Department of Cancer Epidemiology
KEYWORDS
- Molecular epidemiology
HEAD
MATSUO Keitaro
Adjunct Professor
CONTACT
| kmatsuo◎aichi-cc.jp(Please send a message after replacing "◎" mark with "@" mark. ) |
OUTLINE
We aims to elucidate environmental, lifestyle, and genetic factors that influence cancer development and prognosis through epidemiological approaches, and to construct and socially implement evidence-based cancer prevention strategies.
Large-scale epidemiological data derived from cohort studies and case–control studies are utilized to quantitatively evaluate a wide range of cancer risk factors, including smoking, alcohol consumption, dietary habits, obesity, infectious agents, and socioeconomic factors. In addition, from the perspectives of molecular and integrative epidemiology, the field places strong emphasis on analyses that integrate epidemiological data with genome-centered multi-omics information.
Furthermore, particular importance is placed on translating research findings into practical applications, such as optimization of cancer screening programs, identification of high-risk populations, and proposal of personalized preventive interventions. Through collaboration with governmental agencies, medical institutions, and research organizations, the field contributes to the development and evaluation of effective cancer prevention policies and strategies.
RESEARCH PROJECTS
Molecular epidemiological research primarily based on case–control studies using the Hospital-based Epidemiologic Research Program at Aichi Cancer Center (HERPACC). The group also participates in the Breast Cancer Association Consortium, the Ovarian Cancer Association Consortium, and the International Lung Cancer Consortium.
Molecular epidemiological research based on the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study.
https://jmicc.com/
The group additionally participates in the Japan Cohort Consortium, the Japan Genome Cohort Network, and the Japan Molecular Epidemiology Consortium.
BIBLIOGRAPHY
2024
- Koyanagi YN, Nakatochi M, Namba S, Oze I, (中略), Brennan P, Matsuo K. Genetic architecture of alcohol consumption identified by a genotype-stratified GWAS and impact on esophageal cancer risk in Japanese people. Sci Adv 2024;10(4),eade2780
2023
- Usui Y, Taniyama Y, Endo M, Koyanagi YN, Kasugai Y, Oze I, Ito H, Imoto I, Tanaka T, Tajika M, Niwa Y, Iwasaki Y, Aoi T, Hakozaki N, Takata S, Suzuki K, Terao C, Hatakeyama M, Hirata M, Sugano K, Yoshida T, Kamatani Y, Nakagawa H, Matsuda K, Murakami Y, Spurdle AB, Matsuo K*, Momozawa Y*. Helicobacter pylori, Homologous-Recombination Genes, and Gastric Cancer. N Engl J Med. 2023 Mar 30;388(13):1181-1190. *equal contribution
2020
- Koyanagi YN, Suzuki E, Imoto I, Ito H, Matsuo K. Across-Site Differences in the Mechanism of Alcohol-Induced Digestive Tract Carcinogenesis: An Evaluation by Mediation Analysis. Cancer Res 2020;80: 1601-1610.
- Lin Y, Nakatochi M, Hosono Y, Ito H,（中略） Matsuo K. Genome-wide association meta-analysis identifies GP2 gene risk variants for pancreatic cancer. Nat Commun. 11:3175, 2020.
MESSAGE
For the graduate program, priority will be given to applicants who possess at least a basic level of knowledge and experience in epidemiology and public health, and who aim to pursue a career as professional epidemiologists.
