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Clinical NeurosciencesPsychiatry

Introduction

The basic policy of our department is to take into account the needs of patients and their families, while promoting "the solution of daily clinical problems" and aiming to "elucidate the causes and mechanisms of diseases and, on this basis, to develop diagnostic methods, treatments and preventive measures". To achieve this goal, it is essential that clinical and basic research progress in close collaboration.

In our department, we conduct comprehensive research on various mental disorders, including schizophrenia, depression, bipolar disorder, dementia and autism spectrum disorder, from a bio-psycho-social perspective, focusing on diagnosis, treatment methods and understanding of their causes and mechanisms.

Research Projects

Genomeic research
  • The genome research team conducts research into the pathophysiology of psychiatric disorders and pharmacogenomics using various genomic analysis techniques. In particular, we conduct genome-wide association studies (GWAS) and whole-genome sequencing (WGS) to develop new diagnostic and treatment response prediction methods for psychiatric disorders. We also conduct clinical research based on these findings and collaborate with basic researchers to explore the causes and mechanisms of these disorders.
  • In psychiatric disorders, we use telomere-to-telomere (T2T) long-read sequencing technology to detect variants across the entire genome. This includes regions that have previously been difficult to decipher, providing a comprehensive analysis of genetic variants associated with disease risk.
Psychotherapy
  • We practise psychodynamic psychiatry and liaison psychiatry. We are investigating psychosocial factors associated with depression and anxiety in cancer patients and organ transplant recipients, with the aim of early identification and intervention. We also focus on chronic pain patients in the dental field, working to elucidate the pathophysiology of stress-related disorders and develop treatments through psychosocial assessment.
Clinical pharmacology and epidemiology
  • We conduct clinical and epidemiological research into the efficacy, safety and appropriate use of various psychotropic medicines. In addition to clinical trials, we emphasise clinical perspectives in our research, generating new evidence by using real-world data.
  • We are investigating disease markers based on physiological information such as EEG, EMG, sleep patterns and mental state, and exploring the potential for clinical and home testing through the validation of advanced wearable devices.
Neuropathology / Geriatric Psychiatry
  • We have established the Nagoya Brain Bank Consortium to elucidate the pathological background of psychiatric symptoms. We carry out comprehensive analysis of human brain tissue, from schizophrenia to neurodegenerative diseases. The psychiatric brain bank, which is rare even globally, is essential for understanding disease mechanisms. In clinical research, we focus on psychiatric symptoms in the prodromal phase of dementia and search for diagnostic biomarkers such as neuroimaging in late-onset psychiatric disorders, with a focus on early diagnosis of Lewy body dementia.
Child and Adolescent Psychiatry
  • In the paediatrics group, we conduct genetic and clinical research on neurodevelopmental disorders and are involved in research related to training in paediatric psychiatry (the clinical area of child mental health) as a subspecialty of both psychiatry and paediatrics. We are also involved in the development and operation of a paediatric psychiatry training programme in Mongolia.
Neuroimaging
  • We conduct research using MRI to elucidate the pathophysiology of psychiatric disorders and to aid diagnosis, assess treatment response and predict prognosis. We also investigate the relationship between brain structure and function, cognitive function and clinical data such as eye movements.
Psychopathology
  • We are researching the psychopathology and psychotherapy of psychiatric disorders in general, including disorders at the periphery of social withdrawal, and conducting clinical case conferences through descriptive case reports. We also research the dissemination of treatment guidelines for psychiatric disorders.
Perinatal Research
  • Pregnant and postpartum women are particularly vulnerable to depression, which affects their health and the care of their children. We are conducting a genomic cohort study using epigenomic and AI analyses to investigate the genetic and environmental factors associated with maternal depression.
Basic research
  • We use model cells and animals of psychiatric disorders based on risk variants for disease onset to conduct drug discovery research. We also aim to understand disease mechanisms and develop treatments using iPS cells derived from patients with psychiatric disorders.

Faculty Members

FacultyPositionDepartment
Masashi Ikeda Professor Graduate School of Medicine Program in Integrated Medicine Clinical Neurosciences
Norio Ozaki Designated professor Graduate School of Medicine
Hiroshige Fujishiro Designated professor Graduate School of Medicine Department of Clinical Psychiatry
Hiroyuki Kimura Associate professor Graduate School of Medicine Program in Integrated Medicine
Branko Aleksic Designated associate professor Administrative Support Organizations International Education & Exchange
Kunihiro Iwamoto Associate professor Graduate School of Medicine Program in Integrated Medicine
Hiroki Kimura Lecturer Graduate School of Medicine Program in Integrated Medicine Clinical Neurosciences
Itaru Kushima Lecturer Nagoya University Hospital Medical Genomics Center
Youta Torii Lecturer Nagoya University Hospital Center for Postgraduate Clinical Training and Career Development
Maeri Yamamoto Lecturer Nagoya University Hospital Psychiatry
Hidekazu Kato Designated Lecture Graduate School of Medicine Department of Clinical Psychiatry
Kazuyoshi Ogasawara Assistant professor of hospital Nagoya University Hospital Center for Postgraduate Clinical Training and Career Development
Masako Tachibana Assistant Professor Nagoya University Hospital Psychiatry
Yoshihiro Nawa Assistant professor Nagoya University Hospital Psychiatry for Parents and Children
Kuniyuki Iwata Assistant Professor Nagoya University Hospital Psychiatry for Parents and Children
Shusei Arafuka Assistant Professor Nagoya University Hospital Clinical Oncology and Chemotherapy
Kazuhiro Takeda Assistant Professor Nagoya University Hospital Psychiatry
Yu Hayashi Designated Assistant Professor Graduate School of Medicine Department of developmental disability medicine
Daisuke Mori Designated associate professor Brain and Mind Research Center Division
Seiko Miyata Designated Lecture Graduate School of Medicine Department of Clinical Psychiatry
Yuko Arioka Designated Lecture Nagoya University Hospital Center for Advanced Medicine and Clinical Research
Hiroki Okumura Designated Assistant Professor Graduate School of Medicine

