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Biomedical RegulationAnesthesiology

Introduction

Professor Kimitoshi Nishiwaki, MD, PHD who became professor from 2008, took up the post. In recent years, a full renovation of the laboratory has been implemented. We are confident that we will achieve further results in the future. The researchs covers a wide range of fields, from basic research conducted by science and engineering instructors to voluntary clinical research conducted by instructors focusing on hospital clinics to clinical trials. Not only in the course itself, but also in the field of necessary experiments and analysis, we cooperate with other department or division in a wide range of fields, and we are making efforts to respond to many research needs.

Research Projects

New projects from 2016

  1. Takahiro Andoh. Detection of the nerve block catheter using ultrasound sonography (Sonoe Shinaya, Yu Fujii, Atsushi Mori)
  2. Akihiro Hirai. Combined cancer therapy with volatile anesthetics and anti-cancer drugs. (Yuko Konishi, Kimitoshi Nishiwaki)
  3. Takehito Satoh. The observation of microglia cell in spinal dorsal horn using neuropathic and allodia modeled mice. (Hiroshi Kimura, Hiroyuki Konishi, Department of Functional Histology)
  4. Takehito Satoh. The observation of macrophage in dura mater using migraine modeled mice.
  5. Yu Fujii. The difference of analgesic effect between bolus administration and continuous administration of local anesthetics in patients undergone thoracoscopic lower lobectomy using ultrasound-guided para-vertebral aploach. (Sonoe Shinya, Yasuyuki Shibata)
  6. Shigeki Miyata. The best practice for Massive bleeding. (Kimitoshi Nishiwaki, Akihiko Usui, Tadashi Matsushita, with 4 Institute of Medical School and 4 other institutes)
  7. Kimitoshi Nishiwaki. The development of neuromuscular monitoring system using detecting a change in magnetic signals. (Shogo Suzuki, Takahiro Andoh, Masao Kondoh, Shinsuke Nakayama (Department of Cellular Physiology), Goh Uchiyama (Department of Intelligence Technology, System), Hideki Miyazaki (Fuji Denolo).
  8. Shogo Suzuki. The reliability concerning the values of bedside point of care coagulation monitoring.
  9. Shogo Suzuki. The possible mechanism of lidocaine-induced suppression of angiogenesis using normal human umbilical vein endothelial cells. (Atsushi Mori)
  10. Tadashi Aoyama, Kimitoshi Nishiwaki. The effectiveness of the monitoring of motor evoked potential and spinal drainage for the patient undergone thoracic and thoraco-abdominal aorta surgery. (National Cerebral and Cardiovascular Center and other 15 institutes)
  11. Tadashi Aoyama. Post-operative cognitive dysfunction and delirium caused by the mitochondrial impairments. (Takashi Ichikawa, Atsushi Mori)
  12. Takahiro Andoh. Safety of Yabashi-lime, a newly developed carbon-dioxide amsorber. (Takehiro Satoh, AtsushiMori)
  13. Kanako Ozeki. The effect of anesthetics on the intracellular responses against stress. (Department of Cancer Biology)
  14. Akiko Akane. The comparison of the analgesic protocols for lower abdominal open gynecologic surgery - the different concentration and dose of ropivacaine for peripheral nerve blocks with patient controlled intravenous analgesia. (Yasuyuki Shibata, Kimitoshi Nisiwaki)
  15. Yu Fujii. The relationships between the approaches of para-vertebral nerve block with ultrasound guidance and the spreads of local anesthetics with placed catheter. Yasuyuki Shibata, Kimitoshi Nishiwaki)
  16. Yu Fujii. The effectiveness of the para-vertebral block on the sternotomy of cardiovascular urgery. (Yasuyuki Shibata, Kimitoshi Nishiwaki, Hospital Pharmacy)
  17. Yu Fujii. The effectiveness of infrathoracic block using ultrasound guidance for patients undergone mastectomy. (Department of 2nd Operation Room, Yasuyuki Shibata, Kimitoshi Nishiwaki)
  18. Yuko Konishi. Volatile anesthetics and reversible histone de-methylation. (Akihiro Hirai, Shoko Mizuno, Kimitoshi Nishiwaki)
  19. Motoshi Kainuma. Ethicus II (The international observational study on end-of-life care in the ICU)(Takashi Ichikawa)
  20. Kazumi Kubodera. The comparison between PECS II block and serratus plane block - retrospective study. (Department of 2nd Operation Room, Yasuyuki Shibata, Kimitoshi Nishiwaki)
