Laboratories

Endocrinology and Diabetes

KEYWORDS

  • AVP-D
  • obesity
  • Regenerative medicine
  • irAE
  • Arginine vasopressin (AVP)
  • Neurohypophysial diabetes insipidus, Hyponatremia
  • Lymphocytic infundibulo-neurohypophysitis (LINH)
  • Anti-rabphilin-3A antibody
  • ES cells
  • iPS cells
  • Exocytosis
  • Osmotic demyelination syndrome (ODS)
  • Energy balance
  • Type 1 diabetes
  • Type 2 diabetes
  • GIP
  • GLP-1
  • Insulin
  • Glucagon
  • Glucose
  • Fructose
  • KATP channel
  • Endoplasmic reticulum stress  

HEAD

ARIMA Hiroshi

Professor

Researchers

LAB MEMBER

Faculty Position Researchers
BANNO Ryoichi Lecturer Researchers
SUGA Hidetaka Lecturer Researchers
GOTO Motomitsu Lecturer of Hospital
IWAMA Shintaro Designated Lecturer Researchers
SEINO Yusuke Assistant Professor
TAKAGI Hiroshi Assistant Professor
MORISHITA Yoshiaki Designated Assistant Professor
ITO Yoshihiro Designated Assistant Professor
TSUNEKAWA Taku Assistant Professor of Hospital
ONOUE Takeshi Assistant Professor of Hospital Researchers

CONTACT

Email iga-ryu◎t.mail.nagoya-u.ac.jp (Please send a message after replacing "◎" mark with "@" mark. )
HP Private Page

OUTLINE

 The Department of Endocrinology and Diabetes was established in 2003. Under the leadership of Professor Arima, we provide fine care for patients with metabolic diseases and hormonal disorders such as pituitary dysfunction and thyroid diseases. We have also been performing basic and clinical research on endocrinology and metabolic diseases.

RESEARCH PROJECTS

1. Basic research on arginine vasopressin

Arginine vasopressin (AVP), an antidiuretic hormone, is synthesized in the hypothalamus and stored in the posterior pituitary. Increases in plasma osmolality and decreases in effective circulating volume stimulate its secretion into the systemic circulation. Dysregulation of AVP secretion can lead to AVP deficiency and the syndrome of inappropriate antidiuretic hormone secretion (SIADH). “Masked AVP deficiency” is a condition in which polyuria becomes clinically inapparent when AVP deficiency coexists with adrenal insufficiency; however, the precise underlying mechanisms remain unclear. We are currently investigating the effects of glucocorticoids on AVP secretion to elucidate the pathophysiology of masked AVP deficiency. In addition, we are analyzing a mouse model of familial central diabetes insipidus, a hereditary form of the disease, to further clarify its pathogenesis.

2. Regenerative Medicine for the Hypothalamus and Adenohypophysis

Once the hypothalamus or pituitary loses its function, it rarely recovers naturally. In our department, we are advancing technological development to realize regenerative medicine for hypothalamic neurons and anterior pituitary cells. Using embryonic stem (ES) cells and induced pluripotent stem (iPS) cells as starting materials, we generate hypothalamic and pituitary tissues by three-dimensionally recapitulating fetal development of the hypothalamic–pituitary system in vitro.
To enable clinical application through transplantation therapy, we are developing manufacturing methods, transplantation techniques, and quality control systems, and are conducting safety and efficacy studies. In addition, by applying these technologies, we are pursuing a wide range of research goals, including pathophysiological analysis of genetic diseases using disease-specific iPS cells, modeling of human fetal development, reconstruction of the life course including aging, generation of tissue stem cells of the hypothalamus and pituitary, and reproduction of broad hypothalamic functions such as circadian rhythms.

3. Clinical research on the diagnosis and treatment of hyponatremia using AI

Hyponatremia is commonly classified into three categories based on effective circulating volume status: increased, near-normal, and decreased. Because management differs across these categories, accurate differentiation is essential. In routine clinical practice, however, appropriate assessment of effective circulating volume is often challenging, and clinicians frequently struggle with the differential diagnosis of hyponatremia. Our laboratory conducts real-world surveys on hyponatremia and its management, and by applying AI-based analytical approaches, we aim to establish a novel method for differentiating hyponatremia. Severe hyponatremia can cause serious neurological symptoms such as impaired consciousness and seizures, necessitating prompt treatment. At the same time, overly rapid correction of serum sodium within a short period is a known risk factor for osmotic demyelination syndrome. Thus, the treatment of severe hyponatremia involves a clinical dilemma: serum sodium must be corrected urgently, yet excessive increases must be avoided to prevent osmotic demyelination syndrome. Our goal is to develop a safer treatment protocol for hyponatremia by building a machine-learning–based system to predict treatment responses in patients with severe hyponatremia.

4. Pathophysiological Research on Obesity and Diabetes

Energy balance is regulated by the brain (central nervous system). Obesity, a major cause of lifestyle-related diseases, has already reached pandemic levels worldwide; however, effective medical treatments have yet to be fully established. Therefore, elucidating the mechanisms underlying its development and establishing new therapeutic strategies are strongly needed. Using various genetically engineered mouse models, we investigate stress-induced overeating, high-fat diet–induced obesity, and abnormalities in glucose and energy metabolism caused by combined high-fat and high-salt intake, as well as central mechanisms of brain-mediated regulation of glucose metabolism.

5. Basic and Clinical Research on Endocrine Adverse Events Induced by Immune Checkpoint Inhibitors

Immune checkpoint inhibitors (ICIs) have become widely used for the treatment of advanced malignancies. However, the development of immune related adverse events (irAEs), which are thought to involve autoimmune mechanisms, has emerged as a significant clinical challenge. irAEs can occur in various organs, including the lungs, gastrointestinal tract, skin, and endocrine organs. In endocrine irAEs, dysfunction of the pituitary, thyroid, adrenal cortex, pancreatic β cells, and parathyroid glands has been reported. Although appropriate management of irAEs is essential for the expanding use of ICI based cancer immunotherapy, the clinical characteristics and underlying mechanisms of endocrine irAEs remain insufficiently understood. To address these issues, we are currently conducting a prospective clinical study at Nagoya University Hospital that includes all patients receiving ICIs, aiming to clarify the features of endocrine irAEs. Recently, we characterized thyroid dysfunction induced by nivolumab, an anti PD 1 antibody, and identified antithyroid antibody evaluation as a potential pre treatment marker for identifying patients at high risk of developing thyroid dysfunction. In addition, we have newly developed mouse models of hypophysitis and thyroiditis induced by anti CTLA 4 and anti PD 1 antibodies to investigate the mechanisms of disease onset.
We believe that both basic and clinical research on irAEs will not only contribute to the development of safer cancer immunotherapies but also provide insights into the pathogenesis of autoimmune endocrine disorders of previously unknown etiology.

6. Clinical Research Focused on Diabetes and Obesity

In collaboration with medical institutions, we conduct clinical observational studies on type 1 diabetes using a dedicated database to clarify its real-world characteristics. We also perform interventional studies in type 2 diabetes to improve lifestyle behaviors by utilizing continuous glucose monitoring (CGM) and digital technologies such as IoT, AI, and mobile applications. In addition, we are conducting research on obesity aimed at achieving sustainable weight loss by evaluating individual basal metabolism using breath gas analysis.