Bibliography

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    8. Furukawa S, Kushima I, Aleksic B and Ozaki N. Case reports of two siblings with autism spectrum disorder and 15q13.3 deletions. Neuropsychopharmacol Rep 2023; 43: 462-466. 20230601. DOI: 10.1002/npr2.12340.
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    12. Herrera-Rivero M, Gutiérrez-Fragoso K, Thalamuthu A, Amare AT, Adli M, Akiyama K, Akula N, Ardau R, Arias B, Aubry JM, Backlund L, Bellivier F, Benabarre A, Bengesser S, Abesh B, Biernacka J, Birner A, Cearns M, Cervantes P, Chen HC, Chillotti C, Cichon S, Clark S, Colom F, Cruceanu C, Czerski P, Dalkner N, Degenhardt F, Del Zompo M, DePaulo JR, Etain B, Falkai P, Ferensztajn-Rochowiak E, Forstner AJ, Frank J, Frisen L, Frye M, Fullerton J, Gallo C, Gard S, Garnham J, Goes F, Grigoroiu-Serbanescu M, Grof P, Hashimoto R, Hasler R, Hauser J, Heilbronner U, Herms S, Hoffmann P, Hou L, Hsu Y, Jamain S, Jiménez E, Kahn JP, Kassem L, Kato T, Kelsoe J, Kittel-Schneider S, Kuo PH, Kurtz J, Kusumi I, König B, Laje G, Landén M, Lavebratt C, Leboyer M, Leckband S, Maj M, Manchia M, Marie-Claire C, Martinsson L, McCarthy M, McElroy SL, Millischer V, Mitjans M, Mondimore F, Monteleone P, Nievergelt C, Novak T, Nöthen M, Odonovan C, Ozaki N, Papiol S, Pfennig A, Pisanu C, Potash J, Reif A, Reininghaus E, Richard-Lepouriel H, Roberts G, Rouleau G, Rybakowski JK, Schalling M, Schofield P, Schubert KO, Schulte E, Schweizer B, Severino G, Shekhtman T, Shilling P, Shimoda K, Simhandl C, Slaney C, Squassina A, Stamm T, Stopkova P, Streit F, Ayele F, Tortorella A, Turecki G, Veeh J, Vieta E, Viswanath B, Witt S, Zandi P, Alda M, Bauer M, McMahon F, Mitchell P, Rietschel M, Schulze T and Baune B. Immunogenetics of lithium response and psychiatric phenotypes in patients with bipolar disorder. Res Sq 2023 20230626. DOI: 10.21203/rs.3.rs-3068352/v1.
    13. Iida H, Okada T, Nemoto K, Hasegawa N, Numata S, Ogasawara K, Miura K, Matsumoto J, Hori H, Iga JI, Ichihashi K, Hashimoto N, Yamada H, Ohi K, Yasui-Furukori N, Fukumoto K, Tsuboi T, Usami M, Furihata R, Takaesu Y, Hishimoto A, Muraoka H, Katsumoto E, Nagasawa T, Ochi S, Komatsu H, Kikuchi S, Takeshima M, Onitsuka T, Tamai S, Kubota C, Inada K, Watanabe K, Kawasaki H and Hashimoto R. Satisfaction with web-based courses on clinical practice guidelines for psychiatrists: Findings from the \"effectiveness of guidelines for dissemination and education in psychiatric treatment (eguide)\" project. Neuropsychopharmacol Rep 2023; 43: 23-32. 20221128. DOI: 10.1002/npr2.12300.
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    17. Kato S, Maesawa S, Bagarinao E, Nakatsubo D, Tsugawa T, Mizuno S, Kawabata K, Tsuboi T, Suzuki M, Shibata M, Takai S, Ishizaki T, Torii J, Mutoh M, Saito R, Wakabayashi T, Katsuno M, Ozaki N, Watanabe H and Sobue G. Magnetic resonance-guided focused ultrasound thalamotomy restored distinctive resting-state networks in patients with essential tremor. J Neurosurg 2023; 138: 306-317. 20220708. DOI: 10.3171/2022.5.Jns22411.
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    19. Kawai K, Iwamoto K, Miyata S, Okada I, Fujishiro H, Noda A, Nakagome K, Ozaki N and Ikeda M. Comparison of polysomnography, single-channel electroencephalogram, fitbit, and sleep logs in patients with psychiatric disorders: Cross-sectional study. J Med Internet Res 2023; 25: e51336. 20231213. DOI: 10.2196/51336.
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    21. Kimura H, Kishi S, Narita H, Tanaka T, Okada T, Fujisawa D, Sugita N, Noma S, Matsumoto Y, Ohashi A, Mitsuyasu H, Yoshida K, Kawasaki H, Nishimura K, Ogura Y and Ozaki N. Comorbid psychiatric disorders and long-term survival after liver transplantation in transplant facilities with a psychiatric consultation-liaison team: A multicenter retrospective study. BMC Gastroenterol 2023; 23: 106. 20230405. DOI: 10.1186/s12876-023-02735-1.
    22. Kimura H, Kushima I, Banno M, Inada T, Yoshimi A, Aleksic B and Ozaki N. Clinical characterization of patients with schizophrenia and 16p13.11 duplication: A case series. Neuropsychopharmacol Rep 2023; 43: 267-271. 20230428. DOI: 10.1002/npr2.12334.
    23. Kubota C, Inada T, Lin SK, Avasthi A, Chee KY, Tanra AJ, Yang SY, Chen LY, Chong MY, Tripathi A, Kallivayalil RA, Grover S, Park SC, Kato TA, Xiang YT, Sim K, Maramis MM, Noor IM, Tan CH, Sartorius N and Shinfuku N. The factor structure of extrapyramidal symptoms evaluated using the drug-induced extrapyramidal symptoms scale in patients with schizophrenia: Results from the 2016 reap ap-4 study. Hum Psychopharmacol 2023; 38: e2861. 20221203. DOI: 10.1002/hup.2861.
    24. Liao J, Dong G, Zhu W, Wulaer B, Mizoguchi H, Sawahata M, Liu Y, Kaibuchi K, Ozaki N, Nabeshima T, Nagai T and Yamada K. Rho kinase inhibitors ameliorate cognitive impairment in a male mouse model of methamphetamine-induced schizophrenia. Pharmacol Res 2023; 194: 106838. 20230628. DOI: 10.1016/j.phrs.2023.106838.
    25. Lo T, Kushima I, Aleksic B, Yoshimi A, Someya T, Watanabe Y and Ozaki N. Clinical manifestations of schizophrenia in four patients with variants in voltage-gated calcium channel-encoding genes: A case series. Psychiatry Clin Neurosci 2023; 77: 57-59. 20221109. DOI: 10.1111/pcn.13494.
    26. Lo T, Kushima I, Kimura H, Aleksic B, Okada T, Kato H, Inada T, Nawa Y, Torii Y, Yamamoto M, Kimura R, Funabiki Y, Kosaka H, Numata S, Kasai K, Sasaki T, Yokoyama S, Munesue T, Hashimoto R, Yasuda Y, Fujimoto M, Usami M, Itokawa M, Arai M, Ohi K, Someya T, Watanabe Y, Egawa J, Takahashi T, Suzuki M, Yamasue H, Iwata N, Ikeda M and Ozaki N. Association between copy number variations in parkin (prkn) and schizophrenia and autism spectrum disorder: A case-control study. Neuropsychopharmacol Rep 2024; 44: 42-50. 20231101. DOI: 10.1002/npr2.12370.
    27. Matsumoto J, Fukunaga M, Miura K, Nemoto K, Okada N, Hashimoto N, Morita K, Koshiyama D, Ohi K, Takahashi T, Koeda M, Yamamori H, Fujimoto M, Yasuda Y, Ito S, Yamazaki R, Hasegawa N, Narita H, Yokoyama S, Mishima R, Miyata J, Kobayashi Y, Sasabayashi D, Harada K, Yamamoto M, Hirano Y, Itahashi T, Nakataki M, Hashimoto RI, Tha KK, Koike S, Matsubara T, Okada G, Yoshimura R, Abe O, van Erp TGM, Turner JA, Jahanshad N, Thompson PM, Onitsuka T, Watanabe Y, Matsuo K, Yamasue H, Okamoto Y, Suzuki M, Ozaki N, Kasai K and Hashimoto R. Cerebral cortical structural alteration patterns across four major psychiatric disorders in 5549 individuals. Mol Psychiatry 2023; 28: 4915-4923. 20230818. DOI: 10.1038/s41380-023-02224-7.
    28. Miyake N, Tsurusaki Y, Fukai R, Kushima I, Okamoto N, Ohashi K, Nakamura K, Hashimoto R, Hiraki Y, Son S, Kato M, Sakai Y, Osaka H, Deguchi K, Matsuishi T, Takeshita S, Fattal-Valevski A, Ekhilevitch N, Tohyama J, Yap P, Keng WT, Kobayashi H, Takubo K, Okada T, Saitoh S, Yasuda Y, Murai T, Nakamura K, Ohga S, Matsumoto A, Inoue K, Saikusa T, Hershkovitz T, Kobayashi Y, Morikawa M, Ito A, Hara T, Uno Y, Seiwa C, Ishizuka K, Shirahata E, Fujita A, Koshimizu E, Miyatake S, Takata A, Mizuguchi T, Ozaki N and Matsumoto N. Molecular diagnosis of 405 individuals with autism spectrum disorder. Eur J Hum Genet 2024; 32: 1551-1558. 20230327. DOI: 10.1038/s41431-023-01335-7.
    29. Miyata S, Iwamoto K and Ozaki N. Evaluating sleep-wake rhythm using a wearable device in patients with mental disorders. Psychiatry Clin Neurosci 2023; 77: 419. 20230628. DOI: 10.1111/pcn.13568.
    30. Mizutani R, Saiga R, Yamamoto Y, Uesugi M, Takeuchi A, Uesugi K, Terada Y, Suzuki Y, De Andrade V, De Carlo F, Takekoshi S, Inomoto C, Nakamura N, Torii Y, Kushima I, Iritani S, Ozaki N, Oshima K, Itokawa M and Arai M. Structural aging of human neurons is opposite of the changes in schizophrenia. PLoS One 2023; 18: e0287646. 20230623. DOI: 10.1371/journal.pone.0287646.
