Selected Classic Works
Copper
1. Toyokuni, S et al. Cirrhosis of the liver induced by cupric nitrilotriacetate in Wistar rats: an experimental model of copper toxicosis. Am J Pathol 134: 1263 1274, 1989.
2. Toyokuni, S et al. Induction of renal cell carcinoma in male Wistar rats treated with cupric nitrilotriacetate. Lab Invest 75: 239-248, 1996.
3. Toyokuni, S and Sagripanti, J-L. Association between 8-hydroxy-2'-deoxyguanosine formation and DNA strand breaks mediated by copper and iron. Free Radic Biol Med 20: 859-864, 1996.
Ferric Nitrilotriacetate (Oxidative DNA damage and carcinogenesis)
1. Toyokuni, S et al. Combined histochemical and biochemical analysis of sex hormone-dependence of ferric nitrilotriacetate-induced renal lipid peroxidation in ddY mice. Cancer Res 50: 5574-5580, 1990.
2. Toyokuni, S and Sagripanti, J-L. DNA single and double strand breaks produced by ferric nitrilotriacetate in relation to renal tubular carcinogenesis. Carcinogenesis 14: 223-227, 1993.
3. Toyokuni, S and Sagripanti, J-L. Induction of oxidative single and double strand breaks in DNA by ferric citrate. Free Radic Biol Med 15: 117-123, 1993.
4. Toyokuni, S et al. DNA base modifications in renal chromatin of Wistar rats treated with a renal carcinogen, ferric nitrilotriacetate. Int J Cancer 57: 123-128, 1994.
5. Toyokuni, S et al. Treatment of Wistar rats with a renal carcinogen, ferric nitrilotriacetate, causes DNA-protein cross-linking between thymine and tyrosine in their renal chromatin. Int J Cancer 62: 309-313, 1995.
6. Nishiyama, Y et al. Low incidence of point mutations in H-, K- and N-ras oncogenes and p53 tumor suppressor gene in renal cell carcinoma and peritoneal mesothelioma of Wistar rats induced by ferric nitrilotriacetate. Jpn J Cancer Res 86: 1150-1158, 1995.
7. Toyokuni, S. Iron-induced carcinogenesis: the role of redox regulation. Free Radic Biol Med 20: 553-566, 1996 (review article).
4-Hydroxy-2-nonenal
1. Toyokuni, S et al. Formation of 4-hydroxy-2-nonenal-modified proteins in the renal proximal tubules of rats treated with a renal carcinogen, ferric nitrilotriacetate. Proc Natl Acad Sci USA 91: 2616-2620, 1994 (cited more than 200 times).
2. Toyokuni, S et al. The monoclonal antibody specific for the 4-hydroxy-2-nonenal histidine adduct. FEBS Lett 359: 189-191, 1995 (Production of HNEJ-2; now commercially available).
3. Uchida, K et al. A renal carcinogen ferric nitrilotriacetate mediates a temporary accumulation of aldehyde-modified proteins within cytosolic compartment of rat kidney. Arch Biochem Biophys 317: 405-411, 1995.
Oxidative Stress in Tumor Biology
1. Okamoto, K et al. Formation of 8-hydroxy-2'-deoxyguanosine and 4-hydroxy-2 nonenal-modified proteins in human renal cell carcinoma. Int J Cancer 58: 825 829, 1994.
2. Toyokuni, S et al. Hypothesis: Persistent oxidative stress in cancer. FEBS Lett 358: 1-3, 1995 (review article; cited more than 200 times).
3. Okamoto, K et al. Overexpression of human mut T homologue gene messenger RNA in renal cell carcinoma: evidence for persistent oxidative stress in cancer. Int J Cancer 65: 437-441, 1996.
UV
1. Hattori-Nakakuki Y, et al. Formation of 8-hydroxy-2'-deoxyguanosine in epidermis of hairless mice exposed to near-UV. Biochem Biophys Res Commun 201: 1132-1139, 1994.
- 2. Hattori, Y et al. 8-Hydroxy-2'-deoxyguanosine is increased in epidermal cells of hairless mice after chronic UVB exposure. J Invest Dermatol 107: 733-737, 1996.