike H, Shimada H, Takahashi Y, Tokuda T, Nakajima H, Hatano T, Misawa S, Watanabe H. Recommendations (Proposal) for promoting research for overcoming neurological diseases 2020. Rinsho Shinkeigaku. 62: 443–457, 2022
  28. Tsuboi T, Satake Y, Hiraga K, Yokoi K, Hattori M, Suzuki M, Hara K, Ramirez-Zamora A, Okun MS, Katsuno M. Effects of MAO-B inhibitors on non-motor symptoms and quality of life in Parkinson’s disease: A systematic review. NPJ Parkinsons Dis. 8: 75, 2022
  29. Noda S, Murakami A, Kazuta T, Hirano S, Kimura S, Nakanishi H, Matsuo K, Tsujikawa K, Yamada S, Iida M, Koike H, Kuru S, Katsuno M. Clinical implication of denervation in sporadic inclusion body myositis. J Neurol Sci. 439: 120317, 2022
  30. Koike H, Furukawa S, Mouri N, Fukami Y, Iijima M, Katsuno M. Early ultrastructural lesions of anti-neutrophil cytoplasmic antibody- versus complement-associated vasculitis. Neuropathology. 42: 420–429, 2022
  31. Imai Y, Iida M, Kanie K, Katsuno M, Kato R. Label-free morphological sub-population cytometry for sensitive phenotypic screening of heterogenous neural disease model cells. Sci Rep. 12: 9296, 2022
  32. Nakatsuji H, Ikeda T, Hashizume A, Katsuno M, Sobue G, Nakajima T. The Combined Efficacy of a Two-Year Period of Cybernic Treatment With a Wearable Cyborg Hybrid-Assistive Limb and Leuprorelin Therapy in a Patient With Spinal and Bulbar Muscular Atrophy: A Case Report. Front Neurol. 13: 905613, 2022
  33. Ogura Y, Sahashi K, Hirunagi T, Iida M, Miyata T, Katsuno M. Mid1 is associated with androgen-dependent axonal vulnerability of motor neurons in spinal and bulbar muscular atrophy. Cell Death Dis. 13: 601, 2022
  34. Suzuki M, Nakamura T, Hirayama M, Ueda M, Hatanaka M, Harada Y, Nakatochi M, Nakatsubo D, Maesawa S, Saito R, Fujiwara K, Katsuno M. Wearable sensor device-based detection of decreased heart rate variability in Parkinson’s disease. J Neural Transm. 129: 1299–1306, 2022
  35. Komori S, Tsuboi T, Suzuki M, Nakamura T, Katsuno M. Dyskinesia-hyperpyrexia syndrome triggered by overdose of istradefylline: a case report. Rinsho Shinkeigaku. 62: 627–631, 2022
  36. Okuma A, Nakamura T, Katsuno M, Matsushita T. Elucidation of peripheral nerve myelination by bimodal waveform analysis. J Neurol Sci. 440: 120346, 2022
  37. Daida K, Shimonaka S, Shiba-Fukushima K, Ogata J, Yoshino H, Okuzumi A, Hatano T, Motoi Y, Hirunagi T, Katsuno M, Shindou H, Funayama M, Nishioka K, Hattori N, Imai Y. α-Synuclein V15A Variant in Familial Parkinson’s Disease Exhibits a Weaker Lipid-Binding Property. Mov Disord. 37: 2075–2085, 2022
  38. Kato S, Bagarinao E, Isoda H, Koyama S, Watanabe H, Maesawa S, Hara K, Katsuno M, Naganawa S, Ozaki N, Sobue G. Reproducibility of functional connectivity metrics estimated from resting-state functional MRI with differences in days, coils, and global signal regression. Radiol Phys Technol. 15: 298–310, 2022
  39. Ohno K, Hirayama M. Ascendance of Abnormal α-synuclein Fibrils Through the Vagal Nerve in Parkinson’s Disease. Brain Nerve. 74: 979–984, 2022
  40. Kiryu-Seo S, Matsushita R, Tashiro Y, Yoshimura T, Iguchi Y, Katsuno M, Takahashi R, Kiyama H. Impaired disassembly of the axon initial segment restricts mitochondrial entry into damaged axons. EMBO J. 41: e110486, 2022
  41. Ohdake R, Watanabe H, Kawabata K, Ogura A, Sato M, Tanaka Y, Imai K, Masuda M, Kato T, Yokoi T, Hara K, Nakamura R, Atsuta N, Nakagawa M, Katsuno M, Sobue G. Convenient Auditory-Based Language and Executive Function Test for Patients With Amyotrophic Lateral Sclerosis: A Pilot Study. Arch Clin Neuropsychol. 38: 57–71, 2023
  42. Bagarinao E, Kawabata K, Watanabe H, Hara K, Ohdake R, Ogura A, Masuda M, Kato T, Maesawa S, Katsuno M, Sobue G. Connectivity impairment of cerebellar and sensorimotor connector hubs in Parkinson’s disease. Brain Commun. 4: fcac214, 2022
  43. Yamada S, Hashizume A, Hijikata Y, Inagaki T, Ito D, Kishimoto Y, Kinoshita F, Hirakawa A, Shimizu S, Nakamura T, Katsuno M. Mexiletine in spinal and bulbar muscular atrophy: a randomized controlled trial. Ann Clin Transl Neurol. 9: 1702–1714, 2022
  44. Kunitake K, Ogura A, Iwata-Hatanaka M, Inagaki R, Furukawa S, Suzuki J, Nakai N, Nishida S, Katsuno M, Ito Y. Persistent brain damage in reversible cerebral vasoconstriction syndrome on 99mTc-ethyl cysteinate dimer single-photon emission computed tomography: A long-term observational study. J Neurol Sci. 442: 120441, 2022
  45. Iwayama H, Ishihara N, Kawahara K, Madokoro Y, Togawa Y, Muramatsu K, Murakami A, Kuru S, Kumagai T, Ohashi W, Nanya K, Hasegawa S, Katsuno M, Okumura A. Early immunological responses to the mRNA SARS-CoV-2 vaccine in patients with neuromuscular disorders. Front Immunol. 13: 996134, 2022
  46. Inagaki T, Hashizume A, Hijikata Y, Yamada S, Ito D, Kishimoto Y, Torii R, Sato H, Hirakawa A, Katsuno M. Development of a functional composite for the evaluation of spinal and bulbar muscular atrophy. Sci Rep. 12: 17443, 2022.
  47. Yokoi S, Ito T, Sahashi K, Nakatochi M, Nakamura R, Tohnai G, Fujioka Y, Ishigaki S, Udagawa T, Izumi Y, Morita M, Kano O, Oda M, Sone T, Okano H, Atsuta N, Katsuno M, Okada Y, Sobue G. The SYNGAP1 3’UTR Variant in ALS Patients Causes Aberrant SYNGAP1 Splicing and Dendritic Spine Loss by Recruiting HNRNPK. J Neurosci. 42: 8881–8896, 2022
  48. Shizuku M, Kurata N, Jobara K, Tanaka T, Fukuta A, Hatanaka Iwata M, Hara K, Katsuno M, Nakano H, Ogura Y. Recovery From Severe Systemic Peripheral Neuropathy Secondary to Erythropoietic Protoporphyria by Liver Transplant: A Case Report. Exp Clin Transplant. 20: 954–958, 2022
  49. Ando T, Watanabe H, Riku Y, Yoshida M, Goto Y, Ando R, Fujino M, Ito M, Koike H, Katsuno M, Iwasaki Y. Neurogenic intermittent claudication caused by vasculitis in the cauda equina: an autopsy case report. Eur Spine J. 32: 2602–2606, 2023
  50. Nishiwaki H, Ueyama J, Kashihara K, Ito M, Hamaguchi T, Maeda T, Tsuboi Y, Katsuno M, Hirayama M, Ohno K. Gut microbiota in dementia with Lewy bodies. NPJ Parkinsons Dis. 8: 169, 2022
  51. Sahashi K, Hashizume A, Kuwatsuka Y, Chinen M, Saotome-Nakamura A, Ando M, Katsuno M. The Japan Registry for Adult Subjects of Spinal Muscular Atrophy (jREACT-SMA): Protocol for a Longitudinal Observational Study. JMIR Res Protoc. 11: e38878, 2022
  52. Riku Y, Yoshida M, Iwasaki Y, Sobue G, Katsuno M, Ishigaki S. TDP-43 Proteinopathy and Tauopathy: Do They Have Pathomechanistic Links? Int J Mol Sci. 23. doi:10.3390/ijms232415755, 2022
2021
  1. Nishi R, Koike H, Ohyama K, Fukami Y, Iijima M, Sobue G, Katsuno M. Association Between IL-5 Levels and the Clinicopathologic Features of Eosinophilic Granulomatosis With Polyangiitis. Neurology. 96: 226-229, 2021
  2. Furukawa S, Kunii M, Doi H, Kondo N, Ogura A, Hirabuki K, Itoh T, Matsumoto N, Tanaka F, Katsuno M, Ito Y. Case Report: Severe Osteoporosis and Preventive Therapy in RNA Polymerase III-Related Leukodystrophy. Front Neurol. 12: 622355, 2021
  3. Harada Y, Sheng S, Thombre VA, Ounpraseuth S, Tommee CG, Annapureddy AR, Kamran M, Jasti MS, Katsuno M, Yadala S, Veerapaneni K, Kapoor N, Kovvuru S, Onteddu SR, Nalleballe K. A neuromuscular-based analysis of the open payments program. Muscle Nerve. 63: 96-99, 2021
  4. Tsuboi T, Charbel M, Peterside DT, Rana M, Elkouzi A, Deeb W, Ramirez-Zamora A, Lemos Melo Lobo Jofili Lopes J, Almeida L, Zeilman PR, Eisinger RS, Foote KD, Okromelidze L, Grewal SS, Okun MS, Middlebrooks EH. Pallidal Connectivity Profiling of Stimulation-Induced Dyskinesia in Parkinson's Disease. Mov Disord. 36: 380-388, 2021
  5. Hirunagi T, Sahashi K, Tachikawa K, Leu AI, Nguyen M, Mukthavaram R, Karmali PP, Chivukula P, Tohnai G, Iida M, Onodera K, Ohyama M, Okada Y, Okano H, Katsuno M. Selective suppression of polyglutamine-expanded protein by lipid nanoparticle-delivered siRNA targeting CAG expansions in the mouse CNS. Mol Ther Nucleic Acids. 24: 1-10, 2021
  6. Nakamura R, Tohnai G, Atsuta N, Nakatochi M, Hayashi N, Watanabe H, Yokoi D, Watanabe H, Katsuno M, Izumi Y, Taniguchi A, Kanai K, Morita M, Kano O, Kuwabara S, Oda M, Abe K, Aoki M, Aiba I, Okamoto K, Mizoguchi K, Hattori N, Nakashima K, Kaji R, Sobue G; Japanese Consortium for Amyotrophic Lateral Sclerosis Research (JaCALS). Genetic and functional analysis of KIF5A variants in Japanese patients with sporadic amyotrophic lateral sclerosis. Neurobiol Aging. 97: e11-147.e17, 2021
  7. Koike H, Mouri N, Fukami Y, Iijima M, Matsuo K, Yagi N, Saito A, Nakamura H, Takahashi K, Nakae Y, Okada Y, Tanaka F, Sobue G, Katsuno M. Two distinct mechanisms of neuropathy in immunoglobulin light chain (AL) amyloidosis. J Neurol Sci. 421: 117305, 2021
  8. Hayashi N, Sone J, Fukami Y, Yoshida Y, Kuno S, Shimada K, Atsuta N, Nakamura T, Higuchi O, Katsuno M. Severe myasthenia gravis with anti-LRP4 antibodies and Hodgkin lymphoma. Muscle Nerve. 63: E2-E4, 2021
  9. Kusama K, Nakae Y, Tada M, Higashiyama Y, Miyaji Y, Yamaura G, Kunii M, Tanaka K, Ohyama K, Koike H, Joki H, Doi H, Koyano S, Tanaka F. Hepatitis B Virus-related Vasculitic Neuropathy in an Inactive Virus Carrier Treated with Intravenous Immunoglobulin. Intern Med. 59: 3075-3078, 2021
  10. Ueda M, Sekijima Y, Koike H, Yamashita T, Yoshinaga T, Ishii T, Ando Y. Monitoring of asymptomatic family members at risk of hereditary transthyretin amyloidosis for early intervention with disease-modifying therapies. J Neurol Sci. 414: 116813, 202
  11. Koike H, Katsuno M. Macrophages and Autoantibodies in Demyelinating Diseases. Cells. 10: 844, 2021
  12. Riku Y, Seilhean D, Duyckaerts C, Boluda S, Iguchi Y, Ishigaki S, Iwasaki Y, Yoshida M, Sobue G, Katsuno M. Pathway from TDP-43-Related Pathology to Neuronal Dysfunction in Amyotrophic Lateral Sclerosis and Frontotemporal Lobar Degeneration. Int J Mol Sci. 22: 3843, 2021
  13. Ando T, Nakamura R, Kuru S, Yokoi D, Atsuta N, Koike H, Suzuki M, Hara K, Iguchi Y, Harada Y, Yoshida Y, Hattori M, Murakami A, Noda S, Kimura S, Sone J, Nakamura T, Goto Y, Mano K, Okada H, Okuda S, Nishino I, Ogi T, Sobue G, Katsuno M. The wide-ranging clinical and genetic features in Japanese families with valosin-containing protein proteinopathy. Neurobiol Aging. 100: 120.e1-120.e6, 2021
  14. Lövestam S, Schweighauser M, Matsubara T, Murayama S, Tomita T, Ando T, Hasegawa K, Yoshida M, Tarutani A, Hasegawa M, Goedert M, Scheres SHW. Seeded assembly in vitro does not replicate the structures of α-synuclein filaments from multiple system atrophy. FEBS Open Bio. 11: 999-1013, 2021
  15. Wong JK, Hu W, Barmore R, Lopes J, Moore K, Legacy J, Tahafchi P, Jackson Z, Judy JW, Raike RS, Wang A, Tsuboi T, Okun MS, Almeida L. Safety and Tolerability of Burst-Cycling Deep Brain Stimulation for Freezing of Gait in Parkinson's Disease. Front Hum Neurosci. 15: 651168, 2021
  16. Homma H, Tanaka H, Jin M, Jin X, Huang Y, Yoshioka Y, Bertens CJ, Tsumaki K, Kondo K, Shiwaku H, Tagawa K, Akatsu H, Atsuta N, Katsuno M, Furukawa K, Ishiki A, Waragai M, Ohtomo G, Iwata A, Yokota T, Inoue H, Arai H, Sobue G, Sone M, Fujita K, Okazawa. DNA damage in embryonic neural stem cell determines FTLDs' fate via early-stage neuronal necrosis. Life Sci Alliance. 4: e202101022, 2021
  17. Li J, Durose WW, Ito J, Kakita A, Iguchi Y, Katsuno M, Kunisawa K, Shimizu T, Ikenaka K. Exploring the factors underlying remyelination arrest by studying the post-transcriptional regulatory mechanisms of cystatin F gene. J Neurochem. 157: 2070-2090, 202
  18. Koike H, Katsuno M. The Ultrastructure of Tissue Damage by Amyloid Fibrils. Molecules. 26: 4611, 2021
  19. Kumutpongpanich T, Ogasawara M, Ozaki A, Ishiura H, Tsuji S, Minami N, Hayashi S, Noguchi S, Iida A, Nishino I; OPDM_LRP12 Study Group; Mori-Yoshimura M, Oya Y, Ono K, Shimizu T, Kawata A, Shimohama S, Toyooka K, Endo K, Toru S, Sasaki O, Isahaya K, Takahashi MP, Iwasa K, Kira JI, Yamamoto T, Kawamoto M, Hamano T, Sugie K, Eura N, Shiota T, Koide M, Sekiya K, Kishi H, Hideyama T, Kawai S, Yanagimoto S, Sato H, Arahata H, Murayama S, Saito K, Hara H, Kanda T, Yaguchi H, Imai N, Kawagashira Y, Sanada M, Obara K, Kaido M, Furuta M, Kurashige T, Hara W, Kuzume D, Yamamoto M, Tsugawa J, Kishida H, Ishizuka N, Morimoto K, Tsuji Y, Tsuneyama A, Matsuno A, Sasaki R, Tamakoshi D, Abe E, Yamada S, Uzawa A. Clinicopathologic Features of Oculopharyngodistal Myopathy With LRP12 CGG Repeat Expansions Compared With Other Oculopharyngodistal Myopathy Subtypes. JAMA Neurol. 78: 853-863, 2021
  20. Tsuboi T, Wong JK, Eisinger RS, Okromelidze L, Burns MR, Ramirez-Zamora A, Almeida L, Wagle Shukla A, Foote KD, Okun MS, Grewal SS, Middlebrooks EH. Comparative connectivity correlates of dystonic and essential tremor deep brain stimulation. Brain. 144: 1774-1786, 2021
  21. Kawabata K, Bagarinao E, Watanabe H, Maesawa S, Mori D, Hara K, Ohdake R, Masuda M, Ogura A, Kato T, Koyama S, Katsuno M, Wakabayashi T, Kuzuya M, Hoshiyama M, Isoda H, Naganawa S, Ozaki N, Sobue G. Bridging large-scale cortical networks: Integrative and function-specific hubs in the thalamus. iScience. 24: 103106, 2021
  22. Ebina J, Hara K, Watanabe H, Kawabata K, Yamashita F, Kawaguchi A, Yoshida Y, Kato T, Ogura A, Masuda M, Ohdake R, Mori D, Maesawa S, Katsuno M, Kano O, Sobue G. Individual voxel-based morphometry adjusting covariates in multiple system atrophy. Parkinsonism Relat Disord. 90: 114-119, 2021
  23. Kanda M, Shimizu D, Nakamura S, Sawaki K, Umeda S, Miwa T, Tanaka H, Inokawa Y, Hattori N, Hayashi M, Tanaka C, Nakayama G, Iguchi Y, Katsuno M, Kodera Y. Blockade of CHRNB2 signaling with a therapeutic monoclonal antibody attenuates the aggressiveness of gastric cancer cells. Oncogene. 40: 5495-5504,2021
  24. Ando T, Sato T, Kurahashi S, Kawaguchi Y, Kagaya Y, Ozawa Y, Hirano S, Goto Y, Mano K, Yokoi S, Nakamura T, Murakami A, Noda S, Kimura S, Sone J, Kuru S, Sobue G, Katsuno M. A case of sporadic late-onset nemaline myopathy with monoclonal gammopathy of undetermined significance: long-term observation of neurological symptoms after autologous stem-cell transplantation. Nagoya J Med Sci. 83: 641-647, 2021
  25. Koike H, Iguchi Y, Sahashi K, Katsuno M. Significance of Oligomeric and Fibrillar Species in Amyloidosis: Insights into Pathophysiology and Treatment. Molecules. 26: 5091, 2021
  26. Koike H, Katsuno M. Emerging infectious diseases, vaccines and Guillain-Barré syndrome. Neurol Ther. 10: 523-537, 2021
  27. Harada Y, Nakamura T, Suzuki M, Ueda M, Hirayama M, Katsuno M. Impaired pain processing and its association with attention disturbance in patients with amyotrophic lateral sclerosis. Neurol Sci. 42: 3327-3335, 2021
  28. Holanda VM, Eisinger RS, Almeida L, Tsuboi T, Wang H, Okun MS, Deeb W, Patterson A, Wagle Shukla A, Lobo Lopes J, Foote KD. Evolution of Globus Pallidus Targeting for Parkinson's and Dystonia Deep Brain Stimulation: A 15-Year Experience. Front Neurol. 12: 679918, 2021.
  29. Ando T, Yokoi F, Riku Y, Akagi A, Miyahara H, Hasegawa M, Katsuno M, Yoshida M, Iwasaki Y. The hot cross bun sign in corticobasal degeneration. Neuropathology. 41: 376-380, 2021
  30. Fukami Y, Iijima M, Koike H, Yamada S, Hashizume A, Katsuno M. Association of serum neurofilament light chain levels with clinicopathology of chronic inflammatory demyelinating polyneuropathy, including NF155 reactive patients. J Neurol. 268: 3835-3844, 2021
  31. Yamada S, Hashizume A, Hijikata Y, Ito D, Kishimoto Y, Iida M, Koike H, Hirakawa A, Katsuno M. Ratio of urinary N-terminal titin fragment to urinary creatinine is a novel biomarker for amyotrophic lateral sclerosis. J Neurol Neurosurg Psychiatry. 92: 1072-1079, 2021
  32. Middlebrooks EH, Okromelidze L, Wong JK, Eisinger RS, Burns MR, Jain A, Lin HP, Yu J, Opri E, Horn A, Goede LL, Foote KD, Okun MS, Quiñones-Hinojosa A, Uitti RJ, Grewal SS, Tsuboi T. Connectivity correlates to predict essential tremor deep brain stimulation outcome: Evidence for a common treatment pathway. Neuroimage Clin. 32: 102846, 2021
  33. Watanabe H, Bagarinao E, Maesawa S, Hara K, Kawabata K, Ogura A, Ohdake R, Shima S, Mizutani Y, Ueda A, Ito M, Katsuno M, Sobue G. Characteristics of Neural Network Changes in Normal Aging and Early Dementia. Front Aging Neurosci. 13: 747359, 2021
  34. Maesawa S, Mizuno S, Bagarinao E, Watanabe H, Kawabata K, Hara K, Ohdake R, Ogura A, Mori D, Nakatsubo D, Isoda H, Hoshiyama M, Katsuno M, Saito R, Ozaki N, Sobue G. Resting State Networks Related to the Maintenance of Good Cognitive Performance During Healthy Aging. Front Hum Neurosci. 15: 753836, 2021
  35. Koike H, Katsuno M. Paraproteinemia and neuropathy. Neurol Sci. 42: 4489-4501, 2021
  36. Sommer C, Carroll AS, Koike H, Katsuno M, Ort N, Sobue G, Vucic S, Spies JM, Doppler K, Kiernan MC. Nerve biopsy in acquired neuropathies. J Peripher Nerv Syst. 26: S21-S41, 2021
  37. Oishi M, Mukaino A, Kunii M, Saito A, Arita Y, Koike H, Higuchi O, Maeda Y, Abiru N, Yamaguchi N, Kawano H, Tsuiki E, Tanaka T, Matsuo H, Katsuno M, Tanaka F, Tsujino A, Nakane S. Association between neurosarcoidosis with autonomic dysfunction and anti-ganglionic acetylcholine receptor antibodies. J Neurol. 268: 4265-4279, 2021
  38. Riku Y, Yoshida M, Tamura T, Kamijo M, Yasui K, Kameyama T, Katsuno M, Sobue G, Iwasaki Y. Unexpected postmortem diagnoses in cases of clinically diagnosed amyotrophic lateral sclerosis. Neuropathology. 41: 457-467, 202
  39. Tanaka Y, Tsuboi T, Watanabe H, Torii J, Nakatsubo D, Maesawa S, Sato M, Hiraga K, Satake Y, Yokoi K, Hattori M, Kawabata K, Hara K, Yamamoto M, Sobue G, Katsuno M. Instability of speech in Parkinson disease patients with subthalamic nucleus deep brain stimulation. Parkinsonism Relat Disord. 93: 8-11, 2021
  40. Noda S, Murakami A, Kimura S, Minamiyama M, Katsuno M, Kuru S. Duchenne Muscular Dystrophy Successfully Treated with Aripiprazole in a Patient with Autism Spectrum Disorder Symptoms Including Irritability. Intern Med. 60: 3983-3986, 2021
  41. Koike H, Chiba A, Katsuno M. Emerging Infection, Vaccination, and Guillain-Barré Syndrome: A Review. Neurol Ther. 10: 523-537, 2021
  42. Koike H, Okumura T, Murohara T, Katsuno M. Multidisciplinary Approaches for Transthyretin Amyloidosis. Cardiol Ther. 10: 289-311, 2021
  43. Kato S, Bagarinao E, Isoda H, Koyama S, Watanabe H, Maesawa S, Mori D, Hara K, Katsuno M, Hoshiyama M, Naganawa S, Ozaki N, Sobue G. Effects of Head Motion on the Evaluation of Age-related Brain Network Changes Using Resting State Functional MRI. Magn Reson Med Sci. 20: 338-346, 2021
2020
  1. Kawabata K, Ohdake R, Watanabe H, Bagarinao E, Hara K, Ogura A, Masuda M, Kato T, Yokoi T, Katsuno M, Sobue G. Visuoperceptual disturbances in Parkinson's disease. Clin Parkinism Relat Disord. 3: 100036, 2020
  2. Chiu SY, Tsuboi T, Hegland KW, Herndon NE, Shukla AW, Patterson A, Almeida L, Foote KD, Okun MS, Ramirez-Zamora A. Dysarthria and Speech Intelligibility Following Parkinson's Disease Globus Pallidus Internus Deep Brain Stimulation. J Parkinsons Dis. 10: 1493-1502, 2020
  3. Mei S, Eisinger RS, Hu W, Tsuboi T, Foote KD, Hass CJ, Okun MS, Chan P, Ramirez-Zamora A. Three-Year Gait and Axial Outcomes of Bilateral STN and GPi Parkinson's Disease Deep Brain Stimulation. Front Hum Neurosci. 14: 1, 2020
  4. Okromelidze L, Tsuboi T, Eisinger RS, Burns MR, Charbel M, Rana M, Grewal SS, Lu CQ, Almeida L, Foote KD, Okun MS, Middlebrooks EH. Functional and Structural Connectivity Patterns Associated with Clinical Outcomes in Deep Brain Stimulation of the Globus Pallidus Internus for Generalized Dystonia. AJNR Am J Neuroradiol. 41: 508-514, 2020
  5. Tsuboi T, Jabarkheel Z, Zeilman PR, Barabas MJ, Foote KD, Okun MS, Wagle Shukla A. Longitudinal follow-up with VIM thalamic deep brain stimulation for dystonic or essential tremor. Neurology. 94: e1073-e1084, 2020
  6. Tsuboi T, Wong JK, Almeida L, Hess CW, Wagle Shukla A, Foote KD, Okun MS, Ramirez-Zamora A. A pooled meta-analysis of GPi and STN deep brain stimulation outcomes for cervical dystonia. J Neurol. 267: 1278-1290, 2020
  7. Ramirez-Zamora A, Tsuboi T. Hospital Management of Parkinson Disease Patients. Clin Geriatr Med. 36: 173-181, 2020
  8. Watanabe Y, Raaphorst J, Izumi Y, Yoshino H, Ito S, Adachi T, Takigawa H, Masuda M, Atsuta N, Adachi Y, Isose S, Arai K, Yokota O, Oda M, Ogino M, Ichikawa H, Hasegawa K, Kimura H, Shimizu T, Aiba I, Yabe H, Kanba M, Kusumi K, Aoki T, Hiroe Y, Watanabe H, Nishiyama K, Nomoto M, Sobue G, Beeldman E, Hanajima R, Nakashima K; ALS-FTD-Q-J research group. Cognitive and behavioral status in Japanese ALS patients: a multicenter study. J Neurol. 267: 1321-1330, 2020
  9. Ueyama J, Oda M, Hirayama M, Sugitate K, Sakui N, Hamada R, Ito M, Saito I, Ohno K. Freeze-drying enables homogeneous and stable sample preparation for determination of fecal short-chain fatty acids. Analytical Biochemistry. 589: 113508, 2020
  10. Ueda M, Nakamura T, Suzuki M, Imai E, Harada Y, Hara K, Hirayama M, Katsuno M. Association of orthostatic blood pressure with the symptoms of orthostatic hypotension and cognitive impairment in patients with multiple system atrophy. J Clin Neurosci. 75: 40-44, 2020.
  11. Nishi R, Koike H, Ohyama K, Fukami Y, Ikeda S, Kawagashira Y, Iijima M, Katsuno M, Sobue G. Differential clinicopathologic features of EGPA-associated neuropathy with and without ANCA. Neurology. 94: e1726-e1737, 2020
  12. Nakamura T, Suzuki M, Ueda M, Harada Y, Hirayama M, Katsuno M. Impact of orthostatic hypotension on wheelchair use in patients with Parkinson's disease. J Neural Transm (Vienna). 127: 379-383, 2020
