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教室研究業績(2012〜1994) 更新日'12.7.3
西山幸廣教授 個人業績
木村准教授 個人業績
五島助教 個人業績.
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更新日'12.7.3
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Kawabe S, Ito Y, Gotoh K, Kojima
S, Matsumoto K, Kinoshita T, Iwata S, Nishiyama Y, Kimura H.
Pretreatment
EBV-DNA copy number is predictive of response and toxicities to
SMILE chemotherapy for extranodal NK/T-cell lymphoma, nasal type.
Cancer
Science in press
Ito Y, Kimura H, Maeda Y, Hashimoto
C, Ishida F, Izutsu K, Sueoka E, Isobe Y, Takizawa J, Hasegawa
Y, Kobayashi H, Okamura S, Kobayashi H, Yamaguchi M, Suzumiya
J, Hyo R, Nakamura S, Kawa K, Oshimi K, Suzuki R.
Application
of flow cytometric in situ hybridization assay to EpsteinﾐBarr
virus-associated T/NK lymphoproliferative diseases.
Clinical
Cancer Research in press
Esaki S, Yamano K, Kiguchi J,
Katsumi S, Keceli S, Okamoto H, Goshima F, Kimura H,
Nishiyama
Y, Murakami S. Diabetic mice show an aggravated course of herpes-simplex-virus-induced
facial nerve paralysis.
Otology
& Neurotology in press
Yasuda
K, Sugiura K, Ishikawa R, Kihira M, Negishi Y, Iwayama H, Ito
K, Kimura H, Kosugi I, Akiyama M.
Perinatal
cytomegalovirus-associated bullae in an immunocompetent infant.
Archives
of Dermatology in press
Hirai Y,
Yamamoto T, Kimura H, Ito Y, Tsuji K, Miyake T, Morizane S, Suzuki
D, Fujii K, Iwatsuki K.
Hydroa
vacciniforme is associated with increased numbers of Epstein-Barr
virus-infected gd T-cells.
Journal
of Investigative Dermatology
in press
Kawada
J, Iwata N, Kitagawa Y, Kimura H, Ito Y.
Prospective
monitoring of Epstein-Barr virus and other herpesviruses in patients
with juvenile idiopathic arthritis treated with methotrexate and
tocilizumab.
Modern
Rheumatology in press
Kimura
H, Ito Y, Kawabe S, Gotoh K, Takahashi Y, Kojima S, Naoe T, Esaki
S, Kikuta A, Sawada A, Kawa K, Ohshima K, Nakamura S.
Epstein-Barr
virus (EBV)-associated T/NK lymphoproliferative diseases in non-immunocompromised
hosts: prospective analysis of 108 cases.
Blood 119:673-86 (2012)
Isobe Y,
Aritaka N, Setoguchi Y, Ito Y, Kimura H, Hamano Y, Sugimoto K,
Komatsu N.
T/NK-cell
type chronic active Epstein-Barr virus (EBV) disease in adults:
an underlying condition for EBV-associated T/NK-cell lymphoma.
Journal
of Clinical Pathology 65:
278-82 (2012)
Iwata S,
Saito T, Ito Y, Kamakura M, Gotoh K, Kawada J, Nishiyama Y, Kimura
H.
Antitumor
activities of valproic acid on Epstein-Barr virus-associated T
and natural killer lymphoma cells.
Cancer
Science103:375-8 (2012)
Li Z, Yamauchi
Y, Kamakura M, Murayama T, Goshima F, Kimura H, Nishiyama
Y.
Herpes
simplex virus requires PARP activity for efficient replication
and induces ERK-dependent phosphorylation and ICP0-dependent nuclear
localization of tankyrase 1.
Journal
of Virology 86: 492-503
(2012)
Luo C,
Goshima F, Kamakura M, Mutoh Y, Iwata S, Kimura H, Nishiyama Y.
Immunization
with a highly attenuated replication-competent herpes simplex
virus type 1 mutant, HF10, protects mice from genital disease
caused by herpes simplex virus type 2.
Frontiers
in Microbiology 3: 158,
(2012)
Higashimoto
Y, Ohta A, Nishiyama Y , Ihira M, Sugata K, Asano Y, Peterson
DL, Ablashi DV, Lusso P, Yoshikawa T.
Development
of a human herpesvirus 6 species-specific immunoblotting assay.
Journal
of Clinical Microbiology 50:1245-51
(2012)
Sahin TT,
Kasuya H, Nomura N, Shikano T, Yamamura K, Gewen T, Kanzaki A,
Fujii T, Sugae T, Imai T, Nomoto S, Takeda S, Sugimoto H, Kikumori
T, Kodera Y, Nishiyama Y , Nakao A. Impact of novel oncolytic virus HF10 on
cellular components of the tumor microenviroment in patients with
recurrent breast cancer.
Cancer
Gene Therapy 19:229-37 (2012)
Yamaguchi M, Kwong YL, Kim
WS, Maeda Y, Hashimoto C, Suh C, Izutsu K, Ishida F, Isobe Y,
Suzumiya J, Kodama T, Kimura H, Hyo R, Nakamura S, Oshimi K, Suzuki
R.
Phase
II study of SMILE chemotherapy for newly-diagnosed stage IV, relapsed
or refractory extranodal NK/T-cell lymphoma, nasal type: the NK-cell
Tumor Study Group (NKTSG) study.
Journal
of Clinical Oncology 29:
4410-4416 (2011)
Takahashi
E, Ohshima K, Kimura H, Hara K, Suzuki R, Kawa K, Eimoto T, Nakamura
S.
Clinicopathological
analysis of the age-related differences in patients with Epstein-Barr
virus-associated extranasal NK/T-cell lymphoma with reference
to the relationship with aggressive NK cell leukemia and chronic
active Epstein-Barr virus
infection-associated lymphoproliferative
disorder.
Histopathology 59:660-671 (2011)
Esaki
S, Kitoh J, Katsumi S, Goshima F, Kimura H, Sawat M, Yamao K,
Watanabe N, Nonoguchi N, Nakamura T, Coffin RS, Miyatake S, Nishiyama
Y, Murakami S.
Hepatocyte
growth factor incorporated into herpes simplex virus vector accelerates
facial nerve regeneration after crush injury.
Gene
Therapy 11:1063-1069 (2011)
Gotoh K, Ito Y, Maruo S,
Takada K, Mizuno T, Teranishi M, Nakata S, Nakashima T, Iwata
S, Goshima F, Nakamura S, Kimura H.
Replication
of Epstein-Barr virus primary infection in human tonsil tissue
explants.
PLoS
One 6: e25490 (2011).
Kamakura
M, Goshima F, Luo C, Kimura H, Nishiyama Y.
Herpes
simplex virus induces the marked up-regulation of the zinc finger
transcriptional factor INSM1, which modulates the expression and
localization of the immediate early protein ICP0.
Virology
Journal 8:257 (2011).
Ito Y, Kawabe S, Kojima S, Nakamura
F, Nishiyama Y, Kaneko K, Kiuchi K, Ando H, Kimura H.
Identification
of Epstein-Barr virus-infected CD27+ memory B cells in patients
after transplantation.
Journal
of General Virology 92:2590-5
(2011).
Ito Y, Torii Y, Ohta R,
Imai M, Hara S, Kawano Y, Matsubayashi T, Inui A, Yoshikawa T,
Nishimura N, Ozaki T, Morishima T, Kimura H.
Increased
levels of cytokines and high-mobility group box 1 are associated
with the development of severe pneumonia, but not acute encephalopathy,
in 2009 H1N1 influenza-infected children.
Cytokine 56: 180-187 (2011).
Nakamura
M, Iwata S, Kimura H, TokuraY.
Elevated
expression of activation-induced cytidine deaminase in T and NK
cells from patients with chronic active Epstein-Barr virus infection.
Europen
Jounral of Dermatology 21:780-2
(2011).
Gotoh K, Ito Y, Suzuki E,
Kaneko K, Kiuchi T, Ando H, Kimura H.
Effectiveness
and safety of inactivated influenza vaccination in pediatric liver
transplant recipients over three influenza seasons.
Pediatr
Transplant 15: 112-116,
2011
Hayashi
S, Kimura H, Oshiro M, Kato Y, Yasuda A, Suzuki C, Watanabe Y,
Morishima T, Hayakawa M.
Transmission
of cytomegalovirus via breast milk in extremely premature infants.
J
Perinatol 31:440-445, 2011
Hoshino
Y, Nishikawa K, Ito Y, Kuzushima K, Kimura H.
Kinetics
of EpsteinﾐBarr
Virus Load and Virus-Specific CD8+ T Cells in Acute Infectious
Mononucleosis.
Journal
of Clinical Virology 50:
244-246, 2011
Torii
Y, Kimura H, Gotoh K, Ochi N, Kaneko K, Ando H, Kiuchi T, Ito
Y.
Immunogenicity
of inactivated 2009 H1N1 influenza vaccine in pediatric liver
transplant recipients.
Vaccine 29: 4187-9, 2011
Kunitomi
A, Kimura H, Ito Y, Naitoh K, Noda N, Iida H, Sao H.
Unrelated
bone marrow transplantation induced long-term remission in a patient
with life-threatening epstein-barr virus-associated hemophagocytic
lymphohistiocytosis.
J
Clin Exp Hematop 51:57-61,
2011
Ohta A, Yamauchi Y, Muto
Y, Kimura H, Nishiyama Y. Herpes simplex virus type 1 UL14
tegument protein regulates intracellular compartmentalization
of major tegument protein VP16.
Virology
Journal .26:365 (2011)
Iwata S,
Yano S, Ito Y, Ushijima Y, Gotoh K, Kawada JI, Fujiwara S, Sugimoto
K, Isobe Y, Nishiyama Y, Kimura H.