BIBLIOGRAPHY

2025
  1. Handa T, Onoue T, Maeda R, Mizutani K, Suzuki K, Kobayashi T, Miyata T, Sugiyama M, Hagiwara D, Iwama S, Suga H, Banno R, Arima H. Guidance on Energy Intake Based on Resting Energy Expenditure and Physical Activity: Effective for Reducing Body Weight in Patients with Obesity. Nutrients 2025;17(2):202
  2. Hirose T, Kuno M, Sasaki T, Taki K, Ito Y, Miyata T, Kobayashi T, Sugiyama M, Onoue T, Hagiwara D, Iwama S, Suga H, Banno R, Arima H. Dapagliflozin increased pancreatic beta cell proliferation and insulinogenic index in mice fed a high-fat and high-sodium chloride diet. Biochemical and Biophysical Research Communications. 2025;749:151364
  3. Tsumura T, Hagiwara D, Naito S, Kondo Y, Kawaguchi Y, Miyata T, Kobayashi T, Sugiyama M, Onoue T, Iwama S, Suga H, Banno R, Arima H. Compensatory mechanisms underlying arginine vasopressin regulation in transient polyuria during pregnancy Peptides 2025;184:171352
  4. Maeda R, Onoue T, Mizutani K, Suzuki K, Handa T, Kobayashi T, Iwama S, Miyata T, Sugiyama M, Hagiwara D, Suga H, Kinoshita F, Arima H. Continuous glucose monitoring with low-glucose alerts in insulin-treated drivers with diabetes: A randomized crossover study. Diabetes Res Clin Pract 2025;222:112074
2024
  1. Kobayashi T, Iwama S, Arima H. Clinical characteristics and potential biomarkers of thyroid and pituitary immune-related adverse events. Endocr J. 2024 Jan 29;71(1):23-29
  2. Miwata T, Suga H, Mitsumoto K, Zhang J, Hamada Y, Sakakibara M, Soen M, Ozaki H, Asano T, Miyata T, Kawaguchi　Y, Yasuda Y, Kobayashi T, Sugiyama M, Onoue T, Hagiwara D, Iwama S, Oyadomari S, Arima H. Simplified drug efficacy evaluation system for vasopressin neurodegenerative disease using mouse disease-specific induced pluripotent stem cells. Peptides 2024; 173: 171151
  3. Handa T, Onoue T, Kobayashi T, Maeda R, Mizutani K, Yamagami A, Kinoshita T, Yasuda Y, Iwama S, Miyata T, Sugiyama M, Takagi H, Hagiwara D, Suga H, Banno R, Azuma Y, Kasai T, Yoshioka S, Kuwatsuka Y, Arima H. Effects of Digitization of Self-Monitoring of Blood Glucose Records Using a Mobile App and the Cloud System on Outpatient Management of Diabetes: Single-Armed Prospective Study. JMIR Diabetes 2024; 19(9): e48019
  4. Okuji T, Iwama S, Kobayashi T, Yasuda Y, Ito M, Yamagami A, Ando M, Hase T, Shibata H, Hatta T, Zhou X, Onoue T, Kawaguchi Y, Miyata T, Sugiyama M, Hagiwara D, Suga H, Banno R, Ando Y, Hashimoto N, Arima H. Thyroid autoantibodies at baseline predict longer survival in non-small cell lung cancer patients treated with anti-programmed cell death-1 blockade: a prospective study Nagoya J Med Sci. 2024;86(3):452-463
  5. Yamagami A, Iwama S, Kobayashi T, Zhou X, Yasuda Y, Okuji T, Ito M, Izuchi T, Ando M, Onoue T, Miyata T, Sugiyama M, Hagiwara D, Suga H, Banno R, Arima H. Changes in TgAb and TPOAb titers are greater in thyrotoxicosis than isolated hypothyroidism induced by PD-1 blockade. Endocr J.2024;71(5):515-526
  6. Kobayashi T, Iwama S, Yamagami A, Izuchi T, Suzuki K, Otake K, Yasuda Y, Ando M, Onoue T, Miyata T, Sugiyama M, Hagiwara D, Suga H, Banno R, Hase T, Nishio N, Mori S, Shimokata T, Sano T, Niimi K, Yoshikawa N, Akamatsu S, Ando Y, Akiyama M, Sone M, Ishii M, Arima H. Combined use of tyrosine kinase inhibitors with PD-(L)1 blockade increased the risk of thyroid dysfunction in PD-(L)1 blockade: a prospective study Cancer Immunol Immunother. 2024;73(8):146
  7. Sasaki T, Sugiyama M, Kuno M, Miyata T, Kobayashi T, Yasuda Y, Onoue T, Takagi H, Hagiwara D, Iwama S, Suga H, Banno R, Arima H. Voluntary exercise suppresses inflammation and improves insulin resistance in the arcuate nucleus and ventral tegmental area in mice on a high-fat diet. Physiol Behav. 2024;287:114703
  8. Asano T, Suga H, Niioka H, Yukawa H, Sakakibara M, Taga S, Soen M, Miwata T, Sasaki H, Seki T, Hasegawa S, Murakami S, Abe M, Yasuda Y, Miyata T, Kobayashi T, Sugiyama M, Onoue T, Hagiwara D, Iwama S, Baba Y, Arima H. A deep-learning approach to predict differentiation outcomes in hypothalamic-pituitary organoids Communications Biology 2024;7:1468
  9. Suzuki K, Kobayashi T, Izuchi T, Otake K, Ando M, Handa T, Miyata T, Sugiyama M, Onoue T, Hagiwara D, Suga H, Banno R, Hase T, Inoue M, Ishii M, Arima H, Iwama S. Development of pituitary dysfunction and destructive thyroiditis is associated with better survival in non-small cell lung cancer patients treated with programmed cell death-1 inhibitors: a prospective study with immortal time bias correction Front Endocrinol.2024;15:1490042
  10. Kobayashi T, Iwama S, Suzuki K, Arima H. Hyperthyroidism Due to Functioning Metastatic Bone Lesions of Follicular Thyroid Carcinoma Treated With Lenvatinib. JCEM Case reports 2024;2(7):139
  11. Kinoshita T, Oyama S, Hagiwara D, Azuma Y, Arima H. A machine learning approach for predicting treatment response of hyponatremia Endocr J. 2024;71(4):345-355
  12. Hayase A, Onoue T, Nishida K, Nakata Y, Hayashi F, Marutani M, Sakane N, Okamura T, Matsuzaki K, Kawamura T, Tsushita K. Influence of previous health guidance history: impact and limitations of a single health guidance session. Environ Occup Health Pract. 2024;6(1):2024-0011-OA
  13. Onoue T, Asada Y, Imafuku R, Kou S, Takami H, Takahashi Y, Nomura O, Saiki T. Developing competencies relating to information science and technology in Japanese undergraduate medical education. Med Teach. 2024;46(sup 1):S31-S37
2023
  1. Kobayashi T, Iwata T, Handa K, Arima H. Pyogenic spondylitis due to Streptococcus agalactiae with paraspinal abscess and vertebral destruction in a diabetic patient: time course of imagings. Endocrinol Diabetes Metab Case Rep. 2023(1): 22-0305
  2. Handa T, Onoue T, Kobayashi T, Wada E, Hayase A, Kinoshita T, Yamagami A, Yasuda Y, Iwama S, Kawaguchi Y, Miyata T, Sugiyama M, Takagi H, Hagiwara D, Suga H, Banno R, Goto M, Arima H. Resting energy expenditure depends on energy intake during weight loss in people with obesity: a retrospective cohort study. Arch Endocrinol Metab. 2023; 67(2): 233-241
  3. Miwata T, Suga H, Kawaguchi Y, Sakakibara M, Kano M, Taga S, Soen M, Ozaki H, Asano T, Sasaki H, Miyata T, Yasuda Y, Kobayashi T, Sugiyama M, Onoue T, Takagi H, Hagiwara D, Iwama S, Arima H. Generation of hypothalamic neural stem cell-like cells in vitro from human pluripotent stem cells. Stem Cell Reports 2023; 18(4): 869-883
  4. Ito Y, Sun R, Yaginuma H, Taki K, Mizoguchi A, Kobayashi T, Sugiyama M, Onoue T, Tsunekawa T, Takagi H, Hagiwara D, Iwama S, Suga H, Konishi H, Kiyama H, Arima H, Banno R. Protein Tyrosine Phosphatase 1B Deficiency Improves Glucose Homeostasis in Type 1 Diabetes Treated With Leptin. Diabetes 2023; 71(9): 1902-1914
  5. Ito M, Iwama S, Sugiyama D, Yasuda Y, Okuji T, Kobayashi T, Zhou X, Yamagami A, Onoue T, Miyata T, Sugiyama M, Hagiwara D, Suga H, Banno R, Nishikawa H, Arima H. Anti-tumor effects of anti-programmed cell death-1 antibody treatment are attenuated in streptozotocin-induced diabetic mice. Sci Rep. 2023; 13(1): 5939
  6. Zhou X, Iwama S, Kobayashi T, Ando M, Arima H. The risk of thyroid dysfunction in PD-1 blockade is stratified by the pattern of TgAb and TPOAb positivity at baseline. J Clin Endocrinol Metab. 2023;108(10):e1056-e1062