  13. Tsuboi T, Harada Y, Suzuki M, Ando T, Atsuta N, Ohka F, Takeuchi K, Taoka T, Ohba S, Nakaguro M, Abe M, Nakashima I, Yoshida M, Katsuno M. Steroid-responsive recurrent tumefactive demyelination with multiple petechial hemorrhages along non-displaced medullary veins. Clin Neurol Neurosurg. 193: 105764, 2020
  14. Suzuki M, Nakamura T, Hirayama M, Ueda M, Imai E, Harada Y, Katsuno M. Relationship between cardiac parasympathetic dysfunction and the anteroposterior diameter of the medulla oblongata in multiple system atrophy. Clin Auton Res. 30: 231-238, 2020
  15. Onodera K, Shimojo D, Ishihara Y, Yano M, Miya F, Banno H, Kuzumaki N, Ito T, Okada R, de Araújo Herculano B, Ohyama M, Yoshida M, Tsunoda T, Katsuno M, Doyu M, Sobue G, Okano H, Okada Y. Unveiling synapse pathology in spinal bulbar muscular atrophy by genome-wide transcriptome analysis of purified motor neurons derived from disease specific iPSCs. Mol Brain. 13: 18, 2020
  16. Araki K, Nakamura T, Takeuchi Y, Morozumi S, Horie K, Kobayashi Y, Kawakami O, Sobue F, Ueda T, Hamada K, Ando T, Inoue Y, Yasui K, Morozumi K, Maruyama S, Katsuno M. Pharmacological monitoring of antiepileptic drugs in epilepsy patients on haemodialysis. Epileptic Disord. 22: 90-102, 2020
  17. Hattori M, Tsuboi T, Yokoi K, Tanaka Y, Sato M, Suzuki K, Arahata Y, Hori A, Kawashima M, Hirakawa A, Washimi Y, Watanabe H, Katsuno M. Subjects at risk of Parkinson's disease in health checkup examinees: cross-sectional analysis of baseline data of the NaT-PROBE study. J Neurol. 267: 1516-1526, 2020
  18. Tanaka H, Homma H, Fujita K, Kondo K, Yamada S, Jin X, Waragai M, Ohtomo G, Iwata A, Tagawa K, Atsuta N, Katsuno M, Tomita N, Furukawa K, Saito Y, Saito T, Ichise A, Shibata S, Arai H, Saido T, Sudol M, Muramatsu SI, Okano H, Mufson EJ, Sobue G, Murayama S, Okazawa H. YAP-dependent necrosis occurs in early stages of Alzheimer's disease and regulates mouse model pathology. Nat Commun. 11: 507, 2020
  19. Hayashi N, Atsuta N, Yokoi D, Nakamura R, Nakatochi M, Katsuno M, Izumi Y, Kanai K, Hattori N, Taniguchi A, Morita M, Kano O, Shibuya K, Kuwabara S, Suzuki N, Aoki M, Aiba I, Mizoguchi K, Oda M, Kaji R, Sobue G. Prognosis of amyotrophic lateral sclerosis patients undergoing tracheostomy invasive ventilation therapy in Japan. J Neurol Neurosurg Psychiatry. 91: 285-290, 2020
  20. Koike H, Katsuno M. Expanding the spectrum of transthyretin amyloidosis. Muscle Nerve. 61: 3-4, 2020
  21. Tanaka Y, Tsuboi T, Watanabe H, Nakatsubo D, Maesawa S, Kato S, Kajita Y, Sato M, Oodake R, Hattori M, Yamamoto M, Wakabayashi T, Katsuno M, Sobue G. Longitudinal Speech Change After Subthalamic Nucleus Deep Brain Stimulation in Parkinson's Disease Patients: A 2-Year Prospective Study. J Parkinsons Dis. 10: 131-140, 2020
  22. Sakakibara S, Hashimoto R, Katayama T, Kenjyo M, Yokokawa Y, Saito Y, Hirakawa A, Ito M, Nakamura T, Hara K, Hashizume A, Aiba I, Inukai A, Katsuno M. Longitudinal Change of DAT SPECT in Parkinson's Disease and Multiple System Atrophy. J Parkinsons Dis. 10 :123-130, 2020
  23. Koike H, Ikeda S, Fukami Y, Nishi R, Kawagashira Y, Iijima M, Nakamura T, Kuwahara M, Kusunoki S, Katsuno M, Sobue G. Complement deposition and macrophage-induced demyelination in CIDP with anti-LM1 antibodies. J Neurol Sci. 408: 116509, 2020
  24. Fukami Y, Koike H, Iijima M, Hagita J, Niwa H, Nishi R, Kawagashira Y, Katsuno M. Demyelinating Neuropathy Due to Intravascular Large B-cell Lymphoma. Intern Med. 59: 435-438, 2020
  25. Tsuboi T, Wong JK, Okun MS, Ramirez-Zamora A. Quality of life outcomes after deep brain stimulation in dystonia: A systematic review. Parkinsonism Relat Disord. 70: 82-93, 2020
2019
  1. Koike H, Katsuno M, Sobue G: New teased-fibre definitions represent specific mechanisms of neuropathy. J Neurol Neurosurg Psychiatry. 90: 124, 2019
  2. Ando T, Torii R, Kazuta T, Endo T, Araki A, Horiuchi T, Terao S, Katsuno M: Hereditary Angioedema Type 1 with Recurrent Dizziness. Intern Med. 58: 1961–1963, 2019
  3. Halievski K, Nath SR, Katsuno M, Adachi H, Sobue G, Breedlove SM, Lieberman AP, Jordan CL: Disease Affects BDNF Expression in Synaptic and Extrasynaptic Regions of Skeletal Muscle of Three SBMA Mouse Models. Int J Mol Sci. 20: 1314, 2019
  4. Ikenaka K, Atsuta N, Maeda Y, Hotta Y, Nakamura R, Kawai K, Yokoi D, Hirakawa A, Taniguchi A, Morita M, Mizoguchi K, Mochizuki H, Kimura K, Katsuno M, Sobue G: Increase of arginine dimethylation correlates with the progression and prognosis of ALS. Neurology. 92: e1868–e1877, 2019
  5. Seki M, Uruha A, Ohnuki Y, Kamada S, Noda T, Onda A, Ohira M, Isami A, Hiramatsu S, Hibino M, Nakane S, Noda S, Yutani S, Hanazono A, Yaguchi H, Takao M, Shiina T, Katsuno M, Nakahara J, Matsubara S, Nishino I, Suzuki S: Inflammatory myopathy associated with PD-1 inhibitors. J Autoimmun. 100: 105–113, 2019
  6. Hashizume A, Katsuno M, Suzuki K, Banno H, Takeuchi Y, Kawashima M, Suga N, Mano T, Araki A, Hijikata Y, Hirakawa A, Sobue G; JASMITT study group: Efficacy and safety of leuprorelin acetate for subjects with spinal and bulbar muscular atrophy: pooled analyses of two randomized-controlled trials. J Neurol. 266: 1211–1221, 2019
  7. Ando T, Iijima M, Fukami Y, Nishi R, Ikeda S, Yokoi S, Kawagashira Y, Koike H, Muro Y, Katsuno M: Vasculitic neuropathy with anti-phosphatidylserine/prothrombin complex antibody. Muscle Nerve. 59: E44–E46, 2019
  8. Koike H, Katsuno M: Ultrastructure in Transthyretin Amyloidosis: From Pathophysiology to Therapeutic Insights. Biomedicines. 7: 11, 2019
  9. Senda J, Araki K, Tachi Y, Watanabe H, Kawagashira Y, Ito M, Atsuta N, Katsuno M, Watanabe H, Sobue G: Acute Unilateral Isolated Oculomotor Nerve Palsy in an Adult Patient with Influenza A. Intern Med. 58: 433–436, 2019
  10. Iwase T, Yoshida M, Hashizume Y, Yazawa I, Takahashi S, Ando T, Ikeda T, Nokura K: Intracranial vascular calcification with extensive white matter changes in an autopsy case of pseudopseudohypoparathyroidism. Neuropathology. 39: 39–46, 2019
  11. Yoritaka A, Ohtsuka C, Maeda T, Hirayama M, Abe T, Watanabe H, Saiki H, Oyama G, Fukae J, Shimo Y, Hatano T, Kawajiri S, Okuma Y, Machida Y, Miwa H, Suzuki C, Kazama A, Tomiyama M, Kihara T, Hirasawa M, Shimura H, Oda E, Ito M, Ohno K, Hattori N: Randomized, double-blind, multicenter trial of hydrogen water for Parkinson’s disease. Mov Disord. 33: 1505–1507, 2018
  12. Hirayama M, Ito M, Minato T, Yoritaka A, LeBaron TW, Ohno K: Inhalation of hydrogen gas elevates urinary 8-hydroxy-2’-deoxyguanine in Parkinson’s disease. Med Gas Res. 8: 144–149, 2019
  13. Sato T, Terasawa Y, Higa H, Matsuno H, Arai A, Omoto S, Mitsumura H, Toyoda C, Koike H, Iguchi Y: Nerve Ultrasound, Electrophysiological, and Clinical Changes in Treatment-Naïve Chronic Inflammatory Demyelinating Polyneuropathy: A Case Report. J Clin Neurophysiol. 36: 82–84, 2019
  14. Mori-Yoshimura M, Yamashita S, Suzuki N, Katsuno M, Murata K, Nodera H, Teshima R, Inamura T, Nishino I, Aoki M. Late phase II/III study of BYM338 in patients with sporadic inclusion body myositis (RESILIENT): Japanese cohort data. Rinsho Shinkeigaku. 59: 806-813, 2019
  15. Atsuta N, Nakamura R, Hayashi N, Tohnai G, Katsuno M, Sobue G. The Role of Patient Registry in the Care and Therapeutic Development for Patients with Amyotrophic Lateral Sclerosis: JaCALS. Brain Nerve. 71: 1215-1225, 2019
  16. Tanaka S, Hashizume A, Hijikata Y, Yamada S, Ito D, Nakayama A, Kurita K, Yogo H, Banno H, Suzuki K, Yamamoto M, Sobue G, Katsuno M. Nasometric Scores in spinal and bulbar muscular atrophy - Effects of palatal lift prosthesis on dysarthria and dysphagia. J Neurol Sci. 407: 116503, 2019
  17. Senda J, Ito K, Kotake T, Kanamori M, Kishimoto H, Kadono I, Nakagawa-Senda H, Wakai K, Katsuno M, Nishida Y, Ishiguro N, Sobue G. Cilostazol use is associated with FIM cognitive improvement during convalescent rehabilitation in patients with ischemic stroke: a retrospective study. Nagoya J Med Sci. 81: 359-373, 2019
  18. Kano Y, Kato H, Koike H, Katsuno M, Oguri T, Yuasa H. Multiple mononeuropathy associated with systemic sclerosis with vasculitis confirmed by nerve biopsy: a case report. Rinsho Shinkeigaku. 59: 604-606, 2019
  19. Mizuno Y, Shinoda K, Watanabe M, Ogata H, Isobe N, Matsushita T, Yamasaki R, Tanaka K, Koike H, Katsuno M, Kira JI. Intractable axonal neuropathy with multifocal peripheral nerve swelling in neuromyelitis optica spectrum disorders: A case report. Mult Scler Relat Disord. 35: 16-18, 2019
  20. Iida M, Sahashi K, Kondo N, Nakatsuji H, Tohnai G, Tsutsumi Y, Noda S, Murakami A, Onodera K, Okada Y, Nakatochi M, Tsukagoshi Okabe Y, Shimizu S, Mizuno M, Adachi H, Okano H, Sobue G, Katsuno M. Src inhibition attenuates polyglutamine-mediated neuromuscular degeneration in spinal and bulbar muscular atrophy. Nat Commun. 10: 4262, 2019
  21. Sekine SI, Kaneko M, Tanaka M, Ninomiya Y, Kurita H, Inden M, Yamada M, Hayashi Y, Inuzuka T, Mitsui J, Ishiura H, Iwata A, Fujigasaki H, Tamaki H, Tamaki R, Kito S, Taguchi Y, Tanaka K, Atsuta N, Sobue G, Kondo T, Inoue H, Tsuji S, Hozumi I. Functional evaluation of PDGFB-variants in idiopathic basal ganglia calcification, using patient-derived iPS cells. Sci Rep. 9: 5698, 2019
  22. Ogura A, Watanabe H, Kawabata K, Ohdake R, Tanaka Y, Masuda M, Kato T, Imai K, Yokoi T, Hara K, Bagarinao E, Riku Y, Nakamura R, Kawai Y, Nakatochi M, Atsuta N, Katsuno M, Sobue G. Semantic deficits in ALS related to right lingual/fusiform gyrus network involvement. EBioMedicine. 47: 506-517,2019
  23. Ito D, Hashizume A, Hijikata Y, Yamada S, Iguchi Y, Iida M, Kishimoto Y, Moriyoshi H, Hirakawa A, Katsuno M. Elevated serum creatine kinase in the early stage of sporadic amyotrophic lateral sclerosis. J Neurol. 266: 2952-2961, 2019
  24. Hanna MG, Badrising UA, Benveniste O, Lloyd TE, Needham M, Chinoy H, Aoki M, Machado PM, Liang C, Reardon KA, de Visser M, Ascherman DP, Barohn RJ, Dimachkie MM, Miller JAL, Kissel JT, Oskarsson B, Joyce NC, Van den Bergh P, Baets J, De Bleecker JL, Karam C, David WS, Mirabella M, Nations SP, Jung HH, Pegoraro E, Maggi L, Rodolico C, Filosto M, Shaibani AI, Sivakumar K, Goyal NA, Mori-Yoshimura M, Yamashita S, Suzuki N, Katsuno M, Murata K, Nodera H, Nishino I, Romano CD, Williams VSL, Vissing J, Auberson LZ, Wu M, de Vera A, Papanicolaou DA, Amato AA; RESILIENT Study Group. Safety and efficacy of intravenous bimagrumab in inclusion body myositis (RESILIENT): a randomised, double-blind, placebo-controlled phase 2b trial. Lancet Neurol. 18: 834-844, 2019
  25. Koike H, Nishi R, Ikeda S, Kawagashira Y, Iijima M, Katsuno M, Sobue G. Evolution of amyloid fibrils in hereditary transthyretin amyloidosis: an ultrastructural study. Amyloid. 26: 6, 2019
  26. Ikenaka K, Tsukada Y, Giles AC, Arai T, Nakadera Y, Nakano S, Kawai K, Mochizuki H, Katsuno M, Sobue G, Mori I. A behavior-based drug screening system using a Caenorhabditis elegans model of motor neuron disease. Sci Rep. 9: 10104, 2019
  27. Araki K, Araki A, Honda D, Izumoto T, Hashizume A, Hijikata Y, Yamada S, Iguchi Y, Hara A, Ikumi K, Kawai K, Ishigaki S, Nakamichi Y, Tsunekawa S, Seino Y, Yamamoto A, Takayama Y, Hidaka S, Tominaga M, Ohara-Imaizumi M, Suzuki A, Ishiguro H, Enomoto A, Yoshida M, Arima H, Muramatsu SI, Sobue G, Katsuno M. TDP-43 regulates early-phase insulin secretion via CaV1.2-mediated exocytosis in islets. J Clin Invest. 129: 3578-3593, 2019
  28. Sone J, Mitsuhashi S, Fujita A, Mizuguchi T, Hamanaka K, Mori K, Koike H, Hashiguchi A, Takashima H, Sugiyama H, Kohno Y, Takiyama Y, Maeda K, Doi H, Koyano S, Takeuchi H, Kawamoto M, Kohara N, Ando T, Ieda T, Kita Y, Kokubun N, Tsuboi Y, Katoh K, Kino Y, Katsuno M, Iwasaki Y, Yoshida M, Tanaka F, Suzuki IK, Frith MC, Matsumoto N, Sobue G. Long-read sequencing identifies GGC repeat expansions in NOTCH2NLC associated with neuronal intranuclear inclusion disease. Nat Genet. 51: 1215-1221, 2019
  29. Bagarinao E, Watanabe H, Maesawa S, Mori D, Hara K, Kawabata K, Yoneyama N, Ohdake R, Imai K, Masuda M, Yokoi T, Ogura A, Taoka T, Koyama S, Tanabe HC, Katsuno M, Wakabayashi T, Kuzuya M, Ozaki N, Hoshiyama M, Isoda H, Naganawa S, Sobue G. Reorganization of brain networks and its association with general cognitive performance over the adult lifespan. Sci Rep. 9: 11352, 2019
  30. Hijikata Y, Hashizume A, Yamada S, Ito D, Banno H, Suzuki K, Sobue G, Katsuno M. Long-term Effects of Androgen Deprivation in a Patient with Spinal and Bulbar Muscular Atrophy - A Case Report with 14 Years of Follow-up. Intern Med. 58: 2231-2234, 2019
  31. Ikeda S, Koike H, Nishi R, Kawagashira Y, Iijima M, Katsuno M, Sobue G. Clinicopathological characteristics of subtypes of chronic inflammatory demyelinating polyradiculoneuropathy. J Neurol Neurosurg Psychiatry. 90: 988-996, 2019
  32. Riku Y, Duyckaerts C, Boluda S, Plu I, Le Ber I, Millecamps S, Salachas F; Brainbank NeuroCEB Neuropathology Network, Yoshida M, Ando T, Katsuno M, Sobue G, Seilhean D. Increased prevalence of granulovacuolar degeneration in C9orf72 mutation. Acta Neuropathol. 138: 783-793, 2019
  33. Kawabata K, Hara K, Watanabe H, Bagarinao E, Ogura A, Masuda M, Yokoi T, Kato T, Ohdake R, Ito M, Katsuno M, Sobue G. Alterations in Cognition-Related Cerebello-Cerebral Networks in Multiple System Atrophy. Cerebellum. 18: 770-780, 2019
  34. Tsuboi T, Watanabe H, Tanaka Y, Ohdake R, Sato M, Hattori M, Kawabata K, Hara K, Nakatsubo D, Maesawa S, Kajita Y, Katsuno M, Sobue G. Clinical correlates of repetitive speech disorders in Parkinson's disease. J Neurol Sci. 401: 67-71, 2019
  35. Kondo N, Tohnai G, Sahashi K, Iida M, Kataoka M, Nakatsuji H, Tsutsumi Y, Hashizume A, Adachi H, Koike H, Shinjo K, Kondo Y, Sobue G, Katsuno M. DNA methylation inhibitor attenuates polyglutamine-induced neurodegeneration by regulating Hes5. EMBO Mol Med. 11: e8547, 2019
  36. Koike H, Nakamura T, Nishi R, Ikeda S, Kawagashira Y, Iijima M, Katsuno M, Sobue G. Cardiac and peripheral vasomotor autonomic functions in hereditary transthyretin amyloidosis with non-Val30Met mutation. Amyloid. 26: 13-14, 2019
  37. Koike H, Nakamura T, Nishi R, Ikeda S, Kawagashira Y, Iijima M, Yasuda T, Mukai E, Date Y, Shiomi K, Nakazato M, Katsuno M, Sobue G. Common clinicopathological features in late-onset hereditary transthyretin amyloidosis (Ala97Gly, Val94Gly, and Val30Met). Amyloid. 26: 24-25, 2019
  38. Yamada S, Yasui K, Kawakami Y, Hasegawa Y, Katsuno M. DEFENSIVE Stroke Scale: Novel Diagnostic Tool for Predicting Posterior Circulation Infarction in the Emergency Department. J Stroke Cerebrovasc Dis. 28: 1561-1570, 2019
  39. Adams D, Koike H, Slama M, Coelho T. Hereditary transthyretin amyloidosis: a model of medical progress for a fatal disease. Nat Rev Neurol. 15 :387-404, 2019
  40. Nakamura T, Koike H, Nishi R, Ikeda S, Kawagashira Y, Iijima M, Katsuno M, Sobue G. Cardiovascular autonomic functions in late-onset hereditary transthyretin amyloidosis with Val30Met mutation. Amyloid. 26:6, 2019
  41. Fujishiro H, Kimura H, Nakamura T, Torii Y, Iritani S, Ozaki N. Hypochondriasis in the elderly and Lewy body disease. Psychogeriatrics. 19: 516-518, 2019
  42. Tsuboi T, Watanabe H, Katsuno M, Sobue G. Pergolide in the Treatment of Parkinson’s Disease. In: Riederer P, Laux G, Mulsant B, Le W, Nagatsu T. (eds) NeuroPsychopharmacotherapy, 2019
  43. Tsuboi T, Watanabe H, Katsuno M, Sobue G. Cabergoline in the Treatment of Parkinson’s Disease. In: Riederer P, Laux G, Mulsant B, Le W, Nagatsu T. (eds) NeuroPsychopharmacotherapy, 2019
  44. Sharma G, Huo A, Kimura T, Shiozawa S, Kobayashi R, Sahara N, Ishibashi M, Ishigaki S, Saito T, Ando K, Murayama S, Hasegawa M, Sobue G, Okano H, Hisanaga SI. Tau isoform expression and phosphorylation in marmoset brains. J Biol Chem. 294, 11433-11444,2019
  45. Abe, K. Hirayama, M. Ohno, K. Shimamura, T. ENIGMA: an enterotype-like unigram mixture model for microbial association analysis. BMC Genomics. 20: 191, 2019
2018
  1. Tohnai G, Nakamura R, Sone J, Nakatochi M, Yokoi D, Katsuno M, Watanabe H, Ito M, Li Y, Izumi Y, Morita M, Taniguchi A, Kano O, Oda M, Kuwabara S, Abe K, Aiba I, Okamoto K, Mizoguchi K, Hasegawa K, Aoki M, Hattori N, Onodera O, Naruse H, Mitsui J, Takahashi Y, Goto J, Ishiura H, Morishita S, Yoshimura J, Doi K, Tsuji S, Nakashima K, Kaji R, Atsuta N, Sobue G; Japanese Consortium for Amyotrophic Lateral Sclerosis Research (JaCALS): Frequency and characteristics of the TBK1 gene variants in Japanese patients with sporadic amyotrophic lateral sclerosis. Neurobiol Aging. 64: 158.e15–158.e19, 2018
  2. Yoneyama N, Watanabe H, Kawabata K, Bagarinao E, Hara K, Tsuboi T, Tanaka Y, Ohdake R, Imai K, Masuda M, Hattori T, Ito M, Atsuta N, Nakamura T, Hirayama M, Maesawa S, Katsuno M, Sobue G: Severe hyposmia and aberrant functional connectivity in cognitively normal Parkinson’s disease. PLoS One. 13: e0190072, 2018
  3. Ninomiya H, Ohgami N, Oshino R, Kato M, Ohgami K, Li X, Shen D, Iida M, Yajima I, Angelidis CE, Adachi H, Katsuno M, Sobue G, Kato M: Increased expression level of Hsp70 in the inner ears of mice by exposure to low frequency noise. Hear Res. 363: 49–54, 2018
  4. Koike H, Nishi R, Ikeda S, Kawagashira Y, Iijima M, Atsuta N, Nakamura T, Hirayama M, Ogata H, Yamasaki R, Kira JI, Katsuno M, Sobue G: Restoration of a Conduction Block after the Long-term Treatment of CIDP with Anti-neurofascin 155 Antibodies: Follow-up of a Case over 23 Years. Intern Med. 57: 2061–2066, 2018
  5. Tanikawa C, Ueda K, Suzuki A, Iida A, Nakamura R, Atsuta N, Tohnai G, Sobue G, Saichi N, Momozawa Y, Kamatani Y, Kubo M, Yamamoto K, Nakamura Y, Matsuda K: Citrullination of RGG Motifs in FET Proteins by PAD4 Regulates Protein Aggregation and ALS Susceptibility. Cell Rep. 22: 1473–1483, 2018
  6. Sekijima Y, Yazaki M, Ueda M, Koike H, Yamada M, Ando Y: First nationwide survey on systemic wild-type ATTR amyloidosis in Japan. Amyloid. 25: 8–10, 2018
  7. Hijikata Y, Katsuno M, Suzuki K, Hashizume A, Araki A,Yamada S, Inagaki T, Ito D, Hirakawa A, Kinoshita F, Gosho M, Sobue G: Treatment with Creatine Monohydrate in Spinal and Bulbar Muscular Atrophy: Protocol for a Randomized, Double-Blind, Placebo-Controlled Trial. JMIR Res Protoc. 7: e69, 2018
  8. Hijikata Y, Hashizume A,Yamada S, Inagaki T, Ito D, Hirakawa A, Suzuki K, Atsuta N,Tsuboi T, Hattori M, Hori A, Banno H, Sobue G, Katsuno M: Biomarker-based analysis of preclinical progression in spinal and bulbar muscular atrophy. Neurology. 90: e1501–e1509, 2018
  9. Kawabata K, Watanabe H, Hara K, Bagarinao E, Yoneyama N, Ogura A, Imai K, Masuda M, Yokoi T, Ohdake R, Tanaka Y,Tsuboi T, Nakamura T, Hirayama M, Ito M, Atsuta N, Maesawa S, Naganawa S, Katsuno M, Sobue G: Distinct manifestation of cognitive deficits associate with different resting-state network disruptions in non-demented patients with Parkinson’s disease. J Neurol. 265: 688–700, 2018
  10. Koike H, Katsuno M, Sobue G: Deciphering mechanism and spectrum of chronic inflammatory demyelinating polyneuropathy by morphology. Clin Exp Neuroimmunol. 9: 35–46, 2018
  11. Ikumi K, Tsuboi T, Atsuta N, Takeuchi K, Koike H, Katsuno M: Long-standing overt ventriculomegaly without aqueductal stenosis: A case report. Neurol Clin Neurosci. 6: 42–44, 2018
  12. Tsuboi T, Watanabe H, Funasaka K, Takebayashi M, Miyata K and Katsuno M: Peritonitis after percutaneous endoscopic gastrojejunostomy for levodopa-carbidopa intestinal gel treatment despite concomitant use of gastropexy. Neurol Clin Neurosci. 6: 64–66, 2018
  13. Bagarinao E, Watanabe H, Maesawa S, et al.: An unbiased data-driven age-related structural brain parcellation for the identification of intrinsic brain volume changes over the adult lifespan. Neuroimage. 169: 134–144, 2018
  14. Sakamoto Y, Okamoto S, Maesawa S, Bagarinao E, Araki Y, Izumi T, Watanabe H, Sobue G, Wakabayashi T: Default Mode Network Changes in Moyamoya Disease Before and After Bypass Surgery: Preliminary Report. World Neurosurg. 112: e652–e661, 2018
  15. Koike H, Nishi R, Ikeda S, Kawagashira Y, Iijima M, Katsuno M, Sobue G: Ultrastructural mechanisms of macrophage-induced demyelination in CIDP. Neurology. 91: 1051–1060, 2018
  16. Masuda M, Watanabe H, Tanaka Y, Ohdake R, Ogura A, Yokoi T, Imai K, Kawabata K, Riku Y, Hara K, Nakamura R, Atsuta N, Katsuno M, Sobue G: Age-related impairment in Addenbrooke’s cognitive examination revised scores in patients with amyotrophic lateral sclerosis. Amyotroph Lateral Scler Frontotemporal Degener. 19: 578–584, 2018
  17. Yokoi T, Watanabe H, Yamaguchi H, Bagarinao E, Masuda M, Imai K, Ogura A, Ohdake R, Kawabata K, Hara K, Riku Y, Ishigaki S, Katsuno M , Miyao S, Kato K, Naganawa S, HaradaR, Okamura N, Yanai K, Yoshida M, Sobue G: Involvement of the Precuneus/Posterior Cingulate Cortex Is Significant for the Development of Alzheimer’s Disease: A PET (THK5351, PiB) and Resting fMRI Study. Front Aging Neurosci. 10: 304, 2018
  18. Hashizume A, Katsuno M: IGF-1 for spinal and bulbar muscular atrophy: hope and challenges. Lancet Neurol. 17: 1026–1027, 2018
  19. Koike H, Nishi R, Ikeda S, Kawagashira Y, Iijima M, Sakurai T, Shimohata T, Katsuno M, Sobue G: The morphology of amyloid fibrils and their impact on tissue damage in hereditary transthyretin amyloidosis: An ultrastructural study. J Neurol Sci. 394: 99–106, 2018
  20. Katsuno M, Sahashi K, Iguchi Y, Hashizume A: Preclinical progression of neurodegenerative diseases. Nagoya J Med Sci. 80: 289–298, 2018