Bortezomib
induces apoptosis in T lymphoma cells and natural killer lymphoma
cells independent of epstein-barr virus infection.
International
Journal of Cancer 129: 2263-2273
(2011).
Esaki S,
Goshima F, Kimura H, Ikeda S, Katsumi S, Kabaya K, Watanabe N,
Hashiba M, Nishiyama Y, Murakami S.:
Auditory
and vestibular defects induced by experimental labyrinthitis following
herpes simplex virus in mice.
Acta Oto-Laryngologica,131:684-91 (2011).
Nakao A,
Kasuya H, Sahin TT, Nomura N, Kanzaki A, Misawa M, Shirota T,
Yamada S, Fujii T, Sugimoto H, Shikano T, Nomoto S, Takeda S,
Kodera Y, Nishiyama Y.
A phase I dose-escalation clinical
trial of intraoperative direct intratumoral injection of HF10
oncolytic virus in non-resectable patients with advanced pancreatic
cancer.
Cancer
Gene Therapy : 18: 167-175(2011).
Ohta
A, Nishiyama Y.
Mitochondria
and viruses.
Mitochondrion.
2011 Jan;11(1):1-12. Epub
2010 Sep 8.
【2010年】
Kawabe S, Ito Y,
Ohta R, Sofue A, Gotoh K, Morishima T, Kimura H.
Comparison
of the cerebrospinal fluid levels and serum concentrations of
human herpesvirus 6 (HHV-6) DNA and cytokines in children with
HHV-6 encephalopathy.
Journal
of Medical Virology 82:1410-1415
(2010)
Ito
Y, Takakura S, Ichiyama S, Ueda M, Ando Y, Matsuda K, Hidaka E,
Nakatani A, ishioka J, Nobori T, Sasaki M, Kimura H. Multicenter
evaluation of prototype real-time PCR assays for Epstein-Barr virus
and cytomegalovirus DNA in whole blood samples from transplant
recipients.
Microbiology
and Immunology 54:516-22
(2010)
Calatini
S, Sereti I, Scheinberg P, Kimura H, Childs R, Cohen JI.
Detection
of EBV genomes in plasmablasts/plasma cells and non-B cells in
the blood of most patients with EBV lymphoproliferative disorders
using Immuno-FISH.
Blood
116:4546-59 (2010)
Esaki,
S., Goshima, F., Katsumi, S., Watanabe, D., Ozaki, N., Murakami,
S., Nishiyama, Y.
Apoptosis
induction after herpes simplex virus infection differs according
to cell type in vivo.
Archieves
of Virology, 155:
1235-1245 (2010).
Fujiwara,
S., Nawa, A., Luo, CH., Kamakura, M., Goshima, F., Kondo, C.,
Kiyono, T., Kikkawa, F., Nishiyama, Y.
Carrier
cell-based delivery of replication- competent HSV-1 mutants enhances
antitumor effect for ovarian cancer.
Cancer
Gene Therapy, 18: 77-86
(2010).
Gotoh,
K., Ito, Y., Iwata, S., Nishiyaa, Y., Nakamura, T., Kaneko, K.,
Kiuchi, T., Ando, H., Kimura, H.
Immunologic
and virologic analyses in pediatric liver transplant recipients
with chronic high Epstein-Barr virus loads.
Journal
of Infectious Disease 202:
461-469 (2010).
Ushijima
Y, Luo C, Kamakura M, Goshima F, Kimura H, Nishiyama Y.
Herpes
simplex virus UL56 interacts with and regulates the Nedd4-family
ubiquitin ligase Itch.
Virology
Journal. 2010 Aug 3;7(1):179.
Iwata,
S., Wada, K., Tobita, S., Gotoh, K., Ito, Y., Demachi-Okamura,
A., Shimizu, N., Nishiyama, Y., and Kimura, H.
Quantitative analysis of
Epstein-Barr virus (EBV)-related gene expression in patients with
chronic active EBV infection.
Journal
of General Virology 91:
42-50 (2010).
Ishida,
D., Nawa, A., Tanino, T., Goshima, F., Luo, C. H., Iwaki, M.,
Kajiyama, H., Shibata, K., Yamamoto, E., Ino, K., Tsurumi, T.,
Nishiyama, Y., and Kikkawa, F.
Enhanced
cytotoxicity with a novel system combining the paclitaxel-2ﾕ-ethylcarbonate produrug
and an HSV amplicon with attenuated replication-competent virus,
HF10 as a helper virus.
Cancer
Letters 288: 17-27 (2010).
Funahashi,
Y., Iwata, S., Ito, Y., Kojima, S., Yoshikawa, T., Hattori,R.,
Gotoh, M., Nishiyama, Y., and Kimura, H.
Multiplex
real-time PCR assay for quantifying BK polyomavirus, JC polyomavirus,
and adenovirus DNA simultaneously.
Journal of Clinical Microbiology 48: 825-30 (2010).
【2009年】
Kimura, H., Miyake, K., Yamauchi, Y., Nishiyama, K., Iwata, S., Iwatsuki, K., Gotoh, K., Kojima, S., Ito, Y., and Nishiyama, Y.
Identification of Epstein-Barr virus-infected lymphocyre subtypes by flow cytometric in situ hybridization in EBV-associated lymphoproliferative diseases.
Journal of Infectious Diseases 200:1078-1087 (2009).
Nomura Y, Kimura H, Karube K, Yoshida S, Sugita Y, Niino D, Shimizu K, Kimura Y, Aoki R, Kiyasu J, Takeuchi M, Hashikawa K, Hirose S, Ohshima K.
Hepatocellular apoptosis associated with cytotoxic T/naturalkiller-cell infiltration in chronic active EBV infection.
Pathol Int 59: 438ﾐ442 (2009)
Ito Y, Shibata-Watanabe Y, Kawada J, Maruyama K, Yagasaki H, Kojima S, Kimura H.
Cytomegalovirus and EpsteinﾐBarr virus coinfection in three toddlers with prolonged illness.
Journal of Medical Virology 81:1399-1402 (2009)
Tanaka-Kitajima N, Iwata N, Ando Y, Sakurai H, Iwami M, Tsuzuki K, Kondo M, Ito Y, Kimura H.
Acute retinal necrosis caused by herpes simplex virus type 2 in a 3- year-old Japanese boy.
Eur J Pediatr 168:1125-28 (2009)
Morimoto, T., Arii, J., Tanaka, M., Sata, T., Akashi, H., Yamada, M., Nishiyama, Y., Uema, M., and Kawaguchi, Y.
Differences in the regulatory and functional effects of the US3 protein kinase activities of herpes simplex virus 1 and 2.
Journal of Virology 83: 11624-11634 (2009).
Ishikawa,
T., Yamada, H., Oyamada, A., Goshima, F., Nishiyama, Y., and Yoshikai,
Y.
Protective
role of Fas-FasL signaling in lethal infection with herpes simplex
virus type 2 in mice.
Journal
of Virology 83: 11777-11783
(2009).
Ushijima,
Y., Goshima, F., Kimura, H. and Nishiyama, Y.
Herpes
simplex virus type 2 tegument protein UL56 relocalizes ubiquitin
ligase Nedd4 and has a role in transport and/or release of virions.
Virology
Journal 16; 6: 168(2009).
Sato Y,
Kamura T, Shirata N, Murata T, Kudoh A, Iwahori S, Nakayama S,
Isomura H, Nishiyama Y, Tsurumi T.
Degradation
of Phosphorylated p53 by Viral Protein-ECS E3 Ligase Complex.
PLoS
Pathog . 2009 Jul;5(7):e1000530.
Epub 2009 Jul 31.
Sato Y, Shirata N, Kudoh A, Iwahori S, Nakayama S, Murata T, Isomura H, Nishiyama Y, Tsurumi T.
Expression of Epstein-Barr virus BZLF1 immediate-early protein induces p53 degradation independent of MDM2, leading to repression of p53-mediated transcription.
Virology 388(1):204-211(2009).Wada K, Mizoguchi S, Ito Y, Kawada J, Yamauchi Y, Morishima T, Nishiyama Y, Kimura H.
Multiplex real-time PCR for the simultaneous detection of herpes simplex virus, human herpesvirus 6, and human herpesvirus 7.
Microbiol Immunol 53(1):22-29 (2009).Mizuno T, Sugiura S, Kimura H, Ando Y, Sone M, Nishiyama Y, Nakashima T.
Detection of cytomegalovirus DNA in preserved umbilical cords from patients with sensorineural hearing loss.
Eur Arch Otorhinolaryngol 266 (3):351-355 (2009).Funahashi Y, Hattori R, Kinukawa T, Kimura H, Nishiyama Y, Gotoh M.
Conversion from mycophenolate mofetil to mizoribine for patients with positive polyomavirus type BK in urine.
Transplant Proc 40 (7): 2268-2270 (2008).Nawa A, Luo C, Zhang L, Ushjima Y, Ishida D, Kamakura M, Fujimoto Y, Goshima F, Kikkawa F, Nishiyama Y.
Non-engineered, naturally oncolytic herpes simplex virus HSV1 HF-10: applications for cancer gene therapy.
Curr Gene Ther 8: 208-221 (2008).Kimura H, Ito Y, Suzuki R, Nishiyama Y.
Measuring Epstein-Barr virus (EBV) load: the significance and application for each EBV-associated disease.
Rev Med Virol 18 : 305-319 (2008).Yamauchi, Y., Kiriyama, K., Kimura, H. and Nishiyama, Y.
Herpes Simplex Virus Induces Extensive Modification and Dynamic Relocalisation of the Nuclear Mitotic Apparatus Protein (NuMA) in Interphase Cells
Journal of Cell Science 121: 2087-2096 (2008).
