Introduction

Orthopedics is the medical specialty that focuses on congenital and acquired diseases and traumas in the locomotive system consisting of bones, cartilages, muscles, tendons, ligaments, and spinal and peripheral nervous system. Orthopedic surgeons care for patients of all ages, from newborns with congenital deformity to elderly persons with degenerative arthritis, by nonsurgical and surgical modalities. In Japan, now entering the stage of 'super-aged society', elucidation of pathophysiology and therapeutic development for the locomotive syndrome is an urgent issue to extend healthy-life span of the elderly. Basic medical research on the special problems of the musculoskeletal system is currently centered around orthopedics.
Our department of orthopaedic surgery consists of six subspecialties including spine surgery, hip arthroplasty surgery, rheumatology, pediatric orthopedics, arthroscopic surgery and sports medicine, and musculoskeletal oncology. Each subspecialty group cooperates with each other to provide better medical care and tackles a broad range of individual problems to innovate treatment strategies. Recent progress in molecular genetics/biology and regenerative medicine will make it possible to unravel pathophysiology/etiology for spinal cord injury, cartilage degeneration, and bone dysplasia, which have been hardly addressed so far, and to develop definitive therapies for them. Up until now, and in the future, our department is dedicated to translational research in order to conquer the intractable conditions of our musculoskeletal systems.

Research Projects

Pediatric Orthopedic Group

Achondroplasia is a rare bone disease characterized with shorten-limbed short stature caused by gain-of-function mutations in FGFR3. Growth hormone administration and limb lengthening surgery have been performed for more than 30 years, but the former has an only slight effect and the latter has a lot of complications. Vosoritide (CNP analog), which is an inhibitor of FGFR3, has been released in August, 2022, in Japan, but daily subcutaneous injection is too much burden for children.

Oral medication of meclizine showed an effect on experimental models of achondroplasia

We identified that meclizine, which has been used as an anti-motion sickness, had an inhibitory effect of FGFR3. In a cell model of achondroplasia, meclizine rescued inhibitory effect on chondrocyte proliferation. In an explant culture model, meclizine increased FGF2-mediated bone growth. Oral administration of meclizine promoted bone growth in a mouse model of achondroplasia. Meclizine also partially rescued spinal canal stenoses in a mouse model of achondroplasia.

Investigator-initiated trials for children with achondroplasia

Meclizine is expected to compliance for children due to the oral medication. Using cheap drug is economically advantage of developing a therapy for the rare bone disease. After completing preclinical studies, which are needed to perform clinical trials, according to the instruction by PMDA, we performed three investigator-initiated trials. We confirmed that there were no concerns of safety in phase Ia and phase Ib clinical trials. Thus, we performed phase II clinical trial. After 26 weeks of meclizine administration, arm span was substantially increased, but not body height. We will perform further clinical trials in the future.

Collaboration with rare disease data registry of Japan and patients associations

We established Rare Disease Data Registry of Japan for patients with achondroplasia. To find appropriate treatments, we will collect the patients’ treatment history, body height, and quality of life. Using this registry, we would like to suggest best options to each patient at each stage in the future. We are also providing the information of Rare Disease Data Registry of Japan and meclizine research to patients’ associations.

Rheumatology Group

Development of a novel therapeutic strategy for osteoarthritis through regulation of intracellular metabolic changes

We are conducting basic research aimed at developing novel therapeutic strategies for osteoarthritis by targeting intracellular metabolic regulation. We have demonstrated that, under inflammatory conditions, chondrocytes exhibit multiple intracellular metabolic alterations, including a marked enhancement of anaerobic glycolysis. Focusing on AMP-activated protein kinase (AMPK) as a central molecule that integratively regulates these metabolic changes, we showed that reduced AMPK activity leads to multifaceted functional impairments in chondrocytes. Furthermore, analyses using a glucose metabolism inhibitor (2-deoxy-D-glucose, 2DG), a lipid metabolism modulator (fatostatin), and a glutamine metabolism inhibitor (epigallocatechin gallate, EGCG) revealed that all of these metabolic modulators maintained AMPK activation and significantly attenuated cartilage degeneration in an osteoarthritis mouse model.

Tsurumai Biologics Communication Registry (TBCR)

The Tsurumai Biologics Communication Registry (TBCR) was established in 2008 with Nagoya University playing a central role, in collaboration with rheumatology-related institutions, to construct a database of patients with rheumatoid arthritis treated with b/tsDMARDs. TBCR is one of the largest longitudinal registries in Japan, with more than 4,000 registered patients. By collecting and analyzing long-term, real-world clinical data that cannot be sufficiently obtained from clinical trials or post-marketing surveillance, this registry has provided valuable insights into the effectiveness and safety of b/tsDMARDs in routine clinical practice. Findings derived from TBCR have contributed to the optimization of treatment strategies for rheumatoid arthritis.

Specified Clinical Research

Nagoya University Hospital was certified as a Core Clinical Research Hospital under the Medical Care Act in January 2016. Core Clinical Research Hospitals are required to conduct specified clinical research and disseminate high-quality scientific publications based on these studies. To date, our group has completed two specified clinical research projects and published three peer-reviewed articles. Through these efforts, our group is committed to promoting scientifically rigorous and ethically sound clinical research, thereby contributing to the generation of robust clinical evidence in the field of rheumatoid arthritis.

https://pubmed.ncbi.nlm.nih.gov/31390271/

https://pubmed.ncbi.nlm.nih.gov/32534200/

https://pubmed.ncbi.nlm.nih.gov/40188084/

Arthroscopic Surgery and Sports Medicine Group

Search for Factors Suppressing Knee Osteoarthritis

Knee osteoarthritis is a disease that causes pain due to degeneration of knee joint cartilage and osteophyte formation, which results in limiting activities of daily living and reducing quality of life (QOL). Currently, intra-articular hyaluronic acid injections are widely used clinically, but multiple injections may be necessary to maintain efficacy. Our research group, recognizing this situation, is conducting exploratory research to develop drug therapies that could replace intra-articular hyaluronic acid injections. We discovered that overexpression of hyaluronic acid synthase (HAS2) in chondrocytes exerts anti-inflammatory effects in bovine and human chondrocytes. We are currently focusing our research on whether the overexpression of HAS2 via intra-articular injection of viral vectors exerts anti-inflammatory effects on cartilage tissue.

Search for Pharmacological Treatments for Rotator Cuff Tears

Rotator cuff tears can result from trauma, but in most cases, they arise from degenerative changes associated with aging and inflammation. Intrinsic factors such as repetitive stress, reduced blood flow, and alterations in matrix composition are thought to be involved. For symptomatic rotator cuff tears, intra-articular injections of hyaluronic acid, steroids, or local anesthetics (such as lidocaine) are sometimes administered in clinical practice. However, no effective drug therapy specifically indicated for rotator cuff tears is currently established for use under insurance coverage in Japan. Our team has identified the anti-inflammatory effect of 4-methylumbeliferone (4-MU), a hyaluronic acid synthesis inhibitor, in anterior cruciate ligament-derived cells. Given the histological similarity between ligaments and tendons, we expect 4-MU's anti-inflammatory effect to also apply to tendon-derived cells. We are conducting research with the aim of developing 4-MU as a novel drug therapy for rotator cuff tears.

Musculoskeletal Oncology Group

Bone and soft tissue tumors are rare diseases, but they can have a major impact not only on survival but also on postoperative function and quality of life (QOL). Our Orthopaedic Oncology Research Group aims to improve patient outcomes by integrating basic research, translational studies, and clinical investigations. Through multidisciplinary approaches, we seek to clarify tumor biology, develop innovative treatment strategies, and optimize surgical reconstruction to preserve function and enhance long-term QOL for patients with musculoskeletal tumors.

Bone Formation Induced by Thermal Stimulation

Delayed bone formation and insufficient bone healing after tumor reconstruction remain significant challenges in orthopaedic oncology. Our research focuses on the effects of thermal stimulation on bone metabolism and bone formation. Using in vitro experiments and animal models, we investigate how controlled heat stimulation influences osteoblast activity and bone-related signaling pathways. This project aims to establish a minimally invasive and novel strategy to promote bone formation, which may contribute to improved functional recovery after tumor surgery.

Pathological Analysis of Uncharacterized Tumors Using Next Generation Sequencing

Some bone and soft tissue tumors are difficult to diagnose or predict clinically using conventional histopathological methods alone. To address this challenge, we use Next Generation Sequencing (NGS) to comprehensively analyze the genetic characteristics of uncharacterized tumors. By identifying gene mutations, copy number alterations, and disrupted signaling pathways, we aim to improve diagnostic accuracy and discover potential therapeutic targets. This research contributes to the advancement of precision medicine in musculoskeletal oncology.

Relationship Between Novel Tumor Prostheses and Bone Strength

Limb-salvage surgery with tumor prosthetic reconstruction plays a critical role in the treatment of malignant bone tumors. However, long-term outcomes are often affected by bone quality and mechanical stability around the implant. Our research examines the relationship between novel tumor prosthetic systems and bone strength, using radiological assessment and clinical data. By clarifying how bone quality, mechanical loading, and implant design interact, we aim to develop more durable reconstructions that provide better functional outcomes for patients.

Spine Group

Spinal cord injury causes impairments in motor, sensory, and autonomic functions and remains a significant medical challenge with limited effective treatments. We are conducting research from various angles aiming for fundamental treatment of SCI or to enhance patients’ quality of life (QOL).

Potential of enoxaparin for spinal cord injury treatment

Heparan sulfate suppresses signals that inhibit axonal regeneration. We have demonstrated that enoxaparin, an existing low molecular weight heparin drug, reverses axonal regeneration inhibition and promotes functional recovery in a rat spinal cord injury model. Enoxaparin is a candidate for a novel nerve regeneration treatment and is expected to be clinically applied for central nervous system injuries.

Interaction between neurons and microglia after spinal cord injury

Microglia are immune cells in the central nervous system that influence the recovery process by regulating the environment and rebuilding neural circuits after injury. Using in vivo imaging of the brain and spinal cord in mouse models, we identified changes in neural activity in brain neurons after spinal cord injury and interactions between injured axons and microglia.

Pathological analysis of fibrotic scar formation after spinal cord injury

In spinal cord injury, scar tissue formed at the injury site inhibits axon regeneration. This scar tissue includes glial scars and fibrotic scars, and the pathology of fibrotic scars remains unclear. Focusing on Meflin, a fibroblast marker, we have clarified part of the pathology of fibrotic scars after spinal cord injury.

Faculty Members

Faculty	Position	Department
IMAGAMA Shiro	Professor	Orthopaedics
NISHIDA Yoshihiro	Professor	Rehabilitation
MISHIMA Kenichi	Associate Professor	Orthopaedics
NAKASHIMA Hiroaki	Associate Professor	Orthopaedics
ASAI Shuji	Lecturer	Rheumatology
MATSUSHITA Masaki	Lecturer	Orthopaedics
ISHIZUKA Shinya	Lecturer	Orthopaedics
IKUTA Kunihiro	Lecturer	Orthopaedics
TERABE Kenya	Lecturer	Rheumatology
ITO Sadayuki	Assistant Professor	Orthopaedics
OSAWA Yusuke	Assistant Professor	Orthopaedics
SAKAI Tomohisa	Assistant Professor	Orthopaedics
SEGI Naoki	Assistant Professor	Orthopaedics
SUZUKI Mochihito	Assistant Professor	Rheumatology
OUCHIDA Jun	Assistant Professor	Orthopaedics
SAKAGUCHI Takefumi	Assistant Professor	Orthopaedics
FUNAHASHI Hiroto	Assistant Professor	Orthopaedics