  21. Yamada S, Hashizume A, Hijikata Y, Inagaki T, Ito D, Kinoshita F, Nakatochi M, Kobayashi Y, Hirakawa A, Nakamura T, Katsuno M: Study protocol for the MEXiletine hydrochloride administration trial: a placebocontrolled, randomised, double-blind, multicentre, crossover study of its efficacy and safety in spinal and bulbar muscular atrophy (MEXPRESS). BMJ Open. 8: e023041, 2018
  22. Watanabe H, Riku Y, Hara K, Kawabata K, Nakamura T, Ito M, Hirayama M, Yoshida M, Katsuno M, Sobue G: Clinical and Imaging Features of Multiple System Atrophy: Challenges for an Early and Clinically Definitive Diagnosis. J Mov Disord. 11: 107–120, 2018
  23. Koike H, Nakamura T, Nishi R, Ikeda S, Kawagashira Y, Iijima M, Katsuno M, Sobue G: Widespread Cardiac and Vasomotor Autonomic Dysfunction in Non-Val30MetHereditary Transthyretin Amyloidosis. Intern Med. 57: 3365–3370, 2018
  24. Hara K, Watanabe H, Bagarinao E, Kawabata K, Yoneyama N, Ohdake R, Imai K, Masuda M, Yokoi T, Ogura A, Tsuboi T, Ito M, Atsuta N, Niwa H, Taoka T, Maesawa S, Naganawa S, Katsuno M, Sobue G: Corpus callosal involvement is correlated with cognitive impairment in multiple system atrophy. J Neurol. 265: 2079–2087, 2018
  25. Xu Y, Halievski K, Katsuno M, Adachi H, Sobue G, Breedlove SM, Jordan CL: Pre-clinical symptoms of SBMA may not be androgen-dependent: implications from two SBMA mouse models. Hum Mol Genet. 27: 2425–2442, 2018
  26. Koike H, Yasuda T, Nishi R, Ikeda S, Kawagashira Y, Iijima M, Sobue G, Katsuno M: Systemic angiopathy and axonopathy in hereditary transthyretin amyloidosis with Ala97Gly (p. Ala117Gly) mutation: a post-mortem analysis. Amyloid. 25: 141–142, 2018
  27. Ando T, Goto Y, Mano K, Nomura F, Kurashige M, Ito M, Mimuro M, Iwasaki Y, Katsuno M, Yoshida M: Paraneoplastic autoimmune encephalitis associated with pleomorphic lung carcinoma: An autopsy case report. Neuropathology. 2018 May 20
  28. Hijikata Y, Hashizume A, Yamada S, Inagaki T, Ito D, Hirakawa A, Suzuki K, Atsuta N, Tsuboi T, Hattori M, Hori A, Banno H, Sobue G, Katsuno M: Biomarker-based analysis of preclinical progression in spinal and bulbar muscular atrophy. Neurology. 90: e1501–e1509, 2018
  29. Ninomiya H, Ohgami N, Oshino R, Kato M, Ohgami K, Li X, Shen D, Iida M, Yajima I, Angelidis CE, Adachi H, Katsuno M, Sobue G, Kato M: Increased expression level of Hsp70 in the inner ears of mice by exposure to low frequency noise. Hear Res. 363: 49–54, 2018
  30. Koike H, Nishi R, Ikeda S, Kawagashira Y, Iijima M, Atsuta N, Nakamura T, Hirayama M, Ogata H, Yamasaki R, Kira JI, Katsuno M, Sobue G: Restoration of a Conduction Block after the Long-term Treatment of CIDP with Anti-neurofascin 155 Antibodies: Follow-up of a Case over 23 Years. Intern Med. 57: 2061–2066, 2018
  31. Tohnai G, Nakamura R, Sone J, Nakatochi M, Yokoi D, Katsuno M, Watanabe H, Ito M, Li Y, Izumi Y, Morita M, Taniguchi A, Kano O, Oda M, Kuwabara S, Abe K, Aiba I, Okamoto K, Mizoguchi K, Hasegawa K, Aoki M, Hattori N, Onodera O, Naruse H, Mitsui J, Takahashi Y, Goto J, Ishiura H, Morishita S, Yoshimura J, Doi K, Tsuji S, Nakashima K, Kaji R, Atsuta N, Sobue G; Japanese Consortium for Amyotrophic Lateral Sclerosis Research (JaCALS): Frequency and characteristics of the TBK1 gene variants in Japanese patients with sporadic amyotrophic lateral sclerosis. Neurobiol Aging. 64: 158.e15–158.e19, 2018
  32. Kawabata K, Watanabe H, Hara K, Bagarinao E, Yoneyama N, Ogura A, Imai K, Masuda M, Yokoi T, Ohdake R, Tanaka Y, Tsuboi T, Nakamura T, Hirayama M, Ito M, Atsuta N, Maesawa S, Naganawa S, Katsuno M, Sobue G: Distinct manifestation of cognitive deficits associate with different resting-state network disruptions in non-demented patients with Parkinson’s disease. J Neurol. 265: 688–700, 2018
  33. Endo K, Ishigaki S, Masamizu Y, Fujioka Y, Watakabe A, Yamamori T, Hatanaka N, Nambu A, Okado H, Katsuno M, Watanabe H, Matsuzaki M, Sobue G: Silencing of FUS in the common marmoset (Callithrix jacchus) brain via stereotaxic injection of an adeno-associated virus encoding shRNA. Neurosci Res. 130: 56–64, 2018
  34. Suzuki A, Ito M, Hamaguchi T, Mori H, Takeda Y, Baba R, Watanabe T, Kurokawa K, Asakawa S, Hirayama M, Ohno K: Quantification of hydrogen production by intestinal bacteria that are specifically dysregulated in Parkinson’s disease. PLoS One. 13: e0208313, 2018
  35. Abe K, Hirayama M, Ohno K, Shimamura T: A latent allocation model for the analysis of microbial composition and disease. BMC Bioinformatics. 19: 519, 2018
  36. Misawa S, Kuwabara S, Sato Y, Yamaguchi N, Nagashima K, Katayama K, Sekiguchi Y, Iwai Y, Amino H, Suichi T, Yokota T, Nishida Y, Kanouchi T, Kohara N, Kawamoto M, Ishii J, Kuwahara M, Suzuki H, Hirata K, Kokubun N, Masuda R, Kaneko J, Yabe I, Sasaki H, Kaida KI, Takazaki H, Suzuki N, Suzuki S, Nodera H, Matsui N, Tsuji S, Koike H, Yamasaki R, Kusunoki S; Japanese Eculizumab Trial for GBS (JET-GBS) Study Group: Safety and efficacy of eculizumab in Guillain-Barré syndrome: a multicentre, doubleblind, randomised phase 2 trial. Lancet Neurol. 17: 519–529, 2018
  37. Watanabe E, Fujita T, Shimono M, Koike H, Yasumoto S, Hirose S: Recurrent autonomic and sensory neuropathy in a patient with anti-ganglionic acetylcholine receptor antibodies. eNeurologicalSci. 12: 36–38, 2018
  38. Sekijima Y, Yazaki M, Ueda M, Koike H, Yamada M, Ando Y: First nationwide survey on systemic wild-type ATTR amyloidosis in Japan. Amyloid. 25: 8–10, 2018
  39. Fujimori K, Ishikawa M, Otomo A, Atsuta N, Nakamura R, Akiyama T, Hadano S, Aoki M, Saya H, Sobue G, Okano H: Modeling sporadic ALS in iPSC-derived motor neurons identifies a potential therapeutic agen.t Nat Med. 24: 1579–1589, 2018
  40. Sobue G, Ishigaki S, Watanabe H: Pathogenesis of Frontotemporal Lobar Degeneration: Insights From Loss of Function Theory and Early Involvement of the Caudate Nucleus. Front Neurosci. 12: 473, 2018
  41. Ishigaki S, Sobue G: Importance of Functional Loss of FUS in FTLD/ALS. Front Mol Biosci. 5: 44, 2018
  42. Oki R, Izumi Y, Nodera H, Sato Y, Nokihara H, Kanai K, Sonoo M, Urushitani M, Nishinaka K, Atsuta N, Kohara N, Shimizu T, Kikuchi H, Oda M, Ikeda K, Nagai M, Komai K, Kojima Y, Kuzume D, Isose S, Shimohama S, Abe K, Ito H, Noda K, Ishihara T, Morita M, Shimohata T, Teramukai S, Kagimura T, Noma K, Yanagawa H, Kuwabara S, Kaji R; JETALS: The Japanese Early-Stage Trial of High-Dose Methylcobalamin for Amyotrophic Lateral Sclerosis (JETALS): Protocol for a Randomized Controlled Trial. JMIR Res Protoc. 7: e12046, 2018
  43. Sahashi K, Katsuno M: Pathogenesis of Polyglutamine Diseases eLS. John Wiley & Sons, Ltd: Chichester. Sinha R, Kim YJ, Nomakuchi T, Sahashi K, Hua Y, Rigo F, Bennett CF, Krainer AR: Antisense oligonucleotides correct the familial dysautonomia splicing defect in IKBKAP transgenic mice. Nucleic Acids Res. 46: 4833–4844, 2018
  44. Kuwabara S, Misawa S, Mori M, Iwai Y, Ochi K, Suzuki H, Nodera H, Tamaoka A, Iijima M, Toda T, Yoshikawa H, Kanda T, Sakamoto K, Kusunoki S, Sobue G, Kaji R; Glovenin-I MMN Study Group: Intravenous immunoglobulin for maintenance treatment of multifocal motor neuropathy: A multi-center, open-label, 52-week phase 3 trial. J Peripher Nerv Syst. 23: 115–119, 2018
  45. Iijima M: Animal models of chronic inflammatory demyelinating polyneuropathy. Clin Exp Neuroimmunol. 9: 101–109, 2018
2017
  1. Tsuboi T, Watanabe H, Tanaka Y, Ohdake R, Hattori M, Kawabata K, Hara K, Ito M, Fujimoto Y, Nakatsubo D, Maesawa S, Kajita Y, Katsuno M, Sobue G. Early detection of speech and voice disorders in Parkinson's disease patients treated with subthalamic nucleus deep brain stimulation: a 1-year follow-up study. J Neural Transm (Vienna). 2017 Dec;124(12):1547-1556.
  2. Takahashi M, Koike H, Ikeda S, Kawagashira Y, Iijima M, Hashizume A, Katsuno M, Sobue G. Distinct pathogenesis in nonsystemic vasculitic neuropathy and microscopic polyangiitis. Neurol Neuroimmunol Neuroinflamm. 2017 Oct 23;4(6):e407.
  3. Hashizume A, Banno H, Katsuno M, Hijikata Y, Yamada S, Inagaki T, Suzuki K, Sobue G. Quantitative Assessment of Swallowing Dysfunction in Patients with Spinal and Bulbar Muscular Atrophy. Intern Med. 2017 Dec 1;56(23):3159-3165.
  4. Koike H, Nakamura T, Hashizume A, Nishi R, Ikeda S, Kawagashira Y, Iijima M, Katsuno M, Sobue G. Cardiac and peripheral vasomotor autonomic functions in late-onset transthyretin Val30Met familial amyloid polyneuropathy. J Neurol. 2017 Nov;264(11):2293-2302.
  5. Yokoi S, Udagawa T, Fujioka Y, Honda D, Okado H, Watanabe H, Katsuno M, Ishigaki S, Sobue G. 3'UTR Length-Dependent Control of SynGAP Isoform α2 mRNA by FUS and ELAV-like Proteins Promotes Dendritic Spine Maturation and Cognitive Function. Cell Rep. 2017 Sep 26;20(13):3071-3084.
  6. Riku Y, Watanabe H, Mimuro M, Iwasaki Y, Ito M, Katsuno M, Sobue G, Yoshida M. Non-motor multiple system atrophy associated with sudden death: pathological observations of autonomic nuclei. J Neurol. 2017 Nov;264(11):2249-2257.
  7. Sone J, Nakamura T, Koike H, Katsuno M, Tanaka F, Iwasaki Y, Yoshida M, Sobue G. Reply: Neuronal intranuclear (hyaline) inclusion disease and fragile X-associated tremor/ataxia syndrome: a morphological and molecular dilemma. Brain. 2017 Aug 1;140(8):e52.
  8. Riku Y, Watanabe H, Yoshida M, Mimuro M, Iwasaki Y, Masuda M, Ishigaki S, Katsuno M, Sobue G. Pathologic Involvement of Glutamatergic Striatal Inputs From the Cortices in TAR DNA-Binding Protein 43 kDa-Related Frontotemporal Lobar Degeneration and Amyotrophic Lateral Sclerosis. J Neuropathol Exp Neurol. 2017 Sep 1;76(9):759-768.
  9. Endo K, Ishigaki S, Masamizu Y, Fujioka Y, Watakabe A, Yamamori T, Hatanaka N, Nambu A, Okado H, Katsuno M, Watanabe H, Matsuzaki M, Sobue G. Silencing of FUS in the common marmoset (Callithrix jacchus) brain via stereotaxic injection of an adeno-associated virus encoding shRNA. Neurosci Res. 2017 Aug 24. pii:S0168-0102(17)30183-9.
  10. Banno H, Katsuno M, Suzuki K, Tanaka S, Suga N, Hashizume A, Mano T, Araki A, Watanabe H, Fujimoto Y, Yamamoto M, Sobue G. Swallowing markers in spinal and bulbar muscular atrophy. Ann Clin Transl Neurol. 2017 May 24;4(8):534-543.
  11. Hashizume A, Katsuno M, Suzuki K, Hirakawa A, Hijikata Y, Yamada S, Inagaki T, Banno H, Sobue G. Long-term treatment with leuprorelin for spinal and bulbar muscular atrophy: natural history-controlled study. J Neurol Neurosurg Psychiatry. 2017 Dec;88(12):1026-1032.
  12. Kawagashira Y, Koike H, Kawabata K, Takahashi M, Ohyama K, Hashimoto R, Iijima M, Katsuno M, Sobue G. Vasculitic Neuropathy Following Exposure to a Glyphosate-based Herbicide. Intern Med. 2017;56(11):1431-1434.
  13. Senda J, Atsuta N, Watanabe H, Bagarinao E, Imai K, Yokoi D, Riku Y, Masuda M, Nakamura R, Watanabe H, Ito M, Katsuno M, Naganawa S, Sobue G. Structural MRI correlates of amyotrophic lateral sclerosis progression. J Neurol Neurosurg Psychiatry. 2017 Nov;88(11):901-907.
  14. Koike H, Ikeda S, Takahashi M, Kawagashira Y, Iijima M, Misumi Y, Ando Y, Ikeda SI, Katsuno M, Sobue G. Disruption of blood-nerve barriers in hereditary transthyretin (ATTR) amyloidosis. Amyloid. 2017 Mar;24(sup1):89-90.
  15. Nakatsuji H, Araki A, Hashizume A, Hijikata Y, Yamada S, Inagaki T, Suzuki K, Banno H, Suga N, Okada Y, Ohyama M, Nakagawa T, Kishida K, Funahashi T, Shimomura I, Okano H, Katsuno M, Sobue G. Correlation of insulin resistance and motor function in spinal and bulbar muscular atrophy. J Neurol. 2017 May;264(5):839-847.
  16. Ishigaki S, Fujioka Y, Okada Y, Riku Y, Udagawa T, Honda D, Yokoi S, Endo K, Ikenaka K, Takagi S, Iguchi Y, Sahara N, Takashima A, Okano H, Yoshida M, Warita H, Aoki M, Watanabe H, Okado H, Katsuno M, Sobue G. Altered Tau Isoform Ratio Caused by Loss of FUS and SFPQ Function Leads to FTLD-like Phenotypes. Cell Rep. 2017 Jan 31;18(5):1118-1131.
  17. Koike H, Kadoya M, Kaida KI, Ikeda S, Kawagashira Y, Iijima M, Kato D, Ogata H, Yamasaki R, Matsukawa N, Kira JI, Katsuno M, Sobue G. Paranodal dissection in chronic inflammatory demyelinating polyneuropathy with anti-neurofascin-155 and anti-contactin-1 antibodies. J Neurol Neurosurg Psychiatry. 2017 Jun;88(6):465-473.
  18. Koike H, Nakamura T, Ikeda S, Takahashi M, Kawagashira Y, Iijima M, Katsuno M, Sobue G. Alcoholic Myelopathy and Nutritional Deficiency. Intern Med. 2017;56(1):105-108.
  19. Suzuki M, Nakamura T, Hirayama M, Ueda M, Katsuno M, Sobue G. Cardiac parasympathetic dysfunction in the early phase of Parkinson's disease. J Neurol. 2017 Feb;264(2):333-340.
  20. Noda S, Koike H, Maeshima S, Nakanishi H, Iijima M, Matsuo K, Kimura S, Katsuno M, Sobue G. Transforming growth factor-β signaling is upregulated in sporadic inclusion body myositis. Muscle Nerve. 2017 May;55(5):741-747.
2016
  1. Yokoi S, Yasui K, Hasegawa Y, Niwa K, Noguchi Y, Tsuzuki T, Mimuro M, Sone J, Watanabe H, Katsuno M, Yoshida M, Sobue G. Pathological background of subcortical hyperintensities on diffusion-weighted images in a case of neuronal intranuclear inclusion disease. Clin Neuropathol, 2016.
  2. Yokoi D, Atsuta N, Watanabe H, Nakamura R, Hirakawa A, Ito M, Watanabe H, Katsuno M, Izumi Y, Morita M, Taniguchi A, Oda M, Abe K, Mizoguchi K, Kano O, Kuwabara S, Kaji R, Sobue G. Age of onset differentially influences the progression of regional dysfunction in sporadic amyotrophic lateral sclerosis. J Neurol, 2016; 263: 1129-1136.
  3. Watanabe H, Riku Y, Nakamura T, Hara K, Ito M, Hirayama M, Yoshida M, Katsuno M, Sobue G. Expanding concept of clinical conditions and symptoms in multiple system atrophy. Rinsho Shinkeigaku, 2016; 56: 457-464.
  4. Watanabe H, Atsuta N, Hirakawa A, Nakamura R, Nakatochi M, Ishigaki S, Iida A, Ikegawa S, Kubo M, Yokoi D, Watanabe H, Ito M, Katsuno M, Izumi Y, Morita M, Kanai K, Taniguchi A, Aiba I, Abe K, Mizoguchi K, Oda M, Kano O, Okamoto K, Kuwabara S, Hasegawa K, Imai T, Kawata A, Aoki M, Tsuji S, Nakashima K, Kaji R, Sobue G. A rapid functional decline type of amyotrophic lateral sclerosis is linked to low expression of TTN. J Neurol Neurosurg Psychiatry, 2016; 87: 851-858.
  5. Umemura T, Kawamura T, Mashita S, Kameyama T, Sobue G. Higher Levels of Cystatin C Are Associated with Extracranial Carotid Artery Steno-Occlusive Disease in Patients with Noncardioembolic Ischemic Stroke. Cerebrovasc Dis Extra, 2016; 6: 1-11.
  6. Tsujikawa K, Senda J, Yasui K, Hasegawa Y, Hoshiyama M, Katsuno M, Sobue G. Distinctive distribution of brain volume reductions in MELAS and mitochondrial DNA A3243G mutation carriers: A voxel-based morphometric study. Mitochondrion, 2016; 30: 229-235.
  7. Tsujikawa K, Hara K, Muro Y, Nakanishi H, Niwa Y, Koike M, Noda S, Riku Y, Sahashi K, Atsuta N, Ito M, Shimoyama Y, Akiyama M, Katsuno M. HMGCR antibody-associated myopathy as a paraneoplastic manifestation of esophageal carcinoma. Neurology, 2016; 87: 841-843.
  8. Tanaka Y, Tsuboi T, Watanabe H, Kajita Y, Nakatsubo D, Fujimoto Y, Ohdake R, Ito M, Atsuta N, Yamamoto M, Wakabayashi T, Katsuno M, Sobue G. Articulation Features of Parkinson's Disease Patients with Subthalamic Nucleus Deep Brain Stimulation. J Parkinsons Dis, 2016.
  9. Senda J, Ito K, Kotake T, Kanamori M, Kishimoto H, Kadono I, Suzuki Y, Katsuno M, Nishida Y, Ishiguro N, Sobue G. Association of Leukoaraiosis With Convalescent Rehabilitation Outcome in Patients With Ischemic Stroke. Stroke, 2016; 47: 160-166.
  10. Riku Y, Watanabe H, Yoshida M, Mimuro M, Iwasaki Y, Masuda M, Ishigaki S, Katsuno M, Sobue G. Marked Involvement of the Striatal Efferent System in TAR DNA-Binding Protein 43 kDa-Related Frontotemporal Lobar Degeneration and Amyotrophic Lateral Sclerosis. J Neuropathol Exp Neurol, 2016.
  11. Ohyama K, Koike H, Hashimoto R, Takahashi M, Kawagashira Y, Iijima M, Katsuno M, Sobue G. Intraepidermal nerve fibre density in POEMS (Crow-Fukase) syndrome and the correlation with sural nerve pathology. J Neurol Sci, 2016; 365: 207-211.
  12. Noda T, Iijima M, Noda S, Maeshima S, Nakanishi H, Kimura S, Koike H, Ishigaki S, Iguchi Y, Katsuno M, Sobue G. Gene Expression Profile of Inflammatory Myopathy with Malignancy is Similar to that of Dermatomyositis rather than Polymyositis. Intern Med, 2016; 55: 2571-2580.
  13. Noda S, Koike H, Maeshima S, Nakanishi H, Iijima M, Matsuo K, Kimura S, Katsuno M, Sobue G. Transforming growth factor-beta signaling is upregulated in sporadic inclusion body myositis. Muscle Nerve, 2016.
  14. Nakamura T, Suzuki M, Okada A, Suzuki J, Hasegawa S, Koike H, Hirayama M, Katsuno M, Sobue G. Association of leptin with orthostatic blood pressure changes in Parkinson's disease. Mov Disord, 2016; 31: 1417-1421.
  15. Nakamura R, Sone J, Atsuta N, Tohnai G, Watanabe H, Yokoi D, Nakatochi M, Watanabe H, Ito M, Senda J, Katsuno M, Tanaka F, Li Y, Izumi Y, Morita M, Taniguchi A, Kano O, Oda M, Kuwabara S, Abe K, Aiba I, Okamoto K, Mizoguchi K, Hasegawa K, Aoki M, Hattori N, Tsuji S, Nakashima K, Kaji R, Sobue G. Next-generation sequencing of 28 ALS-related genes in a Japanese ALS cohort. Neurobiol Aging, 2016; 39: 219 e211-218.
  16. Masuda M, Senda J, Watanabe H, Epifanio B, Tanaka Y, Imai K, Riku Y, Li Y, Nakamura R, Ito M, Ishigaki S, Atsuta N, Koike H, Katsuno M, Hattori N, Naganawa S, Sobue G. Involvement of the caudate nucleus head and its networks in sporadic amyotrophic lateral sclerosis-frontotemporal dementia continuum. Amyotroph Lateral Scler Frontotemporal Degener, 2016: 1-9.
  17. Ikumi K, Ando T, Katano H, Katsuno M, Sakai Y, Yoshida M, Saida T, Kimura H, Sobue G. HSV-2-related hemophagocytic lymphohistiocytosis in a fingolimod-treated patient with MS. Neurol Neuroimmunol Neuroinflamm, 2016; 3: e247.
  18. Hirunagi T, Tsujikawa K, Hasegawa Y, Mano K, Katsuno M. Elderly-onset familial myasthenia gravis in two siblings. Neuromuscul Disord, 2016; 26: 347-349.
  19. Hijikata Y, Katsuno M, Suzuki K, Hashizume A, Araki A, Yamada S, Inagaki T, Iida M, Noda S, Nakanishi H, Banno H, Mano T, Hirakawa A, Adachi H, Watanabe H, Yamamoto M, Sobue G. Impaired muscle uptake of creatine in spinal and bulbar muscular atrophy. Ann Clin Transl Neurol, 2016; 3: 537-546.
  20. Ding Y, Adachi H, Katsuno M, Sahashi K, Kondo N, Iida M, Tohnai G, Nakatsuji H, Sobue G. BIIB021, a synthetic Hsp90 inhibitor, induces mutant ataxin-1 degradation through the activation of heat shock factor 1. Neuroscience, 2016; 327: 20-31.
  21. Araki K, Sone J, Fujioka Y, Masuda M, Ohdake R, Tanaka Y, Nakamura T, Watanabe H, Sobue G. Memory Loss and Frontal Cognitive Dysfunction in a Patient with Adult-onset Neuronal Intranuclear Inclusion Disease. Intern Med, 2016; 55: 2281-2284.
2015
  1. Yamada S, Nakanishi H, Hirayama M, Katsuno M, Sobue G. [67Ga scintigraphy as a therapeutic marker for spinal cord and muscular sarcoidosis: A case report]. Rinsho Shinkeigaku, 2015; 55: 665-668.
  2. Watanabe H, Sobue G. Filling in the missing puzzle piece between cardiac MIBG scintigraphy findings and Parkinson's disease pathology. J Neurol Neurosurg Psychiatry, 2015; 86: 937.
  3. Watanabe H, Atsuta N, Nakamura R, Hirakawa A, Watanabe H, Ito M, Senda J, Katsuno M, Izumi Y, Morita M, Tomiyama H, Taniguchi A, Aiba I, Abe K, Mizoguchi K, Oda M, Kano O, Okamoto K, Kuwabara S, Hasegawa K, Imai T, Aoki M, Tsuji S, Nakano I, Kaji R, Sobue G. Factors affecting longitudinal functional decline and survival in amyotrophic lateral sclerosis patients. Amyotroph Lateral Scler Frontotemporal Degener, 2015; 16: 230-236.
  4. Udagawa T, Fujioka Y, Tanaka M, Honda D, Yokoi S, Riku Y, Ibi D, Nagai T, Yamada K, Watanabe H, Katsuno M, Inada T, Ohno K, Sokabe M, Okado H, Ishigaki S, Sobue G. FUS regulates AMPA receptor function and FTLD/ALS-associated behaviour via GluA1 mRNA stabilization. Nat Commun, 2015; 6: 7098.
  5. Tsuboi T, Watanabe H, Tanaka Y, Ohdake R, Yoneyama N, Hara K, Nakamura R, Watanabe H, Senda J, Atsuta N, Ito M, Hirayama M, Yamamoto M, Fujimoto Y, Kajita Y, Wakabayashi T, Sobue G. Distinct phenotypes of speech and voice disorders in Parkinson's disease after subthalamic nucleus deep brain stimulation. J Neurol Neurosurg Psychiatry, 2015; 86: 856-864.
  6. Tsuboi T, Watanabe H, Tanaka Y, Ohdake R, Yoneyama N, Hara K, Ito M, Hirayama M, Yamamoto M, Fujimoto Y, Kajita Y, Wakabayashi T, Sobue G. Characteristic laryngoscopic findings in Parkinson's disease patients after subthalamic nucleus deep brain stimulation and its correlation with voice disorder. J Neural Transm (Vienna), 2015; 122: 1663-1672.
  7. Tanaka Y, Tsuboi T, Watanabe H, Kajita Y, Fujimoto Y, Ohdake R, Yoneyama N, Masuda M, Hara K, Senda J, Ito M, Atsuta N, Horiguchi S, Yamamoto M, Wakabayashi T, Sobue G. Voice features of Parkinson's disease patients with subthalamic nucleus deep brain stimulation. J Neurol, 2015; 262: 1173-1181.
  8. Suzuki J, Nakamura T, Hirayama M, Mizutani Y, Okada A, Ito M, Watanabe H, Sobue G. Impaired peripheral vasoconstrictor response to orthostatic stress in patients with multiple system atrophy. Parkinsonism Relat Disord, 2015; 21: 917-922.
  9. Sasaki S, Iguchi Y, Katsuno M, Sobue G. Alterations in the blood-spinal cord barrier in TDP-43 conditional knockout mice. Neurosci Lett, 2015; 598: 1-5.
  10. Sahashi K, Katsuno M, Hung G, Adachi H, Kondo N, Nakatsuji H, Tohnai G, Iida M, Bennett CF, Sobue G. Silencing neuronal mutant androgen receptor in a mouse model of spinal and bulbar muscular atrophy. Hum Mol Genet, 2015; 24: 5985-5994.
