Molecular/Cellular Neuroscience

2026

1. Hung CJ#, Ueda S#, Rahaman SM, Yamamoto M, Li J, Fukatsu N, Bito H, Yamaguchi H, Yamanaka A, Takemoto-Kimura S, Ono D. (#equal contribution) Neurotensin in the extended amygdala maintains wakefulness in novel environments. Proc. Natl. Acad. Sci. USA. 2026 Feb 10;123(6):e2521268123

2025

1. Ueda S, Kakita M, Hosokawa M, Arikawa K, Takahashi K, Shiota R, Kakeyama M, Matsunaga H, Takeyama H, Takemoto-Kimura S. Divergent and Subnucleus-Specific Gene Expression Responses to Chronic Stress Hormone Exposure in the Amygdala. Front. Mol. Neurosci. 2025 Sep 12; 18:1659846.
2. Pan M#, Liu PW#, Ozawa Y#, Arima-Yoshida F, Dong G, Sawahata M, Mori D, Nagase M, Fujii H, Ueda S, Yabuuchi Y, Liu X, Narita H, Konno A, Hirai H, Ozaki N, Yamada K, Kidokoro H, Bito H, Mizoguchi H, M Watabe A, Horigane S, Takemoto-Kimura S. (#equal contribution) A hyper-activatable CAMK2A variant associated with intellectual disability causes exaggerated long-term potentiation and learning impairments. Transl. Psychiatry 2025 Mar 26; 15(1):95.

2023

1. Ageta-Ishihara N#, Takemoto-Kimura S#, Kondo Y, Okamura M, Bito H. (#equal contribution)Lipidation states orchestrate CLICK-III/CaMKIγ's stepwise association with Golgi and rafts-enriched membranes and specify its functional coupling to STEF-Rac1-dependent neurite extension. Front. Cell. Neurosci. 2023 Aug 3; 17:1204302.
2. Hamada S#, Mikami K#, Ueda S#, Nagase M#, Nagashima T, Yamamoto M, Bito H, Takemoto-Kimura S, Ohtsuka T, Watabe AM. (#equal contribution)Experience-dependent changes in affective valence of taste in male mice. Mol. Brain 2023 Mar 11; 16(1):28.

2022

1. Fujii H, Kidokoro H, Kondo Y, Kawaguchi M, Horigane S, Natsume J, Takemoto-Kimura S, Bito H. Förster resonance energy transfer-based kinase mutation phenotyping reveals an aberrant facilitation of Ca2+/calmodulin-dependent CaMKIIα activity in de novo mutations related to intellectual disability. Front. Mol. Neurosci. 2022 Sep 1; 15:970031.
2. Wang C#, Horigane S#, Wakamori M#, Ueda S, Kawabata T, Fujii H, Kushima I, Kimura H, Ishizuka K, Nakamura Y, Iwayama Y, Ikeda M, Iwata N, Okada T, Aleksic B†, Mori D, Yoshida T, Bito H, Yoshikawa T, Takemoto-Kimura S†, Ozaki N. (#equal contribution, †co-corresponding authors) Identification of ultra-rare disruptive variants in voltage-gated calcium channel-encoding genes in Japanese samples of schizophrenia and autism spectrum disorder. Transl. Psychiatry 2022 Feb 26; 12(1):84.
3. Sakamoto M, Inoue M, Takeuchi A, Kobari S, Yokoyama T, Horigane S, Takemoto-Kimura S, Abe M, Sakimura K, Kano M, Kitamura K, Fujii H, Bito H. A Flp-dependent G-CaMP9a transgenic mouse for neuronal imaging in vivo. Cell Rep. Methods 2022 Feb 14; 2(2):100168.

2021

1. Ueda S, Hosokawa M, Arikawa K, Takahashi K, Fujiwara M, Kakita M, Fukada T, Koyama H, Horigane S, Itoi K, Kakeyama M, Matsunaga H, Takeyama H, Bito H, Takemoto-Kimura S. Distinctive Regulation of Emotional Behaviors and Fear-Related Gene Expression Responses in Two Extended Amygdala Subnuclei With Similar Molecular Profiles. Front. Mol. Neurosci. 2021 Sep 3; 14:741895.
2. Matsubara T, Yanagida T, Kawaguchi N, Nakano T, Yoshimoto J, Sezaki M, Takizawa H, Tsunoda SP, Horigane S, Ueda S, Takemoto-Kimura S, Kandori H, Yamanaka A, Yamashita T. Remote control of neural function by X-ray-induced scintillation. Nat. Commun. 2021 Jul 22; 12(1):4478.