Kato, A., Tanaka, M., Yamamoto, M., Asai, R., Sata, T., Nishiyama, Y. and Kawaguchi, Y.
Identification of a physiological phosphorylation site of the Herpes simplex virus 1-encoded protein kinase Us3 which regulates its optimal catalytic activity in vitro and influences its function in infected cells.
Journal of Virology 82: 6172-6189 (2008).
Ushijima Y, Koshizuka T, Goshima F, Kimura H, Nishiyama Y.
Herpes Simplex Virus Type 2 UL56 Interacts with the Ubiquitin Ligase Nedd4 and Increases its Ubiquitination.
Journal of Virology 82: 5220-5233 (2008).
Kamakura, M., Nawa, A., Ushijima, Y., Goshima, F., Kawaguchi, Y., Kikkawa, F., Nishiyama, Y. Microarray analysis of transcriptional responses to infection by herpes simplex virus types 1 and 2 and their US3-deficient mutants
Microbes and Infection 10: 405-413 (2008).Watanabe, D., Goshima, F., Mori, I., Tanada, Y., Matsumoto, Y., Nishiyama, Y. Oncolytic viral therapy for malignant melanoma with herpes simplex virus type 1 mutant HF10.
Journal of Dermatological Science 50: 185-196 (2008).
Gotoh K, Ito Y, Shibata-Watanabe Y, Kawada J, Takahashi Y, Yagasaki H, Kojima S, Nishiyama Y, Kimura H. Clinical and virologic characteristics of 15 patients with chronic active EpsteinﾐBarr virus infection treated with hematopoietic stem cell transplantation
Clinical Infectious Disease 46: 1525-1534 (2008).Ito Y, Shibata-Watanabe Y, Ushijima Y, Kawada J, Nishiyama Y, Kojima S, Kimura H. Oligonucleotide Microarray Analysis of Gene Expression Profiles followed by a Real-time RT-PCR Assay in Chronic Active Epstein-Barr Virus Infection.
Journal of Infectious Disease 197: 663-666 (2008).Yamauchi Y, Kiriyama K, Kubota N, Kimura H, Usukura J, Nishiyama Y. The UL14 Tegument Protein of Herpes Simplex Virus Type 1 (HSV-1) is Required for Efficient Nuclear Transport of the Alpha Transinducing Factor VP16 and Viral Capsids.
Journal of Virology 82: 1094-1106 (2008).Nawa, A., Tanino, T., Luo, C., Iwaki, M., Kajiyama, H., Shibata, K., Ino, K., Nishiyama, Y. and Kikkawa, F.
Gene directed enzyme prodrug therapy for ovarian cancer. ﾐ Could GDPET become a promising treatment against ovarian cancer?
Anti-Cancer Agents in Medical Chemisyry, 8：232-239 (2008).
Kagimoto, T., Yamada, H., Ishikawa, T., Maeda, N., Goshima, F., Nishiyama, Y., Furue, M., Yoshikai, Y. A regulatory role of interleukin 15 in wound healing and mucosal in1.
Journal of Leukocyte Biology, 83: 165-172 (2008).
Kubota, N., Wada, K., Ito, Y., Shimoyama, Y., Nakamura, S., Nishiyama, Y., and Kimura, H. One-step multiplex real-time PCR assay to analyse the latency patterns of Epstein-Barr virus infection.
Journal of Virological Methods, 147: 26-36 (2008).
Koshizuka, T., Kawaguchi, Y., Nozawa, N., Mori, I. and Nishiyama, Y. Herpes simplex virus protein UL11 but not UL51 is associated with lipid rafts.
Virus Genes, 35: 571-575 (2007).
Luo, C., Mori, I., Goshima, F., Ushijima, Y., Nawa, A., Kimura, H., Nishiyama, Y.
Replication-competent, oncolytic herpes simplex virus type 1 mutants induce a bystander effect following ganciclovir treatment.
Journal of Gene Medicine 9: 875-883(2007).
Kimura, H. and Nishiyama, Y. Measles Outbreak in Adolescent.
JMA Journal ,in press.Kohno, S., Luo, C., Nawa, A., Fujimoto, Y., Waranabe, D., Goshima, F., Tsurumi, T. and Nishiyama, Y.
Oncolytic Virotherapy with an HSV amplicon vector expressing granulocyte-macrophage colony-stimulating factor using the replication-competent HSV type I mutant HF10 as a helper
Cancer Gene Therapy, 14: 918-926 (2007).
Shimoyama, S., Goshima, F., Teshigahara, O., Kasuya, H., Kodera, Y., Nakao, A. and Nishiyama, Y.
Enhanced efficacy of herpes simplex virus mutant HF10 combined with paclitaxel in peritoneal cancer dissemination models.
Hepato-Gastroenterology, 54: 1038-1042 (2007).Wada, K., Kubota, N., Ito, Y., Yagasaki, H., Kato, K., Yoshikawa, T., Ono, Y., Ando, H., Fujimoto, Y., Kiuchi, T., Kojima, S., Nishiyama, Y. and Kimura H.
Simultaneous quantification of Epstein-Barr virus, Cytomegalovirus, and human Herpesvirus 6 DNA in transplant recipients by multiplex real-time PCR assay.
Journal of Clinical Microbiology 45: 1426-1432 (2007).Kasuya, H.,Nishiyama, Y., Nomoto, S., Goshima, F., Takeda, S., Watanabe, I., Nomura, N., Shikano, T., Fujii, T., Kanazumi, N. and Nakao, A.
Suitability of a US3-inactivated HSV mutant(L1BR1) as an oncolytic-virus for pancreatic cancer therpay.
Cancer Gene Therapy 14: 533-542 (2007).
Tanino T, Nawa A, Kondo, E, Kikkawa F, Daikoku T, Tsurumi T, Luo C, Nishiyama Y, Takayanagi Y, Nishimori K, Miki Y and Iwaki M.
Paclitaxel-2ﾕ-ethylcarbonate prodrug can overcome P-glycoprotein-mediated multidrug resistance to increase drug cytotoxicity.
Pharmaceertical Research(PHARM RES), 24: 555-565 (2007)..
Nakao, A., Takeda, S., Shimoyama, S., Kasuya, H., Kimata, H., Teshigahara, O., Sawaki, M., Kikumori, T., Kodera, Y., Nagasaka, T., Goshima, F., Nishiyama, Y. and Imai, T.
Clinical experiment of mutant herpes simplex virus HF10 therapy for cancer.
Curr Cancer Drug Targets 7: 169-174 (2007).Luo, C., Nawa, A., Yamauchi, Y., Kohno, S., Ushijima, Y., Goshima, F. and Nishiyama, Y.
Intercellular trafficking and cytotoxicity of recombinant HSV-1 thymidine kinase fused with HSV-2 US11 RXP repeat peptide.
Virus Genes 34: 263-272 (2007).
Hattori J, Okumura N, Yamazaki Y, Uchiyama M, Hamaguchi M, Nishiyama Y, Kaneda T.
Beneficial Effect of GB Virus C Co-Infection in Human Immunodeficiency Virus Type 1-Infected Individuals.
Microbiology and Immunology 51(2): 193-200 (2007).Ushijima Y, Luo C, Goshima F, Yamauchi Y, Kimura H, Nishiyama Y.
Determination and analysis of the DNA sequence of highly attenuated herpes simplex virus type 1 mutant HF10, a potential oncolytic virus.
Microbes and Infection 9: 142-149 (2007).
Mori, I. and Nishiyama, Y.
Replication-competent herpes simplex virus: a novel and promising modality for cancer therapy.
Current Topics in Virology, 5: 21-30 (2006).Iwata S, Shibata Y, Kawada J, Hara S, Nishiyama Y, Morishima T, Ihira M, Yoshikawa T, Asano Y, Kimura H.
Rapid detection of Epstein-Barr virus DNA by loop-mediated isothermal amplification method.
Journal of Clinical Virology.37: 128-133 (2006).Sato Y, Tsuboi T, Mikami T, Kurosawa H, Kanou K, Sugita K, Kimura H, Nagasaka T, Imashyuku S, Eguchi M.Chronic active Epstein-Barr virus infection with dilatation of the Valsalva sinus.
Pediatr Int 48:643-5 (2006).
Zhang L, Daikoku T, Ohtake K, Ohtsuka J, Nawa A, Kudoh A, Iwahori S, Isomura H, Nishiyama Y, Tsurumi T. Establishment of a novel foreign gene delivery system combining an HSV amplicon with an attenuated replication-competent virus, HSV-1 HF10.
Journal of Virological Methods 137:177-83 (2006).
Kimata, H., Imai, T., Kikumori, T., Teshigawara, O., Nagasaka, T., Goshima, F., Nishiyama, Y and Nakao, A.
Pilot study of oncolytic viral therapy using mutant herpes simplex virus HF10 against recurrent metastatic breast cancer.
Annals of Surgical Oncology 13: 1078-1084 (2006).
Fujimoto, Y., Mizuno, T., Sugiura, S., Goshima, F., Kohno, S., Nakashima, T. and Nishiyama, Y.
Intratumoral injection of herpes simplex virus HF10 in recurrent head and neck squamous cell carcinoma.
Acta Oto-Laryngologia 126: 1115-1117 (2006).Mori, I., Goshima, F., Watanabe, D., Ito, H., Koide, N., Yoshida, T., Liu, B., Kimura, Y., Yokochi, T. and Nishiyama, Y.
Herpes simplex virus US3 protein kinase regulates virus-induced apoptosis in olfactory and vomeronasal chemosensory neurons in vivo.
Microbes and infection 8:1806-1812 (2006).Mori, I. and Nishiyama, Y.
Accessory genes define the relationship between the herpes simplex virus and its host.
