Introduction

The Department of Ophthalmology of the Nagoya University Medical School was founded in 1882, and throughout its long history, the clinical and experimental programs have been focused on the diagnosis and treatment of retinal diseases. Thus, the department has performed clinical and laboratory research designed to improve the diagnosis and treatment of patients with age-related macular disease, diabetic retinopathy, and retinal detachments. The diagnosis is made with the most innovative devices, and the surgery is performed with the most advanced surgical instruments. Vitrectomy is performed on more than 700 cases/year with good outcomes. Hereditary retinal dystrophies and optic nerve diseases are also diagnosed and treated with many of the techniques developed in our department.

Our staff also includes skilled and experienced doctors who specialize in corneal diseases, glaucoma, pediatric ocular diseases including strabismus, uveal diseases, uveal diseases, ocular tumors, oculoplastic surgery, low vision, and other diseases and disorders of the eye.

Research Projects

A: Ophthalmic Imaging Research.
There have been significant improvements in the instruments used to obtain high resolution images of the eye. Different kinds of devices with new functions, such as scanning laser ophthalmoscopy (SLO), optical coherence tomography (OCT), adaptive optics (AO) fundus cameras, and wide-field fundus imaging systems have been incorporated into the standard clinical examinations. These new devices have allowed our clinicians to make new findings and more accurate diagnosis of new and older diseases.

The improvements of OCT have been especially rapid. It is now possible to detect finer details and subtler alterations in the deeper layers of the eye by the improvements in the resolution and changes in the wavelength of the examining light source. In addition, the introduction of OCT angiography has allowed clinicians to examine en face capillary networks at different depths in the retina noninvasively and without any dye injection. OCT angiography can detect subtle changes in the retinal capillary vessels that fluorescein angiography cannot detect.

Another new instrument that is available in our clinic is the adaptive optics fundus camera which allows clinicians to observe and study the mosaic arrangement of the photoreceptor cells in different kinds of retinal diseases.

With these examination procedures, new clinical research that can determine the pathogenesis of various kind of diseases has becomes possible. The progress in ophthalmic imaging device will continue, and the significance of these examinations in the clinics and research should make valuable contributions to the understanding of different disease processes. Importantly, the use of these instruments will allow our doctors to monitor noninvasively the effectiveness of the treatments prescribed.

B: Hereditary retinal diseases
Hereditary retinal diseases include a broad range of genetic disorders of the retina and choroid and are of varying severity and of different inheritance patterns. The treatment options are limited, and many researchers are investigating the underlying mechanisms causing the vision deficits while others are developing new treatments for the diseases.

Our department has a long history of research on hereditary retinal diseases, and more than 100 years ago, Dr. Chuta Oguchi, a former chairman of the Department of Ophthalmology of Nagoya Medical School, reported a new, distinctive type of retinal disease which is now called "Oguchi disease". Oguchi disease is characterized by the appearance of the fundus of the eye; under light-adapted conditions, the color of the fundus appears golden, and the appearance is normalized by dark-adaptation. This alteration of the appearance of the fundus is called the Mizuno-Nakamura phenomenon.

More recently, Dr. Yozo Miyake, another former chairman, discovered another new disease which he named occult macular dystrophy and is also called Miyake's disease.

The department has continued to carry this history of making new discoveries forward as we examine patients in the Tokai area of Japan using the most advanced instruments and with many techniques designed in our department.

The new findings are published in international journals concerned with hereditary retinal diseases, and this information is then made known worldwide.

We are also performing clinical and basic research on the pathophysiology of hereditary retinal diseases. The clinical research is based on retinal imaging, electrophysiological findings, and gene analyses. Our recent findings on occult macular dystrophy and Bestophinopathy have been recently published. Basic research was performed on a transgenic rabbit which is a model of human retinitis pigmentosa and was created in our department. Using this animal model, we have discovered the morphological and functional changes of the retina of this transgenic rabbit during the course of retinal degeneration. We found not only photoreceptor degeneration but also alterations of the inner retinal layers even though the mutated gene is related to a protein found in the photoreceptors. From the findings in this transgenic rabbit model, we aim to develop new treatments for retinitis pigmentosa.

We need to emphasize that our research has been supported by many patients, clinician, and several grants. We thank all who have participated in these research programs.