2020

1. Horigane S#, Ozawa Y#, Zhang J#, Todoroki H, Pan M, Haijima A, Yanagawa Y, Ueda S, Nakamura S, Kakeyama M†, Takemoto-Kimura S†.(#equal contribution, †co-corresponding authors)A mouse model of Timothy syndrome exhibits altered social competitive dominance and inhibitory neuron development.
2. Horigane S, Hamada S, Kamijo S, Yamada H, Yamasaki M, Watanabe M, Bito H, Ohtsuka T, Takemoto-Kimura S. Development of an L-type Ca2+ channel-dependent Ca2+ transient during the radial migration of cortical excitatory neurons. Neurosci. Res. 2020 Jun 26; 169:17-26.

2019

1. Inoue M, Takeuchi A, Manita S, Horigane S, Sakamoto M, Kawakami R, Yamaguchi K, Otomo K, Yokoyama H, Kim R, Yokoyama T, Takemoto-Kimura S, Abe M, Okamura M, Kondo Y, Quirin S, Ramakrishnan C, Imamura T, Sakimura K, Nemoto T, Kano M, Fujii H, Deisseroth K, Kitamura K, Bito H.Rational Engineering of XCaMPs, a Multicolor GECI Suite for In Vivo Imaging of Complex Brain Circuit Dynamics. Cell 2019 May 16; 177(5):1346-1360.

2018

1. Nishiguchi KM, Fujita K, Tokashiki N, Komamura H, Takemoto-Kimura S, Okuno H, Bito H, Nakazawa T.Retained Plasticity and Substantial Recovery of Rod-Mediated Visual Acuity at the Visual Cortex in Blind Adult Mice with Retinal Dystrophy. Mol. Ther. 2018 Oct 3;26(10):2397-2406.
2. Kamijo S, Ishii Y, Horigane S, Suzuki K, Ohkura M, Nakai J, Fujii H, Takemoto-Kimura S, Bito H.A Critical Neurodevelopmental Role for L-Type Voltage-Gated Calcium Channels in Neurite Extension and Radial Migration. J. Neurosci. 2018 Jun 13; 38(24):5551-5566.

2016

1. Horigane S, Ageta-Ishihara N, Kamijo S, Fujii H, Okamura M, Kinoshita M, Takemoto-Kimura S*, Bito H*. Facilitation of axon outgrowth via a Wnt5a-CaMKK-CaMKIalpha pathway during neuronal polarization. Molecular Brain 16;9(1):8. doi:10.1186/s13041-016-0189-3 (2016) (*co-corresponding authors)

2015

1. Inoue M, Takeuchi A, Horigane S, Ohkura M, Gengyo-Ando K, Fujii H, Kamijo S, Takemoto-Kimura S, Kano M, Nakai J, Kitamura K, BitoH: Rational design of a high-affinity, fast, red calcium indicator R-CaMP2. Nat Methods 12(1): 64-70 (2015)

2014

1. Nonaka M, Kim R, Sharry S, Matsushima A, Takemoto-Kimura S, Bito H: Towards a better understanding of cognitive behaviors regulated by gene expression downstream of activity-dependent transcription factors. Neurobiol Learn Mem 115: 21-9 (2014)
2. Nonaka M, Kim R, Fukushima H, Sasaki K, Suzuki K, Okamura M, Ishii Y, Kawashima T, Kamijo S, Takemoto-Kimura S, Okuno H, Kida S, Bito H.: Region-Specific Activation of CRTC1-CREB Signaling Mediates Long-Term Fear Memory. Neuron 84(1): 92-106 (2014)

2013

1. Kawashima T, Kitamura K, Suzuki K, Nonaka M, Kamijo S, Takemoto-Kimura S, Kano M, Okuno H, Ohki K, Bito H. Functional labeling of neurons and their projections using the synthetic activity-dependent promoter E-SARE. Nat Methods 10, 889-895 (2013)
2. Fujii H, Inoue M, Okuno H, Sano Y, Takemoto-Kimura S, Kitamura K, Kano M, Bito H. Nonlinear decoding and asymmetric representation of neuronal input information by CaMKIIα and calcineurin. Cell Rep 3, 978-987 (2013)

