Nagoya Journal of Medical Science

Clear cell carcinoma rarely appears in the jaws. We here reported two possible cases of such rare carcinoma. Microscopic examination and the clinical features indicated case NO. 1 being a renal cell carcinoma metastasized to the mandible, and case NO.2 being a primary acinic cell carcinoma originated from the minor salivary gland.

A 3-year-old girl with mental retardation and a cleft palate disclosed hyperglycinuria. Serum glycine concentration was within the normal limits and renal clearance of glycine was elevated. Oral loading test of glycine showed that the intestinal absorption of glycine seemed to be nonnal. With intravenous loading of glycine, maximum tubular reabsorption rate (Tm) for glycine could not be obtained. Intravenous infusion of L-proline indicated that the Tm for proline was about half the normal value and that the impaired glycine reabsorption was further depressed. The patient's mother also had a reduced Tm for proline although she did not exhibit distinct hyperglycinuria. It seems likely that the patient and her mother have a heterozygous trait for iminoglycinuria.

A virus newly isolated from the smoky-brown cockroach, Periplaneta fuliginosa, was characterized. The virus showed hexagonal structure with a diameter of 19-21 mμ and had a sedimentation value of approximately 110S and a buoyant density of 1.41 g/ml. Neither treatment with chloroform nor heating at 56°C destroyed its infectivity. The virus was stable at pH 3.0. The virus consisted of about 31% of deoxyribonucleic acid and 69% protein. The viral DNA in situ was suggested to be single-stranded by staining property of the virus with acridine orange as well as by reaction to formaldehyde. Furthermore, it was demonstrated that the viral DNA extracted in low salt buffer exhibited single·stranded nature, whereas in high salt buffer double-stranded. Four virion proteins, VP I (MW., 48,000), VP II (M.W., 52,000), VP III (MW., 61,000) and VP IV (MW., 76,000) were detected by SDS-polyacrylamide gel electrophoresis, and they accounted for 6, 58, 30 and 6% of the total viral protein, respectively. These data indicate that the new isolate belongs to the Densovirus of the family Parvoviridae.

To clarify the effect of large dose intratumoral administration of OK-432, experimental and clinical investigations were perfomed. In the experimental study, 250 KE/Kg OK-432 was administered into S-180 sarcoma in ddN mice. Mice treated by OK-432 showed significant increase in delayed hypersensitivity reaction and elongation in the survival times. In the clinical study, 50 KE OK-432 was injected intratumorally during the surgery for the advanced and inoperable malignancy. PHA and PPD skin test reactions, IgG titers, and lymphocyte counts were elevated in the group received the large dose of OK-432. The treatment seemed to contribute to the prolongation of survival times during 3 months after the operation.