  21. Yushi Adachi. The development of new pharmacodynamics model using drugs interaction and multi matrix analysis.
  22. Yushi Adachi. The changes in peripheral arterial blood flow after the placement of radial artery catheter.

Faculty Members

FacultyPositionDepartment
Kimitoshi Nishiwaki Professor, Director Department of Anesthesiology
Yasuyuki Shibata Clinical Associate Professor Department of Anesthesiology
Takahiro Tamura Senior assistant Professor/Lecturer Department of Anesthesiology
Kanako Ozeki Clinical Senior assistant Professor/Lecturer Department of Anesthesiology
Tasuku Fujii Clinical Senior assistant Professor/Lecturer Department of Anesthesiology
Yoko Arakawa Assistant Professor Department of Anesthesiology
Shogo Suzuki Assistant Professor Department of Anesthesiology
Ichiko Asano Assistant Professor Department of Anesthesiology
Akiko Sekiguchi Assistant Clinical Professor Department of Anesthesiology
Takahiro Ando Assistant Professor Department of Anesthesiology
Nozomi Nakamura Assistant Professor Department of Anesthesiology
Sonoe Shinya Assistant Clinical Professor Department of Anesthesiology
Akiko Akane Assistant Clinical Professor Department of Anesthesiology
Takahiro Hirai Assistant Clinical Professor Department of Anesthesiology
Tomoaki Kinukawa Assistant Clinical Professor Department of Anesthesiology
Takehito Sato Assistant Clinical Professor Department of Anesthesiology
Tomomi Komaba Assistant Clinical Professor Department of Anesthesiology
Maho Jinno Assistant Clinical Professor Department of Anesthesiology
Nanako Taniguchi Assistant Clinical Professor Department of Anesthesiology
Yutaro Yokoyama Assistant Clinical Professor Department of Anesthesiology
Sho Maeda Assistant Clinical Professor Department of Anesthesiology
Yasuhiro Amano Assistant Clinical Professor, Graduate Student Department of Anesthesiology
Kei Kita Assistant Clinical Professor Department of Anesthesiology
Masashi Takakura Assistant Clinical Professor Department of Anesthesiology
Tomoko Misawa Assistant Clinical Professor, Graduate Student Department of Anesthesiology
Akihiro Yamada Assistant Clinical Professor Department of Anesthesiology
Shino Kawazoe Assistant Clinical Professor Department of Anesthesiology
Ayuki Suzuki Assistant Clinical Professor Department of Anesthesiology
Tomoya Taniguchi Assistant Clinical Professor, Graduate Student Department of Anesthesiology
Mayumi Yamamoto Assistant Clinical Professor Department of Anesthesiology
Yohei Aoki Assistant Clinical Professor Department of Anesthesiology
Kaori Kawabe Assistant Clinical Professor Department of Anesthesiology
Yui Somura Assistant Clinical Professor Department of Anesthesiology
Masayuki Nakamoto Assistant Clinical Professor Department of Anesthesiology
Mayuko Hirao Assistant Clinical Professor Department of Anesthesiology
Akari Matsuura Assistant Clinical Professor Department of Anesthesiology
Keiichiro Inahata Assistant Clinical Professor Department of Anesthesiology
Atsushi Mori Lecturer Donated Funded Laboratory
Yuko Konishi Assistant Professor Donated Funded Laboratory
Takako Ouchiyama Secretary
Aiko Ido Secretary
Jyunko Kubo Secretary

Bibliography

  • 2022
    1. Tamura T, Mori A, Nishiwaki K. The equilibrated blood sevoflurane concentrations show a rapid decrease after switching from ventilation for the human lung to cardiopulmonary bypass. Nagoya J Med Sci. 2021, 83; in press.
  • 2021
    1. Tamura T, Kobayashi E, Kawaguchi M, Matsuoka Y, Fujii A, Ando M, Kubo Y, Imaizumi T, Miyagawa Y, Inagaki T, and Nishiwaki K. Comparison between the effects of normal saline with and without heparin for the prevention and management of arterial catheter occlusion: a triple-blinded randomized trial Journal of Anesthesia. J Anesth. 2021, in press.
    2. Tamura T, Sakai T, Henker RA, O'Donnell JM. Certified Registered Nurse Anesthetist and Anesthesiologist Assistant Education Programs in the United States. Nagoya J Med Sci. 2021, 83; in press.