C: Retinal Blood Flow
Knowledge about the ocular blood flow in normal and diseased eyes is important for understanding pathological mechanisms and for determining the best treatment of various ocular diseases. For example, the blood flow has been reported to be reduced in some ocular diseases, e.g., AMD. We are investigating the blood flow in normal and diseased eyes using laser speckle flowgraphy (LSFG). It is well established that diurnal variations are present in various anatomic and physiological parameters of the eye, e.g., choroidal thickness and intraocular pressure. We have found significant diurnal variations in the blood flow on the optic nerve head (ONH) and choroid, and the blood flow is different on the ONH and choroid because of autoregulation (Medicine 2015).

We have analyzed a larger amount of data from the Nagoya University Hospital and the medical examinations made in Yakumo town. We have discovered that the blood flow velocity of the ONH was significantly higher in women than in men (Invest Ophthalmol Vis Sci, 2015).

Our results also show that the distribution of the erythrocytes, represented by the differences of the color and contrast density within the lumen, can be successfully evaluated by overlapping the LSFG images on the AO images. We found that the erythrocytes move faster in the retinal artery which has cell-free plasma layer close to the wall of the lumen (Medicine, 2015).

Our department has also conducted research on the complications of vitrectomy. Our results showed that some residual subretinal fluid remained beneath the fovea after surgery on eyes with macula-off rhegmatogenous retinal detachment (RRD) using an intraoperative OCT (Retina, 2016). In addition, we observed that the inner and outer segments of the photoreceptors were shortened immediately after the surgery, but they elongated with increasing postoperative time. The elongation of photoreceptor outer segments was significantly correlated with the improvement of the visual acuity (Invest Ophthalmol Vis Sci, 2016). Furthermore, the mean preoperative retinal blood flow determined by LSFG was significantly lower in eyes with RRD than in the fellow unaffected eyes, and a significant increase in the mean retinal blood flow was observed following successful attachment in eyes affected by RRD (Invest Ophthalmol Vis Sci, in press).

In eyes with proliferative diabetes retinopathy, we have found that intraoperative laser photocoagulation induced an increase in the peripheral retinochoroidal thickness compared to that before surgery. A choroidal detachment detected by anterior segment OCT, led to an approximately 10% reduction in the volume of vitreous cavity (Invest Ophthalmol Vis Sci, 2015).

In the future, we plan to investigate the relationship between ocular blood flow and chorioretinal diseases. We will use the new imaging devices on patients and experimental animals.

D: Clinical Goals and Translational Research

In the medical field, translational research is the application of the basic scientific research findings to the clinical situations. This should enhance the diagnosis and treatment of patients. Our Clinical and Translational Science (CTS) team will perform these researches, and our main targeted diseases are age-related macular degeneration (AMD), retinal detachment (RD)/proliferative vitreoretinopathy (PVR), diabetic retinopathy, and high myopia.

For example, our recent laboratory study showed that malondialdehyde (MDA), a lipid peroxidation byproduct, accumulated in the retinal pigment epithelium (RPE) of patients with AMD. The MDA induced autophagy and dysregulation of the RPE cells (Free Radic Biol Med, 2016). We also found that blue light emitting diodes (LEDs), an inducer of AMD, increased the level of reactive oxygen species (ROS) in the RPE cells, and Nrf2, an anti-oxidative factor, plays a role in protecting the cells from damage (Oxid Med Cell Longev, 2016).

In a study of eyes with a retinal detachment and proliferative vitreoretinopathy (RD/PVR), we detected a specific microRNA, miR148, in the vitreous fluid of patients with RD, and we showed that miR148 induced an epithelial-mesenchymal transition of RPE cells (Invest Ophthalmol Vis Sci, 2016). We are currently studying the clinical correlation in the miR148 expression level and the severity of the RD/PVR.

Our department is also studying different kinds of tissues that are collected during surgeries with approval of the Internal Review Board of the Nagoya Medical School. For example, we have re-examined the benefits and risks of peeling the internal limiting membrane (ILM) of the retina, a standard procedure used during vitreoretinal surgeries. More specifically, we are investigating the retinal structures and levels of the inflammatory cytokines in the vitreous fluid of patients before and after undergoing ILM peeling during intraocular surgery.

E: Clinical study of pediatric retinal diseases
Another group in our department is investigating patients with refractory pediatric retinal diseases including retinopathy of prematurity. Our team together with pediatrician and anesthesiologist has assessed the systemic condition of perioperative patients so that the patients are treated at the best time and under the best conditions to obtained favorable long-term results.