Bibliography

• 2025

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  7. Kawase T, Yamada S, Kishimoto Y, Ito D, Komori S, Kondo A, Iida M, Kawashima I, Takegami Y, Hashizume A, Imagama S, Katsuno M. Bone Fragility and Fracture Characteristics in Patients With Spinal and Bulbar Muscular Atrophy. Eur J Neurol. 2025. DOI: 10.1111/ene.70457
  8. Date S, Fujiwara K, Segi N, Nakajima H, Ito S, Ouchida J, Yamauchi I, Imagama S. Motor Evoked Potential-Based Spinal Cord Function Assessment in Intraoperative Monitoring Using Machine Learning Model. Annu Int Conf IEEE Eng Med Biol Soc. 2025. DOI: 10.1109/EMBC58623.2025.11254360
  9. Matsushita M, Kitoh H, Kubota T, Okada K, Mishima K, Sawamura K, Kitaoka T, Fujiwara M, Kato Y, Amano Y, Nishida K, Imagama S. Efficacy and Safety of Oral Meclizine for Growth Promotion in Children with Achondroplasia: A Phase 2 Clinical Trial. Calcif Tissue Int. 2025. DOI: 10.1007/s00223-025-01449-8
  10. Yamamoto H, Suzuki M, Kojima T, Sugiura T, Saito Y, Saito Y, Terabe K, Ohashi Y, Sato R, Hasegawa J, Ohno Y, Nagai K, Ohnishi C, Sugiura H, Fujita H, Nagayoshi M, Kojima M, Asai S, Imagama S. Evaluation of physical function in rheumatoid arthritis patients by locomotive syndrome stage. Mod Rheumatol. 2025. DOI: 10.1093/mr/roaf098
  11. Nagatani Y, Segi N, Ito S, Ouchida J, Yamauchi I, Ode Y, Okada Y, Kagami Y, Tsushima M, Tomita H, Morishita K, Oyama H, Kanemura T, Imagama S, Nakashima H. Fine versus Sclerotic Trabecular Bone Remodeling/Restructure: A Refined Radiographic Predictor for Long-Term Segment Stability After Posterior Lumbar Interbody Fusion. Global Spine J. 2025. DOI: 10.1177/21925682251385533
  12. Segi N, Nakashima H, Imaizumi T, Ito S, Ouchida J, Yamauchi I, Ode Y, Nagatani Y, Okada Y, Kagami Y, Imagama S. Cost and outcome comparison between intradiscal condoliase injection and surgical treatment for lumbar disc herniation based on real-world data analysis. Sci Rep. 2025. DOI: 10.1038/s41598-025-23988-8
  13. Mori S, Hoshino A, Uemura JI, Sano M, Nishiura Y, Morikawa I, Iwatsuki K, Hirata H, Hoshiyama M. Envelope of Alpha Activity in Depression and Anxiety: A Novel Analysis of the Second-Order Derivatives of Alpha Envelope of EEG. Clin EEG Neurosci. 2025. DOI: 10.1177/15500594251387497
  14. Sawamura K, Matsushita M, Hamada S, Mishima K, Imagama S. Chondrolysis following surgical resection of an osteoid osteoma of the hip in an adolescent: a case report. Mod Rheumatol Case Rep. 2025. DOI: 10.1093/mrcr/rxaf071
  15. Suzuki M, Asai S, Ohashi Y, Sobue Y, Terabe K, Imagama S. Nutritional status and frailty in rheumatoid arthritis: A multicenter observational study (T-FLAG). Arch Gerontol Geriatr. 2026. DOI: 10.1016/j.archger.2025.106073
  16. Ido H, Osawa Y, Takegami Y, Funahashi H, Iida H, Imagama S. Changes in spinopelvic alignment and patient-reported outcomes after total hip arthroplasty in osteonecrosis of the femoral head. Eur Spine J. 2025. DOI: 10.1007/s00586-025-09532-2
  17. Segi N, Nakashima H, Imagama S, Egawa S, Sakai K, Kusano K, Tsutsui S, Hirai T, Matsukura Y, Wada K, Katsumi K, Koda M, Kimura A, Furuya T, Maki S, Nagoshi N, Nishida N, Nagamoto Y, Oshima Y, Ito S, Endo T, Mori K, Nakajima H, Murata K, Miyagi M, Kaito T, Yamada K, Banno T, Kato S, Ohba T, Takahata M, Moridaira H, Otsuki B, Katoh H, Kanno H, Taneichi H, Kawaguchi Y, Takeshita K, Nakamura M, Yamazaki M, Yoshii T. Impact of postoperative C5 palsy on quality of life in patients with cervical ossification of the posterior longitudinal ligament: a prospective study. J Neurosurg Spine. 2025. DOI: 10.3171/2025.6.SPINE25368
  18. Segi N, Nakashima H, Oishi R, Ito S, Ouchida J, Yamauchi I, Nagatani Y, Seki T, Takegami Y, Ishizuka S, Hasegawa Y, Imagama S. Association between the central sensitization inventory score and health-related quality of life in community-dwelling middle-aged and older adults. PLoS One. 2025. DOI: 10.1371/journal.pone.0335923
  19. Saeki M, Yoneda H, Kano T, Yamamoto M. Correlation between dorsal tilt and midcarpal alignment in distal radial fractures or malunions: a radiographic study. J Hand Surg Eur Vol. 2025. DOI: 10.1177/17531934251385833
  20. Takahashi S, Takegami Y, Nakashima H, Mishima K, Iwase T, Imagama S. Radiographic parameters of nonunion in Vancouver type C periprosthetic femoral fractures treated with plate fixation. Arch Orthop Trauma Surg. 2025. DOI: 10.1007/s00402-025-06088-0
  21. Nakashima H, Yoshida G, Kanemura T, Ito S, Segi N, Ouchida J, Tsushima M, Tomita H, Morishita K, Imagama S. Preliminary observations on neuromuscular pathways of the lower extremities: findings from intraoperative nerve root stimulation. Nagoya J Med Sci. 2025. DOI: 10.18999/nagjms.87.3.538
  22. Nakashima H, Ota K, Ito S, Segi N, Ouchida J, Yamauchi I, Ode Y, Imagama S. Incidence and risk factors of cerebrospinal fluid leakage related complications after spinal intradural tumor resection. Nagoya J Med Sci. 2025. DOI: 10.18999/nagjms.87.3.521
  23. Nakashima H, Ito S, Segi N, Ouchida J, Yamauchi I, Sato K, Imagama S. Clinical outcomes of posterior lumbar interbody fusion in chronic renal failure patients on hemodialysis. Nagoya J Med Sci. 2025. DOI: 10.18999/nagjms.87.3.528
  24. Nakashima H, Ito S, Segi N, Ouchida J, Yamauchi I, Takegami Y, Ishizuka S, Wakai K, Hasegawa Y, Imagama S. Dietary intake and its association with sarcopenia in older adults: a cross-sectional analysis. Nagoya J Med Sci. 2025. DOI: 10.18999/nagjms.87.3.451
  25. Nakashima H, Ito S, Segi N, Ouchida J, Yamauchi I, Morita Y, Kanemura T, Imagama S. Current status of indirect decompression with lateral lumbar interbody fusion. Nagoya J Med Sci. 2025. DOI: 10.18999/nagjms.87.3.381
  26. Yamauchi I, Nakashima H, Ito S, Segi N, Ouchida J, Morita Y, Ode Y, Nagatani Y, Okada Y, Ando K, Imagama S. Comparative analysis of bone regeneration in critical-sized defects using self-assembling peptide hydrogel-178, bone morphogenetic protein-2, and calcium phosphate scaffolds in a rat femur model. Nagoya J Med Sci. 2025. DOI: 10.18999/nagjms.87.3.421
  27. Kawamura Y, Ishizuka S, Sakai T, Tsuchiya S, Kurokouchi K, Takahashi S, Miyamoto K, Oba H, Sakaguchi T, Mizuno T, Kawashima I, Imagama S. Comparison of Anchor Hole Enlargement Between Biodegradable and All-Soft Suture Anchors After Arthroscopic Bankart Repair: Longitudinal 2-Year Follow-up Study. Am J Sports Med. 2025. DOI: 10.1177/03635465251383158
  28. Nakashima H, Kanbara S, Ito S, Segi N, Ouchida J, Yamauchi I, Morita Y, Imagama S. Longitudinal changes in spinal kyphosis, lordosis, and range of motion in aging populations: a 10-year study. Eur Spine J. 2025. DOI: 10.1007/s00586-025-09386-8
  29. Tanaka S, Osawa Y, Takegami Y, Funahashi H, Ido H, Asamoto T, Imagama S. Risk factors for delayed pubic union after eccentric rotational acetabular osteotomy. Int Orthop. 2025. DOI: 10.1007/s00264-025-06676-0
  30. Bian H, Fujio M, Matsushita M, Esaki R, Tsuboi M, Wakasugi M, Liu Y, Imagama S, Hibi H. FGFR3 gain-of-function delays intramembranous bone healing in a mouse calvarial fracture model. Biochem Biophys Res Commun. 2025. DOI: 10.1016/j.bbrc.2025.152799
  31. Ode Y, Segi N, Ito S, Ouchida J, Yamauchi I, Nagatani Y, Okada Y, Takeichi Y, Kagami Y, Morishita K, Oishi R, Miyairi Y, Morita Y, Tachi H, Ohshima K, Oyama H, Ogura K, Shinjo R, Ohara T, Tsuji T, Kanemura T, Imagama S, Nakashima H. Impact of Nutritional Risk on Complications and Recovery in the Older People: A Geriatric Nutritional Risk Index-Based Study. Spine Surg Relat Res. 2025. DOI: 10.22603/ssrr.2025-0016
  32. Takegami Y, Imaizumi T, Sato K, Osawa Y, Funahashi H, Imagama S. Impact of a national reimbursement policy on anti-osteoporosis medication prescription at discharge after hip-fracture surgery in Japan: an interrupted time-series analysis. Osteoporos Int. 2025. DOI: 10.1007/s00198-025-07721-9
  33. Miyagawa K, Takegami Y, Nakashima H, Mishima K, Kobayashi K, Imagama S. Periprosthetic femoral fractures following bipolar hemiarthroplasty: A descriptive multicenter study exploring associations with mortality and functional status. Injury. 2025. DOI: 10.1016/j.injury.2025.112776
  34. Otaka K, Osawa Y, Takegami Y, Funahashi H, Ido H, Asamoto T, Tanaka S, Imagama S. A simple linear alternative to necrotic volume for predicting collapse in osteonecrosis of the femoral head. Skeletal Radiol. 2025. DOI: 10.1007/s00256-025-05056-4
  35. Ido H, Osawa Y, Takegami Y, Funahashi H, Ozawa Y, Asamoto T, Imagama S. Radiographic Predictors of Leg Shortening After Curved Intertrochanteric Varus Osteotomy in Osteonecrosis of the Femoral Head. Orthop Surg. 2025. DOI: 10.1111/os.70172
  36. Asai S, Terabe K, Hasegawa J, Yoshioka Y, Kato T, Kojima T, Ohno Y, Kobayakawa T, Watanabe T, Sobue Y, Nishiume T, Kato M, Fujibayashi T, Hirano Y, Kanayama Y, Takemoto T, Watanabe T, Hanabayashi M, Matsubara H, Suzuki M, Sato R, Sugiura T, Takahashi N, Imagama S. Effects of concomitant methotrexate and predictors of remission in Janus kinase inhibitor therapy for rheumatoid arthritis. Joint Bone Spine. 2026. DOI: 10.1016/j.jbspin.2025.105961
  37. Yoneda H, Yamaga T, Fujiwara T, Komori Y, Shimada M, Kato Y, Oyama S, Shimoda S, Yamamoto M, Hirata H. Application of artificial muscle e-rubber for healthcare sensing: verification of measurement properties as a smart insole. Front Bioeng Biotechnol. 2025. DOI: 10.3389/fbioe.2025.1639630
  38. Morozumi M, Ozaki T, Nishitsuji K, Takeda-Uchimura Y, Matsumoto A, Ito S, Imagama S, Ishiguro N, Yagi H, Kato K, Akama TO, Kosugi T, Maruyama S, Kadomatsu K, Rosen SD, Noble-Haeusslein LJ, Uchimura K. Enhanced locomotor recovery in mice lacking GlcNAc6ST1 and GlcNAc6ST4 following spinal cord injury. Life Sci Alliance. 2025. DOI: 10.26508/lsa.202503469
  39. Saito Y, Suzuki M, Kojima T, Yamamoto H, Saito Y, Terabe K, Ohashi Y, Sato R, Hasegawa J, Ohno Y, Nagai K, Ohnishi C, Sugiura H, Fujita H, Nagayoshi M, Kojima M, Asai S, Imagama S. Features of sarcopenic obesity in rheumatoid arthritis patients. Geriatr Gerontol Int. 2025. DOI: 10.1111/ggi.70149
  40. Urakawa H, Ikuta K, Sakai T, Koike H, Fujito T, Nishida Y, Imagama S. Voriconazole-induced periostitis in a child with finger pain and nodules: case report and literature review. BMC Musculoskelet Disord. 2025. DOI: 10.1186/s12891-025-09059-z
  41. Tanaka S, Osawa Y, Takegami Y, Funahashi H, Imagama S. Ipsilateral Lower-Limb Alignment after Total Hip Arthroplasty for Dysplastic Hip Osteoarthritis. J Arthroplasty. 2025. DOI: 10.1016/j.arth.2025.07.068
  42. Koike H, Nishida Y, Urakawa H, Ikuta K, Sakai T, Ito K, Imagama S. The utility of apparent diffusion coefficient maps for evaluating chemotherapy response and prognosis in osteosarcoma. J Orthop Sci. 2025. DOI: 10.1016/j.jos.2025.07.006
  43. Asai H, Osawa Y, Takegami Y, Funahashi H, Imagama S. Minimum 10-Year Outcomes of Total Hip Arthroplasty After Periacetabular Osteotomy. J Arthroplasty. 2025. DOI: 10.1016/j.arth.2025.07.063
  44. Nobori T, Takegami Y, Tokutake K, Nakashima H, Mishima K, Okamoto M, Okui N, Imagama S. Comparative outcomes of in-situ fixation and fixation after reduction in geriatric patients with severe valgus-impacted femoral neck fractures: a retrospective multicenter (TRON group) study. Nagoya J Med Sci. 2025. DOI: 10.18999/nagjms.87.2.295
  45. Morita Y, Shiraki Y, Kato A, Nagatani Y, Ando R, Nakashima H, Imagama S, Enomoto A. Meflin/Islr is a marker of fibroblasts that arise in fibrotic regions after spinal cord injury. Nagoya J Med Sci. 2025. DOI: 10.18999/nagjms.87.2.305
  46. Ouchida J, Nakashima H, Ito S, Segi N, Kanemura T, Ohara T, Tsuji T, Shinjo R, Yamauchi I, Ode Y, Imagama S. Preoperative undernutrition in older people with adult spinal deformities is associated with worse postoperative sagittal vertical axis. J Orthop Sci. 2025. DOI: 10.1016/j.jos.2025.07.001
  47. Yokoyama H, Asano K, Yoneda H, Iwatsuki K, Mabuchi M, Yamamoto M. Clinical outcomes of percutaneous intramedullary headless screw fixation with an oblique technique for the treatment of proximal and middle phalanx fractures. J Orthop Sci. 2026. DOI: 10.1016/j.jos.2025.06.017
  48. Osawa Y, Takegami Y, Funahashi H, Ido H, Asamoto T, Imagama S. Conventional versus computer-tomography based navigation assisted eccentric rotational acetabular osteotomy in less experienced surgeons. Arch Orthop Trauma Surg. 2025. DOI: 10.1007/s00402-025-05990-x
  49. Tachi H, Takegami Y, Okura T, Tokutake K, Nakashima H, Mishima K, Kasai T, Imagama S. Comparison of Clinical Outcomes of Periprosthetic Fractures Between Cemented vs Cementless Stem Methods After Initial Total Hip Arthroplasty or Bipolar Hemiarthroplasty: A Multicenter Analysis (TRON Study). Arthroplast Today. 2025. DOI: 10.1016/j.artd.2025.101699
  50. Suzuki M, Asai S, Ohashi Y, Sobue Y, Terabe K, Sato R, Hasegawa J, Ohno Y, Sugiura T, Imagama S. The impact of social frailty and physical function on laughter frequency in rheumatoid arthritis patients: data from a multicenter observational study (Tsurumai-frailty and locomotive syndrome of rheumatoid arthritis for globalization). Mod Rheumatol. 2025. DOI: 10.1093/mr/roaf065
  51. Urakawa H, Ikuta K, Sakai T, Koike H, Fujito T, Nishida Y, Imagama S. Natural course of patients diagnosed with nodular fasciitis. BMC Musculoskelet Disord. 2025. DOI: 10.1186/s12891-025-08895-3
  52. Sobue Y, Kosugiyama H, Asai S, Ogawa Y, Yoneda M, Maruyama K, Kaneko M, Kobayakawa T, Terabe K, Suzuki M, Sato R, Ohno Y, Hasegawa J, Sugiura T, Ando M, Kuwatsuka Y, Ishiguro N, Imagama S. A randomized controlled trial comparing romosozumab and denosumab in elderly women with primary osteoporosis and knee osteoarthritis. Sci Rep. 2025. DOI: 10.1038/s41598-025-05187-7
  53. Hasegawa J, Suzuki M, Kishimoto K, Sato R, Ohno Y, Sugiura T, Yamamoto H, Terabe K, Asai S, Imagama S. Evaluation of Vertebrae in Patients With Ankylosing Spondylitis Using Hounsfield Unit Values. Int J Rheum Dis. 2025. DOI: 10.1111/1756-185X.70332
  54. Muto S, Takegami Y, Kojima T, Imagama S. Risk factors for screw breakage in Lisfranc joint injuries: A multicenter retrospective study. J Foot Ankle Surg. 2025. DOI: 10.1053/j.jfas.2025.06.001
  55. Tokutake K, Tatebe M, Iwatsuki K, Yoneda H, Nishikawa K, Yamamoto M. Management of Ulnar Wrist Pain Without Ulnar Plus Variance: A Comparative Study of Arthroscopic Triangular Fibrocartilage Complex Repair and Ulnar Shortening Osteotomy. J Hand Surg Asian Pac Vol. 2025. DOI: 10.1142/S2424835525500444
  56. Adachi A, Takegami Y, Nakashima H, Mishima K, Kobayashi K, Imagama S. Comparative clinical outcomes of K-wire fixation versus screw fixation in Lisfranc joint injuries: A multicenter (TRON group) retrospective study. J Foot Ankle Surg. 2025. DOI: 10.1053/j.jfas.2025.05.005
  57. Yamauchi I, Nakashima H, Ito S, Segi N, Ouchida J, Morita Y, Ode Y, Nagatani Y, Okada Y, Takeichi Y, Kagami Y, Tachi H, Ohshima K, Oyama H, Ogura K, Miyairi Y, Oishi R, Morishita K, Shinjo R, Ohara T, Tsuji T, Kanemura T, Imagama S. Preoperative Low Lumbar Hounsfield Units and Global Alignment Predict Postoperative Mechanical Complications After Adult Spinal Deformity Surgery: A Multicenter Retrospective Study. J Clin Med. 2025. DOI: 10.3390/jcm14124267
  58. Ikuta K, Sakai T, Koike H, Fujito T, Urakawa H, Nishida Y, Imagama S. Oncological Outcomes and Postoperative Complications for Localized Soft Tissue Sarcomas of the Extremities and Trunk Wall in Patients Aged 85 Years or Older. Cancers (Basel). 2025. DOI: 10.3390/cancers17121940
  59. Ido H, Seki T, Takegami Y, Osawa Y, Iida H, Nakashima H, Ishizuka S, Hasegawa Y, Imagama S. Serum oxidative stress is associated with the progression of knee osteoarthritis: A 5-year longitudinal cohort in the Yakumo study. Knee. 2025. DOI: 10.1016/j.knee.2025.05.023
  60. Ouchida J, Nakashima H, Ito S, Segi N, Yamauchi I, Imagama S. Recent progress in surgical treatment of cervical spine myelopathy - A narrative review. J Clin Orthop Trauma. 2025. DOI: 10.1016/j.jcot.2025.103074
  61. Ouchida J, Nakashima H, Ito S, Segi N, Yamauchi I, Ode Y, Imagama S. C2 Pelvic Angle as a Predictive Measure for Decompensated Spinopelvic Alignment and Its Impact on Health-Related Quality of Life. Spine (Phila Pa 1976). 2025. DOI: 10.1097/BRS.0000000000005436
  62. Koike H, Ikuta K, Nagano A, Aiba H, Asanuma K, Hamada S, Kozawa E, Izubuchi Y, Kawanami K, Imagama S, Nishida Y. Functional analysis and the importance of ligament reconstruction after soft tissue sarcoma surgery around the knee joint -a Tokai musculoskeletal oncology consortium study. World J Surg Oncol. 2025. DOI: 10.1186/s12957-025-03891-2
  63. Ito S, Imagama S, Nakashima H, Machino M, Sakai T, Aizawa T, Arima H, Hamanaka H, Ishimoto Y, Kato S, Kawaguchi Y, Konishi H, Miyakoshi N, Murakami H, Nagamoto Y, Nakanishi K, Nishida K, Ohba T, Okuda S, Otani K, Suda K, Suzuki N, Takasawa E, Terai H, Tezuka F, Yamato Y, Yukawa Y, Kanemura T, Takaso M, Takahashi H. Nationwide analysis of spinal surgery in Japan from 1994 to 2021. Eur Spine J. 2025. DOI: 10.1007/s00586-025-08999-3
  64. Okada Y, Nakashima H, Ito S, Segi N, Ouchida J, Urasaki T, Imagama S. Preoperative Planning for Cervical Pedicle Screw Placement: Identifying Key Morphological Parameters. Spine Surg Relat Res. 2025. DOI: 10.22603/ssrr.2024-0243
  65. Nakashima H, Matsumoto A, Ito S, Segi N, Ouchida J, Yamauchi I, Morita Y, Imagama S. Impact of T1 Slope Visibility on Cervical Sagittal Alignment: A Comparative Study of Radiographic Parameters According to T1 Slope Visibility. Spine Surg Relat Res. 2025. DOI: 10.22603/ssrr.2024-0253
  66. Ito S, Imagama S, Nakashima H, Machino M, Sakai T, Aizawa T, Arima H, Hamanaka H, Ishimoto Y, Kato S, Kawaguchi Y, Konishi H, Miyakoshi N, Murakami H, Nagamoto Y, Nakanishi K, Nishida K, Ohba T, Okuda S, Otani K, Suda K, Suzuki N, Takasawa E, Terai H, Tezuka F, Yamato Y, Yukawa Y, Kanemura T, Takaso M, Takahashi H. Japanese 2021 nationwide survey on complications from spine surgery. Eur Spine J. 2025. DOI: 10.1007/s00586-025-08981-z
  67. Ouchida J, Nakashima H, Ito S, Segi N, Yamauchi I, Morita Y, Kanemura T, Ohara T, Tsuji T, Shinjo R, Morishita K, Imagama S. Comparative analysis of single-stage versus two-stage fusion surgeries for adult spinal deformity: radiographic outcomes, clinical improvements, and complication rates. Eur Spine J. 2025. DOI: 10.1007/s00586-025-09036-z