Microbes and Infection 8: 2556-2562 (2006).Kimura H. Pathogenesis of chronic active Epstein-Barr virus infection: Is this an infectious disease, lymphoproliferative disorder, or immunodeficiency?
Reviews in Medical Virology 21: (2006).
Kawada J, Kimura H, Kamachi Y, Nishikawa K, Taniguchi M, Nagaoka K, Kurahashi H, Kojima S, Morishima T. Analysis of gene-expression profiles by oligonucleotide microarray in children with influenza.
Journal of General Virology 87:1677-83, (2006).
Maeda N, Yamashita Y, Kimura H, Hara S, Mori N.
Quantitative analysis of herpesvirus load in the lymph nodes of patients with histiocytic necrotizing lymphadenitis using a real-time PCR assay.
Diagnostic Molecular Pathology 15 :49-55 (2006).Shibata, Y., Hoshino, Y., Hara, S., Yagasaki, H., Kojima, S., Nishiyama, Y., Morishima, T. and Kimura, H.
Clonality analysis by sequence variation of the latent membrane protein 1 gene in patients with chronic active Epstein-Barr virus infection.
Journal of Medical Virology 78:770-779 (2006).
Asai, R., Kato, A., Kato, K., Kanamori-Koyama, M., Sugimoto, K., Sairenji, T., Nishiyama, Y. and Kawaguchi, Y.
Epstein-barr virus protein kinase BGLF4 is a virion tegument protein that dissociates from virions in a phosphorylation dependent process and phosphorylates the viral innediate-early protein BZLF1.
Journal of Virology 80: 5125-5134 (2006).
Koshizuka, T., Kawaguchi, Y., Goshima, F., Mori, I. and Nishiyama, Y.
Association of two membrane proteins encoded by herpes simplex virus type2, UL11 and UL56.
Virus Genes 32,157-167 (2006).Kato, A., Yamamoto, M., Ohno, T., Tanaka, M., Sata, T., Nishiyama,Y., and Kawaguchi, Y. Herpes simplex virus 1-encoded protein kinase UL13 phosphorylates the viral US3 protein kinase and regulates nuclear localization of viral envelopment factors UL34 and UL31.
Journal of Virology 80:1476-1486 (2006).
Miyake, F., Yoshikawa, T., Sun, H., Kakimi, A., Ohashi, M., Akimoto, S., Nishiyama, Y., Asano, Y. Latent infection of human herpesvirus 7 in CD4(+)T lymphocytes.
Journal of Medical Virology 78:112-116 (2006).
Kohno, S., Luo, C., Goshima, F., Nishiyama, Y., Sata, T. and Ono, Y.
Herpes simplex virus type 1 mutant HF10 oncolytic virutherapy for bladder cancer.
Urology 66:1116-1121 (2005).
Tanaka, M., Nishiyama, Y., Sata, T. and Kawaguchi , Y.
The role of protein kinase activity expressed by the UL13 gene of herpes simplex virus 1: the activity is not essential for optimal expression of ICP0 and UL41.
Virology 341: 301-312 (2005).
Mori, I., Goshima, F., Mizuno, T., Imai, Y., Kohsaka, S., Ito, H., Koide, N., Yoshida, T., Kimura, Y., Yokochi, T. and Nishiyama, Y.
Axonal injury in experimental herpes simplex encephalitis.
Brain Research 1057:186-190 (2005).Mori, I. and Nishiyama, Y.
Herpes simplex virus and varicella-zoster virus: why do these human alphaherpesviruses behave so differently?
Reviews in Medical Virology 15:393-406 (2005).Mori, I., Liu, B., Goshima, F., Ito, H., Koide, N., Yoshida, T., Yokochi, T., Kimura Y. and Nishiyama, Y.
HF10, an attenuated herpes simplex virus (HSV) type 1 clone, lacks neuroinvasiveness and protects mice against lethal challenge with HSV types 1 and 2.
Microbes and Infection 26; [Epub ahead of print] (2005).
Kato, A., Yamamoto, M., Ohno, T., Kodaira, H., Nishiyama, Y. and Kawaguchi, Y.
Identification of proteins phosphorylated directly by the US3 protein kinase encoded by herpes simplex virus 1.
Journal of Virology 79 :9325-31 (2005).Mori, I., Nishiyama, Y., Yokochi, T. and Kimura, Y.
Olfactory transmission of neurotropic viruses.
Journal of NeuroVirology 11:129-37 (2005).Shaku, F., Matsuda, G., Furuya, R., Kamagata, C., Igarashi, M., Tanaka, M., Kanamori, M., Nishiyama, Y., Yamamoto, N. and Kawaguchi, Y.
Development of a monoclonal antibody against Epstein-Barr virus nuclear anti gen leader protein (EBNA-LP) that can detect EBNA-LP expressed in P3HR1 cells.
Microbiology and Immunology 49: 477-483 (2005).
Matsuzaki, A., Yamauchi, Y., Kato, A., Goshima, F., Kawaguchi, Y., Yoshikawa, T. and Nishiyama, Y.
The US3 protein kinase of herpes simplex virus type 2 is required for the stability of the UL46-encoded tegument protein and its association with virus particles.
Journal of General Virology 86: 1979-1985 (2005).
Mori, I., Koshizuka, T., Goshima, F., Ito, H., Koide, N., Yoshida, T., Yokochi, T., Kimura, Y. and Nishiyama Y.
Herpes simplex virus US11 shows intercellular trafficking activity in the mouse brain.
Molecular Brain Research 136: 158-163 (2005).Nozawa, N., Kawaguchi, Y., Tanaka, M., Kato, A., Kato, A., Kimura, H. and Nishiyama, Y.
Herpes simplex virus type 1 UL51 protein is involved in maturation and egress of virus particles.
Journal of Virology, 79: 6947-6956 (2005).Mori, I., Goshima, F., Ito, H.,Koide, N.,Yoshida, T.,Yokochi, T.,Kimura, Y. and Nishiyama, Y. The vomeronasal chemosensory system as a potent route of neuroinvasion by herpes simplex virus.
Virology 334: 51-58 (2005).
Kudoh, A., Fujita, M., Zhan, L., Shirata, N., Daikoku, T., Sugaya, Y., Isomura, H., Nishiyama, Y. and Turumi, T.
Epstein-Barr virus lytic replication elicits ATM checkpoint signal transduction while providing an S-phase-like cellular environment.
Journal of Biological Chemistry 280: 8156-8163 (2005).
Koshizuka, T., Kawaguchi, Y. and Nishiyama, Y.
Herpes simplex virus type 2 membrane protein UL56 associates with the kinesin motor protein KIFIA.
Journal of General Virology 86: 527-533 (2005).Enomoto, Y., Yoshikawa, T., Ihira, M., Akimoto, S., Miyake F., Usui, C., Suga, S., Suzuki, K., Kawana T., Nishiyama, Y. and Asano, Y.
Rapid Diagnosis of herpes simplex virus infection by a loop-mediated isothermal amplification method.
Journal of Clinical Microbiology 43: 951-955 (2005).Nagai, H., Wada K., Morishita, T., Utsumi, M., Nishiyama, Y. and Kaneda, T.
New estimation method for highly sensitive quantitation of human immunodeficiency virus type 1 DNA and its application.
Journal of Virological Methods 124: 157-165 (2005).
Yamamoto, K., Yoshikawa, T., Okamoto, S., Yamaki, K., Shimokata, K. and Nishiyama, Y.
HHV-6 and 7 DNA loads in lung tissues collected from patients with interstitial pneumonia.
Journal of Medical Virology , 75: 70-75 (2005).
Nishimura, N., Yoshikawa, T., Ozaki, T., Sun, H., Goshima, F., Nishiyama, Y., Asano, Y., Kurata, T and Iwasaki, T.
In vitro and in vitro analysis of human herpes ﾐ6 U90 protein expression.
Journal of Medical Virology, 75: 86-92 (2005).
【2004年】
Ohashi, M., Yoshikawa, T., Asonuma, K., Iwasaki, T., Nishiyama, Y., Asano, Y., Kimoto, Y., Yagi, T., Urushihara, N., Tanaka N. and Baba, K.
Human herpesvirus 6 fulminant hepatic failure treated by living donor liver transplantation.
Pediatrics International 46: 730-732 (2004).
Okamoto, S., Yoshikawa, T., Ihira, M., Suzuki, K., Shimokata, K., Nishiyama, Y. and Asano, Y. Rapid detection of varicella-zoster virus infection by a loop-mediated isothermal amplification method.
Journal of Medical Virology 74: 677-682 (2004).
Nozawa, N, Yamauchi, Y., Ohtsuka, K., Kawaguchi, Y., and Nishiyama, Y.
Formation of aggresome-like structures in herpes simplex virus type 2-infected cells and a potential role in virus assembly.
Experimental Cell Research 299: 486-497(2004).
Sugiura, S., Yoshikawa, T., Nishiyama, Y., Morishita, Y., Sato, E., Beppu, R., Hattori, T. and Nakashima T.
Detection of herpesvirus DNAs in perilymph obtained from patients with sensorineural hearing loss by real-time polymerase chain reaction.
Laryngoscope 114(12): 2235-2238 (2004).
Mori, I., Nishiyama, Y., Yokochi, T. and Kimura, Y.
Virus-induced neuronal apoptosis as pathological and protective responses of the host.
Reviews in Medical Virology 14: 209-216(2004).
Nakao, A., Kimata, H., Imai, T., Kimumori, T., Teshigahara, O., Nagasaka, T , Goshima, F. and Nishiyama, Y.
Intratumoral injection of herpes simplex HF10 in rexurrent breast cancer.
Annals of Oncology 15: 988-989 (2004).
Tanaka, M., Kodaira, H., Nishiyama, Y., Sata, T., and Kawaguchi, Y.
Construction of recombinant herpes simplex virus type 1 expressing green fluorescent protein without loss of any viral genes.