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    33. Ohgidani M, Kushima I, Inamine S, Kyuragi S, Sagata N, Nakao T, Kanba S, Ozaki N and Kato TA. A case of bipolar disorder with aif1 (coding gene of iba-1) deletion: A pilot in vitro analysis using blood-derived microglia-like cells. Psychiatry Clin Neurosci 2023; 77: 128-130. 20221124. DOI: 10.1111/pcn.13505.
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    39. Sato-Boku A, Tokura T, Kimura H, Ito M, Kishi S, Tonoike T, Ozaki N, Nakano Y, Hosijima H and Tachi N. The usefulness of the short form-8 for chronic pain in the orofacial region: A prospective cohort study. Cureus 2023; 15: e45586. 20230920. DOI: 10.7759/cureus.45586.
    40. Senica N, Aleksic B, Inada T, Iljes AP, Zamuda T and Kumperscak HG. Slovenian version of the drug-induced extrapyramidal symptoms scale: Evaluation of interrater and test-retest reliability. J Clin Psychopharmacol 2023; 43: 361-364. 20230501. DOI: 10.1097/jcp.0000000000001682.
    41. Shimamoto M, Ishizuka K, Ohtani K, Inada T, Yamamoto M, Tachibana M, Kimura H, Sakai Y, Kobayashi K, Ozaki N and Ikeda M. Machine learning algorithm-based estimation model for the severity of depression assessed using montgomery-asberg depression rating scale. Neuropsychopharmacol Rep 2024; 44: 115-120. 20231220. DOI: 10.1002/npr2.12404.
    42. Suzuki K, Nishio N, Kimura H, Tokura T, Kishi S, Ozaki N, Fujimoto Y and Sone M. Comparison of quality of life and psychological distress in patients with tongue cancer undergoing a total/subtotal glossectomy or extended hemiglossectomy and free flap transfer: A prospective evaluation. Int J Oral Maxillofac Surg 2023; 52: 621-629. 20221202. DOI: 10.1016/j.ijom.2022.11.010.
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  • 2022
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    69. Sato A, Kimura H, Tokura T, Umemura E, Miyauchi T, Ito M, Kishi S, Ogi N, Tonoike T, Ozaki N, Nakano Y, Okuda M. Evaluation of patients suffered from burning mouth syndrome and persistent idiopathic facial pain using japanese version paindetect questionnaire and depression scales. Journal of Dental Sciences. 2021;16(1):131-136.
    71. Sato M, Okada T, Morikawa M, Nakamura Y, Yamauchi A, Ando M, Ozaki N. Validation and factor analysis of the parental bonding instrument in japanese pregnant women. Scientific Reports. 2021;11(1):1-10.
    73. Schubert KO, Thalamuthu A, Amare AT, Frank J, Streit F, Adl M, Akula N, Akiyama K, Ardau R, Arias B, Aubry JM, Backlund L, Bhattacharjee AK, Bellivier F, Benabarre A, Bengesser S, Biernacka JM, Birner A, Marie-Claire C, Cearns M, Cervantes P, Chen HC, Chillotti C, Cichon S, Clark SR, Cruceanu C, Czerski PM, Dalkner N, Dayer A, Degenhardt F, Del Zompo M, DePaulo JR, Etain B, Falkai P, Forstner AJ, Frisen L, Frye MA, Fullerton JM, Gard S, Garnham JS, Goes FS, Grigoroiu-Serbanescu M, Grof P, Hashimoto R, Hauser J, Heilbronner U, Herms S, Hoffmann P, Hou LP, Hsu YH, Jamain S, Jimenez E, Kahn JP, Kassem L, Kuo PH, Kato T, Kelsoe J, Kittel-Schneider S, Ferensztajn-Rochowiak E, Konig B, Kusumi I, Laje G, Landen M, Lavebratt C, Leboyer M, Leckband SG, Maj M, Manchia M, Martinsson L, McCarthy MJ, McElroy S, Colom F, Mitjans M, Mondimore FM, Monteleone P, Nievergelt CM, Nothen MM, Novak T, O'Donovan C, Ozaki N, Osby U, Papiol S, Pfennig A, Pisanu C, Potash JB, Reif A, Reininghaus E, Rouleau GA, Rybakowski JK, Schalling M, Schofield PR, Schweizer BW, Severino G, Shekhtman T, Shilling PD, Shimoda K, Simhandl C, Slaney CM, Squassina A, Stamm T, Stopkova P, Tekola-Ayele F, Tortorella A, Turecki G, Veeh J, Vieta E, Witt SH, Roberts G, Zandi PP, Alda M, Bauer M, McMahon FJ, Mitchell PB, Schulze TG, Rietschel M, Baune BT, Psychiat Genomics C. Combining schizophrenia and depression polygenic risk scores improves the genetic prediction of lithium response in bipolar disorder patients. Translational Psychiatry. 2021;11(1):1-8.
    75. Sekiguchi H, Fujishiro H, Torii Y, Iritani S, Ozaki N. Can we identify prodromal dementia with lewy bodies in late-life depression? Psychiatry and Clinical Neurosciences. 2021;75(3):113-114.
    77. Shizuku M, Kimura H, Kamei H, Kishi S, Tokura T, Kurata N, Jobara K, Yoshizawa A, Tsuboi C, Yamaguchi N, Kato M, Kawai K, Yamashiki M, Kanai E, Ishizuka K, Ozaki N, Ogura Y. Psychosocial characteristics of alcoholic and non-alcoholic liver disease recipient candidates in liver transplantation: A prospective observational study. Bmc Gastroenterology. 2021;21(1):1-10.
    79. Stone W, Nunes A, Akiyama K, Akula N, Ardau R, Aubry JM, Backlund L, Bauer M, Bellivier F, Cervantes P, Chen HC, Chillotti C, Cruceanu C, Dayer A, Degenhardt F, Del Zompo M, Forstner AJ, Frye M, Fullerton JM, Grigoroiu-Serbanescu M, Grof P, Hashimoto R, Hou LP, Jimenez E, Kato T, Kelsoe J, Kittel-Schneider S, Kuo PH, Kusumi I, Lavebratt C, Manchia M, Martinsson L, Mattheisen M, McMahon FJ, Millischer V, Mitchell PB, Nothen MM, O'Donovan C, Ozaki N, Pisanu C, Reif A, Rietschel M, Rouleau G, Rybakowski J, Schalling M, Schofield PR, Schulze TG, Severino G, Squassina A, Veeh J, Vieta E, Trappenberg T, Alda M. Prediction of lithium response using genomic data. Scientific Reports. 2021;11(1):1-10.
    81. Tachibana M, Inada T, Ichida M, Kojima S, Arai T, Naito K, Ozaki N. Significant decrease in delirium referrals after changing hypnotic from benzodiazepine to suvorexant. Psychogeriatrics. 2021;21(3):324-332.
    83. Tachibana M, Inada T, Ichida M, Kojima S, Shioya M, Wakayama K, Ozaki N. Factors associated with the severity of delirium. Human Psychopharmacology-Clinical and Experimental. 2021;36(5):e2787.
    85. Tachibana M, Inada T, Ichida M, Ozaki N. Risk factors for inducing violence in patients with delirium. Brain and Behavior. 2021;11(8):e2276.
    87. Tachibana M, Inada T, Ichida M, Ozaki N. Factors affecting hallucinations in patients with delirium. Scientific Reports. 2021;11(1):1-6.
    89. Takahashi N, Okumura A, Nishimura T, Harada T, Iwabuchi T, Rahman MS, Tsuchiya KJ. Exploration of Sleep Parameters, Daytime Hyperactivity/Inattention, and Attention-Deficit/Hyperactivity Disorder Polygenic Risk Scores of Children in a Birth Cohort in Japan. JAMA Netw Open. 2022;5:e2141768.
    91. Takahashi N, Nishimura T, Harada T, Okumura A, Iwabuchi T, Rahman MS, Kuwabara H, Takagai S, Nomura Y, Takei N, Tsuchiya KJ. Association Between Genetic Risks for Obesity and Working Memory in Children. Front Neurosci. 2021;15:749230.
    93. Takahashi N, Ishizuka K, Inada T. Peripheral biomarkers of attention-deficit hyperactivity disorder: Current status and future perspective. J Psychiatr Res. 2021;137:465-70.
    95. Tsuneura Y, Sawahata M, Itoh N, Miyajima R, Mori D, Kohno T, Hattori M, Sobue A, Nagai T, Mizoguchi H, Nabeshima T, Ozaki N, Yamada K. Analysis of reelin signaling and neurodevelopmental trajectory in primary cultured cortical neurons with reln deletion identified in schizophrenia. Neurochemistry International. 2021;144:104954.
    97. Uchida M, Noda Y, Hasegawa S, Hida H, Taniguchi M, Mouri A, Yoshimi A, Nabeshima T, Yamada K, Aida T, Tanaka K, Ozaki N. Early postnatal inhibition of glast causes abnormalities of psychobehaviors and neuronal morphology in adult mice. Neurochemistry International. 2021;150:105177.
    99. Yoshikawa A, Kushima I, Miyashita M, Toriumi K, Suzuki K, Horiuchi Y, Kawaji H, Takizawa S, Ozaki N, Itokawa M, Arai M. Dysregulation of post-transcriptional modification by copy number variable micrornas in schizophrenia with enhanced glycation stress. Translational Psychiatry. 2021;11(1):1-11.
  • 2021
