Selected Publications 1997-2003
1. Toyokuni S et al. Quantitative immunohistochemical determination of 8-hydroxy-2'-deoxyguanosine by a monoclonal antibody N45.1: its application to ferric nitrilotriacetate-induced renal carcinogenesis model. Lab Invest 76: 365-374, 1997 (cited more than 200 times; now commercially available).
2. Toyokuni S et al. Induction of a wide range of C2-12 aldehydes and C7-12 acyloins in the kidney of Wistar rats after treatment with a renal carcinogen, ferric nitrilotriacetate. Free Radic Biol Med 22: 1019-1027, 1997.
3. Tanaka T et al. Induction and nuclear translocation of thioredoxin by oxidative damage in the mouse kidney: independence of tubular necrosis and sulfhydryl depletion. Lab Invest 77: 145-155, 1997.
4. Leinonen J et al. New biomarker evidence of oxidative stress in NIDDM patients. FEBS Lett 417: 150-152, 1997.
5. Tanaka T et al. Overexpression of glutathione S-transferase Yp isozyme and concomitant downregulation of Ya isozyme in renal cell carcinoma of rats induced by ferric nitrilotriacetate. Carcinogenesis 19: 897-903, 1998.
6. Toyokuni S et al. Development of high-grade renal cell carcinoma in rats independent of somatic mutations in the Tsc2 and VHL tumor suppressor genes. Jpn J Cancer Res 89: 814-820, 1998.
7. Toyokuni S. Reactive oxygen species-induced molecular damage and its application in pathology. Pathol Int 49: 91-102, 1999 (cited more than 100 times; cited in Robbins Basic Pathology 7th edition, Saunders; the most frequently downloaded article in Pathol Int during 2004).
8. Tanaka T et al. High incidence of allelic loss on chromosome 5 and inactivation of p15 INK4B and p16 INK4A tumor suppressor genes in oxystress-induced renal cell carcinoma of rats. Oncogene 18: 3793-3797, 1999 (origin of the concept of oxygenomics).
9. Toyokuni S et al. Intranuclear distribution of 8-hydroxy-2'-deoxyguanosine: an immunocytochemical study. J Histochem Cytochem 47: 833-835, 1999.
10. Ihara Y et al. Hyperglycemia causes oxidative stress in pancreatic beta-cells of GK rats, a model of type 2 diabetes. Diabetes 48: 927-932, 1999 (demosntration of oxidative stress in type 2 diabetic pathology).
11. Matsui M et al. The role of oxidative DNA damage in human arsenic carcinogenesis: detection of 8-hydroxy-2'-deoxyguanosine in arsenic-related Bowen's disease. J Invest Dermatol 113:26-31, 1999.
12. Kondo S et al. Persistent oxidative stress in human colorectal adenoma, but not in adenoma. Free Radic Biol Med 27: 401-410, 1999.
13. Kondo S et al. Overexpression of the hOGG1 gene and high 8-hydroxy-2' deoxyguanosine (8-OHdG) lyase activity in human colorectal carcinoma: regulation mechanism of the 8-OHdG level in DNA. Clin Cancer Res 6:1394-400, 2000.
14. Tanaka et al. Expression of stress-response and cell proliferation genes in renal cell carcinoma induced by oxidative stress. Am J Pathol 156:2149-2157, 2000.
15. Ihara et al. Antioxidant alpha-tocopherol ameliorates glycemic control of GK rats, a model of type 2 diabetes. FEBS Lett 473:24-6, 2000.
16. Kawashima et al. Cytoprotective effects of nitroglycerin in ischemia-reperfusion-induced lung injury. Am J Respir Crit Care Med 161:935-43, 2000.
17. Ban N et al. Activating transcription factor-2 is a positive regulator in CaM kinase IV-induced human insulin gene expression. Diabetes 49:1142-8, 2000.
18. Mori M et al. Spontaneous loss-of-function mutations of the 8-oxoguanine DNA glycosylase gene in mice and exploration of the possible implication of the gene in senescence. Free Radic Biol Med 30: 1130-1136, 2001.