  68. Tanaka S, Sakai T, Fukushima W, Takegami Y, Ando W, Sugano N, Imagama S. Temporal Changes in the Age at Diagnosis of Osteonecrosis of the Femoral Head and Potential Associated Factors: A Multicenter Sentinel Monitoring System in Japan. J Arthroplasty. 2025. DOI: 10.1016/j.arth.2025.05.090
  69. Ito R, Tokutake K, Takegami Y, Okui N, Natsume T, Koh S, Tatebe M, Yamamoto M. Primary nerve exploration is required in more than 10% of complete motor nerve paralysis cases associated with Gartland type III paediatric supracondylar humerus fractures : a multicentre retrospective study. Bone Jt Open. 2025. DOI: 10.1302/2633-1462.66.BJO-2025-0020.R1
  70. Ido H, Osawa Y, Takegami Y, Funahashi H, Asamoto T, Imagama S. Comparison of the Progression Rate of Femoral Head Collapse in Japanese Investigation Committee Classification Types B1 and B2 of Osteonecrosis of the Femoral Head. J Arthroplasty. 2025. DOI: 10.1016/j.arth.2025.05.055
  71. Otaka K, Sakai T, Fukushima W, Takegami Y, Ando W, Imagama S, Sugano N. Increasing Prevalence and Risk Factors for Multifocal Osteonecrosis in Patients Who Have Corticosteroid-Associated Osteonecrosis of the Femoral Head: A 15-Year Multicenter Study. J Arthroplasty. 2025. DOI: 10.1016/j.arth.2025.05.043
  72. Kosugiyama H, Asai S, Terabe K, Kobayakawa T, Yoshioka Y, Watanabe T, Kojima T, Sobue Y, Kato T, Fujibayashi T, Hirano Y, Nishiume T, Kato M, Kanayama Y, Takemoto T, Hanabayashi M, Matsubara H, Suzuki M, Sato R, Hasegawa J, Ohno Y, Sugiura T, Takahashi N, Imagama S. Comparable Clinical Effectiveness of Baricitinib and Filgotinib in Patients With Rheumatoid Arthritis. Int J Rheum Dis. 2025. DOI: 10.1111/1756-185X.70288
  73. Ito K, Nishida Y, Ikuta K, Urakawa H, Sakai T, Koike H, Nishida K, Imagama S. Clinical factors associated with valgus knee deformities in patients with multiple osteochondromas. Medicine (Baltimore). 2025. DOI: 10.1097/MD.0000000000042359
  74. Oishi R, Segi N, Okazaki M, Ito S, Ouchida J, Yamauchi I, Seki T, Takegami Y, Ishizuka S, Hashizume A, Hasegawa Y, Imagama S, Nakashima H. Longitudinal transitions in frailty and health-related quality of life investigated by a 5-year community study. Sci Rep. 2025. DOI: 10.1038/s41598-025-99843-7
  75. Takegami Y, Osawa Y, Funahashi H, Asamoto T, Ido H, Otaka K, Tanaka S, Asai H, Yokoi H, Imagama S. One-Year Survival and Postoperative Complications in Older Patients with Intertrochanteric Fractures: Association with Polypharmacy-A Multicenter Retrospective Cohort Study. Drugs Aging. 2025. DOI: 10.1007/s40266-025-01194-5
  76. Sobue Y, Suzuki M, Ohashi Y, Sato R, Ohno Y, Hasegawa J, Sugiura T, Terabe K, Asai S, Imagama S. Association between frailty and oral function in rheumatoid arthritis patients: A multi-center, observational study. Arch Rheumatol. 2025. DOI: 10.46497/ArchRheumatol.2025.11039
  77. Yoshida A, Iwatsuki K, Shinohara T, Hirata H. Exploring Subtypes Based on Depression and Anxiety in Preoperative Patients With Carpal Tunnel Syndrome: A Two-Step Cluster Analysis. Cureus. 2025. DOI: 10.7759/cureus.80928
  78. Ito H, Takegami Y, Nakashima H, Mishima K, Yamauchi K, Imagama S. Impact of Fixation Length for Single-Level Spinal Metastasis Surgery in the Elderly: A Multicenter Study. Cureus. 2025. DOI: 10.7759/cureus.80886
  79. Sawamura K, Kitoh H, Kamiya Y, Mishima K, Matsushita M, Imagama S. Changes in the Alignment of the Spine and Lower Limb in Children With Achondroplasia Treated With Vosoritide: A Single-center, 1-year Follow-up Prospective Study. J Pediatr Orthop. 2025. DOI: 10.1097/BPO.0000000000002980
  80. Segi N, Nakashima H, Funaba M, Hashimoto J, Kawabata S, Takahashi M, Yoshida G, Ushirozako H, Kurosu K, Shigematsu H, Takatani T, Morito S, Yamada K, Iwasaki H, Fujiwara Y, Yasuda A, Ando M, Taniguchi S, Wada K, Tadokoro N, Kobayashi K, Yamamoto N, Nakanishi K, Kanchiku T, Takeshita K, Matsuyama Y, Imagama S. Characteristics of Poor Recordability of Intraoperative Neurophysiological Monitoring during Metastatic Spinal Tumor Surgery: A Multicenter Study. Spine Surg Relat Res. 2025. DOI: 10.22603/ssrr.2024-0260
  81. Ito S, Nakashima H, Segi N, Ouchida J, Yamauchi I, Hirai T, Oda M, Mori K, Yamazaki M, Yoshii T, Imagama S. Development of a YOLOv3-Based Model for Automated Detection of Thoracic Ossification of the Posterior Longitudinal Ligament and the Ligamentum Flavum on Plain Radiographs. J Clin Med. 2025. DOI: 10.3390/jcm14072389
  82. Mizuno T, Ishizuka S, Kurokouchi K, Yasui J, Oba H, Sakaguchi T, Takahashi S, Imagama S. Etiology and effects of cyclops lesions in double-bundle anterior cruciate ligament reconstruction: A case-control study. J Orthop. 2025. DOI: 10.1016/j.jor.2025.03.010
  83. Ouchida J, Morita Y, Ito S, Segi N, Yamauchi I, Kanemura T, Ohara T, Tsuji T, Shinjyo R, Imagama S, Nakashima H. Impact of Paraspinal Muscle Degeneration on Surgical Outcomes and Radiographical Sagittal Alignment in Adult Spinal Deformity: A Multicenter Study. Neurospine. 2025. DOI: 10.14245/ns.2449174.587
  84. Asai S, Kojima T, Ishikawa H, Miyake N, Kodera M, Hasegawa H, Sobue Y, Kanayama Y, Shimada H, Hirano Y, Hidaka T, Fujibayashi T, Matsumoto T, Kobayakawa T, Yasuoka H, Kato T, Hanabayashi M, Kaneko Y, Tada M, Murata K, Misaki K, Ando M, Kuwatsuka Y, Suzuki M, Terabe K, Imagama S. Discontinuation vs. continuation of concomitant methotrexate in patients with rheumatoid arthritis on certolizumab pegol: results from a randomised, controlled trial. Arthritis Res Ther. 2025. DOI: 10.1186/s13075-025-03548-1
  85. Segi N, Nakashima H, Ito S, Ouchida J, Yamauchi I, Matsumoto T, Kanbara S, Ito K, Imagama S. Response to Letter to the Editor Regarding the Article Entitled \"Trabecular Bone Remodeling After Posterior Lumbar Interbody Fusion: Comparison of the Osseointegration in Three-Dimensional Porous Titanium Cages and Polyether-Ether-Ketone Cages\" by Segi et al. Global Spine J. 2025. DOI: 10.1177/21925682251332558
  86. Nagatani Y, Nakashima H, Kanemura T, Tsushima M, Tomita H, Morishita K, Oyama H, Ito S, Segi N, Ouchida J, Yamauchi I, Ode Y, Okada Y, Imagama S. Clinical Outcomes Associated with Screw Loosening in S2 Alar-Iliac Fixation in Adult Spinal Deformity. J Clin Med. 2025. DOI: 10.3390/jcm14061881
  87. Yokoi H, Osawa Y, Takegami Y, Ozawa Y, Funahashi H, Imagama S. Direction of pelvic obliquity after total hip arthroplasty for dysplastic hip osteoarthritis: a retrospective observational study. Arch Orthop Trauma Surg. 2025. DOI: 10.1007/s00402-025-05829-5
  88. Yoneda H, Curley J, Iwatsuki K, Saeki M, Takahashi N, Yamamoto M. Impact of COVID-19 Pandemic on Hand Surgery Volume in Japan. J Clin Med. 2025. DOI: 10.3390/jcm14051518
  89. Muto S, Takegami Y, Nakashima H, Mishima K, Kumagai H, Imagama S. Is routine implant removal necessary after open reduction internal fixation of Lisfranc injuries? Comparing functional outcomes of routine and on-demand removal: A multicenter study. Injury. 2025. DOI: 10.1016/j.injury.2025.112240
  90. Kishimoto K, Asai S, Suzuki M, Sato R, Hasegawa J, Ohno Y, Terabe K, Imagama S. Association of spinal ankylosis with spinal mobility and functional impairment in radiographic axial spondyloarthritis: A computed tomography study. Mod Rheumatol. 2025. DOI: 10.1093/mr/roaf022
  91. Nakashima H, Kawakami N, Ito S, Segi N, Ouchida J, Yamauchi I, Kanemura T, Imagama S. Pelvic ring ratio: a novel indicator of comprehensive pelvic alignment assessment. Asian Spine J. 2025. DOI: 10.31616/asj.2024.0447
  92. Tanaka S, Osawa Y, Takegami Y, Funahashi H, Ido H, Asamoto T, Imagama S. Computed tomography-based navigation versus accelerometer-based portable navigation in total hip arthroplasty for dysplastic hip osteoarthritis. Eur J Orthop Surg Traumatol. 2025. DOI: 10.1007/s00590-025-04188-6
  93. Fujita A, Oyama S, Tatebe M, Shimoda S, Tokutake K, Yamamoto M, Hirata H. Eyes and movement differences in unconscious state during microscopic procedures. Sci Rep. 2025. DOI: 10.1038/s41598-025-88647-4
  94. Iida H, Kawai-Takaishi M, Miyagawa Y, Takegami Y, Uezumi A, Honda T, Imagama S, Hosoyama T. PDZRN3 regulates adipogenesis of mesenchymal progenitors in muscle. Regen Ther. 2025. DOI: 10.1016/j.reth.2025.01.018
  95. Otaka K, Osawa Y, Takegami Y, Iida H, Funahashi H, Imagama S. Fatty infiltration of periarticular muscles in patients with osteonecrosis of the femoral head. Int Orthop. 2025. DOI: 10.1007/s00264-025-06457-9
  96. Segi N, Nakashima H, Ito S, Ouchida J, Oishi R, Yamauchi I, Miyairi Y, Morita Y, Tsushima M, Tomita H, Morishita K, Ohshima K, Kanemura T, Imagama S. Trabecular Bone Remodeling after Lateral Lumbar Interbody Fusion: Indirect Findings for Stress Transmission between Vertebrae after Spinal Fusion Surgery. Spine Surg Relat Res. 2025. DOI: 10.22603/ssrr.2024-0054
  97. Ito S, Nakashima H, Segi N, Yokogawa N, Sasagawa T, Funayama T, Eto F, Yamaji A, Watanabe K, Nori S, Takeda K, Furuya T, Yunde A, Nakajima H, Yamada T, Hasegawa T, Terashima Y, Hirota R, Suzuki H, Imajo Y, Ikegami S, Uehara M, Tonomura H, Sakata M, Hashimoto K, Onoda Y, Kawaguchi K, Haruta Y, Suzuki N, Kato K, Uei H, Sawada H, Nakanishi K, Misaki K, Terai H, Tamai K, Kuroda A, Inoue G, Kakutani K, Kakiuchi Y, Kiyasu K, Tominaga H, Tokumoto H, Iizuka Y, Takasawa E, Akeda K, Takegami N, Funao H, Oshima Y, Kaito T, Sakai D, Yoshii T, Ohba T, Otsuki B, Seki S, Miyazaki M, Ishihara M, Oda M, Okada S, Imagama S, Kato S. A deep learning-based prediction model for prognosis of cervical spine injury: a Japanese multicenter survey. Eur Spine J. 2025. DOI: 10.1007/s00586-025-08708-0
  98. Asano K, Iwatsuki K, Yokoyama H, Mabuchi M, Yamamoto M. Patient-specific factors associated with conservative treatment failure in de Quervain tenosynovitis. J Clin Orthop Trauma. 2025. DOI: 10.1016/j.jcot.2025.102923
  99. Ohshima K, Nakashima H, Segi N, Ito S, Ouchida J, Takegami Y, Ishizuka S, Yamauchi I, Hasegawa Y, Murotani K, Imagama S. Impact of diffuse idiopathic skeletal hyperostosis on quality of life and locomotive syndrome in community-dwelling older adults: the Yakumo study. Sci Rep. 2025. DOI: 10.1038/s41598-025-87878-9
  100. Oyama S, Iwase H, Yoneda H, Yokota H, Hirata H, Yamamoto M. Insights and trends review: Use of extended reality (xR) in hand surgery. J Hand Surg Eur Vol. 2025. DOI: 10.1177/17531934241313208
  101. Koike H, Ikuta K, Urakawa H, Sakai T, Fujito T, Nishida Y, Imagama S. Implant failure of the Compress prosthesis: a case report. J Med Case Rep. 2025. DOI: 10.1186/s13256-024-05012-1
  102. Nishida Y, Nonobe N, Kidokoro H, Kato T, Takeichi T, Ikuta K, Urakawa H, Sakai T, Koike H, Fujito T, Imagama S. Selumetinib for symptomatic, inoperable plexiform neurofibromas in pediatric patients with neurofibromatosis type 1: the first single-center real-world case series in Japan. Jpn J Clin Oncol. 2025. DOI: 10.1093/jjco/hyae184
  103. Tsuchihashi A, Natsume T, Yamamoto M. Impact of Antithrombotic Drug Continuation on Postoperative Outcomes in Patients with Carpal Tunnel Syndrome: A Randomised, Open-Label, Parallel Group Trial. J Hand Surg Asian Pac Vol. 2025. DOI: 10.1142/S2424835525500146
  104. Otaka K, Osawa Y, Takegami Y, Funahashi H, Imagama S. Discrepancy between radiography and magnetic resonance imaging in Japanese Investigation Committee classification type C osteonecrosis of the femoral head. Int Orthop. 2025. DOI: 10.1007/s00264-024-06396-x
  105. Yamauchi I, Nakashima H, Ito S, Segi N, Ouchida J, Morita Y, Ode Y, Nagatani Y, Okada Y, Tauchi R, Ohara T, Kawakami N, Imagama S. Outcomes following instrumentation removal after posterior corrective fixation in adolescent idiopathic scoliosis. Eur Spine J. 2025. DOI: 10.1007/s00586-024-08519-9
  106. Ouchida J, Nakashima H, Ohara T, Machino M, Ito S, Segi N, Yamauchi I, Imagama S. Patterns of sitting spinal alignment in non-ambulatory scoliosis patients with paraplegia: an observational study. Eur Spine J. 2025. DOI: 10.1007/s00586-024-08584-0
  107. Ozawa Y, Osawa Y, Seki T, Takegami Y, Iida H, Funahashi H, Imagama S. Total Hip Arthroplasty Using the Conjoined Tendon-Preserving Posterior Approach: The Modified Posterior Approach with a Minimum of 2-Year Follow-Up. Orthop Surg. 2025. DOI: 10.1111/os.14194
  108. Kagami Y, Nakashima H, Segi N, Ito S, Ouchida J, Ogura K, Shinjo R, Imagama S. Incremental cost-effectiveness ratio between titanium plate and hydroxyapatite block spacers in cervical laminoplasty for degenerative cervical myelopathy. J Orthop Sci. 2025. DOI: 10.1016/j.jos.2024.10.003
  109. Sawamura K, Matsushita M, Esaki R, Mishima K, Kamiya Y, Ohno K, Kitoh H, Imagama S. Meclozine and growth hormone ameliorate bone length and quality in experimental models of achondroplasia. J Bone Miner Metab. 2025. DOI: 10.1007/s00774-024-01563-x
  110. Segi N, Nakashima H, Ito S, Ouchida J, Shiratani Y, Shimizu T, Suzuki A, Terai H, Kakutani K, Kanda Y, Tominaga H, Kawamura I, Ishihara M, Paku M, Takahashi Y, Funaba M, Funayama T, Nakajima H, Akeda K, Hirai T, Inoue H, Nakanishi K, Funao H, Oshigiri T, Otsuki B, Kobayakawa K, Tanishima S, Hashimoto K, Iimura T, Sawada H, Uotani K, Manabe H, Iwai C, Yamabe D, Hiyama A, Seki S, Goto Y, Miyazaki M, Watanabe K, Nakamae T, Kaito T, Nagoshi N, Kato S, Watanabe K, Imagama S, Inoue G, Furuya T. Effects of Palliative Surgical Treatment for Spinal Metastases on the Patient's Quality of Life With a Focus on the Segment of the Metastasis: A Prospective Multicenter Study. Global Spine J. 2025. DOI: 10.1177/21925682241297948
  111. Suzuki M, Takegami Y, Tokutake K, Nakasima H, Mishima K, Kumagai H, Imagama S. Elderly trochanteric fracture outcomes: Unveiling the risks of excessive postoperative sliding - A retrospective multicenter (TRON group) investigation. J Orthop Sci. 2025. DOI: 10.1016/j.jos.2024.09.003
  112. Kurahashi S, Takegami Y, Tokutake K, Nakashima H, Mishima K, Yamauchi K, Imagama S. Risk factors for nonunion in femoral neck fracture patients with internal fixation: A multicenter (TRON group) retrospective study. J Orthop Sci. 2025. DOI: 10.1016/j.jos.2024.09.002
  113. Suzuki M, Asai S, Ohashi Y, Sobue Y, Ishikawa H, Terabe K, Sato R, Kosugiyama H, Hasegawa J, Ohno Y, Sugiura T, Imagama S. Prevalence of social frailty in patients with rheumatoid arthritis: Data from a multicentre observational study (T-FLAG study). Mod Rheumatol. 2025. DOI: 10.1093/mr/roae078
  114. Yoneda H, Curley J, Yamamoto M, Hirata H. Impact of Collagenase Injection on Dupuytren Disease Treatment in Japan: A Comprehensive Survey of Trends. Ann Plast Surg. 2025. DOI: 10.1097/SAP.0000000000004076
  115. Ogura K, Takegami Y, Kuwahara Y, Tokutake K, Nakashima R, Yamamoto S, Naito K, Kasai T, Makida K, Imagama S. Comparison of conjoined tendon-preserving posterior approach and conventional posterolateral approach in hemiarthroplasty for femoral neck fracture in the elderly: A multicenter (TRON group) retrospective study. J Orthop Sci. 2025. DOI: 10.1016/j.jos.2024.05.003
  116. Segi N, Nakashima H, Ito S, Ouchida J, Oishi R, Yamauchi I, Miyairi Y, Morita Y, Matsumoto T, Kanbara S, Ito K, Imagama S. Trabecular Bone Remodeling after Posterior Lumbar Interbody Fusion: Comparison of the Osseointegration in Three-Dimensional Porous Titanium Cages and Polyether-Ether-Ketone Cages. Global Spine J. 2025. DOI: 10.1177/21925682241255686
  117. Kimura Y, Asami Y, Tokutake K, Takegami Y, Oshima K, Ishihara N, Imagama S. Diaphyseal forearm fracture management in adolescent patients from 2011 to 2020: A multicenter study of surgery and regional anesthesia trends. J Orthop Sci. 2025. DOI: 10.1016/j.jos.2024.03.009
  118. Murase F, Takegami Y, Tokutake K, Oyama H, Arakawa O, Takatsu T, Nakashima H, Mishima K, Imagama S. Fracture of the patella involving inferior pole is associated with postoperative patella baja - A retrospective multicenter study. J Orthop Sci. 2025. DOI: 10.1016/j.jos.2024.03.008
  119. Sawamura K, Kitoh H, Matsushita M, Mishima K, Kamiya Y, Imagama S. Quality of life in adult patients with developmental dysplasia of the hip who were treated for hip dislocation during childhood. J Pediatr Orthop B. 2025. DOI: 10.1097/BPB.0000000000001173
  120. Ido H, Takegami Y, Osawa Y, Okamoto M, Iida H, Imagama S. Risk factors for intraoperative femoral fractures in cementless bipolar hip arthroplasty for femoral neck fracture in multicenter: The TRON group study. J Orthop Sci. 2025. DOI: 10.1016/j.jos.2024.01.005
  121. Sugiura H, Tatebe M, Yoneda H, Nishizuka T, Morita A, Yamamoto M. A Small Ratio of Proximal to Distal Bone Fragments Is a Risk Factor for Scaphoid Nonunion: A Volumetric Analysis of Preoperative CT. J Wrist Surg. 2025. DOI: 10.1055/s-0044-1779286
  122. Segi N, Nakashima H, Ito S, Yokogawa N, Sasagawa T, Watanabe K, Nori S, Funayama T, Eto F, Nakajima H, Terashima Y, Hirota R, Hashimoto K, Onoda Y, Furuya T, Yunde A, Ikegami S, Uehara M, Suzuki H, Imajo Y, Uei H, Sawada H, Kawaguchi K, Nakanishi K, Suzuki N, Oshima Y, Hasegawa T, Iizuka Y, Tonomura H, Terai H, Akeda K, Seki S, Ishihara M, Inoue G, Funao H, Yoshii T, Kaito T, Kiyasu K, Tominaga H, Kakutani K, Sakai D, Ohba T, Otsuki B, Miyazaki M, Murotani K, Okada S, Imagama S, Kato S. Early Versus Delayed Surgery for Elderly Traumatic Cervical Spinal Injury: A Nationwide Multicenter Study in Japan. Global Spine J. 2025. DOI: 10.1177/21925682241227430
  123. Shimamoto Y, Tokutake K, Takegami Y, Asami Y, Sato K, Ueno H, Nakano T, Fujii S, Okui N, Imagama S. Comparative Outcomes of Anterior and Posterior Plating for Distal-Third Humerus Shaft Fractures. J Hand Surg Am. 2025. DOI: 10.1016/j.jhsa.2023.07.014
  124. Segi N, Nakashima H, Machino M, Ito S, Yokogawa N, Sasagawa T, Funayama T, Eto F, Yamaji A, Watanabe K, Nori S, Takeda K, Furuya T, Yunde A, Nakajima H, Yamada T, Hasegawa T, Terashima Y, Hirota R, Suzuki H, Imajo Y, Ikegami S, Uehara M, Tonomura H, Sakata M, Hashimoto K, Onoda Y, Kawaguchi K, Haruta Y, Suzuki N, Kato K, Uei H, Sawada H, Nakanishi K, Misaki K, Terai H, Tamai K, Shirasawa E, Inoue G, Kakutani K, Kakiuchi Y, Iizuka Y, Takasawa E, Akeda K, Takegami N, Kiyasu K, Tominaga H, Tokumoto H, Funao H, Oshima Y, Yoshii T, Kaito T, Sakai D, Ohba T, Seki S, Otsuki B, Ishihara M, Miyazaki M, Okada S, Imagama S, Kato S. Prognosis of Cervical Diffuse Idiopathic Skeletal Hyperostosis-Related Spine Injuries in Elderly Patients: Analyses of Both Fracture and Spinal Cord Injury Without Fracture. Global Spine J. 2025. DOI: 10.1177/21925682231186757