Microbes and Infection 6: 485-493 (2004).
Mori, I., Kimura, Y., Naiki, H., Matsubara R., Takeuchi, T., Yokochi, T., and Nishiyama, Y. Reactivation of HSV-1 in the brain of patients with familial Alzheimer's disease.
Journal of Medical Virology 73: 605-611 (2004).
Nishimura, H., Yajima, T., Kagimoto, Y., Ohata, M., Watase, T., Kishihara, K., Goshima, F., Nishiyama, Y. and Yoshikai, Y.
Intraepithelial γδ T cells may bridge a gap between innate immunity and acquired immunity to herpes simplex virus type 2.
Journal of Virology 78: 4927-4930 (2004).Kanamori, M., Watanabe, S., Honma, R., Kuroda, M., Imai, S., Yamamoto, N., Nishiyama, Y., and Kawaguchi, Y.
Epstein-Barr virus nuclear antigen leader protein induces expression of thymus and activation-regulated chemokine in B cells.
Journal of Virology 78: 3984-3993 (2004). .
Niimi, A., Limsirichaikul, S., Yoshoda, S., Iwai, S., Masutani, C., Hanaoka, F., Kool, E. T., Nishiyama, Y. and Suzuki, M.
Palm residue mutant in DNA polymerases α and η alter DNA replication fidelity and translesion activity.
Molecular and Cellular Biology 24: 2734-2746 (2004).Mori, I., Yokochi, T., Koide, N., Sugiyama, T., Yoshida, T., Kimura, Y., Naiki, H., Matsubara, R., Takeuchi, T., and Nishiyama, Y.
PCR search for HSV-1 genome in the brain section of patients with familal Alzheimer's disease.
Journal of Clinical Microbiology 42: 936-937 (2004).
Sugiura, S., Goshima, F., Takakuwa, H., Sata, T., Nakashima, T., and Nishiyama, Y. Treatment of solid sarcomas in immunocometent mice with novel oncolytic herpes simplex viruses.
Otolaryngological Head and Neck Surgery 130: 470-478 (2004).Asano, S.,Yoshikawa, T., Kimura, H., Enomoto, Y., Ohashi, M., Terasaki, H. and Nishiyama, Y.
Monitoring herpesvirus DNA in three cases of acute retinal necrosis by real-time PCR.
Journal of Clinical Virology 29: 206-209 (2004).
Yoshikawa, T., Ihira, M., Akimoto, S., Usui, C., Miyake, F., Suga, S., Enomoto, Y., Suzuki, R., Nishiyama, Y. and Asano, Y.
Detection of human herpesvirus 7 DNA by loop-mediated isothermal amplification.
Journal of Clinical Microbiology 42: 1348-1352 (2004).
Suda, N., Ito, Y., Imai, T., Kikumori, T.,Kikuchi, A.,Nishiyama, Y.,Yoshida, S. and Suzuki, M.
The α 4 residues of human DNA topoisomerases II α function in enzymatic activity and anticancer drug sensitivity.
Nucleic Acids Research 32: 1767-1773 (2004).Nishiyama, Y. Herpes simplex virus gene products: the accessories reflect her lifestyle well.
Reviews in Medical Virology 14: 33-46. (2004).
Teshigahara, O., Goshima, F., Takao,K., Kohno, S., Kimata, H., Nakao, A., and Nishiyama, Y.
Oncolytic viral therapy for breast cancer with herpes simplex virus type 1 mutant HF10.
Journal of Surgical Oncology 85: 42-47. (2004).
Ihira, M., Yoshikawa, T., Enomoto, Y., Akimoto, S., Ohashi, M., Suga, S., Nishimura, N., Ozaki, T., Nishiyama, Y., Notomi, T., Ohta ,Y. and Asano, Y.
Rapid diagnosis of human herpesvirus 6 infection by a novel DNA amplification method, Loop-mediated isothermal amplification.
Journal of Clinical Microbiology 42: 140-145. (2004).Kudoh, A., Daikoku,T.,Sugaya, Y., Isomura, T., Fujita, M., Kiyono, T., Nishiyama, Y and Tsurumi, T.
Inhibition of S-phase cyclin-dependent kinase activity blocks expression of Epstein Barr virus immediate early and early genes, preventing viral lytic replication.
Journal of Virology 78:104-115. (2004).
【2003年】
Mori, I., Goshima, F., Koshizuka, T., Imai, Y., Kohsaka, S., Sugiyama, T., Yoshida, T., Yokochi, T., Kimura, Y. and Nishiyama, Y.
Iba 1-expressing microglia-like cells respond to herpes simplex virus infection in the mouse trigeminal ganglion.
Molecular Brain Research120: 52-56. (2003).
Ihira, M., Yoshikawa, T., Ohashi, M., Enomoto, Y., Akimoto, S., Suga, S., Hiroo, S., Nishiyama, Y. and Asano, Y.
Variation of human herpesvirus 7 shedding in saliva.
Journal of Infectious Diseases 188: 1352-1354. (2003).
Mori, I., Goshima, F., Koshizuka, T., Koide, N., Sugiyama, T., Yoshida, T., Tokochi, T., Kimura, Y. and Nishiyama, Y.
The US3 protein kinase of herpes simplx virus attenuates the activation of the JNK signal transduction pathway in infected piriform cortex neurons in C57BL/6 mice.
Neuroscience Letters 351: 201-205.(2003).
Kato, K., Yokoyama, A., Tohya, Y., Akashi, H., Nishiyama, Y., and Kawaguchi, Y. Identification of protein kinases responsible for phosphorylation of Epstein-Barr virus nuclear leader protein at serine 35 that regulates its coactivator function.
Journal of General Virology 84: 3381-3382.(2003).
Nawa, A., Nozawa, N., Goshima, F., Nagasaka, T., Kikkawa, F., Niwa, Y., Nakanishi, T., Kuzuya, K. and Nishiyama, Y.
Oncolytic viral therapy for human ovarian cancer using a novel replication-competent herpes simplex virus type 1 mutant in a mouse model.
Gynecological Oncology 91: 81-88.(2003).
Kimura, H., Ito, Y., Futamura, M., Ando, Y., Hara, S., Sobajima, H., Nishiyama, Y., and Morishima, T.
Relapse of neonatal herpes simplex virus infection.
Archives of Disease in Childhood 88: F483-486.(2003).
Yamauchi, Y., Daikoku, T., Goshima, F., and Nishiyama, Y.
Herpes simplex virus UL14 protein blocks apoptosis.
Micribiology and immunology 47: 685-689(2003).
Kawaguchi, Y. and Kato, K.
Protein kinases conserved in herpesviruses potentially share a function mimicking the cellular protein kinase cdc2.
Reviews in Medical Virology 13: 331-340. (2003).Yoshikawa, T., Goshima, F., Akimoto, S., Nishimura, N., Ozaki, T., Iwasaki, T., Kurata, T., Asano, Y. and Nishiyama, Y.
Human herpesvirus 6 infection of human epidermal cell line; pathogenesis of skin manifestations.
Journal of Medical Virology 71: 62-68 (2003).
Mori, I., Goshima, F., Koshizuka, T., Koide, N., Sugiyama, T., Yoshida, T., Yokochi, T., Nishiyama, Y. and Kimura, Y.
Differential activation of JNK/SAPK and p38 MAPK signal transduction pathways in the mouse brain upon infection with neurovirulent influenza A virus.
Journal of General Virology 84: 2401-2408. (2003).Yoshikawa, T., Yoshida, J., Hamaguchi, M., Kubota, T., Akimoto, S., Ihira, M., Nishiyama, Y. and Asano, Y.
Human herpesvirus 7-associated meningitis and optic neuritis in a patient after allogeneic stem cell transplantation.
Journal of Medical Virology 70: 440-443.(2003).Matsuda, G., Nakajima, K. , Kawaguchi, Y., Yamanashi, Y. and Hirai, K.
Epstein-Barr virus (EBV) nuclear antigen leader protein (EBNA-LP) forms complexes with a cellular anti-apoptosis protein bcl-2 or its EBV counterpart BHRF1 through HS1-associated protein X-1.
Microbiology and Immunology 47: 91-99.(2003)Igarashi, M., Kawaguchi, Y., Hirai, K. and Mizuno, F.
Physical interaction of Epstein-Barr Virus (EBV) nuclear antigen leader protein (EBNA-LP) with human estrogen-related receptor 1 (hERR1): hERR1 interacts with a conserved domain of EBNA-LP that is critical for EBV-induced B-cell immortalization.
Journal of General Virology 84: 319-327.(2003)Tanaka, M., Kagawa, H., Yamanashi, Y., Sata, T. and Kawaguchi Y.
Construction of an Excisable Bacterial Artificial Chromosome Containing a Full-Length Infectious Clone of Herpes Simplex Virus Type 1: Viruses Reconstituted from the Clone Exhibits Wild-Type Properties In Vitro and In Vivo.
Journal of Virology 77: 1382-1391. (2003)Yoshikawa, T., Akimoto, S., Nishimura, N., Ozaki, T., Ihira, M., Ohashi, M., Morooka, M., Suga, S., Asano., Takemoto, M., and Nishiyama, Y.
Evaluation of active human herpesvirus 6 infection by reverse transcription-PCR.
Journal of Medical Virology 70: 267-272(2003).Kimata, H., Takakuwa, H., Goshima, F., Teshigawara, O., Nakao, A., Kurata, T.,Sata, T., and Nishiyama, Y.
Effective treatment of disseminated peritoneal colon cancer with new replication-competent herpes simplex viruses.
Hepato-Gastroenterology 50: 961-966(2003).Takakuwa, T., Goshima, F., Nozawa, N., Yoshikawa, T., Kimura, H., Nakao, A., Nawa, A., Kurata, T., Sata, T., and Nishiyama, Y.
