Laboratories

Department of Preventive Medicine

KEYWORDS

  • Cohort study
  • Nutrition
  • Phsical activity
  • Social epidemiology
  • Oral health

HEAD

WAKAI Kenji

Professor

Researchers

LAB MEMBER

Faculty Position Researchers
TAMURA Takashi Associate Professor Researchers
NAGAYOSHI Mako Lecturer Researchers
MATSUNAGA Takashi Assistant Professor Researchers

CONTACT

Email yobojim◎med.nagoya-u.ac.jp (Please send a message after replacing "◎" mark with "@" mark. )
HP Private Page

OUTLINE

This department is a research and education group that has inherited the Department of Preventive Medicine established in 1941, aiming to elucidate diseases and health risks through epidemiological research. The current research mainly focuses on cohort studies, and since 2005, it has served as the central office for the Japan Multi-Institutional Collaborative Cohort Study (J-MICC Study), which involves more than 100,000 participants nationwide, in collaboration with the Aichi Cancer Center Research Institute. Additionally, it is responsible for follow-up surveys in the Shizuoka area (Seirei Preventive Health Center, Hamamatsu City), Daiko Study (School of Health Sciences, former Daiko Medical Center, Nagoya City), and Iga City Cohort Study (Iga City General Hospital, Iga City). Furthermore, the group also serves as the administrative office for the JACC Study, a large-scale cohort study with approximately 110,000 participants, for which 20 years of follow-up surveys have already been completed. Efforts are being made to ensure that these valuable data assets are widely utilized by researchers.

RESEARCH PROJECTS

  • The Japan Multi-Institutional Collaborative Cohort Study (J-MICC Study)
  • The Japan Collaborative Cohort Study for Evaluation of Cancer Risk (JACC Study)
  • Longitudinal Evaluation of Multi-phasic, Odontological and Nutritional Associations in Dentists Study (LEMONADE Study)