  11. Okada A, Koike H, Nakamura T, Motomura M, Sobue G. Efficacy of intravenous immunoglobulin for treatment of Lambert-Eaton myasthenic syndrome without anti-presynaptic P/Q-type voltage-gated calcium channel antibodies: a case report. Neuromuscul Disord, 2015; 25: 70-72.
  12. Ohyama K, Koike H, Takahashi M, Kawagashira Y, Iijima M, Watanabe H, Sobue G. Immunoglobulin G4-related pathologic features in inflammatory neuropathies. Neurology, 2015; 85: 1400-1407.
  13. Ohyama K, Koike H, Sobue G. [Paraneoplastic neuropathy]. Nihon Rinsho, 2015; 73 Suppl 7: 782-787.
  14. Mano T, Katsuno M, Banno H, Suzuki K, Suga N, Hashizume A, Araki A, Hijikata Y, Tanaka S, Takatsu J, Watanabe H, Yamamoto M, Sobue G. Head Lift Exercise Improves Swallowing Dysfunction in Spinal and Bulbar Muscular Atrophy. Eur Neurol, 2015; 74: 251-258.
  15. Maeshima S, Koike H, Noda S, Noda T, Nakanishi H, Iijima M, Ito M, Kimura S, Sobue G. Clinicopathological features of sarcoidosis manifesting as generalized chronic myopathy. J Neurol, 2015; 262: 1035-1045.
  16. Kondo N, Ito Y, Yamashita H, Azuma F, Nokura K, Yasuda T, Sobue G. Hemodialysis-related portal-systemic encephalopathy. Intern Med, 2015; 54: 1113-1117.
  17. Koike H, Takahashi M, Ohyama K, Hashimoto R, Kawagashira Y, Iijima M, Katsuno M, Doi H, Tanaka F, Sobue G. Clinicopathologic features of folate-deficiency neuropathy. Neurology, 2015; 84: 1026-1033.
  18. Koike H, Sobue G. [Central nervous system vasculitis according to the 2012 revise international Chapel Hill consensus conference nomenclature of vasculitides]. Brain Nerve, 2015; 67: 243-248.
  19. Koike H, Sobue G. [Acute autonomic and sensory neuropathy]. Nihon Rinsho, 2015; 73 Suppl 7: 452-457.
  20. Koike H, Ohyama K, Kawagashira Y, Iijima M, Sobue G. Author response. Neurology, 2015; 85: 1091.
  21. Koike H, Akiyama K, Saito T, Sobue G. Intravenous immunoglobulin for chronic residual peripheral neuropathy in eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome): a multicenter, double-blind trial. J Neurol, 2015; 262: 752-759.
  22. Kawagashira Y, Koike H, Sobue G. [Neuropathy associated with IgM monoclonal gammopathy with anti-myelin-associated glycoprotein (MAG) antibody]. Nihon Rinsho, 2015; 73 Suppl 7: 440-445.
  23. Kawagashira Y, Koike H, Ohyama K, Hashimoto R, Iijima M, Adachi H, Katsuno M, Chapman M, Lunn M, Sobue G. Axonal loss influences the response to rituximab treatment in neuropathy associated with IgM monoclonal gammopathy with anti-myelin-associated glycoprotein antibody. J Neurol Sci, 2015; 348: 67-73.
  24. Iijima M, Sobue G. [Epidemiology and clinical symptoms of CIDP]. Nihon Rinsho, 2015; 73 Suppl 7: 400-407.
  25. Iida M, Katsuno M, Nakatsuji H, Adachi H, Kondo N, Miyazaki Y, Tohnai G, Ikenaka K, Watanabe H, Yamamoto M, Kishida K, Sobue G. Pioglitazone suppresses neuronal and muscular degeneration caused by polyglutamine-expanded androgen receptors. Hum Mol Genet, 2015; 24: 314-329.
  26. Hashizume A, Katsuno M, Suzuki K, Banno H, Suga N, Mano T, Araki A, Hijikata Y, Grunseich C, Kokkinis A, Hirakawa A, Watanabe H, Yamamoto M, Fischbeck KH, Sobue G. A functional scale for spinal and bulbar muscular atrophy: Cross-sectional and longitudinal study. Neuromuscul Disord, 2015; 25: 554-562.
  27. Hashimoto R, Koike H, Takahashi M, Ohyama K, Kawagashira Y, Iijima M, Sobue G. Uncompacted Myelin Lamellae and Nodal Ion Channel Disruption in POEMS Syndrome. J Neuropathol Exp Neurol, 2015; 74: 1127-1136.
  28. Ding Y, Adachi H, Katsuno M, Huang Z, Jiang YM, Kondo N, Iida M, Tohnai G, Nakatsuji H, Funakoshi H, Nakamura T, Sobue G. Overexpression of hepatocyte growth factor in SBMA model mice has an additive effect on combination therapy with castration. Biochem Biophys Res Commun, 2015; 468: 677-683.
  29. Araki K, Nakanishi H, Nakamura T, Atsuta N, Yamada S, Hijikata Y, Hashizume A, Suzuki K, Katsuno M, Sobue G. Myotonia-like symptoms in a patient with spinal and bulbar muscular atrophy. Neuromuscul Disord, 2015; 25: 913-915.
2014
  1. Yokoi S, Kawagashira Y, Ohyama K, Iijima M, Koike H, Watanabe H, Tatematsu A, Nakamura S, Sobue G. Mononeuritis multiplex with tumefactive cellular infiltration in a patient with reactive lymphoid hyperplasia with increased immunoglobulin G4-positive cells. Hum Pathol, 2014; 45: 427-430.
  2. Watanabe H, Yoshida M, Sobue G. [Clinical picture and diagnostic criteria of multiple system atrophy]. Rinsho Shinkeigaku, 2014; 54: 963-965.
  3. Umemura T, Senda J, Fukami Y, Mashita S, Kawamura T, Sakakibara T, Sobue G. Impact of albuminuria on early neurological deterioration and lesion volume expansion in lenticulostriate small infarcts. Stroke, 2014; 45: 587-590.
  4. Tohnai G, Adachi H, Katsuno M, Doi H, Matsumoto S, Kondo N, Miyazaki Y, Iida M, Nakatsuji H, Qiang Q, Ding Y, Watanabe H, Yamamoto M, Ohtsuka K, Sobue G. Paeoniflorin eliminates a mutant AR via NF-YA-dependent proteolysis in spinal and bulbar muscular atrophy. Hum Mol Genet, 2014; 23: 3552-3565.
  5. Tanaka S, Banno H, Katsuno M, Suzuki K, Suga N, Hashizume A, Mano T, Araki A, Watanabe H, Adachi H, Tatsumi H, Yamamoto M, Sobue G. Distinct acoustic features in spinal and bulbar muscular atrophy patients with laryngospasm. J Neurol Sci, 2014; 337: 193-200.
  6. Suga N, Katsuno M, Koike H, Banno H, Suzuki K, Hashizume A, Mano T, Iijima M, Kawagashira Y, Hirayama M, Nakamura T, Watanabe H, Tanaka F, Sobue G. Schwann cell involvement in the peripheral neuropathy of spinocerebellar ataxia type 3. Neuropathol Appl Neurobiol, 2014; 40: 628-639.
  7. Sone J, Kitagawa N, Sugawara E, Iguchi M, Nakamura R, Koike H, Iwasaki Y, Yoshida M, Takahashi T, Chiba S, Katsuno M, Tanaka F, Sobue G. Neuronal intranuclear inclusion disease cases with leukoencephalopathy diagnosed via skin biopsy. J Neurol Neurosurg Psychiatry, 2014; 85: 354-356.
  8. Sahashi K, Sobue G. [The role of RNA splicing in the pathogenesis of spinal muscular atrophy and development of its therapeutics]. Brain Nerve, 2014; 66: 1471-1480.
  9. Riku Y, Watanabe H, Yoshida M, Tatsumi S, Mimuro M, Iwasaki Y, Katsuno M, Iguchi Y, Masuda M, Senda J, Ishigaki S, Udagawa T, Sobue G. Lower motor neuron involvement in TAR DNA-binding protein of 43 kDa-related frontotemporal lobar degeneration and amyotrophic lateral sclerosis. JAMA Neurol, 2014; 71: 172-179.
  10. Riku Y, Ikenaka K, Koike H, Niimi Y, Senda J, Hashimoto R, Kawagashira Y, Tomita M, Iijima M, Sobue G. Cutaneous arteritis associated with peripheral neuropathy: two case reports. J Dermatol, 2014; 41: 266-267.
  11. Riku Y, Atsuta N, Yoshida M, Tatsumi S, Iwasaki Y, Mimuro M, Watanabe H, Ito M, Senda J, Nakamura R, Koike H, Sobue G. Differential motor neuron involvement in progressive muscular atrophy: a comparative study with amyotrophic lateral sclerosis. BMJ Open, 2014; 4: e005213.
  12. Okada A, Koike H, Nakamura T, Watanabe H, Sobue G. Slowly progressive folate-deficiency myelopathy: report of a case. J Neurol Sci, 2014; 336: 273-275.
  13. Ohyama K, Koike H, Takahashi M, Kawagashira Y, Iijima M, Sobue G. [Clinicopathological features of neuropathy associated with IgG4-related disease]. Rinsho Shinkeigaku, 2014; 54: 1047-1049.
  14. Ohyama K, Koike H, Katsuno M, Takahashi M, Hashimoto R, Kawagashira Y, Iijima M, Adachi H, Watanabe H, Sobue G. Muscle atrophy in chronic inflammatory demyelinating polyneuropathy: a computed tomography assessment. Eur J Neurol, 2014; 21: 1002-1010.
  15. Nakamura T, Hirayama M, Hara T, Mizutani Y, Suzuki J, Watanabe H, Sobue G. Role of cardiac sympathetic nerves in preventing orthostatic hypotension in Parkinson's disease. Parkinsonism Relat Disord, 2014; 20: 409-414.
  16. Mizutani Y, Nakamura T, Okada A, Suzuki J, Watanabe H, Hirayama M, Sobue G. Hyposmia and cardiovascular dysautonomia correlatively appear in early-stage Parkinson's disease. Parkinsonism Relat Disord, 2014; 20: 520-524.
  17. Mano T, Katsuno M, Banno H, Suzuki K, Suga N, Hashizume A, Araki A, Watanabe H, Tanaka S, Yamamoto M, Sobue G. Tongue pressure as a novel biomarker of spinal and bulbar muscular atrophy. Neurology, 2014; 82: 255-262.
  18. Koike H, Sobue G. What is the prototype of familial amyloid polyneuropathy? J Neurol Neurosurg Psychiatry, 2014; 85: 713.
  19. Koike H, Sobue G. [Familial amyloid polyneuropathy: clinicopathological aspects]. Brain Nerve, 2014; 66: 749-762.
  20. Katsuno M, Watanabe H, Yamamoto M, Sobue G. Potential therapeutic targets in polyglutamine-mediated diseases. Expert Rev Neurother, 2014; 14: 1215-1228.
  21. Honda D, Ishigaki S, Iguchi Y, Fujioka Y, Udagawa T, Masuda A, Ohno K, Katsuno M, Sobue G. Corrigendum to \\\"The ALS/FTLD-related RNA-binding proteins TDP-43 and FUS have common downstream RNA targets in cortical neurons\\\" [FEBS Open Bio 4 (2014) 1-10]. FEBS Open Bio, 2014; 4: 1030.
  22. Hijikata Y, Ando T, Inagaki T, Watanabe H, Ito M, Sobue G. [Spinal cord compression due to extramedullary hematopoiesis in a patient with myelofibrosis]. Rinsho Shinkeigaku, 2014; 54: 27-31.
  23. Hara K, Watanabe H, Ito M, Tsuboi T, Watanabe H, Nakamura R, Senda J, Atsuta N, Adachi H, Aiba I, Naganawa S, Sobue G. Potential of a new MRI for visualizing cerebellar involvement in progressive supranuclear palsy. Parkinsonism Relat Disord, 2014; 20: 157-161.
  24. Atsuta N, Nakamura R, Watanabe H, Sobue G. [Japanese Consortium for Amyotrophic Lateral Sclerosis research (JaCALS)]. Brain Nerve, 2014; 66: 1090-1096.
  25. Araki A, Katsuno M, Suzuki K, Banno H, Suga N, Hashizume A, Mano T, Hijikata Y, Nakatsuji H, Watanabe H, Yamamoto M, Makiyama T, Ohno S, Fukuyama M, Morimoto S, Horie M, Sobue G. Brugada syndrome in spinal and bulbar muscular atrophy. Neurology, 2014; 82: 1813-1821.
2013
  1. Yokoi S, Yasui K, Hasegawa Y, Kasai T, Inagaki A, Sobue G. [A case of hypoglycemic coma with good outcome despite sustained unconsciousness and widespread leukoencephalopathy]. Rinsho Shinkeigaku, 2013; 53: 724-727.
  2. Watanabe H, Sobue G. A milestone on the way to therapy for MSA. Lancet Neurol, 2013; 12: 222-223.
  3. Watanabe H, Senda J, Kato S, Ito M, Atsuta N, Hara K, Tsuboi T, Katsuno M, Nakamura T, Hirayama M, Adachi H, Naganawa S, Sobue G. Cortical and subcortical brain atrophy in Parkinson's disease with visual hallucination. Mov Disord, 2013; 28: 1732-1736.
  4. Watanabe H, Senda J, Ito M, Atsuta N, Haram K, Watanabe H, Nakamura R, Tsuboi T, Yoshida M, Naganawa S, Sobue G. [Cutting-edge MRI techniques for studying neurological diseases focusing on spinocerebellar degeneration]. Rinsho Shinkeigaku, 2013; 53: 1087-1090.
  5. Umemura T, Kawamura T, Umegaki H, Kawano N, Mashita S, Sakakibara T, Hotta N, Sobue G. Association of chronic kidney disease and cerebral small vessel disease with cognitive impairment in elderly patients with type 2 diabetes. Dement Geriatr Cogn Dis Extra, 2013; 3: 212-222.
  6. Tomita M, Koike H, Kawagashira Y, Iijima M, Adachi H, Taguchi J, Abe T, Sako K, Tsuji Y, Nakagawa M, Kanda F, Takeda F, Sugawara M, Toyoshima I, Asano N, Sobue G. Clinicopathological features of neuropathy associated with lymphoma. Brain, 2013; 136: 2563-2578.
  7. Tanaka F, Sone J, Atsuta N, Nakamura R, Doi H, Koyano S, Sobue G. [Personal genome analysis in amyotrophic lateral sclerosis]. Brain Nerve, 2013; 65: 257-265.
  8. Takagi S, Iguchi Y, Katsuno M, Ishigaki S, Ikenaka K, Fujioka Y, Honda D, Niwa J, Tanaka F, Watanabe H, Adachi H, Sobue G. RNP2 of RNA recognition motif 1 plays a central role in the aberrant modification of TDP-43. PLoS One, 2013; 8: e66966.
  9. Suzuki J, Tanaka Y, Watanabe H, Ito M, Kajita Y, Sobue G. [A case of Parkinson's disease treated effectively with a pacing board for repetitive speech phenomena after deep brain stimulation]. Rinsho Shinkeigaku, 2013; 53: 304-307.
  10. Sobue G. [MicroRNA in neurodegenerative disorders]. Rinsho Shinkeigaku, 2013; 53: 942-944.
  11. Riku Y, Ito M, Atsuta N, Watanabe H, Momota H, Sobue G. [Intracranial germinoma masquerading as a granulomatous inflammation, diagnostic failure after brain biopsy]. Rinsho Shinkeigaku, 2013; 53: 835-838.
  12. Qiang Q, Adachi H, Huang Z, Jiang YM, Katsuno M, Minamiyama M, Doi H, Matsumoto S, Kondo N, Miyazaki Y, Iida M, Tohnai G, Sobue G. Genistein, a natural product derived from soybeans, ameliorates polyglutamine-mediated motor neuron disease. J Neurochem, 2013; 126: 122-130.
  13. Ohyama K, Yasui K, Hasegawa Y, Morozumi S, Koike H, Sobue G. Differential recovery in cardiac and vasomotor sympathetic functional markers in a patient with acute autonomic sensory and motor neuropathy. Intern Med, 2013; 52: 497-502.
  14. Ohyama K, Koike H, Masuda M, Sone J, Hashimoto R, Tomita M, Kawagashira Y, Iijima M, Nakamura T, Watanabe H, Sobue G. Autonomic manifestations in acute sensory ataxic neuropathy: a case report. Auton Neurosci, 2013; 179: 155-158.
  15. Ohyama K, Koike H, Iijima M, Hashimoto R, Tomita M, Kawagashira Y, Satou A, Nakamura S, Sobue G. IgG4-related neuropathy: a case report. JAMA Neurol, 2013; 70: 502-505.
  16. Nakanishi H, Koike H, Matsuo K, Tanaka F, Noda T, Fujikake A, Kimura S, Katsuno M, Doyu M, Watanabe H, Sobue G. Demographic features of Japanese patients with sporadic inclusion body myositis: a single-center referral experience. Intern Med, 2013; 52: 333-337.
  17. Nakamura R, Atsuta N, Watanabe H, Hirakawa A, Watanabe H, Ito M, Senda J, Katsuno M, Tanaka F, Izumi Y, Morita M, Ogaki K, Taniguchi A, Aiba I, Mizoguchi K, Okamoto K, Hasegawa K, Aoki M, Kawata A, Abe K, Oda M, Konagaya M, Imai T, Nakagawa M, Tsuji S, Kaji R, Nakano I, Sobue G. Neck weakness is a potent prognostic factor in sporadic amyotrophic lateral sclerosis patients. J Neurol Neurosurg Psychiatry, 2013; 84: 1365-1371.
  18. Kondo N, Katsuno M, Adachi H, Minamiyama M, Doi H, Matsumoto S, Miyazaki Y, Iida M, Tohnai G, Nakatsuji H, Ishigaki S, Fujioka Y, Watanabe H, Tanaka F, Nakai A, Sobue G. Heat shock factor-1 influences pathological lesion distribution of polyglutamine-induced neurodegeneration. Nat Commun, 2013; 4: 1405.
  19. Koike H, Yoshida H, Ito T, Ohyama K, Hashimoto R, Kawagashira Y, Iijima M, Sobue G. Demyelinating neuropathy and autoimmune hemolytic anemia in a patient with pancreatic cancer. Intern Med, 2013; 52: 1737-1740.
  20. Koike H, Watanabe H, Sobue G. The spectrum of immune-mediated autonomic neuropathies: insights from the clinicopathological features. J Neurol Neurosurg Psychiatry, 2013; 84: 98-106.
  21. Koike H, Sobue G. Clinicopathological features of neuropathy in anti-neutrophil cytoplasmic antibody-associated vasculitis. Clin Exp Nephrol, 2013; 17: 683-685.
  22. Koike H, Sobue G. Paraneoplastic neuropathy. Handb Clin Neurol, 2013; 115: 713-726.
  23. Koike H, Sobue G. [Sjogren's syndrome-associated neuropathy]. Brain Nerve, 2013; 65: 1333-1342.
  24. Koike H, Sobue G. [Autoimmune autonomic ganglionopathy and acute autonomic and sensory neuropathy]. Rinsho Shinkeigaku, 2013; 53: 1326-1329.
  25. Katsuno M, Ikenaka K, Kawai K, Sobue G. [Dysfunction of dynactin 1 in motor neuron degeneration]. Rinsho Shinkeigaku, 2013; 53: 1084-1086.
  26. Ishihara T, Ito M, Niimi Y, Tsujimoto M, Senda J, Kawai Y, Watanabe H, Ishigami M, Ito T, Kamei H, Onishi Y, Nakamura T, Goto H, Naganawa S, Kiuchi T, Sobue G. Clinical and radiological impact of liver transplantation for brain in cirrhosis patients without hepatic encephalopathy. Clin Neurol Neurosurg, 2013; 115: 2341-2347.
  27. Ikenaka K, Kawai K, Katsuno M, Huang Z, Jiang YM, Iguchi Y, Kobayashi K, Kimata T, Waza M, Tanaka F, Mori I, Sobue G. dnc-1/dynactin 1 knockdown disrupts transport of autophagosomes and induces motor neuron degeneration. PLoS One, 2013; 8: e54511.
  28. Iijima M, Koike H, Sobue G. [Therapeutic strategy for CIDP (chronic inflammatory demyelinating polyneuropathy)]. Nihon Rinsho, 2013; 71: 855-860.
  29. Iguchi Y, Katsuno M, Niwa J, Takagi S, Ishigaki S, Ikenaka K, Kawai K, Watanabe H, Yamanaka K, Takahashi R, Misawa H, Sasaki S, Tanaka F, Sobue G. Loss of TDP-43 causes age-dependent progressive motor neuron degeneration. Brain, 2013; 136: 1371-1382.
  30. Iguchi Y, Katsuno M, Ikenaka K, Ishigaki S, Sobue G. Amyotrophic lateral sclerosis: an update on recent genetic insights. J Neurol, 2013; 260: 2917-2927.
  31. Honda D, Ishigaki S, Iguchi Y, Fujioka Y, Udagawa T, Masuda A, Ohno K, Katsuno M, Sobue G. The ALS/FTLD-related RNA-binding proteins TDP-43 and FUS have common downstream RNA targets in cortical neurons. FEBS Open Bio, 2013; 4: 1-10.
  32. Hirayama M, Nakamura T, Sobue G. [Cardiac reserve in Parkinson's disease and exercise therapy]. Rinsho Shinkeigaku, 2013; 53: 1376-1378.
  33. Hijikata Y, Watanabe H, Ito M, Yoneyama N, Atsuta N, Sobue G. [Reversible cerebral vasoconstriction syndrome (RCVS) triggered by nicotine patches]. Rinsho Shinkeigaku, 2013; 53: 721-723.
  34. Hara T, Hirayama M, Mizutani Y, Hama T, Hori N, Nakamura T, Kato S, Watanabe H, Sobue G. Impaired pain processing in Parkinson's disease and its relative association with the sense of smell. Parkinsonism Relat Disord, 2013; 19: 43-46.
  35. Fujioka Y, Ishigaki S, Masuda A, Iguchi Y, Udagawa T, Watanabe H, Katsuno M, Ohno K, Sobue G. FUS-regulated region- and cell-type-specific transcriptome is associated with cell selectivity in ALS/FTLD. Sci Rep, 2013; 3: 2388.
  36. Doi H, Adachi H, Katsuno M, Minamiyama M, Matsumoto S, Kondo N, Miyazaki Y, Iida M, Tohnai G, Qiang Q, Tanaka F, Yanagawa T, Warabi E, Ishii T, Sobue G. p62/SQSTM1 differentially removes the toxic mutant androgen receptor via autophagy and inclusion formation in a spinal and bulbar muscular atrophy mouse model. J Neurosci, 2013; 33: 7710-7727.
2012
  1. Umemura T, Kawamura T, Sakakibara T, Mashita S, Hotta N, Sobue G. Microalbuminuria is independently associated with deep or infratentorial brain microbleeds in hypertensive adults. Am J Hypertens, 2012; 25: 430-436.
  2. Tanaka F, Katsuno M, Banno H, Suzuki K, Adachi H, Sobue G. Current status of treatment of spinal and bulbar muscular atrophy. Neural Plast, 2012; 2012: 369284.
  3. Tanaka F, Ikenaka K, Yamamoto M, Sobue G. Neuropathology and omics in motor neuron diseases. Neuropathology, 2012; 32: 458-462.
  4. Tamura T, Yoshida M, Hashizume Y, Sobue G. Lewy body-related alpha-synucleinopathy in the spinal cord of cases with incidental Lewy body disease. Neuropathology, 2012; 32: 13-22.
  5. Suzuki K, Banno H, Katsuno M, Adachi H, Tanaka F, Sobue G. [Disease-modifying therapy for spinal and bulbar muscular atrophy (SBMA)]. Brain Nerve, 2012; 64: 237-244.
  6. Sobue G. [Perspectives of therapy development from academia]. Brain Nerve, 2012; 64: 221-223.
  7. Sobue G. [109th Scientific Meeting of the Japanese Society of Internal Medicine: invited lecture : 3. Progress in research on motor neuron diseases and therapy perspectives]. Nihon Naika Gakkai Zasshi, 2012; 101: 2479-2487.
  8. Senda J, Watanabe H, Tsuboi T, Hara K, Watanabe H, Nakamura R, Ito M, Atsuta N, Tanaka F, Naganawa S, Sobue G. MRI mean diffusivity detects widespread brain degeneration in multiple sclerosis. J Neurol Sci, 2012; 319: 105-110.
  9. Ogaki K, Li Y, Atsuta N, Tomiyama H, Funayama M, Watanabe H, Nakamura R, Yoshino H, Yato S, Tamura A, Naito Y, Taniguchi A, Fujita K, Izumi Y, Kaji R, Hattori N, Sobue G. Analysis of C9orf72 repeat expansion in 563 Japanese patients with amyotrophic lateral sclerosis. Neurobiol Aging, 2012; 33: 2527 e2511-2526.
  10. Miyazaki Y, Hirayama M, Watanabe H, Usami N, Yokoi K, Watanabe O, Sobue G. Paraneoplastic encephalitis associated with myasthenia gravis and malignant thymoma. J Clin Neurosci, 2012; 19: 336-338.
  11. Miyazaki Y, Adachi H, Katsuno M, Minamiyama M, Jiang YM, Huang Z, Doi H, Matsumoto S, Kondo N, Iida M, Tohnai G, Tanaka F, Muramatsu S, Sobue G. Viral delivery of miR-196a ameliorates the SBMA phenotype via the silencing of CELF2. Nat Med, 2012; 18: 1136-1141.
  12. Minamiyama M, Katsuno M, Adachi H, Doi H, Kondo N, Iida M, Ishigaki S, Fujioka Y, Matsumoto S, Miyazaki Y, Tanaka F, Kurihara H, Sobue G. Naratriptan mitigates CGRP1-associated motor neuron degeneration caused by an expanded polyglutamine repeat tract. Nat Med, 2012; 18: 1531-1538.
  13. Mano T, Katsuno M, Banno H, Suzuki K, Suga N, Hashizume A, Tanaka F, Sobue G. Cross-sectional and longitudinal analysis of an oxidative stress biomarker for spinal and bulbar muscular atrophy. Muscle Nerve, 2012; 46: 692-697.
  14. Koike H, Tanaka F, Hashimoto R, Tomita M, Kawagashira Y, Iijima M, Fujitake J, Kawanami T, Kato T, Yamamoto M, Sobue G. Natural history of transthyretin Val30Met familial amyloid polyneuropathy: analysis of late-onset cases from non-endemic areas. J Neurol Neurosurg Psychiatry, 2012; 83: 152-158.
  15. Koike H, Sobue G. Late-onset familial amyloid polyneuropathy in Japan. Amyloid, 2012; 19 Suppl 1: 55-57.
  16. Koike H, Hashimoto R, Tomita M, Kawagashira Y, Iijima M, Nakamura T, Watanabe H, Kamei H, Kiuchi T, Sobue G. Impact of aging on the progression of neuropathy after liver transplantation in transthyretin Val30Met amyloidosis. Muscle Nerve, 2012; 46: 964-970.
  17. Koike H, Hashimoto R, Tomita M, Kawagashira Y, Iijima M, Koyano S, Momoo T, Yuasa H, Mitake S, Higashihara M, Kaida K, Yamamoto D, Hisahara S, Shimohama S, Nakae Y, Johkura K, Vernino S, Sobue G. The spectrum of clinicopathological features in pure autonomic neuropathy. J Neurol, 2012; 259: 2067-2075.
  18. Koike H, Hama T, Kawagashira Y, Hashimoto R, Tomita M, Iijima M, Sobue G. The significance of folate deficiency in alcoholic and nutritional neuropathies: analysis of a case. Nutrition, 2012; 28: 821-824.