The use of anti-VEGF drugs to treat various retinal diseases has increased, and their administration has been examined in some of the pediatric diseases. More specifically, these assessments were made on children with retinopathy of prematurity to study the effects of the surgery. Our department has won the Pediatric Ophthalmology Society Award for 2016 for this study, and it has initiated an international clinical trial.

F: Macular group
The macula group has focused on macular diseases such as age-related macular degeneration, myopic choroidal neovascularization, central serous chorioretinopathy, and other macula-related diseases.

Age-related macular degeneration (AMD) is a leading cause of blindness in older individuals in developed countries. In Japan, 1% in people over 50-year-old are suffering from AMD, and although the use of intravitreal injections of anti-vascular endothelial growth factor (VEGF) agents has improved the visual acuity and prevented a worsening of the visual acuity, we cannot manage and treat AMD completely. Thus, the purpose of our current research program is to determine the mechanism of neovascularization using the findings obtained by optical coherent tomography (OCT) angiography.

G: Development of fiber-Optic OCT Probe for Intraocular Use
Optical coherence tomography (OCT) is an essential tool in the diagnosis and management of vitreoretinal diseases. The resolution of OCT instruments has greatly improved, and swept-source OCT (SS-OCT) has enabled clinicians to obtain images of the choroid and sclera. Vitreoretinal surgery has also improved with improved surgical instruments and operating microscopes. Despite these advances, surgeons occasionally need to make decisions during the course of intraoperative surgery. An intraocular OCT probe could help determine the optimal surgical course.

Currently, three types of intraoperative OCT instruments are used in vitreoretinal surgery: a hand-held, microscope-integrated, and a probe-type OCT. Our department and NIDEK Co. Ltd (Aichi, Japan) have successfully developed a fiber optic, 23-G, side-imaging SS-OCT probe that can be inserted through a 23-G trocar. This probe can provide high-quality images of ocular tissues, such as retinal tears, the internal limiting membrane (ILM), retinal detachments, and ciliary body, in animals and humans. We are currently trying to reduce the probe size, and improve the resolution of images toward commercialization.

These projects are supported by following groups.
"Program to Support Collaboration between Hospitals and Businesses for the Development and Improvement of Medical Equipment and Devices to Solve Unmet Medical Needs" of the Ministry of Economy, Trade and Industry
"Translational Research Network Program" of The Japan Agency for Medical Research and Development (AMED)

Faculty Members

Faculty	Position	Department
Koji Nishiguchi	Professor	Graduate School of Medicine and School of Medicine/ ophthalmology
Yasuki　Ito	Associate Professor	Graduate School of Medicine and School of Medicine/ ophthalmology
Shinji Ueno	Lecturer	University Hospital/ ophthalmology
Takeshi　Iwase	Lecturer	University Hospital/ ophthalmology
Yuko Iguchi	Assistant Professor	University Hospital/ ophthalmology
Hiroki Kaneko	Clinical Lecturer	University Hospital/ ophthalmology
Norie　Nonobe	Assistant　Clinical　Professor	University Hospital/ Maternal and Perinatal Care
Tetsuhiro　Yasuma	Assistant　Professor	Graduate School of Medicine and School of Medicine/ ophthalmology
Keiko Kataoka	Assistant　Professor	University Hospital/ ophthalmology
Shunsuke Yasuda	Assistant　Clinical Professor	University Hospital/ ophthalmology
Kei Takayama	Assistant　Clinical Professor	University Hospital/ ophthalmology