Oncolytic viral therapy for peritoneally disseminated tumor using a spontaneously generated herpes simplex virus type 1 variant in immunocompetent mice.
Archives of Virology 148: 813-825(2003).Nozawa, N., Daikoku, T., Koshizuka, T., Yamauchi, Y., Yoshikawa, T., and Nishiyama, Y.
Subcellular localization of UL51 protein of herpes simplex virus type 1 and role of palmitoylation in Golgi targeting.
Journal of Virology 77:3204-3216(2003).Kawaguchi, Y., Kato, K., Tanaka, M., Kanamori., M., Nishiyama, Y., and Yamanashi., Y.
Conserves protein kinases encoded by herpesviruses and a cellular protein kinase cde2 target the same phosphorylation site in eukaryotic elongation factor 1δ.
Journal of Virology 77:2359-2368(2003).Kudoh, A., Fujita, M., Kiyono, T., Kuzushima, K., Sugaya, Y., Izuta, S., Nishiyama, Y., and Tsurumi, T.
Reactivation of lytic replication from Epstein-Barr virus latently infected B-cells occurs with high S-phase CDK activity while inhibiting cellular DNA replication.
Journal of Virology 77:851-861(2003).Sugiura,S.,Yoshikawa, T.,Nishiyama,Y.,Morishita,Y.,Sato,E.,Hattori,T.,and Nakashima,T.
Detection of human cytomegalovirus DNA in perilymph of patients with sensorineural hearing loss using real-time PCR.
Journal of Medical Virology 69:72-75(2003).【2002年】
Tanaka, N.,Kimura, H.,Hoshino, Y.,Nishikawa, K.,Kojima, S.,Nishiyama, Y.and Morishima, Y.
Expression of tegument protein pp65 of human cytomegalovirus(CMV) and its application to the analysis of viral-specific cellular immunity in CMV -infected individuals.
Archives of Virology147: 2405-2417(2002).Mori,I.,Liu,B.,HossainMd,J.,Takakuwa,H.,Daikoku,T.,Nishiyama,Y.,Naiki,H.,Matsumoto,K.,Yokochi,T.,and Kimura,Y.
Successful protection by amantadine hydrochloride against lethal encephalitis caused by a highly neurovirulent recombinant influenza A virus in mice.
Virology 303:287-296(2002).Umemura, M., Nishimura, H., Yajima, T., Wajjwalku, W., Matsuguchi, T., Takahashi, M., Nishiyama, Y., Makino, M., Nagai, Y. and Yoshikai, Y.
Overexpression of interleukin 15 prevents the development of murine retrovirus-induced acquired immunodeficiency syndrome.
The FASEB Journal16:1755-1763(2002).Ihira, M., Yoshikawa, T., Suzuki, K., Ohashi, M., Suga, S., Horibe, K., Tanaka, N., Kimura, H., Kojima, S., Kato, K., Matsuyama, T., Nishiyama, Y. and Asano, Y.
Monitoring of active HHV-6 infection in bone marrow transplant recipients by real time PCR and plasma PCR; comparison to detection of viral DNA in plasma by qualitative PCR.
Microbiology and Immunology 46: 701-705 (2002).Murata, T., Goshima, F., Nishizawa, Y., Daikoku, T., Takakuwa, T., Ohtsuka, K. and Nishiyama, Y.
Phosphorylation of cytokeratin 17 by herpes simplex virus type 2 US3 protein kinase.
Microbiology and Immunology 46: 707-719 (2002).Yamauchi, Y., Goshima, F., Yoshikawa, T., Nozawa, N., Koshizuka, T. and Nishiyama, Y.
Intercellular trafficking of herpes simplex virus type 2 UL14 deletion mutant proteins.
Biochemical and Biophysical Research Communications 298: 357-363 (2002).Murata,T.,Goshima,F.,Takakuwa,H. and Nishiyama,Y.
Excretion of herpes simplex virus type 2 glycoprotein D into culture medium.
Journal of General Virology 83: 2791-2795(2002).Mori,I.,Goshima,F.,Imai,Y.,Kohsaka,S.,Sugiyama,T.,Yoshida,T.,Yokochi,T.,Nishiyama,Y. and Kimura,Y.
Olfactory receptor neurons prevent dissemination of neurovirulent influenza A virus into the brain by undergoing virus-induced apoptosis.
Journal of General Virology 83:2109-2116(2002).Yamauchi,Y.,Wada,K.,Goshima,F.,Daikoku,T.,Ohtsuka,K., and Nishiyama,Y.
Herpes simplex virus type 2 UL14 gene product has heat shock protein (HSP)-like functions.
Journal of Cell Science 115:2517-2527(2002).Koshizuka,T.,Goshima,F.,Takakuwa,H.,Nozawa,N.,Daikoku,T.,Koiwai,O. and Nishiyama,Y.
Identification and characterization of the UL56 gene product of herpes simplex virus type2.
Journal of Virology 76:6718-6728(2002).Murata,T.,Goshima,F.,Yamauchi,Y.,Koshizuka,T.,Takakuwa,H. and Nishiyama,Y.
Herpes simplex virus type 2 US3 blocks apoptosis induced by osmotic shock.
Microbes and Infection 4:707-712(2002).Kimura,H.,Ito,Y.,Futamura,M.,Ando,Y.,Yabuta,Y.,Hoshino,Y.,Nishiyama,Y., and Morishima,T. Quantitation of viral load in neonatal herpes simplex virus infection and comparison between type 1 and type 2.
Journal of Medical Virology 67:349-353(2002).Nozawa,N.,Daikoku,T.,Goshima,F.,Yamauchi,Y.,Takakuwa,H.,Yoshikawa,T., and Nishiyama,Y. Identification and characterization of the UL7 gene product of herpes simplex virus type 2.
Virus Genes 24:257-266(2002).Ihira,M.,Yoshikawa,T.,Ishiji,J.,Ohashi,M.,Enomoto,Y.,Suga,S.,Iida,K.,Saito,Y., Nishiyama,Y., and Asano,Y.
Serological analysis of human herpesvirus 6 and 7 in patients with coronary artery disease.
Journal of Medical Virology 67:534-537(2002).Ohashi,M.,Yoshikawa,T.,Ihira,M.,Suzuki,K.,Enomoto,Y.,Suga,S.,Tada,S.,Sakui,H.,Iida,K., Saito,Y.,Nishiyama,Y. and Asano,Y.
Reactivation of human herpesvirus 6 and 7 in pregnant woman.
Journal of Medical Virology 67:354-358(2002).Nishiyama,Y. and Murata,T. Antiapoptotic protein kinase of herpes simplex virus.
Trends in Microbiology 10:105-107(2002).Yoshikawa,T.,Asano,Y.,Akimoto,S.,Ozaki,T.,Iwasaki,T.,Kurata,T.,Goshima,F.,and Nishiyama,Y.
Latent infection of human herpesvirus 6 in astrocytoma cell line and alteration of cytokine synthesis.
Journal of Medical Virology 66:497-505(2002).Yoshikawa,T.,Asano,Y.,Ihira,M.,Suzuki,K.,Ohashi,M.,Suga,S.,Kuto,K.,Horibe,K.,Kojima,S., Kato,K.,Matsuyama,T. and Nishiyama,Y.
Human herpesvirus 6 viremia in bone marrow transplant recipients:clinical features and risk factors.
Journal of Infectious Disease 185:847-853(2002).Inagaki-Ohara,K.,Kawabe,T.,Hasegawa,N.,Hashimoto,N. and Nishiyama,Y.
Critical involvement of CD40 in protection against herpes simplex virus infection in a murine model of genital herpes.
Archives of Virology 147:187-194(2002).Yoshikawa,T.,Ihira,M.,Asano,Y.,Tomitaka,A.,Suzuki,K.,Matsunaga,K.,Kato.,Hiramitsu,S., Tanaka,N.,Kimura,H. and Nishiyama,Y.
Fatal adult case of severe lymphocytopenia associated with reactivation of human herpesvirus 6.
Journal of Medical Virology 66: 82-85(2002).【2001年】
Koshizuka,T.,Takakuwa,H.,Goshima,F.,Murata,T. and Nishiyama,Y.
The US11 gene product of herpes simplex virus has intercellular trafficking activity.
Biochemical and Biophysical Research Communications 288(3):597-602(2001).Takakuwa, H., Goshima, F., Koshizuka, T., Murata, T., Daikoku, T. and Nishiyama, Y.
Herpes simplex virus encodes a virion-associated protein which promotes long cellular processes in overexpressing cells.
Genes to Cells 6:955-966(2001).Inagaki-Ohara, K., Iwasaki, T., Watanabe, D., Kurata, T., and Nishiyama, Y.
Effect of the deletion of US2 and US3 from herpes simplex virus type 2 on immune responses in the murine vagina following intravaginal infection.
Vaccine 20:98-104(2001).Goshima, F., Watanabe, D., Suzuki, H., Takakuwa, H., Yamada, H. and Nishiyama, Y.
The US2 gene product of herpes simplex virus Type 2 interacts with cytokeratin 18.
Archives of Virology 146:2201-2209(2001).Yoshikawa, T., Ihira, M., Asano, Y., Tomitaka, A., Suzuki, K., Matsunaga, K., Kato., Hiramitsu, S., Tanaka, N., Kimura, H. and Nishiyama, Y.
A fatal adult case of severe lymphocytopenia associated with reactivation of human herpesvirus 6.
Journal of Medical Virology 66:82-85(2002).Yoshikawa, T.,Ihira, M., Ohashi, M., Suga, S., Asano, Y., Miyazaki, H., Hirano, M., Suzuki, K., Matsunaga, K., Horibe, K., Kojima, S., Kudo, K., Kato, K., Matsuyama, T. and Nishiyama, Y.
