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原著論文

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  1. Masaki T, Habara M, Hanaki S, Sato Y, Tomiyasu H, Miki Y, Shimada M*: Calcineurin-mediated dephosphorylation enhances the stability and transactivation of c-Myc. Sci. Rep., 13, 13116, 2023. [Link]
  2. Masaki T, Habara M, Shibutani S, Hanaki S, Sato Y, Tomiyasu H, Shimada M*: Dephosphorylation of the EGFR protein by calcineurin at serine 1046/1047 enhances its stability. Biochem. Biophys. Res. Commun., 641, 84-92, 2023. [Link]
  3. Habara M, Sato Y, Goshima T, Sakurai M, Imai H, Shimizu H, Katayama Y, Hanaki S, Masaki T, Morimoto M, Nishikawa S, Toyama T, Shimada M*: FKBP52 and FKBP51 Differentially Regulate the Stability of Estrogen Receptor in Breast Cancer. PNAS, 119, e2110256119, 2022. [Link]
  4. Masaki T, Habara M, Sato Y, Goshima T, Maeda K, Hanaki S, Shimada M*: Calcineurin regulates the stability and activity of estrogen receptor α. PNAS, 118, e2114258118, 2021. [Link]
  5. Maeda K, Habara M, Kawaguchi M, Matsumoto H, Hanaki S, Masaki T, Sato Y, Matsuyama H, Kunieda K, Nakagawa H, Shimada M*: FKBP51 and FKBP52 regulate androgen receptor dimerization and proliferation in prostate cancer cells. Mol Oncol., 16, 940-956, 2021. [Link]
  6. Hanaki S, Habara M, Masaki T, Maeda K, Sato Y, Nakanishi M, Shimada M*: PP1 regulatory subunit NIPP1 regulates transcription of E2F1 target genes following DNA damage. Cancer Sci., 112, 2739-2752, 2021. [Link]
  7. Mikawa T, Shibata E, Shimada M, Ito K, Ito T, Kanda H, Takubo K, Lleonart ME, Inagaki N, Yokode M, Kondoh H*: Phosphoglycerate mutase cooperates with Chk1 kinase to regulate glycolysis. iScience, 23, 101306, 2020. [Link]
  8. Goshima T, Habara M, Maeda K, Hanaki S, Kato Y, Shimada M*: Calcineurin regulates cyclin D1 stability through dephosphorylation at T286. Sci. Rep., 9, 12779, 2019. [Link]
  9. Nishimura K, Johmura Y, Deguchi K, Jiang Z, Uchida KSK, Suzuki N, Shimada M, Chiba Y, Hirota T, Yoshimura SH, Kono K, Nakanishi M*: Cdk1-mediated DIAPH1 phosphorylation maintains metaphase cortical tension and inactivates the spindle assembly checkpoint at anaphase. Nat. Commun., 10, 981, 2019. [Link]
  10. Iwata T, Uchino T, Koyama A, Johmura Y, Koyama J, Saito T, Ishiguro S, Arikawa T, Komatsu S, Miyachi M, Sano T, Nakanishi M, Shimada M*: The G2 checkpoint inhibitor CBP-93872 increases the sensitivity of colorectal and pancreatic cancer cells to chemotherapy. PLoS ONE, 12, e0178221, 2017. [Link]
  11. Shimada M*, Goshima T, Matsuo H, Johmura Y, Haruta M, Murata K, Tanaka H, Ikawa M, Nakanishi K, Nakanishi M*: Essential role of auto-activation circuitry on Aurora B-mediated H2AX-pS121 in mitosis. Nat. Commun., 7, 12059, 2016. [Link]
  12. Johmura Y, Yamashita E, Shimada M, Nakanishi K and Nakanishi M*: Defective DNA repair increases susceptibility to senescence through extension of Chk1-mediated G2 checkpoint activation. Sci. Rep., 6, 31194, 2016. [Link]
  13. Sharif J, Endo A. T, Nakayama M, Karimi M. M, Shimada M, Katsuyama K, Goyal P, Brind'Amour J, Sun M, Sun Z, Ishikura T, Mizutani-Koseki Y, Ohara O, Shinkai Y, Nakanishi M, Xie H, Lorincz C. M*, Koseki H*: Activation of endogenous retroviruses in Dnmt1–/– ESCs involves disruption of SETDB1-mediated repression by NP95 binding to hemimethylated DNA. Cell Stem Cell, 19, 81-94, 2016. [Link]
  14. Haruta M, Shimada M*, Nishiyama A, Johmura Y, Le Tallec B, Debatisse M, Nakanishi M*: Loss of maintenance DNA methylation results in abnormal DNA origin firing during DNA replication. Biochem. Biophys. Res. Commun., 469, 960-6, 2016. [Link]
  15. Murata K, Sato S, Haruta M, Goshima T, Chiba Y, Takahashi S, Sharif J, Koseki H, Nakanishi M, Shimada M*: Physical interaction between MPP8 and PRC1 complex and its implication for regulation of spermatogenesis. Biochem. Biophys. Res. Commun., 458, 470-5, 2015. [Link]