Bibliography

• 2016

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  2. Nagasaka Y, Ito Y, Ueno S, Terasaki H.Increased aqueous flare is associated with thickening of inner retinal layers in eyes with retinitis pigmentosa. Sci Rep, 2016; 6:33921.
  3. Fujinami K, Kameya S, Kikuchi S, Ueno S, Kondo M, Hayashi T, Shinoda K, Machida S, Kuniyoshi K, Kawamura Y, Akahori M, Yoshitake K, Katagiri S, Nakanishi A, Sakuramoto H, Ozawa Y, Tsubota K, Yamaki K, Mizota A, Terasaki H, Miyake Y, Iwata T, Tsunoda K.Novel RP1L1 Variants and Genotype-Photoreceptor Microstructural Phenotype Associations in Cohort of Japanese Patients With Occult Macular Dystrophy. Invest Ophthalmol Vis Sci, 2016; 57(11):4837-4846.
  4. Asami T, Terasaki H, Ito Y, Sugita T, Kaneko H, Nishiyama J, Namiki H, Kobayashi M, Nishizawa N. Development of a fiber-optic optical coherence tomography probe for intraocular use. Invest Ophthalmol Vis Sci, 2016; 57(9):OCT568-574.
  5. Iwase T, Yamamoto K, Yanagida K, Kobayashi M, Ra E, Murotani K, Terasaki H. Change in refraction after lens-sparing vitrectomy for rhegmatogenous retinal detachment and epiretinal membrane. Medicine (Baltimore), 2016; 95(32):e4317.
  6. Hasegawa T, Muraoka Y, Ikeda HO, Tsuruyama T, Kondo M, Terasaki H, Kakizuka A, Yoshimura N. Neuoroprotective efficacies by KUS121, a VCP modulator, on animal models of retinal degeneration. Sci Rep, 2016; 6:31184.
  7. Nakanishi A, Ueno S, Hayashi T, Katagiri S, Kominami T, Ito Y, Gekka T, Masuda Y, Tsuneoka H, Shinoda K, Hirakata A, Inoue M, Fujinami K, Tsunoda K, Iwata T, Terasaki H. Clinical and genetic findings of autosomal recessive bestrophinopathy in Japanese cohort. Am J Ophthalmol, 2016;168:86-94.
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  9. Takayama K, Kaneko H, Hwang SJ, Ye F, Higuchi A, Tsunekawa T, Matsuura T, Iwase T, Asami T, Ito Y, Ueno S, Yasuda S, Nonobe N, Terasaki H. Increased ocular levels of microRNA-148a in cases of retinal detachment promote epithelial- mesenchymal transition. Invest Ophthalmol Vis Sci, 2016;57(6):2699-2705.
  10. Nakanishi A, Ueno S, Hayashi T, Katagiri S, Kominami T, Ito Y, Gekka T, Masuda Y, Tsuneoka H, Shinoda K, Hirakata A, Inoue M, Fujinami K, Tsunoda K, Iwata T, Terasaki H. Clinical and genetic findings of autosomal recessive bestrophinopathy in Japanese cohort. Am J Ophthalmol, 2016;168:86-94.
  11. Kominami T, Ueno S, Nakanishi A, Kominami A, Kondo M, Furukawa T, Terasaki H. Temporal properties of cone ERGs of pikachurin null mutant mouse. Invest Ophthalmol Vis Sci, 2016;57(3):1264-1269.
  12. Kobayashi M, Iwase T, Yamamoto K, Ra E, Murotani K, Matsui S, Terasaki H. Association between photoreceptor regeneration and visual acuity following surgery for rhegmatogenous retinal detachment. Invest Ophthalmol Vis Sci, 2016;57(3):889-898.
  13. Ye F, Kaneko H, Hayashi Y, Takayama K, Hwang SJ, Nishizawa Y, Kimoto R, Nagasaka Y, Tsunekawa T, Matsuura T, Yasukawa T, Kondo T, Terasaki H. Malondialdehyde induces autophagy dysfunction and VEGF secretion in the retinal pigment epithelium in age-related macular degeneration. Free Radic Biol Med, 2016; 94:121-134.
  14. Bogdanovich S, Kim Y, Mizutani T, Yasuma R, Tudisco L, Cicatiello V, Bastos-Carvalho A, Kerur N, Hirano Y, Baffi JZ, Tarallo V, Li S, Yasuma T, Arpitha P, Fowler BJ, Wright CB, Apicella I, Greco A, Brunetti A, Ruvo M, Sandomenico A, Nozaki M, Ijima R, Kaneko H, Ogura Y, Terasaki H, Ambati BK, Leusen JH, Langdon WY, Clark MR, Armour KL, Bruhns P, Verbeek JS, Gelfand BD, De Falco S, Ambati J. Human IgG1 antibodies suppress angiogenesis in a target-independent manner. Signal Transduct Target Ther, 2016;1.
  15. Sato C, Kaneko H, Kondo T, Takayama K, Yasuda S, Terasaki H. Association of intraocular pressure changes with right ventricular diameter and brain natriuretic peptide in a case of pulmonary arterial hypertension. J Glaucoma, 2016;25(3):e295-298.
  16. Shirai H, Mandai M, Matsushita K, Kuwahara A, Yonemura S, Nakano T, Assawachananont J, Kimura T, Saito K, Terasaki H, Eiraku M, Sasai Y, Takahashi M. Transplantation of human embryonic stem cell-derived retinal tissue in two primate models of retinal degeneration. Proc Natl Acad Sci U S A, 2016;113(1):E81-90.
  17. Higashide T, Ohkubo S, Hangai M, Ito Y, Shimada N, Ohno-Matsui K, Terasaki H, Sugiyama K, Chew P, Li KK, Yoshimura N. Influence of clinical factors and magnification correction on normal thickness profiles of macular retinal layers using optical coherence tomography. PLoS One, 2016;11(1):e0147782.