  7. Taga S, Suga H, Nakano T, Kuwahara A, Inoshita N, Kodani Y, Nagasaki H, Sato Y, Tsumura Y, Sakakibara M, Soen M, Miwata T, Ozaki H, Kano M, Watari K, Ikeda A, Yamanaka M, Takahashi Y, Kitamoto S, Kawaguchi Y, Miyata T, Kobayashi T, Sugiyama M, Onoue T, Yasuda Y, Hagiwara D, Iwama S, Tomigahara Y, Kimura T, Arima H. Generation and purification of ACTH-secreting hPSC-derived pituitary cells for effective transplantation. Stem Cell Reports. 2023; 18: 1-15
  8. Hayase A, Onoue T, Kobayashi T, Wada E, Handa T, Kinoshita T, Yamagami A, Yasuda Y, Iwama S, Kawaguchi Y, Miyata T, Sugiyama M, Takagi H, Hagiwara D, Suga H, Banno R, Kuwatsuka Y, Ando M, Goto M, Arima H. Improved glycemic control after the use of flash glucose monitoring accompanied by improved treatment satisfaction in patients with non-insulin-treated type 2 diabetes: A post-hoc analysis of a randomized controlled trial. Prim Care Diabetes 2023; 6: 575-580
  9. Hagiwara D, Azuma Y, Kawaguchi Y, Miyata T, Arima H. Response to endoplasmic reticulum stress in arginine vasopressin neurons. Endocr J 2023; 70(6): 567-572
  10. Hagiwara D, Matsukawa M, Tasaki J, Nakamura Y, Arima H. A retrospective study on tolvaptan prescription in clinical practice in patients with syndrome of inappropriate secretion of antidiuretic hormone (SIADH) using the Japanese claims database. Endocr J 2023; 70(12): 1195-1205
2022
  1. Iwama S, Kobayashi T, Yasuda Y, Okuji T, Ito M, Ando M, Zhou X, Yamagami A, Onoue T, Kawaguchi Y, Miyata T, Sugiyama M, Takagi H, Hagiwara D, Suga H, Banno R, Hase T, Morise M, Wakahara K, Yokota K, Kato M, Nishio N, Tanaka C, Miyata K, Ogura A, Ito T, Sawada T, Shimokata T, Niimi K, Ohka F, Ishigami M, Gotoh M, Hashimoto N, Saito R, Kiyoi H, Kajiyama H, Ando Y, Hibi H, Sone M, Akiyama M, Kodera Y, Arima H. Increased Risk of Thyroid Dysfunction by PD-1 and CTLA-4 Blockade in Patients Without Thyroid Autoantibodies at Baseline. J Clin Endocrinol Metab. 2022; 107(4): e1620-e1630.
  2. Iwama S, Kobayashi T, Yasuda Y, Arima H. Immune checkpoint inhibitor-related thyroid dysfunction. Best Pract Res Clin Endocrinol Metab. 2022; 36(3): 101660.
  3. Kobayashi T, Iwama S, Yamagami A, Yasuda Y, Okuji T, Ito M, Zhou X, Ando M, Onoue T, Miyata T, Sugiyama M, Hagiwara D, Suga H, Banno R, Hase T, Morise M, Ito T, Kikumori T, Inoue M, Ando Y, Masuda N, Kawashima H, Hashimoto N, Arima H. Elevated TSH Level, TgAb, and Prior Use of Ramucirumab or TKIs as Risk Factors for Thyroid Dysfunction in PD-L1 Blockade. J Clin Endocrinol Metab. 2022; 107(10): e4115-e4123
  4. Ozaki H, Suga H*, Sakakibara M, Soen M, Miyake N, Miwata T, Taga S, Nagai T, Kano M, Mitsumoto K, Miyata T, Kobayashi T, Sugiyama M, Onoue T, Takagi H, Hagiwara D, Iwama S, Banno R, Iguchi G, Takahashi Y, Muguruma K, Inoue H, Arima H. Differentiation of human induced pluripotent stem cells into hypothalamic vasopressin neurons with minimal exogenous signals and partial conversion to the naive state. Scientific Reports. 2022; 12: 17381
  5. Sun R, Sugiyama M, Wang S, Kuno M, Sasaki T, Hirose T, Miyata T, Kobayashi T, Tsunekawa T, Onoue T, Yasuda Y, Takagi H, Hagiwara D, Iwama S, Suga H, Arima H. Inflammation in VTA Caused by HFD Induces Activation of Dopaminergic Neurons Accompanied by Binge-like Eating. Nutrients 2022; 16: 3835
2021
  1. Iwama S, Kobayashi T, Arima H. Clinical Characteristics, Management, and Potential Biomarkers of Endocrine Dysfunction Induced by Immune Checkpoint Inhibitors. Endocrinol Metab (Seoul). 2021;36(2):312-321.
  2. Yasuda Y, Iwama S, Sugiyama D, Okuji T, Kobayashi T, Ito M, Okada N, Enomoto A, Ito S, Yan Y, Sugiyama M, Onoue T, Tsunekawa T, Ito Y, Takagi H, Hagiwara D, Goto M, Suga H, Banno R, Takahashi M, Nishikawa H, Arima H. CD4+ T cells are essential for the development of destructive thyroiditis induced by anti-PD-1 antibody in thyroglobulin-immunized mice. Sci Transl Med. 2021;13(593):eabb7495.
  3. Kobayashi T, Iwama S, Sugiyama D, Yasuda Y, Okuji T, Ito M, Ito S, Sugiyama M, Onoue T, Takagi H, Hagiwara D, Ito Y, Suga H, Banno R, Nishikawa H, Arima H. Anti-pituitary antibodies and susceptible human leukocyte antigen alleles as predictive biomarkers for pituitary dysfunction induced by immune checkpoint inhibitors. J Immunother Cancer. 2021;9(5):e002493
  4. Kawabata T, Suga H, Takeuchi K, Nagata Y, Sakakibara M, Ushida K, Ozone C, Enomoto A, Kawamoto I, Itagaki I, Tsuchiya H, Arima H, Wakabayashi T. A new primate model of hypophyseal dysfunction, Scientific Reports 2021;11(1):10729
  5. Yaginuma H, Banno R, Sun R, Taki K, Mizoguchi A, Kobayashi T, Sugiyama M, Tsunekawa T, Onoue T, Takagi H, Hagiwara D, Ito Y, Iwama S, Suga H, Arima H. Peripheral combination treatment of leptin and an SGLT2 inhibitor improved glucose metabolism in insulin-dependent diabetes mellitus mice. J Pharmacol Sci. 2021;147(4):340-347
  6. Mizoguchi A, Banno R, Sun R, Yaginuma H, Taki K, Kobayashi T, Sugiyama M, Tsunekawa T, Onoue T, Takagi H, Hagiwara D, Ito Y, Iwama S, Suga H, Nagai T, Yamada K, Arima H. Glucocorticoid receptor signaling in ventral tegmental area neurons increases the rewarding value of a high-fat diet in mice.Sci Rep. 2021;11(1):12873
  7. Sun R, Tsunekawa T, Hirose T, Yaginuma H, Taki K, Mizoguchi A, Miyata T, Kobayashi T, Sugiyama M, Onoue T, Takagi H, Hagiwara D, Ito Y, Iwama S, Suga H, Banno R, Bettler B, Arima H. GABAB receptor signaling in the caudate putamen is involved in binge-like consumption during a high fat diet in mice. Sci Rep. 2021;11(1):19296
  8. Wada E, Onoue T, Kinoshita T, Hayase A, Handa T, Ito M, Furukawa M, Okuji T, Kobayashi T, Iwama S, Sugiyama M, Takagi H, Hagiwara D, Suga H, Banno R, Goto M, Arima H. Adult-onset autoimmune diabetes identified by glutamic acid decarboxylase autoantibodies: a retrospective cohort study. Diabetologia. 2021;64(10):2183-2192
  9. Furukawa M, Onoue T, Kato K, Wada T, Shinohara Y, Kinoshita F, Goto M, Arima H, Tsushita K. Prediabetes is associated with proteinuria development but not with glomerular filtration rate decline: A longitudinal observational study. Diabet Med. 2021;38(8):e14607
  10. Mizoguchi A, Banno R, Sun R, Yaginuma H, Taki K, Kobayashi T, Sugiyama M, Tsunekawa T, Onoue T, Takagi H, Hagiwara D, Ito Y, Iwama S, Suga H, Arima H. High-fat Feeding Causes Inflammation and Insulin Resistance in the Ventral Tegmental Area in Mice. neuroscience. 2021; 461: 72-79.
  11. Ozaki H,. Suga H., Arima H. Hypothalamic-pituitary organoid generation through the recapitulation of organogenesis. Development, growth & differentiation. 2021; 63(2): 154-165.
  12. Hagiwara D, Tochiya M, Azuma Y, Tsumura T, Hodai Y, Kawaguchi Y, Miyata T, Kobayashi T, Sugiyama M, Onoue T, Takagi H, Ito Y, Iwama S, Suga H, Banno R, Arima H. Arginine vasopressin-Venus reporter mice as a tool for studying magnocellular arginine vasopressin neurons. Peptides. 2021; 139: 170517.
  13. Taki K, Takagi H, Hirose T, Sun R, Yaginuma H, Mizoguchi A, Kobayashi T, Sugiyama M, Tsunekawa T, Onoue T, Hagiwara D, Ito Y, Iwama S, Suga H, Banno R, Sakano D, Kume S, Arima H. Dietary sodium chloride attenuates increased β-cell mass to cause glucose intolerance in mice under a high-fat diet. PLoS One. 2021; 16(3): e0248065.