  19. Kawagashira Y, Koike H, Fujioka Y, Hashimoto R, Tomita M, Morozumi S, Iijima M, Katsuno M, Tanaka F, Sobue G. Differential, size-dependent sensory neuron involvement in the painful and ataxic forms of primary Sjogren's syndrome-associated neuropathy. J Neurol Sci, 2012; 319: 139-146.
  20. Katsuno M, Tanaka F, Sobue G. Perspectives on molecular targeted therapies and clinical trials for neurodegenerative diseases. J Neurol Neurosurg Psychiatry, 2012; 83: 329-335.
  21. Katsuno M, Tanaka F, Adachi H, Banno H, Suzuki K, Watanabe H, Sobue G. Pathogenesis and therapy of spinal and bulbar muscular atrophy (SBMA). Prog Neurobiol, 2012; 99: 246-256.
  22. Katsuno M, Banno H, Suzuki K, Hashizume A, Adachi H, Tanaka F, Sobue G. [Anti-androgen therapy for spinal and bulbar muscular atrophy (SBMA)]. Rinsho Shinkeigaku, 2012; 52: 1207-1209.
  23. Katsuno M, Banno H, Suzuki K, Hashizume A, Adachi H, Tanaka F, Sobue G. [109th Scientific Meeting of the Japanese Society of Internal Medicine: symposium: 2. Translational research and evidence-based medicine (EBM) in internal medicine in Japan, translational research; 1) Translational research on neurodegenerative diseases]. Nihon Naika Gakkai Zasshi, 2012; 101: 2533-2538.
  24. Katsuno M, Banno H, Suzuki K, Adachi H, Tanaka F, Sobue G. Molecular pathophysiology and disease-modifying therapies for spinal and bulbar muscular atrophy. Arch Neurol, 2012; 69: 436-440.
  25. Katsumata R, Ishigaki S, Katsuno M, Kawai K, Sone J, Huang Z, Adachi H, Tanaka F, Urano F, Sobue G. c-Abl inhibition delays motor neuron degeneration in the G93A mouse, an animal model of amyotrophic lateral sclerosis. PLoS One, 2012; 7: e46185.
  26. Kato S, Watanabe H, Senda J, Hirayama M, Ito M, Atsuta N, Kaga T, Katsuno M, Naganawa S, Sobue G. Widespread cortical and subcortical brain atrophy in Parkinson's disease with excessive daytime sleepiness. J Neurol, 2012; 259: 318-326.
  27. Ishihara T, Ito M, Watanabe H, Ishigami M, Kiuchi T, Sobue G. [Case of acquired hepatocerebral degeneration with prominent improvement of parkinsonism and cognitive deficits after living-donor liver transplantation]. Rinsho Shinkeigaku, 2012; 52: 581-584.
  28. Ikenaka K, Katsuno M, Kawai K, Ishigaki S, Tanaka F, Sobue G. Disruption of axonal transport in motor neuron diseases. Int J Mol Sci, 2012; 13: 1225-1238.
  29. Iijima M, Koike H, Sobue G. [Efficacy and availability of intravenous immunoglobulin in chronic inflammatory demyelinating polyneuropathy]. Nihon Rinsho, 2012; 70: 715-721.
  30. Iida M, Koike H, Ando T, Sugiura M, Yamamoto M, Tanaka F, Sobue G. A novel MPZ mutation in Charcot-Marie-Tooth disease type 1B with focally folded myelin and multiple entrapment neuropathies. Neuromuscul Disord, 2012; 22: 166-169.
  31. Iguchi Y, Katsuno M, Takagi S, Ishigaki S, Niwa J, Hasegawa M, Tanaka F, Sobue G. Oxidative stress induced by glutathione depletion reproduces pathological modifications of TDP-43 linked to TDP-43 proteinopathies. Neurobiol Dis, 2012; 45: 862-870.
  32. Hashizume A, Katsuno M, Banno H, Suzuki K, Suga N, Tanaka F, Sobue G. Difference in chronological changes of outcome measures between untreated and placebo-treated patients of spinal and bulbar muscular atrophy. J Neurol, 2012; 259: 712-719.
  33. Hashizume A, Katsuno M, Banno H, Suzuki K, Suga N, Mano T, Atsuta N, Oe H, Watanabe H, Tanaka F, Sobue G. Longitudinal changes of outcome measures in spinal and bulbar muscular atrophy. Brain, 2012; 135: 2838-2848.
  34. Hama T, Hirayama M, Hara T, Nakamura T, Atsuta N, Banno H, Suzuki K, Katsuno M, Tanaka F, Sobue G. Discrimination of spinal and bulbar muscular atrophy from amyotrophic lateral sclerosis using sensory nerve action potentials. Muscle Nerve, 2012; 45: 169-174.
  35. Banno H, Katsuno M, Suzuki K, Tanaka F, Sobue G. Pathogenesis and molecular targeted therapy of spinal and bulbar muscular atrophy (SBMA). Cell Tissue Res, 2012; 349: 313-320.
2011
  1. Watanabe H, Yoshida M, Naganawa S, Sobue G. [The diagnosis of neurodegenerative disorders based on clinical and pathological findings using an MRI approach]. Rinsho Shinkeigaku, 2011; 51: 863-864.
  2. Umemura T, Kawamura T, Umegaki H, Mashita S, Kanai A, Sakakibara T, Hotta N, Sobue G. Endothelial and inflammatory markers in relation to progression of ischaemic cerebral small-vessel disease and cognitive impairment: a 6-year longitudinal study in patients with type 2 diabetes mellitus. J Neurol Neurosurg Psychiatry, 2011; 82: 1186-1194.
  3. Uchida K, Hirayama M, Yamashita F, Hori N, Nakamura T, Sobue G. Tremor is attenuated during walking in essential tremor with resting tremor but not parkinsonian tremor. J Clin Neurosci, 2011; 18: 1224-1228.
  4. Tsujimoto M, Senda J, Ishihara T, Niimi Y, Kawai Y, Atsuta N, Watanabe H, Tanaka F, Naganawa S, Sobue G. Behavioral changes in early ALS correlate with voxel-based morphometry and diffusion tensor imaging. J Neurol Sci, 2011; 307: 34-40.
  5. Tanaka F, Ikenaka K, Sobue G. [Role of axonal transport in ALS]. Rinsho Shinkeigaku, 2011; 51: 1189-1191.
  6. Sone J, Tanaka F, Koike H, Inukai A, Katsuno M, Yoshida M, Watanabe H, Sobue G. Skin biopsy is useful for the antemortem diagnosis of neuronal intranuclear inclusion disease. Neurology, 2011; 76: 1372-1376.
  7. Sobue G. [Development of disease-modifying therapy for neurodegenerative diseases]. Rinsho Shinkeigaku, 2011; 51: 821-824.
  8. Senda J, Kato S, Kaga T, Ito M, Atsuta N, Nakamura T, Watanabe H, Tanaka F, Naganawa S, Sobue G. Progressive and widespread brain damage in ALS: MRI voxel-based morphometry and diffusion tensor imaging study. Amyotroph Lateral Scler, 2011; 12: 59-69.
  9. Nakamura T, Hirayama M, Hara T, Hama T, Watanabe H, Sobue G. Does cardiovascular autonomic dysfunction contribute to fatigue in Parkinson's disease? Mov Disord, 2011; 26: 1869-1874.
  10. Morozumi S, Koike H, Tomita M, Kawagashira Y, Iijima M, Katsuno M, Hattori N, Tanaka F, Sobue G. Spatial distribution of nerve fiber pathology and vasculitis in microscopic polyangiitis-associated neuropathy. J Neuropathol Exp Neurol, 2011; 70: 340-348.
  11. Miyazaki Y, Koike H, Ito M, Atsuta N, Watanabe H, Katsuno M, Kusunoki S, Sobue G. Acute superficial sensory neuropathy with generalized anhidrosis, anosmia, and ageusia. Muscle Nerve, 2011; 43: 286-288.
  12. Miyazaki Y, Koike H, Akane A, Shibata Y, Nishiwaki K, Sobue G. Spinal cord stimulation markedly ameliorated refractory neuropathic pain in transthyretin Val30Met familial amyloid polyneuropathy. Amyloid, 2011; 18: 87-90.
  13. Koike H, Tanaka F, Sobue G. Paraneoplastic neuropathy: wide-ranging clinicopathological manifestations. Curr Opin Neurol, 2011; 24: 504-510.
  14. Koike H, Sobue G. [Clinicopathological features of familial amyloid polyneuropathy]. Rinsho Shinkeigaku, 2011; 51: 1134-1137.
  15. Koike H, Kiuchi T, Iijima M, Ueda M, Ando Y, Morozumi S, Tomita M, Kawagashira Y, Watanabe H, Katsuno M, Shimoyama Y, Okazaki Y, Kamei H, Sobue G. Systemic but asymptomatic transthyretin amyloidosis 8 years after domino liver transplantation. J Neurol Neurosurg Psychiatry, 2011; 82: 1287-1290.
  16. Koike H, Hashimoto R, Tomita M, Kawagashira Y, Iijima M, Tanaka F, Sobue G. Diagnosis of sporadic transthyretin Val30Met familial amyloid polyneuropathy: a practical analysis. Amyloid, 2011; 18: 53-62.
  17. Koike H, Hashimoto R, Tomita M, Kawagashira Y, Iijima M, Nagamatsu M, Sobue G. The wide range of clinical manifestations in leprous neuropathy: two case reports. Intern Med, 2011; 50: 2223-2226.
  18. Katsuno M, Banno H, Suzuki K, Adachi H, Tanaka F, Sobue G. [TGF-beta signaling in neurodegenerative diseases]. Rinsho Shinkeigaku, 2011; 51: 982-985.
  19. Katsuno M, Adachi H, Banno H, Suzuki K, Tanaka F, Sobue G. Transforming growth factor-beta signaling in motor neuron diseases. Curr Mol Med, 2011; 11: 48-56.
  20. Ito M, Watanabe H, Sobue G. [Clinical concepts and diagnostic criteria of progressive supranuclear palsy]. Nihon Rinsho, 2011; 69 Suppl 10 Pt 2: 394-398.
  21. Iijima M, Koike H, Katsuno M, Sobue G. Polymorphism of transient axonal glycoprotein-1 in chronic inflammatory demyelinating polyneuropathy. J Peripher Nerv Syst, 2011; 16 Suppl 1: 52-55.
  22. Hirayama M, Nakamura T, Watanabe H, Uchida K, Hama T, Hara T, Niimi Y, Ito M, Ohno K, Sobue G. Urinary 8-hydroxydeoxyguanosine correlate with hallucinations rather than motor symptoms in Parkinson's disease. Parkinsonism Relat Disord, 2011; 17: 46-49.
  23. Hashizume A, Watanabe H, Matsuo K, Katsuno M, Tanaka F, Nagatani T, Sobue G. Endoscopic third ventriculotomy improves parkinsonism following a ventriculo-peritoneal shunt in a patient with non-communicating hydrocephalus secondary to idiopathic aqueduct stenosis. J Neurol Sci, 2011; 309: 148-150.
  24. Hashizume A, Koike H, Kawagashira Y, Banno H, Suzuki K, Ito M, Katsuno M, Watanabe H, Tanaka F, Naganawa S, Kaneko R, Ishii A, Sobue G. Central nervous system involvement in n-hexane polyneuropathy demonstrated by MRI and proton MR spectroscopy. Clin Neurol Neurosurg, 2011; 113: 493-495.
  25. Banno H, Katsuno M, Suzuki K, Sobue G. Dutasteride for spinal and bulbar muscular atrophy. Lancet Neurol, 2011; 10: 113-115.
  26. Atsuta N, Watanabe H, Ito M, Nakamura R, Senda J, Kato S, Sobue G. [Development of a telephone survey system for patients with amyotrophic lateral sclerosis using the ALSFRS-R (Japanese version) and application of this system in a longitudinal multicenter study]. Brain Nerve, 2011; 63: 491-496.
  27. Atsuta N, Nakamura R, Watanabe H, Watanabe H, Ito M, Senda J, Tanaka F, Sobue G. [JaCALS: a prospective multicenter ALS cohort study]. Rinsho Shinkeigaku, 2011; 51: 903-905.
2010
  1. Yamashita F, Hirayama M, Nakamura T, Takamori M, Hori N, Uchida K, Hama T, Sobue G. Pupillary autonomic dysfunction in multiple system atrophy and Parkinson's disease: an assessment by eye-drop tests. Clin Auton Res, 2010; 20: 191-197.
  2. Watanabe H, Ito M, Fukatsu H, Senda J, Atsuta N, Kaga T, Kato S, Katsuno M, Tanaka F, Hirayama M, Naganawa S, Sobue G. Putaminal magnetic resonance imaging features at various magnetic field strengths in multiple system atrophy. Mov Disord, 2010; 25: 1916-1923.
  3. Tomita M, Watanabe H, Morozumi S, Kawagashira Y, Iijima M, Nakamura T, Katsuno M, Koike H, Hattori N, Hirayama M, Kusunoki S, Sobue G. Pyramidal tract involvement in Guillain-Barre syndrome associated with anti-GM1 antibody. J Neurol Neurosurg Psychiatry, 2010; 81: 583-585.
  4. Suzuki K, Katsuno M, Banno H, Takeuchi Y, Kawashima M, Suga N, Hashizume A, Hama T, Uchida K, Yamashita F, Nakamura T, Hirayama M, Tanaka F, Sobue G. The profile of motor unit number estimation (MUNE) in spinal and bulbar muscular atrophy. J Neurol Neurosurg Psychiatry, 2010; 81: 567-571.
  5. Sone J, Niwa J, Kawai K, Ishigaki S, Yamada S, Adachi H, Katsuno M, Tanaka F, Doyu M, Sobue G. Dorfin ameliorates phenotypes in a transgenic mouse model of amyotrophic lateral sclerosis. J Neurosci Res, 2010; 88: 123-135.
  6. Sobue G. [Molecular-targeted therapy for spinal and bulbar muscular atrophy (SBMA)]. Rinsho Shinkeigaku, 2010; 50: 839-841.
  7. Senda J, Ito M, Atsuta N, Watanabe H, Hattori N, Kawai H, Sobue G. Paradoxical brain embolism induced by Mycoplasma pneumoniae infection with deep venous thrombus. Intern Med, 2010; 49: 2003-2005.
  8. Nakamura T, Hirayama M, Yamashita F, Uchida K, Hama T, Watanabe H, Sobue G. Lowered cardiac sympathetic nerve performance in response to exercise in Parkinson's disease. Mov Disord, 2010; 25: 1183-1189.
  9. Koike H, Sobue G. Diagnosis of familial amyloid polyneuropathy: wide-ranged clinicopathological features. Expert Opin Med Diagn, 2010; 4: 323-331.
  10. Koike H, Sobue G. Expanding the concept of inflammatory neuropathies. Brain, 2010; 133: 2848-2851.
  11. Koike H, Koyano S, Morozumi S, Kawagashira Y, Iijima M, Katsuno M, Hattori N, Vernino S, Sobue G. Slowly progressive autonomic neuropathy with antiganglionic acetylcholine receptor antibody. J Neurol Neurosurg Psychiatry, 2010; 81: 586-587.
  12. Koike H, Atsuta N, Adachi H, Iijima M, Katsuno M, Yasuda T, Fukada Y, Yasui K, Nakashima K, Horiuchi M, Shiomi K, Fukui K, Takashima S, Morita Y, Kuniyoshi K, Hasegawa Y, Toribe Y, Kajiura M, Takeshita S, Mukai E, Sobue G. Clinicopathological features of acute autonomic and sensory neuropathy. Brain, 2010; 133: 2881-2896.
  13. Kawagashira Y, Watanabe H, Morozumi S, Iijima I, Koike H, Hattori N, Sobue G. Differential response to intravenous immunoglobulin (IVIg) therapy among multifocal and polyneuropathy types of painful diabetic neuropathy. J Clin Neurosci, 2010; 17: 1003-1008.
  14. Kawagashira Y, Kondo N, Atsuta N, Iijima M, Koike H, Katsuno M, Tanaka F, Kusunoki S, Sobue G. IgM MGUS anti-MAG neuropathy with predominant muscle weakness and extensive muscle atrophy. Muscle Nerve, 2010; 42: 433-435.
  15. Kawagashira Y, Koike H, Tomita M, Morozumi S, Iijima M, Nakamura T, Katsuno M, Tanaka F, Sobue G. Morphological progression of myelin abnormalities in IgM-monoclonal gammopathy of undetermined significance anti-myelin-associated glycoprotein neuropathy. J Neuropathol Exp Neurol, 2010; 69: 1143-1157.
  16. Katsuno M, Banno H, Suzuki K, Takeuchi Y, Kawashima M, Yabe I, Sasaki H, Aoki M, Morita M, Nakano I, Kanai K, Ito S, Ishikawa K, Mizusawa H, Yamamoto T, Tsuji S, Hasegawa K, Shimohata T, Nishizawa M, Miyajima H, Kanda F, Watanabe Y, Nakashima K, Tsujino A, Yamashita T, Uchino M, Fujimoto Y, Tanaka F, Sobue G. Efficacy and safety of leuprorelin in patients with spinal and bulbar muscular atrophy (JASMITT study): a multicentre, randomised, double-blind, placebo-controlled trial. Lancet Neurol, 2010; 9: 875-884.
  17. Katsuno M, Banno H, Suzuki K, Adachi H, Tanaka F, Sobue G. Clinical features and molecular mechanisms of spinal and bulbar muscular atrophy (SBMA). Adv Exp Med Biol, 2010; 685: 64-74.
  18. Katsuno M, Adachi H, Minamiyama M, Waza M, Doi H, Kondo N, Mizoguchi H, Nitta A, Yamada K, Banno H, Suzuki K, Tanaka F, Sobue G. Disrupted transforming growth factor-beta signaling in spinal and bulbar muscular atrophy. J Neurosci, 2010; 30: 5702-5712.
  19. Katada E, Nakamura T, Watanabe H, Matsukawa N, Ojika K, Sobue G. [Lambert-Eaton myasthenic syndrome associated with pulmonary squamous cell carcinoma and circulating anti-P/Q-type voltage-gated calcium channel antibody]. Rinsho Shinkeigaku, 2010; 50: 17-19.
  20. Atsuta N, Sobue G. [Japanese consortium for amyotrophic lateral sclerosis research (JaCALS)]. Rinsho Shinkeigaku, 2010; 50: 928-930.
2009
  1. Watanabe H, Hirayama M, Noda A, Ito M, Atsuta N, Senda J, Kaga T, Yamada A, Katsuno M, Niwa T, Tanaka F, Sobue G. B-type natriuretic peptide and cardiovalvulopathy in Parkinson disease with dopamine agonist. Neurology, 2009; 72: 621-626.
  2. Tokui K, Adachi H, Waza M, Katsuno M, Minamiyama M, Doi H, Tanaka K, Hamazaki J, Murata S, Tanaka F, Sobue G. 17-DMAG ameliorates polyglutamine-mediated motor neuron degeneration through well-preserved proteasome function in an SBMA model mouse. Hum Mol Genet, 2009; 18: 898-910.
  3. Tanaka F, Waza M, Yamamoto M, Sobue G. [Exploration of pathogenesis and therapy development for ALS employing sporadic disease model]. Rinsho Shinkeigaku, 2009; 49: 811-813.
  4. Suzuki K, Kastuno M, Banno H, Sobue G. Pathogenesis-targeting therapeutics for spinal and bulbar muscular atrophy (SBMA). Neuropathology, 2009; 29: 509-516.
  5. Sobue G. [Molecular-targeted therapy for neurodegenerative diseases]. Rinsho Shinkeigaku, 2009; 49: 747-749.
  6. Senda J, Ito M, Watanabe H, Atsuta N, Kawai Y, Katsuno M, Tanaka F, Naganawa S, Fukatsu H, Sobue G. Correlation between pyramidal tract degeneration and widespread white matter involvement in amyotrophic lateral sclerosis: a study with tractography and diffusion-tensor imaging. Amyotroph Lateral Scler, 2009; 10: 288-294.
  7. Morozumi S, Kawagashira Y, Iijima M, Koike H, Hattori N, Katsuno M, Tanaka F, Sobue G. Intravenous immunoglobulin treatment for painful sensory neuropathy associated with Sjogren's syndrome. J Neurol Sci, 2009; 279: 57-61.
  8. Kondo N, Ito Y, Kawai M, Suzuki J, Tsuji H, Nishida S, Yasuda T, Sobue G. Obstructive sleep apnea syndrome (OSAS) presenting as cerebral venous thrombosis. Intern Med, 2009; 48: 1837-1840.
  9. Koike H, Morozumi S, Kawagashira Y, Iijima M, Yamamoto M, Hattori N, Tanaka F, Nakamura T, Hirayama M, Ando Y, Ikeda S, Sobue G. The significance of carpal tunnel syndrome in transthyretin Val30Met familial amyloid polyneuropathy. Amyloid, 2009; 16: 142-148.
  10. Koike H, Ando Y, Ueda M, Kawagashira Y, Iijima M, Fujitake J, Hayashi M, Yamamoto M, Mukai E, Nakamura T, Katsuno M, Hattori N, Sobue G. Distinct characteristics of amyloid deposits in early- and late-onset transthyretin Val30Met familial amyloid polyneuropathy. J Neurol Sci, 2009; 287: 178-184.
  11. Kawai Y, Suenaga M, Watanabe H, Sobue G. Cognitive impairment in spinocerebellar degeneration. Eur Neurol, 2009; 61: 257-268.
  12. Kawagashira Y, Watanabe H, Oki Y, Iijima M, Koike H, Hattori N, Katsuno M, Tanaka F, Sobue G. Intravenous immunoglobulin therapy in proximal diabetic neuropathy. BMJ Case Rep, 2009; 2009.
  13. Katsuno M, Banno H, Suzuki K, Adachi H, Tanaka F, Sobue G. [Molecular-targeted therapies for spinal and bulbar muscular atrophy]. Rinsho Shinkeigaku, 2009; 49: 917-920.
  14. Katsuno M, Adachi H, Sobue G. Getting a handle on Huntington's disease: the case for cholesterol. Nat Med, 2009; 15: 253-254.
  15. Iwasaki Y, Kizawa M, Hori N, Kitamoto T, Sobue G. A case of Gerstmann-Straussler-Scheinker syndrome with the P105L prion protein gene mutation presenting with ataxia and extrapyramidal signs without spastic paraparesis. Clin Neurol Neurosurg, 2009; 111: 606-609.
  16. Iijima M, Tomita M, Morozumi S, Kawagashira Y, Nakamura T, Koike H, Katsuno M, Hattori N, Tanaka F, Yamamoto M, Sobue G. Single nucleotide polymorphism of TAG-1 influences IVIg responsiveness of Japanese patients with CIDP. Neurology, 2009; 73: 1348-1352.
  17. Iguchi Y, Mori K, Koike H, Mano K, Goto Y, Kato T, Nakano T, Sobue G. Hypophosphataemic neuropathy during total parenteral nutrition. BMJ Case Rep, 2009; 2009.
  18. Iguchi Y, Katsuno M, Niwa J, Yamada S, Sone J, Waza M, Adachi H, Tanaka F, Nagata K, Arimura N, Watanabe T, Kaibuchi K, Sobue G. TDP-43 depletion induces neuronal cell damage through dysregulation of Rho family GTPases. J Biol Chem, 2009; 284: 22059-22066.
  19. Hama T, Iwasaki Y, Niwa H, Yoshida M, Hashizume Y, Kitamoto T, Murakami N, Sobue G. An autopsied case of panencephalopathic-type Creutzfeldt-Jakob disease with mutation in the prion protein gene at codon 232 and type 1 prion protein. Neuropathology, 2009; 29: 727-734.
  20. Goto A, Okuda S, Ito S, Matsuoka Y, Ito E, Takahashi A, Sobue G. Locomotion outcome in hemiplegic patients with middle cerebral artery infarction: the difference between right- and left-sided lesions. J Stroke Cerebrovasc Dis, 2009; 18: 60-67.
  21. Fujioka Y, Yasui K, Hasegawa Y, Takahashi A, Sobue G. [An acute severe heat stroke patient showing abnormal diffuse high intensity of the cerebellar cortex in diffusion weighted image: a case report]. Rinsho Shinkeigaku, 2009; 49: 634-640.
  22. Banno H, Katsuno M, Suzuki K, Tanaka F, Sobue G. Neuropathology and therapeutic intervention in spinal and bulbar muscular atrophy. Int J Mol Sci, 2009; 10: 1000-1012.
  23. Banno H, Katsuno M, Suzuki K, Takeuchi Y, Kawashima M, Suga N, Takamori M, Ito M, Nakamura T, Matsuo K, Yamada S, Oki Y, Adachi H, Minamiyama M, Waza M, Atsuta N, Watanabe H, Fujimoto Y, Nakashima T, Tanaka F, Doyu M, Sobue G. Phase 2 trial of leuprorelin in patients with spinal and bulbar muscular atrophy. Ann Neurol, 2009; 65: 140-150.
  24. Banno H, Katsuno M, Suzuki K, Iguchi Y, Adachi H, Tanaka F, Sobue G. [Molecular-targeted therapy for motor neuron disease]. Brain Nerve, 2009; 61: 891-900.
  25. Atsuta N, Watanabe H, Ito M, Tanaka F, Tamakoshi A, Nakano I, Aoki M, Tsuji S, Yuasa T, Takano H, Hayashi H, Kuzuhara S, Sobue G. Age at onset influences on wide-ranged clinical features of sporadic amyotrophic lateral sclerosis. J Neurol Sci, 2009; 276: 163-169.
  26. Adachi H, Katsuno M, Waza M, Minamiyama M, Tanaka F, Sobue G. Heat shock proteins in neurodegenerative diseases: pathogenic roles and therapeutic implications. Int J Hyperthermia, 2009; 25: 647-654.
2008
  1. Yamamoto M, Tanaka F, Tatsumi H, Sobue G. A strategy for developing effective amyotropic lateral sclerosis pharmacotherapy: from clinical trials to novel pharmacotherapeutic strategies. Expert Opin Pharmacother, 2008; 9: 1845-1857.
  2. Umemura T, Kawamura T, Sakakibara T, Kanai A, Sano T, Hotta N, Sobue G. Association of soluble adhesion molecule and C-reactive protein levels with silent brain infarction in patients with and without type 2 diabetes. Curr Neurovasc Res, 2008; 5: 106-111.
  3. Tanaka F, Waza M, Niwa J, Yamamoto M, Sobue G. [Exploration of pathogenesis-associated molecules and development of disease models for sporadic ALS]. Rinsho Shinkeigaku, 2008; 48: 970-972.
  4. Takeuchi Y, Katsuno M, Banno H, Suzuki K, Kawashima M, Atsuta N, Ito M, Watanabe H, Tanaka F, Sobue G. Walking capacity evaluated by the 6-minute walk test in spinal and bulbar muscular atrophy. Muscle Nerve, 2008; 38: 964-971.
  5. Suzuki K, Katsuno M, Banno H, Takeuchi Y, Atsuta N, Ito M, Watanabe H, Yamashita F, Hori N, Nakamura T, Hirayama M, Tanaka F, Sobue G. CAG repeat size correlates to electrophysiological motor and sensory phenotypes in SBMA. Brain, 2008; 131: 229-239.