• 2024

  1. Nakashima H, Matsumoto A, Ito S, Segi N, Ouchida J, Yamauchi I, Morita Y, Imagama S. Impact of T1 Slope Visibility on Cervical Sagittal Alignment: A Comparative Study of Radiographic Parameters According to T1 Slope Visibility. Spine Surg Relat Res. 2025. DOI: 10.22603/ssrr.2024-0253
  2. Shigematsu H, Yoshida G, Ushirozako H, Kurosu K, Tadokoro N, Funaba M, Kawabata S, Hashimoto J, Ando M, Taniguchi S, Takahashi M, Segi N, Nakashima H, Imagama S, Morito S, Yamada K, Takatani T, Kanchiku T, Fujiwara Y, Iwasaki H, Wada K, Yamamoto N, Kobayashi K, Yasuda A, Nakanishi K, Tanaka Y, Matsuyama Y, Takeshita K. Does Somatosensory-Evoked Potential Simultaneously Decrease with Transcranial Motor-Evoked Potential Alarm? A Multicenter Study by the Monitoring Committee of the Japanese Society for Spine Surgery and Related Research. Spine Surg Relat Res. 2025. DOI: 10.22603/ssrr.2024-0229
  3. Segi N, Nakashima H, Funaba M, Hashimoto J, Kawabata S, Takahashi M, Yoshida G, Ushirozako H, Kurosu K, Shigematsu H, Takatani T, Morito S, Yamada K, Iwasaki H, Fujiwara Y, Yasuda A, Ando M, Taniguchi S, Wada K, Tadokoro N, Kobayashi K, Yamamoto N, Nakanishi K, Kanchiku T, Takeshita K, Matsuyama Y, Imagama S. Characteristics of Poor Recordability of Intraoperative Neurophysiological Monitoring during Metastatic Spinal Tumor Surgery: A Multicenter Study. Spine Surg Relat Res. 2025. DOI: 10.22603/ssrr.2024-0260
  4. Segi N, Nakashima H, Ito S, Ouchida J, Oishi R, Yamauchi I, Miyairi Y, Morita Y, Tsushima M, Tomita H, Morishita K, Ohshima K, Kanemura T, Imagama S. Trabecular Bone Remodeling after Lateral Lumbar Interbody Fusion: Indirect Findings for Stress Transmission between Vertebrae after Spinal Fusion Surgery. Spine Surg Relat Res. 2025. DOI: 10.22603/ssrr.2024-0054
  5. Funahashi H, Osawa Y, Takegami Y, Ozawa Y, Ido H, Asamoto T, Imagama S. Acetabular osteophyte formation in dysplastic hip osteoarthritis. BMC Musculoskelet Disord. 2024. DOI: 10.1186/s12891-024-08211-5
  6. Tsuchihashi A, Natsume T, Yamamoto M. Impact of Antithrombotic Drug Continuation on Postoperative Outcomes in Patients with Carpal Tunnel Syndrome: A Randomised, Open-Label, Parallel Group Trial. J Hand Surg Asian Pac Vol. 2025. DOI: 10.1142/S2424835525500146
  7. Otaka K, Osawa Y, Takegami Y, Funahashi H, Imagama S. Discrepancy between radiography and magnetic resonance imaging in Japanese Investigation Committee classification type C osteonecrosis of the femoral head. Int Orthop. 2025. DOI: 10.1007/s00264-024-06396-x
  8. Mishima K, Kitoh H, Shiraki A, Sawamura K, Kamiya Y, Matsushita M, Imagama S. Generalized Epileptic Seizures in Fibrodysplasia Ossificans Progressiva Harboring a Recurrent Heterozygous Variant of the ACVR1 Gene (R206H). Case Rep Genet. 2024. DOI: 10.1155/crig/9569275
  9. Segi N, Nakashima H, Ito S, Ouchida J, Yokogawa N, Sasagawa T, Furuya T, Yunde A, Funayama T, Eto F, Watanabe K, Nori S, Ikegami S, Uehara M, Hashimoto K, Onoda Y, Nakajima H, Suzuki H, Imajo Y, Yamada T, Hasegawa T, Kawaguchi K, Haruta Y, Terashima Y, Hirota R, Tonomura H, Sakata M, Iizuka Y, Uei H, Suzuki N, Akeda K, Tominaga H, Seki S, Oshima Y, Kaito T, Otsuki B, Nakanishi K, Kakutani K, Funao H, Yoshii T, Sakai D, Ohba T, Miyazaki M, Terai H, Inoue G, Okada S, Imagama S, Kato S. Comparative Analysis of Characteristics of Lower- and Mid-Cervical Spine Injuries in the Elderly. Spine Surg Relat Res. 2024. DOI: 10.22603/ssrr.2024-0030
  10. Morita Y, Nakashima H, Segi N, Ito S, Ouchida J, Oishi R, Yamauchi I, Miyairi Y, Tsushima M, Ito K, Tomita H, Morishita K, Kanemura T, Imagama S. Indirect Decompression in Vertebral Reconstruction for Osteoporotic Vertebral Fractures with Neurological Symptoms: A Preliminary Case Series. Spine Surg Relat Res. 2024. DOI: 10.22603/ssrr.2024-0013
  11. Yamauchi I, Nakashima H, Ito S, Segi N, Ouchida J, Morita Y, Ode Y, Nagatani Y, Okada Y, Tauchi R, Ohara T, Kawakami N, Imagama S. Outcomes following instrumentation removal after posterior corrective fixation in adolescent idiopathic scoliosis. Eur Spine J. 2025. DOI: 10.1007/s00586-024-08519-9
  12. Tanaka S, Osawa Y, Takegami Y, Okui N, Yamauchi KI, Aoki Y, Imagama S. Changes of hip fracture in older patients before and after the COVID-19 pandemic: a retrospective multicentre study in Japan. BMC Musculoskelet Disord. 2024. DOI: 10.1186/s12891-024-08050-4
  13. Ouchida J, Nakashima H, Ohara T, Machino M, Ito S, Segi N, Yamauchi I, Imagama S. Patterns of sitting spinal alignment in non-ambulatory scoliosis patients with paraplegia: an observational study. Eur Spine J. 2025. DOI: 10.1007/s00586-024-08584-0
  14. Ozawa Y, Osawa Y, Seki T, Takegami Y, Iida H, Funahashi H, Imagama S. Total Hip Arthroplasty Using the Conjoined Tendon-Preserving Posterior Approach: The Modified Posterior Approach with a Minimum of 2-Year Follow-Up. Orthop Surg. 2025. DOI: 10.1111/os.14194
  15. Kagami Y, Nakashima H, Segi N, Ito S, Ouchida J, Ogura K, Shinjo R, Imagama S. Incremental cost-effectiveness ratio between titanium plate and hydroxyapatite block spacers in cervical laminoplasty for degenerative cervical myelopathy. J Orthop Sci. 2025. DOI: 10.1016/j.jos.2024.10.003
  16. Asai S, Takahashi N, Terabe K, Yoshioka Y, Kojima T, Kobayakawa T, Sobue Y, Watanabe T, Hirano Y, Kanayama Y, Kato T, Hanabayashi M, Suzuki M, Imagama S. Clinical effectiveness of baricitinib and abatacept in patients with rheumatoid arthritis. Int J Rheum Dis. 2024. DOI: 10.1111/1756-185X.15414
  17. Sawamura K, Matsushita M, Esaki R, Mishima K, Kamiya Y, Ohno K, Kitoh H, Imagama S. Meclozine and growth hormone ameliorate bone length and quality in experimental models of achondroplasia. J Bone Miner Metab. 2025. DOI: 10.1007/s00774-024-01563-x
  18. Nishida Y, Ito K, Sakai T, Kinoshita F, Kuwatsuka Y, Kinoshita S, Imagama S. Efficacy and Safety of Auranofin for Progressive Desmoid-Type Fibromatosis: The Study Protocol of an Open-Label Phase II Trial. Cureus. 2024. DOI: 10.7759/cureus.71033
  19. Segi N, Nakashima H, Ito S, Ouchida J, Shiratani Y, Shimizu T, Suzuki A, Terai H, Kakutani K, Kanda Y, Tominaga H, Kawamura I, Ishihara M, Paku M, Takahashi Y, Funaba M, Funayama T, Nakajima H, Akeda K, Hirai T, Inoue H, Nakanishi K, Funao H, Oshigiri T, Otsuki B, Kobayakawa K, Tanishima S, Hashimoto K, Iimura T, Sawada H, Uotani K, Manabe H, Iwai C, Yamabe D, Hiyama A, Seki S, Goto Y, Miyazaki M, Watanabe K, Nakamae T, Kaito T, Nagoshi N, Kato S, Watanabe K, Imagama S, Inoue G, Furuya T. Effects of Palliative Surgical Treatment for Spinal Metastases on the Patient's Quality of Life With a Focus on the Segment of the Metastasis: A Prospective Multicenter Study. Global Spine J. 2025. DOI: 10.1177/21925682241297948
  20. Tanaka S, Osawa Y, Takegami Y, Ozawa Y, Imagama S. Radiographic factors affecting contralateral knee alignment in patients with dysplastic hip osteoarthritis. Knee. 2024. DOI: 10.1016/j.knee.2024.09.014
  21. Sobue Y, Suzuki M, Ohashi Y, Sato R, Kosugiyama H, Ohno Y, Hasegawa J, Sugiura T, Terabe K, Asai S, Imagama S. Verification of grip strength as an evaluation tool for locomotive syndrome in rheumatoid arthritis. Osteoporos Sarcopenia. 2024. DOI: 10.1016/j.afos.2024.07.001
  22. Segi N, Nakashima H, Ito S, Ouchida J, Yokogawa N, Sasagawa T, Funayama T, Eto F, Watanabe K, Nori S, Furuya T, Yunde A, Terashima Y, Hirota R, Nakajima H, Yamada T, Hasegawa T, Kawaguchi K, Haruta Y, Hashimoto K, Onoda Y, Nakanishi K, Misaki K, Ikegami S, Uehara M, Suzuki H, Imajo Y, Uei H, Sawada H, Terai H, Tamai K, Kuroda A, Inoue G, Suzuki N, Kato K, Akeda K, Takegami N, Iizuka Y, Oshima Y, Tonomura H, Kiyasu K, Funao H, Yoshii T, Ishihara M, Kaito T, Seki S, Kakutani K, Tominaga H, Ohba T, Sakai D, Otsuki B, Miyazaki M, Okada S, Imagama S, Kato S. Low Nutrition before Injury Is a Risk Factor for Dysphagia in Older Patients with Cervical Spinal Cord Injury: Based on a Multicenter Data of 707 Patients. Spine Surg Relat Res. 2024. DOI: 10.22603/ssrr.2023-0227
  23. Suzuki M, Takegami Y, Tokutake K, Nakasima H, Mishima K, Kumagai H, Imagama S. Elderly trochanteric fracture outcomes: Unveiling the risks of excessive postoperative sliding - A retrospective multicenter (TRON group) investigation. J Orthop Sci. 2025. DOI: 10.1016/j.jos.2024.09.003
  24. Kurahashi S, Takegami Y, Tokutake K, Nakashima H, Mishima K, Yamauchi K, Imagama S. Risk factors for nonunion in femoral neck fracture patients with internal fixation: A multicenter (TRON group) retrospective study. J Orthop Sci. 2025. DOI: 10.1016/j.jos.2024.09.002
  25. Morishita K, Nakashima H, Machino M, Ito S, Segi N, Miyairi Y, Morita Y, Imagama S. Adenosine triphosphate release inhibitors targeting pannexin1 improve recovery after spinal cord injury. Nagoya J Med Sci. 2024. DOI: 10.18999/nagjms.86.3.392
  26. Kagami Y, Nakashima H, Segi N, Ito S, Ouchida J, Shinjo R, Imagama S. A novel technique for C1-C2 posterior screw insertion using patient-specific guides created by CT-based 3D printing. Nagoya J Med Sci. 2024. DOI: 10.18999/nagjms.86.3.487
  27. Okamoto M, Takegami Y, Osawa Y, Tanaka S, Nobori T, Imagama S. Accelerometer-based portable navigation system shows no superior accuracy over pelvic alignment guide for acetabular cup placement in total hip arthroplasty in lateral decubitus position. Arch Orthop Trauma Surg. 2024. DOI: 10.1007/s00402-024-05571-4
  28. Sano M, Iwatsuki K, Hirata H, Hoshiyama M. Imbalance in positive and negative acceleration ratio of alpha oscillation in patients with complex regional pain syndrome. Heliyon. 2024. DOI: 10.1016/j.heliyon.2024.e36463
  29. Sobue Y, Suzuki M, Ohashi Y, Sato R, Kosugiyama H, Ohno Y, Hasegawa J, Sugiura T, Terabe K, Asai S, Imagama S. Association between sarcopenia and locomotive syndrome in rheumatoid arthritis patients: A multicenter observational study (T-FLAG). Int J Rheum Dis. 2024. DOI: 10.1111/1756-185X.15321
  30. Asami Y, Tokutake K, Kurimoto S, Saeki S, Yamamoto M, Hirata H. Transplantation of embryonic spinal motor neurons into peripheral nerves enables functional reconstruction of a denervated diaphragm. Neuroscience. 2024. DOI: 10.1016/j.neuroscience.2024.08.039
  31. Yokoi H, Takegami Y, Ochiai S, Miyachi T, Urasaki T, Imagama S. Free bone fragments are associated with the development of heterotopic ossification after hemiarthroplasty for femoral neck fracture: a retrospective observational study. Eur J Orthop Surg Traumatol. 2024. DOI: 10.1007/s00590-024-04083-6
  32. Kishimoto K, Asai S, Suzuki M, Sato R, Hasegawa J, Terabe K, Imagama S. Clinical features of juvenile onset ankylosing spondylitis in Japanese patients. Mod Rheumatol. 2024. DOI: 10.1093/mr/roae065
  33. Yoneda H, Iwatsuki K, Saeki M, Murayama A, Takahashi N, Yamamoto M, Hirata H. Quantitative Measurement of Rotation in Phalangeal Fracture Malunion Using Computed Tomography Imaging-\"Linkage Simulation\". Diagnostics (Basel). 2024. DOI: 10.3390/diagnostics14161818
  34. Fukui J, Matsui Y, Mizuno T, Watanabe T, Takemura M, Ishizuka S, Imagama S, Arai H. Comparison of gait analysis before and after unilateral total knee arthroplasty for knee osteoarthritis. J Orthop Surg Res. 2024. DOI: 10.1186/s13018-024-04891-w
  35. Ozawa Y, Osawa Y, Takegami Y, Iida H, Takemoto G, Imagama S. Risk factors for residual pelvic obliquity one year after total hip arthroplasty. Eur J Orthop Surg Traumatol. 2024. DOI: 10.1007/s00590-024-04060-z
  36. Yoneda H, Curley J, Yamamoto M, Hirata H. Impact of Collagenase Injection on Dupuytren Disease Treatment in Japan: A Comprehensive Survey of Trends. Ann Plast Surg. 2025. DOI: 10.1097/SAP.0000000000004076
  37. Ozawa Y, Osawa Y, Takegami Y, Funahashi H, Tanaka S, Imagama S. Characteristics of pelvic obliquity in dysplastic hip osteoarthritis. Arch Orthop Trauma Surg. 2024. DOI: 10.1007/s00402-024-05476-2
  38. Ito S, Nakashima H, Segi N, Ouchida J, Oishi R, Yamauchi I, Miyairi Y, Morita Y, Ode Y, Imagama S. Ten-Year Follow-up of Posterior Decompression and Fusion Surgery for Thoracic Ossification of the Posterior Longitudinal Ligament. J Bone Joint Surg Am. 2024. DOI: 10.2106/JBJS.23.01475
  39. Mishima K, Kamiya Y, Sawamura K, Matsushita M, Imagama S. Gradual Reduction Using Overhead Traction for Late-Detected Developmental Dysplasia of the Hip: A Report of Three Cases Diagnosed Among Children Over Four Years Old. Cureus. 2024. DOI: 10.7759/cureus.63833
  40. Oishi R, Takeda I, Ode Y, Okada Y, Kato D, Nakashima H, Imagama S, Wake H. Neuromodulation with transcranial direct current stimulation contributes to motor function recovery via microglia in spinal cord injury. Sci Rep. 2024. DOI: 10.1038/s41598-024-69127-7
  41. Saeki M, Yoneda H, Yamamoto M. Lateral elbow magnetic resonance imaging findings in patients without pain complaints. JPRAS Open. 2024. DOI: 10.1016/j.jpra.2024.06.005
  42. Miyairi Y, Ohkawara B, Sato A, Sawada R, Ishii H, Tomita H, Inoue T, Nakashima H, Ito M, Masuda A, Hosono Y, Imagama S, Ohno K. A class of chemical compounds enhances clustering of muscle nicotinic acetylcholine receptor in cultured myogenic cells. Biochem Biophys Res Commun. 2024. DOI: 10.1016/j.bbrc.2024.150400
  43. Funahashi H, Osawa Y, Takegami Y, Iida H, Ozawa Y, Ido H, Imagama S. What Are the Sex-Based Differences of Acetabular Coverage Features in Hip Dysplasia? Clin Orthop Relat Res. 2024. DOI: 10.1097/CORR.0000000000003126
  44. Takahashi Y, Takegami Y, Tokutake K, Asami Y, Takahashi H, Kato M, Kanemura T, Imagama S. Analysis of Calcaneal Avulsion Fractures Treated Surgically and Nonsurgically: A Retrospective Multicenter Study. JB JS Open Access. 2024. DOI: 10.2106/JBJS.OA.23.00127
  45. Kaneda T, Takegami Y, Tokutake K, Nakashima H, Mishima K, Mabuchi M, Imagama S. Peri-implant fractures after Intramedullary fixation for femoral trochanteric fracture: a multicenter (TRON Group) study. Eur J Trauma Emerg Surg. 2024. DOI: 10.1007/s00068-024-02567-y
  46. Ouchida J, Nakashima H, Ito S, Segi N, Yamauchi I, Oishi R, Miyairi Y, Morita Y, Ode Y, Nagatani Y, Okada Y, Tsushima M, Kanemura T, Machino M, Ohara T, Ota K, Tachi H, Tsuji T, Kagami Y, Shinjo R, Imagama S. Longitudinal impact of multi-segment spinal fixation surgery on mobility status and clinical outcomes in adult spinal deformity: a multicenter retrospective study. Eur Spine J. 2024. DOI: 10.1007/s00586-024-08397-1
  47. Ozawa Y, Takegami Y, Seki T, Osawa Y, Iida H, Okamoto M, Nakashima H, Ishizuka S, Hasegawa Y, Imagama S. Relationship between locomotive syndrome and advanced glycation end products measured by skin autofluorescence in community-dwelling patients: the Yakumo Study. Nagoya J Med Sci. 2024. DOI: 10.18999/nagjms.86.2.314
  48. Ouchida J, Nakashima H, Kanemura T, Tsushima M, Ito S, Segi N, Tomita H, Morishita K, Oyama H, Oshima K, Imagama S. Analysis of spinopelvic parameters in adult patients with lumbosacral transitional vertebrae. Eur Spine J. 2024. DOI: 10.1007/s00586-024-08378-4
  49. Ouchida J, Nakashima H, Ito S, Segi N, Yamauchi I, Oishi R, Miyairi Y, Morita Y, Ode Y, Nagatani Y, Okada Y, Tsushima M, Machino M, Ota K, Tachi H, Kagami Y, Shinjo R, Ohara T, Tsuji T, Kanemura T, Imagama S. Does global spinal alignment affect the use of walking aids after multi-segment spinal fixation for patients with ASD? A multicenter retrospective study. Eur Spine J. 2024. DOI: 10.1007/s00586-024-08380-w
  50. Sano M, Nishiura Y, Morikawa I, Hoshino A, Uemura JI, Iwatsuki K, Hirata H, Hoshiyama M. Analysis of the alpha activity envelope in electroencephalography in relation to the ratio of excitatory to inhibitory neural activity. PLoS One. 2024. DOI: 10.1371/journal.pone.0305082
  51. Kagami Y, Nakashima H, Segi N, Shinjo R, Imagama S. Reply to \"Letter to the Editor Concerning 'Clinical Outcomes of Condoliase Injection Therapy for Lateral Lumbar Disc Herniation' by Kagami et al.\". Spine Surg Relat Res. 2024. DOI: 10.22603/ssrr.2024-0001
  52. Urakawa H, Imagama S. Vimseltinib for tenosynovial giant cell tumour. Lancet. 2024. DOI: 10.1016/S0140-6736(24)01113-9
  53. Iwase K, Takegami Y, Tokutake K, Oshika Y, Yokoyama H, Tanaka K, Sakai T, Imagama S. Low and high body mass index and lower numbers of screws in the articular segment are risk factors for non-union of distal humeral fractures in the elderly: A multi-center retrospective study (TRON study). Shoulder Elbow. 2024. DOI: 10.1177/17585732221131923
  54. Ogura K, Takegami Y, Kuwahara Y, Tokutake K, Nakashima R, Yamamoto S, Naito K, Kasai T, Makida K, Imagama S. Comparison of conjoined tendon-preserving posterior approach and conventional posterolateral approach in hemiarthroplasty for femoral neck fracture in the elderly: A multicenter (TRON group) retrospective study. J Orthop Sci. 2025. DOI: 10.1016/j.jos.2024.05.003
  55. Ido H, Osawa Y, Takegami Y, Hiroto F, Ozawa Y, Imagama S. Factors related to collapse progression in Japanese Investigation Committee classification type B osteonecrosis of the femoral head. Int Orthop. 2024. DOI: 10.1007/s00264-024-06221-5
  56. Yamauchi I, Nakashima H, Inoue T, Nojima T, Imagama S. Neurologic recovery following laminectomy and tumor resection of a pediatric cervical synovial osteochondromatosis causing paralysis. Eur Spine J. 2024. DOI: 10.1007/s00586-024-08304-8
  57. Iida H, Takegami Y, Sakai Y, Watanabe T, Osawa Y, Imagama S. Early surgery within 48 hours of admission for hip fracture did not improve 1-year mortality in Japan: a single-institution cohort study. Hip Int. 2024. DOI: 10.1177/11207000241248836
  58. Sumi S, Takegami Y, Tokutake K, Nakashima H, Mishima K, Takatsu T, Imagama S. Risk factors of periprosthetic joint infection after hemiarthroplasty for displaced femoral neck fracture in the elderly: Analysis of 1619 cases in the multicenter database. Injury. 2024. DOI: 10.1016/j.injury.2024.111603
  59. Segi N, Nakashima H, Ito S, Ouchida J, Oishi R, Yamauchi I, Miyairi Y, Morita Y, Matsumoto T, Kanbara S, Ito K, Imagama S. Trabecular Bone Remodeling after Posterior Lumbar Interbody Fusion: Comparison of the Osseointegration in Three-Dimensional Porous Titanium Cages and Polyether-Ether-Ketone Cages. Global Spine J. 2025. DOI: 10.1177/21925682241255686
  60. Suzuki M, Asai S, Ohashi Y, Sobue Y, Ishikawa H, Takahashi N, Terabe K, Sato R, Kosugiyama H, Hasegawa J, Ohno Y, Sugiura T, Imagama S. Factors associated with discrepancies in disease activity as assessed by SDAI and RAPID3 in patients with rheumatoid arthritis: Data from a multicentre observational study (T-FLAG). Mod Rheumatol. 2024. DOI: 10.1093/mr/roae040
  61. Noritake H, Takegami Y, Tokutake K, Nakashima H, Mishima K, Ito T, Imagama S. Descriptive analysis of incidence and risk factors for short intramedullary nail breakage in femoral intertrochanteric fractures: a multicenter (TRON group) retrospective study. Eur J Orthop Surg Traumatol. 2024. DOI: 10.1007/s00590-024-03957-z
  62. Tanaka S, Takegami Y, Osawa Y, Okamoto M, Imagama S. Retrospective study comparing the accuracies of handheld infrared stereo camera and augmented reality-based navigation systems for total hip arthroplasty. Arch Orthop Trauma Surg. 2024. DOI: 10.1007/s00402-024-05330-5
  63. Yamauchi I, Nakashima H, Ito S, Segi N, Ouchida J, Oishi R, Miyairi Y, Morita Y, Ode Y, Nagatani Y, Okada Y, Morishita K, Takeichi Y, Kagami Y, Tachi H, Ohshima K, Ogura K, Shinjo R, Ohara T, Tsuji T, Kanemura T, Imagama S. Preoperative low Hounsfield units in the lumbar spine are associated with postoperative mechanical complications in adult spinal deformity. Eur Spine J. 2024. DOI: 10.1007/s00586-024-08261-2
  64. Iida H, Takegami Y, Osawa Y, Funahashi H, Ozawa Y, Ido H, Asamoto T, Otaka K, Tanaka S, Nakashima H, Ishizuka S, Seki T, Hasegawa Y, Imagama S. Association between advanced glycation end-products and fall risk in older adults: The Yakumo Study. Geriatr Gerontol Int. 2024. DOI: 10.1111/ggi.14871
  65. Saeki M, Yoneda H, Yamamoto M. Posterior Translation of the Radial Head in Magnetic Resonance Imaging of Lateral Epicondylitis. Plast Reconstr Surg Glob Open. 2024. DOI: 10.1097/GOX.0000000000005746
