Review
Transduction and Encoding Mechanisms in Muscle Spindle
FUMlO ITO and YUKIO KOMATSU
pg(s) 37 - 48
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Original Articles
Effects of Streptococcal Preparation OK-432 on Chemicallyinduced Intestinal Carcinoma in Rats
HIDEHITO ICHIHASHI, HAJIME KUZUYA and TATSUHEI KONDO
pg(s) 49 - 54
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Intestinal tumors were induced by repeated subcutaneous injection of 1,2-dimethylhydrazine in
Donryu strain rats for 28 weeks. A streptococcal preparation, OK-432 was administered at
different times of the tumor induction. Between the OK-432 treated and the untreated groups no
significant difference was observed in the incidence of intestinal tumors, the total number of
tumors per rat, the location of tumors, or the survival time. Though low incidence of extra-
intestinal malignancies in the OK-432 treated animals seemed to be the only positive finding,
it was not statistically significant.
Extraction of Leukemia Associated antigen (LAA) and
Active Specific Immunization with LAA in Acute Leukemia
KOHJI EZAKI
pg(s) 55 - 68
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Leukemia associated antigen (LAA) was prepared from leukemia cells, using hypotonic lysis
and low frequency sonications, followed by diethylaminoethyl (DEAE) cellulose column chromatography. Four protein peaks were eluted by stepwise introduction of increased concentration
of NaCl solutions. With running on polyacrylamide gel electrophoresis (PAGE), unique bands
which were not present in extracts of remission bone marrow, appeared in eluates of higher mol
NaCl solution. These eluates produced positive blastogenic response when incubated with
autologous remission lymphocytes. Active specific immunization with pooled allogeneic LAA
was performed in 14 adult AML patients in complete remission. Immunization was done weekly
for 3 weeks and immunological studies (measurement of in vitro lymphocyte blastogenic responses
and delayed hypersensitivity skin reactions) were done weekly for 5 weeks. Twelve out of 14
patients showed increased blastogenic responses to LAA after immunization, and 9 out of 10
studied showed increased blastogenic responses to irradiated autologous leukemia cells. Significant
increases in blastogenic responses to both LAA and autologous leukemia cells were noticed on
day 22 (p < 0.05). The increase of blastogenic responses seems to be higher among the patients
whose length of remission was over 12 months at the time of immunization. There was no overall
significant difference between blastogenic responses in autologous serum or pooled AB(+) serum.
Increased skin test reactivity to LAA after immunization was seen in 7 out of 14 patients. Those
patients with an initially weak reaction showed increased reactivity after immunization. There
was no correlation between blastogenic responses and skin test reactivity.
Conference
Comparative Studies on the Transduction Mechanisms and
its Controls in Mechanoreceptors
FUMIO ITO
pg(s) 69 - 71
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Gap Junctions between Hair Cells and Supporting Cells in the
Goldfish Saccular Macula. A Freeze Fracture Study.
KIYOSHI HAMA
pg(s) 71 - 74
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The Acousticolateralis System and Ionic Environments
K. YANAGISAWA, K. SHIOZAWA and A. ASANUMA
pg(s) 74 - 75
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Auditory Afferent and Efferent Neyrons in the Mouse Brain Stem Studied
by Axonal Transport of Horseradish Peroxidase
IKUO TANIGUCHI
pg(s) 75 - 77
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Intracellular Potentials of the Organ of Corti in Guinea pigs
Y. TANAKA, A. ASANUMA and K. YANAGISAWA
pg(s) 78 - 80
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Scanning Electron Microscopic Image of Neuromuscular Junctions
YASUO UEHARA and JUNZO DESAKI
pg(s) 80 - 82
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High Potassium Effect on the Mobility of Sea Urchin Sperm
TOHRU YOSHIOKA and HIROKO INOUE
pg(s) 82 - 84
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Inhibition on Cochlear Nerve Fibers by the Sound-Activated
Olivocochlear Bundle
KEIICHI MURATA, TEIJI TANAHASHI, JUNSEI HORIKAWA and HIROAKI FUNAI
pg(s) 84 - 86
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Structural Bases of Crustacean Mechano-sensory Hair Function
NOBUO KOUYAMA, TATEO SHIMOZAWA and MITUHIKO HISADA
pg(s) 86 - 88
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A Model of Transduction in the Frog Muscle Spindle
FUMIO ITO, YUKIO KOMATSU and NOBUHIRO KANEKO
pg(s) 89- 91
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