  6. Suenaga M, Kawai Y, Watanabe H, Atsuta N, Ito M, Tanaka F, Katsuno M, Fukatsu H, Naganawa S, Sobue G. Cognitive impairment in spinocerebellar ataxia type 6. J Neurol Neurosurg Psychiatry, 2008; 79: 496-499.
  7. Niimi Y, Iwasaki Y, Umemura T, Tanaka F, Yoshida M, Hashizume Y, Kitamoto T, Hirayama M, Sobue G. MM2-cortical-type sporadic Creutzfeldt-Jakob disease with early stage cerebral cortical pathology presenting with a rapidly progressive clinical course. Neuropathology, 2008; 28: 645-651.
  8. Koike H, Sobue G. Small neurons may be preferentially affected in ganglionopathy. J Neurol Neurosurg Psychiatry, 2008; 79: 113.
  9. Koike H, Kawagashira Y, Iijima M, Yamamoto M, Hattori N, Tanaka F, Hirayama M, Ando Y, Ikeda S, Sobue G. Electrophysiological features of late-onset transthyretin Met30 familial amyloid polyneuropathy unrelated to endemic foci. J Neurol, 2008; 255: 1526-1533.
  10. Koike H, Ito S, Morozumi S, Kawagashira Y, Iijima M, Hattori N, Tanaka F, Sobue G. Rapidly developing weakness mimicking Guillain-Barre syndrome in beriberi neuropathy: two case reports. Nutrition, 2008; 24: 776-780.
  11. Koike H, Iijima M, Mori K, Yamamoto M, Hattori N, Watanabe H, Tanaka F, Doyu M, Sobue G. Neuropathic pain correlates with myelinated fibre loss and cytokine profile in POEMS syndrome. J Neurol Neurosurg Psychiatry, 2008; 79: 1171-1179.
  12. Kawai Y, Suenaga M, Watanabe H, Ito M, Kato K, Kato T, Ito K, Tanaka F, Sobue G. Prefrontal hypoperfusion and cognitive dysfunction correlates in spinocerebellar ataxia type 6. J Neurol Sci, 2008; 271: 68-74.
  13. Kawai Y, Suenaga M, Takeda A, Ito M, Watanabe H, Tanaka F, Kato K, Fukatsu H, Naganawa S, Kato T, Ito K, Sobue G. Cognitive impairments in multiple system atrophy: MSA-C vs MSA-P. Neurology, 2008; 70: 1390-1396.
  14. Katsuno M, Banno H, Suzuki K, Takeuchi Y, Kawashima M, Tanaka F, Adachi H, Sobue G. Molecular genetics and biomarkers of polyglutamine diseases. Curr Mol Med, 2008; 8: 221-234.
  15. Iwasaki Y, Mimuro M, Yoshida M, Hashizume Y, Kitamoto T, Sobue G. Clinicopathologic characteristics of five autopsied cases of dura mater-associated Creutzfeldt-Jakob disease. Neuropathology, 2008; 28: 51-61.
  16. Ito M, Watanabe H, Atsuta N, Senda J, Kawai Y, Tanaka F, Naganawa S, Fukatsu H, Sobue G. Fractional anisotropy values detect pyramidal tract involvement in multiple system atrophy. J Neurol Sci, 2008; 271: 40-46.
  17. Iijima M, Koike H, Hattori N, Tamakoshi A, Katsuno M, Tanaka F, Yamamoto M, Arimura K, Sobue G. Prevalence and incidence rates of chronic inflammatory demyelinating polyneuropathy in the Japanese population. J Neurol Neurosurg Psychiatry, 2008; 79: 1040-1043.
  18. Hori N, Takamori M, Hirayama M, Watanabe H, Nakamura T, Yamashita F, Ito H, Mabuchi N, Sobue G. Pupillary supersensitivity and visual disturbance in Parkinson's disease. Clin Auton Res, 2008; 18: 20-27.
  19. Hirayama M, Nakamura T, Hori N, Koike Y, Sobue G. The video images of sleep attacks in Parkinson's disease. Mov Disord, 2008; 23: 288-290.
  20. Hattori N, Koike H, Sobue G. [Metabolic and nutritional neuropathy]. Rinsho Shinkeigaku, 2008; 48: 1026-1027.
  21. Doi H, Niimi Y, Hasegawa Y, Miwa S, Yamana T, Takagi S, Takahashi A, Sobue G. [Relationship between cardiac 123I-metaiodobenzylguanidine scintigraphy and cardiovascular autonomic function test (standing test) in Parkinson's disease]. Rinsho Shinkeigaku, 2008; 48: 56-59.
2007
  1. Yamamoto M, Tanaka F, Sobue G. [Gene expression profile of spinal ventral horn in ALS]. Brain Nerve, 2007; 59: 1129-1139.
  2. Tanaka F, Sobue G. [Integrated molecular medicine for neuronal and neoplastic disorders]. Seikagaku, 2007; 79: 121-130.
  3. Takamori M, Hirayama M, Kobayashi R, Ito H, Mabuchi N, Nakamura T, Hori N, Koike Y, Sobue G. Altered venous capacitance as a cause of postprandial hypotension in multiple system atrophy. Clin Auton Res, 2007; 17: 20-25.
  4. Sobue G. Scientific highlights. 17th International Symposium on ALS/MND Yokohama, Japan, November 30, 2006 through December 2, 2006. Amyotroph Lateral Scler, 2007; 8: 121-123.
  5. Sobue G. [Animal models of neurodegenerative diseases on the road to disease-modifying therapy: spinal and bulbar muscular atrophy]. Rinsho Shinkeigaku, 2007; 47: 941-943.
  6. Oki Y, Koike H, Sobue G. [Adverse effects of therapeutic drugs on peripheral nervous system]. Nihon Naika Gakkai Zasshi, 2007; 96: 1591-1597.
  7. Oki Y, Koike H, Iijima M, Mori K, Hattori N, Katsuno M, Nakamura T, Hirayama M, Tanaka F, Shiraishi M, Yazaki S, Nokura K, Yamamoto H, Sobue G. Ataxic vs painful form of paraneoplastic neuropathy. Neurology, 2007; 69: 564-572.
  8. Niwa J, Yamada S, Ishigaki S, Sone J, Takahashi M, Katsuno M, Tanaka F, Doyu M, Sobue G. Disulfide bond mediates aggregation, toxicity, and ubiquitylation of familial amyotrophic lateral sclerosis-linked mutant SOD1. J Biol Chem, 2007; 282: 28087-28095.
  9. Nishibayashi M, Kokubun N, Nakamura A, Hirata K, Yamamoto M, Sobue G. [Distal hereditary motor neuropathy type II with mutation in heat shock protein 27 gene. A case report]. Rinsho Shinkeigaku, 2007; 47: 50-52.
  10. Nakamura T, Hirayama M, Ito H, Takamori M, Hamada K, Takeuchi S, Watanabe H, Koike Y, Sobue G. Dobutamine stress test unmasks cardiac sympathetic denervation in Parkinson's disease. J Neurol Sci, 2007; 263: 133-138.
  11. Koike H, Iijima M, Mori K, Yamamoto M, Hattori N, Katsuno M, Tanaka F, Watanabe H, Doyu M, Yoshikawa H, Sobue G. Nonmyelinating Schwann cell involvement with well-preserved unmyelinated axons in Charcot-Marie-Tooth disease type 1A. J Neuropathol Exp Neurol, 2007; 66: 1027-1036.
  12. Kawagashira Y, Watanabe H, Oki Y, Iijima M, Koike H, Hattori N, Katsuno M, Tanaka F, Sobue G. Intravenous immunoglobulin therapy markedly ameliorates muscle weakness and severe pain in proximal diabetic neuropathy. J Neurol Neurosurg Psychiatry, 2007; 78: 899-901.
  13. Katsuno M, Banno H, Suzuki K, Takeuchi Y, Sobue G. [Paradigm shift in clinical trials for neurodegenerative diseases]. Brain Nerve, 2007; 59: 367-374.
  14. Jiang YM, Yamamoto M, Tanaka F, Ishigaki S, Katsuno M, Adachi H, Niwa J, Doyu M, Yoshida M, Hashizume Y, Sobue G. Gene expressions specifically detected in motor neurons (dynactin 1, early growth response 3, acetyl-CoA transporter, death receptor 5, and cyclin C) differentially correlate to pathologic markers in sporadic amyotrophic lateral sclerosis. J Neuropathol Exp Neurol, 2007; 66: 617-627.
  15. Iwasaki Y, Yoshida M, Hashizume Y, Kitamoto T, Sobue G. Pyramidal tract degeneration in sporadic Creutzfeldt-Jakob disease. Neuropathology, 2007; 27: 434-441.
  16. Iwasaki Y, Yoshida M, Hashizume Y, Hattori M, Aiba I, Sobue G. Widespread spinal cord involvement in progressive supranuclear palsy. Neuropathology, 2007; 27: 331-340.
  17. Iwasaki Y, Mimuro M, Yoshida M, Hashizume Y, Ito M, Kitamoto T, Wakayama Y, Sobue G. Enhanced Aquaporin-4 immunoreactivity in sporadic Creutzfeldt-Jakob disease. Neuropathology, 2007; 27: 314-323.
  18. Ito M, Watanabe H, Kawai Y, Atsuta N, Tanaka F, Naganawa S, Fukatsu H, Sobue G. Usefulness of combined fractional anisotropy and apparent diffusion coefficient values for detection of involvement in multiple system atrophy. J Neurol Neurosurg Psychiatry, 2007; 78: 722-728.
  19. Ishigaki S, Niwa J, Yamada S, Takahashi M, Ito T, Sone J, Doyu M, Urano F, Sobue G. Dorfin-CHIP chimeric proteins potently ubiquitylate and degrade familial ALS-related mutant SOD1 proteins and reduce their cellular toxicity. Neurobiol Dis, 2007; 25: 331-341.
  20. Iguchi Y, Mori K, Koike H, Mano K, Goto Y, Kato T, Nakano T, Furukawa D, Sobue G. Hypophosphataemic neuropathy in a patient who received intravenous hyperalimentation. J Neurol Neurosurg Psychiatry, 2007; 78: 1159-1160.
  21. Adachi H, Waza M, Tokui K, Katsuno M, Minamiyama M, Tanaka F, Doyu M, Sobue G. CHIP overexpression reduces mutant androgen receptor protein and ameliorates phenotypes of the spinal and bulbar muscular atrophy transgenic mouse model. J Neurosci, 2007; 27: 5115-5126.
  22. Adachi H, Waza M, Katsuno M, Tanaka F, Doyu M, Sobue G. Pathogenesis and molecular targeted therapy of spinal and bulbar muscular atrophy. Neuropathol Appl Neurobiol, 2007; 33: 135-151.
2006
  1. Yamada S, Niwa J, Ishigaki S, Takahashi M, Ito T, Sone J, Doyu M, Sobue G. Archaeal proteasomes effectively degrade aggregation-prone proteins and reduce cellular toxicities in mammalian cells. J Biol Chem, 2006; 281: 23842-23851.
  2. Waza M, Adachi H, Katsuno M, Minamiyama M, Tanaka F, Sobue G. Alleviating neurodegeneration by an anticancer agent: an Hsp90 inhibitor (17-AAG). Ann N Y Acad Sci, 2006; 1086: 21-34.
  3. Waza M, Adachi H, Katsuno M, Minamiyama M, Tanaka F, Doyu M, Sobue G. Modulation of Hsp90 function in neurodegenerative disorders: a molecular-targeted therapy against disease-causing protein. J Mol Med (Berl), 2006; 84: 635-646.
  4. Terao S, Miura N, Osano Y, Adachi K, Sobue G. [Clinical characteristics of elderly Japanese patients with amyotrophic lateral sclerosis; with special reference to the development of respiratory failure]. Rinsho Shinkeigaku, 2006; 46: 381-389.
  5. Terao S, Miura N, Noda A, Yoshida M, Hashizume Y, Ikeda H, Sobue G. Respiratory failure in a patient with antecedent poliomyelitis: amyotrophic lateral sclerosis or post-polio syndrome? Clin Neurol Neurosurg, 2006; 108: 670-674.
  6. Tanaka F, Niwa J, Ishigaki S, Katsuno M, Waza M, Yamamoto M, Doyu M, Sobue G. Gene expression profiling toward understanding of ALS pathogenesis. Ann N Y Acad Sci, 2006; 1086: 1-10.
  7. Sugiura M, Koike H, Iijima M, Mori K, Hattori N, Katsuno M, Tanaka F, Sobue G. Clinicopathologic features of nonsystemic vasculitic neuropathy and microscopic polyangiitis-associated neuropathy: a comparative study. J Neurol Sci, 2006; 241: 31-37.
  8. Niwa J, Sobue G. [Motor neuron disease and ubiquitin-proteasome system dysfunction]. Tanpakushitsu Kakusan Koso, 2006; 51: 1423-1427.
  9. Koike H, Watanabe H, Inukai A, Iijima M, Mori K, Hattori N, Sobue G. Myopathy in thiamine deficiency: analysis of a case. J Neurol Sci, 2006; 249: 175-179.
  10. Koike H, Sobue G. Alcoholic neuropathy. Curr Opin Neurol, 2006; 19: 481-486.
  11. Kizawa M, Mori K, Iijima M, Koike H, Hattori N, Sobue G. Intravenous immunoglobulin treatment in painful sensory neuropathy without sensory ataxia associated with Sjogren's syndrome. J Neurol Neurosurg Psychiatry, 2006; 77: 967-969.
  12. Katsuno M, Adachi H, Waza M, Banno H, Suzuki K, Tanaka F, Doyu M, Sobue G. Pathogenesis, animal models and therapeutics in spinal and bulbar muscular atrophy (SBMA). Exp Neurol, 2006; 200: 8-18.
  13. Katsuno M, Adachi H, Minamiyama M, Waza M, Tokui K, Banno H, Suzuki K, Onoda Y, Tanaka F, Doyu M, Sobue G. Reversible disruption of dynactin 1-mediated retrograde axonal transport in polyglutamine-induced motor neuron degeneration. J Neurosci, 2006; 26: 12106-12117.
  14. Iwasaki Y, Yoshida M, Hashizume Y, Kitamoto T, Sobue G. Clinicopathologic characteristics of sporadic Japanese Creutzfeldt-Jakob disease classified according to prion protein gene polymorphism and prion protein type. Acta Neuropathol, 2006; 112: 561-571.
  15. Iwasaki Y, Iijima M, Kimura S, Yoshida M, Hashizume Y, Yamada M, Kitamoto T, Sobue G. Autopsy case of sporadic Creutzfeldt-Jakob disease presenting with signs suggestive of brainstem and spinal cord involvement. Neuropathology, 2006; 26: 550-556.
  16. Banno H, Adachi H, Katsuno M, Suzuki K, Atsuta N, Watanabe H, Tanaka F, Doyu M, Sobue G. Mutant androgen receptor accumulation in spinal and bulbar muscular atrophy scrotal skin: a pathogenic marker. Ann Neurol, 2006; 59: 520-526.
  17. Atsuta N, Watanabe H, Ito M, Banno H, Suzuki K, Katsuno M, Tanaka F, Tamakoshi A, Sobue G. Natural history of spinal and bulbar muscular atrophy (SBMA): a study of 223 Japanese patients. Brain, 2006; 129: 1446-1455.
2005
  1. Yamamoto M, Ishigaki S, Katsuno M, Sobue G. [Motor neuron disease up-to date]. No To Shinkei, 2005; 57: 273-283.
  2. Yamada S, Mori K, Matsuo K, Inukai A, Kawagashira Y, Sobue G. Interferon alfa treatment for Sjogren's syndrome associated neuropathy. J Neurol Neurosurg Psychiatry, 2005; 76: 576-578.
  3. Waza M, Adachi H, Katsuno M, Minamiyama M, Sang C, Tanaka F, Inukai A, Doyu M, Sobue G. 17-AAG, an Hsp90 inhibitor, ameliorates polyglutamine-mediated motor neuron degeneration. Nat Med, 2005; 11: 1088-1095.
  4. Terao S, Miura N, Osano Y, Takatsu S, Adachi K, Noda A, Sobue G. Multiple cerebellar infarcts: clinical and pathophysiologic features. J Stroke Cerebrovasc Dis, 2005; 14: 193-198.
  5. Sone M, Yoshida M, Hashizume Y, Hishikawa N, Sobue G. alpha-Synuclein-immunoreactive structure formation is enhanced in sympathetic ganglia of patients with multiple system atrophy. Acta Neuropathol, 2005; 110: 19-26.
  6. Sone J, Hishikawa N, Koike H, Hattori N, Hirayama M, Nagamatsu M, Yamamoto M, Tanaka F, Yoshida M, Hashizume Y, Imamura H, Yamada E, Sobue G. Neuronal intranuclear hyaline inclusion disease showing motor-sensory and autonomic neuropathy. Neurology, 2005; 65: 1538-1543.
  7. Sobue G. [Pathogenesis and treatment of CIDP]. Rinsho Shinkeigaku, 2005; 45: 963-965.
  8. Nakamura T, Watanabe H, Hirayama M, Inukai A, Kabasawa H, Matsubara M, Mitake S, Nakamura M, Ando Y, Uchino M, Sobue G. CADASIL with NOTCH3 S180C presenting anticipation of onset age and hallucinations. J Neurol Sci, 2005; 238: 87-91.
  9. Mori K, Iijima M, Koike H, Hattori N, Tanaka F, Watanabe H, Katsuno M, Fujita A, Aiba I, Ogata A, Saito T, Asakura K, Yoshida M, Hirayama M, Sobue G. The wide spectrum of clinical manifestations in Sjogren's syndrome-associated neuropathy. Brain, 2005; 128: 2518-2534.
  10. Mabuchi N, Hirayama M, Koike Y, Watanabe H, Ito H, Kobayashi R, Hamada K, Sobue G. Progression and prognosis in pure autonomic failure (PAF): comparison with multiple system atrophy. J Neurol Neurosurg Psychiatry, 2005; 76: 947-952.
  11. Koike H, Hirayama M, Yamamoto M, Ito H, Hattori N, Umehara F, Arimura K, Ikeda S, Ando Y, Nakazato M, Kaji R, Hayasaka K, Nakagawa M, Sakoda S, Matsumura K, Onodera O, Baba M, Yasuda H, Saito T, Kira J, Nakashima K, Oka N, Sobue G. Age associated axonal features in HNPP with 17p11.2 deletion in Japan. J Neurol Neurosurg Psychiatry, 2005; 76: 1109-1114.
  12. Katsuno M, Sang C, Adachi H, Minamiyama M, Waza M, Tanaka F, Doyu M, Sobue G. Pharmacological induction of heat-shock proteins alleviates polyglutamine-mediated motor neuron disease. Proc Natl Acad Sci U S A, 2005; 102: 16801-16806.
  13. Jiang YM, Yamamoto M, Kobayashi Y, Yoshihara T, Liang Y, Terao S, Takeuchi H, Ishigaki S, Katsuno M, Adachi H, Niwa J, Tanaka F, Doyu M, Yoshida M, Hashizume Y, Sobue G. Gene expression profile of spinal motor neurons in sporadic amyotrophic lateral sclerosis. Ann Neurol, 2005; 57: 236-251.
  14. Iwasaki Y, Yoshida M, Hattori M, Hashizume Y, Sobue G. Widespread spinal cord involvement in corticobasal degeneration. Acta Neuropathol, 2005; 109: 632-638.
  15. Iwasaki Y, Yoshida M, Hashizume Y, Kitamoto T, Sobue G. Neuropathologic characteristics of spinal cord lesions in sporadic Creutzfeldt-Jakob disease. Acta Neuropathol, 2005; 110: 490-500.
  16. Iwasaki Y, Hashizume Y, Yoshida M, Kitamoto T, Sobue G. Neuropathologic characteristics of brainstem lesions in sporadic Creutzfeldt-Jakob disease. Acta Neuropathol, 2005; 109: 557-566.
  17. Ito M, Atsuta N, Watanabe H, Hirayama M, Sobue G. [The efficacy of olanzapine for delusion in patients with Parkinson's disease]. No To Shinkei, 2005; 57: 491-494.
  18. Iijima M, Yamamoto M, Hirayama M, Tanaka F, Katsuno M, Mori K, Koike H, Hattori N, Arimura K, Nakagawa M, Yoshikawa H, Hayasaka K, Onodera O, Baba M, Yasuda H, Saito T, Nakazato M, Nakashima K, Kira J, Kaji R, Oka N, Sobue G. Clinical and electrophysiologic correlates of IVIg responsiveness in CIDP. Neurology, 2005; 64: 1471-1475.
  19. Hishikawa N, Hashizume Y, Yoshida M, Niwa J, Tanaka F, Sobue G. Tuft-shaped astrocytes in Lewy body disease. Acta Neuropathol, 2005; 109: 373-380.
  20. Adachi H, Katsuno M, Minamiyama M, Waza M, Sang C, Nakagomi Y, Kobayashi Y, Tanaka F, Doyu M, Inukai A, Yoshida M, Hashizume Y, Sobue G. Widespread nuclear and cytoplasmic accumulation of mutant androgen receptor in SBMA patients. Brain, 2005; 128: 659-670.
2004
  1. Yamamoto M, Yoshihara T, Hattori N, Sobue G. Glu528del in NEFL is a polymorphic variant rather than a disease-causing mutation for Charcot-Marie-Tooth disease in Japan. Neurogenetics, 2004; 5: 75-77.
  2. Yamada S, Matsuo K, Hirayama M, Sobue G. The effects of levodopa on apraxia of lid opening: A case report. Neurology, 2004; 62: 830-831.
  3. Watanabe H, Takeda A, Kawai Y, Sobue G. [Cognitive impairment in patients with multiple system atrophy]. Nihon Rinsho, 2004; 62 Suppl: 127-131.
  4. Watanabe H, Fukatsu H, Katsuno M, Sugiura M, Hamada K, Okada Y, Hirayama M, Ishigaki T, Sobue G. Multiple regional 1H-MR spectroscopy in multiple system atrophy: NAA/Cr reduction in pontine base as a valuable diagnostic marker. J Neurol Neurosurg Psychiatry, 2004; 75: 103-109.
  5. Watanabe H, Fukatsu H, Hishikawa N, Hashizume Y, Sobue G. Field strengths and sequences influence putaminal MRI findings in multiple system atrophy. Neurology, 2004; 62: 671.
  6. Terao S, Miura N, Osano Y, Noda A, Sobue G. Rapidly progressive fatal respiratory failure (Ondine's curse) in the lateral medullary syndrome. J Stroke Cerebrovasc Dis, 2004; 13: 41-44.
  7. Takeuchi H, Niwa J, Hishikawa N, Ishigaki S, Tanaka F, Doyu M, Sobue G. Dorfin prevents cell death by reducing mitochondrial localizing mutant superoxide dismutase 1 in a neuronal cell model of familial amyotrophic lateral sclerosis. J Neurochem, 2004; 89: 64-72.
  8. Takeda A, Kawai Y, Sobue G. [Semantic dementia]. Nihon Rinsho, 2004; 62 Suppl: 167-170.
  9. Takeda A, Kawai Y, Hattori Y, Watanabe Y, Mizuno Y, Tabata O, Kawamura Y, Shibayama H, Sobue G. [Development of a brief communication ability scale for Japanese demented elderly]. Nihon Ronen Igakkai Zasshi, 2004; 41: 402-407.
  10. Sobue G. [Clinical description of neuropathies]. Nihon Naika Gakkai Zasshi, 2004; 93: 1971-1976.
  11. Niwa J, Sobue G. [Motor neuron disease]. Tanpakushitsu Kakusan Koso, 2004; 49: 1127-1128.
  12. Mitsuma N, Yamamoto M, Iijima M, Hattori N, Ito Y, Tanaka F, Sobue G. Wide range of lineages of cells expressing nerve growth factor mRNA in the nerve lesions of patients with vasculitic neuropathy: an implication of endoneurial macrophage for nerve regeneration. Neuroscience, 2004; 129: 109-117.
  13. Minamiyama M, Katsuno M, Adachi H, Waza M, Sang C, Kobayashi Y, Tanaka F, Doyu M, Inukai A, Sobue G. Sodium butyrate ameliorates phenotypic expression in a transgenic mouse model of spinal and bulbar muscular atrophy. Hum Mol Genet, 2004; 13: 1183-1192.
  14. Mabuchi N, Watanabe H, Atsuta N, Hirayama M, Ito H, Fukatsu H, Kato T, Ito K, Sobue G. Primary lateral sclerosis presenting parkinsonian symptoms without nigrostriatal involvement. J Neurol Neurosurg Psychiatry, 2004; 75: 1768-1771.
  15. Koike H, Misu K, Sugiura M, Iijima M, Mori K, Yamamoto M, Hattori N, Mukai E, Ando Y, Ikeda S, Sobue G. Pathology of early- vs late-onset TTR Met30 familial amyloid polyneuropathy. Neurology, 2004; 63: 129-138.
  16. Koike H, Iijima M, Mori K, Hattori N, Ito H, Hirayama M, Sobue G. Postgastrectomy polyneuropathy with thiamine deficiency is identical to beriberi neuropathy. Nutrition, 2004; 20: 961-966.
  17. Kawai Y, Takeda A, Abe Y, Washimi Y, Tanaka F, Sobue G. Cognitive impairments in Machado-Joseph disease. Arch Neurol, 2004; 61: 1757-1760.
  18. Katsuno M, Sobue G. Polyglutamine diminishes VEGF; passage to motor neuron death? Neuron, 2004; 41: 677-679.
  19. Katsuno M, Adachi H, Tanaka F, Sobue G. Spinal and bulbar muscular atrophy: ligand-dependent pathogenesis and therapeutic perspectives. J Mol Med (Berl), 2004; 82: 298-307.
  20. Katsuno M, Adachi H, Sobue G. Sweet relief for Huntington disease. Nat Med, 2004; 10: 123-124.
  21. Katsuno M, Adachi H, Hanno H, Sobue G. [Development of the treatment for bulbospinal muscular atrophy]. Nihon Naika Gakkai Zasshi, 2004; 93: 1466-1472.
  22. Iwasaki Y, Yoshida M, Hattori M, Goto A, Aiba I, Hashizume Y, Sobue G. Distribution of tuft-shaped astrocytes in the cerebral cortex in progressive supranuclear palsy. Acta Neuropathol, 2004; 108: 399-405.
  23. Iwasaki Y, Sawada K, Aiba I, Mukai E, Yoshida M, Hashizume Y, Sobue G. Widespread active inflammatory lesions in a case of HTLV-I-associated myelopathy lasting 29 years. Acta Neuropathol, 2004; 108: 546-551.
  24. Ishigaki S, Hishikawa N, Niwa J, Iemura S, Natsume T, Hori S, Kakizuka A, Tanaka K, Sobue G. Physical and functional interaction between Dorfin and Valosin-containing protein that are colocalized in ubiquitylated inclusions in neurodegenerative disorders. J Biol Chem, 2004; 279: 51376-51385.
  25. Adachi H, Katsuno M, Sobue G. [Treatment of spinal and bulbar muscular atrophy]. No To Shinkei, 2004; 56: 772-779.
2003
  1. Yamamoto M, Ito Y, Mitsuma N, Hattori N, Sobue G. Pain-related differential expression of NGF, GDNF, IL-6, and their receptors in human vasculitic neuropathies. Intern Med, 2003; 42: 1100-1103.
  2. Yamada T, Nakamura A, Horibe K, Washimi Y, Bundo M, Kato T, Ito K, Kachi T, Sobue G. Asymmetrical enhancement of middle-latency auditory evoked fields with aging. Neurosci Lett, 2003; 337: 21-24.