    3. Tamura T, Mori A, Nishiwaki K. Reply to the Letter. J Anesth. 2021, in press.
    4. Tamura T. Additional Discussion from Anesthesiologists. Ann Thorac Surg. 2021, in press.
    5. Sato T, Konishi H, Tamada H, Nishiwaki K, Kiyama H. Morphology, localization, and postnatal development of dural macrophages. Cell Tissue Res. 2021(in press)
  • 2020
    1. Tamura T, Mori A, Ishii A, Ando M, Kubo Y, Nishiwaki K. Desflurane and Sevoflurane Concentrations in Blood Passing Through the Oxygenator During Cardiopulmonary Bypass: A Randomized Prospective Pilot Study. J Anesth. 2020, in press.
    2. Tamura T, Waters JH, Nishiwaki K. Heparin concentration in cell salvage during heparinization: a pilot study. Nagoya J Med Sci, 2020, 82; in press.
    3. Tamura T, Imaizumi T, Kubo Y, Waters JH, Nishiwaki K. Prompt Prediction of Fibrinogen Concentration during Cardiopulmonary Bypass: A Pilot Study. Nagoya J Med Sci, 2020, 82; in press.
    4. Tamura T, Yokota S, Ito T, Ando M, Kubo Y, Waters JH, Nishiwaki K. Coagulation ability when separating from cardiopulmonary bypass with and without fresh frozen plasma: a pilot study. Gen Thorac Cardiovasc Surg. 2020, in press.
    5. Kubodera K, Fujii T, Akane A, Aoki W, Sekiguchi A, Iwata K, Ban M, Ando R, Nakamura N, Shibata Y, Nishiwaki K. Efficacy of pectoral nerve block type-2 (Pecs II block) versus serratus plane block for postoperative analgesia in breast cancer surgery: a retrospective study. Nagoya J Med Sci. 2020;82(1):93-99.
    6. Fujii T, Shibata Y, Ban Y, Shitaokoshi A, Takahashi K, Matsui S, Nishiwaki K. A single paravertebral injection via a needle vs. a catheter for the spreading to multiple intercostal levels: a randomized controlled trial. J Anesth. 2020 Feb;34(1):72-78.
    7. Fujii T, Yoshitani K, Kanemaru E, Nakai M, Nishimura K, Ohnishi Y, Nishiwaki K. Sizing of mitral annuloplasty rings using real-time three-dimensional transesophageal echocardiography and the difference between patients with and without recurrent mitral regurgitation: retrospective cohort study. J Echocardiogr. 2020 Mar 6.
    8. Fujii T, Shibata Y, Shinya S, Nishiwaki K. Transverse vs. parasagittal in-plane approaches in ultrasound-guided paravertebral block using a microconvex probe: A randomised controlled trial. Eur J Anaesthesiol. 2020 May 7.
    9. Suzuki S, Mori A, Fukui A, Ema Y, Nishiwaki K. Lidocaine inhibits vascular endothelial growth factor-A-induced angiogenesis. J Anesth. in press.
  • 2019
    1. Tamura T, Kaneko K, Yokota S, Kitao T, Ando M, Kubo Y, Nishiwaki K. Comparison between rectus sheath block with 0.25% ropivacaine and local anesthetic infiltration with 0.5% ropivacaine for laparoscopic inguinal hernia repair in children. Nagoya J Med Sci,2019, 81(3),in press.
    2. SatoT, Nishiwaki K. Retrospective investigation about anesthetic management of biliary atresia in children: laparoscopic versus conventional Kasai portoenterostomy. JA Clinical Reports, 2019, 5:7.
    3. TamuraT, Ito T, Yokota S, Ito S, Kubo Y, Ando M, Nishiwaki K. Incidence of reexpansion pulmonary edema in minimally invasive cardiac surgery. Nagoya J Med Sci,2019, in press.
    4. Tamura T. Predicting results of fibrinogen and platelet levels by TEG6s during cardio-pulmonary bypass: a pilot study. J Clin Anesth, 2019 May 9;58:59-60.
    5. Tamura T, Mori A, Nishiwaki K. A drainage system to decrease volatile anesthetic leakage for the several types of oxygenators during cardiopulmonary bypass. J Cardiothorac Vasc Anesth, 2019 May 21. pii: S1053-0770(19)30484-7.