2020
  1. Sugiyama M, Banno R, Yaginuma H, Taki K, Mizoguchi A, Tsunekawa T, Onoue T, Takagi H, Ito Y, Iwama S, Goto M, Suga H, Komine O, Yamanaka K, Arima H. Hypothalamic glial cells isolated by MACS reveal that microglia and astrocytes induce hypothalamic inflammation via different processes under high-fat diet conditions. neurochemistry international. 2020;136:104733.
  2. Yoshida S, Okura H, Suga H, Nishitomi T, Sakurai A, Arima H, Matsuyama A. Generation of Three Induced Pluripotent Stem Cell (iPSC) Lines From a Multiple Endocrine Neoplasia Type 1 (MEN1) Patient and Three iPSC Lines From an Unaffected Relative of the Patient. Stem Cell Res. 2020;46:101846.
  3. Kobayashi T, Iwama S, Yasuda Y, Okada N, Okuji T, Ito M, Onoue T, Goto M, Sugiyama M, Tsunekawa T, Takagi H, Hagiwara D, Ito Y, Suga H, Banno R, Yokota K, Hase T, Morise M, Hashimoto N, Ando M, Fujimoto Y, Hibi H, Sone M, Ando Y, Akiyama M, Hasegawa Y, Arima H.Pituitary dysfunction induced by immune checkpoint inhibitors is associated with better overall survival in both malignant melanoma and non-small cell lung carcinoma: a prospective study. J Immunother Cancer. 2020;8(2):e000779.
  4. Yoshida S, Okura H, Suga H, Soen M, Kawaguchi Y, Kurimoto J, Miyata T, Takagi H, Arima H, Fujikawa T, Otsuka F, Matsuyama A. Generation of four induced pluripotent stem cell lines (FHUi003-A, FHUi003-B, FHUi004-A, and FHUi004-B) from two affected individuals of a familial neurophypophyseal diabetes insipidus family. Stem Cell Res. 2020;48:101960.
  5. Miyata T, Hagiwara D, Hodai Y, Miwata T, Kawaguchi Y, Kurimoto J, Ozaki H, Mitsumoto K, Takagi H, Suga H, Kobayashi T, Sugiyama M, Onoue T, Ito Y, Iwama S, Banno R, Matsumoto M, Kawakami N, Ohno N, Sakamoto H, Arima H. Degradation of mutant protein aggregates within the endoplasmic reticulum of vasopressin neurons. iScience. 2020;23(10);101648.
  6. Iwama S, Arima H. Anti-pituitary antibodies as a marker of autoimmunity in pituitary glands. Endocr J. 2020;67(11):1077-1083.
  7. Wada E, Onoue T, Kobayashi T, Handa T, Hayase A, Ito M, Furukawa M, Okuji T, Okada N, Iwama S, Sugiyama M, Tsunekawa T, Takagi H, Hagiwara D, Ito Y, Suga H, Banno R, Kuwatsuka Y, Ando M, Goto M, Arima H. Flash glucose monitoring helps achieve better glycemic control than conventional self-monitoring of blood glucose in non-insulin-treated type 2 diabetes: a randomized controlled trial. BMJ Open Diabetes Res Care. 2020;8(1):e001115.
  8. Kawaguchi Y, Hagiwara D, Miyata T, Hodai Y, Kurimoto J, Takagi H, Suga H, Kobayashi T, Sugiyama M, Onoue T, Ito Y, Iwama S, Banno R, Grinevich V, Arima H.Endoplasmic reticulum chaperone BiP/GRP78 knockdown leads to autophagy and cell death of arginine vasopressin neurons in mice. Sci Rep. 2020;10(1):19730.
  9. Okada N, Iwama S, Okuji T, Kobayashi T, Yasuda Y, Wada E, Onoue T, Goto M, Sugiyama M, Tsunekawa T, Takagi H, Hagiwara D, Ito Y, Suga H, Banno R, Hase T, Morise M, Kanda M, Yokota K, Hashimoto N, Ando M, Fujimoto Y, Nagino M, Kodera Y, Fujishiro M, Hibi H, Sone M, Kiyoi H, Gotoh M, Ando Y, Akiyama M, Hasegawa Y, Arima H. Anti-thyroid antibodies and thyroid echo pattern at baseline as risk factors for thyroid dysfunction induced by anti-programmed cell death-1 antibodies: a prospective study. Br J Cancer. 2020; 122(6): 771-777.
2019
  1. Yasuda Y, Iwama S, Arima H. Severe hypocalcemia following denosumab treatment in a patient with secondary osteoporosis associated with primary sclerosing cholangitis. Endocrine journal. 2019;66(3):271-275.
  2. Suga H. Application of pluripotent stem cells for treatment of human neuroendocrine disorders. Cell and tissue research. 2019;375(1):267-278.
  3. Murase M, Seino Y, Maekawa R, et al. Functional adenosine triphosphate-sensitive potassium channel is required in high-carbohydrate diet-induced increase in beta-cell mass. Journal of diabetes investigation. 2019;10(2):238-250.
  4. Kobayashi T, Tsushita K, Nomura E, et al. Automated Feedback Messages With Shichifukujin Characters Using IoT System-Improved Glycemic Control in People With Diabetes: A Prospective, Multicenter Randomized Controlled Trial. Journal of diabetes science and technology. 2019;13(4):796-798.
  5. Hagiwara D, Grinevich V, Arima H. A novel mechanism of autophagy-associated cell death of vasopressin neurons in familial neurohypophysial diabetes insipidus. Cell and tissue research. 2019;375(1):259-266.
  6. Arima H, Iwama S, Inaba H, et al. Management of immune-related adverse events in endocrine organs induced by immune checkpoint inhibitors: clinical guidelines of the Japan Endocrine Society. Endocrine journal. 2019;66(7):581-586.
  7. Kano M, Suga H, Ishihara T, et al. Tanycyte-Like Cells Derived From Mouse Embryonic Stem Culture Show Hypothalamic Neural Stem/Progenitor Cell Functions. Endocrinology. 2019;160(7):1701-1718.
  8. Kawaguchi Y, Shimauchi R, Nishibori N, et al. Dipeptidyl peptidase-4 inhibitors-associated bullous pemphigoid: A retrospective study of 168 pemphigoid and 9,304 diabetes mellitus patients. Journal of diabetes investigation. 2019;10(2):392-398.
2018
  1. Kano M, Suga H, Kasai T, Ozone C, Arima H: Functional Pituitary Tissue Generation from Human Embryonic Stem Cells. Curr Protoc Neurosci 2018, 83:e48.
  2. Kimbara S, Fujiwara Y, Iwama S, Ohashi K, Kuchiba A, Arima H, Yamazaki N, Kitano S, Yamamoto N, Ohe Y: Association of antithyroglobulin antibodies with the development of thyroid dysfunction induced by nivolumab. Cancer Sci 2018, 109:3583-3590.
  3. Kobayashi T, Iwama S, Yasuda Y, Okada N, Tsunekawa T, Onoue T, Takagi H, Hagiwara D, Ito Y, Morishita Y, et al: Patients With Antithyroid Antibodies Are Prone To Develop Destructive Thyroiditis by Nivolumab: A Prospective Study. J Endocr Soc 2018, 2:241-251.
  4. Maekawa R, Ogata H, Murase M, Harada N, Suzuki K, Joo E, Sankoda A, Iida A, Izumoto T, Tsunekawa S, et al: Glucose-dependent insulinotropic polypeptide is required for moderate high-fat diet- but not high-carbohydrate diet-induced weight gain. Am J Physiol Endocrinol Metab 2018, 314:E572-e583.
  5. Nakashima K, Takeuchi S, Iwama S, Kiyota A, Yasuda Y, Iwata N, Enomoto A, Arima H, Sugimura Y: Cullin-associated NEDD8-dissociated protein 1, a novel interactor of rabphilin-3A, deubiquitylates rabphilin-3A and regulates arginine vasopressin secretion in PC12 cells. Endocr J 2018, 65:325-334.
  6. Ogawa K, Suga H, Ozone C, Sakakibara M, Yamada T, Kano M, Mitsumoto K, Kasai T, Kodani Y, Nagasaki H, et al: Vasopressin-secreting neurons derived from human embryonic stem cells through specific induction of dorsal hypothalamic progenitors. Sci Rep 2018, 8:3615.
  7. Tochiya M, Hagiwara D, Azuma Y, Miyata T, Morishita Y, Suga H, Onoue T, Tsunekawa T, Takagi H, Ito Y, et al: Chemical chaperone 4-phenylbutylate reduces mutant protein accumulation in the endoplasmic reticulum of arginine vasopressin neurons in a mouse model for familial neurohypophysial diabetes insipidus. Neurosci Lett 2018, 682:50-55.
