Thoracic Surgery - Surgery - Laboratories | Nagoya University GraduateSchool of Medicine

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SurgeryThoracic Surgery

Introduction

Lung cancer is the leading cause of death in Japan and most Western countries. More than 70,000 people have died of lung cancer in Japan every year. On the other hand, the 5-year survival rate of patients who underwent curative resection has increased from 52% to 70% during this decade. (from Japanese Lung Cancer Registry Study).
In our institution, video-assisted thoracoscopic surgery and robot-assisted surgery are now performed for patients with lung cancer and some mediastinal tumors. On the other hand, multimodality therapy including surgery for advanced lung cancers, thymomas, thymic cancers, and malignant pleural mesotheliomas. Malignant pleural mesothelioma is an asbestos related extremely aggressive tumor which is arising from parietal pleura and its incidence was increased in Japan. We are now considered as one of the eminent treatment facilities in our country.
We are also addressing the comprehensive basic researches for thoracic malignancies including lung cancer, thymic epithelial tumor and malignant mesothelioma.

Research Projects

  1. Analysis for tumorigenesis of thymoma and its clinical implications
  2. Establishment of the technique for histological diagnoses using images gained by micro-computed tomography and assessment for the clinical usefulness
  3. Clinical application of surgical navigation system using image-recognition technique
  4. Intra-tumoral blood flow from chest wall and the pathway of distant metastasis in patients with locally invasive lung cancer
  5. Discovery of blood-based biomarkers for thymic tumors and autoimmune diseases
  6. The prospective observational study for researching the association between the survivals and the amount of malignant pleural effusion in patients of malignant pleuritis

Faculty Members

FacultyPositionDepartment
Toshiki Okasaka Lecturer
Koji Kawaguchi Lecturer
Takayuki Fukui Lecturer
Koichi Fukumoto Assistant professor of hospital
Shota Nakamura Assistant professor of hospital
Shuhei Hakiri Assistant professor of hospital
Naoki Ozeki Assistant professor of hospital