• 2015

  1. Matsui A, Kaneko H, Kachi S, Ye F, Hwang SJ, Takayama K, Nagasaka Y, Sugita T, Terasaki H. Expression of vascular endothelial growth factor by retinal pigment epithelial cells induced by amyloid-β is depressed by an endoplasmic reticulum stress inhibitor. Ophthalmic Res, 2015;　55(1):37-44.
  2. Nakanishi A, Ueno S, Kawano K, Ito Y, Kominami T, Yasuda S, Kondo M, Tsunoda, K, Iwata T, Terasaki H. Pathologic changes of cone photoreceptors in eyes with occult macular dystrophy. Invest Ophthalmol Vis Sci, 2015;56(12):7243-7249.
  3. Futamura Y, Asami T, Nonobe N, Kachi S, Ito Y, Sato Y, Hayakawa M, Terasaki H. Buckling surgery and supplemental intravitreal bevacizumab or photocoagulation on stage 4 retinopathy of prematurity eyes. Jpn J Ophthalmol, 2015;59(6):378-388.
  4. Nakagami Y, Hatano E, Inoue T, Yoshida K, Kondo M, Terasaki H. Cytoprotective effects of a novel Nrf2 activator, RS9, in rhodopsin Pro347Leu rabbits. Curr Eye Res, 20152:1-4.
  5. Brown DM, Schmidt-Erfurth U, Do DV, Holz FG, Boyer DS, Midena E, Heier JS, Terasaki H, Kaiser PK, Marcus DM, Nguyen QD, Jaffe GJ, Slakter JS, Simader C, Soo Y, Schmelter T, Yancopoulos GD, Stahl N, Vitti R, Berliner AJ, Zeitz O, Metzig C,Korobelnik JF. Intravitreal aflibercept for diabetic macular edema: 100-week results from the VISTA and VIVID studies. Ophthalmology, 2015;122(10):2044-2052.
  6. Kaneko H, Ra E, Kawano K, Yasukawa T, Takayama K, Iwase T, Terasaki H. Surgical videos with synchronised vertical 2-split screens recording the surgeons' hand movement. Ophthalmologica, 2015;234(4):243-246.
  7. Yasuda S, Kachi S, Ueno S, Piao CH, Terasaki H. Flicker electroretinograms before and after intravitreal ranibizumab injection in eyes with central retinal vein occlusion. Acta Ophthalmol, 2015;93(6):e465-468.
  8. Sato Y, Oshiro M, Takemoto K, Hosono H, Saito A, Kondo T, Aizu K, Matsusawa M, Futamura Y, Asami T, Terasaki H, Hayakawa M. Multicenter observational study comparing sedation/ analgesia protocols for laser photocoagulation treatment of retinopathy of prematurity. J Perinatol, 2015;35(9):965-969.
  9. Iwase T, Ra E, Yamamoto K, Kaneko H, Ito Y, Terasaki H. Differences of retinal blood flow between arteries and veins determined by laser speckle flowgraphy in healthy subjects. Medicine (Baltimore), 2015;94(33):e1256.
  10. Ueno S, Kawano K, Ito Y, Ra E, Nakanishi A, Nagaya M, Terasaki H. Near-infrared reflectance imaging in eyes with acute zonal occult outer retinopathy. Retina, 2015;35(8):1521-1530.
  11. Gomi F, Oshima Y, Mori R, Kano M, Saito M, Yamashita A, Iwata E, Maruko R; Fujisan Study Group. Initial versus delayed photodynamic therapy in combination with anibizumab for treatment of polypoidal choroidal vasculopathy: The Fujisan Study. Retina, 2015;35(8):1569-1576.
  12. Asakawa K, Ishikawa H, Uga S, Mashimo K, Shimizu K, Kondo M, Terasaki H. Functional and morphological study of retinal photoreceptor cell degeneration in transgenic rabbits with a Pro347Leu rhodopsin mutation. Jpn J Ophthalmol, 2015;59(5):353-363.