    1. Amare AT, Schubert KO, Hou L, Clark SR, Papiol S, Cearns M, Heilbronner U, Degenhardt F, Tekola-Ayele F, Hsu YH, Shekhtman T, Adli M, Akula N, Akiyama K, Ardau R, Arias B, Aubry JM, Backlund L, Bhattacharjee AK, Bellivier F, Benabarre A, Bengesser S, Biernacka JM, Birner A, Brichant-Petitjean C, Cervantes P, Chen HC, Chillotti C, Cichon S, Cruceanu C, Czerski PM, Dalkner N, Dayer A, Del Zompo M, DePaulo JR, Étain B, Jamain S, Falkai P, Forstner AJ, Frisen L, Frye MA, Fullerton JM, Gard S, Garnham JS, Goes FS, Grigoroiu-Serbanescu M, Grof P, Hashimoto R, Hauser J, Herms S, Hoffmann P, Hofmann A, Jiménez E, Kahn JP, Kassem L, Kuo PH, Kato T, Kelsoe JR, Kittel-Schneider S, Kliwicki S, König B, Kusumi I, Laje G, Landén M, Lavebratt C, Leboyer M, Leckband SG, Tortorella A, Manchia M, Martinsson L, McCarthy MJ, McElroy SL, Colom F, Mitjans M, Mondimore FM, Monteleone P, Nievergelt CM, Nöthen MM, Novák T, O'Donovan C, Ozaki N, Ösby U, Pfennig A, Potash JB, Reif A, Reininghaus E, Rouleau GA, Rybakowski JK, Schalling M, Schofield PR, Schweizer BW, Severino G, Shilling PD, Shimoda K, Simhandl C, Slaney CM, Squassina A, Stamm T, Stopkova P, Maj M, Turecki G, Vieta E, Veeh J, Witt SH, Wright A, Zandi PP, Mitchell PB, Bauer M, Alda M, Rietschel M, McMahon FJ, Schulze TG, Baune BT. Association of polygenic score for major depression with response to lithium in patients with bipolar disorder. Molecular psychiatry. 2020. https://doi.org/10.1038/s41380-020-0689-5
    3. Arioka Y, Hirata A, Kushima I, Aleksic B, Mori D, Ozaki N. Characterization of a schizophrenia patient with a rare reln deletion by combining genomic and patient-derived cell analyses. Schizophrenia research. 2020;216:511-5.
    5. Arioka Y, Shishido E, Kushima I, Mori D, Ozaki N. Cell body shape and directional movement stability in human-induced pluripotent stem cell-derived dopaminergic neurons. Scientific reports. 2020;10(1):5820.
    7. Bagarinao E, Watanabe H, Maesawa S, Mori D, Hara K, Kawabata K, Ohdake R, Masuda M, Ogura A, Kato T, Koyama S, Katsuno M, Wakabayashi T, Kuzuya M, Hoshiyama M, Isoda H, Naganawa S, Ozaki N, Sobue G. Identifying the brain's connector hubs at the voxel level using functional connectivity overlap ratio. NeuroImage. 2020;222:117241.
    9. Bagarinao E, Watanabe H, Maesawa S, Mori D, Hara K, Kawabata K, Yoneyama N, Ohdake R, Imai K, Masuda M, Yokoi T, Ogura A, Taoka T, Koyama S, Tanabe HC, Katsuno M, Wakabayashi T, Kuzuya M, Hoshiyama M, Isoda H, Naganawa S, Ozaki N, Sobue G. Aging impacts the overall connectivity strength of regions critical for information transfer among brain networks. Frontiers in aging neuroscience. 2020;12:592469.
    11. Choy SW, Bagarinao E, Watanabe H, Ho ETW, Maesawa S, Mori D, Hara K, Kawabata K, Yoneyama N, Ohdake R, Imai K, Masuda M, Yokoi T, Ogura A, Taoka T, Koyama S, Tanabe HC, Katsuno M, Wakabayashi T, Kuzuya M, Hoshiyama M, Isoda H, Naganawa S, Ozaki N, Sobue G. Changes in white matter fiber density and morphology across the adult lifespan: A cross-sectional fixel-based analysis. Human brain mapping. 2020;41(12):3198-211.
    13. Ishizuka K, Yoshida T, Kawabata T, Imai A, Mori H, Kimura H, Inada T, Okahisa Y, Egawa J, Usami M, Kushima I, Morikawa M, Okada T, Ikeda M, Branko A, Mori D, Someya T, Iwata N, Ozaki N. Functional characterization of rare nrxn1 variants identified in autism spectrum disorders and schizophrenia. Journal of neurodevelopmental disorders. 2020;12(1):25.
    15. Ito T, Hiramatsu Y, Uchida M, Yoshimi A, Mamiya T, Mouri A, Ozaki N, Noda Y. Involvement of protein kinase c beta1-serotonin transporter system dysfunction in emotional behaviors in stressed mice. Neurochemistry international. 2020;140:104826.
    17. Ito Y, Maesawa S, Bagarinao E, Okai Y, Nakatsubo D, Yamamoto H, Kidokoro H, Usui N, Natsume J, Hoshiyama M, Wakabayashi T, Sobue G, Ozaki N. Subsecond eeg-fmri analysis for presurgical evaluation in focal epilepsy. Journal of neurosurgery. 2020:1-10.
    19. Itokawa M, Oshima K, Arai M, Torii Y, Kushima I, Iritani S, Ozaki N, Saiga R, Mizutani R. Cutting-edge morphological studies of post-mortem brains of patients with schizophrenia and potential applications of x-ray nanotomography (nano-ct). Psychiatry and clinical neurosciences. 2020;74(3):176-82.
    21. Kato K, Noda A, Yasuma F, Matsubara Y, Miyata S, Iwamoto K, Miyazaki S, Ozaki N. Effects of sleep-disordered breathing and hypertension on cognitive function in elderly adults. Clinical and experimental hypertension (New York, NY : 1993). 2020;42(3):250-6.
    23. Kato S, Bagarinao E, Isoda H, Koyama S, Watanabe H, Maesawa S, Mori D, Hara K, Katsuno M, Hoshiyama M, Naganawa S, Ozaki N, Sobue G. Effects of head motion on the evaluation of age-related brain network changes using resting state functional mri. Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine. 2020.
    25. Kimura H, Mori D, Aleksic B, Ozaki N. Elucidation of molecular pathogenesis and drug development for psychiatric disorders from rare disease-susceptibility variants. Neuroscience research. 2020.
    27. Koshiyama D, Fukunaga M, Okada N, Morita K, Nemoto K, Usui K, Yamamori H, Yasuda Y, Fujimoto M, Kudo N, Azechi H, Watanabe Y, Hashimoto N, Narita H, Kusumi I, Ohi K, Shimada T, Kataoka Y, Yamamoto M, Ozaki N, Okada G, Okamoto Y, Harada K, Matsuo K, Yamasue H, Abe O, Hashimoto R, Takahashi T, Hori T, Nakataki M, Onitsuka T, Holleran L, Jahanshad N, van Erp TGM, Turner J, Donohoe G, Thompson PM, Kasai K, Hashimoto R. White matter microstructural alterations across four major psychiatric disorders: Mega-analysis study in 2937 individuals. Molecular psychiatry. 2020;25(4):883-95.
    29. Kubota C, Inada T, Nakamura Y, Shiino T, Ando M, Aleksic B, Yamauchi A, Morikawa M, Okada T, Ohara M, Sato M, Murase S, Goto S, Kanai A, Ozaki N. Validation and factor structure of the japanese version of the inventory to diagnose depression, lifetime version for pregnant women. PloS one. 2020;15(6):e0234240.
    31. Kubota C, Inada T, Shiino T, Ando M, Sato M, Nakamura Y, Yamauchi A, Morikawa M, Okada T, Ohara M, Aleksic B, Murase S, Goto S, Kanai A, Ozaki N. The risk factors predicting suicidal ideation among perinatal women in japan. Frontiers in psychiatry. 2020;11:441.
    33. Lim ET, Uddin M, De Rubeis S, Chan Y, Kamumbu AS, Zhang X, D'Gama AM, Kim SN, Hill RS, Goldberg AP, Poultney C, Minshew NJ, Kushima I, Aleksic B, Ozaki N, Parellada M, Arango C, Penzol MJ, Carracedo A, Kolevzon A, Hultman CM, Weiss LA, Fromer M, Chiocchetti AG, Freitag CM, Church GM, Scherer SW, Buxbaum JD, Walsh CA. Publisher correction: Rates, distribution and implications of postzygotic mosaic mutations in autism spectrum disorder. Nature neuroscience. 2020;23(9):1176.
    35. Miyata S, Iwamoto K, Banno M, Eguchi J, Kaneko S, Noda A, Ozaki N. Performance of an ambulatory electroencephalogram sleep monitor in patients with psychiatric disorders. Journal of sleep research. 2020:e13273.
    37. Miyata S, Otake H, Ando M, Okuda M, Fujishiro H, Iwamoto K, Noda A, Sone M, Ozaki N. Patient characteristics affecting accurate detection of sleep apnea using a bed sheet-type portable monitor. Sleep & breathing = Schlaf & Atmung. 2020;24(2):783-90.
    39. Mukoyama N, Nishio N, Kimura H, Kishi S, Tokura T, Kimura H, Hiramatsu M, Maruo T, Tsuzuki H, Fujii M, Iwami K, Takanari K, Kamei Y, Ozaki N, Sone M, Fujimoto Y. Prospective evaluation of health-related quality of life in patients undergoing anterolateral craniofacial resection with orbital exenteration. Journal of neurological surgery Part B, Skull base. 2020;81(5):585-93.
    41. Nakamura Y, Okada T, Morikawa M, Yamauchi A, Sato M, Ando M, Ozaki N. Perinatal depression and anxiety of primipara is higher than that of multipara in japanese women. Scientific reports. 2020;10(1):17060.
    43. Noda Y, Uchida M, Mouri A, Yamada S, Goto S, Kitagaki S, Mamiya T, Kushima I, Arioka Y, Ozaki N, Yoshimi A. Involvement of nicotinic acetylcholine receptors in behavioral abnormalities and psychological dependence in schizophrenia-like model mice. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. 2020;41:92-105.
    45. Saito R, Koebis M, Nagai T, Shimizu K, Liao J, Wulaer B, Sugaya Y, Nagahama K, Uesaka N, Kushima I, Mori D, Maruyama K, Nakao K, Kurihara H, Yamada K, Kano M, Fukada Y, Ozaki N, Aiba A. Comprehensive analysis of a novel mouse model of the 22q11.2 deletion syndrome: A model with the most common 3.0-mb deletion at the human 22q11.2 locus. Translational psychiatry. 2020;10(1):35.