Bibliography

  • 2016
    1. Nakamura S, Kawaguchi K, Fukui T, Fukumoto K, Okasaka T, Yokoi K. The development of large-cell carcinoma in the wall of a giant bulla complicated by Hemorrhage. Surg Case Rep, 2016; 2(1):22.
    2. Fukui T, Okasaka T, Kawaguchi K, Fukumoto K, Nakamura S, Hakiri S, Ozeki N, Yokoi K. Conditional Survival After Surgical Intervention in Patients With Non-Small Cell Lung Cancer. Ann Thorac Surg, 2016;101(5):1877-82.
    3. Kawaguchi K, Uehara K, Nakayama G, Fukui T, Fukumoto K, Nakamura S, Yokoi K. Growth rate of chemotherapy-naïve lung metastasis from colorectal cancer could be a predictor of early relapse after lung resection. Int J Clin Oncol, 2016;21(2):329-34.
    4. Fukui T, Fukumoto K, Okasaka T, Kawaguchi K, Nakamura S, Hakiri S, Ozeki N, Hirakawa A, Tateyama H, Yokoi K.Clinical evaluation of a new tumour-node-metastasis staging system for thymic malignancies proposed by the International Association for the Study of Lung Cancer Staging and Prognostic Factors Committee and the International Thymic Malignancy Interest Group. Eur J Cardiothorac Surg, 2016;49(2):574-9.
  • 2015
    1. Mori S, Usami N, Fukumoto K, Mizuno T, Kuroda H, Sakakura N, Yokoi K, Sakao Y. The Significance of the Prognostic Nutritional Index in Patients with Completely Resected Non-Small Cell Lung Cancer. PLoS One, 2015; 10;10(9)
    2. Fukui T, Taniguchi T, Kawaguchi K, Fukumoto K, Nakamura S, Sakao Y, Yokoi K. Comparisons of the clinicopathological features and survival outcomes between lung cancer patients with adenocarcinoma and squamous cell carcinoma. Gen Thorac Cardiovasc Surg, 2015; 63(9):507-13.
    3. Taniguchi T, Kawaguchi K, Fukui T, Nishimura M, Yokoi K. Primary malignant melanoma of the thymus: report of a case. Surg Today, 2015; 45(9):1187-9.
    4. Ozeki N, Kawaguchi K, Fukui T, Fukumoto K, Nakamura S, Okasaka T, Yokoi K. Which variables should be considered in patients with stage II and III non-small cell lung cancer after neoadjuvant therapy? Nagoya J Med Sci, 2015; 77(3):475-80.
    5. Hakiri S, Osada H, Ishiguro F, Murakami H, Murakami-Tonami Y, Yokoi K, Sekido Y. Functional differences between wild-type and mutant-type BRCA1-associated protein 1 tumor suppressor against malignant mesothelioma cells. Cancer Sci, 2015; 106(8):990-9.
    6. Nakamura S, Fukui T, Kawaguchi K, Fukumoto K, Hirakawa A, Yokoi K. Does ground glass opacity-dominant feature have a prognostic significance even in clinical T2aN0M0 lung adenocarcinoma? Lung Cancer, 2015; 89(1):38-42.
    7. Kato T, Iwano S, Taniguchi T, Kawaguchi K, Fukui T, Ishiguro F, Fukumoto K, Nakamura S, Hirakawa A, Yokoi K. The contact length between the tumor contour and the lung on computed tomography is a risk factor for pleural recurrence after complete resection of thymoma. Gen Thorac Cardiovasc Surg, 2015; 63(6):343-8.
    8. Fukumoto K, Taniguchi T, Usami N, Kawaguchi K, Fukui T, Ishiguro F, Nakamura S, Yokoi K. The ABO blood group is an independent prognostic factor in patients with resected non-small cell lung cancer. J Epidemiol, 2015; 25(2):110-6.
    9. Fukumoto K, Ito H, Matsuo K, Tanaka H, Yokoi K, Tajima K, Takezaki T. Cigarette smoke inhalation and risk of lung cancer: a case-control study in a large Japanese population. Eur J Cancer Prev. 2015; 24(3):195-200.
    10. Mizuno T, Okumura M, Asamura H, Yoshida K, Niwa H, Kondo K, Horio H, Matsumura A, Yokoi K; Japanese Association for Research on Thymus. Surgical management of recurrent thymic epithelial tumors: a retrospective analysis based on the Japanese nationwide database. J Thorac Oncol, 2015; 10(1):199-205.
    11. Fukumoto K, Taniguchi T, Usami N, Kawaguchi K, Fukui T, Ishiguro F, Nakamura S, Yokoi K. Preoperative plasma D-dimer level is an independent prognostic factor in patients with completely resected non-small cell lung cancer. Surg Today, 2015; 45(1):63-7.
    12. Ishikawa Y, Tateyama H, Yoshida M, Takami K, Matsuguma H, Taniguchi T, Usami N, Kawaguchi K, Fukui T, Ishiguro F, Nakamura S, Yokoi K. Micronodular thymoma with lymphoid stroma: an immunohistochemical study of the distribution of Langerhans cells and mature dendritic cells in six patients. Histopathology, 2015; 66(2):300-7.
  • 2014
    1. Ozeki N, Iwano S, Taniguchi T, Kawaguchi K, Fukui T, Ishiguro F, Fukumoto K, Nakamura S, Hirakawa A, Yokoi K. Therapeutic surgery without a definitive diagnosis can be an option in selected patients with suspected lung cancer. Interact Cardiovasc Thorac Surg, 2014; 19(5):830-7.
    2. Kawaguchi K, Yokoi K, Niwa H, Ohde Y, Mori S, Okumura S, Shiono S, Ito H, Yano M, Shigemitsu K, Hiramatsu Y, Okami J, Saito H. Trimodality therapy for lung cancer with chest wall invasion: initial results of a phase II study. Ann Thorac Surg, 2014; 98(4):1184-91.
    3. Yokoi K, Taniguchi T, Usami N, Kawaguchi K, Fukui T, Ishiguro F. Surgical management of locally advanced lung cancer. Gen Thorac Cardiovasc Surg, 2014; 62(9):522-30.