    6. Tamura T, Yokota S, Ando M, Kubo Y, Nishiwaki K. A triple-blinded randomized trial comparing spinal morphine with posterior quadratus lumborum block after cesarean section. Int J Obstet Anesth, 2019, in press.
    7. Tamura T, Measuring suction pressure via a scavenging system. J Anesth, 2019, in press.
    8. Kinukawa T, Takeuchi N, Sugiyama S, Nishihara M, Nishiwaki K, Inui K. Properties of echoic memory revealed by auditory-evoked magnetic fields. Sci Rep. 2019 Aug 22;9(1):12260. Fujii T, Shibata Y, Akane A, Aoki W, Sekiguchi A, Takahashi K, Matsui S, Nishiwaki K. A randomised controlled trial of pectoral nerve-2 (PECS 2) block vs. serratus plane block for chronic pain after mastectomy. Anaesthesia. 2019 Sep 19. in press
    9. Hiral T, Konishi Y, Mizuno S, Rui Z, Sun Y, Nishiwaki K. Differential effects of sevoflurane on the growth and apoptosis of human cancer cell lines. 2019 Des 3. in press.
    10. Fujii T, Shibata Y, Ban Y, Shitaokoshi A, Takahashi K, Matsui S, Nishiwaki K. A single paravertebral injection via a needle vs. a catheter for the spreading to multiple intercostal levels: a randomized controlled trial. 2019 Des 4. in press.
  • 2018
    1. 山田 章宏, 柴田 紘葉, 前田 翔, 竹田 道宏, 竹市 広, 足立 裕史. 高流量経鼻カニューレ酸素投与により重度の呑気症をきたした乳児の1症例; 臨床麻酔 42巻3号 Page511-513(2018.03)
    2. Tamura T, Kitamura K, Yokota S, Ito S, Shibata Y, Nishiwaki K. Spread of quadratus lumborum block to the paravertebral space via intramuscular injection: A volunteer study. Reg Anesth Pain Med. 2018 May;43(4):372-377.
    3. 竹田 道宏, 太田 優也, 前田 翔, 竹市 広, 足立 裕史, 西脇 公俊. 体外補助循環下に一期的全肺洗浄を施行した小児症例. 臨床麻酔;42巻1号 Page91-93(2018.01)
    4. 山田 章宏, 増子 雄二, 柴田 紘葉, 前田 翔, 竹田 道宏, 足立 裕史. 抜管時に経鼻胃管症候群を疑う咽頭粘膜からの出血を生じた1症例. 臨床麻酔 ;42巻2号 Page215-216(2018.02)
    5. Tamura T,Yokota S. Mitral Valve Repair in Infective Endocarditis During Pregnancy. Ann Card Anaesth. 2018 Apr-Jun;21(2):189-191.
    6. Tamura T, Kitamura K, Yokota S, Ito S, Shibata Y, Adachi YU, Nishiwaki K. Reply to Drs. Boghdadly and Elsharkawy. Reg Anesth Pain Med. 2018 Jul;43(5):558-559.
    7. Yasuhide Mitsumoto, Atsushi Mori. Acute Restraint Stress Augments 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine Neurotoxicity via Increased Toxin Uptake into the Brain in C57BL/6 Mice. Neurosci Bull. 2018 Jul 9. [Epub ahead of print]
    8. Kanako Ozeki, Mai Sugiyama, Khondker Ayesha Akter, Kimitoshi Nishiwaki, Eri Asano‑Inami, Takeshi Senga. FAM98A is localized to stress granules and associates with multiple stress granule-localized proteins. Mol Cell Biochem. 2018 Jul 10. [Epub ahead of print]
    9. Tamura T. Ultrasonographic Images of Brachiocephalic Artery in front of Trachea. Asian J Anesthesiol. 2018 [in Press]
    10. Yasuhide Mitsumoto, Atsushi Mori. Acute Restraint Stress Augments 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine Neurotoxicity via Increased Toxin Uptake into the Brain in C57BL/6 Mice. Neurosci Bull. 2018 Jul 9. [Epub ahead of print]
    11. Suzuki S, Tamura T, Hasegawa K, Maeda S, Mori R, Kainuma M, Adachi Y, Nishiwaki K. Fibrinogen levels measured by the dry hematology method are lower than those measured by the Clauss method under a high concentration of heparin. Nagoya J Med Sci,2018, in Press.