19. Ichihashi K et al. Endogenous formation of protein adducts with carcinogenic aldehydes. implications for oxidative stress. J Biol Chem 276: 23903-13, 2001.
20. Toyokuni S et al. An electron spin resonance study on alkylperoxyl radical in thin-sliced renal tissues from ferric nitrilotriacetate-treated rats: the effect of a-tocopherol feeding. Free Radic Res 35: 245-255 2001.
21. Hiroyasu M et al. Specific allelic loss of p16INK4A tumor suppressor gene after weeks of iron-mediated oxidative damage during rat renal carcinogenesis. Am J Pathol 160: 419-424, 2002 (fragile sites in the genome against oxidative stress).
22. Kondo S, Toyokuni S, Tsuruyama T, Ozeki M, Tachibana T, Echizenya M, Hiai H, Onodera H, and Imamura M. Peroxynitrite-mediated stress is associated with proliferation of human metastatic colorectal carcinoma in the liver. Cancer Lett 179: 87-93, 2002.
23. Toyokuni S, Itani T, Morimitsu Y, Okada K, Ozeki M, Kondo S, Uchida K, Osawa T, Hiai H, and Tashiro T. Protective effect of colored rice over white rice on Fenton reaction-based renal lipid perixidation in rats. Free Radic Res 36: 583-592, 2002 (colored rice works against oxidative stress at a specific condition).
24. Shimoi K, Kasai H, Yokota N, Toyokuni S, and Kinae N. Comparison between HPLC analysis and a commercially available ELISA assay for the determination of 8-hydroxy-2'-deoxyguanosine in human urine. Cancer Epidem Biomar 11: 767-770, 2002.
25. Kanatsu-Shinohara M, Ogura A, Ikegawa M, Inoue K, Ogonuki N, Tashiro K, Toyokuni S, Honjo T, and Shinohara T. Adenovirus-mediated gene delivery and in vitro microinsemination produce offspring from infertile male mice. Proc Natl Acad Sci USA 99:1383-1388, 2002.
26. Hiroyasu M, Ozeki M, Miyagawa-Hayashino A, Fujiwara Y, Hiai H, and Toyokuni S. Novel surrogate endpoint biomarker to evaluate agents for use in the chemoprevention of reactive oxygen species-associated cancer. Red Report 7: 335-338, 2002.
27. Jikimoto T, Nishikubo Y, Koshiba M, Kanagawa S, Morinobu S, Morinobu A, Saura R, Mizuno K, Kondo S, Toyokuni S, Nakamura H, Yodoi J, and Kumagai S. Thioredoxin as a biomarker for oxidative stress in patients with rheumatoid arthritis.
Mol Immunol. 38:765-772, 2002.28. Miwa S, Toyokuni S, Nishina T, Nomoto T, Nishimura K, and Komeda M. Spaciotemporal alteration of 8-hydroxy-2'-deoxyguanosine levels in cardiomyocytes after myocardial infarction in rats. Free Radic Res 36: 853-858, 2002.
29. Ozeki M, Hoshino S, Hiai H, and Toyokuni S. Isolation and characterization of annexin 2 pseudogene in rattus norvegicus. Gene 289: 185-190, 2002.
30. Nakamura K, Kusano K, Nakamura Y, Kakishita M, Ohta K, Nagase S, Yamamoto M, Miyaji K, Saito H, Morita H, Emori T, Matsubara H, Toyokuni S, and Ohe T. Carvedilol Decreases Elevated Oxidative Stress in Human Failing Myocardium. Circulation 105:2867-2871, 2002.
31. Yoshida N, Murase H, Kunieda T, Toyokuni S, Tanaka T, Terao J, Naito Y, Tanigawa T, and Yoshikawa T. Inhibitory effect of a novel water-soluble vitamin E derivative on atherosclerosis in rabbits. Atherosclerosis 162:111-7, 2002.
32. Ban N, Yamada Y, Someya Y, Miyawaki K, Ihara Y, Hosokawa M, Toyokuni S, Tsuda K, and Seino Y. Hepatocyte Nuclear Factor-1alpha Recruits the Transcriptional Co-Activator p300 on the GLUT2 Gene Promoter. Diabetes 51:1409-1418, 2002.