    4. Ozeki N, Fukui T, Taniguchi T, Usami N, Kawaguchi K, Ito S, Sakao Y, Mitsudomi T, Hirakawa A, Yokoi K. Significance of the serum carcinoembryonic antigen level during the follow-up of patients with completely resected non-small-cell lung cancer. Eur J Cardiothorac Surg, 2014; 45(4):687-92.
    5. Fukui T, Taniguchi T, Kawaguchi K, Yokoi K. Spontaneous regression of thymic epithelial tumours. Interact Cardiovasc Thorac Surg, 2014; 18(3):399-401.
    6. Kawaguchi K, Taniguchi T, Usami N, Fukui T, Ishiguro F, Nakamura S, Yokoi K. FDG PET/CT is useful for detecting infiltration to the port site in patients with malignant pleural mesothelioma. Gen Thorac Cardiovasc Surg, 2014; 62(3):157-62.
    7. Ozeki N, Kawaguchi K, Taniguchi T, Yokoi K. Primary pulmonary solitary fibrous tumour with brain metastases. Eur J Cardiothorac Surg, 2014; 45(2):386-8.
  • 2013
    1. Nakamura S, Fukui T, Taniguchi T, Usami N, Kawaguchi K, Ishiguro F, Hirakawa A, Yokoi K. Prognostic impact of tumor size eliminating the ground glass opacity component: modified clinical T descriptors of the tumor, node, metastasis classification of lung cancer. J Thorac Oncol, 2013; 8(12):1551-7.
    2. Ishikawa Y, Kato K, Taniguchi T, Kawaguchi K, Yokoi K. Imaging of a case of metaplastic thymoma on 18F-FDG PET/CT. Clin Nucl Med, 2013; 38(12):e463-4.
    3. Nakamura S, Taniguchi T, Yokoi K. Solitary fibrous tumour of the mediastinal pleura: the origin detected with three-dimensional computed tomography angiography. Eur J Cardiothorac Surg, 2013; 43(3):e92.
    4. Mizuno T, Taniguchi T, Ishikawa Y, Kawaguchi K, Fukui T, Ishiguro F, Nakamura S, Yokoi K. Pulmonary metastasectomy for osteogenic and soft tissue sarcoma: who really benefits from surgical treatment? Eur J Cardiothorac Surg, 2013; 43(4):795-9.
    5. Sakakura N, Tateyama H, Nakamura S, Taniguchi T, Usami N, Ishikawa Y, Kawaguchi K, Yokoi K. Diagnostic reproducibility of thymic epithelial tumors using the World Health Organization classification: note for thoracic clinicians. Gen Thorac Cardiovasc Surg, 2013; 61(2):89-95.
    6. Ishiguro F, Murakami H, Mizuno T, Fujii M, Kondo Y, Usami N, Taniguchi T, Yokoi K, Osada H, Sekido Y. Membranous expression of activated leukocyte cell adhesion molecule contributes to poor prognosis and malignant phenotypes of non-small-cell lung cancer. J Surg Res, 2013; 179(1):24-32.
  • 2012
    1. Nakamura S, Tateyama H, Taniguchi T, Ishikawa Y, Kawaguchi K, Fukui T, Mizuno T, Ishiguro F, Yokoi K. Multilocular thymic cyst associated with thymoma: a clinicopathologic study of 20 cases with an emphasis on the pathogenesis of cyst formation. Am J Surg Pathol, 2012; 36(12):1857-64.
    2. Fukumoto K, Taniguchi T, Ishikawa Y, Kawaguchi K, Fukui T, Kato K, Matsuo K, Yokoi K. The utility of [18F]-fluorodeoxyglucose positron emission tomography-computed tomography in thymic epithelial tumours. Eur J Cardiothorac Surg, 2012; 42(6):e152-6.
    3. Ishikawa Y, Iwano S, Usami N, Yokoi K. An anomalous segmental vein of the left upper lobe of the lung: preoperative identification by three-dimensional computed tomography pulmonary angiography. Interact Cardiovasc Thorac Surg, 2012; 15(3):512-3.
    4. Kawaguchi K, Miyaoka E, Asamura H, Nomori H, Okumura M, Fujii Y, Nakanishi Y, Eguchi K, Mori M, Sawabata N, Yokoi K; Japanese Joint Committee of Lung Cancer Registry. Modern surgical results of lung cancer involving neighboring structures: a retrospective analysis of 531 pT3 cases in a Japanese Lung Cancer Registry Study. J Thorac Cardiovasc Surg, 2012; 144(2):431-7.
    5. Fukui T, Yatabe Y, Kobayashi Y, Tomizawa K, Ito S, Hatooka S, Matsuo K, Mitsudomi T. Clinicoradiologic characteristics of patients with lung adenocarcinoma harboring EML4-ALK fusion oncogene. Lung Cancer, 2012; 77(2):319-25.
    6. Ishiguro F, Murakami H, Mizuno T, Fujii M, Kondo Y, Usami N, Yokoi K, Osada H, Sekido Y. Activated leukocyte cell-adhesion molecule (ALCAM) promotes malignant phenotypes of malignant mesothelioma. J Thorac Oncol, 2012; 7(5):890-9.
    7. Hosono Y, Yamaguchi T, Mizutani E, Yanagisawa K, Arima C, Tomida S, Shimada Y, Hiraoka M, Kato S, Yokoi K, Suzuki M, Takahashi T. MYBPH, a transcriptional target of TTF-1, inhibits ROCK1, and reduces cell motility and metastasis. EMBO J, 2012; 18;31(2):481-93.
  • 2011
    1. Fukumoto K, Usami N, Okasaka T, Kawaguchi K, Okagawa T, Suzuki H, Yokoi K. Late breast metastasis from resected lung cancer diagnosed by epidermal growth factor receptor gene mutation. Lung Cancer, 2011; 74(2):352-3.
    2. Ohata N, Usami N, Kawaguchi K, Tateyama H, Yokoi K. Type AB thymoma with brain metastasis: Report of a case. Surg Today, 2011; 41(10):1436-8.
    3. Mizuno T, Usami N, Okasaka T, Kawaguchi K, Okagawa T, Yokoi K. Complete spontaneous regression of non-small cell lung cancer followed by adrenal relapse. Chest, 2011; 140(2):527-8.
    4. Kawaguchi K, Usami N, Okasaka T, Yokoi K. Multiple thymic carcinoids. Ann Thorac Surg, 2011; 91(6):1973-5.
    5. Kawaguchi K, Taniguchi T, Usami N, Yokoi K. Intrapulmonary solitary fibrous tumor. Gen Thorac Cardiovasc Surg, 2011; 59(1):61-4.

Research Keywords

Lung cancer、 thymoma、 thymic epithelial tumor、 mesothelioma