    12. Tamura T, Yokota S, Ito S, Shibata Y, Nishiwaki K. Local anesthetic spread into the paravertebral space with two types of quadratus lumborum blocks: A crossover volunteer study. J Anesth, 2018, in press.
  • 2017
    1. Tamura T, Mori S, Mori A, Ando M, Yokota S, Shibata Y, Nishiwaki K. A randomized controlled trial comparing paravertebral block via the surgical field with thoracic epidural block using ropivacaine for post-thoracotomy pain relief. J Anesth. 2017 Apr;31(2):263-270. doi: 10.1007/s00540-017-2307-5. Epub 2017 Jan 23.
    2. Tamura T. Transesophageal Echocardiograms of a Left Atrial Rhabdomyosarcoma. Ann Thorac Surg. 2017 Jun;103(6):e555. doi: 10.1016/j.athoracsur.2017.01.035.
    3. 水野 祥子, 貝沼 関志, 西脇 公俊HIT(heparin-induced thrombocytopenia)-associated consumptive coagulopathyが疑われた症例. 日本集中治療医学会雑誌;24巻1号 Page22-25(2017.01)
    4. Sun Z, Satomoto M, Adachi YU, Makita K. Apocynin preserves glutamatergic neurons in the basolateral amygdala in mice with neonatal sevoflurane exposure. Korean J Anesthesiol. 2017 Jun;70(3):335-340. doi: 10.4097/kjae.2017.70.3.335. Epub 2017 Apr 21.
    5. Satomoto M, Adachi YU, Makita K. A low dose of droperidol decreases the desflurane concentration needed during breast cancer surgery: a randomized double-blinded study. Korean J Anesthesiol. 2017 Feb;70(1):27-32. doi: 10.4097/kjae.2017.70.1.27. Epub 2016 Oct 25.
    6. 藤井 祐, 鈴木 克尚, 柴田 康之, 西脇 公俊. 長期間遺残していた硬膜外カテーテルによる急性硬膜内髄外血腫の経験. 麻酔 66巻1号 Page65-69(2017.01)
    7. 里元麻衣子, 山本雄大, 神山圭, 槇田浩史. 食道がん内視鏡的粘膜下層剥離術(ESD)の術中・術後合併症の検討(続報) 麻酔 in press
    8. Adachi YU, Satomoto M, Nishiwaki K. Rapid Fluid Infusion and Depth of Anesthesia. Anesthesiology. 2017;126:985-986.
    9. 多田真弓, 里元麻衣子, 足立裕史, 西脇公俊. 心不全との鑑別に苦慮した肝肺症候群の1症例. 臨床麻酔 2017; 41: 531-3.
    10. 森 玲央那, 鈴木 章悟, 西脇 公俊. 食道がんに対する腹臥位胸腔鏡下食道亜全摘と開胸手術の周術期予後の比較 後ろ向き観察研究. 麻酔 66巻3号 Page287-290(2017.03)
    11. Ando T, Mori A, Ito R, Nishiwaki K. Important role of calcium chloride in preventing carbon monoxide generation during desflurane degradation with alkali hydroxide-free carbon dioxide absorbents. J Anesth. 2017 Aug 22. doi: 10.1007/s00540-017-2397-0.