  66. Segi N, Nakashima H, Ito S, Ouchida J, Kayamoto A, Oishi R, Yamauchi I, Takegami Y, Ishizuka S, Seki T, Hasegawa Y, Imagama S. Is spinopelvic compensation associated with unstable gait?: Analysis using whole spine X-rays and a two-point accelerometer during gait in healthy adults. Gait Posture. 2024. DOI: 10.1016/j.gaitpost.2024.04.013
  67. Miyairi Y, Nakashima H, Ito S, Segi N, Ouchida J, Oishi R, Yamauchi I, Machino M, Seki T, Ishizuka S, Takegami Y, Hasegawa Y, Imagama S. Obesity Is Associated with Asymptomatic Vertebral Fractures: A Yakumo Study. J Clin Med. 2024. DOI: 10.3390/jcm13072063
  68. Ito S, Nakashima H, Segi N, Ouchida J, Oishi R, Yamauchi I, Ishizuka S, Takegami Y, Seki T, Hasegawa Y, Imagama S. A Longitudinal Study on the Effect of Exercise Habits on Locomotive Syndrome and Quality of Life during the Coronavirus Disease 2019 Pandemic. J Clin Med. 2024. DOI: 10.3390/jcm13051385
  69. Kimura Y, Asami Y, Tokutake K, Takegami Y, Oshima K, Ishihara N, Imagama S. Diaphyseal forearm fracture management in adolescent patients from 2011 to 2020: A multicenter study of surgery and regional anesthesia trends. J Orthop Sci. 2025. DOI: 10.1016/j.jos.2024.03.009
  70. Kawashima I, Ishizuka S, Oba H, Sakaguchi T, Nakashima H, Takegami Y, Imagama S. Prevalence and treatment rates of osteoporosis among individuals with rotator cuff tears. J Shoulder Elbow Surg. 2024. DOI: 10.1016/j.jse.2024.02.026
  71. Murase F, Takegami Y, Tokutake K, Oyama H, Arakawa O, Takatsu T, Nakashima H, Mishima K, Imagama S. Fracture of the patella involving inferior pole is associated with postoperative patella baja - A retrospective multicenter study. J Orthop Sci. 2025. DOI: 10.1016/j.jos.2024.03.008
  72. Funahashi H, Matsushita M, Esaki R, Mishima K, Ohkawara B, Kamiya Y, Takegami Y, Ohno K, Kitoh H, Imagama S. Long-term oral meclozine administration improves survival rate and spinal canal stenosis during postnatal growth in a mouse model of achondroplasia in both sexes. JBMR Plus. 2024. DOI: 10.1093/jbmrpl/ziae018
  73. Sudo Y, Takegami Y, Tokutake K, Shimizu K, Naruse K, Takatsu T, Imagama S. Does Early and Late Weight Bearing Have an Effect on the Results of Elderly Tibial Plateau Fractures with Internal Fixation?: A Multicenter (TRON Group) Study. Indian J Orthop. 2024. DOI: 10.1007/s43465-024-01113-7
  74. Yamauchi I, Nakashima H, Machino M, Ito S, Segi N, Tauchi R, Ohara T, Kawakami N, Imagama S. Rod fracture after multiple-rod technique for adult spinal deformity: a case report. Nagoya J Med Sci. 2024. DOI: 10.18999/nagjms.86.1.135
  75. Asai S, Suzuki M, Hara R, Hirano Y, Nagamine S, Kaneko T, Suto T, Okano T, Yoshioka Y, Hirao M, Wakabayashi H, Fujibayashi T, Watanabe T, Takakubo Y, Ishikawa H, Nasu Y, Takemoto T, Kato T, Torikai E, Koyama K, Takagi H, Fujiwara T, Sobue Y, Ohashi Y, Nishiume T, Terabe K, Kojima M, Kojima T, Imagama S. Comparison of effectiveness of methotrexate in patients with late-onset versus younger-onset rheumatoid arthritis: Real-world data from an inception cohort in Japan (NICER-J). Mod Rheumatol. 2024. DOI: 10.1093/mr/roae027
  76. Asamoto T, Takegami Y, Sato Y, Takahara S, Yamamoto N, Inagaki N, Maki S, Saito M, Imagama S. External validation of a deep learning model for predicting bone mineral density on chest radiographs. Arch Osteoporos. 2024. DOI: 10.1007/s11657-024-01372-9
  77. Iida H, Takegami Y, Osawa Y, Funahashi H, Ozawa Y, Ido H, Asamoto T, Otaka K, Tanaka S, Imagama S. Association of mid-thigh quadriceps muscle quality with postoperative outcomes in patients with hip osteoarthritis undergoing total hip arthroplasty: a retrospective cohort study. Int Orthop. 2024. DOI: 10.1007/s00264-024-06142-3
  78. Sawamura K, Kitoh H, Matsushita M, Mishima K, Kamiya Y, Imagama S. Quality of life in adult patients with developmental dysplasia of the hip who were treated for hip dislocation during childhood. J Pediatr Orthop B. 2025. DOI: 10.1097/BPB.0000000000001173
  79. Takahashi H, Takegami Y, Tokutake K, Takahashi Y, Kato M, Mabuchi M, Imagama S. Does Preoperative Manual Reduction (Omoto Technique) Affect Surgical Outcomes for Calcaneal Fractures? A Multicenter (TRON Group) Retrospective Study. J Foot Ankle Surg. 2024. DOI: 10.1053/j.jfas.2024.02.003
  80. Ito S, Sakai Y, Harada A, Ando K, Kobayashi K, Nakashima H, Machino M, Kambara S, Inoue T, Hida T, Ito K, Ishiguro N, Imagama S. Response to the Letter to the Editor: Evaluation of the Association between Neck Pain and the Trapezius Muscles in Patients with Cervical Myelopathy Using Motor Evoked Potential: A Retrospective Study. Asian Spine J. 2024. DOI: 10.31616/asj.2022.0028.r2
  81. Yoneda H, Takeda S, Saeki M, Iwatsuki K, Yamamoto M, Tatebe M, Hirata H. Utility of severity scoring systems for mangled upper limb salvage: A systematic review and meta-analysis. Injury. 2024. DOI: 10.1016/j.injury.2024.111447
  82. Otaka K, Osawa Y, Takegami Y, Iida H, Ozawa Y, Funahashi H, Imagama S. Computer simulation study of cementless cup placement for dysplastic hip osteoarthritis using subluxation percentage of Crowe classification. J Orthop Res. 2024. DOI: 10.1002/jor.25819
  83. Tsugeno H, Takegami Y, Tokutake K, Mishima K, Nakashima H, Kobayashi K, Imagama S. Comparing short vs. intermediate and long nails in elderly patients with unstable multifragmental femoral trochanteric fractures (AO type A2): Multicenter (TRON group) retrospective study. Injury. 2024. DOI: 10.1016/j.injury.2024.111420
  84. Segi N, Nakashima H, Ito S, Ouchida J, Oishi R, Yamauchi I, Miyairi Y, Morita Y, Takegami Y, Ishizuka S, Seki T, Hasegawa Y, Imagama S. Do Postural and Walking Stabilities Change over a Decade by Aging? A Longitudinal Study. J Clin Med. 2024. DOI: 10.3390/jcm13041081
  85. Okamoto M, Nakashima H, Sakai K, Takegami Y, Osawa Y, Watanabe J, Ito S, Hibi H, Imagama S. Cellular senescence is associated with osteonecrosis of the femoral head while mesenchymal stem cell conditioned medium inhibits bone collapse. Sci Rep. 2024. DOI: 10.1038/s41598-024-53400-w
  86. Ozawa Y, Takegami Y, Osawa Y, Asamoto T, Tanaka S, Imagama S. Anti-sclerostin antibody therapy prevents post-ischemic osteonecrosis bone collapse via interleukin-6 association. Bone. 2024. DOI: 10.1016/j.bone.2024.117030
  87. Ido H, Takegami Y, Osawa Y, Okamoto M, Iida H, Imagama S. Risk factors for intraoperative femoral fractures in cementless bipolar hip arthroplasty for femoral neck fracture in multicenter: The TRON group study. J Orthop Sci. 2025. DOI: 10.1016/j.jos.2024.01.005
  88. Sugiura H, Tatebe M, Yoneda H, Nishizuka T, Morita A, Yamamoto M. A Small Ratio of Proximal to Distal Bone Fragments Is a Risk Factor for Scaphoid Nonunion: A Volumetric Analysis of Preoperative CT. J Wrist Surg. 2025. DOI: 10.1055/s-0044-1779286
  89. Suzuki M, Kojima T, Terabe K, Ohashi Y, Sato R, Kosugiyama H, Hasegawa J, Ohno Y, Nagai K, Ohnishi C, Sugiura H, Fujita H, Nagayoshi M, Kojima M, Asai S, Imagama S. Association between laughter, frailty, and depression in rheumatoid arthritis patients. Int J Rheum Dis. 2024. DOI: 10.1111/1756-185X.15034
  90. Saeki M, Yoneda H, Yamamoto M. Clinical and radiographic results of lunate resection and vascularized os pisiform transfer for Kienböck's disease. JPRAS Open. 2024. DOI: 10.1016/j.jpra.2023.12.010
  91. Tanaka H, Kurimoto S, Hirata H. Efficacy of collagen conduit wrapping with collagen fibers on nerve regeneration in sciatic nerve injury with partial transection: An experimental study in the rat model. J Biomed Mater Res B Appl Biomater. 2024. DOI: 10.1002/jbm.b.35369
  92. Miyamoto K, Kurokouchi K, Ishizuka S, Takahashi S, Tsukahara T, Kawai R, Sakai T, Oba H, Sakaguchi T, Imagama S. Double-bundle anterior cruciate ligament reconstruction in patients aged 60 years and older. Asia Pac J Sports Med Arthrosc Rehabil Technol. 2024. DOI: 10.1016/j.asmart.2023.11.003
  93. Ohkawara B, Tomita H, Inoue T, Zhang S, Kanbara S, Koshimizu H, Miyasaka Y, Takeda JI, Nishiwaki H, Nakashima H, Ito M, Masuda A, Ishiguro N, Ogi T, Ohno T, Imagama S, Ohno K. Calcitriol ameliorates motor deficits and prolongs survival of Chrne-deficient mouse, a model for congenital myasthenic syndrome, by inducing Rspo2. Neurotherapeutics. 2024. DOI: 10.1016/j.neurot.2024.e00318
  94. Koshimizu H, Nakashima H, Ohara T, Tauchi R, Kanemura T, Shinjo R, Machino M, Ito S, Ando K, Imagama S. Reply to \"Letter to the Editor Concerning 'Implant-Related Complications After Spinal Fusion: A Multicenter Study.' by Koshimizu et al.\". Global Spine J. 2024. DOI: 10.1177/21925682241227412
  95. Segi N, Nakashima H, Ito S, Yokogawa N, Sasagawa T, Watanabe K, Nori S, Funayama T, Eto F, Nakajima H, Terashima Y, Hirota R, Hashimoto K, Onoda Y, Furuya T, Yunde A, Ikegami S, Uehara M, Suzuki H, Imajo Y, Uei H, Sawada H, Kawaguchi K, Nakanishi K, Suzuki N, Oshima Y, Hasegawa T, Iizuka Y, Tonomura H, Terai H, Akeda K, Seki S, Ishihara M, Inoue G, Funao H, Yoshii T, Kaito T, Kiyasu K, Tominaga H, Kakutani K, Sakai D, Ohba T, Otsuki B, Miyazaki M, Murotani K, Okada S, Imagama S, Kato S. Early Versus Delayed Surgery for Elderly Traumatic Cervical Spinal Injury: A Nationwide Multicenter Study in Japan. Global Spine J. 2025. DOI: 10.1177/21925682241227430
  96. Hasegawa K, Takegami Y, Tokutake K, Nakashima H, Mishima K, Kobayashi K, Imagama S. Early versus delayed weight bearing after internal fixation for femoral neck fracture in younger adults: A multicenter retrospective study. Injury. 2024. DOI: 10.1016/j.injury.2023.111292
  97. Iwata M, Takegami Y, Tokutake K, Kurokawa H, Takami H, Terasawa S, Takatsu T, Imagama S. Predictive factors for reoperation after periprosthetic femoral fracture: A retrospective multicenter (TRON) study. J Orthop Sci. 2024. DOI: 10.1016/j.jos.2023.11.016
  98. Ohashi Y, Takahashi N, Sobue Y, Suzuki M, Sato R, Maeda M, Kihira D, Kishimoto K, Terabe K, Asai S, Imagama S. Associations of frailty with RA-ILD and poor control of disease activity in patients with rheumatoid arthritis: A multi-center retrospective observational study. J Orthop Sci. 2024. DOI: 10.1016/j.jos.2023.11.012
  99. Ohashi Y, Takahashi N, Sobue Y, Suzuki M, Sato R, Maeda M, Terabe K, Asai S, Imagama S. Well-controlled disease activity with drug treatment will not improve the frailty status of RA patients to robust state: A multicenter observational study (T-FLAG). Int J Rheum Dis. 2024. DOI: 10.1111/1756-185X.14946
  100. Asamoto T, Osawa Y, Takegami Y, Takemoto G, Komatsu D, Seki T, Imagama S. The survey of bone allograft transplantation in a Japanese regional bone bank. J Orthop Sci. 2024. DOI: 10.1016/j.jos.2023.11.001
  101. Funahashi H, Takegami Y, Osawa Y, Nakashima H, Ishizuka S, Fujii R, Yamada H, Suzuki K, Hasegawa Y, Imagama S. Circulating miRNA-122 is associated with knee osteoarthritis progression: A 6-year longitudinal cohort study in the Yakumo study. J Orthop Sci. 2024. DOI: 10.1016/j.jos.2023.10.004
  102. Sobue Y, Suzuki M, Ohashi Y, Koshima H, Okui N, Funahashi K, Ishikawa H, Inoue H, Asai S, Terabe K, Maeda M, Sato R, Kosugiyama H, Ohno Y, Imagama S. Relationship between locomotive syndrome and large joint symptoms in rheumatoid arthritis patients. Int J Rheum Dis. 2024. DOI: 10.1111/1756-185X.14947
  103. Ohshima K, Nakashima H, Segi N, Ito S, Ouchida J, Takegami Y, Ishizuka S, Hasegawa Y, Imagama S. The prevalence and characteristics of diffuse idiopathic skeletal hyperostosis in the community-living middle-aged and elderly population: The Yakumo study. J Orthop Sci. 2024. DOI: 10.1016/j.jos.2023.10.005
  104. Kato M, Takegami Y, Tokutake K, Asami Y, Takahashi Y, Takahashi H, Kumagai H, Imagama S. Comparison of the Outcomes of Plating, Screw Fixation, and Pinning in Sanders Type II Fractures: A Multicenter (TRON) Retrospective Study. J Foot Ankle Surg. 2024. DOI: 10.1053/j.jfas.2023.10.002
  105. Asamoto T, Osawa Y, Takegami Y, Okamoto M, Iida H, Imagama S. Fall risk in patient with dysplastic hip osteoarthritis. Int Orthop. 2024. DOI: 10.1007/s00264-023-05938-z
  106. Osawa Y, Seki T, Takegami Y, Okamoto M, Iida H, Imagama S. Extension of the Antero-Posterior Necrotic Regions Associated With Collapse Cessation in Osteonecrosis of the Femoral Head. J Arthroplasty. 2024. DOI: 10.1016/j.arth.2023.08.020
  107. Ishihara N, Tokutake K, Takegami Y, Asami Y, Kumagai H, Ota H, Kimura Y, Ohshima K, Imagama S. An age-matched comparative study on intramedullary nailing and plate fixation of both-bone diaphyseal forearm fracture in adolescents. Eur J Orthop Surg Traumatol. 2024. DOI: 10.1007/s00590-023-03679-8
  108. Kishimoto K, Asai S, Suzuki M, Kihira D, Sato R, Terabe K, Ohashi Y, Maeda M, Imagama S. Intervertebral fusion sites in patients with ankylosing spondylitis: A computed tomography study. Mod Rheumatol. 2024. DOI: 10.1093/mr/road065
  109. Ido H, Osawa Y, Takegami Y, Kishimoto K, Kihira D, Suzuki M, Asai S, Imagama S. Sacroiliac joint fusion in patients with ankylosing spondylitis is associated with hip involvement. J Orthop Sci. 2024. DOI: 10.1016/j.jos.2023.06.012
  110. Sakaguchi T, Mishima S, Ishizuka S, Oba H, Mizuno T, Kawashima I, Fukui J, Fujii S, Imagama S. Unusual cave-like subacromial bone erosion caused by suture-knots for rotator cuff repair with pathological findings of foreign-body granuloma from polyethylene particle. JSES Rev Rep Tech. 2024. DOI: 10.1016/j.xrrt.2023.06.001
  111. Okamoto M, Takegami Y, Osawa Y, Iida H, Funahashi H, Seki T, Imagama S. Risk factors for lateralization or superiorization of the center of the femoral head in eccentric rotational acetabular osteotomy. J Orthop Sci. 2024. DOI: 10.1016/j.jos.2023.06.010
  112. Segi N, Nakashima H, Ito S, Yokogawa N, Ikegami S, Watanabe K, Funayama T, Hasegawa T, Tonomura H, Kakutani K, Furuya T, Suzuki N, Kiyasu K, Tominaga H, Miyazaki M, Terashima Y, Suzuki H, Hashimoto K, Uei H, Funao H, Kaito T, Kawaguchi K, Sakai D, Seki S, Otsuki B, Inoue G, Okada S, Imagama S, Kato S. Worsening ambulation in elderly patients with cervical odontoid fractures: A nationwide multicenter study in Japan. J Orthop Sci. 2024. DOI: 10.1016/j.jos.2023.05.006
  113. Takeda S, Kurimoto S, Tanaka Y, Mitsuya S, Hirata H, Murakami H, Jianmongkol S, Okamoto H. Mid-term outcomes of digital nerve injuries treated with Renerve® synthetic collagen nerve conduits: A retrospective single-center study. J Orthop Sci. 2024. DOI: 10.1016/j.jos.2023.04.004
  114. Suzuki M, Asai S, Hara R, Hirano Y, Nagamine S, Kaneko T, Sakane H, Okano T, Yoshioka Y, Tsuji S, Wakabayashi H, Takakubo Y, Takemoto T, Fujibayashi T, Watanabe T, Kato T, Ishikawa H, Nasu Y, Torikai E, Kaneko A, Takagi H, Fujiwara T, Kihira D, Hattori K, Kishimoto K, Ohashi Y, Sobue Y, Yokota Y, Nishiume T, Terabe K, Takahashi N, Kojima M, Imagama S, Kojima T. Choice of and response to treatment in patients with early-diagnosed rheumatoid arthritis: Real-world data from an inception cohort in Japan (NICER-J). J Orthop Sci. 2024. DOI: 10.1016/j.jos.2023.03.020
  115. Sugino T, Takegami Y, Bando K, Sato T, Fujita T, Oka Y, Imagama S. The Wait Time for Surgery Following Injury Affects Functional Outcomes and Complications After an Ankle Fracture: A Propensity Score-Matched Multicenter Study, the TRON Study. Foot Ankle Spec. 2024. DOI: 10.1177/19386400231164211
  116. Segi N, Nakashima H, Shinjo R, Kagami Y, Machino M, Ito S, Ouchida J, Morishita K, Oishi R, Yamauchi I, Imagama S. Trabecular Bone Remodeling After Posterior Lumbar Interbody Fusion: Comparison of Three-Dimensional Porous Tantalum and Titanium-Coated Polyetheretherketone Interbody Cages. Global Spine J. 2024. DOI: 10.1177/21925682231170613
  117. Kagami Y, Nakashima H, Ito K, Satake K, Tsushima M, Ouchida J, Morita Y, Ode Y, Segi N, Imagama S, Kanemura T. The anatomical relationship between the celiac artery and the median arch ligament in degenerative spinal surgery. J Orthop Sci. 2024. DOI: 10.1016/j.jos.2023.02.015
  118. Segi N, Nakashima H, Shinjo R, Kagami Y, Machino M, Ito S, Ouchida J, Imagama S. Reply to \"Letter to the Editor Concerning 'Trabecular Bone Remodeling as a New Indicator of Osteointegration After Posterior Lumbar Interbody Fusion.' by Segi et al.\". Global Spine J. 2024. DOI: 10.1177/21925682231162860
  119. Ito K, Nakashima H, Kagami Y, Ouchida J, Satake K, Tsushima M, Tomita H, Ode Y, Nagatani Y, Imagama S, Kanemura T. An appropriate method for predicting the femoral angle on whole-body X-ray images from full-spine X-ray images. J Orthop Sci. 2024. DOI: 10.1016/j.jos.2023.02.007
  120. Takemoto G, Osawa Y, Seki T, Takegami Y, Kato D, Okamoto M, Iida H, Imagama S. A large preoperative pelvic oblique angle affects perception of leg length discrepancy after total hip arthroplasty. J Orthop Sci. 2024. DOI: 10.1016/j.jos.2023.01.013
  121. Yamamoto S, Takegami Y, Tokutake K, Nakashima R, Naito K, Ogura K, Kato D, Imagama S. Effect of anaesthesia on cemented hemiarthroplasty -A multicentre retrospective study (TRON study). J Orthop Sci. 2024. DOI: 10.1016/j.jos.2023.02.005
  122. Kurokawa H, Takegami Y, Tokutake K, Takami H, Iwata M, Terasawa S, Inoue H, Imagama S. Predictive factors for one-year mortality after surgery for periprosthetic femoral fracture: A retrospective multicenter (TRON group) study. J Orthop Sci. 2024. DOI: 10.1016/j.jos.2022.12.015
  123. Segi N, Nakashima H, Machino M, Ito S, Yokogawa N, Sasagawa T, Funayama T, Eto F, Watanabe K, Nori S, Furuya T, Yunde A, Nakajima H, Hasegawa T, Yamada T, Terashima Y, Hirota R, Suzuki H, Imajo Y, Ikegami S, Uehara M, Tonomura H, Sakata M, Hashimoto K, Onoda Y, Kawaguchi K, Haruta Y, Suzuki N, Kato K, Uei H, Sawada H, Nakanishi K, Misaki K, Terai H, Tamai K, Inoue G, Shirasawa E, Kakutani K, Iizuka Y, Takasawa E, Akeda K, Kiyasu K, Tominaga H, Tokumoto H, Funao H, Oshima Y, Yoshii T, Kaito T, Sakai D, Ohba T, Seki S, Otsuki B, Ishihara M, Miyazaki M, Okada S, Imagama S, Kato S. Epidemiology of Cervical Fracture/Cervical Spinal Cord Injury and Changes in Surgical Treatment Modalities in Elderly Individuals During a 10-year Period: A Nationwide Multicenter Study in Japan. Global Spine J. 2024. DOI: 10.1177/21925682231151643
  124. Shimizu K, Takegami Y, Tokutake K, Naruse K, Sudo Y, Matsubara Y, Imagama S. What factors are associated with loss of alignment after open reduction and internal fixation for tibial plateau fractures? A retrospective multicenter (TRON group) study. J Orthop Sci. 2024. DOI: 10.1016/j.jos.2022.12.008
  125. Iida H, Seki T, Takegami Y, Osawa Y, Kato D, Takemoto G, Ando K, Ishizuka S, Hasegawa Y, Imagama S. Association between locomotive syndrome and fall risk in the elderly individuals in Japan: The Yakumo study. J Orthop Sci. 2024. DOI: 10.1016/j.jos.2022.11.023
  126. Ohashi Y, Takahashi N, Sobue Y, Suzuki M, Hattori K, Kishimoto K, Terabe K, Asai S, Kojima T, Kojima M, Imagama S. Disease activity at baseline is an independent predictor of frailty at one year in pre-frail patients with rheumatoid arthritis; a multicenter retrospective observational study. J Orthop Sci. 2024. DOI: 10.1016/j.jos.2022.10.025
  127. Komaki K, Takegami Y, Tokutake K, Hanabayashi M, Kuwahara Y, Yamada Y, Imagama S. Early weight bearing versus late weight bearing after intramedullary nailing for distal femoral fracture (AO/OTA 33) in elderly patients: A multicenter propensity-matched study. J Orthop Sci. 2024. DOI: 10.1016/j.jos.2022.10.023
  128. Koshimizu H, Nakashima H, Tomita H, Segi N, Ito S, Machino M, Ando K, Imagama S. Pedicular kinking during posterior corrective procedure for thoracolumbar kyphoscoliosis with unstable osteoporotic fracture. J Orthop Sci. 2024. DOI: 10.1016/j.jos.2022.06.007
  129. Otaka K, Osawa Y, Seki T, Inoue H, Imagama S. Total hip arthroplasty and autologous bone grafting for treating bilateral osteonecrosis of the acetabulum: A case report. J Orthop Sci. 2024. DOI: 10.1016/j.jos.2022.04.004
  130. Segi N, Nakashima H, Shinjo R, Kagami Y, Ando K, Machino M, Ito S, Koshimizu H, Tomita H, Ouchida J, Imagama S. Trabecular Bone Remodeling as a New Indicator of Osteointegration After Posterior Lumbar Interbody Fusion. Global Spine J. 2024. DOI: 10.1177/21925682221090484
  131. Koshimizu H, Nakashima H, Ohara T, Tauchi R, Kanemura T, Shinjo R, Machino M, Ito S, Ando K, Imagama S. Implant-Related Complications after Spinal Fusion: A Multicenter Study. Global Spine J. 2024. DOI: 10.1177/21925682221094267