BIBLIOGRAPHY

2025
  1. Nakane H, Tamura T, Nagayoshi M, Okada R, Takeuchi K, Nakamura Y, Suzuki S, Takashima N, Koyama T, Arisawa K, Ikezaki H, Tanaka K, Nishimoto D, Momozawa Y, Hamajima N, Tanaka H, Wakai K, Matsuo K, for the J-MICC Study Group. A polymorphism in the DOCK7 gene (rs1167998) is associated with salt restriction behavior in hypertensive patients. Nagoya J Med Sci 2026 May;88(2) (in press).
  2. Kato Y, Tamura T, Wakai K, Kubo Y, Okada R, Matsunaga T, Nagayoshi M, Imaeda N, Goto C, Otonari J, Ikezaki H, Hara M, Nishida Y, Michihata N, Nakamura Y, Tanoue S, Ibusuki R, Suzuki S, Otani T, Koyanagi YN, Ito H, Ozaki E, Watanabe I, Kuriki K, Takashima N, Miyagawa N, Katsuura-Kamano S, Watanabe T, Hishida A, Matsuo K. Associations of vegetable and fruit consumption with all-cause and cause-specific mortality in the Japanese population: the Japan multi- institutional collaborative cohort study. Nutr J. 2025 Nov 22;25(1):2.
  3. Matsunaga T, Kikuchi H, Inoue S, Ihira H, Yamaji T, Iwasaki M, Inoue M, Tsugane S, Sawada N. Moderate-to-vigorous physical activity and total and site- specific cancer: the Japan Public Health Center-based Prospective Study. J Epidemiol. 2025 Oct 4. doi: 10.2188/jea.JE20250041. Epub ahead of print. PMID: 41047348.
  4. Nagayoshi M, Tamai M, Takeuchi K, Yamanashi H, Koyamatsu J, Nonaka F, Nobusue K, Honda Y, Kawashiri SY, Nagata Y, Maeda T. Frequency of Conversation, Laughter and Other Vocalising Opportunities in Daily Life and Maximum Tongue Pressure: The Goto Longevity Study. J Oral Rehabil. 2025 Sep;52(9):1288-1296. doi: 10.1111/joor.13979. Epub 2025 Apr 22. PMID: 40260895; PMCID: PMC12408979.
  5. Sasakabe T, Wakai K, Kawai S, Lin Y, Hishida A, Iso H, Kikuchi S, Tamakoshi A; Japan Collaborative Cohort Study Group. Low-Carbohydrate Diet Score and Risk of Mortality: The Japan Collaborative Cohort Study. J Nutr. 2025 Apr;155(4):1218-1225.
  6. Nagayoshi M, Kachi Y, Kato T, Ochi M, Ichinose Y, Kondo T, Takehara K. Response to the Letter: \"Enhancing the Understanding of Paternal Involvement in Childcare and Its Impact on Maternal Disciplinary Practices\". J Epidemiol. 2025 May 5;35(5):252-253.
2024
  1. Nagayoshi M, Kachi Y, Kato T, Ochi M, Ichinose Y, Kondo T, Takehara K. Paternal Involvement in Childcare and Housework and Mothers' Spanking Behavior: The Japanese Longitudinal Survey of Newborns in the 21st Century. J Epidemiol. 2024 Dec 5;34(12):577-586. doi: 10.2188/jea.JE20230270. Epub 2024 Oct 31. PMID: 38853010; PMCID: PMC11564066.
  2. Matsunaga T, Wakai K, Imaeda N, Goto C, Tamada Y, Kato Y, Kubo Y, Okada R, Nagayoshi M, Tamura T, Hishida A, Ikezaki H, Otonari J, Takashima N, Miyagawa N, Matsuo K; Japan Multi-Institutional Collaborative Cohort (J-MICC) Study Group. Food group intakes and high-sensitivity C-reactive protein among community- dwelling Japanese adults: a cross-sectional study. Public Health Nutr. 2024 Oct 18;27(1):e212.
  3. Tsukamoto M, Hishida A, Tamura T, Nagayoshi M, Okada R, Kubo Y, Kato Y, Hamajima N, Nishida Y, Shimanoe C, Ibusuki R, Shibuya K, Takashima N, Nakamura Y, Kusakabe M, Nakamura Y, Koyanagi YN, Oze I, Nishiyama T, Suzuki S, Watanabe I, Matsui D, Otonari J, Ikezaki H, Katsuura-Kamano S, Arisawa K, Kuriki K, Nakatochi M, Momozawa Y, Takeuchi K, Wakai K, Matsuo K. GWAS of Folate Metabolism With Gene-environment Interaction Analysis Revealed the Possible Role of Lifestyles in the Control of Blood Folate Metabolites in Japanese: The J-MICC Study. J Epidemiol. 2024 May 5;34(5):228-237.
  4. Kasahara C, Tamura T, Wakai K, Tamada Y, Kato Y, Kubo Y, Okada R, Nagayoshi M, Hishida A, Imaeda N, Goto C, Otonari J, Ikezaki H, Nishida Y, Shimanoe C, Oze I, Koyanagi YN, Nakamura Y, Kusakabe M, Nishimoto D, Shimoshikiryo I, Suzuki S, Watanabe M, Ozaki E, Omichi C, Kuriki K, Takashima N, Miyagawa N, Arisawa K, Katsuura-Kamano S, Takeuchi K, Matsuo K; J-MICC Study Group. Association between consumption of small fish and all-cause mortality among Japanese: the Japan Multi-Institutional Collaborative Cohort Study. Public Health Nutr. 2024 May 3;27(1):e135.
2023
  1. Tamura T, Wakai K, Kato Y, Tamada Y, Kubo Y, Okada R, Nagayoshi M, Hishida A, Imaeda N, Goto C, Ikezaki H, Otonari J, Hara M, Tanaka K, Nakamura Y, Kusakabe M, Ibusuki R, Koriyama C, Oze I, Ito H, Suzuki S, Nakagawa-Senda H, Ozaki E, Matsui D, Kuriki K, Kondo K, Takashima N, Watanabe T, Katsuura-Kamano S, Matsuo K; Japan Multi-Institutional Collaborative Cohort (J-MICC) Study. Dietary Carbohydrate and Fat Intakes and Risk of Mortality in the Japanese Population: the Japan Multi-Institutional Collaborative Cohort Study. J Nutr. 2023 Aug;153(8):2352-2368.
  2. Nagayoshi M, Hishida A, Shimizu T, Kato Y, Kubo Y, Okada R, Tamura T, Otonari J, Ikezaki H, Hara M, Nishida Y, Oze I, Koyanagi YN, Nakamura Y, Kusakabe M, Ibusuki R, Shibuya K, Suzuki S, Nishiyama T, Koyama T, Ozaki E, Kuriki K, Takashima N, Nakamura Y, Katsuura-Kamano S, Arisawa K, Nakatochi M, Momozawa Y, Takeuchi K, Wakai K. BMI and Cardiometabolic Traits in Japanese: A Mendelian Randomization Study. J Epidemiol. 2024 Feb 5;34(2):51-62. doi: 10.2188/jea.JE20220154. Epub 2023 May 31. PMID: 36709979; PMCID: PMC10751192.
  3. Nagayoshi M, Takeuchi K, Tamada Y, Kato Y, Kubo Y, Okada R, Tamura T, Hishida A, Otonari J, Ikezaki H, Nishida Y, Shimanoe C, Koyanagi YN, Matsuo K, Mikami H, Kusakabe M, Nishimoto D, Shibuya K, Suzuki S, Nishiyama T, Ozaki E, Watanabe I, Kuriki K, Takashima N, Kadota A, Arisawa K, Katsuura-Kamano S, Wakai K. Sex-specific Relationship Between Stress Coping Strategies and All-cause Mortality: Japan Multi-Institutional Collaborative Cohort Study. J Epidemiol. 2023 May 5;33(5):236-245.

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