    12. 駒場 智美, 長谷川 和子, 新屋 苑恵, 佐藤 威仁, 足立 裕史, 西脇 公俊. 生後7ヵ月で肝移植を実施したアラジール症候群の1例. 臨床麻酔;41巻6号 Page913-914(2017.06)
    13. 柴田 紘葉, 外山 裕貴, 新屋 苑恵, 平井 昂宏, 足立 裕史, 西脇 公俊. McGRATH喉頭鏡を用いても挿管困難であった喉頭蓋嚢胞合併症例. 臨床麻酔;41巻8号 Page1151-1153(2017.08)
    14. 藤井 祐, 青山 正, 石田 祐基, 新屋 苑恵, 貝沼 関志, 西脇 公俊. 僧帽弁形成術後の僧帽弁前尖収縮期前方運動に対してシベンゾリン静脈内投与が有効であった一例. Cardiovascular Anesthesia;21巻1号 Page69-74(2017.08)
    15. 林 智子, 井上 茂, 松本 真理子, 長谷川 和子, 足立 裕史, 西脇 公俊.気道の開存性評価に3D-CTが有用と考えられた1例.臨床麻酔;41巻10号 Page1429-1431(2017.10)
    16. 藤井 祐(名古屋大学医学部附属病院 麻酔科), 石田 祐基, 西脇 公俊. 胸部大血管手術のフィブリノゲン製剤使用の現状 低体温療法による違い. 麻酔 ;66巻10号 Page1043-1050(2017.10)
    17. 青木 和香奈, 浅野 市子, 田原春 早織, 里元 麻衣子, 足立 裕史, 西脇 公俊. 体位性の喘鳴を生じた正中頸嚢胞の1症例. 臨床麻酔;41巻11号 Page1539-1541(2017.11)
    18. 大河 里沙, 関口 明子, 田原春 早織, 里元 麻衣子, 足立 裕史, 西脇 公俊. 麻酔終了時にNSAIDs不耐症を生じたと考えられた1症例. 臨床麻酔41巻12号 Page1675-1676(2017.12)
  • 2016
    1. Hayashi H, Sato W, Kosugi T, Nishimura K, Sugiyama D, Asano N, Ikematsu S, Komori K, Nishiwaki K, Kadomatsu K, Matsuo S, Maruyama S, Yuzawa Y. Efficacy of urinary midkine as a biomarker in patients with acute kidney injury. Clin Exp Nephrol. 2016 Aug 16. [Epub ahead of print]
    2. Fujii T, Shibata Y, Nishiwaki K. Observation of ultrasound-guided thoracic paravertebral block using thoracoscopy. Acta Anaesthesiol Taiwan. 2016 Jun 24. pii: S1875-4597(16)30056-X. doi: 10.1016/j.aat.2016.05.004. [Epub ahead of print] No abstract available.
    3. Tsuzuki Y, Yamashita Y, Hattori Y, Hua Li G, Akatsuka S, Kotani T, Kikkawa F, Naiki-Ito A, Takahashi S, Nishiwaki K, Toyokuni S. Pain-reducing anesthesia prevents oxidative stress in human term placenta. J Clin Biochem Nutr. 2016 Mar;58(2):156-60. doi: 10.3164/jcbn.15-138. Epub 2016 Feb 17.
    4. Obata Y, Adachi YU, Suzuki K, Itagaki T, Kato H, Satomoto M, Nakajima Y. The Influence of Differences in Solvents and Concentration on the Efficacy of Propofol at Induction of Anesthesia. Anesthesiol Res Pract. 2016;2016:9178523. doi: 10.1155/2016/9178523. Epub 2016 Jan 21.
  • 2015
    1. Ishikawa Y, Imagama S, Ito Z, Ando K, Gotoh M, Nishiwaki K, Nagao Y, Ishiguro N. Delayed Onset of Subdural Hematoma following Epidural Catheter Breakage. Global Spine J. 2016 Feb;6(1):e1-6. doi: 10.1055/s-0035-1549030. Epub 2015 Mar 26.
    2. Ohmori T, Shiota N, Haramo A, Masuda T, Maruyama F, Wakabayashi K, Adachi YU, Nakazawa K. Post-operative cardiac arrest induced by co-administration of amiodarone and dexmedetomidine: a case report. J Intensive Care. 2015 Oct 21;3:43. doi: 10.1186/s40560-015-0109-0. eCollection 2015.
    3. Adachi YU, Numaguchi A. Is it possible to identify by ultrasonography at a glance? A leaflet of valve or a flap of dissection. J Clin Anesth. 2015 Aug;27(5):440-1. doi: 10.1016/j.jclinane.2015.03.007. Epub 2015 Apr 14. No abstract available.
  • 2014
    1. Numaguchi A, Adachi YU, Aoki Y, Ishii Y, Suzuki K, Obata Y, Sato S, Nishiwaki K, Matsuda N. Radial artery cannulation decreases the distal arterial blood flow measured by power Doppler ultrasound. J Clin Monit Comput. 2015 Oct;29(5):653-7. doi: 10.1007/s10877-014-9648-5. Epub 2014 Dec 16.
    2. Tochikubo J, Adachi YU, Ejima T, Numaguchi A, Matsuda N, Sato S, Shiiya N. Landiolol reduces hemodynamic responses to bronchoscopy-assisted suctioning in intubated ICU patients. J Intensive Care. 2014 Jan 23;2(1):6. doi: 10.1186/2052-0492-2-6. eCollection 2014.