33. Toyokuni S. Iron and carcinogenesis: From Fenton reaction to target genes. Red Report 7:189-197, 2002 (review).
34. Miyawaki K, Yamada Y, Ban N, Ihara Y, Tsukiyama K, Zhou H, Fujimoto S, Oku A, Tsuda K, Toyokuni S, Hiai H, Mizunoya W, Fushiki T, Holst JJ, Makino M, Tashita A, Kobara Y, Tsubamoto Y, Jinnouchi T, Jomori T, and Seino Y. Inhibition of GIP signal prevents obesity. Nature Medicine 8: 738-742, 2002.
35. Ueno Y, Horio F, Uchida K, Naito M, Nomura H, Kato Y, Tsuda T, Toyokuni S, Osawa T. Increase in oxidative stress in kidneys of diabetic Akita mice. Biosci Biotechnol Biochem 66:869-72, 2002.
36. Sakamaki K, Inoue T, Asano M, Sudo K, Kazama H, Sakagami J, Sakata S, Ozaki M, Nakamura S, Toyokuni S, Osumi N, Iwakura Y, and Yonehara S. Ex vivo whole-embryo culture of caspase-8-deficient embryos normalize their aberrant phenotypes in the developing neural tube and heart. Cell Death Differ 9: 1196-1206, 2002.
37. Kallay E, Bareis P, Bajna E, Kriwanek S, Bonner E, Toyokuni S, and Cross HS. Vitamin D receptor activity and prevention of colonic hyperproliferation and oxidative stress. Food Chem Toxicol 40:1191-1196, 2002
38. Kanatsu-Shinohara M, Ogonuki N, Inoue K, Ogura A, Toyokuni S, Honjo T, and Shinohara T. Allogeneic offspring produced by male germ line stem cell transplantation into infertile mouse testis. Biol Reprod 68: 167-173, 2003.
39. Shinohara T, Inoue K, Ogonuki N, Kanatsu-Shinohara M, Miki H, Nakata K, Kurome M, Nagashima H, Toyokuni S, Kogishi K, Honjo T, and Ogura A. Birth of offspring following transplantation of cryopreserved immature testicular piece and in vitro microinsemination. Hum Reprod 17: 3039-3045, 2002.
40. Omasa M, Fukuse T, Toyokuni S, Mizutani Y, Yoshida H, Ikeyama K, Hasagawa S, and Wada H. Glycine ameliorates lung reperfusion injury after cold preservation in an ex vivo rat lung model. Transplantation 75:591-598, 2003.
41. Toyokuni S, Kawaguchi W, Akatsuka S, Hiroysu M, and Hiai H. Intermittent microwave irradiation facilitates antigen-antibody reaction in Western blot analysis. Pathology Int 53:259-261, 2003 (fastest Western blot method thus far!).
42. Hashimoto M, Shibata T, Wasada H, Toyokuni S, and Uchida K. Structural basis of protein-bound endogenous aldehydes: Chemical and immunochemical characterizations of configurational isomers of a 4-hydroxy-2-nonenal-histidine adduct. J Biol Chem 278: 5044-5051, 2003.
43. Kuroda K, Han H, Tani S, Tanigaki K, Tun T, Furukawa T, Taniguchi Y, Kurooka H, Hamada Y, Toyokuni S, and Honjo T. Increased marginal zone B cells in deficiency of MINT, a negative regulator of Notch/RBP-J signaling. Immunity 18: 301-312 2003.
44. Ishikawa T, Yoshida N, Tokuda H, Ichiishi E, Kuchide M, Kokura S, Naito Y, Toyokuni S, Nishino H, and Yoshikawa T. Tumor initiating activity of Helicobacter pylori water extract on mouse skin carcinogenesis. Cancer Lett. 191:41-47, 2003.
45. Aoi W, Naito Y, Sakuma K, Kuchide M, Tokuda H, Maoka T, Toyokuni S, Oka S, Yasuhara M, and Yoshikawa T. Astaxanthin limits exercise-induced skeletal and cardiac muscle damage in mice. Antioxid Redox Signal. 5: 139-144, 2003.