  8. Yasuda Y, Iwama S, Kiyota A, Izumida H, Nakashima K, Iwata N, Ito Y, Morishita Y, Goto M, Suga H, et al: Critical role of rabphilin-3A in the pathophysiology of experimental lymphocytic neurohypophysitis. J Pathol 2018, 244:469-478.
  9. Siriguleng S, Koike T, Natsume Y, Iwama S, Oshida Y: Effect of prior chronic aerobic exercise on overload-induced skeletal muscle hypertrophy in mice. Physiol Res 2018, 67:765-775.
2017
  1. Hosokawa K, Hamada Y, Fujiya A, Murase M, Maekawa R, Niwa Y, Izumoto T, Seino Y, Tsunekawa S, Arima H: S100B impairs glycolysis via enhanced poly(ADP-ribosyl)ation of glyceraldehyde-3-phosphate dehydrogenase in rodent muscle cells. Am J Physiol Endocrinol Metab 2017, 312:E471-e481.
  2. Iwata N, Iwama S, Sugimura Y, Yasuda Y, Nakashima K, Takeuchi S, Hagiwara D, Ito Y, Suga H, Goto M, et al: Anti-pituitary antibodies against corticotrophs in IgG4-related hypophysitis. Pituitary 2017, 20:301-310.
  3. Maekawa R, Seino Y, Ogata H, Murase M, Iida A, Hosokawa K, Joo E, Harada N, Tsunekawa S, Hamada Y, et al: Chronic high-sucrose diet increases fibroblast growth factor 21 production and energy expenditure in mice. J Nutr Biochem 2017, 49:71-79.
  4. Muraoka Y, Iwama S, Arima H: Normalization of Bilateral Adrenal Gland Enlargement after Treatment for Cryptococcosis. Case Rep Endocrinol 2017, 2017:1543149.
  5. Onoue T, Goto M, Kobayashi T, Tominaga T, Ando M, Honda H, Yoshida Y, Tosaki T, Yokoi H, Kato S, et al: Randomized controlled trial for assessment of Internet of Things system to guide intensive glucose control in diabetes outpatients: Nagoya Health Navigator Study protocol. Nagoya J Med Sci 2017, 79:323-329.
  6. Sugiyama M, Banno R, Mizoguchi A, Tominaga T, Tsunekawa T, Onoue T, Hagiwara D, Ito Y, Morishita Y, Iwama S, et al: PTP1B deficiency improves hypothalamic insulin sensitivity resulting in the attenuation of AgRP mRNA expression under high-fat diet conditions. Biochem Biophys Res Commun 2017, 488:116-121.
  7. Tominaga T, Goto M, Onoue T, Mizoguchi A, Sugiyama M, Tsunekawa T, Hagiwara D, Morishita Y, Ito Y, Iwama S, et al: Sequestosome 1 (SQSTM1/p62) maintains protein folding capacity under endoplasmic reticulum stress in mouse hypothalamic organotypic culture. Neurosci Lett 2017, 656:103-107.
  8. Tsunekawa T, Banno R, Mizoguchi A, Sugiyama M, Tominaga T, Onoue T, Hagiwara D, Ito Y, Iwama S, Goto M, et al: Deficiency of PTP1B Attenuates Hypothalamic Inflammation via Activation of the JAK2-STAT3 Pathway in Microglia. EBioMedicine 2017, 16:172-183.
  9. Ozone C, Suga H: Functional Pituitary Tissue Formation. Methods Mol Biol 2017, 1597:57-65.
2016
  1. Fujisawa H, Sugimura Y, Takagi H, Mizoguchi H, Takeuchi H, Izumida H, Nakashima K, Ochiai H, Takeuchi S, Kiyota A, Fukumoto K, Iwama S, Takagishi Y, Hayashi Y, Arima H, Komatsu Y, Murata Y, Oiso Y. Chronic Hyponatremia Causes Neurologic and Psychologic Impairments. J Am Soc Nephrol, 2016; 27: 766-780.
  2. Iida A, Seino Y, Fukami A, Maekawa R, Yabe D, Shimizu S, Kinoshita K, Takagi Y, Izumoto T, Ogata H, Ishikawa K, Ozaki N, Tsunekawa S, Hamada Y, Oiso Y, Arima H, Hayashi Y. Endogenous GIP ameliorates impairment of insulin secretion in proglucagon-deficient mice under moderate beta cell damage induced by streptozotocin. Diabetologia, 2016; 59: 1533-1541.
  3. Izumida H, Takagi H, Fujisawa H, Iwata N, Nakashima K, Takeuchi S, Iwama S, Namba T, Komatu Y, Kaibuchi K, Oiso Y, Arima H, Sugimura Y. NMDA receptor antagonist prevents cell death in the hippocampal dentate gyrus induced by hyponatremia accompanying adrenal insufficiency in rats. Exp Neurol, 2016.
  4. Lu W, Hagiwara D, Morishita Y, Tochiya M, Azuma Y, Suga H, Goto M, Banno R, Sugimura Y, Oyadomari S, Mori K, Arima H. Unfolded protein response in hypothalamic cultures of wild-type and ATF6alpha-knockout mice. Neurosci Lett, 2016; 612: 199-203.
  5. Onoue T, Goto M, Tominaga T, Sugiyama M, Tsunekawa T, Hagiwara D, Banno R, Suga H, Sugimura Y, Arima H. Reactive oxygen species mediate insulin signal transduction in mouse hypothalamus. Neurosci Lett, 2016; 619: 1-7.
  6. Shibata M, Banno R, Sugiyama M, Tominaga T, Onoue T, Tsunekawa T, Azuma Y, Hagiwara D, Lu W, Ito Y, Goto M, Suga H, Sugimura Y, Oiso Y, Arima H. AgRP Neuron-Specific Deletion of Glucocorticoid Receptor Leads to Increased Energy Expenditure and Decreased Body Weight in Female Mice on a High-Fat Diet. Endocrinology, 2016; 157: 1457-1466.
  7. Takeuchi S, Iwama S, Takagi H, Kiyota A, Nakashima K, Izumida H, Fujisawa H, Iwata N, Suga H, Watanabe T, Kaibuchi K, Oiso Y, Arima H, Sugimura Y. Tomosyn Negatively Regulates Arginine Vasopressin Secretion in Embryonic Stem Cell-Derived Neurons. PLoS One, 2016; 11: e0164544.
  8. Ozone C, Suga H, Eiraku M, Kadoshima T, Yonemura S, Takata N, Oiso Y, Tsuji T, Sasai Y. Functional anterior pituitary generated in self-organizing culture of human embryonic stem cells. Nat Commun, 2016; 7: 10351.
  9. Seino Y, Maekawa R, Ogata H, Hayashi Y. Carbohydrate-induced secretion of glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1. J Diabetes Investig, 2016; 7 Suppl 1: 27-32.
  10. Ji S, Tokizane K, Ohkawa Y, Ohmi Y, Banno R, Okajima T, Kiyama H, Furukawa K, Furukawa K. Increased a-series gangliosides positively regulate leptin/Ob receptor-mediated signals in hypothalamus of GD3 synthase-deficient mice. Biochem Biophys Res Commun, 2016; 479: 453-460.
2015
  1. Iwama S, Sugimura Y, Kiyota A, Kato T, Enomoto A, Suzuki H, Iwata N, Takeuchi S, Nakashima K, Takagi H, Izumida H, Ochiai H, Fujisawa H, Suga H, Arima H, Shimoyama Y, Takahashi M, Nishioka H, Ishikawa SE, Shimatsu A, Caturegli P, Oiso Y. Rabphilin-3A as a Targeted Autoantigen in Lymphocytic Infundibulo-neurohypophysitis. J Clin Endocrinol Metab, 2015; 100: E946-954.
  2. Izumoto-Akita T, Tsunekawa S, Yamamoto A, Uenishi E, Ishikawa K, Ogata H, Iida A, Ikeniwa M, Hosokawa K, Niwa Y, Maekawa R, Yamauchi Y, Seino Y, Hamada Y, Hibi H, Arima H, Ueda M, Oiso Y. Secreted factors from dental pulp stem cells improve glucose intolerance in streptozotocin-induced diabetic mice by increasing pancreatic beta-cell function. BMJ Open Diabetes Res Care, 2015; 3: e000128.
  3. Kataoka Y, Nishida S, Hirakawa A, Oiso Y, Arima H. Comparison of incidence of hyponatremia between intranasal and oral desmopressin in patients with central diabetes insipidus. Endocr J, 2015; 62: 195-200.
  4. Kiyota A, Iwama S, Sugimura Y, Takeuchi S, Takagi H, Iwata N, Nakashima K, Suzuki H, Nishioka T, Kato T, Enomoto A, Arima H, Kaibuchi K, Oiso Y. Identification of the novel autoantigen candidate Rab GDP dissociation inhibitor alpha in isolated adrenocorticotropin deficiency. Endocr J, 2015; 62: 153-160.
  5. Niwa Y, Ishikawa K, Ishigami M, Honda T, Achiwa K, Izumoto T, Maekawa R, Hosokawa K, Iida A, Seino Y, Hamada Y, Goto H, Oiso Y, Arima H, Tsunekawa S. Effect of hyperglycemia on hepatocellular carcinoma development in diabetes. Biochem Biophys Res Commun, 2015; 463: 344-350.
  6. Ochiai H, Suga H, Yamada T, Sakakibara M, Kasai T, Ozone C, Ogawa K, Goto M, Banno R, Tsunekawa S, Sugimura Y, Arima H, Oiso Y. BMP4 and FGF strongly induce differentiation of mouse ES cells into oral ectoderm. Stem Cell Res, 2015; 15: 290-298.