    3. Suzuki K, Numaguchi A, Adachi YU, Obata Y, Hatano T, Ejima T, Sato S, Matsuda N. Continuous administration of landiolol reduced QT dispersion in postoperative patients. J Clin Anesth. 2014 Sep;26(6):438-42. doi: 10.1016/j.jclinane.2014.01.017. Epub 2014 Sep 6.
    4. Adachi YU, Numaguchi A, Matsuda N. Ultrasonography-guided radial artery catheterization and further optimal sequences. J Clin Monit Comput. 2015 Feb;29(1):201-2. doi: 10.1007/s10877-014-9608-0. No abstract available.
  • 2013
    1. Shinjo H, Sato W, Imai E, Kosugi T, Hayashi H, Nishimura K, Nishiwaki K, Yuzawa Y, Matsuo S, Maruyama S. Comparison of kidney disease: improving global outcomes and acute kidney injury network criteria for assessing patients in intensive care units. Clin Exp Nephrol. 2014 Oct;18(5):737-45. doi: 10.1007/s10157-013-0915-4. Epub 2013 Nov 27.
    2. Adachi YU, Numaguchi A, Matsuda N. Not only bupivacaine but also propofol is sinking in lipid? J Anesth. 2014 Jun;28(3):476. doi: 10.1007/s00540-013-1725-2. Epub 2013 Oct 16. No abstract available.
    3. Adachi YU, Satomoto M, Higuchi H, Watanabe K. The determinants of propofol induction time in anesthesia. Korean J Anesthesiol. 2013 Aug;65(2):121-6. doi: 10.4097/kjae.2013.65.2.121. Epub 2013 Aug 27.
    4. Takata K, Adachi YU, Suzuki K, Obata Y, Sato S, Nishiwaki K. Dexmedetomidine-induced atrioventricular block followed by cardiac arrest during atrial pacing: a case report and review of the literature. J Anesth. 2014 Feb;28(1):116-20. doi: 10.1007/s00540-013-1676-7. Epub 2013 Aug 16. Review.
    5. Adachi YU, Hatano T, Hashimoto S, Ejima T, Murase K, Matsuda N. The advanced radial artery cannulation using Insyte-A邃「 with real-time ultrasound guidance. J Clin Monit Comput. 2013 Dec;27(6):703-4. doi: 10.1007/s10877-013-9482-1. Epub 2013 Jun 12. No abstract available.
    6. Murata T, Kubodera T, Ohbayashi M, Murase K, Adachi YU, Matsuda N. Recurarization after sugammadex following a prolonged rocuronium infusion for induced hypothermia. Can J Anaesth. 2013 May;60(5):508-9. doi: 10.1007/s12630-013-9909-7. Epub 2013 Mar 5. No abstract available.
    7. Adachi YU, Tanaka K, Suzuki S, Nishiwaki K, Matsuda N. Intravenous droperidol decreases the bispectral index during general anesthesia with sevoflurane and remifentanil. Masui. 2013 Jan;62(1):71-4. No abstract available.
    8. Kubodera T, Adachi YU, Hatano T, Ejima T, Numaguchi A, Matsuda N. Subcutaneous emphysema and ultrasound sonography. J Intensive Care. 2013 Nov 27;1(1):8. doi: 10.1186/2052-0492-1-8. eCollection 2013.
  • 2012
    1. Tanaka K, Adachi Y, Suzuki S, Nishiwaki K, Matsuda N. [ECG changes after the induction of general anesthesia with remifentanil: a report of three case]. Masui. 2012 Oct;61(10):1128-32. Japanese.
    2. Kimura-Kuroiwa K, Adachi YU, Mimuro S, Obata Y, Kawamata M, Sato S, Matsuda N. The effect of aging on dopamine release and metabolism during sevoflurane anesthesia in rat striatum: an in vivo microdialysis study. Brain Res Bull. 2012 Dec 1;89(5-6):223-30. doi: 10.1016/j.brainresbull.2012.08.006. Epub 2012 Sep 7.
    3. Adachi YU, Tuzuki M, Matsuda N. Is it constantly possible to penetrate only the anterior vessel wall against hydrostatic strain? Crit Care Med. 2012 Aug;40(8):2534-5; author reply 2535-6. doi: 10.1097/CCM.0b013e31825453ff. No abstract available.
    4. Adachi YU, Matsuda N. Epidural catheter insertion during general anesthesia. J Anesth. 2012 Aug;26(4):633. doi: 10.1007/s00540-012-1382-x. Epub 2012 May 17. No abstract available.