    47. Sakurai M, Yamamoto Y, Kanayama N, Hasegawa M, Mouri A, Takemura M, Matsunami H, Miyauchi T, Tokura T, Kimura H, Ito M, Umemura E, Boku AS, Nagashima W, Tonoike T, Kurita K, Ozaki N, Nabeshima T, Saito K. Serum metabolic profiles of the tryptophan-kynurenine pathway in the high risk subjects of major depressive disorder. Scientific reports. 2020;10(1):1961.
    49. Sawahata M, Mori D, Arioka Y, Kubo H, Kushima I, Kitagawa K, Sobue A, Shishido E, Sekiguchi M, Kodama A, Ikeda R, Aleksic B, Kimura H, Ishizuka K, Nagai T, Kaibuchi K, Nabeshima T, Yamada K, Ozaki N. Generation and analysis of novel reln-deleted mouse model corresponding to exonic reln deletion in schizophrenia. Psychiatry and clinical neurosciences. 2020;74(5):318-27.
    51. Sekiguchi M, Sobue A, Kushima I, Wang C, Arioka Y, Kato H, Kodama A, Kubo H, Ito N, Sawahata M, Hada K, Ikeda R, Shinno M, Mizukoshi C, Tsujimura K, Yoshimi A, Ishizuka K, Takasaki Y, Kimura H, Xing J, Yu Y, Yamamoto M, Okada T, Shishido E, Inada T, Nakatochi M, Takano T, Kuroda K, Amano M, Aleksic B, Yamomoto T, Sakuma T, Aida T, Tanaka K, Hashimoto R, Arai M, Ikeda M, Iwata N, Shimamura T, Nagai T, Nabeshima T, Kaibuchi K, Yamada K, Mori D, Ozaki N. Arhgap10, which encodes rho gtpase-activating protein 10, is a novel gene for schizophrenia risk. Translational psychiatry. 2020;10(1):247.
    53. Shizuku M, Kamei H, Kimura H, Kurata N, Jobara K, Yoshizawa A, Ishizuka K, Okada A, Kishi S, Ozaki N, Ogura Y. Clinical features and long-term outcomes of living donors of liver transplantation who developed psychiatric disorders. Annals of transplantation. 2020;25:e918500.
    55. Suzuki T, Suzuki T, Raveau M, Miyake N, Sudo G, Tsurusaki Y, Watanabe T, Sugaya Y, Tatsukawa T, Mazaki E, Shimohata A, Kushima I, Aleksic B, Shiino T, Toyota T, Iwayama Y, Nakaoka K, Ohmori I, Sasaki A, Watanabe K, Hirose S, Kaneko S, Inoue Y, Yoshikawa T, Ozaki N, Kano M, Shimoji T, Matsumoto N, Yamakawa K. A recurrent pja1 variant in trigonocephaly and neurodevelopmental disorders. Annals of clinical and translational neurology. 2020;7(7):1117-31.
    57. Taniguchi S, Ninomiya K, Kushima I, Saito T, Shimasaki A, Sakusabe T, Momozawa Y, Kubo M, Kamatani Y, Ozaki N, Ikeda M, Iwata N. Polygenic risk scores in schizophrenia with clinically significant copy number variants. Psychiatry and clinical neurosciences. 2020;74(1):35-9.
    59. Torii Y, Iritani S, Marui T, Sekiguchi H, Habuchi C, Fujishiro H, Kushima I, Oshima K, Niizato K, Hayashida S, Masaki K, Kira JI, Yoshida M, Ozaki N. Morphological alteration of myelin-oligodendrocytes in a schizophrenic patient with 22q11.2 deletion syndrome: An autopsy study. Schizophrenia research. 2020;223:353-5.
    61. Torii Y, Iritani S, Sekiguchi H, Habuchi C, Fujishiro H, Kushima I, Kawakami I, Itokawa M, Arai M, Hayashida S, Masaki K, Kira JI, Kawashima K, Ozaki N. The accumulation of advanced glycation end-products in a schizophrenic patient with a glyoxalase 1 frameshift mutation: An autopsy study. Schizophrenia research. 2020;223:356-8.
    63. Yamamoto M, Bagarinao E, Kushima I, Takahashi T, Sasabayashi D, Inada T, Suzuki M, Iidaka T, Ozaki N. Support vector machine-based classification of schizophrenia patients and healthy controls using structural magnetic resonance imaging from two independent sites. PloS one. 2020;15(11):e0239615.
    65. Yamasue H, Okada T, Munesue T, Kuroda M, Fujioka T, Uno Y, Matsumoto K, Kuwabara H, Mori D, Okamoto Y, Yoshimura Y, Kawakubo Y, Arioka Y, Kojima M, Yuhi T, Owada K, Yassin W, Kushima I, Benner S, Ogawa N, Eriguchi Y, Kawano N, Uemura Y, Yamamoto M, Kano Y, Kasai K, Higashida H, Ozaki N, Kosaka H. Effect of intranasal oxytocin on the core social symptoms of autism spectrum disorder: A randomized clinical trial. Molecular psychiatry. 2020;25(8):1849-58.
    67. Yu Y, Chaulagain A, Pedersen SA, Lydersen S, Leventhal BL, Szatmari P, Aleksic B, Ozaki N, Skokauskas N. Pharmacotherapy of restricted/repetitive behavior in autism spectrum disorder:A systematic review and meta-analysis. BMC psychiatry. 2020;20(1):121.
    69. Yuka K, Nishizawa D, Hasegawa J, Uno K, Miyanishi H, Ujike H, Ozaki N, Inada T, Iwata N, Sora I, Iyo M, Yamada M, Kondo N, Won MJ, Naruse N, Uehara-Aoyama K, Ikeda K, Nitta A. A single medical marker for diagnosis of methamphetamine addiction - DNA methylation of shati/nat8l promoter sites from patient blood. Current pharmaceutical design. 2020;26(2):260-4.
  • 2020
    1. Baba M, Yokoyama K, Seiriki K, Naka Y, Matsumura K, Kondo M, Yamamoto K, Hayashida M, Kasai A, Ago Y, Nagayasu K, Hayata-Takano A, Takahashi A, Yamaguchi S, Mori D, Ozaki N, Yamamoto T, Takuma K, Hashimoto R, Hashimoto H, Nakazawa T. Psychiatric-disorder-related behavioral phenotypes and cortical hyperactivity in a mouse model of 3q29 deletion syndrome. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2019;44(12):2125-35.
    3. Bagarinao E, Watanabe H, Maesawa S, Mori D, Hara K, Kawabata K, Yoneyama N, Ohdake R, Imai K, Masuda M, Yokoi T, Ogura A, Taoka T, Koyama S, Tanabe HC, Katsuno M, Wakabayashi T, Kuzuya M, Ozaki N, Hoshiyama M, Isoda H, Naganawa S, Sobue G. Reorganization of brain networks and its association with general cognitive performance over the adult lifespan. Scientific reports. 2019;9(1):11352.
    5. Fujishiro H, Kimura H, Nakamura T, Torii Y, Iritani S, Ozaki N. Hypochondriasis in the elderly and lewy body disease. Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society. 2019;19(5):516-8.
    7. Fujishiro H, Okuda M, Iwamoto K, Miyata S, Torii Y, Iritani S, Ozaki N. Clinical profiles of late-onset psychiatric patients exhibiting incidental rem sleep without atonia. Journal of neural transmission (Vienna, Austria : 1996). 2019;126(8):1095-104.
    9. Hasegawa S, Yoshimi A, Mouri A, Uchida Y, Hida H, Mishina M, Yamada K, Ozaki N, Nabeshima T, Noda Y. Acute administration of ketamine attenuates the impairment of social behaviors induced by social defeat stress exposure as juveniles via activation of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (ampa) receptors. Neuropharmacology. 2019;148:107-16.
    11. Hayakawa N, Tanaka S, Hirata N, Ogino S, Ozaki N. A battery of self-screening instruments and self-reported body frame could not detect eating disorders among college students. BMC research notes. 2019;12(1):613.
    13. Hirano M, Iritani S, Fujishiro H, Torii Y, Habuchi C, Sekiguchi H, Yoshida M, Ozaki N. Clinicopathological differences between the motor onset and psychiatric onset of huntington's disease, focusing on the nucleus accumbens. Neuropathology : official journal of the Japanese Society of Neuropathology. 2019;39(5):331-41.
    15. Ikeda M, Takahashi A, Kamatani Y, Momozawa Y, Saito T, Kondo K, Shimasaki A, Kawase K, Sakusabe T, Iwayama Y, Toyota T, Wakuda T, Kikuchi M, Kanahara N, Yamamori H, Yasuda Y, Watanabe Y, Hoya S, Aleksic B, Kushima I, Arai H, Takaki M, Hattori K, Kunugi H, Okahisa Y, Ohnuma T, Ozaki N, Someya T, Hashimoto R, Yoshikawa T, Kubo M, Iwata N. Genome-wide association study detected novel susceptibility genes for schizophrenia and shared trans-populations/diseases genetic effect. Schizophrenia bulletin. 2019;45(4):824-34.
    17. Ishii T, Ishikawa M, Fujimori K, Maeda T, Kushima I, Arioka Y, Mori D, Nakatake Y, Yamagata B, Nio S, Kato TA, Yang N, Wernig M, Kanba S, Mimura M, Ozaki N, Okano H. In vitro modeling of the bipolar disorder and schizophrenia using patient-derived induced pluripotent stem cells with copy number variations of pcdh15 and reln. eNeuro. 2019;6(5).
    19. Iwata M, Iwamoto K, Omura T, Ando M, Ozaki N. Protocol for the development and validation of a driving simulator for evaluating the influence of drugs on driving performance. Medicine. 2019;98(8):e14613.