  13. Yanagida K, Iwase T, Yamamoto K, Ra E, Kaneko H, Murotani K, Matsui S, Terasaki H. Sex-related differences in ocular blood flow of healthy subjects using laser speckle flowgraphy. Invest Ophthalmol Vis Sci, 2015;56(8):4880-4890.
  14. Yasuda S, Kachi S, Kondo M, Ueno S, Kaneko H, Terasaki H. Significant correlation between retinal venous tortuosity and aqueous vascular endothelial growth factor concentration in eyes with central retinal vein occlusion. PLoS One, 2015;10(7):e0134267.
  15. Nagaya M, Ueno S, Kominami T, Nakanishi A, Koyasu T, Kondo M, Furukawa T, Terasaki H. Pikachurin protein required for increase of cone electroretinogram b-wave during light adaptation. PLoS One, 2015;10(6):e0128921.
  16. Yamamoto K, Iwase T, Ushida H, Sugita T, Terasaki H. Changes in retinochoroidal thickness after vitrectomy for proliferative diabetic retinopathy. Invest Ophthalmol Vis Sci, 2015;56(5):3034-3040.
  17. Kataoka K, Matsumoto H, Kaneko H, Notomi S, Takeuchi K, Sweigard JH, Atik A, Murakami Y, Connor KM, Terasaki H, Miller JW, Vavvas DG. Macrophage- and RIP3-dependent inflammasome activation exacerbates retinal detachment-induced photoreceptor cell death. Cell Death Dis, 2015;6:e1731.
  18. Ijima R, Kaneko H, Ye F, Takayama K, Nagasaka Y, Kataoka K, Funahashi Y, Iwase T, Kachi S, Kato S, Terasaki H. Suppression of laser-induced choroidal neovascularization by the oral medicine targeting histamine receptor H4 in mice. Transl Vis Sci Technol, 2015;4(2):6.
  19. Iwase T, Yamamoto K, Ra E, Murotani K, Matsui S, Terasaki H. Diurnal variations in blood flow at optic nerve head and choroid in healthy eyes: diurnal variations in blood flow. Medicine (Baltimore), 2015;94(6):e519.
  20. Asami T, Kachi S, Mohamed UA, Ito Y, Terasaki H. High osmolarity effect of intravitreal plasmin enzyme on rabbit retina. Nagoya J Med Sci, 2015;77(1-2):245-252.
  21. Ueno S, Nakanishi A, Nishi K, Suzuki S, Terasaki H. Case of paraneoplastic retinopathy with retinal ON-bipolar cell dysfunction and subsequent resolution of ERGs. Doc Ophthalmol, 2015; 130(1):71-76.
  22. Kuniyoshi K, Terasaki H, Arai M, Hirose T. Macular electroretinogram in stargardt's disease/fundus flavimaculatus. Ophthalmologica, 2015;233(2):113-114.
  23. Ogura Y, Terasaki H, Gomi F, Yuzawa M, Iida T, Honda M, Nishijo K, Sowade O, Komori T, Schmidt-Erfurth U, Simader C, Chong V; for the VIEW 2 Investigators. Efficacy and safety of intravitreal aflibercept injection in wet age-related macular degeneration: outcomes in the Japanese subgroup of the VIEW2 study. Br J Ophthalmol, 2015;99(1):92-97.
  24. Ye F, Kaneko H, Nagasaka Y, Ijima R, Nakamura K, Nagaya M, Takayama K, Kajiyama H, Senga T, Tanaka H, Mizuno M, Kikkawa F, Hori M, Terasaki H. Plasma-activated medium suppresses choroidal neovascularization in mice: a new therapeutic concept for age-related macular degeneration. Sci Rep, 2015;5:7705.