• 2023

  1. Hasegawa K, Takegami Y, Tokutake K, Nakashima H, Mishima K, Kobayashi K, Imagama S. Early versus delayed weight bearing after internal fixation for femoral neck fracture in younger adults: A multicenter retrospective study. Injury. 2024. DOI: 10.1016/j.injury.2023.111292
  2. Yamamoto M, Kato Y, Takeuchi J. Hand function and quality of life in patients with diabetes mellitus before and during the COVID-19 pandemic. Nagoya J Med Sci. 2023. DOI: 10.18999/nagjms.85.4.659
  3. Iwata M, Takegami Y, Tokutake K, Kurokawa H, Takami H, Terasawa S, Takatsu T, Imagama S. Predictive factors for reoperation after periprosthetic femoral fracture: A retrospective multicenter (TRON) study. J Orthop Sci. 2024. DOI: 10.1016/j.jos.2023.11.016
  4. Ouchida J, Nakashima H, Kanemura T, Ito K, Tsushima M, Machino M, Ito S, Segi N, Nagatani Y, Kagami Y, Imagama S. Impact of Obesity, Osteopenia, and Scoliosis on Interobserver Reliability of Measures of the Spinopelvic Sagittal Radiographic Parameters. Spine Surg Relat Res. 2023. DOI: 10.22603/ssrr.2023-0050
  5. Yamauchi I, Nakashima H, Ito S, Segi N, Ouchida J, Tauchi R, Ohara T, Kawakami N, Imagama S. Wedge-Shaped Deformity of the First Sacral Vertebra Associated with Adolescent Idiopathic Scoliosis: A Comparison of Cases with and without Scoliosis. Spine Surg Relat Res. 2023. DOI: 10.22603/ssrr.2023-0134
  6. Ito S, Nakashima H, Segi N, Ouchida J, Oda M, Yamauchi I, Oishi R, Miyairi Y, Mori K, Imagama S. Automated Detection of the Thoracic Ossification of the Posterior Longitudinal Ligament Using Deep Learning and Plain Radiographs. Biomed Res Int. 2023. DOI: 10.1155/2023/8495937
  7. Mizuno T, Matsui Y, Tomida M, Suzuki Y, Ishizuka S, Watanabe T, Takemura M, Nishita Y, Tange C, Shimokata H, Imagama S, Otsuka R, Arai H. Relationship between quadriceps muscle computed tomography measurement and motor function, muscle mass, and sarcopenia diagnosis. Front Endocrinol (Lausanne). 2023. DOI: 10.3389/fendo.2023.1259350
  8. Ohashi Y, Takahashi N, Sobue Y, Suzuki M, Sato R, Maeda M, Kihira D, Kishimoto K, Terabe K, Asai S, Imagama S. Associations of frailty with RA-ILD and poor control of disease activity in patients with rheumatoid arthritis: A multi-center retrospective observational study. J Orthop Sci. 2024. DOI: 10.1016/j.jos.2023.11.012
  9. Kuwahara Y, Takegami Y, Mitsuya S, Tokutake K, Yamauchi K, Imagama S. Locked Tension Band Wiring: A Modified Technique for Olecranon Fractures-A Multicenter Study Comparing Clinical Outcomes and Complications with Conventional Methods. Indian J Orthop. 2023. DOI: 10.1007/s43465-023-01017-y
  10. Ohashi Y, Takahashi N, Sobue Y, Suzuki M, Sato R, Maeda M, Terabe K, Asai S, Imagama S. Well-controlled disease activity with drug treatment will not improve the frailty status of RA patients to robust state: A multicenter observational study (T-FLAG). Int J Rheum Dis. 2024. DOI: 10.1111/1756-185X.14946
  11. Asamoto T, Osawa Y, Takegami Y, Takemoto G, Komatsu D, Seki T, Imagama S. The survey of bone allograft transplantation in a Japanese regional bone bank. J Orthop Sci. 2024. DOI: 10.1016/j.jos.2023.11.001
  12. Funahashi H, Takegami Y, Osawa Y, Nakashima H, Ishizuka S, Fujii R, Yamada H, Suzuki K, Hasegawa Y, Imagama S. Circulating miRNA-122 is associated with knee osteoarthritis progression: A 6-year longitudinal cohort study in the Yakumo study. J Orthop Sci. 2024. DOI: 10.1016/j.jos.2023.10.004
  13. Miyamoto K, Kurokouchi K, Ishizuka S, Takahashi S, Idota M, Haga T, Imagama S. Arthroscopic All-Suture Anchor Technique for Unstable Ramp Lesions with Medial Meniscal Defects. Arthrosc Tech. 2023. DOI: 10.1016/j.eats.2023.06.015
  14. Sobue Y, Suzuki M, Ohashi Y, Koshima H, Okui N, Funahashi K, Ishikawa H, Inoue H, Asai S, Terabe K, Maeda M, Sato R, Kosugiyama H, Ohno Y, Imagama S. Relationship between locomotive syndrome and large joint symptoms in rheumatoid arthritis patients. Int J Rheum Dis. 2024. DOI: 10.1111/1756-185X.14947
  15. Ohshima K, Nakashima H, Segi N, Ito S, Ouchida J, Takegami Y, Ishizuka S, Hasegawa Y, Imagama S. The prevalence and characteristics of diffuse idiopathic skeletal hyperostosis in the community-living middle-aged and elderly population: The Yakumo study. J Orthop Sci. 2024. DOI: 10.1016/j.jos.2023.10.005
  16. Kato M, Takegami Y, Tokutake K, Asami Y, Takahashi Y, Takahashi H, Kumagai H, Imagama S. Comparison of the Outcomes of Plating, Screw Fixation, and Pinning in Sanders Type II Fractures: A Multicenter (TRON) Retrospective Study. J Foot Ankle Surg. 2024. DOI: 10.1053/j.jfas.2023.10.002
  17. Takeda S, Yamamoto M, Tanaka Y, Mitsuya S, Yamauchi KI, Hirata H. A nerve-to-implant distance as a novel predictor for lateral femoral cutaneous nerve injuries after anterior subcutaneous pelvic internal fixation. Nagoya J Med Sci. 2023. DOI: 10.18999/nagjms.85.3.569
  18. Takegami Y, Osawa Y, Iida H, Okamoto M, Ozawa Y, Funahashi H, Ido H, Asamoto T, Imagama S. Addressing osteoporosis treatment after hemiarthroplasty for a femoral neck fracture: impact on survival rates after a subsequent periprosthetic femoral fracture - a multicenter (TRON group) retrospective study. Arch Osteoporos. 2023. DOI: 10.1007/s11657-023-01330-x
  19. Oyama S, Niimi N, Mori M, Hirata H. Intra-Articular Ultrasonography Probe for Minimally Invasive Upper Extremity Arthroscopic Surgery: A Phantom Study. J Clin Med. 2023. DOI: 10.3390/jcm12175727
  20. Ito S, Nakashima H, Segi N, Ouchida J, Ishizuka S, Takegami Y, Yoshida T, Hasegawa Y, Imagama S. Association between Locomotive Syndrome and Hearing Loss in Community-Dwelling Adults. J Clin Med. 2023. DOI: 10.3390/jcm12175626
  21. Shimamoto Y, Tokutake K, Takegami Y, Asami Y, Sato K, Ueno H, Nakano T, Fujii S, Okui N, Imagama S. Comparative Outcomes of Anterior and Posterior Plating for Distal-Third Humerus Shaft Fractures. J Hand Surg Am. 2025. DOI: 10.1016/j.jhsa.2023.07.014
  22. Yamashita S, Ishizuka S, Sakai T, Oba H, Sakaguchi T, Mizuno T, Kawashima I, Tsukahara T, Takahashi S, Kurokouchi K, Imagama S. Potential of patellar height measurement methods in predicting recurrent patellar dislocation incidence: a case-control study. BMC Musculoskelet Disord. 2023. DOI: 10.1186/s12891-023-06813-z
  23. Otaka K, Osawa Y, Takegami Y, Seki T, Imagama S. Intertrochanteric curved varus osteotomy for subchondral fracture of the femoral head: a case series. Arthroplasty. 2023. DOI: 10.1186/s42836-023-00202-6
  24. Kagami Y, Nakashima H, Segi N, Shinjo R, Imagama S. Clinical Outcomes of Condoliase Injection Therapy for Lateral Lumbar Disc Herniation. Spine Surg Relat Res. 2023. DOI: 10.22603/ssrr.2022-0189
  25. Asamoto T, Osawa Y, Takegami Y, Okamoto M, Iida H, Imagama S. Fall risk in patient with dysplastic hip osteoarthritis. Int Orthop. 2024. DOI: 10.1007/s00264-023-05938-z
  26. Osawa Y, Seki T, Takegami Y, Okamoto M, Iida H, Imagama S. Extension of the Antero-Posterior Necrotic Regions Associated With Collapse Cessation in Osteonecrosis of the Femoral Head. J Arthroplasty. 2024. DOI: 10.1016/j.arth.2023.08.020
  27. Ishihara N, Tokutake K, Takegami Y, Asami Y, Kumagai H, Ota H, Kimura Y, Ohshima K, Imagama S. An age-matched comparative study on intramedullary nailing and plate fixation of both-bone diaphyseal forearm fracture in adolescents. Eur J Orthop Surg Traumatol. 2024. DOI: 10.1007/s00590-023-03679-8
  28. Zhang J, Nishida Y, Koike H, Zhuo L, Ito K, Ikuta K, Sakai T, Imagama S. Development of Therapeutic Agent for Osteoarthritis via Inhibition of KIAA1199 Activity: Effect of Ipriflavone In Vivo. Int J Mol Sci. 2023. DOI: 10.3390/ijms241512422
  29. Ito S, Nakashima H, Segi N, Ouchida J, Oda M, Yamauchi I, Oishi R, Miyairi Y, Mori K, Imagama S. Automated Detection and Diagnosis of Spinal Schwannomas and Meningiomas Using Deep Learning and Magnetic Resonance Imaging. J Clin Med. 2023. DOI: 10.3390/jcm12155075
  30. Ouchida J, Nakashima H, Kanemura T, Ito K, Tsushima M, Machino M, Ito S, Segi N, Ode Y, Imagama S. Differences in Involvement of Whole-Body Compensatory Alignment for Decompensated Spinopelvic Sagittal Balance. J Clin Med. 2023. DOI: 10.3390/jcm12144690
  31. Ido H, Osawa Y, Takegami Y, Kishimoto K, Kihira D, Suzuki M, Asai S, Imagama S. Sacroiliac joint fusion in patients with ankylosing spondylitis is associated with hip involvement. J Orthop Sci. 2024. DOI: 10.1016/j.jos.2023.06.012
  32. Sakaguchi T, Mishima S, Ishizuka S, Oba H, Mizuno T, Kawashima I, Fukui J, Fujii S, Imagama S. Unusual cave-like subacromial bone erosion caused by suture-knots for rotator cuff repair with pathological findings of foreign-body granuloma from polyethylene particle. JSES Rev Rep Tech. 2024. DOI: 10.1016/j.xrrt.2023.06.001
  33. Ikuta K, Nishida Y, Imagama S, Tanaka K, Ozaki T. The current management of clear cell sarcoma. Jpn J Clin Oncol. 2023. DOI: 10.1093/jjco/hyad083
  34. Matsushita M, Kitoh H, Mishima K, Kamiya Y, Kato D, Takemoto G, Sawamura K, Ueno S, Yasuhiro N, Nishida K, Imagama S. Phase 1b study on the repurposing of meclizine hydrochloride for children with achondroplasia. PLoS One. 2023. DOI: 10.1371/journal.pone.0283425
  35. Okamoto M, Takegami Y, Osawa Y, Iida H, Funahashi H, Seki T, Imagama S. Risk factors for lateralization or superiorization of the center of the femoral head in eccentric rotational acetabular osteotomy. J Orthop Sci. 2024. DOI: 10.1016/j.jos.2023.06.010
  36. Segi N, Nakashima H, Machino M, Ito S, Yokogawa N, Sasagawa T, Funayama T, Eto F, Yamaji A, Watanabe K, Nori S, Takeda K, Furuya T, Yunde A, Nakajima H, Yamada T, Hasegawa T, Terashima Y, Hirota R, Suzuki H, Imajo Y, Ikegami S, Uehara M, Tonomura H, Sakata M, Hashimoto K, Onoda Y, Kawaguchi K, Haruta Y, Suzuki N, Kato K, Uei H, Sawada H, Nakanishi K, Misaki K, Terai H, Tamai K, Shirasawa E, Inoue G, Kakutani K, Kakiuchi Y, Iizuka Y, Takasawa E, Akeda K, Takegami N, Kiyasu K, Tominaga H, Tokumoto H, Funao H, Oshima Y, Yoshii T, Kaito T, Sakai D, Ohba T, Seki S, Otsuki B, Ishihara M, Miyazaki M, Okada S, Imagama S, Kato S. Prognosis of Cervical Diffuse Idiopathic Skeletal Hyperostosis-Related Spine Injuries in Elderly Patients: Analyses of Both Fracture and Spinal Cord Injury Without Fracture. Global Spine J. 2025. DOI: 10.1177/21925682231186757
  37. Ouchida J, Nakashima H, Kanemura T, Okamoto M, Hatsushikano S, Imagama S, Le Huec JC, Hasegawa K. Racial differences in whole-body sagittal alignment between Asians and Caucasians based on international multicenter data. Eur Spine J. 2023. DOI: 10.1007/s00586-023-07829-8
  38. Naruse K, Takegami Y, Tokutake K, Shimizu K, Sudo Y, Shinohara T, Imagama S. What is the Radiographic Factor Associated with Meniscus Injury in Tibial Plateau Factures? Multicenter Retrospective (TRON) Study. Indian J Orthop. 2023. DOI: 10.1007/s43465-023-00888-5
  39. Oyama H, Takegami Y, Tokutake K, Murase F, Arakawa O, Oguchi T, Imagama S. Predictors of postoperative complications of tension band wiring techniques for patella fracture: A retrospective multicenter (TRON group) study. Injury. 2023. DOI: 10.1016/j.injury.2023.110896
  40. Takahashi H, Takegami Y, Tokutake K, Katayama Y, Imagama S. ＜Editors' Choice＞ Hook plate fixation versus locking plate fixation for distal clavicle fracture: a multicenter propensity score-matched study. Nagoya J Med Sci. 2023. DOI: 10.18999/nagjms.85.2.223
  41. Kobayashi K, Sato K, Ando T, Imagama S. Changes in medical costs for adolescent idiopathic scoliosis over the past 15 years. Nagoya J Med Sci. 2023. DOI: 10.18999/nagjms.85.2.333
  42. Kawashima I, Iwahori Y, Ishizuka S, Oba H, Sakaguchi T, Watanabe A, Inoue M, Imagama S. Arthroscopic Bankart repair with peeling osteotomy of the anterior glenoid rim preserves glenoid morphology. J Shoulder Elbow Surg. 2023. DOI: 10.1016/j.jse.2023.05.011
  43. Sato K, Takegami Y, Tokutake K, Shimamoto Y, Ueno H, Ando T, Imagama S. Retrospective multicenter (TRON group) study of humeral shaft fragility fractures: Analysis of mortality rates and risk factors. Injury. 2023. DOI: 10.1016/j.injury.2023.110855
  44. Mishima K, Kamiya Y, Matsushita M, Imagama S. Prognostic value of bone resorption pattern in the anterior portion of the femoral head in Legg-Calvé-Perthes disease. J Child Orthop. 2023. DOI: 10.1177/18632521231164985
  45. Segi N, Nakashima H, Ito S, Yokogawa N, Ikegami S, Watanabe K, Funayama T, Hasegawa T, Tonomura H, Kakutani K, Furuya T, Suzuki N, Kiyasu K, Tominaga H, Miyazaki M, Terashima Y, Suzuki H, Hashimoto K, Uei H, Funao H, Kaito T, Kawaguchi K, Sakai D, Seki S, Otsuki B, Inoue G, Okada S, Imagama S, Kato S. Worsening ambulation in elderly patients with cervical odontoid fractures: A nationwide multicenter study in Japan. J Orthop Sci. 2024. DOI: 10.1016/j.jos.2023.05.006
  46. Sobue Y, Suzuki M, Ohashi Y, Koshima H, Okui N, Funahashi K, Ishikawa H, Inoue H, Asai S, Terabe K, Kishimoto K, Kihira D, Maeda M, Sato R, Imagama S. Relationship between frailty and methotrexate discontinuation due to adverse events in rheumatoid arthritis patients. Clin Rheumatol. 2023. DOI: 10.1007/s10067-023-06639-z
  47. Ouchida J, Ozaki T, Segi N, Suzuki Y, Imagama S, Kadomatsu K, Sakamoto K. Glypican-2 defines age-dependent axonal response to chondroitin sulfate. Exp Neurol. 2023. DOI: 10.1016/j.expneurol.2023.114444
  48. Matsuno Y, Takegami Y, Tokutake K, Takami H, Kurokawa H, Iwata M, Terasawa S, Yamauchi KI, Imagama S. Incidence and Risk Factors for Fracture-Related Infection After Peri-Prosthetic Femoral Fractures: A Multicenter Retrospective Study (TRON Group Study). Surg Infect (Larchmt). 2023. DOI: 10.1089/sur.2022.347
  49. Takeda S, Kurimoto S, Tanaka Y, Mitsuya S, Hirata H, Murakami H, Jianmongkol S, Okamoto H. Mid-term outcomes of digital nerve injuries treated with Renerve® synthetic collagen nerve conduits: A retrospective single-center study. J Orthop Sci. 2024. DOI: 10.1016/j.jos.2023.04.004
  50. Nakashima H, Imagama S, Yoshii T, Egawa S, Sakai K, Kusano K, Tsutsui S, Hirai T, Matsukura Y, Wada K, Katsumi K, Koda M, Kimura A, Furuya T, Maki S, Nagoshi N, Nishida N, Nagamoto Y, Oshima Y, Ando K, Takahata M, Mori K, Nakajima H, Murata K, Miyagi M, Kaito T, Yamada K, Banno T, Kato S, Ohba T, Moridaira H, Fujibayashi S, Katoh H, Kanno H, Taneichi H, Kawaguchi Y, Takeshita K, Nakamura M, Okawa A, Yamazaki M. Factors Associated With Loss of Cervical Lordosis After Laminoplasty for Patients With Cervical Ossification of the Posterior Longitudinal Ligament: Data From a Prospective Multicenter Study. Spine (Phila Pa 1976). 2023. DOI: 10.1097/BRS.0000000000004706
  51. Yamauchi I, Nakashima H, Machino M, Ito S, Segi N, Tauchi R, Ohara T, Kawakami N, Imagama S. Relationship between lumbosacral transitional vertebra and postoperative outcomes of patients with Lenke 5C adolescent idiopathic scoliosis: a minimum 5-year follow-up study. Eur Spine J. 2023. DOI: 10.1007/s00586-023-07752-y
  52. Kuwahara Y, Takegami Y, Mitsuya S, Tokutake K, Yamauchi K, Imagama S. Locked Tension Band Wiring for Mayo IIA Olecranon Fractures: Modified Surgical Technique and Retrospective Comparative Study of Clinical Outcomes and Cost-effectiveness with Locking Plate. J Hand Surg Asian Pac Vol. 2023. DOI: 10.1142/S2424835523500224
  53. Kagami Y, Nakashima H, Satake K, Ito K, Tsushima M, Segi N, Tomita H, Ouchida J, Morita Y, Ode Y, Imagama S, Kanemura T. Anatomical Analysis of the Gonadal Veins and Spine in Lateral Lumbar Interbody Fusion. J Clin Med. 2023. DOI: 10.3390/jcm12083041
  54. Suzuki M, Asai S, Hara R, Hirano Y, Nagamine S, Kaneko T, Sakane H, Okano T, Yoshioka Y, Tsuji S, Wakabayashi H, Takakubo Y, Takemoto T, Fujibayashi T, Watanabe T, Kato T, Ishikawa H, Nasu Y, Torikai E, Kaneko A, Takagi H, Fujiwara T, Kihira D, Hattori K, Kishimoto K, Ohashi Y, Sobue Y, Yokota Y, Nishiume T, Terabe K, Takahashi N, Kojima M, Imagama S, Kojima T. Choice of and response to treatment in patients with early-diagnosed rheumatoid arthritis: Real-world data from an inception cohort in Japan (NICER-J). J Orthop Sci. 2024. DOI: 10.1016/j.jos.2023.03.020
  55. Sugino T, Takegami Y, Bando K, Sato T, Fujita T, Oka Y, Imagama S. The Wait Time for Surgery Following Injury Affects Functional Outcomes and Complications After an Ankle Fracture: A Propensity Score-Matched Multicenter Study, the TRON Study. Foot Ankle Spec. 2024. DOI: 10.1177/19386400231164211
  56. Segi N, Nakashima H, Shinjo R, Kagami Y, Machino M, Ito S, Ouchida J, Morishita K, Oishi R, Yamauchi I, Imagama S. Trabecular Bone Remodeling After Posterior Lumbar Interbody Fusion: Comparison of Three-Dimensional Porous Tantalum and Titanium-Coated Polyetheretherketone Interbody Cages. Global Spine J. 2024. DOI: 10.1177/21925682231170613