  7. Takahashi A, Lee RX, Iwasato T, Itohara S, Arima H, Bettler B, Miczek KA, Koide T. Glutamate input in the dorsal raphe nucleus as a determinant of escalated aggression in male mice. J Neurosci, 2015; 35: 6452-6463.
  8. Ishikawa K, Tsunekawa S, Ikeniwa M, Izumoto T, Iida A, Ogata H, Uenishi E, Seino Y, Ozaki N, Sugimura Y, Hamada Y, Kuroda A, Shinjo K, Kondo Y, Oiso Y. Long-term pancreatic beta cell exposure to high levels of glucose but not palmitate induces DNA methylation within the insulin gene promoter and represses transcriptional activity. PLoS One, 2015; 10: e0115350.
  9. Seino Y, Ogata H, Maekawa R, Izumoto T, Iida A, Harada N, Miki T, Seino S, Inagaki N, Tsunekawa S, Oiso Y, Hamada Y. Fructose induces glucose-dependent insulinotropic polypeptide, glucagon-like peptide-1 and insulin secretion: Role of adenosine triphosphate-sensitive K(+) channels. J Diabetes Investig, 2015; 6: 522-526.
  10. Ji S, Ohkawa Y, Tokizane K, Ohmi Y, Banno R, Furukawa K, Kiyama H, Furukawa K. b-Series gangliosides crucially regulate leptin secretion in adipose tissues. Biochem Biophys Res Commun, 2015; 459: 189-195.
2014
  1. Adachi K, Goto M, Onoue T, Tsunekawa T, Shibata M, Hagimoto S, Ito Y, Banno R, Suga H, Sugimura Y, Oiso Y, Arima H. Mitogen-activated protein kinase phosphatase 1 negatively regulates MAPK signaling in mouse hypothalamus. Neurosci Lett, 2014; 569: 49-54.
  2. Arima H, Morishita Y, Hagiwara D, Hayashi M, Oiso Y. Endoplasmic reticulum stress in vasopressin neurons of familial diabetes insipidus model mice: aggregate formation and mRNA poly(A) tail shortening. Exp Physiol, 2014; 99: 66-71.
  3. Arima H, Wakabayashi T, Nagatani T, Fujii M, Hirakawa A, Murase T, Yambe Y, Yamada T, Yamakawa F, Yamamori I, Yamauchi M, Oiso Y. Adipsia increases risk of death in patients with central diabetes insipidus. Endocr J, 2014; 61: 143-148.
  4. Azuma Y, Hagiwara D, Lu W, Morishita Y, Suga H, Goto M, Banno R, Sugimura Y, Oyadomari S, Mori K, Shiota A, Asai N, Takahashi M, Oiso Y, Arima H. Activating transcription factor 6alpha is required for the vasopressin neuron system to maintain water balance under dehydration in male mice. Endocrinology, 2014; 155: 4905-4914.
  5. Hagiwara D, Arima H, Morishita Y, Wenjun L, Azuma Y, Ito Y, Suga H, Goto M, Banno R, Sugimura Y, Shiota A, Asai N, Takahashi M, Oiso Y. Arginine vasopressin neuronal loss results from autophagy-associated cell death in a mouse model for familial neurohypophysial diabetes insipidus. Cell Death Dis, 2014; 5: e1148.
  6. Takagi H, Sugimura Y, Suzuki H, Iwama S, Izumida H, Fujisawa H, Ogawa K, Nakashima K, Ochiai H, Takeuchi S, Kiyota A, Suga H, Goto M, Banno R, Arima H, Oiso Y. Minocycline prevents osmotic demyelination associated with aquaresis. Kidney Int, 2014; 86: 954-964.
  7. Kato J, Kamiya H, Himeno T, Shibata T, Kondo M, Okawa T, Fujiya A, Fukami A, Uenishi E, Seino Y, Tsunekawa S, Hamada Y, Naruse K, Oiso Y, Nakamura J. Mesenchymal stem cells ameliorate impaired wound healing through enhancing keratinocyte functions in diabetic foot ulcerations on the plantar skin of rats. J Diabetes Complications, 2014; 28: 588-595.
  8. Okawa T, Kamiya H, Himeno T, Seino Y, Tsunekawa S, Hayashi Y, Harada N, Yamada Y, Inagaki N, Seino Y, Oiso Y, Nakamura J. Sensory and motor physiological functions are impaired in gastric inhibitory polypeptide receptor-deficient mice. J Diabetes Investig, 2014; 5: 31-37.
  9. Fujiya A, Nagasaki H, Seino Y, Okawa T, Kato J, Fukami A, Himeno T, Uenishi E, Tsunekawa S, Kamiya H, Nakamura J, Oiso Y, Hamada Y. The role of S100B in the interaction between adipocytes and macrophages. Obesity (Silver Spring), 2014; 22: 371-379.
  10. Ogata H, Seino Y, Harada N, Iida A, Suzuki K, Izumoto T, Ishikawa K, Uenishi E, Ozaki N, Hayashi Y, Miki T, Inagaki N, Tsunekawa S, Hamada Y, Seino S, Oiso Y. KATP channel as well as SGLT1 participates in GIP secretion in the diabetic state. J Endocrinol, 2014; 222: 191-200.
2013
  1. Arima H, Oiso Y, Juul KV, Norgaard JP. Efficacy and safety of desmopressin orally disintegrating tablet in patients with central diabetes insipidus: results of a multicenter open-label dose-titration study. Endocr J, 2013; 60: 1085-1094.
  2. Hagimoto S, Arima H, Adachi K, Ito Y, Suga H, Sugimura Y, Goto M, Banno R, Oiso Y. Expression of neuropeptide Y and agouti-related protein mRNA stimulated by glucocorticoids is attenuated via NF-kappaB p65 under ER stress in mouse hypothalamic cultures. Neurosci Lett, 2013; 553: 165-169.
  3. Ito Y, Banno R, Shibata M, Adachi K, Hagimoto S, Hagiwara D, Ozawa Y, Goto M, Suga H, Sugimura Y, Bettler B, Oiso Y, Arima H. GABA type B receptor signaling in proopiomelanocortin neurons protects against obesity, insulin resistance, and hypothalamic inflammation in male mice on a high-fat diet. J Neurosci, 2013; 33: 17166-17173.
  4. Hamada Y, Nagasaki H, Fuchigami M, Furuta S, Seino Y, Nakamura J, Oiso Y. The alpha-glucosidase inhibitor miglitol affects bile acid metabolism and ameliorates obesity and insulin resistance in diabetic mice. Metabolism, 2013; 62: 734-742.
  5. Okawa T, Kamiya H, Himeno T, Kato J, Seino Y, Fujiya A, Kondo M, Tsunekawa S, Naruse K, Hamada Y, Ozaki N, Cheng Z, Kito T, Suzuki H, Ito S, Oiso Y, Nakamura J, Isobe K. Transplantation of neural crest-like cells derived from induced pluripotent stem cells improves diabetic polyneuropathy in mice. Cell Transplant, 2013; 22: 1767-1783.
  6. Fukami A, Seino Y, Ozaki N, Yamamoto M, Sugiyama C, Sakamoto-Miura E, Himeno T, Takagishi Y, Tsunekawa S, Ali S, Drucker DJ, Murata Y, Seino Y, Oiso Y, Hayashi Y. Ectopic expression of GIP in pancreatic beta-cells maintains enhanced insulin secretion in mice with complete absence of proglucagon-derived peptides. Diabetes, 2013; 62: 510-518.
  7. Okawa T, Tsunekawa S, Seino Y, Hamada Y, Oiso Y. Deceptive HbA(1)c in a patient with pure red cell aplasia. Lancet, 2013; 382: 366.
  8. Hayashi M, Kataoka Y, Sugimura Y, Kato F, Fukami M, Ogata T, Homma K, Hasegawa T, Oiso Y, Sasano H, Tanaka H. A 68-year-old phenotypically male patient with 21-hydroxylase deficiency and concomitant adrenocortical neoplasm producing testosterone and cortisol. Tohoku J Exp Med, 2013; 231: 75-84.
2012
  1. Hagiwara D, Arima H, Morishita Y, Goto M, Banno R, Sugimura Y, Oiso Y. BiP mRNA expression is upregulated by dehydration in vasopressin neurons in the hypothalamus in mice. Peptides, 2012; 33: 346-350.
  2. Ito Y, Banno R, Hagimoto S, Ozawa Y, Arima H, Oiso Y. TNFalpha increases hypothalamic PTP1B activity via the NFkappaB pathway in rat hypothalamic organotypic cultures. Regul Pept, 2012; 174: 58-64.
  3. Mizutani N, Ozaki N, Seino Y, Fukami A, Sakamoto E, Fukuyama T, Sugimura Y, Nagasaki H, Arima H, Oiso Y. Reduction of insulin signaling upregulates angiopoietin-like protein 4 through elevated free fatty acids in diabetic mice. Exp Clin Endocrinol Diabetes, 2012; 120: 139-144.
  4. Nagasaki H, Kondo T, Fuchigami M, Hashimoto H, Sugimura Y, Ozaki N, Arima H, Ota A, Oiso Y, Hamada Y. Inflammatory changes in adipose tissue enhance expression of GPR84, a medium-chain fatty acid receptor: TNFalpha enhances GPR84 expression in adipocytes. FEBS Lett, 2012; 586: 368-372.