• 2014

  1. Ueno S, Ito Y, Maruko R, Kondo M, Terasaki H. Choroidal atrophy in a patient with paraneoplastic retinopathy and anti-TRPM1 antibody. Clin Ophthalmol, 2014;8:369-373.
  2. Kaneko H, Ye F, Ijima R, Kachi S, Kato S, Nagaya M, Higuchi A, Terasaki H. Histamine receptor h4 as a new therapeutic target for choroidal neovascularization in age-related macular degeneration. Br J Pharmacol, 2014; 171:3754-3763.
  3. Hirano Y, Yasuma T, Mizutani T, Fowler B, Tarallo V, Yasuma R, Kim Y, Carvalho AB, Kerur N, Gelfand B, He S, Zhang X, Nozaki M, Ijima R, Kaneko H, Ogura Y, Terasaki H, Nunez G, Ambati B, Hinton D, Nagai H, Haro I, Ambati J: IL18 is not therapeutic for neovascular age-related macular degeneration. Nat Med, 2014;20(12): 1372-1375.
  4. Korobelnik JF, Do DV, Schmidt-Erfurth U, Boyer DS, Holz FG, Heier JS, Midena E, Kaiser PK, Terasaki H, Marcus DM, Nguyen QD, Jaffe GJ, Slakter JS, Simader C, Soo Y, Schmelter T, Yancopoulos GD, Stahl N, Vitti R, Berliner AJ, Zeitz O, Metzig C, Brown DM. Intravitreal Aflibercept for Diabetic Macular Edema. Ophthalmology, 2014;121(11):2247-2254.
  5. Ijima R, Kaneko H, Ye F, Nagasaka Y, Takayama K, Kataoka K, Kachi S, Iwase T, Terasaki H. Interleukin-18 induces retinal pigment epithelium degeneration in mice. Invest Ophthalmol Vis Sci, 2014;55(10):6673-6678.
  6. Zhao Y, Hosono K, Suto K, Ishigami C, Arai Y, Hikoya A, Hirami Y, Ohtsubo M, Ueno S, Terasaki H, Sato M, Nakanishi H, Endo S, Mizuta K, Mineta H, Kondo M, Takahashi M, Minoshima S, Hotta Y. The first USH2A mutation analysis of Japanese autosomal recessive retinitis pigmentosa patients: a totally different mutation profile with the lack of frequent mutations found in Caucasian patients. J Hum Genet, 2014;59(9):521-528.
  7. Shen J, Choy DF, Yoshida T, Iwase T, Hafiz G, Xie B, Hackett SF, Arron JR,　Campochiaro PA. Interleukin-18 has antipermeablity and antiangiogenic activities in the eye: reciprocal suppression with VEGF. J Cell Physiol, 2014;229(8):974-983.
  8. Asami T, Terasaki H. Development of caliper for scleral measurements during scleral buckling surgery. Retina, 2014;34(8):1713-1714.
  9. Iwase T, Oveson BC. Long-term outcome after vitrectomy for macular edema with retinal vein occlusion dividing into the occlusion site. J Ophthalmol, 2014:198782.
  10. Matsui Y, Matsubara H, Ueno S, Ito Y, Terasaki H, Kondo M. Changes in outer retinal microstructures during six month period in eyes with acute zonal occult outer retinopathy-complex. PLoS One, 2014; 9(10):e110592.
  11. Ogura Y, Roider J, Korobelnik JF, Holz FG, Simader C, Schmidt-Erfurth U, Vitti R, Berliner AJ, Hiemeyer F, Stemper B, Zeitz O, Sandbrink R; GALILEO Study Group;GALILEO Study Group. Intravitreal aflibercept for macular edema secondary to central retinal vein occlusion: 18-month results of the phase 3 GALILEO study. Am J Ophthalmol, 2014;158(5):1032-1038.e2.
  12. Iwase T, Oveson BC, Jo YJ. Clear corneal vitrectomy combined with phacoemulsification and foldable intraocular lens implantation. Clin Experiment Ophthalmol, 2014;42(5):452-458.
  13. Iguchi Y, Asami T, Ueno S, Ushida H, Maruko R, Oiwa K, Terasaki H. Changes in vitreous temperature during intravitreal surgery. Invest Ophthalmol Vis Sci, 2014;55(4):2344-2349.

Research Keywords

Terasaki Hiroko、Yozo Miyake、Chuta Oguchi、age-related macular disease、Hereditary retinal diseases、SS-OCT、retinopathy of prematurity

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