Correlation between HHV-6 infection and skin rash after allogeneic bone marrow transplantation.
Bone Marrow Transplantation 28:77-81(2001).Ito, Y., Kimura, H., Hara, S., Kido, S., Ozaki, T., Nishiyama, Y. and Morishima, T.
Investigation of varicella-zoster virus DNA in lymphocyte subpopulation by quantitative PCR assay.
Microbiology and Immunology 45:267-269 (2001).Yoshikawa, T., Ihira, M., Suzuki, K., Suga, S., Asano, Y., Asonuma, K., Tanaka, K. and Nishiyama, Y.
Primary human herpesvirus 6 infection in liver transplant recipients.
The Journal of Pediatrics 138:921-925 (2001).Zhu, H.-Y., Murata, T., Goshima, F., Takakuwa, H., Koshizuka, T., Yamauchi, Y. and Nishiyama, Y.
Identification and characterization of the UL24 gene product of herpes simplex virus type 2.
Virus Genes 22:321-327 (2001).Yamauchi, Y., Shiba, C., Goshima, F., Nawa, A., Murata, T. and Nishiyama, Y.
Herpes simplex virus type 2 UL34 protein requires UL31 protein for its relocation to the internal nuclear membrane in transfected cells.
Journal of General Virology 82:1423-1428 (2001).Murata, T., Goshima, F., Takakuwa, H. and Nishiyama, Y.
A single point mutation in the ICP27 gene of herpes simplex virus type 1 is responsible for its resistance to Leptomycin B.
Journal of Virology 75: 1039-1043 (2001)Yamauchi, Y.,Wada, K.,Goshima, F.,Takakuwa, H.,Daikoku, T.,Yamada, M. and Nishiyama, Y.
The UL14 protein of herpes simplex virus type 2 translocates the minor capsid protein and the DNA cleavage and packaging UL33 protein into the nucleus of coexpressing cells.
Journal of General Virology 82: 321-330 (2001).【2000年】
Hoshino, Y., Kimura, H., Kuzushima, K., Tsurumi, T., Nemoto, K., Kikuta, A., Nishiyama, Y., Kojima, S., Matsuyama, T. and Morishima, T.
Early intervension in post-transplant lymphoproliferative disorders based on Epstein-Barr viral load.
Bone Marrow Transplantation 26: 199-201 (2000).Kasuya, H., Mizuno, M., Yoshida, J., Nishiyama, Y., Nomoto, S. and Nakao, A.
Combined effects of adeno-associated virus (AAV) vector and a herpes simplex virus mutant as neoplastic therapy.
Journal of Surgical Oncology 74: 214-218 (2000).Yokoyama, N., Hirata, M., Ohtsuka, K., Nishiyama, Y., Fujii, K., Fujita, M., Kuzushima, K., Kiyono, T. and Tsurumi, T.
Coexpression of human chaperone Hsp70 and Hsdj or Hsp40 cofactor increases solubility of overexpressed target proteins in insect cells.
Biochimica et Biophysica Acta 1493: 119-124 (2000).Tsunobuchi, H., Nishimura, H., Goshima, F, Daikoku, T., Nishiyama, Y. and Yoshikai, Y.
Memory type CD8+ T cells protect IL-2Rα-deficient mice from systemic infection with HSV type 2.
Journal of Immunology 165: 4552-4560 (2000).Watanabe, D., Ushijima, Y., Goshima, F., Takakuwa, H., Tomita, Y. and Nishiyama, Y.
Identification of nuclear export signal in the UL37 protein of herpes simplex virus type 2.
Biochemical and Biophysical Research Communications 276: 1248-1254 (2000)Murata, T., Goshima, F., Daikoku, T., Takakuwa, H. and Nishiyama, Y.
Expression of herpes simplex virus type 2 US3 affects the Cdc/Rac pathway and attenuates c-Jun N-terminal kinase activation.
Genes to Cells 5: 1017-1027 (2000).Asano, S., Honda, T., Goshima, F., Nishiyama, Y. and Sugiura, Y.
US3 protein kinase of herpes simplex virus protects primary afferent neurons from virus-induced apoptosis.
Neuroscience Letters 294: 105-108 (2000).Shiba, C.,Daikoku, T.,Goshima, F.,Takakuwa, H.,Yamauchi, Y.,Koiwai, O. and Nishiyama, Y.
The UL34 gene product of herpes simplex virus type II is a tail-anchored type II membrane protein.
Journal of General Virology 81:2397-2405 (2000).Umemura, M., Wajjwalku, W., Upragarin, N., Liu, T., Nishimura, H., Matsuguchi, T., Nishiyama, Y.,Wilson, M. G. and Yoshikai, Y.
Expression of mouse mammary tumor virus superantigen accelerates tumorigenicity of myeloma cells.
Journal of Virology74:8226-8233 (2000).Inagaki, -O. K., Daikoku, T., Goshima, F. and Nishiyama, Y.
Impaired induction of protective immunity by highly virulent herpes simplex virus type 2 in a murine model of genital herpes.
Archives of Virology145:1989-2002 (2000).Tsunobuchi, H., Nishimura, H., Goshima, F., Daikoku, T., Suzuki, H., Nakashima, I., Nishiyama, Y. and Yoshikai, Y.
A protective role of interleukin-15 in a mouse model for systematic infection with herpes simplex virus.
Virology275:57-66 (2000).Watanabe, D., Honda, T., Nishio, K., Tomita, Y., Sugiura, Y. and Nishiyama, Y.
Corneal infection of herpes simplex virus type-2 induced neuronal apoptosis in the brain stem of mice with expression of tumor suppressor gene (p53) and transcription factors.
Acta Neuropathologica100:647-653 (2000).
Kato, K., Daikoku, T., Goshima, F., Kume, H., Yamaki, K. and Nishiyama, Y.
Synthesis, subcellular localization and VP16 interaction of the herpes simplex virus type 2 UL46 gene product.
Archives of Virology145:2149-2162 (2000).Kasuya, H., Nakao, A., Nishiyama, Y., Takagi, H., Mizuno, M. and Yoshida, J.
A new strategy for gene therapy: transduction of adeno-associated virus (AAV) vector is enhanced by mixed infection with recombinant herpes simplex virus (ICP6 Δ).
Journal of Surgical Oncology 74:214-218 (2000).Kimura, H., Nishikawa, K., Hoshino, Y., Sofue, A., Nishiyama, Y. and Morishima, T. Monitoring of cell-free viral DNA in primary Epstein-Barr virus infection.
Medical Microbiology and Immunology 188: 197-202 (2000).Suzutani, T., Nagamine, M., Shibaki, T., Ogasawara, M., Yoshida, I., Daikoku, T., Nishiyama, Y. and Azuma, M.
The role of the UL41 gene of herpes simplex virus type 1 in evasion of non-specific host defence mechanisms during primary infection.
Journal of General Virology 81: 1763-1771 (2000).Hasegawa, Y., Nishiyama, Y., Imaizumi, K., Ono, N., Kinoshita, T., Hatano, S., Saito, H. and Shimokata, K.
Avoidance of bone marrow suppression using A-5021 as a nucleoside analog for retrovirus-mediated herpes simplex virus type 1 thymidine kinase gene therapy.
Cancer Gene Therapy 7: 557-562 (2000).Fujii, K., Yokoyama, N., Kiyono, T., Kuzushima, K., Homma, M., Nishiyama, Y., Fujita, M. and Tsurumi, T.
The Epstein-Barr virus pol catalytic subunit physically interacts with the BBLF4-BSLF1-BBLF2/3 complex.
Journal of Virology 74: 2550-2557 (2000).Goshima, F.,Watanabe, D.,Takakuwa, H.,Wada, K.,Daikoku, T.,Yamada, M. and Nishiyama, Y.
Herpes simplex virus UL17 protein is associated with B capsids and colocalizes with ICP35 and VP5 in infected cells.
Archives of Virology 145: 417-426 (2000).Murata, T., Goshima, F., Daikoku, T., Inagaki, K., Takakuwa, H., Kato, K. and Nishiyama, Y.
Mitochondrial distribution and function in herpes simplex virus -infected cells.
Journal of General Virology 81: 401-406 (2000).【1999年】
Kasuya, H., Nishiyama, Y., Nomoto, S., Hosono, J., Takeda, S. and Nakao, A.
Intraperitoneal delivery of hrR3 and ganciclovir prolongs survival in mice with disseminated pancreatic cancer.
Journal of Surgical Oncology 72: 136-141 (1999).Yokoyama, N., Fujii, K., Hirata, M., Tamai, K., Kiyono, T., Kuzushima, K., Nishiyama, Y., Fujita, M. and Tsurumi, T.
Assembly of the Epstein-Barr virus BBLF4, BSLF1 and BBLF2/3 proteins and their interactive properties.
Journal of General Virology 80: 2879-2887 (1999).Wada, K., Goshima, F., Takakuwa, H., Yamada, H., Daikoku, T. and Nishiyama, Y.
Identification and characterization of the UL14 gene product of herpes simplex virus type 2.
Journal of General Virology 80: 2423-2431 (1999).Zhu, H.-Y., Yamada, H., Jiang, Y.-M., Yamada, M. and Nishiyama, Y.
Intracellular localization of the UL31 protein of herpes simplex virus type 2.
Archives of Virology 144: 1923-1935 (1999).Yamada, H., Jiang, Y.-M., Zhu, H.-Y., Inagaki, -O. K. and Nishiyama, Y.
Nucleolar localization of the UL3 protein of herpes simplex virus type 2.
Journal of General Virology 80: 2157-2164 (1999).Hata, S., Koyama, H., Shiota, H., Adachi, A., Goshima, F. and Nishiyama, Y.