  5. Ozawa Y, Arima H, Banno R, Ito Y, Goto M, Morishita Y, Sugimura Y, Ozaki N, Nagasaki H, Oiso Y. Lesion of area postrema attenuated hyperphagic responses to glucoprivation, but not transcriptional activation of the neuropeptide Y gene in rats. Neuroreport, 2012; 23: 673-675.
  6. Sakamoto E, Seino Y, Fukami A, Mizutani N, Tsunekawa S, Ishikawa K, Ogata H, Uenishi E, Kamiya H, Hamada Y, Sato H, Harada N, Toyoda Y, Miwa I, Nakamura J, Inagaki N, Oiso Y, Ozaki N. Ingestion of a moderate high-sucrose diet results in glucose intolerance with reduced liver glucokinase activity and impaired glucagon-like peptide-1 secretion. J Diabetes Investig, 2012; 3: 432-440.
  7. Watanabe C, Seino Y, Miyahira H, Yamamoto M, Fukami A, Ozaki N, Takagishi Y, Sato J, Fukuwatari T, Shibata K, Oiso Y, Murata Y, Hayashi Y. Remodeling of hepatic metabolism and hyperaminoacidemia in mice deficient in proglucagon-derived peptides. Diabetes, 2012; 61: 74-84.
2011
  1. Iwama S, Sugimura Y, Suzuki H, Suzuki H, Murase T, Ozaki N, Nagasaki H, Arima H, Murata Y, Sawada M, Oiso Y. Time-dependent changes in proinflammatory and neurotrophic responses of microglia and astrocytes in a rat model of osmotic demyelination syndrome. Glia, 2011; 59: 452-462.
  2. Morishita Y, Arima H, Hiroi M, Hayashi M, Hagiwara D, Asai N, Ozaki N, Sugimura Y, Nagasaki H, Shiota A, Takahashi M, Oiso Y. Poly(A) tail length of neurohypophysial hormones is shortened under endoplasmic reticulum stress. Endocrinology, 2011; 152: 4846-4855.
  3. Ozawa Y, Arima H, Watanabe M, Shimizu H, Ito Y, Banno R, Sugimura Y, Ozaki N, Nagasaki H, Oiso Y. Repeated glucoprivation delayed hyperphagic responses while activating neuropeptide Y neurons in rats. Peptides, 2011; 32: 763-769.
  4. Himeno T, Kamiya H, Naruse K, Harada N, Ozaki N, Seino Y, Shibata T, Kondo M, Kato J, Okawa T, Fukami A, Hamada Y, Inagaki N, Seino Y, Drucker DJ, Oiso Y, Nakamura J. Beneficial effects of exendin-4 on experimental polyneuropathy in diabetic mice. Diabetes, 2011; 60: 2397-2406.
2010
  1. Arima H, Oiso Y. Positive effect of baclofen on body weight reduction in obese subjects: a pilot study. Intern Med, 2010; 49: 2043-2047.
  2. Arima H, Oiso Y. Mechanisms underlying progressive polyuria in familial neurohypophysial diabetes insipidus. J Neuroendocrinol, 2010; 22: 754-757.
  3. Hiroi M, Morishita Y, Hayashi M, Ozaki N, Sugimura Y, Nagasaki H, Shiota A, Oiso Y, Arima H. Activation of vasopressin neurons leads to phenotype progression in a mouse model for familial neurohypophysial diabetes insipidus. Am J Physiol Regul Integr Comp Physiol, 2010; 298: R486-493.
  4. Kawada K, Kitagawa K, Kamei S, Inada M, Mitsuma A, Sawaki M, Kikumori T, Fujimoto Y, Arima H, Imai T, Ando Y. The feasibility study of docetaxel in patients with anaplastic thyroid cancer. Jpn J Clin Oncol, 2010; 40: 596-599.
  5. Shimizu H, Arima H, Ozawa Y, Watanabe M, Banno R, Sugimura Y, Ozaki N, Nagasaki H, Oiso Y. Glucocorticoids increase NPY gene expression in the arcuate nucleus by inhibiting mTOR signaling in rat hypothalamic organotypic cultures. Peptides, 2010; 31: 145-149.
  6. Suzuki H, Sugimura Y, Iwama S, Suzuki H, Nobuaki O, Nagasaki H, Arima H, Sawada M, Oiso Y. Minocycline prevents osmotic demyelination syndrome by inhibiting the activation of microglia. J Am Soc Nephrol, 2010; 21: 2090-2098.
  7. Umeda H, Ozaki N, Mizutani N, Fukuyama T, Nagasaki H, Arima H, Oiso Y. Protective effect of hedgehog signaling on cytokine-induced cytotoxicity in pancreatic beta-cells. Exp Clin Endocrinol Diabetes, 2010; 118: 692-698.
  8. Yokota F, Arima H, Hirano M, Uchikawa T, Inden Y, Nagatani T, Oiso Y. Normalisation of plasma growth hormone levels improved cardiac dysfunction due to acromegalic cardiomyopathy with severe fibrosis. BMJ Case Rep, 2010; 2010.
2009
  1. Arima H, Imamine R, Oiso Y. Ping-pong champion with adrenal insufficiency. BMJ Case Rep, 2009; 2009.
  2. Hayashi M, Arima H, Ozaki N, Morishita Y, Hiroi M, Ozaki N, Nagasaki H, Kinoshita N, Ueda M, Shiota A, Oiso Y. Progressive polyuria without vasopressin neuron loss in a mouse model for familial neurohypophysial diabetes insipidus. Am J Physiol Regul Integr Comp Physiol, 2009; 296: R1641-1649.
  3. Imamine R, Arima H, Kusakabe M, Umeda H, Sato I, Homma K, Usui T, Oiso Y. Genetic analysis of two Japanese patients with non-classical 21-hydroxylase deficiency. Intern Med, 2009; 48: 705-709.
  4. Iwama S, Sugimura Y, Murase T, Hiroi M, Goto M, Hayashi M, Arima H, Oiso Y. Central adiponectin functions to inhibit arginine vasopressin release in conscious rats. J Neuroendocrinol, 2009; 21: 753-759.
  5. Suzuki C, Nagasaki H, Okajima Y, Suga H, Ozaki N, Arima H, Iwasaki Y, Oiso Y. Inflammatory cytokines regulate glycoprotein subunit beta5 of thyrostimulin through nuclear factor-kappaB. Endocrinology, 2009; 150: 2237-2243.
  6. Watanabe M, Arima H, Ozawa Y, Goto M, Shimizu H, Banno R, Sugimura Y, Ozaki N, Nagasaki H, Oiso Y. The medial hypothalamus is required for the feeding response to glucoprivation but not to food deprivation. Neurosci Lett, 2009; 464: 6-9.
  7. Oyama K, Sugimura Y, Murase T, Uchida A, Hayasaka S, Oiso Y, Murata Y. Folic acid prevents congenital malformations in the offspring of diabetic mice. Endocr J, 2009; 56: 29-37.
  8. Sugimura Y, Murase T, Kobayashi K, Oyama K, Hayasaka S, Kanou Y, Oiso Y, Murata Y. Alpha-lipoic acid reduces congenital malformations in the offspring of diabetic mice. Diabetes Metab Res Rev, 2009; 25: 287-294.
  9. Sugimura Y, Murase T, Oyama K, Uchida A, Sato N, Hayasaka S, Kano Y, Takagishi Y, Hayashi Y, Oiso Y, Murata Y. Prevention of neural tube defects by loss of function of inducible nitric oxide synthase in fetuses of a mouse model of streptozotocin-induced diabetes. Diabetologia, 2009; 52: 962-971.
2008
  1. Okajima Y, Nagasaki H, Suzuki C, Suga H, Ozaki N, Arima H, Hamada Y, Civelli O, Oiso Y. Biochemical roles of the oligosaccharide chains in thyrostimulin, a heterodimeric hormone of glycoprotein hormone subunits alpha 2 (GPA2) and beta 5 (GPB5). Regul Pept, 2008; 148: 62-67.
  2. Shimizu H, Arima H, Watanabe M, Goto M, Banno R, Sato I, Ozaki N, Nagasaki H, Oiso Y. Glucocorticoids increase neuropeptide Y and agouti-related peptide gene expression via adenosine monophosphate-activated protein kinase signaling in the arcuate nucleus of rats. Endocrinology, 2008; 149: 4544-4553.
  3. Suga H, Nagasaki H, Kondo TA, Okajima Y, Suzuki C, Ozaki N, Arima H, Yamamoto T, Ozaki N, Akai M, Sato A, Uozumi N, Inoue M, Hasegawa M, Oiso Y. Novel treatment for lithium-induced nephrogenic diabetes insipidus rat model using the Sendai-virus vector carrying aquaporin 2 gene. Endocrinology, 2008; 149: 5803-5810.
  4. Watanabe M, Arima H, Fukushima K, Goto M, Shimizu H, Hayashi M, Banno R, Sato I, Ozaki N, Nagasaki H, Oiso Y. Direct and indirect modulation of neuropeptide Y gene expression in response to hypoglycemia in rat arcuate nucleus. FEBS Lett, 2008; 582: 3632-3638.
2007
  1. Banno R, Arima H, Hayashi M, Goto M, Watanabe M, Sato I, Ozaki N, Nagasaki H, Ozaki N, Oiso Y. Central administration of melanocortin agonist increased insulin sensitivity in diet-induced obese rats. FEBS Lett, 2007; 581: 1131-1136.