    21. Kato H, Ozaki N. [the considerations for diagnosis of autism spectrum disorders and its pathogenic mechanisms]. Rinsho shinkeigaku = Clinical neurology. 2019;59(1):13-20.
    23. Kawakubo H, Matsui Y, Kushima I, Ozaki N, Shimamura T. A network of networks approach for modeling interconnected brain tissue-specific networks. Bioinformatics (Oxford, England). 2019;35(17):3092-101.
    25. Kubota C, Inada T, Shiino T, Ando M, Aleksic B, Yamauchi A, Sato M, Ohara M, Murase S, Morikawa M, Nakamura Y, Okada T, Goto S, Kanai A, Ozaki N. Relation between perinatal depressive symptoms, harm avoidance, and a history of major depressive disorder: A cohort study of pregnant women in japan. Frontiers in psychiatry. 2019;10:515.
    27. Matsubara T, Hayashi K, Wakatsuki K, Abe M, Ozaki N, Yamanaka A, Mizumura K, Taguchi T. Thin-fibre receptors expressing acid-sensing ion channel 3 contribute to muscular mechanical hypersensitivity after exercise. European journal of pain (London, England). 2019;23(10):1801-13.
    29. Miyata S, Noda A, Kawai S, Honda K, Iwamoto K, Ozaki N, Miyazaki S, Kondo T. Delayed sleep/wake rhythm and excessive daytime sleepiness correlate with decreased daytime brain activity during cognitive task in university students. Biological and rhythm research, 2019; 50(2)：171-179.
    30. Miyauchi T, Tokura T, Kimura H, Ito M, Umemura E, Sato Boku A, Nagashima W, Tonoike T, Yamamoto Y, Saito K, Kurita K, Ozaki N. Effect of antidepressant treatment on plasma levels of neuroinflammation-associated molecules in patients with somatic symptom disorder with predominant pain around the orofacial region. Human psychopharmacology. 2019;34(4):e2698.
    32. Mizutani R, Saiga R, Takeuchi A, Uesugi K, Terada Y, Suzuki Y, De Andrade V, De Carlo F, Takekoshi S, Inomoto C, Nakamura N, Kushima I, Iritani S, Ozaki N, Ide S, Ikeda K, Oshima K, Itokawa M, Arai M. Three-dimensional alteration of neurites in schizophrenia. Translational psychiatry. 2019;9(1):85.
    34. Nakamura Y, Nakatochi M, Kunimoto S, Okada T, Aleksic B, Toyama M, Shiino T, Morikawa M, Yamauchi A, Yoshimi A, Furukawa-Hibi Y, Nagai T, Ohara M, Kubota C, Yamada K, Ando M, Ozaki N. Methylation analysis for postpartum depression: A case control study. BMC psychiatry. 2019;19(1):190.
    36. Noda A, Yasuma F, Miyata S, Iwamoto K, Yasuda Y, Ozaki N. Sleep fragmentation and risk of automobile accidents in patients with obstructive sleep apnea. Health 2019; 11(2): 171-181.
    38. Owada K, Okada T, Munesue T, Kuroda M, Fujioka T, Uno Y, Matsumoto K, Kuwabara H, Mori D, Okamoto Y, Yoshimura Y, Kawakubo Y, Arioka Y, Kojima M, Yuhi T, Yassin W, Kushima I, Benner S, Ogawa N, Kawano N, Eriguchi Y, Uemura Y, Yamamoto M, Kano Y, Kasai K, Higashida H, Ozaki N, Kosaka H, Yamasue H. Quantitative facial expression analysis revealed the efficacy and time course of oxytocin in autism. Brain : a journal of neurology. 2019;142(7):2127-36.
    40. Park SC, Oh HS, Tripathi A, Kallivayalil RA, Avasthi A, Grover S, Tanra AJ, Kanba S, Kato TA, Inada T, Chee KY, Chong MY, Lin SK, Sim K, Xiang YT, Tan CH, Javed A, Sartorius N, Shinfuku N, Park YC. Cannabis use correlates with aggressive behavior and long-acting injectable antipsychotic treatment in asian patients with schizophrenia. Nordic journal of psychiatry. 2019;73(6):323-30.
    42. Sato N, Kimura H, Adachi Y, Nishio N, Ando M, Tokura T, Nagashima W, Kishi S, Yamauchi A, Yoshida K, Hiramatsu M, Fujimoto Y, Ozaki N. Exploration of coping styles in male patients with head and neck cancer: A prospective cohort study. Nagoya journal of medical science. 2019;81(2):249-58.
    44. Shishido E, Ogawa S, Miyata S, Yamamoto M, Inada T, Ozaki N. Application of eye trackers for understanding mental disorders: Cases for schizophrenia and autism spectrum disorder. Neuropsychopharmacology reports. 2019;39(2):72-7.
    46. Takeuchi S, Hida H, Uchida M, Naruse R, Yoshimi A, Kitagaki S, Ozaki N, Noda Y. Blonanserin ameliorates social deficit through dopamine-d3 receptor antagonism in mice administered phencyclidine as an animal model of schizophrenia. Neurochemistry international. 2019;128:127-34.
    48. Tanaka S, Oya-Ito T, Murakami Y, Saito K, Furuta S, Yu Y, Imaeda M, Kunimoto S, Ozaki N. Decline of plasma concentrations of interleukin-18 in severely malnourished patients with anorexia nervosa: Exploratory analysis. Nutrients. 2019;11(3).
    50. Teshigawara T, Mouri A, Kubo H, Nakamura Y, Shiino T, Okada T, Morikawa M, Nabeshima T, Ozaki N, Yamamoto Y, Saito K. Changes in tryptophan metabolism during pregnancy and postpartum periods: Potential involvement in postpartum depressive symptoms. Journal of affective disorders. 2019;255:168-76.
    52. Uchida M, Hida H, Mori K, Yoshimi A, Kitagaki S, Yamada K, Hiraoka Y, Aida T, Tanaka K, Ozaki N, Noda Y. Erratum to \"functional roles of the glial glutamate transporter (glast) in emotional and cognitive abnormalities of mice after repeated phencyclidine administration\" [european neuropsychopharmacology (2019) 29, 914-924]. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. 2019;29(9):1063-4.
    54. Uchida M, Hida H, Mori K, Yoshimi A, Kitagaki S, Yamada K, Hiraoka Y, Aida T, Tanaka K, Ozaki N, Noda Y. Functional roles of the glial glutamate transporter (glast) in emotional and cognitive abnormalities of mice after repeated phencyclidine administration. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. 2019;29(8):914-24.
    56. Ueda K, Kiyota A, Tsuchida M, Okazaki M, Ozaki N. Successful treatment of myxedema coma with a combination of levothyroxine and liothyronine. Endocrine journal. 2019;66(5):469-74.
    58. Umemura E, Tokura T, Ito M, Kobayashi Y, Tachibana M, Miyauchi T, Tonoike T, Nagashima W, Kimura H, Arao M, Sato Boku A, Ozaki N, Kurita K. Oral medicine psychiatric liaison clinic: Study of 1202 patients attending over an 18-year period. International journal of oral and maxillofacial surgery. 2019;48(5):644-50.
    60. Weidle B, Chaulagain A, Stensen K, Aleksic B, Skokauskas N, Inada T. Drug-induced extrapyramidal symptoms scale of the norwegian version: Inter-rater and test-retest reliability. Nordic journal of psychiatry. 2019;73(8):546-50.
    62. Yoshimi A, Yamada S, Kunimoto S, Aleksic B, Hirakawa A, Ohashi M, Matsumoto Y, Hada K, Itoh N, Arioka Y, Kimura H, Kushima I, Nakamura Y, Shiino T, Mori D, Tanaka S, Hamada S, Noda Y, Nagai T, Yamada K, Ozaki N. Author correction: Proteomic analysis of lymphoblastoid cell lines from schizophrenic patients. Translational psychiatry. 2019;9(1):146.
    64. Yoshimi A, Yamada S, Kunimoto S, Aleksic B, Hirakawa A, Ohashi M, Matsumoto Y, Hada K, Itoh N, Arioka Y, Kimura H, Kushima I, Nakamura Y, Shiino T, Mori D, Tanaka S, Hamada S, Noda Y, Nagai T, Yamada K, Ozaki N. Proteomic analysis of lymphoblastoid cell lines from schizophrenic patients. Translational psychiatry. 2019;9(1):126.
    66. Arioka Y, Hirata A, Kushima I, Aleksic B, Mori D, Ozaki N. Characterization of a schizophrenia patient with a rare reln deletion by combining genomic and patient-derived cell analyses. Schizophrenia research. 2019. In press.
    68. Miyata S, Otake H, Ando M, Okuda M, Fujishiro H, Iwamoto K, Noda A, Sone M, Ozaki N. Patient characteristics affecting accurate detection of sleep apnea using a bed sheet-type portable monitor. Sleep & breathing. 2019. In Press.
    70. Mukoyama N, Nishio N, Kimura H, Kishi S, Tokura T, Kimura H, Hiramatsu M, Maruo T, Tsuzuki H, Fujii M, Iwami K, Takanari K, Kamei Y, Ozaki N, Sone M, Fujimoto Y. Prospective evaluation of health-related quality of life in patients undergoing anterolateral craniofacial resection with orbital exenteration. Journal of Neurological Surgery Part B, 2019. In Press.
  • 2019