  57. Oshika Y, Takegami Y, Tokutake K, Yokoyama H, Oguchi T, Imagama S. Ulnar Nerve Neuropathy After Surgery for Intraarticular Distal Humerus Fractures: An Analysis of 116 Patients. J Hand Surg Am. 2023. DOI: 10.1016/j.jhsa.2023.02.001
  58. Kawashima I, Matsushita M, Mishima K, Kamiya Y, Osawa Y, Ohkawara B, Ohno K, Kitoh H, Imagama S. Activated FGFR3 suppresses bone regeneration and bone mineralization in an ovariectomized mouse model. BMC Musculoskelet Disord. 2023. DOI: 10.1186/s12891-023-06318-9
  59. Palumbo F, Yamamoto M, Hirata H. Multiple tendon transfer for a case of radial nerve palsy in hereditary neuropathy with liability to pressure palsy. Nagoya J Med Sci. 2023. DOI: 10.18999/nagjms.85.1.204
  60. Ito S, Sakai Y, Ando K, Nakashima H, Machino M, Segi N, Tomita H, Koshimizu H, Hida T, Ito K, Harada A, Imagama S. ＜Editors' Choice＞ Neck pain after cervical laminoplasty is associated with postoperative atrophy of the trapezius muscle. Nagoya J Med Sci. 2023. DOI: 10.18999/nagjms.85.1.103
  61. Kagami Y, Nakashima H, Ito K, Satake K, Tsushima M, Ouchida J, Morita Y, Ode Y, Segi N, Imagama S, Kanemura T. The anatomical relationship between the celiac artery and the median arch ligament in degenerative spinal surgery. J Orthop Sci. 2024. DOI: 10.1016/j.jos.2023.02.015
  62. Ito S, Nakashima H, Machino M, Segi N, Ishizuka S, Takegami Y, Takeuchi J, Ouchida J, Hasegawa Y, Imagama S. Comparison of the Relationship between Visual Acuity and Motor Function in Non-Elderly and Elderly Adults. J Clin Med. 2023. DOI: 10.3390/jcm12052008
  63. Segi N, Nakashima H, Shinjo R, Kagami Y, Machino M, Ito S, Ouchida J, Imagama S. Reply to \"Letter to the Editor Concerning 'Trabecular Bone Remodeling as a New Indicator of Osteointegration After Posterior Lumbar Interbody Fusion.' by Segi et al.\". Global Spine J. 2024. DOI: 10.1177/21925682231162860
  64. Funahashi H, Osawa Y, Seki T, Takegami Y, Nishida K, Imagama S. Pelvic morphologies of developmental dysplasia and primary osteoarthritis on range of motion after total hip arthroplasty. J Orthop Res. 2023. DOI: 10.1002/jor.25544
  65. Murayama A, Yoneda H, Maehara A, Shiomi N, Hirata H. A highly elastic absorbable monofilament suture fabricated from poly(3-hydroxybutyrate-co-4-hydroxybutyrate). Sci Rep. 2023. DOI: 10.1038/s41598-023-30292-w
  66. Takemoto G, Osawa Y, Seki T, Takegami Y, Kato D, Okamoto M, Iida H, Imagama S. A large preoperative pelvic oblique angle affects perception of leg length discrepancy after total hip arthroplasty. J Orthop Sci. 2024. DOI: 10.1016/j.jos.2023.01.013
  67. Segi N, Nakashima H, Shinjo R, Kagami Y, Machino M, Ito S, Ouchida J, Morishita K, Oishi R, Yamauchi I, Imagama S. Vertebral Endplate Concavity in Lateral Lumbar Interbody Fusion: Tapered 3D-Printed Porous Titanium Cage versus Squared PEEK Cage. Medicina (Kaunas). 2023. DOI: 10.3390/medicina59020372
  68. Yamamoto S, Takegami Y, Tokutake K, Nakashima R, Naito K, Ogura K, Kato D, Imagama S. Effect of anaesthesia on cemented hemiarthroplasty -A multicentre retrospective study (TRON study). J Orthop Sci. 2024. DOI: 10.1016/j.jos.2023.02.005
  69. Mori Y, Takegami Y, Tokutake K, Oka Y, Imagama S. Retrospective Comparative Study of Clinical Outcomes and Cost-Effectiveness with Bone Substitutes on Volar Locking Plate Fixation of Unstable Distal Radial Fractures in the Elderly. J Hand Surg Asian Pac Vol. 2023. DOI: 10.1142/S2424835523500091
  70. Kamiya Y, Mishima K, Tanaka T, Sawamura K, Matsushita M, Imagama S. Acute osteomyelitis of the patella due to Pseudomonas aeruginosa in an immunocompetent child: A case report. Medicine (Baltimore). 2023. DOI: 10.1097/MD.0000000000033012
  71. Osawa Y, Seki T, Takegami Y, Kato D, Takemoto G, Imagama S. Factors affecting sports participation after total hip arthroplasty. Int Orthop. 2023. DOI: 10.1007/s00264-023-05724-x
  72. Fujihara Y, Yamamoto M, Hidaka S, Sakai A, Hirata H. Vascularised versus non-vascularised bone graft for scaphoid nonunion: Meta-analysis of randomised controlled trials and comparative studies. JPRAS Open. 2023. DOI: 10.1016/j.jpra.2022.12.001
  73. Ito S, Sakai Y, Ando K, Nakashima H, Machino M, Segi N, Tomita H, Koshimizu H, Hida T, Ito K, Harada A, Imagama S. Association between Postoperative Neck Pain and Intraoperative Transcranial Motor-Evoked Potential Waveforms of the Trapezius Muscles in Patients with Cervical Myelopathy Who Underwent Cervical Laminoplasty. Asian Spine J. 2023. DOI: 10.31616/asj.2022.0120
  74. Ito S, Nakashima H, Yoshii T, Egawa S, Sakai K, Kusano K, Tsutui S, Hirai T, Matsukura Y, Wada K, Katsumi K, Koda M, Kimura A, Furuya T, Maki S, Nagoshi N, Nishida N, Nagamoto Y, Oshima Y, Ando K, Takahata M, Mori K, Nakajima H, Murata K, Miyagi M, Kaito T, Yamada K, Banno T, Kato S, Ohba T, Inami S, Fujibayashi S, Katoh H, Kanno H, Oda M, Mori K, Taneichi H, Kawaguchi Y, Takeshita K, Matsumoto M, Yamazaki M, Okawa A, Imagama S. Deep learning-based prediction model for postoperative complications of cervical posterior longitudinal ligament ossification. Eur Spine J. 2023. DOI: 10.1007/s00586-023-07562-2
  75. Shibata R, Tokutake K, Takegami Y, Natsume T, Matsubara Y, Imagama S. Comparison of surgical treatments for distal ulna fracture when combined with anterior locking plate fixation of distal radius in the over 70 age group. J Hand Surg Eur Vol. 2023. DOI: 10.1177/17531934221150495
  76. Sakai T, Okuno Y, Murakami N, Shimoyama Y, Imagama S, Nishida Y. Case report: Novel NIPBL-BEND2 fusion gene identified in osteoblastoma-like phosphaturic mesenchymal tumor of the fibula. Front Oncol. 2022. DOI: 10.3389/fonc.2022.956472
  77. Kurokawa H, Takegami Y, Tokutake K, Takami H, Iwata M, Terasawa S, Inoue H, Imagama S. Predictive factors for one-year mortality after surgery for periprosthetic femoral fracture: A retrospective multicenter (TRON group) study. J Orthop Sci. 2024. DOI: 10.1016/j.jos.2022.12.015
  78. Sakurai S, Takegami Y, Tokutake K, Kuwahara Y, Shibata R, Ota H, Kumagai H, Imagama S. Are the Clinical Results of Locking Plate Fixation for Distal Radius Fractures Inferior in Patients over 80 Years of Age? A Multicentre (TRON Group) Study. Indian J Orthop. 2023. DOI: 10.1007/s43465-022-00788-0
  79. Kishimoto K, Kojima T, Takahashi N, Asai S, Terabe K, Suzuki M, Ohashi Y, Kihira D, Maeda M, Tatebe M, Imagama S. Periprosthetic humeral fracture revision using a massive allograft in a patient with rheumatoid arthritis: A case report. Mod Rheumatol Case Rep. 2023. DOI: 10.1093/mrcr/rxad001
  80. Takami H, Takegami Y, Tokutake K, Kurokawa H, Iwata M, Terasawa S, Oguchi T, Imagama S. Mortality and clinical outcomes of Vancouver type B periprosthetic femoral fractures : a multicentre retrospective study. Bone Jt Open. 2023. DOI: 10.1302/2633-1462.41.BJO-2022-0145.R1
  81. Ohshima K, Tokutake K, Takegami Y, Asami Y, Matsubara Y, Natsume T, Kimura Y, Ishihara N, Imagama S. Longer time of implantation using the buried pin technique for intramedullary nailing would decrease refracture in the diaphyseal forearm fracture in children-retrospective multicenter (TRON) study. Injury. 2023. DOI: 10.1016/j.injury.2023.01.025
  82. Segi N, Nakashima H, Machino M, Ito S, Yokogawa N, Sasagawa T, Funayama T, Eto F, Watanabe K, Nori S, Furuya T, Yunde A, Nakajima H, Hasegawa T, Yamada T, Terashima Y, Hirota R, Suzuki H, Imajo Y, Ikegami S, Uehara M, Tonomura H, Sakata M, Hashimoto K, Onoda Y, Kawaguchi K, Haruta Y, Suzuki N, Kato K, Uei H, Sawada H, Nakanishi K, Misaki K, Terai H, Tamai K, Inoue G, Shirasawa E, Kakutani K, Iizuka Y, Takasawa E, Akeda K, Kiyasu K, Tominaga H, Tokumoto H, Funao H, Oshima Y, Yoshii T, Kaito T, Sakai D, Ohba T, Seki S, Otsuki B, Ishihara M, Miyazaki M, Okada S, Imagama S, Kato S. Epidemiology of Cervical Fracture/Cervical Spinal Cord Injury and Changes in Surgical Treatment Modalities in Elderly Individuals During a 10-year Period: A Nationwide Multicenter Study in Japan. Global Spine J. 2024. DOI: 10.1177/21925682231151643
  83. Kamiya Y, Matsushita M, Mishima K, Ohkawara B, Michigami T, Imagama S, Ohno K, Kitoh H. Meclozine ameliorates bone mineralization and growth plate structure in a mouse model of X‑linked hypophosphatemia. Exp Ther Med. 2023. DOI: 10.3892/etm.2022.11738
  84. Tanaka K, Takegami Y, Tokutake K, Oshika Y, Iwase K, Yokoyama H, Taguchi K, Imagama S. A less invasive operative method using a medial cannulated cancellous screw and single plate fixation for the treatment of transcondylar fracture of the humerus in elderly patients in multicenter (TRON group) study. Eur J Orthop Surg Traumatol. 2023. DOI: 10.1007/s00590-022-03464-z
  85. Yokoyama H, Takegami Y, Tokutake K, Oshika Y, Iwase K, Tanaka K, Kanemura T, Imagama S. Clinical comparison of double-plate fixation by the perpendicular plate method versus parallel plate method for distal humeral fracture: a multicenter (TRON group) study. Eur J Orthop Surg Traumatol. 2023. DOI: 10.1007/s00590-022-03462-1
  86. Ando K, Machino M, Ito S, Segi N, Tomita H, Koshimizu H, Imagama S. Surgical outcomes in instrumented surgery for dumbbell type spinal cord tumor -the comparison with non-instrumented surgery for spinal cord tumor. J Orthop Sci. 2023. DOI: 10.1016/j.jos.2022.10.026
  87. Kato D, Takegami Y, Seki T, Osawa Y, Takemoto G, Okamoto M, Iida H, Imagama S. Differences in peri-hip articular pain after total hip arthroplasty between taper wedge stem and fit-and-fill stem. J Orthop. 2023. DOI: 10.1016/j.jor.2022.10.014
  88. Ouchida J, Nakashima H, Kanemura T, Okamoto M, Hatsushikano S, Imagama S, Le Huec JC, Hasegawa K. The age-specific normative values of standing whole-body sagittal alignment parameters in healthy adults: based on international multicenter data. Eur Spine J. 2023. DOI: 10.1007/s00586-022-07445-y
  89. Ito S, Nakashima H, Sato K, Deguchi M, Matsubara Y, Kanemura T, Urasaki T, Yoshihara H, Sakai Y, Ito K, Shinjo R, Ando K, Machino M, Segi N, Tomita H, Koshimizu H, Imagama S. Laterality of lumbar disc herniation. J Orthop Sci. 2023. DOI: 10.1016/j.jos.2022.10.003
  90. Osawa Y, Seki T, Takegami Y, Makida K, Ochiai S, Hasegawa Y, Imagama S. Factors affecting return to sports after eccentric rotational acetabular osteotomy. Orthop Traumatol Surg Res. 2023. DOI: 10.1016/j.otsr.2022.103442
  91. Sakai T, Nishida Y, Ito K, Ikuta K, Urakawa H, Koike H, Imagama S. Clinical results of active surveillance for extra-abdominal desmoid-type fibromatosis. Cancer Med. 2023. DOI: 10.1002/cam4.5329
  92. Asai S, Takahashi N, Kishimoto K, Suzuki M, Ohashi Y, Terabe K, Kojima T, Imagama S. Increased prevalence of Staphylococcus aureus nasal carriage in rheumatoid arthritis patients with moderate/high disease activity. J Orthop Sci. 2023. DOI: 10.1016/j.jos.2022.09.014
  93. Osawa Y, Takegami Y, Kato D, Okamoto M, Iida H, Imagama S. Hip function in patients undergoing conservative treatment for osteonecrosis of the femoral head. Int Orthop. 2023. DOI: 10.1007/s00264-022-05569-w
  94. Terabe K, Takahashi N, Asai S, Hirano Y, Kanayama Y, Yabe Y, Oguchi T, Fujibayashi T, Ishikawa H, Hanabayashi M, Hattori Y, Suzuki M, Kishimoto K, Ohashi Y, Imaizumi T, Imagama S, Kojima T. Reasons and risk factors for discontinuation of treatment with any biological disease-modifying antirheumatic drugs in patients with rheumatoid arthritis: A long-term observational study. Mod Rheumatol. 2023. DOI: 10.1093/mr/roac090
  95. Katayama Y, Takegami Y, Tokutake K, Okui N, Sakai T, Takahashi H, Imagama S. Comparison of functional outcome and complications of locking plate versus coracoclavicular fixation in the treatment of unstable distal clavicle fractures: the multicenter, propensity-matched TRON study. Eur J Orthop Surg Traumatol. 2023. DOI: 10.1007/s00590-022-03358-0
  96. Kishimoto K, Asai S, Suzuki M, Takahashi N, Terabe K, Ohashi Y, Hattori K, Kojima T, Imagama S. Age and symptoms at onset of ankylosing spondylitis in Japanese patients. Mod Rheumatol. 2023. DOI: 10.1093/mr/roac081
  97. Nakashima H, Yoneda M, Machino M, Ito S, Segi N, Tomita H, Ouchida J, Imagama S. Utility of ultrasonography in the diagnosis of lumbar spondylolysis in adolescent patients. J Orthop Sci. 2023. DOI: 10.1016/j.jos.2022.06.019
  98. Iwatsuki K, Hashizume H, Hara Y, Okui N, Morizaki Y, Tada K, Matsui Y, Ishii H, Hirata H. Questionnaire survey about the effects of new lifestyles during the pandemic of COVID-19 on upper limb diseases. J Orthop Sci. 2023. DOI: 10.1016/j.jos.2022.06.005
  99. Hattori K, Takahashi N, Kojima T, Imagama S. Risk factors for denosumab discontinuation in patients with postmenopausal osteoporosis. Mod Rheumatol. 2023. DOI: 10.1093/mr/roac070
  100. Zhang J, Nishida Y, Koike H, Ito K, Zhuo L, Nishida K, Kimata K, Ikuta K, Sakai T, Urakawa H, Seki T, Imagama S. Hyaluronan in articular cartilage: Analysis of hip osteoarthritis and osteonecrosis of femoral head. J Orthop Res. 2023. DOI: 10.1002/jor.25364
  101. Ohashi Y, Takahashi N, Sobue Y, Suzuki M, Hattori K, Kishimoto K, Terabe K, Asai S, Kojima T, Kojima M, Imagama S. Factors associated with frailty in rheumatoid arthritis patients with decreased renal function. Mod Rheumatol. 2023. DOI: 10.1093/mr/roac018
  102. Kanbara S, Ando K, Kobayashi K, Nakashima H, Machino M, Seki T, Ishizuka S, Ito S, Inoue T, Yamaguchi H, Koshimizu H, Segi N, Tomita H, Hasegawa Y, Imagama S. Metabolic syndrome reduces spinal range of motion: The Yakumo study. J Orthop Sci. 2023. DOI: 10.1016/j.jos.2022.02.008
  103. Nakano T, Kurimoto S, Ishii H, Iwatsuki K, Yamamoto M, Tatebe M, Hirata H. Mast cell presence in tendon sheaths of trigger fingers: implications on pathogenesis and clinical presentation. J Plast Surg Hand Surg. 2023. DOI: 10.1080/2000656X.2022.2061498
  104. Bando K, Takegami Y, Ando T, Sugino T, Sato T, Fujita T, Imagama S. Early weight bearing and mobilization decrease perioperative complications in patients after ankle fracture; the retrospective multicenter (TRON group) study. J Orthop Sci. 2023. DOI: 10.1016/j.jos.2022.03.002
  105. Hattori K, Takahashi N, Suzuki M, Kojima T, Imagama S. A case of synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome with isolated lesions of the thoracic spine. Mod Rheumatol Case Rep. 2023. DOI: 10.1093/mrcr/rxac030
  106. Terabe K, Takahashi N, Asai S, Hirano Y, Kanayama Y, Yabe Y, Oguchi T, Fujibayashi T, Ishikawa H, Hanabayashi M, Hattori Y, Suzuki M, Kishimoto K, Ohashi Y, Imaizumi T, Imagama S, Kojima T. Effectiveness of tacrolimus concomitant with biological disease-modifying antirheumatic drugs in patients with rheumatoid arthritis. Mod Rheumatol. 2023. DOI: 10.1093/mr/roac025
  107. Kuwahara Y, Takegami Y, Tokutake K, Yamada Y, Komaki K, Imagama S. Low body mass index is a risk factor for increased post-operative mortality and poor functional improvement in distal femur fractures among patients aged over 65: A multicentre (TRON) study. J Orthop Sci. 2023. DOI: 10.1016/j.jos.2022.01.014
  108. Hattori K, Takahashi N, Kojima T, Imagama S. Predictive factors for achievement of treatment goals in patients with postmenopausal osteoporosis treated with denosumab. Mod Rheumatol. 2023. DOI: 10.1093/mr/roab129
  109. Tatebe M, Yamamoto M, Kurimoto S, Iwatsuki K, Yoneda H, Hirata H. Do triangular fibrocartilage complex foveal injuries affect the clinical outcome of ulnar shortening osteotomy for ulnar impaction syndrome? J Orthop Sci. 2023. DOI: 10.1016/j.jos.2021.11.016
  110. Kawashima I, Hiraiwa H, Ishizuka S, Oba H, Sakaguchi T, Idota M, Kawai R, Tsukahara T, Imagama S. Displaced tibial and fibular stress fractures in a female elite pole-vaulter with menstrual dysfunction, vitamin D deficiency, and high serum pentosidine. J Orthop Sci. 2023. DOI: 10.1016/j.jos.2021.08.019
  111. Segi N, Nakashima H, Ando K, Kobayashi K, Seki T, Ishizuka S, Takegami Y, Machino M, Ito S, Koshimizu H, Tomita H, Hasegawa Y, Imagama S. Spinopelvic Imbalance Is Associated With Increased Sway in the Center of Gravity: Validation of the \"Cone of Economy\" Concept in Healthy Subjects. Global Spine J. 2023. DOI: 10.1177/21925682211038897
  112. Nakashima H, Kawakami N, Ohara T, Saito T, Tauchi R, Imagama S. Cervical Spinal Cord Compression in Adult Scoliosis. Global Spine J. 2023. DOI: 10.1177/21925682211041979
  113. Koshimizu H, Ando K, Kobayashi K, Nakashima H, Machino M, Ito S, Kanbara S, Inoue T, Yamaguchi H, Imagama S. Intramedullary cavernous hemangioma of the spinal cord with intra- and extramedullary hematomas. J Orthop Sci. 2023. DOI: 10.1016/j.jos.2020.10.003

