Research Groups

Research Groups

A01: Brain protein aging and neural circuit breakdown

• A01-1: Visualization of brain protein aging and clarification of the mechanisms of neural circuit breakdown
• A01-2: Elucidation of mechanism for neural network disruption by protein-specific PET imaging

A02: Molecular bases of brain protein aging

• A02-1: Mechanism of tau protein aging and toxicity
• A02-2: Molecular bases of pathogenic proteins and mechanisms of the propagation
• A02-3: Protein aging from perturbation of robustness of nucleic acid metabolism and its elimination mechanism.

A03: Therapeutic development for brain protein aging

• A03-1: Establishment of brain protein aging models; human iPS cell model and non-human primate model
• A03-2: Development of imaging-based diagnostic procedures for brain protein aging

Director

Gen Sobue Research Division of Dementia and Neurodegenerative Disease,Nagoya University Graduate School of Medicine Brain & Mind Research Center, Nagoya University

Group Leaders

	Kazuhiko Yanai Professor, Graduate School of Medicine, Division of Pharmacology, Tohoku University		Akihiko Takashima Professor, Laboratory for Alzheimer’s disease　Department of Life Science　Faculty of Science　Gakushuin University
	Masato Hasegawa Head, Department of Dementia and Higher Brain Function, Tokyo Metropolitan Institute of Medical Science		Osamu Onodera Professor, Department of Molecular Neuroscience, Brain Research Institute, Niigata University
	Hideyuki Okano Professor, Graduate School of Medicine Department of Physiology, Keio University		Naruhiko Sahara Team Researcher, Molecular Neuroimaging Program, Neuromolecular Dynamics Team, Molecular Imaging Center

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Group Members

A01-1: Visualization of brain protein aging and clarification of the mechanisms of neural circuit breakdown

	Gen Sobue Research Division of Dementia and Neurodegenerative Disease,Nagoya University Graduate School of Medicine Brain & Mind Research Center, Nagoya University		Kengo Itoh Chief, National Center for Geriatrics and Gerontology
	Hirohisa Watanabe Designated Professor, Brain and Mind Research Center Division, Nagoya University		Tetsuya Suhara Chief, Department of Molecular Neuroimaging, Molecular Imaging Center
	Masahisa Katsuno Professor, Nagoya University		Naoki Atsuta Lecturer, Nagoya University
	Hiroki Tanabe Professor, Nagoya University		Shigeomi Shimizu Professor, Tokyo Medical and Dental University
	Hiroko Bannai Affiliation / Position, JST PRESTO/RIKEN

A01-2: Elucidation of mechanism for neural network disruption by protein-specific PET imaging

	Kazuhiko Yanai Professor, Tohoku University		Nobuyuki Okamura Professor, Tohoku Medical and Pharmaceutical University
	Shozo Furumoto Professor, Cyclotron and Radioisotope Center, Tohoku University

A02-1: Molecular mechanism of brain protein aging

	Akihiko Takashima Professor, Gakushuin University		Shinichi Hisanaga Professor, Tokyo Metropolitan University
	Tomohiro Miyasaka Associate Professor, Doshisha University		Masaya Ikegawa Professor, Doshisha University
	Shinsuke Ishigaki Designated Assistant Professor, Nagoya University		Akio Sumioka Assistant Professor,Gakushuin University
	Hiroaki Misono Professor, Doshisha University		Akiko Taguchi Chief, National Center for Geriatrics and Gerontology

A02-2: Molecular bases of pathogenic proteins and mechanisms of the propagation

Masato Hasegawa Head, Department of Dementia and Higher Brain Function, Tokyo Metropolitan Institute of Medical Science

Tetsuyuki Kitamoto Professor, Tohoku University

A02-3: Protein aging from perturbation of robustness of nucleic acid metabolism and its elimination mechanism.

Osamu Onodera Professor, Niigata University

Akiyoshi Kakita Professor, Niigata University

A03-1: Establishment of brain protein aging models; human iPS cell model and non-human primate model

Hideyuki Okano Professor, Keio University

Seiji Shiozawa Lecturer, Keio University

A03-2: Development of imaging-based diagnostic procedures for brain protein aging

	Sahara Naruhiko Team Researcher, National Institute of Radiological Sciences		Yoshiki Yamaguchi Team Leader, RIKEN-Max Planck Joint Research Center for Systems Chemical Biology, RIKEN
	Makoto Higuchi Team Leader, National Institute of Radiological Sciences		Takafumi Minamimoto Team Leader, National Institute of Radiological Sciences
	Ichio Aoki Team Leader, National Institute of Radiological Sciences		Gen Matsumoto Lecture, Nagasaki University School of Medicine

External Evaluation Committee