    1. Amare AT, Schubert KO, Hou L, Clark SR, Papiol S, Heilbronner U, Degenhardt F, Tekola-Ayele F, Hsu YH, Shekhtman T, Adli M, Akula N, Akiyama K, Ardau R, Arias B, Aubry JM, Backlund L, Bhattacharjee AK, Bellivier F, Benabarre A, Bengesser S, Biernacka JM, Birner A, Brichant-Petitjean C, Cervantes P, Chen HC, Chillotti C, Cichon S, Cruceanu C, Czerski PM, Dalkner N, Dayer A, Del Zompo M, DePaulo JR, Etain B, Falkai P, Forstner AJ, Frisen L, Frye MA, Fullerton JM, Gard S, Garnham JS, Goes FS, Grigoroiu-Serbanescu M, Grof P, Hashimoto R, Hauser J, Herms S, Hoffmann P, Hofmann A, Jamain S, Jimenez E, Kahn JP, Kassem L, Kuo PH, Kato T, Kelsoe J, Kittel-Schneider S, Kliwicki S, Konig B, Kusumi I, Laje G, Landen M, Lavebratt C, Leboyer M, Leckband SG, Tortorella A, Manchia M, Martinsson L, McCarthy MJ, McElroy S, Colom F, Mitjans M, Mondimore FM, Monteleone P, Nievergelt CM, Nothen MM, Novak T, O'Donovan C, Ozaki N, Osby U, Pfennig A, Potash JB, Reif A, Reininghaus E, Rouleau GA, Rybakowski JK, Schalling M, Schofield PR, Schweizer BW, Severino G, Shilling PD, Shimoda K, Simhandl C, Slaney CM, Squassina A, Stamm T, Stopkova P, Maj M, Turecki G, Vieta E, Volkert J, Witt S, Wright A, Zandi PP, Mitchell PB, Bauer M, Alda M, Rietschel M, McMahon FJ, Schulze TG, Baune BT. Association of polygenic score for schizophrenia and hla antigen and inflammation genes with response to lithium in bipolar affective disorder: A genome-wide association study. JAMA psychiatry. 2018;75(1):65-74.
    3. Arioka Y, Kushima I, Kubo H, Mori D, Ozaki N. Induced pluripotent stem cells derived from a schizophrenia patient with astn2 deletion. Stem cell research. 2018;30:81-4.
    5. Arioka Y, Kushima I, Mori D, Ozaki N. Three lines of induced pluripotent stem cells derived from a 15q11.2-q13.1 duplication syndrome patient. Stem cell research. 2018;31:240-3.
    7. Arioka Y, Shishido E, Kubo H, Kushima I, Yoshimi A, Kimura H, Ishizuka K, Aleksic B, Maeda T, Ishikawa M, Kuzumaki N, Okano H, Mori D, Ozaki N. Single-cell trajectory analysis of human homogenous neurons carrying a rare reln variant. Translational psychiatry. 2018;8(1):129.
    9. Bagarinao E, Watanabe H, Maesawa S, Mori D, Hara K, Kawabata K, Yoneyama N, Ohdake R, Imai K, Masuda M, Yokoi T, Ogura A, Wakabayashi T, Kuzuya M, Ozaki N, Hoshiyama M, Isoda H, Naganawa S, Sobue G. An unbiased data-driven age-related structural brain parcellation for the identification of intrinsic brain volume changes over the adult lifespan. NeuroImage. 2018;169:134-44.
    11. Fujishiro H, Okuda M, Iwamoto K, Miyata S, Torii Y, Iritani S, Ozaki N. Early diagnosis of lewy body disease in patients with late-onset psychiatric disorders using clinical history of rapid eye movement sleep behavior disorder and [(123) i]-metaiodobenzylguanidine cardiac scintigraphy. Psychiatry and clinical neurosciences. 2018;72(6):423-34.
    13. Hasegawa S, Miyake Y, Yoshimi A, Mouri A, Hida H, Yamada K, Ozaki N, Nabeshima T, Noda Y. Dysfunction of serotonergic and dopaminergic neuronal systems in the antidepressant-resistant impairment of social behaviors induced by social defeat stress exposure as juveniles. The international journal of neuropsychopharmacology. 2018;21(9):837-46.
    15. Ikeda M, Takahashi A, Kamatani Y, Momozawa Y, Saito T, Kondo K, Shimasaki A, Kawase K, Sakusabe T, Iwayama Y, Toyota T, Wakuda T, Kikuchi M, Kanahara N, Yamamori H, Yasuda Y, Watanabe Y, Hoya S, Aleksic B, Kushima I, Arai H, Takaki M, Hattori K, Kunugi H, Okahisa Y, Ohnuma T, Ozaki N, Someya T, Hashimoto R, Yoshikawa T, Kubo M, Iwata N. Genome-wide association study detected novel susceptibility genes for schizophrenia and shared trans-populations/diseases genetic effect. Schizophrenia bulletin. 2018.
    17. Ikeda M, Tanaka S, Saito T, Ozaki N, Kamatani Y, Iwata N. Re-evaluating classical body type theories: Genetic correlation between psychiatric disorders and body mass index. Psychological medicine. 2018;48(10):1745-8.
    19. Iritani S, Habuchi C, Sekiguchi H, Torii Y. Brain research and clinical psychiatry: Establishment of a psychiatry brain bank in japan. Nagoya journal of medical science. 2018;80(3):309-15.
    21. Iritani S, Torii Y, Habuchi C, Sekiguchi H, Fujishiro H, Yoshida M, Go Y, Iriki A, Isoda M, Ozaki N. The neuropathological investigation of the brain in a monkey model of autism spectrum disorder with abca13 deletion. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. 2018;71:130-9.
    23. Ishizuka K, Kimura H, Kushima I, Inada T, Okahisa Y, Ikeda M, Iwata N, Mori D, Aleksic B, Ozaki N. Assessment of a glyoxalase i frameshift variant, p.P122fs, in japanese patients with schizophrenia. Psychiatric genetics. 2018;28(5):90-3.
    25. Ishizuka K, Tabata H, Ito H, Kushima I, Noda M, Yoshimi A, Usami M, Watanabe K, Morikawa M, Uno Y, Okada T, Mori D, Aleksic B, Ozaki N, Nagata KI. Possible involvement of a cell adhesion molecule, migfilin, in brain development and pathogenesis of autism spectrum disorders. Journal of neuroscience research. 2018;96(5):789-802.
    27. Iwata M, Iwamoto K, Kawano N, Kawaue T, Ozaki N. Evaluation method regarding the effect of psychotropic drugs on driving performance: A literature review. Psychiatry and clinical neurosciences. 2018;72(10):747-73.
    29. Kato K, Iwamoto K, Kawano N, Noda Y, Ozaki N, Noda A. Differential effects of physical activity and sleep duration on cognitive function in young adults. Journal of sport and health science. 2018;7(2):227-36.
    31. Kimura H, Kushima I, Yohimi A, Aleksic B, Ozaki N. Copy number variant in the region of adenosine kinase (adk) and its possible contribution to schizophrenia susceptibility. The international journal of neuropsychopharmacology. 2018;21(5):405-9.
    33. Kubota C, Inada T, Nakamura Y, Shiino T, Ando M, Aleksic B, Yamauchi A, Morikawa M, Okada T, Ohara M, Sato M, Murase S, Goto S, Kanai A, Ozaki N. Stable factor structure of the edinburgh postnatal depression scale during the whole peripartum period: Results from a japanese prospective cohort study. Scientific reports. 2018;8(1):17659.
    35. Kubota C, Okada T, Morikawa M, Nakamura Y, Yamauchi A, Ando M, Shiino T, Ohara M, Murase S, Goto S, Kanai A, Masuda T, Aleksic B, Ozaki N. Postpartum depression among women in nagoya indirectly exposed to the great east japan earthquake. Scientific reports. 2018;8(1):11624.
    37. Kunisawa K, Shimizu T, Kushima I, Aleksic B, Mori D, Osanai Y, Kobayashi K, Taylor AM, Bhat MA, Hayashi A, Baba H, Ozaki N, Ikenaka K. Dysregulation of schizophrenia-related aquaporin 3 through disruption of paranode influences neuronal viability. Journal of neurochemistry. 2018;147(3):395-408.
    39. Kushima I, Aleksic B, Nakatochi M, Shimamura T, Okada T, Uno Y, Morikawa M, Ishizuka K, Shiino T, Kimura H, Arioka Y, Yoshimi A, Takasaki Y, Yu Y, Nakamura Y, Yamamoto M, Iidaka T, Iritani S, Inada T, Ogawa N, Shishido E, Torii Y, Kawano N, Omura Y, Yoshikawa T, Uchiyama T, Yamamoto T, Ikeda M, Hashimoto R, Yamamori H, Yasuda Y, Someya T, Watanabe Y, Egawa J, Nunokawa A, Itokawa M, Arai M, Miyashita M, Kobori A, Suzuki M, Takahashi T, Usami M, Kodaira M, Watanabe K, Sasaki T, Kuwabara H, Tochigi M, Nishimura F, Yamasue H, Eriguchi Y, Benner S, Kojima M, Yassin W, Munesue T, Yokoyama S, Kimura R, Funabiki Y, Kosaka H, Ishitobi M, Ohmori T, Numata S, Yoshikawa T, Toyota T, Yamakawa K, Suzuki T, Inoue Y, Nakaoka K, Goto YI, Inagaki M, Hashimoto N, Kusumi I, Son S, Murai T, Ikegame T, Okada N, Kasai K, Kunimoto S, Mori D, Iwata N, Ozaki N. Comparative analyses of copy-number variation in autism spectrum disorder and schizophrenia reveal etiological overlap and biological insights. Cell reports. 2018;24(11):2838-56.
    41. Marui T, Torii Y, Iritani S, Sekiguchi H, Habuchi C, Fujishiro H, Oshima K, Niizato K, Hayashida S, Masaki K, Kira J, Ozaki N. The neuropathological study of myelin oligodendrocyte glycoprotein in the temporal lobe of schizophrenia patients. Acta neuropsychiatrica. 2018;30(4):232-40.