2012

1. Okuno H, Akashi K, Ishii Y, Yagishita-Kyo N, Suzuki K, Nonaka M, Kawashima T, Fujii H, Takemoto-Kimura S, Abe M, Natsume R, Chowdhury S, Sakimura K, Worley PF and Bito H. Inverse Synaptic Tagging of Inactive Synapses via Dynamic Interaction of Arc/Arg3.1 with CaMKIIbeta. Cell 149, 886-898 (2012)

2009

1. Ageta-Ishihara N, Takemoto-Kimura S, Nonaka M, Adachi-Morishima A, Suzuki K, Kamijo S, Fujii H, Mano T, Blaeser F, Chatila TA, Mizuno H, Hirano T, Tagawa Y, Okuno H and Bito H. Control of cortical axon elongation by a GABA-driven Ca2+/calmodulin-dependent protein kinase cascade. J Neurosci 29, 13720-13729 (2009)
2. Kawashima T, Okuno H, Nonaka M, Adachi-Morishima A, Kyo N, Okamura M, Takemoto-Kimura S, Worley PF and Bito H. Synaptic activity-responsive element in the Arc/Arg3.1 promoter essential for synapse-to-nucleus signaling in activated neurons. Proc Natl Acad Sci USA 106, 316-321 (2009)

2008

1. Bito H, Takemoto-Kimura S, Okuno H. Activity-dependent gene regulation: How do synapses talk to the nucleus and fine-tune neuronal outputs? in “Molecular Pain“. (M. Zhuo ed., Springer, New York), 207-217 (2008)

2007

1. Takemoto-Kimura S, Ageta-Ishihara N, Nonaka M, Adachi-Morishima A, Mano T, Okamura M, Fujii H, Fuse T, Hoshino M, Suzuki S, Kojima M, Mishina M, Okuno H and Bito H. Regulation of dendritogenesis via a lipid-raft-associated Ca2+/calmodulin-dependent protein kinase CLICK-III/CaMKIgamma. Neuron 54, 755-770 (2007)
2. Fuse T, Ohmae S, Takemoto-Kimura S, Bito H. DCLK1.
3. AfCS/Nature Molecule Pages, doi:10.1038/mp.a003011.01 (2007)

2006

1. Sato K, Suematsu A, Nakashima T, Takemoto-Kimura S, Aoki K, Morishita Y, Asahara H, Ohya K, Yamaguchi A, Takai T, Kodama T, Chatila TA, Bito H and Takayanagi H. Regulation of osteoclast differentiation and function by the CaMK-CREB pathway. Nat Methods 12, 1410-1416 (2006)
2. Ohmae S, Takemoto-Kimura S, Okamura M, Adachi-Morishima A., Nonaka M, Fuse T, Kida S, Tanji M, Furuyashiki T, Arakawa Y, Narumiya S, Okuno H and Bito H. Molecular identification and characterization of a family of kinases with homology to Ca2+/calmodulin-dependent protein kinases I/IV. J Biol Chem 281, 20427-20439 (2006)
3. Nonaka M, Doi T, Fujiyoshi Y, Takemoto-Kimura S and Bito H. Essential contribution of the ligand-binding beta B/beta C loop of PDZ1 and PDZ2 in the regulation of postsynaptic clustering, scaffolding, and localization of postsynaptic density-95. J Neurosci 26, 763-774 (2006)

2003

1. Takemoto-Kimura S, Terai H, Takamoto M, Ohmae S, Kikumura S, Segi E, Arakawa Y, Furuyashiki T, Narumiya S and Bito H. Molecular cloning and characterization of CLICK-III/CaMKIgamma, a novel membrane-anchored neuronal Ca2+/calmodulin-dependent protein kinase (CaMK). J Biol Chem 278, 18597-18605 (2003)
2. Arakawa Y, Bito H, Furuyashiki T, Tsuji T, Takemoto-Kimura S, Kimura K, Nozaki K, Hashimoto N and Narumiya S. Control of axon elongation via an SDF-1alpha/Rho/mDia pathway in cultured cerebellar granule neurons. J Cell Biol 161, 381-391 (2003)
3. Bito H and Takemoto-Kimura S. Ca2+/CREB/CBP-dependent gene regulation: a shared mechanism critical in long-term synaptic plasticity and neuronal survival.
4. Cell Calcium 34, 425-430 (2003)

2002

1. Furuyashiki T, Arakawa Y, Takemoto-Kimura S, Bito H and Narumiya S. Multiple spatiotemporal modes of actin reorganization by NMDA receptors and voltage-gated Ca2+ channels. Proc Natl Acad Sci USA 99, 14458-14463 (2002)