  16. 1Goshima T, 1Shimada M* (1Both authors contributed equally to this work), Sharif J, Matsuo H, Misaki T, Johmura Y, Murata K, Koseki H, Nakanishi M*: Mammal-specific H2A variant, H2ABbd, is involved in apoptotic induction via activation of NF-κB signaling pathway. J. Biol. Chem., 289, 11656-66, 2014. [Link]
  17. Johmura Y, Shimada M, Misaki T, Naiki-Ito A, Miyoshi H, Motoyama N, Ohtani N, Hara E, Nakamura M, Morita A, Takahashi S, Nakanishi M*: Necessary and sufficient role for a mitosis skip in senescence induction. Mol. Cell, 55, 73-84, 2014. [Link]
  18. Hirokawa T, Shiotani B, Shimada M, Murata K, Johmura Y, Haruta M, Tahara H, Takeyama H, Nakanishi M*: CBP-93872 inhibits NBS1-mediated ATR activation, abrogating maintenance of the DNA double strand break specific G2 checkpoint. Cancer Res., 74, 3880-9, 2014. [Link]
  19. Nishigaki M, Kawada Y, Misaki T, Murata K, Goshima T, Hirokawa T, Yamada C, Shimada M*, Nakanishi M*: Mitotic phosphorylation of MPP8 by cyclin-dependent kinases regulates chromatin dissociation. Biochem. Biophys. Res. Commun., 432, 654-9, 2013. [Link]
  20. Shimada M, Haruta M, Niida H, Sawamoto K, Nakanishi M*: Protein phosphatase 1γ is responsible for dephosphorylation of histone H3 at Thr11 after DNA damage. EMBO Rep., 11, 883-9, 2010. [Link]
  21. Niida H, Murata K, Shimada M, Ogawa K, Ohta K, Suzuki K, Fujigaki H, Khaw AK, Banerjee B, Hande MP, Miyamoto T, Miyoshi I, Shirai T, Motoyama N, Delhase M, Appella E, Nakanishi M*: Cooperative functions of Chk1 and Chk2 reduce tumour susceptibility in vivo. EMBO J., 29, 3558-70, 2010. [Link]
  22. Niida H, Katsuno Y, Sengoku M, Shimada M, Yukawa M, Ikura M, Ikura T, Kohno K, Shima H, Suzuki H, Tashiro S, Nakanishi M*: Essential role of Tip60-dependent recruitment of ribonucleotide reductase at DNA damage sites in DNA repair during G1 phase. Genes Dev., 24, 333-8, 2010. [Link]
  23. Shimada M, Yamamoto A, Murakami-Tonami Y, Nakanishi M, Yoshida T, Aiba H, Murakami H*: Casein kinase II is required for the spindle assembly checkpoint by regulating Mad2p in fission yeast. Biochem. Biophys. Res. Commun., 388, 529-32, 2009. [Link]
  24. Katsuno Y, Suzuki A, Sugimura K, Okumura K, Zineldeen DH, Shimada M, Niida H, Mizuno T, Hanaoka F, Nakanishi M*: Cyclin A-Cdk1 regulates the origin firing program in mammalian cells. PNAS, 106, 3184-9, 2009. [Link]
  25. Zineldeen DH, Shimada M, Niida H, Katsuno Y and Nakanishi M*: Ptpcd-1 is a novel cell cycle related phosphatase that regulates centriole duplication and cytokinesis. Biochem. Biophys. Res. Commun., 380, 460-6, 2009. [Link]
  26. Shimada M, Niida H, Zineldeen DH, Tagami H, Tanaka M, Saito H, Nakanishi M*: Chk1 is a histone H3 threonine 11 kinase that regulates DNA damage-induced transcriptional repression. Cell, 132, 221-32, 2008. [Link]
  27. Shimada M, Yamada-Namikawa C, Murakami-Tonami Y, Yoshida T, Nakanishi M, Urano T, Murakami H*: Cdc2p controls the forkhead transcription factor Fkh2p by phosphorylation during sexual differentiation in fission yeast. EMBO J., 27, 132-42, 2008. [Link]
  28. Naruyama H, Shimada M, Niida H, Zineldeen DH, Hashimoto Y, Kohri K and Nakanishi M*: Essential role of Chk1 in S phase progression through regulation of RNR2 expression. Biochem. Biophys. Res. Commun., 374, 79-83, 2008. [Link]
  29. Shimada M, Namikawa-Yamada C, Nakanishi M, Murakami H*: Regulation of Cdc2p and Cdc13p is required for cell cycle arrest induced by defective RNA splicing in fission yeast. J. Biol. Chem., 280, 32640-8, 2005. [Link]
  30. Shimada M, Nabeshima K, Tougan T, Nojima H*: The meiotic recombination checkpoint is regulated by checkpoint rad+ genes in fission yeast. EMBO J., 21, 2807-18, 2002. [Link]
  31. Shimada M, Okuzaki D, Tanaka S, Tougan T, Tamai KK, Shimoda C, Nojima H*: Replication factor C3 of Schizosaccharomyces pombe, a small subunit of replication factor C complex, plays a role in both replication and damage checkpoints. Mol. Biol. Cell, 10, 3991-4003, 1999. [Link]