    43. Miyata A, Iwamoto K, Kawano N, Aleksic B, Ando M, Ebe K, Fujita K, Yokoyama M, Akiyama T, Igarashi Y, Ozaki N. Driving performance of stable outpatients with depression undergoing real-world treatment. Psychiatry and clinical neurosciences. 2018;72(6):399-408.
    45. Morita K, Miura K, Fujimoto M, Shishido E, Shiino T, Takahashi J, Yamamori H, Yasuda Y, Kudo N, Hirano Y, Koshiyama D, Okada N, Ikeda M, Onitsuka T, Ozaki N, Kasai K, Hashimoto R. Abnormalities of eye movement are associated with work hours in schizophrenia. Schizophrenia research. 2018;202:420-2.
    47. Mouri A, Ukai M, Uchida M, Hasegawa S, Taniguchi M, Ito T, Hida H, Yoshimi A, Yamada K, Kunimoto S, Ozaki N, Nabeshima T, Noda Y. Juvenile social defeat stress exposure persistently impairs social behaviors and neurogenesis. Neuropharmacology. 2018;133:23-37.
    49. Nakagawa T, Hiraga SI, Mizumura K, Hori K, Ozaki N, Koeda T. Topical thermal therapy with hot packs suppresses physical inactivity-induced mechanical hyperalgesia and up-regulation of ngf. The journal of physiological sciences : JPS. 2018;68(5):629-37.
    51. Ogasawara K, Nakamura Y, Kimura H, Aleksic B, Ozaki N. Issues on the diagnosis and etiopathogenesis of mood disorders: Reconsidering dsm-5. Journal of neural transmission (Vienna, Austria : 1996). 2018;125(2):211-22.
    53. Ohara M, Nakatochi M, Okada T, Aleksic B, Nakamura Y, Shiino T, Yamauchi A, Kubota C, Morikawa M, Murase S, Goto S, Kanai A, Kato R, Ando M, Ozaki N. Impact of perceived rearing and social support on bonding failure and depression among mothers: A longitudinal study of pregnant women. Journal of psychiatric research. 2018;105:71-7.
    55. Ozaki N. Right treatment for the right schizophrenic patients based on carbonyl stress pathophysiology. Psychiatry and clinical neurosciences. 2018;72(1):2.
    57. Reinbold CS, Forstner AJ, Hecker J, Fullerton JM, Hoffmann P, Hou L, Heilbronner U, Degenhardt F, Adli M, Akiyama K, Akula N, Ardau R, Arias B, Backlund L, Benabarre A, Bengesser S, Bhattacharjee AK, Biernacka JM, Birner A, Marie-Claire C, Cervantes P, Chen GB, Chen HC, Chillotti C, Clark SR, Colom F, Cousins DA, Cruceanu C, Czerski PM, Dayer A, Etain B, Falkai P, Frisen L, Gard S, Garnham JS, Goes FS, Grof P, Gruber O, Hashimoto R, Hauser J, Herms S, Jamain S, Jimenez E, Kahn JP, Kassem L, Kittel-Schneider S, Kliwicki S, Konig B, Kusumi I, Lackner N, Laje G, Landen M, Lavebratt C, Leboyer M, Leckband SG, Lopez Jaramillo CA, MacQueen G, Manchia M, Martinsson L, Mattheisen M, McCarthy MJ, McElroy SL, Mitjans M, Mondimore FM, Monteleone P, Nievergelt CM, Osby U, Ozaki N, Perlis RH, Pfennig A, Reich-Erkelenz D, Rouleau GA, Schofield PR, Schubert KO, Schweizer BW, Seemuller F, Severino G, Shekhtman T, Shilling PD, Shimoda K, Simhandl C, Slaney CM, Smoller JW, Squassina A, Stamm TJ, Stopkova P, Tighe SK, Tortorella A, Turecki G, Volkert J, Witt SH, Wright AJ, Young LT, Zandi PP, Potash JB, DePaulo JR, Bauer M, Reininghaus E, Novak T, Aubry JM, Maj M, Baune BT, Mitchell PB, Vieta E, Frye MA, Rybakowski JK, Kuo PH, Kato T, Grigoroiu-Serbanescu M, Reif A, Del Zompo M, Bellivier F, Schalling M, Wray NR, Kelsoe JR, Alda M, McMahon FJ, Schulze TG, Rietschel M, Nothen MM, Cichon S. Analysis of the influence of micrornas in lithium response in bipolar disorder. Frontiers in psychiatry. 2018;9:207.
    59. Sobue A, Kushima I, Nagai T, Shan W, Kohno T, Aleksic B, Aoyama Y, Mori D, Arioka Y, Kawano N, Yamamoto M, Hattori M, Nabeshima T, Yamada K, Ozaki N. Genetic and animal model analyses reveal the pathogenic role of a novel deletion of reln in schizophrenia. Scientific reports. 2018;8(1):13046.
    61. Takata A, Miyake N, Tsurusaki Y, Fukai R, Miyatake S, Koshimizu E, Kushima I, Okada T, Morikawa M, Uno Y, Ishizuka K, Nakamura K, Tsujii M, Yoshikawa T, Toyota T, Okamoto N, Hiraki Y, Hashimoto R, Yasuda Y, Saitoh S, Ohashi K, Sakai Y, Ohga S, Hara T, Kato M, Nakamura K, Ito A, Seiwa C, Shirahata E, Osaka H, Matsumoto A, Takeshita S, Tohyama J, Saikusa T, Matsuishi T, Nakamura T, Tsuboi T, Kato T, Suzuki T, Saitsu H, Nakashima M, Mizuguchi T, Tanaka F, Mori N, Ozaki N, Matsumoto N. Integrative analyses of de novo mutations provide deeper biological insights into autism spectrum disorder. Cell reports. 2018;22(3):734-47.
    63. Tsuruta Y, Iwamoto K, Banno M, Kawano N, Kohmura K, Miyata S, Fujishiro H, Noda Y, Noda A, Iritani S, Ozaki N. Effects of hypnotics on prefrontal cortex activity during a verbal fluency task in healthy male subjects: A near-infrared spectroscopy study. Human psychopharmacology. 2018;33(6):e2678.
    65. Yamamoto M, Kushima I, Suzuki R, Branko A, Kawano N, Inada T, Iidaka T, Ozaki N. Aberrant functional connectivity between the thalamus and visual cortex is related to attentional impairment in schizophrenia. Psychiatry research Neuroimaging. 2018;278:35-41.
    67. Yamasue H, Okada T, Munesue T, Kuroda M, Fujioka T, Uno Y, Matsumoto K, Kuwabara H, Mori D, Okamoto Y, Yoshimura Y, Kawakubo Y, Arioka Y, Kojima M, Yuhi T, Owada K, Yassin W, Kushima I, Benner S, Ogawa N, Eriguchi Y, Kawano N, Uemura Y, Yamamoto M, Kano Y, Kasai K, Higashida H, Ozaki N, Kosaka H. Effect of intranasal oxytocin on the core social symptoms of autism spectrum disorder: A randomized clinical trial. Molecular psychiatry. 2018.
    69. Yamauchi A, Okada T, Ando M, Morikawa M, Nakamura Y, Kubota C, Ohara M, Murase S, Goto S, Kanai A, Ozaki N. Validation and factor analysis of the japanese version of the highs scale in perinatal women. Frontiers in psychiatry. 2018;9:269.
    71. Yu Y, Lin Y, Takasaki Y, Wang C, Kimura H, Xing J, Ishizuka K, Toyama M, Kushima I, Mori D, Arioka Y, Uno Y, Shiino T, Nakamura Y, Okada T, Morikawa M, Ikeda M, Iwata N, Okahisa Y, Takaki M, Sakamoto S, Someya T, Egawa J, Usami M, Kodaira M, Yoshimi A, Oya-Ito T, Aleksic B, Ohno K, Ozaki N. Rare loss of function mutations in n-methyl-d-aspartate glutamate receptors and their contributions to schizophrenia susceptibility. Translational psychiatry. 2018;8(1):12.
    73. Yukawa T, Iwakura Y, Takei N, Saito M, Watanabe Y, Toyooka K, Igarashi M, Niizato K, Oshima K, Kunii Y, Yabe H, Matsumoto J, Wada A, Hino M, Iritani S, Niwa SI, Takeuchi R, Takahashi H, Kakita A, Someya T, Nawa H. Pathological alterations of chondroitin sulfate moiety in postmortem hippocampus of patients with schizophrenia. Psychiatry research. 2018;270:940-6.

Research Keywords

Psychiatry, child and adolescent psychiatry, schizophrenia, depression, bipolar disorder, dementia, autistic spectrum disorder, anxiety disorder, somatoform disorder, dental and oral surgery, cancer, organ transplantation, heart failure, omics, genome, genetic modification, model animal, iPS cell, neuroimaging, MRI, postmortem brain, pain, psychotropic agent, geriatric, parturient, genome cohort, epigenome, sleep

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Call for graduate students

We conduct research to elucidate the pathophysiological mechanisms of psychiatric disorders, as well as studies based on clinical practice. While these studies may not lead directly to the development of new medicines, they are essential for developing better treatments in the future and addressing the social impact of drug side effects. That is why we are committed to building 'higher quality evidence'.

We teach essential skills for advancing research, including literature searching and critical review, study design, laboratory notebook writing, data analysis, data presentation and scientific writing. We aim not only to lay the foundations for future research, but also to cultivate a scientific perspective that can be applied in clinical settings.

We also welcome applicants from non-medical backgrounds such as psychology, pharmacy and health sciences.

There are opportunities to undertake a research-focused doctoral programme, or to continue studies as a working professional while maintaining psychiatric duties in core and affiliated institutions.

See the Research section for more information.