• 2022

  1. Fujihara Y, Yamamoto M, Hidaka S, Sakai A, Hirata H. Vascularised versus non-vascularised bone graft for scaphoid nonunion: Meta-analysis of randomised controlled trials and comparative studies. JPRAS Open. 2023. DOI: 10.1016/j.jpra.2022.12.001
  2. Sakai T, Okuno Y, Murakami N, Shimoyama Y, Imagama S, Nishida Y. Case report: Novel NIPBL-BEND2 fusion gene identified in osteoblastoma-like phosphaturic mesenchymal tumor of the fibula. Front Oncol. 2022. DOI: 10.3389/fonc.2022.956472
  3. Sakurai S, Takegami Y, Tokutake K, Kuwahara Y, Shibata R, Ota H, Kumagai H, Imagama S. Are the Clinical Results of Locking Plate Fixation for Distal Radius Fractures Inferior in Patients over 80 Years of Age? A Multicentre (TRON Group) Study. Indian J Orthop. 2023. DOI: 10.1007/s43465-022-00788-0
  4. Wada K, Imagama S, Matsuyama Y, Yoshida G, Ando K, Kobayashi K, Machino M, Kawabata S, Iwasaki H, Funaba M, Kanchiku T, Yamada K, Fujiwara Y, Shigematsu H, Taniguchi S, Ando M, Takahashi M, Ushirozako H, Tadokoro N, Morito S, Yamamoto N, Yasuda A, Hashimoto J, Takatani T, Tani T, Kumagai G, Asari T, Nitobe Y, Ishibashi Y. Comparison of intraoperative neuromonitoring accuracies and procedures associated with alarms in anterior versus posterior fusion for cervical spinal disorders: A prospective multi-institutional cohort study. Medicine (Baltimore). 2022. DOI: 10.1097/MD.0000000000031846
  5. Kamiya Y, Matsushita M, Mishima K, Ohkawara B, Michigami T, Imagama S, Ohno K, Kitoh H. Meclozine ameliorates bone mineralization and growth plate structure in a mouse model of X‑linked hypophosphatemia. Exp Ther Med. 2023. DOI: 10.3892/etm.2022.11738
  6. Yoneda H, Hara T, Iwatsuki K, Yamamoto M, Tatebe M, Hirata H. Can on-top plasty for atypical radial polydactyly realize a functional reconstruction corresponding to appearance? Nagoya J Med Sci. 2022. DOI: 10.18999/nagjms.84.4.705
  7. Yoshida A, Yamamoto M, Li-Tsang CWP, Iwatsuki K, Hirata H. A systematic review assessing the effectiveness of hand therapy programmes in adults with burns using the International Classification of Functioning, Disability and Health framework. Nagoya J Med Sci. 2022. DOI: 10.18999/nagjms.84.4.689
  8. Sobue Y, Suzuki M, Ohashi Y, Koshima H, Okui N, Funahashi K, Ishikawa H, Inoue H, Kojima M, Asai S, Terabe K, Hattori K, Kishimoto K, Takahashi N, Imagama S, Kojima T. Locomotive syndrome in rheumatoid arthritis patients during the COVID-19 pandemic. Nagoya J Med Sci. 2022. DOI: 10.18999/nagjms.84.4.799
  9. Tanaka K, Takegami Y, Tokutake K, Oshika Y, Iwase K, Yokoyama H, Taguchi K, Imagama S. A less invasive operative method using a medial cannulated cancellous screw and single plate fixation for the treatment of transcondylar fracture of the humerus in elderly patients in multicenter (TRON group) study. Eur J Orthop Surg Traumatol. 2023. DOI: 10.1007/s00590-022-03464-z
  10. Yokoyama H, Takegami Y, Tokutake K, Oshika Y, Iwase K, Tanaka K, Kanemura T, Imagama S. Clinical comparison of double-plate fixation by the perpendicular plate method versus parallel plate method for distal humeral fracture: a multicenter (TRON group) study. Eur J Orthop Surg Traumatol. 2023. DOI: 10.1007/s00590-022-03462-1
  11. Iida H, Seki T, Takegami Y, Osawa Y, Kato D, Takemoto G, Ando K, Ishizuka S, Hasegawa Y, Imagama S. Association between locomotive syndrome and fall risk in the elderly individuals in Japan: The Yakumo study. J Orthop Sci. 2024. DOI: 10.1016/j.jos.2022.11.023
  12. Kagami Y, Tokutake K, Takegami Y, Okui N, Sakai T, Inoue H, Kanemura T, Hanabayashi M, Ito O, Kanayama Y, Maruyama K, Yoshida H, Ando T, Sugimoto R, Sugimoto T, Imagama S. Do heel-unloading orthoses improve clinical outcomes in patients after surgical treatment of calcaneal fracture? A propensity-matched, multicenter analysis of the TRON database. Prosthet Orthot Int. 2022. DOI: 10.1097/PXR.0000000000000168
  13. Ando K, Machino M, Ito S, Segi N, Tomita H, Koshimizu H, Imagama S. Surgical outcomes in instrumented surgery for dumbbell type spinal cord tumor -the comparison with non-instrumented surgery for spinal cord tumor. J Orthop Sci. 2023. DOI: 10.1016/j.jos.2022.10.026
  14. Shibata R, Takeda S, Yamauchi KI, Hirata H. Use of Triceps Tendon and Paratenon Composite Graft for Extensor Tendon Reconstruction in the Hand: A Case Report. J Hand Surg Asian Pac Vol. 2022. DOI: 10.1142/S2424835522720493
  15. Sobue Y, Suzuki M, Ohashi Y, Koshima H, Okui N, Funahashi K, Ishikawa H, Inoue H, Kojima M, Asai S, Terabe K, Kishimoto K, Maeda M, Kihira D, Imagama S, Kojima T. Validation of grip strength as a measure of frailty in rheumatoid arthritis. Sci Rep. 2022. DOI: 10.1038/s41598-022-21533-5
  16. Ohashi Y, Takahashi N, Sobue Y, Suzuki M, Hattori K, Kishimoto K, Terabe K, Asai S, Kojima T, Kojima M, Imagama S. Disease activity at baseline is an independent predictor of frailty at one year in pre-frail patients with rheumatoid arthritis; a multicenter retrospective observational study. J Orthop Sci. 2024. DOI: 10.1016/j.jos.2022.10.025
  17. Mishima K, Okabe YT, Mizuno M, Ohno K, Kitoh H, Imagama S. Efficacy of soluble lansoprazole-impregnated beta-tricalcium phosphate for bone regeneration. Sci Rep. 2022. DOI: 10.1038/s41598-022-25184-4
  18. Komaki K, Takegami Y, Tokutake K, Hanabayashi M, Kuwahara Y, Yamada Y, Imagama S. Early weight bearing versus late weight bearing after intramedullary nailing for distal femoral fracture (AO/OTA 33) in elderly patients: A multicenter propensity-matched study. J Orthop Sci. 2024. DOI: 10.1016/j.jos.2022.10.023
  19. Kato D, Takegami Y, Seki T, Osawa Y, Takemoto G, Okamoto M, Iida H, Imagama S. Differences in peri-hip articular pain after total hip arthroplasty between taper wedge stem and fit-and-fill stem. J Orthop. 2023. DOI: 10.1016/j.jor.2022.10.014
  20. Ouchida J, Nakashima H, Kanemura T, Okamoto M, Hatsushikano S, Imagama S, Le Huec JC, Hasegawa K. The age-specific normative values of standing whole-body sagittal alignment parameters in healthy adults: based on international multicenter data. Eur Spine J. 2023. DOI: 10.1007/s00586-022-07445-y
  21. Ito S, Nakashima H, Sato K, Deguchi M, Matsubara Y, Kanemura T, Urasaki T, Yoshihara H, Sakai Y, Ito K, Shinjo R, Ando K, Machino M, Segi N, Tomita H, Koshimizu H, Imagama S. Laterality of lumbar disc herniation. J Orthop Sci. 2023. DOI: 10.1016/j.jos.2022.10.003
  22. Saeki M, Oyama S, Yoneda H, Shimoda S, Agata T, Handa Y, Kaneda S, Hirata H. Demonstration experiment of telemedicine using ultrasonography and telerehabilitation with 5G communication system in aging and depopulated mountainous area. Digit Health. 2022. DOI: 10.1177/20552076221129074
  23. Osawa Y, Seki T, Takegami Y, Makida K, Ochiai S, Hasegawa Y, Imagama S. Factors affecting return to sports after eccentric rotational acetabular osteotomy. Orthop Traumatol Surg Res. 2023. DOI: 10.1016/j.otsr.2022.103442
  24. Koshimizu H, Nakashima H, Ando K, Kobayashi K, Nishimura Y, Machino M, Ito S, Kanbara S, Inoue T, Yamaguchi H, Segi N, Tomita H, Imagama S. Patient factors influencing a delay in diagnosis in pediatric spinal cord tumors. Nagoya J Med Sci. 2022. DOI: 10.18999/nagjms.84.3.516
  25. Takeda S, Yoneda H, Tatebe M, Kurahashi T, Mitsuya S, Hirata H. Satisfactory mid- to long-term clinical and radiographic outcomes after surgical treatment of radial neck fracture in 10 children. Nagoya J Med Sci. 2022. DOI: 10.18999/nagjms.84.3.539
  26. Segi N, Nakashima H, Ando K, Machino M, Ito S, Matsumoto A, Koshimizu H, Tomita H, Nojima T, Imagama S. Paraplegia due to spinal epidural lipoma without spinal dysraphism in an adolescent patient: a case report. Nagoya J Med Sci. 2022. DOI: 10.18999/nagjms.84.3.656
  27. Mizuno T, Hosoyama T, Tomida M, Yamamoto Y, Nakamichi Y, Kato S, Kawai-Takaishi M, Ishizuka S, Nishita Y, Tange C, Shimokata H, Imagama S, Otsuka R. Influence of vitamin D on sarcopenia pathophysiology: A longitudinal study in humans and basic research in knockout mice. J Cachexia Sarcopenia Muscle. 2022. DOI: 10.1002/jcsm.13102
  28. Takeuchi M, Tokutake K, Watanabe K, Ito N, Aoyama T, Saeki S, Kurimoto S, Hirata H, Hasegawa Y. A Wirelessly Powered 4-Channel Neurostimulator for Reconstructing Walking Trajectory. Sensors (Basel). 2022. DOI: 10.3390/s22197198
  29. Ikuta K, Nishida Y, Sakai T, Koike H, Ito K, Urakawa H, Imagama S. Surgical Treatment and Complications of Deep-Seated Nodular Plexiform Neurofibromas Associated with Neurofibromatosis Type 1. J Clin Med. 2022. DOI: 10.3390/jcm11195695
  30. Sakai T, Nishida Y, Ito K, Ikuta K, Urakawa H, Koike H, Imagama S. Clinical results of active surveillance for extra-abdominal desmoid-type fibromatosis. Cancer Med. 2023. DOI: 10.1002/cam4.5329
  31. Asai S, Takahashi N, Kishimoto K, Suzuki M, Ohashi Y, Terabe K, Kojima T, Imagama S. Increased prevalence of Staphylococcus aureus nasal carriage in rheumatoid arthritis patients with moderate/high disease activity. J Orthop Sci. 2023. DOI: 10.1016/j.jos.2022.09.014
  32. Ikuta K, Nishida Y, Ota T, Tsukushi S, Kozawa E, Nakashima H, Yamada K, Yamashita S, Imagama S. A clinical trial of a unidirectional porous tricalcium phosphate filling for defects after resection of benign bone lesions: a prospective multicenter study. Sci Rep. 2022. DOI: 10.1038/s41598-022-20359-5
  33. Osawa Y, Takegami Y, Kato D, Okamoto M, Iida H, Imagama S. Hip function in patients undergoing conservative treatment for osteonecrosis of the femoral head. Int Orthop. 2023. DOI: 10.1007/s00264-022-05569-w
  34. Yamamoto M, Curley J, Hirata H. Trends in Open vs. Endoscopic Carpal Tunnel Release: A Comprehensive Survey in Japan. J Clin Med. 2022. DOI: 10.3390/jcm11174966
  35. Okamoto M, Seki T, Takegami Y, Osawa Y, Imagama S. Effect of trochanter displacement on impingement and bone contact in total hip arthroplasty performed after curved intertrochanteric varus osteotomy for osteonecrosis of the femoral head: a simulation study. BMC Musculoskelet Disord. 2022. DOI: 10.1186/s12891-022-05803-x
  36. Kato D, Matsushita M, Takegami Y, Mishima K, Kamiya N, Osawa Y, Imagama S, Kitoh H. Gain-of-Function of FGFR3 Accelerates Bone Repair Following Ischemic Osteonecrosis in Juvenile Mice. Calcif Tissue Int. 2022. DOI: 10.1007/s00223-022-01019-2
  37. Machino M, Nakashima H, Ito K, Tsushima M, Ando K, Kobayashi K, Imagama S. Influence of Age and Gender on Intervertebral Disk Degeneration and Height in the Thoracolumbar Spine. Spine Surg Relat Res. 2022. DOI: 10.22603/ssrr.2021-0187
  38. Ouchida J, Nakashima H, Kanemura T, Satake K, Ito K, Tsushima M, Ando K, Machino M, Ito S, Segi N, Morita Y, Ode Y, Imagama S. Impact of Adjacent Facet Joint Osteoarthritis on Adjacent Segment Degeneration after Short-Segment Lateral Lumbar Interbody Fusion for Indirect Decompression: Minimum 5-Year Follow-Up. Biomed Res Int. 2022. DOI: 10.1155/2022/3407681
  39. Sobue Y, Suzuki M, Ohashi Y, Koshima H, Okui N, Funahashi K, Ishikawa H, Inoue H, Kojima M, Asai S, Terabe K, Hattori K, Kishimoto K, Takahashi N, Imagama S, Kojima T. Association between locomotive syndrome and methotrexate discontinuation due to adverse events in rheumatoid arthritis patients: A retrospective observational study. Geriatr Gerontol Int. 2022. DOI: 10.1111/ggi.14475
  40. Machino M, Sakai K, Yoshii T, Furuya T, Ito S, Segi N, Ouchida J, Imagama S, Nakashima H. Treatment for the Thoracic Ossification of the Posterior Longitudinal Ligament and Ossification of the Ligamentum Flavum. J Clin Med. 2022. DOI: 10.3390/jcm11164690
  41. Katayama Y, Takegami Y, Tokutake K, Okui N, Sakai T, Takahashi H, Imagama S. Comparison of functional outcome and complications of locking plate versus coracoclavicular fixation in the treatment of unstable distal clavicle fractures: the multicenter, propensity-matched TRON study. Eur J Orthop Surg Traumatol. 2023. DOI: 10.1007/s00590-022-03358-0
  42. Saeki S, Tokutake K, Takasu M, Kurimoto S, Asami Y, Onaka K, Saeki M, Hirata H. Functional Reconstruction of Denervated Muscle by Xenotransplantation of Neural Cells from Porcine to Rat. Int J Mol Sci. 2022. DOI: 10.3390/ijms23158773
  43. Tokutake K, Takeuchi M, Kurimoto S, Saeki S, Asami Y, Onaka K, Saeki M, Aoyama T, Hasegawa Y, Hirata H. A Therapeutic Strategy for Lower Motor Neuron Disease and Injury Integrating Neural Stem Cell Transplantation and Functional Electrical Stimulation in a Rat Model. Int J Mol Sci. 2022. DOI: 10.3390/ijms23158760
  44. Nakashima H, Yoneda M, Machino M, Ito S, Segi N, Tomita H, Ouchida J, Imagama S. Utility of ultrasonography in the diagnosis of lumbar spondylolysis in adolescent patients. J Orthop Sci. 2023. DOI: 10.1016/j.jos.2022.06.019
  45. Kuriyama K, Matsui Y, Suzuki Y, Mizuno T, Watanabe T, Takemura M, Ishizuka S, Yamashita S, Imagama S, Arai H. Relationship between sarcopenia classification and thigh muscle mass, fat area, muscle CT value and osteoporosis in middle-aged and older Japanese adults. Bone. 2022. DOI: 10.1016/j.bone.2022.116487
  46. Ito K, Nishida Y, Hamada S, Shimizu K, Sakai T, Ohkawara B, Alman BA, Enomoto A, Ikuta K, Koike H, Zhang J, Ohno K, Imagama S. Efficacy of auranofin as an inhibitor of desmoid progression. Sci Rep. 2022. DOI: 10.1038/s41598-022-15756-9
  47. Koshimizu H, Nakashima H, Tomita H, Segi N, Ito S, Machino M, Ando K, Imagama S. Pedicular kinking during posterior corrective procedure for thoracolumbar kyphoscoliosis with unstable osteoporotic fracture. J Orthop Sci. 2024. DOI: 10.1016/j.jos.2022.06.007
  48. Iwatsuki K, Hashizume H, Hara Y, Okui N, Morizaki Y, Tada K, Matsui Y, Ishii H, Hirata H. Questionnaire survey about the effects of new lifestyles during the pandemic of COVID-19 on upper limb diseases. J Orthop Sci. 2023. DOI: 10.1016/j.jos.2022.06.005
  49. Ouchida J, Nakashima H, Kanemura T, Satake K, Ando K, Ito K, Tsushima M, Machino M, Ito S, Yamaguchi H, Segi N, Koshimizu H, Tomita H, Imagama S. Impact of the hip joint mobility on whole-body sagittal alignment: prospective analysis in case with hip arthroplasty. Eur Spine J. 2022. DOI: 10.1007/s00586-022-07251-6
  50. Machino M, Nakashima H, Ito K, Ando K, Ito S, Kato F, Imagama S. Association between Occupation and Cervical Disc Degeneration in 1211 Asymptomatic Subjects. J Clin Med. 2022. DOI: 10.3390/jcm11123301
  51. Yamamoto M, Kato Y, Nakagawa Y, Hirata H, Takeuchi J. Predictive factors and clinical effects of diabetic hand: A prospective study with 1-year follow-up. J Plast Reconstr Aesthet Surg. 2022. DOI: 10.1016/j.bjps.2022.04.085
  52. Oyama S, Saeki M, Kaneta S, Shimoda S, Yoneda H, Hirata H. Telerehabilitation Based on Markerless Motion Capture and IMT-2020 (5G) Networks. Stud Health Technol Inform. 2022. DOI: 10.3233/SHTI220291
  53. Yamamoto M, Yasunaga H, Kakinoki R, Tsubokawa N, Morita A, Tanaka K, Sakai A, Kurahashi T, Hirata H. The CeCORD-J study on collagenase injection versus aponeurectomy for Dupuytren's contracture compared by hand function and cost effectiveness. Sci Rep. 2022. DOI: 10.1038/s41598-022-12966-z
  54. Makihara K, Takegami Y, Tokutake K, Yamauchi K, Hiramatsu Y, Matsuura Y, Imagama S. Risk factors for fracture-related infection after open reduction and internal fixation of proximal humerus fractures: A multicenter retrospective study of 496 fractures (TRON group study). Injury. 2022. DOI: 10.1016/j.injury.2022.05.022
  55. Hiramatsu Y, Takegami Y, Katsuhiro T, Matsuura Y, Makihara K, Kanemura T, Imagama S. Displaced humeral head after intramedullary nailing for proximal humeral fracture is associated with worse short-term outcomes-a multicenter TRON study. JSES Int. 2022. DOI: 10.1016/j.jseint.2021.12.009
  56. Otaka K, Osawa Y, Seki T, Inoue H, Imagama S. Total hip arthroplasty and autologous bone grafting for treating bilateral osteonecrosis of the acetabulum: A case report. J Orthop Sci. 2024. DOI: 10.1016/j.jos.2022.04.004
  57. Segi N, Ozaki T, Suzuki Y, Ouchida J, Imagama S, Kadomatsu K, Sakamoto K. Close association of polarization and LC3, a marker of autophagy, in axon determination in mouse hippocampal neurons. Exp Neurol. 2022. DOI: 10.1016/j.expneurol.2022.114112
  58. Zhang J, Nishida Y, Koike H, Ito K, Zhuo L, Nishida K, Kimata K, Ikuta K, Sakai T, Urakawa H, Seki T, Imagama S. Hyaluronan in articular cartilage: Analysis of hip osteoarthritis and osteonecrosis of femoral head. J Orthop Res. 2023. DOI: 10.1002/jor.25364
  59. Takegami Y, Seki T, Osawa Y, Imagama S. Comparison of periprosthetic femoral fracture torque and strain pattern of three types of femoral components in experimental model. Bone Joint Res. 2022. DOI: 10.1302/2046-3758.115.BJR-2021-0375.R2
  60. Saeki M, Yamamoto M, Tatebe M, Kurimoto S, Yoneda H, Hirata H. Postoperative magnetic resonance imaging following lunate resection and vascularized os pisiform transfer in Kienböck's disease. J Plast Reconstr Aesthet Surg. 2022. DOI: 10.1016/j.bjps.2022.04.016
  61. Takemoto G, Osawa Y, Seki T, Takegami Y, Ochiai S, Kato D, Imagama S. Factors influencing inconsistent leg length discrepancy in dysplastic hip osteoarthritis: a retrospective study. BMC Musculoskelet Disord. 2022. DOI: 10.1186/s12891-022-05348-z
  62. Koike H, Nishida Y, Shinomura T, Ohkawara B, Ohno K, Zhuo L, Kimata K, Ushida T, Imagama S. Possible Repositioning of an Oral Anti-Osteoporotic Drug, Ipriflavone, for Treatment of Inflammatory Arthritis via Inhibitory Activity of KIAA1199, a Novel Potent Hyaluronidase. Int J Mol Sci. 2022. DOI: 10.3390/ijms23084089
  63. Kanbara S, Ando K, Kobayashi K, Nakashima H, Machino M, Seki T, Ishizuka S, Ito S, Inoue T, Yamaguchi H, Koshimizu H, Segi N, Tomita H, Hasegawa Y, Imagama S. Metabolic syndrome reduces spinal range of motion: The Yakumo study. J Orthop Sci. 2023. DOI: 10.1016/j.jos.2022.02.008
  64. Segi N, Nakashima H, Shinjo R, Kagami Y, Ando K, Machino M, Ito S, Koshimizu H, Tomita H, Ouchida J, Imagama S. Trabecular Bone Remodeling as a New Indicator of Osteointegration After Posterior Lumbar Interbody Fusion. Global Spine J. 2024. DOI: 10.1177/21925682221090484
  65. Nakano T, Kurimoto S, Ishii H, Iwatsuki K, Yamamoto M, Tatebe M, Hirata H. Mast cell presence in tendon sheaths of trigger fingers: implications on pathogenesis and clinical presentation. J Plast Surg Hand Surg. 2023. DOI: 10.1080/2000656X.2022.2061498
  66. Koshimizu H, Nakashima H, Ohara T, Tauchi R, Kanemura T, Shinjo R, Machino M, Ito S, Ando K, Imagama S. Implant-Related Complications after Spinal Fusion: A Multicenter Study. Global Spine J. 2024. DOI: 10.1177/21925682221094267
  67. Kato D, Takegami Y, Seki T, Nakashima H, Osawa Y, Suzuki K, Yamada H, Hasegawa Y, Imagama S. DNA methylation is associated with muscle loss in community-dwelling older men -the Yakumo study- : a preliminary experimental study. Nagoya J Med Sci. 2022. DOI: 10.18999/nagjms.84.1.60
  68. Kobayashi K, Sato K, Kato F, Kanemura T, Yoshihara H, Sakai Y, Shinjo R, Ohara T, Yagi H, Matsubara Y, Ando K, Nakashima H, Imagama S. Trends in the numbers of spine surgeries and spine surgeons over the past 15 years. Nagoya J Med Sci. 2022. DOI: 10.18999/nagjms.84.1.155
  69. Ouchida J, Nakashima H, Kanemura T, Matsubara Y, Satake K, Muramoto A, Ito K, Tsushima M, Morozumi M, Segi N, Morita Y, Imagama S. Adjacent Segment Degeneration after Short-Segment Lateral Lumbar Interbody Fusion (LLIF). Biomed Res Int. 2022. DOI: 10.1155/2022/5161503
  70. Bando K, Takegami Y, Ando T, Sugino T, Sato T, Fujita T, Imagama S. Early weight bearing and mobilization decrease perioperative complications in patients after ankle fracture; the retrospective multicenter (TRON group) study. J Orthop Sci. 2023. DOI: 10.1016/j.jos.2022.03.002
  71. Suzuki M, Asai S, Sobue Y, Ohashi Y, Koshima H, Okui N, Ishikawa H, Takahashi N, Terabe K, Kishimoto K, Hattori K, Imagama S, Kojima T. Influence of frailty on patient global assessment in rheumatoid arthritis. Geriatr Gerontol Int. 2022. DOI: 10.1111/ggi.14375
  72. Mishima K, Kamiya Y, Matsushita M, Imagama S, Kitoh H. Predictive ability of inflammatory markers and laboratory parameters in Legg-Calvé-Perthes disease: A single-center retrospective comparative study. Medicine (Baltimore). 2022. DOI: 10.1097/MD.0000000000029061
  73. Segi N, Ando K, Nakashima H, Machino M, Imagama S. Intradural Lumbar Disc Herniation From the Lateral Inner Surface of the Dura Without a Penetration Hole: A Case Report. Cureus. 2022. DOI: 10.7759/cureus.22418
  74. Machino M, Nakashima H, Ito K, Ando K, Ito S, Kato F, Imagama S. Cervical disc degeneration is associated with a reduction in mobility: A cross-sectional study of 1211 asymptomatic healthy subjects. J Clin Neurosci. 2022. DOI: 10.1016/j.jocn.2022.03.035
  75. Segi N, Ando K, Nakashima H, Machino M, Ito S, Koshimizu H, Tomita H, Imagama S. Thoracic myelopathy due to ossification of the posterior longitudinal ligament shown on dynamic MR. Surg Neurol Int. 2022. DOI: 10.25259/SNI_14_2022
  76. Sakaguchi T, Ohkawara B, Kishimoto Y, Miyamoto K, Ishizuka S, Hiraiwa H, Ishiguro N, Imagama S, Ohno K. Promethazine Downregulates Wnt/β-Catenin Signaling and Increases the Biomechanical Forces of the Injured Achilles Tendon in the Early Stage of Healing. Am J Sports Med. 2022. DOI: 10.1177/03635465221077116
  77. Kanbara S, Ando K, Kobayashi K, Nakashima H, Machino M, Ito S, Inoue T, Yamaguchi H, Koshimizu H, Segi N, Imagama S. Cicatricial Fibromatosis Causing Cervical Myelopathy Due to Rapid Growth after Removal of Meningioma: A Case Report. Spine Surg Relat Res. 2022. DOI: 10.22603/ssrr.2021-0010
  78. Kagami Y, Nakashima H, Satake K, Ito K, Tanaka S, Segi N, Ouchida J, Morita M, Ando K, Kobayashi K, Machino M, Imagama S, Kanemura T. Assessment of Ureters at Dangerous Locations in Lateral Lumbar Interbody Fusion. Spine Surg Relat Res. 2022. DOI: 10.22603/ssrr.2021-0013
  79. Kuwahara Y, Takegami Y, Tokutake K, Yamada Y, Komaki K, Imagama S. Low body mass index is a risk factor for increased post-operative mortality and poor functional improvement in distal femur fractures among patients aged over 65: A multicentre (TRON) study. J Orthop Sci. 2023. DOI: 10.1016/j.jos.2022.01.014
  80. Machino M, Kawakami N, Ohara T, Saito T, Tauchi R, Imagama S. Factors affecting postoperative pulmonary function deterioration in adolescent idiopathic scoliosis: A prospective study using 3-dimensional image reconstruction by biplanar stereoradiography. J Clin Neurosci. 2022. DOI: 10.1016/j.jocn.2022.02.014
  81. Kuwahara Y, Takegami Y, Tokutake K, Yamada Y, Komaki K, Ichikawa T, Imagama S. How does intraoperative fracture malalignment affect postoperative function and bone healing following distal femoral fracture? : a retrospective multicentre study. Bone Jt Open. 2022. DOI: 10.1302/2633-1462.32.BJO-2021-0191.R1
  82. Ito S, Nakashima H, Ando K, Machino M, Seki T, Ishizuka S, Takegami Y, Wakai K, Hasegawa Y, Imagama S. Nutritional Influences on Locomotive Syndrome. J Clin Med. 2022. DOI: 10.3390/jcm11030610
  83. Mishima K, Kamiya Y, Matsushita M, Imagama S, Kitoh H. Bypass of Epiphyseal Fragmentation Following Early Salter Innominate Osteotomy and Its Clinical Relevance in Legg-Calvé-Perthes Disease. J Pediatr Orthop. 2022. DOI: 10.1097/BPO.0000000000002089
  84. Segi N, Ando K, Nakashima H, Machino M, Ito S, Koshimizu H, Tomita H, Imagama S. Recurrent ossification of the posterior longitudinal ligament in the upper thoracic region 10 years after initial decompression. Surg Neurol Int. 2022. DOI: 10.25259/SNI_1187_2021
  85. Takemoto G, Matsushita M, Okamoto T, Ito T, Matsuura Y, Takashima C, Chen-Yoshikawa TF, Ebi H, Imagama S, Kitoh H, Ohno K, Hosono Y. Meclozine Attenuates the MARK Pathway in Mammalian Chondrocytes and Ameliorates FGF2-Induced Bone Hyperossification in Larval Zebrafish. Front Cell Dev Biol. 2021. DOI: 10.3389/fcell.2021.694018
  86. Ito S, Nakashima H, Matsumoto A, Ando K, Machino M, Segi N, Tomita H, Koshimizu H, Imagama S. Differences in Demographic and Radiographic Characteristics between Patients with Visible and Invisible T1 Slopes on Lateral Cervical Radiographic Images. J Clin Med. 2022. DOI: 10.3390/jcm11020411
  87. Kawamura Y, Hida T, Ohkawara B, Matsushita M, Kobayashi T, Ishizuka S, Hiraiwa H, Tanaka S, Tsushima M, Nakashima H, Ito K, Imagama S, Ito M, Masuda A, Ishiguro N, Ohno K. Meclozine ameliorates skeletal muscle pathology and increases muscle forces in mdx mice. Biochem Biophys Res Commun. 2022. DOI: 10.1016/j.bbrc.2022.01.003
  88. Nakashima H, Imagama S, Yoshii T, Egawa S, Sakai K, Kusano K, Nakagawa Y, Hirai T, Wada K, Katsumi K, Fujii K, Kimura A, Furuya T, Kanchiku T, Nagamoto Y, Oshima Y, Nagoshi N, Ando K, Takahata M, Mori K, Nakajima H, Murata K, Matsunaga S, Kaito T, Yamada K, Kobayashi S, Kato S, Ohba T, Inami S, Fujibayashi S, Katoh H, Kanno H, Li Y, Yatsuya H, Koda M, Kawaguchi Y, Takeshita K, Matsumoto M, Yamazaki M, Okawa A. Comparison of laminoplasty and posterior fusion surgery for cervical ossification of posterior longitudinal ligament. Sci Rep. 2022. DOI: 10.1038/s41598-021-04727-1
  89. Takeda S, Yoneda H, Mitsuya S, Kurahashi S, Hirata H. The ipsilateral distal upper arm can be useful in harvesting the nonvascularized perifascial areolar tissue for hand injuries. J Plast Reconstr Aesthet Surg. 2022. DOI: 10.1016/j.bjps.2021.11.108
  90. Iida H, Sakai Y, Seki T, Watanabe T, Wakao N, Matsui H, Imagama S. Bisphosphonate treatment is associated with decreased mortality rates in patients after osteoporotic vertebral fracture. Osteoporos Int. 2022. DOI: 10.1007/s00198-021-06264-z
  91. Yamada Y, Takegami Y, Tokutake K, Taguchi K, Kuwahara Y, Komaki K, Imagama S. Predictive factors for mortality after distal femoral fractures in the elderly: A retrospective multicenter (TRON group) study. Injury. 2022. DOI: 10.1016/j.injury.2022.01.002
  92. Ando K, Nakashima H, Machino M, Ito S, Segi N, Tomita H, Koshimizu H, Imagama S. Postoperative progression of ligamentum flavum ossification after posterior instrumented surgery for thoracic posterior longitudinal ligament ossification: long-term outcomes during a minimum 10-year follow-up. J Neurosurg Spine. 2022. DOI: 10.3171/2021.10.SPINE211091
  93. Sugimoto R, Tokutake K, Takegami Y, Kanayama Y, Okui N, Sakai T, Kagami Y, Sugimoto T, Imagama S. The Association of Bohler's Angle With Postoperative Pain and Gender for Displaced Intra-Articular Calcaneal Fracture, Multicenter Retrospective Study-TRON Study. J Foot Ankle Surg. 2022. DOI: 10.1053/j.jfas.2021.11.011
  94. Sobue Y, Suzuki M, Ohashi Y, Koshima H, Okui N, Funahashi K, Ishikawa H, Asai S, Terabe K, Yokota Y, Kishimoto K, Takahashi N, Imagama S, Kojima T. Relationship between locomotive syndrome and frailty in rheumatoid arthritis patients by locomotive syndrome stage. Mod Rheumatol. 2022. DOI: 10.1093/mr/roab024
  95. Omichi T, Takegami Y, Tokutake K, Saito Y, Ito O, Ando T, Imagama S. Mortality and functional outcomes of fragility fractures of the pelvis by fracture type with conservative treatment: a retrospective, multicenter TRON study. Eur J Trauma Emerg Surg. 2022. DOI: 10.1007/s00068-021-01839-1
  96. Murayama A, Watanabe K, Ota H, Kurimoto S, Hirata H. Volar plating versus external fixation for unstable dorsal fracture-dislocations of the proximal interphalangeal joint. J Hand Surg Eur Vol. 2022. DOI: 10.1177/17531934211059300
  97. Koike H, Nishida Y, Ito S, Shimoyama Y, Ikuta K, Urakawa H, Sakai T, Shimizu K, Ito K, Imagama S. Diffusion-Weighted Magnetic Resonance Imaging Improves the Accuracy of Differentiation of Benign from Malignant Peripheral Nerve Sheath Tumors. World Neurosurg. 2022. DOI: 10.1016/j.wneu.2021.09.130
  98. Ishii H, Kurimoto S, Tatebe M, Yamamoto M, Iwatsuki K, Hirata H. Postoperative peripheral neuropathy considered to be induced by surgical stress. J Orthop Sci. 2022. DOI: 10.1016/j.jos.2021.08.015
  99. Sugimoto T, Tokutake K, Takegami Y, Okui N, Kanayama Y, Inoue H, Sugimoto R, Kagami Y, Imagama S. Plate fixation through the lateral extensile approach versus cannulated screw fixation through the sinus tarsi approach for calcaneal fracture: a multicenter, propensity score-matched TRON study. Eur J Orthop Surg Traumatol. 2022. DOI: 10.1007/s00590-021-03115-9
  100. Kobayashi K, Imagama S, Ando K, Yoshida G, Ando M, Kawabata S, Yamada K, Kanchiku T, Fujiwara Y, Taniguchi S, Iwasaki H, Shigematsu H, Tadokoro N, Takahashi M, Wada K, Yamamoto N, Funaba M, Yasuda A, Ushirozako H, Hashimoto J, Morito S, Takatani T, Tani T, Matsuyama Y. Characteristics of Tc-MEP Waveforms for Different Locations of Intradural Extramedullary Tumors: A Prospective Multicenter Study of the Monitoring Committee of the Japanese Society for Spine Surgery and Related Research. Spine (Phila Pa 1976). 2022. DOI: 10.1097/BRS.0000000000004112
  101. Machino M, Ando K, Kobayashi K, Nakashima H, Ito S, Morozumi M, Kanbara S, Segi N, Tomita H, Koshimizu H, Seki T, Ishizuka S, Takegami Y, Hasegawa Y, Imagama S. Associations Between Neck and Shoulder Pain and Neuropathic Pain in a Middle-aged Community-living Population. Spine (Phila Pa 1976). 2022. DOI: 10.1097/BRS.0000000000004207
  102. Saito Y, Tokutake K, Takegami Y, Yoshida M, Omichi T, Imagama S. Does surgical treatment for unstable fragility fracture of the pelvis promote early mobilization and improve survival rate and postoperative clinical function? Eur J Trauma Emerg Surg. 2022. DOI: 10.1007/s00068-021-01729-6
  103. Kawashima I, Sugaya H, Takahashi N, Matsuki K, Tokai M, Ishizuka S, Hiraiwa H, Imagama S. Biceps tenotomy versus soft-tissue tenodesis in females aged 60 years and older with rotator cuff tears. J Orthop Sci. 2022. DOI: 10.1016/j.jos.2021.04.012
  104. Nakashima H, Yoneda M, Kanemura T, Satake K, Ito K, Ouchida J, Ando K, Kobayashi K, Imagama S. Conservative treatment of spondylolysis involving exercise initiated early and sports activities resumed with a lumbar-sacral brace. J Orthop Sci. 2022. DOI: 10.1016/j.jos.2021.01.013
  105. Takegami Y, Seki T, Osawa Y, Makida K, Ochiai S, Nakashima H, Fujii R, Yamada H, Suzuki K, Hasegawa Y, Imagama S. A preliminary examination of the association between locomotive syndrome and circulating miRNA-199 in community-dwelling people: The Yakumo study. J Orthop Sci. 2022. DOI: 10.1016/j.jos.2021.02.003
  106. Kawasaki N, Takegami Y, Sakai R, Todoroki K, Uemi R, Imagama S. Prediction of delayed union of tibial shaft fracture treated with intramedullary nailing: multicenter-study analysis and literature review -the TRON study. Eur J Orthop Surg Traumatol. 2022. DOI: 10.1007/s00590-021-02939-9
  107. Kawashima I, Kawai R, Tsukahara T, Hiraiwa H, Ishizuka S, Kusaka Y, Imagama S. Outcomes of pediatric anterior cruciate ligament reconstructions in patients with and without bucket handle meniscus repairs. J Pediatr Orthop B. 2022. DOI: 10.1097/BPB.0000000000000857
  108. Tanaka S, Ando K, Kobayashi K, Nakashima H, Seki T, Ishizuka S, Machino M, Ito S, Kanbara S, Kanemura T, Hasegawa Y, Imagama S. Differences in the prevalence of locomotive syndrome and osteoporosis in Japanese urban and rural regions: The Kashiwara and Yakumo studies. Mod Rheumatol. 2022. DOI: 10.1080/14397595.2021.1899890
  109. Takemoto G, Seki T, Takegami Y, Osawa Y, Makida K, Ochiai S, Ishizuka S, Suzuki K, Hasegawa Y, Imagama S. The development of knee osteoarthritis and serum carotenoid levels among community-dwelling people in Japan. Mod Rheumatol. 2022. DOI: 10.1080/14397595.2021.1900030
  110. Nakashima H, Kanemura T, Satake K, Ito K, Tanaka S, Segi N, Ouchida J, Kagami Y, Ando K, Kobayashi K, Imagama S. Sacroiliac Joint Degeneration After Lumbopelvic Fixation. Global Spine J. 2022. DOI: 10.1177/2192568220978235
  111. Tatebe M, Morita A, Kurahashi T, Hirata H. Difference in Carpal Alignment between Scapholunate Dissociation and Kienbock Disease: A Retrospective Study. J Hand Microsurg. 2022. DOI: 10.1055/s-0040-1717829
  112. Ito S, Sakai Y, Harada A, Ando K, Kobayashi K, Machino M, Ota K, Morozumi M, Tanaka S, Kanbara S, Ishiguro N, Imagama S. Myelopathy caused by intrathecal remnants of oil-based contrast medium. J Orthop Sci. 2022. DOI: 10.1016/j.jos.2019.12.016

Research Keywords

Bone regenerative medicine, Achondroplasia, bone lengthening, Hyperthermia, Desmoid-type fibromatosis, Rheumatoid arthritis, Biologic agent, Tsurumai Biologics Communication Registry, Tendinopathy, Wnt-β-catenin signaling, Eccentric rotational acetabular osteotomy, pre-operative predictive score, Yakumo study

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