Antiapoptotic activity of herpes simplex virus type 2: the role of US3 protein kinase gene.
Microbes and Infection 1: 601-607 (1999).Iwayama, S., Ohmura, Y., Suzuki, K., Ono, N., Nakazawa, H., Aoki, M., Tanabe, I., Sekiyama, T., Tsuji, T., Okunishi, M., Yamanishi, K. and Nishiyama, Y.
Evalution of anti-herpesvirus activity of (1'S, 2'R)-9-[[1', 2'-bis(hydroxymethyl)cycloprop-1'-yl]methyl]-guanine (A-5021) in mice.
Antiviral Research 42: 139-148 (1999).Watanabe, D., Adachi, A., Tomita, Y., Yamamoto, M., Kobayashi, M. and Nishiyama, Y.
The role of polymorphonuclear leukocyte infiltration in herpes simplex virus infection of murine skin.
Archives of Dermatological Research 291: 28-36 (1999).
Asano, S., Honda, T., Goshima, F., Watanabe, D., Miyake, Y., Sugiura, Y. and Nishiyama, Y. US3 protein kinase of herpes simplex virus type2 plays a role in protecting corneal epithelial cells from apoptosis in infected mice.
Journal of General Virology 80: 51-56 (1999).【1998年】
Daikoku, T., Ikenoya, K., Yamada, H., Goshima, F. and Nishiyama, Y.
Identification and characterization of the herpes simplex virus type 1 UL51 gene product.
Journal of General Virology 79: 3027-3031 (1998).
Koyama, H., Akari, H., Adachi, A., Goshima, F. and Nishiyama, Y.
Induction of apoptosis in HEp-2 cells by infection with herpes simplex virus type 2.
Archives of Virology 143: 2435-2441 (1998).
Jiang, Y.-M., Yamada, H., Goshima, F., Daikoku, T., Oshima, S., Wada, K. and Nishiyama, Y.
Characterization of the herpes simplex virus type 2 (HSV-2) US2 gene product and a US2-deficient HSV-2 mutant.
Journal of General Virology 79: 2777-2784 (1998).
Ono, N., Iwayama, S., Suzuki, K., Sekiyama, T., Nakazawa, H., Tsuji, T., Okunishi, M., Daikoku, T. and Nishiyama, Y.
Mode of action of (1'S,2'R)-9-[[1',2'-bis (hydroxymethyl) cycloprop-1'-yl] methyl] guanine (A-5021) against herpes simplex virus type 1 and type 2 and varicella-zoster virus.
Antimicrobial Agents and Chemotherapy 42: 2095-2102 (1998).
Iwayama, S., Ono, N., Ohmura, Y., Suzuki, K., Aoki, M., Nakazawa, H., Oikawa, M., Kato, T., Okunishi, M., Nishiyama, Y. and Yamanishi, K.
Antiherpesvirus activities of (1'S,2'R)-9-[[1',2'-bis(hydroxymethyl) cycloprop-1'-yl]methyl] guanine (A-5021) in cell culture.
Antimicrobial Agents and Chemotherapy 42:1666-1670 (1998).
Yamada, H., Jiang, Y. -M., Oshima, S., Wada, K., Goshima, F., Daikoku, T. and Nishiyama, Y.
Characterization of the UL4 gene product of herpes simplex virus type 2.
Archives of Virology 143: 1199-1207 (1998).
Yamada, H., Jiang, Y. -M., Oshima, S., Daikoku, T., Yamashita, Y., Tsurumi, T. and Nishiyama, Y.
Characterization of the UL55 gene product of herpes simplex virus type 2.
Journal of General Virology 79: 1985-1995 (1998).
Oshima, S., Daikoku, T., Shibata, S., Yamada, H., Goshima, F. and Nishiyama, Y.
Characterization of the UL16 gene product of herpes simplex virus type 2.
Archives of Virology 143: 863 - 880 (1998).
Tsurumi, T., Kishore, J., Yokoyama, N., Fujita, M., Daikoku, T., Yamada, H., Yamashita, Y. and Nishiyama, Y.
Overexpression, purification and helix-destabilizing properties of Epstein-Barr virus single-stranded DNA-binding protein.
Journal of General Virology 79: 1257-1264 (1998).
Goshima, F., Daikoku, T., Yamada, H., Oshima, S., Tsurumi, T. and Nishiyama, Y.
Subcellular localization of the US3 protein kinase of herpes simplex virus type 2.
Archives of Virology 143: 613-622 (1998).
【1997年】
Wada, K., Mizuno, S., Ohata, H. and Nishiyama, Y.
Immune response to neutralizing epitope on human cytomegalovirus glycoprotein B in Japanese: correlation of serologic response with HLA-type.
Microbiology and Immunology 41: 841 - 845 (1997) .
Yamada, H., Daikoku, T., Yamashita, Y., Jiang, Y.-M., Tsurumi, T. and Nishiyama, Y.
The product of the US10 gene of herpes simplex virus type 1 is a capsid/tegument -associated phosphoprotein which copurifies with the nuclear matrix.
Journal of General Virology 78: 2923 - 2931 (1997).
Daikoku, T., Shibata, S., Goshima, F., Oshima, S., Tsurumi, T., Yamada, H., Yamashita, Y. and Nishiyama, Y.
Purification and characterization of the protein kinase encoded by the UL13 gene of herpes simplex virus type 2.
Virology 235: 82 - 93 (1997).
Tsurumi, T., Yamada, H., Daikoku, T., Yamashita, Y. and Nishiyama, Y.
Strand displacement associated DNA synthesis catalyzed by the Epstein-Barr virus DNA polymerase.
Biochemical and Biophysical Research Communications 238: 33 - 38 (1997).
Ozaki, N., Sugiura, Y., Yamamoto, N., Yokota, S., Wanaka, A. and Nishiyama, Y.
Apoptosis induced in the spinal cord and dorsal root ganglion by infection of herpes simplex virus type 2 in the mouse.
Neuroscience Letters 228: 99 - 102 (1997).【1996年】
Nishiyama, Y. Herpesvirus genes: Molecular basis of viral replication and pathogenicity.
Nagoya Journal of Medical Science 59: 107 - 119 (1996).
Ozaki, N., Sugiura, Y., Yamamoto, M. and Nishiyama, Y.
Induction of Fos protein expression in spinal cord neurons by herpes simplex virus infections in the mouse.
Neuroscience Letters 216: 61 - 64 (1996).
Yamashita, Y., Yamada, M., Daikoku, T., Yamada, H., Tadauchi, A., Tsurumi, T. and Nishiyama, Y.
Calnexin associates with the precursors of glycoprotein B, C, and D of herpes simplex virus type 1.
Virology 225: 216 - 222 (1996).
Tsurumi, T., Kobayashi, A., Tamai, K., Yamada, H., Daikoku, T., Yamashita, Y. and Nishiyama, Y.
Epstein-Barr virus single-stranded DNA-binding protein: Purification, characterization, and action on DNA synthesis by the viral DNA polymerase.
Virology 222: 352 - 364 (1996).
Yamashita, Y., Shimokata, K., Mizuno, T., Daikoku, T., Tsurumi, T. and Nishiyama, Y. Calnexin acts as a molecular chaperone during the folding of glycoprotein B of human cytomegalovirus.
Journal of Virology 70: 2237-2246 (1996).
Yamamoto, M., Kurachi, R., Morishima, T., Kito, J. and Nishiyama, Y.
Immunohistochemical studies on the transneuronal spread of virulent herpes simplex virus type 2 and its US3 protein kinase-deficient mutant after ocular inoculation.
Microbiology and Immunology 40: 289-294 (1996).【1995年】
Jiang, Y.-M., Daikoku, T., Yamamoto, M., Morishima, T. and Nishiyama, Y.
Growth and cytopathogenicity of herpes simplex virus in a macrophage cell line, RAW264: A good indicator of intraperitoneal pathogenicity.
Microbiology and Immunology 39: 905-909 (1995).
Daikoku, T., Yamashita, Y., Tsurumi, T. and Nishiyama, Y.
The US3 protein kinase of HSV type 2 is associated with phosphorylation of the UL12 alkaline nuclease in vitro.
Archives of Virology 140: 1637-1644 (1995).
Nawa, A., Nishiyama, Y., Kobayashi, T., Wakahara, Y., Okamoto, T., Kikkawa, F., Suganuma, N., Goto, S., Kuzuya, K. and Tomoda, Y.
Association of HLA-B1*03 with cervical cancer in Japanese women aged 35 and younger.
Cancer 75: 518-521 (1995).
Kobayashi, T., Yokoyama, I., Nishiyama, Y., Hayashi, S., Uchida, K. and Takagi, H.
Strong enhancement of HLA class I surface expression by incomplete cytomegalovirus particle: Analysis by dual-color flow cytometry using saponin.
Transplantation Proceedings 27: 966-969 (1995).【1994年】
Yamashita,Y., Shimokata,K., Saga,S., Mizuno,S., Tsurumi,T. and Nishiyama,Y.
Rapid degradation of the heavy chain of class I major histocompatibility antigens in the endoplasmic reticulum of human cytomegalovirus-infected cells.
Journal of Virology 68: 7933-7943 (1994).
Daikoku,T., Kurachi,R., Tsurumi,T. and Nishiyama,Y.
Identification of a target protein of US3 protein kinase of herpes simplex virus type 2.
Journal of General Virology 75: 2065-2068 (1994).
Tsurumi,T., Daikoku,T. and Nishiyama,Y.
Further characterization of the interaction between Epstein-Barr virus DNA polymerase catalytic subunit and its accessory subunit with regard to the 3'-to-5' exonucleotic activity and stability of initiation complex at primer termini.
Journal of Virology 68: 3354 - 3363 (1994).