  3. Yamada S, Atsuta N, Motegi Y, Hashizume Y, Sobue G. [Successful early-stage corticosteroid treatment in a case of granulomatous angiitis of the central nervous system]. Rinsho Shinkeigaku, 2003; 43: 503-506.
  4. Watanabe H, Fukatsu H, Ito T, Iijima M, Mabuchi N, Sobue G. [Magnetic resonance spectroscopy and its clinical applications in multiple sclerosis]. Nihon Rinsho, 2003; 61: 1435-1441.
  5. Wada M, Kimura M, Daimon M, Kurita K, Kato T, Johmura Y, Johkura K, Kuroiwa Y, Sobue G. An unusual phenotype of McLeod syndrome with late onset axonal neuropathy. J Neurol Neurosurg Psychiatry, 2003; 74: 1697-1698.
  6. Sobue G. [Clinical phenotype of Charcot-Marie-Tooth disease (CMT) and familial amyloid polyneuropathy (FAP)]. Rinsho Shinkeigaku, 2003; 43: 769-774.
  7. Sobue G. [Development of therapeutics for spinal and bulbar muscular atrophy (SBMA)]. Rinsho Shinkeigaku, 2003; 43: 909-911.
  8. Niwa J, Sobue G. [Neurodegenerative diseases and Dorfin]. No To Shinkei, 2003; 55: 856-868.
  9. Mori K, Iijima M, Sugiura M, Koike H, Hattori N, Ito H, Hirayama M, Sobue G. Sjogren's syndrome associated painful sensory neuropathy without sensory ataxia. J Neurol Neurosurg Psychiatry, 2003; 74: 1320-1322.
  10. Kuru S, Inukai A, Kato T, Liang Y, Kimura S, Sobue G. Expression of tumor necrosis factor-alpha in regenerating muscle fibers in inflammatory and non-inflammatory myopathies. Acta Neuropathol, 2003; 105: 217-224.
  11. Koike H, Iijima M, Sugiura M, Mori K, Hattori N, Ito H, Hirayama M, Sobue G. Alcoholic neuropathy is clinicopathologically distinct from thiamine-deficiency neuropathy. Ann Neurol, 2003; 54: 19-29.
  12. Kobayashi R, Koike Y, Hirayama M, Ito H, Sobue G. Skin sympathetic nerve function during sleep--a study with effector responses. Auton Neurosci, 2003; 103: 121-126.
  13. Katsuno M, Adachi H, Inukai A, Sobue G. Transgenic mouse models of spinal and bulbar muscular atrophy (SBMA). Cytogenet Genome Res, 2003; 100: 243-251.
  14. Katsuno M, Adachi H, Doyu M, Minamiyama M, Sang C, Kobayashi Y, Inukai A, Sobue G. Leuprorelin rescues polyglutamine-dependent phenotypes in a transgenic mouse model of spinal and bulbar muscular atrophy. Nat Med, 2003; 9: 768-773.
  15. Ito Y, Kato T, Suzuki T, Yokokawa Y, Aiba I, Arahata Y, Ito E, Ito K, Yasuda T, Sobue G. Neuroradiologic and clinical abnormalities in dementia of diffuse neurofibrillary tangles with calcification (Kosaka-Shibayama disease). J Neurol Sci, 2003; 209: 105-109.
  16. Ito T, Niwa J, Hishikawa N, Ishigaki S, Doyu M, Sobue G. Dorfin localizes to Lewy bodies and ubiquitylates synphilin-1. J Biol Chem, 2003; 278: 29106-29114.
  17. Hishikawa N, Niwa J, Doyu M, Ito T, Ishigaki S, Hashizume Y, Sobue G. Dorfin localizes to the ubiquitylated inclusions in Parkinson's disease, dementia with Lewy bodies, multiple system atrophy, and amyotrophic lateral sclerosis. Am J Pathol, 2003; 163: 609-619.
  18. Hishikawa N, Hashizume Y, Yoshida M, Sobue G. Clinical and neuropathological correlates of Lewy body disease. Acta Neuropathol, 2003; 105: 341-350.
  19. Hishikawa N, Hashizume Y, Ujihira N, Okada Y, Yoshida M, Sobue G. Alpha-synuclein-positive structures in association with diffuse neurofibrillary tangles with calcification. Neuropathol Appl Neurobiol, 2003; 29: 280-287.
  20. Hirayama M, Fukatsu H, Watanabe H, Koike Y, Noda A, Ito H, Kobayashi R, Sobue G. Sequential constriction of upper airway and vocal cords in sleep apnoea of multiple system atrophy: low field magnetic resonance fluoroscopic study. J Neurol Neurosurg Psychiatry, 2003; 74: 642-645.
  21. Hattori N, Yamamoto M, Yoshihara T, Koike H, Nakagawa M, Yoshikawa H, Ohnishi A, Hayasaka K, Onodera O, Baba M, Yasuda H, Saito T, Nakashima K, Kira J, Kaji R, Oka N, Sobue G. Demyelinating and axonal features of Charcot-Marie-Tooth disease with mutations of myelin-related proteins (PMP22, MPZ and Cx32): a clinicopathological study of 205 Japanese patients. Brain, 2003; 126: 134-151.
  22. Hamada K, Hirayama M, Watanabe H, Kobayashi R, Ito H, Ieda T, Koike Y, Sobue G. Onset age and severity of motor impairment are associated with reduction of myocardial 123I-MIBG uptake in Parkinson's disease. J Neurol Neurosurg Psychiatry, 2003; 74: 423-426.
  23. Ando Y, Liang Y, Ishigaki S, Niwa J, Jiang Y, Kobayashi Y, Yamamoto M, Doyu M, Sobue G. Caspase-1 and -3 mRNAs are differentially upregulated in motor neurons and glial cells in mutant SOD1 transgenic mouse spinal cord: a study using laser microdissection and real-time RT-PCR. Neurochem Res, 2003; 28: 839-846.
  24. Adachi H, Katsuno M, Minamiyama M, Sang C, Pagoulatos G, Angelidis C, Kusakabe M, Yoshiki A, Kobayashi Y, Doyu M, Sobue G. Heat shock protein 70 chaperone overexpression ameliorates phenotypes of the spinal and bulbar muscular atrophy transgenic mouse model by reducing nuclear-localized mutant androgen receptor protein. J Neurosci, 2003; 23: 2203-2211.
  25. Abe Y, Kachi T, Kato T, Arahata Y, Yamada T, Washimi Y, Iwai K, Ito K, Yanagisawa N, Sobue G. Occipital hypoperfusion in Parkinson's disease without dementia: correlation to impaired cortical visual processing. J Neurol Neurosurg Psychiatry, 2003; 74: 419-422.
2002
  1. Yoshihara T, Yamamoto M, Hattori N, Misu K, Mori K, Koike H, Sobue G. Identification of novel sequence variants in the neurofilament-light gene in a Japanese population: analysis of Charcot-Marie-Tooth disease patients and normal individuals. J Peripher Nerv Syst, 2002; 7: 221-224.
  2. Yoshihara T, Ishigaki S, Yamamoto M, Liang Y, Niwa J, Takeuchi H, Doyu M, Sobue G. Differential expression of inflammation- and apoptosis-related genes in spinal cords of a mutant SOD1 transgenic mouse model of familial amyotrophic lateral sclerosis. J Neurochem, 2002; 80: 158-167.
  3. Yamamoto M, Ito Y, Mitsuma N, Li M, Hattori N, Sobue G. Parallel expression of neurotrophic factors and their receptors in chronic inflammatory demyelinating polyneuropathy. Muscle Nerve, 2002; 25: 601-604.
  4. Watanabe H, Saito Y, Terao S, Ando T, Kachi T, Mukai E, Aiba I, Abe Y, Tamakoshi A, Doyu M, Hirayama M, Sobue G. Progression and prognosis in multiple system atrophy: an analysis of 230 Japanese patients. Brain, 2002; 125: 1070-1083.
  5. Watanabe H, Misu K, Kobayashi T, Hattori N, Doyu M, Yokoyama I, Ando Y, Nakao A, Sobue G. ABO-incompatible auxiliary partial orthotopic liver transplant for late-onset familial amyloid polyneuropathy. J Neurol Sci, 2002; 195: 63-66.
  6. Takeuchi H, Kobayashi Y, Yoshihara T, Niwa J, Doyu M, Ohtsuka K, Sobue G. Hsp70 and Hsp40 improve neurite outgrowth and suppress intracytoplasmic aggregate formation in cultured neuronal cells expressing mutant SOD1. Brain Res, 2002; 949: 11-22.
  7. Takeuchi H, Kobayashi Y, Ishigaki S, Doyu M, Sobue G. Mitochondrial localization of mutant superoxide dismutase 1 triggers caspase-dependent cell death in a cellular model of familial amyotrophic lateral sclerosis. J Biol Chem, 2002; 277: 50966-50972.
  8. Sang C, Kobayashi Y, Du J, Katsumo M, Adachi H, Doyu M, Sobue G. c-Jun N-terminal kinase pathway mediates Lactacystin-induced cell death in a neuronal differentiated Neuro2a cell line. Brain Res Mol Brain Res, 2002; 108: 7-17.
  9. Niwa J, Ishigaki S, Hishikawa N, Yamamoto M, Doyu M, Murata S, Tanaka K, Taniguchi N, Sobue G. Dorfin ubiquitylates mutant SOD1 and prevents mutant SOD1-mediated neurotoxicity. J Biol Chem, 2002; 277: 36793-36798.
  10. Niwa H, Hayakawa K, Yamamoto M, Itoh T, Mitsuma T, Sobue G. Differential age-dependent trophic responses of nodose, sensory, and sympathetic neurons to neurotrophins and GDNF: potencies for neurite extension in explant culture. Neurochem Res, 2002; 27: 485-496.
  11. Mori K, Hattori N, Sugiura M, Koike H, Misu K, Ichimura M, Hirayama M, Sobue G. Chronic inflammatory demyelinating polyneuropathy presenting with features of GBS. Neurology, 2002; 58: 979-982.
  12. Mori K, Hattori N, Sobue G. [Clinical guideline review: Guillain-barre syndrome and chronic inflammatory demyelinating polyneuropathy]. Nihon Naika Gakkai Zasshi, 2002; 91: 2443-2457.
  13. Koike H, Misu K, Ikeda S, Ando Y, Nakazato M, Ando E, Yamamoto M, Hattori N, Sobue G. Type I (transthyretin Met30) familial amyloid polyneuropathy in Japan: early- vs late-onset form. Arch Neurol, 2002; 59: 1771-1776.
  14. Katsuno M, Ando T, Hakusui S, Yanagi T, Sobue G. Motor conduction studies in Miller Fisher syndrome with severe tetraparesis. Muscle Nerve, 2002; 25: 378-382.
  15. Katsuno M, Adachi H, Kume A, Li M, Nakagomi Y, Niwa H, Sang C, Kobayashi Y, Doyu M, Sobue G. Testosterone reduction prevents phenotypic expression in a transgenic mouse model of spinal and bulbar muscular atrophy. Neuron, 2002; 35: 843-854.
  16. Kato T, Indo T, Yoshida E, Iwasaki Y, Sone M, Sobue G. Contrast-enhanced 2D cine phase MR angiography for measurement of basilar artery blood flow in posterior circulation ischemia. AJNR Am J Neuroradiol, 2002; 23: 1346-1351.
  17. Iwai K, Yamamoto M, Yoshihara T, Sobue G. Anticipation in familial amyotrophic lateral sclerosis with SOD1-G93S mutation. J Neurol Neurosurg Psychiatry, 2002; 72: 819-820.
  18. Ishigaki S, Niwa J, Ando Y, Yoshihara T, Sawada K, Doyu M, Yamamoto M, Kato K, Yotsumoto Y, Sobue G. Differentially expressed genes in sporadic amyotrophic lateral sclerosis spinal cords--screening by molecular indexing and subsequent cDNA microarray analysis. FEBS Lett, 2002; 531: 354-358.
  19. Ishigaki S, Liang Y, Yamamoto M, Niwa J, Ando Y, Yoshihara T, Takeuchi H, Doyu M, Sobue G. X-Linked inhibitor of apoptosis protein is involved in mutant SOD1-mediated neuronal degeneration. J Neurochem, 2002; 82: 576-584.
  20. Ikeda S, Nakazato M, Ando Y, Sobue G. Familial transthyretin-type amyloid polyneuropathy in Japan: clinical and genetic heterogeneity. Neurology, 2002; 58: 1001-1007.
  21. Hattori N, Mori K, Misu K, Koike H, Ichimura M, Sobue G. Mortality and morbidity in peripheral neuropathy associated Churg-Strauss syndrome and microscopic polyangiitis. J Rheumatol, 2002; 29: 1408-1414.
  22. Dei R, Takeda A, Niwa H, Li M, Nakagomi Y, Watanabe M, Inagaki T, Washimi Y, Yasuda Y, Horie K, Miyata T, Sobue G. Lipid peroxidation and advanced glycation end products in the brain in normal aging and in Alzheimer's disease. Acta Neuropathol, 2002; 104: 113-122.
2001
  1. Yoshihara T, Kanda F, Yamamoto M, Ishihara H, Misu K, Hattori N, Chihara K, Sobue G. A novel missense mutation in the early growth response 2 gene associated with late-onset Charcot--Marie--Tooth disease type 1. J Neurol Sci, 2001; 184: 149-153.
  2. Yamamoto M, Li M, Mitsuma N, Ito S, Kato M, Takahashi M, Sobue G. Preserved phosphorylation of RET receptor protein in spinal motor neurons of patients with amyotrophic lateral sclerosis: an immunohistochemical study by a phosphorylation-specific antibody at tyrosine 1062. Brain Res, 2001; 912: 89-94.
  3. Yamamoto M, Kobayashi Y, Li M, Niwa H, Mitsuma N, Ito Y, Muramatsu T, Sobue G. In vivo gene electroporation of glial cell line-derived neurotrophic factor (GDNF) into skeletal muscle of SOD1 mutant mice. Neurochem Res, 2001; 26: 1201-1207.
  4. Yamamoto M, Ito Y, Mitsuma N, Li M, Hattori N, Sobue G. Pathology-related differential expression regulation of NGF, GDNF, CNTF, and IL-6 mRNAs in human vasculitic neuropathy. Muscle Nerve, 2001; 24: 830-833.
  5. Watanabe H, Misu K, Hirayama M, Hattori N, Yoshihara T, Doyu M, Sobue G. Low cardiac 123I-MIBG uptake in late-onset familial amyloid polyneuropathy type I (TTR Met30). J Neurol, 2001; 248: 627-629.
  6. Watanabe H, Ieda T, Katayama T, Takeda A, Aiba I, Doyu M, Hirayama M, Sobue G. Cardiac (123)I-meta-iodobenzylguanidine (MIBG) uptake in dementia with Lewy bodies: comparison with Alzheimer's disease. J Neurol Neurosurg Psychiatry, 2001; 70: 781-783.
  7. Takeda A, Wakai M, Niwa H, Dei R, Yamamoto M, Li M, Goto Y, Yasuda T, Nakagomi Y, Watanabe M, Inagaki T, Yasuda Y, Miyata T, Sobue G. Neuronal and glial advanced glycation end product [Nepsilon-(carboxymethyl)lysine]] in Alzheimer's disease brains. Acta Neuropathol, 2001; 101: 27-35.
  8. Sobue G. [Physiopathology and treatment of neuropathies--recent progress]. Nihon Naika Gakkai Zasshi, 2001; 90: 461-464.
  9. Sobue G. [Molecular pathogenesis of motor neuron diseases]. Nihon Shinkei Seishin Yakurigaku Zasshi, 2001; 21: 21-25.
  10. Sobue G. [Molecular pathogenesis of motor neuron disease]. Rinsho Shinkeigaku, 2001; 41: 1070-1071.
  11. Niwa J, Ishigaki S, Doyu M, Suzuki T, Tanaka K, Sobue G. A novel centrosomal ring-finger protein, dorfin, mediates ubiquitin ligase activity. Biochem Biophys Res Commun, 2001; 281: 706-713.
  12. Nakai Y, Okumura A, Takada H, Negoro T, Watanabe K, Hattori N, Sobue G. Inflammatory pathological changes in a 2-year-old boy with Charcot-Marie-Tooth disease. Brain Dev, 2001; 23: 258-260.
  13. Mori K, Koike H, Misu K, Hattori N, Ichimura M, Sobue G. Spinal cord magnetic resonance imaging demonstrates sensory neuronal involvement and clinical severity in neuronopathy associated with Sjogren's syndrome. J Neurol Neurosurg Psychiatry, 2001; 71: 488-492.
  14. Koike H, Mori K, Misu K, Hattori N, Ito H, Hirayama M, Sobue G. Painful alcoholic polyneuropathy with predominant small-fiber loss and normal thiamine status. Neurology, 2001; 56: 1727-1732.
  15. Koike H, Misu K, Hattori N, Ito S, Ichimura M, Ito H, Hirayama M, Nagamatsu M, Sasaki I, Sobue G. Postgastrectomy polyneuropathy with thiamine deficiency. J Neurol Neurosurg Psychiatry, 2001; 71: 357-362.
  16. Kobayashi Y, Sobue G. Protective effect of chaperones on polyglutamine diseases. Brain Res Bull, 2001; 56: 165-168.
  17. Katsuno M, Ando T, Hakusui S, Yanagi T, Adachi Y, Sobue G. [A case of familial hypokalemic periodic paralysis with hyperuricemia during paralytic attack and genetic analysis of the pedigree]. Rinsho Shinkeigaku, 2001; 41: 397-401.
  18. Ito Y, Yamamoto M, Mitsuma N, Li M, Hattori N, Sobue G. Expression of mRNAs for ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), interleukin-6 (IL-6), and their receptors (CNTFR alpha, LIFR beta, IL-6R alpha, and gp130) in human peripheral neuropathies. Neurochem Res, 2001; 26: 51-58.
  19. Hishikawa N, Hashizume Y, Yoshida M, Sobue G. Widespread occurrence of argyrophilic glial inclusions in Parkinson's disease. Neuropathol Appl Neurobiol, 2001; 27: 362-372.
  20. Hattori N, Yamamoto M, Sobue G. [Inherited peripheral neuropathy]. Nihon Rinsho, 2001; 59 Suppl 8: 597-603.
  21. Hattori N, Misu K, Koike H, Ichimura M, Nagamatsu M, Hirayama M, Sobue G. Age of onset influences clinical features of chronic inflammatory demyelinating polyneuropathy. J Neurol Sci, 2001; 184: 57-63.
  22. Adachi H, Sobue G. [Understanding of polyglutamine diseases through transgenic mouse models]. No To Shinkei, 2001; 53: 839-845.
  23. Adachi H, Kume A, Li M, Nakagomi Y, Niwa H, Do J, Sang C, Kobayashi Y, Doyu M, Sobue G. Transgenic mice with an expanded CAG repeat controlled by the human AR promoter show polyglutamine nuclear inclusions and neuronal dysfunction without neuronal cell death. Hum Mol Genet, 2001; 10: 1039-1048.
2000
  1. Yoshihara T, Yamamoto M, Doyu M, Mis KI, Hattori N, Hasegawa Y, Mokuno K, Mitsuma T, Sobue G. Mutations in the peripheral myelin protein zero and connexin32 genes detected by non-isotopic RNase cleavage assay and their phenotypes in Japanese patients with Charcot-Marie-Tooth disease. Hum Mutat, 2000; 16: 177-178.
  2. Yasui K, Ito Y, Ando T, Yanagi T, Tsuzuki T, Yoshida M, Hashizume Y, Sobue G. [An autopsy case of bilateral carotid artery occlusion with repetitive epilepsy and brain atrophy in a senile patient]. No To Shinkei, 2000; 52: 79-88.
  3. Yasui K, Ishigaki S, Koike H, Ieda T, Yoshida M, Hashizume Y, Watanabe K, Sobue G. Correlation of magnetic resonance imaging findings and histopathology of lesion distribution of spinal cord sarcoidosis at post-mortem. Neuropathol Appl Neurobiol, 2000; 26: 481-487.
  4. Watanabe H, Tanaka F, Doyu M, Riku S, Yoshida M, Hashizume Y, Sobue G. Differential somatic CAG repeat instability in variable brain cell lineage in dentatorubral pallidoluysian atrophy (DRPLA): a laser-captured microdissection (LCM)-based analysis. Hum Genet, 2000; 107: 452-457.
  5. Watanabe H, Inukai A, Doyu M, Sobue G. [CNS cryptococcosis with idiopathic CD4+ T lymphocytopenia]. Rinsho Shinkeigaku, 2000; 40: 249-253.
  6. Watanabe H, Arahata Y, Tadokoro M, Kato T, Sobue G. [Effects of tandospirone citrate on frozen gait in patients with early stage of progressive supranuclear palsy, investigated by walk-induced activation single photon emission computed tomography method]. Rinsho Shinkeigaku, 2000; 40: 1130-1132.
  7. Terao S, Takeda A, Miura N, Izumi M, Ito E, Mitsuma T, Sobue G. Clinical and pathophysiological features of amaurosis fugax in Japanese stroke patients. Intern Med, 2000; 39: 118-122.
  8. Terao S, Osano Y, Fukuoka T, Miura N, Mitsuma T, Sobue G. Coexisting vertical and horizontal one and a half syndromes. J Neurol Neurosurg Psychiatry, 2000; 69: 401-402.
  9. Terao S, Miura N, Takeda A, Takahashi A, Mitsuma T, Sobue G. Course and distribution of facial corticobulbar tract fibres in the lower brain stem. J Neurol Neurosurg Psychiatry, 2000; 69: 262-265.
  10. Takeuchi H, Misu K, Hattori N, Nagamatsu M, Sobue G. Immunoglobulin therapy for idiopathic chronic sensory ataxic neuropathy. Neurology, 2000; 54: 1008-1010.
  11. Takano A, Bonnemann CG, Honda H, Sakai M, Feener CA, Kunkel LM, Sobue G. Intrafamilial phenotypic variation in limb-girdle muscular dystrophy type 2C with compound heterozygous mutations. Muscle Nerve, 2000; 23: 807-810.
  12. Sobue G. [Triplet repeat disease, with particular emphasis of spinal and bulbar muscular atrophy (SBMA)]. Rinsho Shinkeigaku, 2000; 40: 1193-1195.
  13. Mizuno K, Wakai M, Takeda A, Sobue G. Medial temporal atrophy and memory impairment in early stage of Alzheimer's disease: an MRI volumetric and memory assessment study. J Neurol Sci, 2000; 173: 18-24.
  14. Misu K, Yoshihara T, Yamamoto M, Hattori N, Nagamatu M, Mukai E, Takegami T, Sobue G. [Two families of Charcot-Marie-Tooth disease with Adie's pupil, axonal neuropahy and the Thr124Met mutation in the peripheral myelin protein zero gene]. Rinsho Shinkeigaku, 2000; 40: 149-154.
  15. Misu K, Yoshihara T, Shikama Y, Awaki E, Yamamoto M, Hattori N, Hirayama M, Takegami T, Nakashima K, Sobue G. An axonal form of Charcot-Marie-Tooth disease showing distinctive features in association with mutations in the peripheral myelin protein zero gene (Thr124Met or Asp75Val). J Neurol Neurosurg Psychiatry, 2000; 69: 806-811.
  16. Misu K, Hattori N, Ando Y, Ikeda S, Sobue G. Anticipation in early- but not late-onset familial amyloid polyneuropathy (TTR met 30) in Japan. Neurology, 2000; 55: 451-452.
  17. Liang Y, Inukai A, Kuru S, Kato T, Doyu M, Sobue G. The role of lymphotoxin in pathogenesis of polymyositis. Acta Neuropathol, 2000; 100: 521-527.
  18. Kuru S, Inukai A, Liang Y, Doyu M, Takano A, Sobue G. Tumor necrosis factor-alpha expression in muscles of polymyositis and dermatomyositis. Acta Neuropathol, 2000; 99: 585-588.
  19. Koike H, Sobue G. Crow-Fukase syndrome. Neuropathology, 2000; 20 Suppl: S69-72.
  20. Koike H, Misu K, Yasui K, Kameyama T, Ando T, Yanagi T, Sobue G. Differential response to corticosteroid therapy of MRI findings and clinical manifestations in spinal cord sarcoidosis. J Neurol, 2000; 247: 544-549.
  21. Kobayashi Y, Kume A, Li M, Doyu M, Hata M, Ohtsuka K, Sobue G. Chaperones Hsp70 and Hsp40 suppress aggregate formation and apoptosis in cultured neuronal cells expressing truncated androgen receptor protein with expanded polyglutamine tract. J Biol Chem, 2000; 275: 8772-8778.
  22. Kobari M, Irie J, Takizawa K, Yoshihara T, Sobue G. [X-Linked Charcot-Marie-Tooth disease with a new mutation (Thr191Ala) in the connexin32]. Rinsho Shinkeigaku, 2000; 40: 896-899.
  23. Kato T, Tanaka F, Yamamoto M, Yosida E, Indo T, Watanabe H, Yoshiwara T, Doyu M, Sobue G. Sisters homozygous for the spinocerebellar ataxia type 6 (SCA6)/CACNA1A gene associated with different clinical phenotypes. Clin Genet, 2000; 58: 69-73.
  24. Ito Y, Yamamoto M, Li M, Mitsuma N, Tanaka F, Doyu M, Suzumura A, Mitsuma T, Sobue G. Temporal expression of mRNAs for neuropoietic cytokines, interleukin-11 (IL-11), oncostatin M (OSM), cardiotrophin-1 (CT-1) and their receptors (IL-11Ralpha and OSMRbeta) in peripheral nerve injury. Neurochem Res, 2000; 25: 1113-1118.
  25. Ishigaki S, Niwa J, Yoshihara T, Mitsuma N, Doyu M, Sobue G. Two novel genes, human neugrin and mouse m-neugrin, are upregulated with neuronal differentiation in neuroblastoma cells. Biochem Biophys Res Commun, 2000; 279: 526-533.
  26. Inukai A, Kuru S, Liang Y, Takano A, Kobayashi Y, Sakai M, Doyu M, Sobue G. Expression of HLA-DR and its enhancing molecules in muscle fibers in polymyositis. Muscle Nerve, 2000; 23: 385-392.
  27. Inukai A, Doyu M, Kato T, Liang Y, Kuru S, Yamamoto M, Kobayashi Y, Sobue G. Reduced expression of DMAHP/SIX5 gene in myotonic dystrophy muscle. Muscle Nerve, 2000; 23: 1421-1426.
  28. Hishikawa N, Hashizume Y, Hirayama M, Imamura K, Washimi Y, Koike Y, Mabuchi C, Yoshida M, Sobue G. Brainstem-type Lewy body disease presenting with progressive autonomic failure and lethargy. Clin Auton Res, 2000; 10: 139-143.
  29. Hirayama M, Koike Y, Ieda T, Takahashi A, Sobue G. [A one-month combined use of selective adrenergic beta 1- and alpha 1-agonists for postprandial hypotension in patients with autonomic failure]. Rinsho Shinkeigaku, 2000; 40: 787-790.