  2. Goto M, Arima H, Hiroi M, Shimizu H, Watanabe M, Hayashi M, Banno R, Sato I, Ozaki N, Nagasaki H, Oiso Y. Insulin is not a prerequisite for rapid regulation of neuropeptide Y gene transcription in the arcuate nucleus in food-restricted rats. Neurosci Lett, 2007; 420: 61-65.
  3. Sato I, Arima H, Ozaki N, Ozaki N, Watanabe M, Goto M, Shimizu H, Hayashi M, Banno R, Nagasaki H, Oiso Y. Peripherally administered baclofen reduced food intake and body weight in db/db as well as diet-induced obese mice. FEBS Lett, 2007; 581: 4857-4864.
  4. Suzuki C, Nagasaki H, Okajima Y, Suga H, Arima H, Iwasaki Y, Oiso Y. The LIM domain homeobox gene isl-1 is a positive regulator of glycoprotein alpha 2 (GPA2), a subunit of thyrostimulin. Regul Pept, 2007; 142: 60-67.
  5. Takefuji S, Murase T, Sugimura Y, Takagishi Y, Hayasaka S, Oiso Y, Murata Y. Role of microglia in the pathogenesis of osmotic-induced demyelination. Exp Neurol, 2007; 204: 88-94.
2006
  1. Goto M, Arima H, Watanabe M, Hayashi M, Banno R, Sato I, Nagasaki H, Oiso Y. Ghrelin increases neuropeptide Y and agouti-related peptide gene expression in the arcuate nucleus in rat hypothalamic organotypic cultures. Endocrinology, 2006; 147: 5102-5109.
  2. Hayashi M, Arima H, Goto M, Banno R, Watanabe M, Sato I, Nagasaki H, Oiso Y. Vasopressin gene transcription increases in response to decreases in plasma volume, but not to increases in plasma osmolality, in chronically dehydrated rats. Am J Physiol Endocrinol Metab, 2006; 290: E213-217.
  3. Murase T, Sugimura Y, Takefuji S, Oiso Y, Murata Y. Mechanisms and therapy of osmotic demyelination. Am J Med, 2006; 119: S69-73.
2005
  1. Sato I, Arima H, Ozaki N, Watanabe M, Goto M, Hayashi M, Banno R, Nagasaki H, Oiso Y. Insulin inhibits neuropeptide Y gene expression in the arcuate nucleus through GABAergic systems. J Neurosci, 2005; 25: 8657-8664.
  2. Sugimura Y, Murase T, Takefuji S, Hayasaka S, Takagishi Y, Oiso Y, Murata Y. Protective effect of dexamethasone on osmotic-induced demyelination in rats. Exp Neurol, 2005; 192: 178-183.
2004
  1. Banno R, Arima H, Sato I, Hayashi M, Goto M, Sugimura Y, Murase T, Oiso Y. The melanocortin agonist melanotan II increases insulin sensitivity in OLETF rats. Peptides, 2004; 25: 1279-1286.
  2. Ishizaki S, Murase T, Sugimura Y, Banno R, Arima H, Miura Y, Oiso Y. Leukemia inhibitory factor stimulates vasopressin release in rats. Neurosci Lett, 2004; 359: 77-80.
  3. Kondo N, Arima H, Banno R, Kuwahara S, Sato I, Oiso Y. Osmoregulation of vasopressin release and gene transcription under acute and chronic hypovolemia in rats. Am J Physiol Endocrinol Metab, 2004; 286: E337-346.
2003
  1. Kuwahara S, Arima H, Banno R, Sato I, Kondo N, Oiso Y. Regulation of vasopressin gene expression by cAMP and glucocorticoids in parvocellular neurons of the paraventricular nucleus in rat hypothalamic organotypic cultures. J Neurosci, 2003; 23: 10231-10237.
  2. Sugimura Y, Murase T, Ishizaki S, Tachikawa K, Arima H, Miura Y, Usdin TB, Oiso Y. Centrally administered tuberoinfundibular peptide of 39 residues inhibits arginine vasopressin release in conscious rats. Endocrinology, 2003; 144: 2791-2796.
  3. Tachikawa K, Yokoi H, Nagasaki H, Arima H, Murase T, Sugimura Y, Miura Y, Hirabayashi M, Oiso Y. Altered cardiovascular regulation in arginine vasopressin-overexpressing transgenic rat. Am J Physiol Endocrinol Metab, 2003; 285: E1161-1166.
2002
  1. Ishizaki S, Murase T, Sugimura Y, Kakiya S, Yokoi H, Tachikawa K, Arima H, Miura Y, Oiso Y. Role of ghrelin in the regulation of vasopressin release in conscious rats. Endocrinology, 2002; 143: 1589-1593.
  2. Nagasaki H, Yokoi H, Arima H, Hirabayashi M, Ishizaki S, Tachikawa K, Murase T, Miura Y, Oiso Y. Overexpression of vasopressin in the rat transgenic for the metallothionein-vasopressin fusion gene. J Endocrinol, 2002; 173: 35-44.
  3. Yambe Y, Arima H, Kakiya S, Murase T, Oiso Y. Diurnal changes in arginine vasopressin gene transcription in the rat suprachiasmatic nucleus. Brain Res Mol Brain Res, 2002; 104: 132-136.
  4. Yokoi H, Nagasaki H, Tachikawa K, Arima H, Murase T, Miura Y, Hirabayashi M, Oiso Y. Adaptation to sustained high plasma vasopressin in water and electrolyte homeostasis in the rat transgenic for the metallothionein-vasopressin fusion gene. J Endocrinol, 2002; 173: 23-33.
2000
  1. Kakiya S, Arima H, Yokoi H, Murase T, Yambe Y, Oiso Y. Effects of acute hypotensive stimuli on arginine vasopressin gene transcription in the rat hypothalamus. Am J Physiol Endocrinol Metab, 2000; 279: E886-892.
  2. Kakiya S, Murase T, Arima H, Yokoi H, Iwasaki Y, Miura Y, Oiso Y. Role of endogenous nociceptin in the regulation of arginine vasopressin release in conscious rats. Endocrinology, 2000; 141: 4466-4471.
  3. Yambe Y, Watanabe-Tomita Y, Kakiya S, Yokoi H, Nagasaki H, Arima H, Murase T, Yuasa H, Kondo K, Yamashita H, Oiso Y. Analysis of the vasopressin system and water regulation in genetically polydipsic mice. Am J Physiol Endocrinol Metab, 2000; 278: E189-194.
1999
  1. Arima H, Kondo K, Kakiya S, Nagasaki H, Yokoi H, Yambe Y, Murase T, Iwasaki Y, Oiso Y. Rapid and sensitive vasopressin heteronuclear RNA responses to changes in plasma osmolality. J Neuroendocrinol, 1999; 11: 337-341.
1998
  1. Arima H, Kondo K, Murase T, Yokoi H, Iwasaki Y, Saito H, Oiso Y. Regulation of vasopressin synthesis and release by area postrema in rats. Endocrinology, 1998; 139: 1481-1486.
  2. Kakiya S, Yokoi H, Arima H, Iwasaki Y, Oki Y, Oiso Y. Central administration of urocortin inhibits vasopressin release in conscious rats. Neurosci Lett, 1998; 248: 144-146.
  3. Mizuno Y, Kondo K, Terashima Y, Arima H, Murase T, Oiso Y. Anorectic effect of pituitary adenylate cyclase activating polypeptide (PACAP) in rats: lack of evidence for involvement of hypothalamic neuropeptide gene expression. J Neuroendocrinol, 1998; 10: 611-616.
  4. Terashima Y, Kondo K, Inagaki A, Yokoi H, Arima H, Murase T, Iwasaki Y, Oiso Y. Age-associated decrease in response of rat aquaporin-2 gene expression to dehydration. Life Sci, 1998; 62: 873-882.
  5. Yokoi H, Arima H, Kondo K, Murase T, Iwasaki Y, Yang HY, Oiso Y. Antiserum against neuropeptide FF augments vasopressin release in conscious rats. Peptides, 1998; 19: 393-395.
1996
  1. Arima H, Murase T, Kondo K, Iwasaki Y, Oiso Y. Centrally administered neuropeptide FF inhibits arginine vasopressin release in conscious rats. Endocrinology, 1996; 137: 1523-1529.
  2. Murase T, Arima H, Kondo K, Oiso Y. Neuropeptide FF reduces food intake in rats. Peptides, 1996; 17: 353-354.
  3. Yokoi H, Arima H, Murase T, Kondo K, Iwasaki Y, Oiso Y. Intracerebroventricular injection of adrenomedullin inhibits vasopressin release in conscious rats. Neurosci Lett, 1996; 216: 65-67.
1995
  1. Murase T, Kondo K, Arima H, Iwasaki Y, Ito M, Miura Y, Oiso Y. The expression of pituitary adenylate cyclase-activating polypeptide (PACAP) mRNA in rat brain: possible role of endogenous PACAP in vasopressin release. Neurosci Lett, 1995; 185: 103-106.

Laboratory Members

endocrinology-diabetes_img01.jpg

Back to top of page