＜欧文＞
総説

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  1. Hanaki S and Shimada M*: Impact of FKBP52 on cell proliferation and hormone-dependent cancers. Cancer Sci., 114, 2729-38, 2023. [Link]
  2. Habara M and Shimada M*: Estrogen receptor α revised: Expression, structure, function, and stability. BioEssays, e2200148, 2022. [Link]
  3. Masaki T and Shimada M*: Decoding the Phosphatase Code: Regulation of Cell Proliferation by Calcineurin. Int J Mol Sci., 23, 1122, 2022. [Link]
  4. Hanaki S and Shimada M*: Targeting EZH2 as cancer therapy. J Biochem, 170: 1-4, 2021. [Link]
  5. Shimada M, Nakanishi M*: Aurora B twists on histones for activation. Cell Cycle, 15, 3321-2, 2016. [Link]
  6. Shimada M*, Nakanishi M*: Response to DNA damage: why do we need to focus on protein phosphatases? Front Oncol., 3, 1-14, 2013. [Link]
  7. Niida H, Shimada M, Murakami H and Nakanishi M*: Mechanisms of dNTP supply that play an essential role in maintaining genome integrity in eukaryotic cells. Cancer Sci., 101, 2505-9, 2010. [Link]
  8. Nakanishi M*, Katsuno Y, Niida H, Murakami H, Shimada M: Chk1-cyclin A/Cdk1 axis regulates origin firing programs in mammals. Chromosome Res., 18, 103-13, 2010. [Link]
  9. Nakanishi M*, Niida H, Murakami H, Shimada M: DNA damage responses in skin biology—implications in tumor prevention and aging acceleration. J. Dermatol. Sci., 56, 76-81, 2009. [Link]
  10. Shimada M, Nakanishi M*: Checkpoints meet the transcription at a novel histone milestone (H3-T11). Cell Cycle, 7, 1555-9, 2008. [Link]
  11. Nakanishi M*, Shimada M, Niida H: Genetic instability in cancer cells by impaired cell cycle checkpoints. Cancer Sci., 97, 984-9, 2006. [Link]
  12. Shimada M, Nakanishi M*: DNA damage checkpoints and cancer. J. Mol. Histol., 37, 253-60, 2006. [Link]

＜和文＞
総説

([Link]クリックで出版社のサイトへ飛びます)

  1. 羽原 誠, 島田 緑：みにれびゅう「ER陽性乳がんの新規治療法開発に向けたエストロゲン受容体制御メカニズムの解明」, 生化学（日本生化学会）, 95, p546-550, 2023 [Link]
  2. 中西 真, 島田 緑：チェックポイントキナーゼChk1による転写制御とストレス応答, 細胞工学（秀潤社）, 28, p22-26, 2009 [Link]
  3. 島田 緑, 中西 真：Chk1の新しい機能-ヒストンH3-Thr11のリン酸化を介した転写制御機構, 実験医学（羊土社）, 26, p1740-1743, 2008 [Link]
  4. 島田 緑, 中西 真：DNA損傷反応とクロマチン修飾, 細胞工学（秀潤社）, 27, p1162-1167, 2008 [Link]
  5. 島田 緑, 中西 真：チェックポイントを制御するキナーゼ群, 細胞工学（秀潤社）, 25, p924-928, 2006 [Link]
  6. 島田 緑, 村上 浩士, 中西 真：リン酸化修飾が明らかにした多彩な細胞周期チェックポイント機能, 実験医学（羊土社）, 23, p1999-2005, 2005 [Link]
  7. 島田 緑, 野島 博：減数分裂期におけるチェックポイント機構, 化学と生物（日本農芸化学会）, 41, p84-91, 2003 [Link]

著書

([Link]クリックで出版社のサイトへ飛びます)

  1. 島田 緑, 中西 真：ヒストンのリン酸化、ユビキチン化活性測定法,エピジェネティクス実験スタンダード（羊土社）, 牛島俊和他編, p240-250, 2017 [Link]
  2. 廣川 高久, 島田 緑, 竹山 廣光, 中西 真：G2/M期チェックポイントを標的としたがん細胞特異的抗がん療法増強剤の開発, がん基盤生物学（南山堂）, 清木元治総編集, p186-192, 2013 [Link]
  3. 島田 緑, 中西 真：細胞老化とチェックポイント, 細胞周期フロンティア（共立出版）, 佐方功幸他編, p114-118, 2010 [Link]