MESSAGE

教室見学案内

名古屋大学神経内科学では、未来の脳神経内科医を目指す学生・研修医・若手医師を歓迎しています。実際に見学した方からは、「研究で活躍する医師の話を直接聞く事ができ、また症例検討会や神経診察を体験することで研究と臨床がつながるイメージがわいた」という声が多く寄せられています。

代表的なタイムスケジュール

9:00 医系研究棟1号館9階　神経内科学医局に集合、教授との面談
9:30 研究内容の紹介、外来や研究室の見学など
12:00 昼食
13:00 症例検討会
14:30 総回診

総回診を毎週火曜日に行っておりますため、火曜日にお越しいただくことを強くお勧めしています。病棟へ行く際に必要となりますため、白衣を持参ください。

午前中は、希望に応じて名古屋大学神経内科学医局やキャリアパスのご紹介をしたり、ベッドサイドで神経診察の魅力を直接体感することもできます。また、筋電図、神経伝導検査、自律神経機能検査などの電気生理検査、認知機能検査、特殊画像診断などの解説や見学もしていただけます。研究に興味のある方には、分子生物学的研究や動物実験施設の見学を通じて、研究チームのリーダーや若手研究者と直接対話できる機会もご用意できます。見学の申し込み時にあなただけのプランを考えますので、是非お気軽に御連絡ください。

入局について

名古屋大学神経内科医局では、神経内科に興味を持ち、ともに神経疾患に立ち向かってくれる若手医師の方を広く募集しています。神経内科に入局していただくことによって、長期的展望に立ち、みなさんの神経内科専門医取得にむけて医局として全面的にサポートします。さまざまな神経疾患に対する専門的資質を備えると同時に、多角的な視野を備えた神経内科専門医育成を実現するためには、専門医同士の連携・コミュニケーションが欠かせません。その過程が入局であると思います。勤務医を目指す医師にとっては豊富な関連病院から将来の職場を選択できます。開業を目指す医師にとっては470名近い同窓会の支援を受けることが可能です。研究志向の先生方には、分子生物学的な基礎研究、病理学的研究や臨床研究を共に推進していただける環境を、大学院博士課程への入学として積極的にサポートしています

大学院生募集

初期研修、後期研修で学んだ経験や知識を生かし、大学院4年間で大学病院ならではの希少疾患の診断、治療を行い、神経内科専門医としての技量向上を目指し、その中から自分に合ったサブスペシャリティーを見つけて研究します。大学院博士課程に入学することは、その後の神経内科専門医としてのキャリアにとても重要であると考えられます。多くの同年代の先生や在局の先生方と議論を深め、論理的考察ができるようになるからです。現在、大学院博士課程において十分に学べる環境を提供できる体制が整っています。

1年生

大学病院ならではの希少疾患を含め、広く神経疾患を専門医の指導の下、病棟主治医として担当します。大学病院には神経内科の中でも、さらに特殊なサブスペシャリティーをもった専門医が多数在籍しており、一般病院では経験できない検査やレベルの高い症例検討、治験なども含めた最先端の治療法を学ぶことができます。

2～4年生

大学院1年生の間に自分にあったサブスペシャリティーを見つけ、各研究グループに分かれ、教授およびグループ全体で研究テーマを考え、研究を行います。2～4年生の期間は研究に専念し、卒業と同時に学位を取得することを目指します。
毎年、6、7名[ID1.1]の大学院生を募集しています。入学希望のある先生は、所属の神経内科責任者を通じてご連絡ください。関連病院以外の先生で名大大学院へ入学希望の方は直接医局まで連絡ください。
大学院卒業後の進路として、

  • 大学で診療・研究を継続する
  • 海外への留学
  • 関連病院への赴任
  • その他

を選択します。

女性医師へのサポート

脳神経内科はライフイベントとキャリアの両立がしやすく、女性医師に人気の高い診療科の一つです。脳梗塞超急性期などの緊急性の高い診療から、慢性疾患のリハビリテーションや訪問診療など幅の広い働き方ができ、ライフスタイルに合わせた職場の選択をできることが魅力です。
また、脳神経内科は特殊な技術を必要とする診療が少なく、どちらかというと経験や知識を必要とする診療科であることから、妊娠・出産・育児などによりブランクができても、復帰しやすく、活躍しやすい診療科でもあります。ライフステージに合わせたキャリアプランを一緒に考えましょう。

名古屋大学神経内科学は、挑戦する人を全力で応援する医局です。「患者さんとの触れ合いを大切にしたい」「難病の患者さんに対して治療薬を届けたい」「わからない症状と諦められていた患者さんに対して適切な診断をして差し上げたい」——そう感じる方は、ぜひ一度見学にいらしてください。未来の仲間にお会いできる日を楽しみにしています。

神経内科学　オープンキャンパス

神経内科学　フロントライン【筋萎縮性側索硬化症】

神経内科学　フロントライン【レビー小体型認知症】

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