    5. Yamauchi-Satomoto M, Adachi YU, Kurita T, Morita K, Sato S. Cross-clamping of the descending thoracic aorta leads to the asymmetrical distribution of propofol during cardiopulmonary bypass surgery. Korean J Anesthesiol. 2012 Apr;62(4):327-31. doi: 10.4097/kjae.2012.62.4.327. Epub 2012 Apr 23.
    6. Kimura-Kuroiwa K, Adachi YU, Mimuro S, Kawamata M, Sato S, Matsuda N. Pentobarbital decreased nitric oxide release in the rat striatum but ketamine increased the release independent of cholinergic regulation. Exp Anim. 2012;61(2):165-70.
    7. Adachi YU, Matsuda N. Is it fluid or air causing anesthesia mumps? J Anesth. 2012 Aug;26(4):638-9. doi: 10.1007/s00540-012-1387-5. Epub 2012 Apr 18. No abstract available.
    8. Toriyama W, Adachi Y, Obata Y, Sato S, Matsuda N. [Sudden increases and decreases in bispectral index values more than 30 within 1 minute during general anesthesia]. Masui. 2012 Feb;61(2):210-3. Japanese.
    9. Kimura-Kuroiwa K, Adachi YU, Obata Y, Kawamata M, Sato S, Matsuda N. Dexmedetomidine and hydroxyzine synergistically potentiate the hypnotic activity of propofol in mice. J Anesth. 2012 Jun;26(3):422-8. doi: 10.1007/s00540-012-1344-3. Epub 2012 Feb 18.
  • 2011
    1. Toriyama W, Kurita T, Adachi Y, Suzuki Y, Obata Y, Sato S. [Pycnodysostosis: a case report]. Masui. 2011 Apr;60(4):496-8. Japanese.
    2. Miyazaki Y, Koike H, Akane A, Shibata Y, Nishiwaki K, Sobue G. Spinal cord stimulation markedly ameliorated refractory neuropathic pain in transthyretin Val30Met familial amyloid polyneuropathy. Amyloid. 2011 Jun;18(2):87-90. doi: 10.3109/13506129.2011.569782. Epub 2011 Apr 19.
    3. Matsuda N, Tsuzuki M, Ichikawa S, Tochikubo J, Tamura T, Adachi Y. [Inflammatory alert cell strategy in septic acute lung injury]. Nihon Yakurigaku Zasshi. 2011 Oct;138(4):151-4. Review. Japanese. No abstract available.
  • 2010
    1. Kawashima S, Itagaki T, Adachi Y, Ishii Y, Taniguchi M, Doi M, Sato S. [Inadvertent thoracic duct puncture during right axially central venous cannulation]. Masui. 2010 Oct;59(10):1298-300. Japanese.
    2. Mimuro S, Katoh T, Suzuki A, Yu S, Adachi YU, Uraoka M, Sano H, Sato S. Deterioration of myocardial injury due to dexmedetomidine administration after myocardial ischaemia. Resuscitation. 2010 Dec;81(12):1714-7. doi: 10.1016/j.resuscitation.2010.07.021. Epub 2010 Sep 15.
    3. Ema Y, Nishiwaki K. [Prevention of catheter-related bloodstream infections in the operation room]. Masui. 2010 May;59(5):577-84. Japanese.
    4. Adachi YU, Sato S. Four cases of inadvertent arterial cannulation despite of ultrasound guidance. Am J Emerg Med. 2010 May;28(4):533. doi: 10.1016/j.ajem.2010.03.029. No abstract available.
    5. Katoh H, Itagaki T, Suzuki K, Obata Y, Adachi Y, Doi M, Sato S. [Successful extubation in a patient with alacepril-induced tongue angioedema]. Masui. 2010 Apr;59(4):519-22. Japanese.
    6. Ohshima M, Hori E, Suzuki A, Katoh H, Itagaki T, Adachi Y, Doi M, Sato S. [Nasogastric tube syndrome suspected at the end of anesthesia]. Masui. 2010 Apr;59(4):495-7. Japanese.
    7. Kim B, Iwata K, Sugimoto K, Suzuki S, Ema Y, Tsunobuchi H, Nishiwaki K. Significance of prevention and early treatment of a postoperative twisted neck: atlantoaxial rotatory subluxation after head and neck surgery. J Anesth. 2010 Aug;24(4):598-602. doi: 10.1007/s00540-010-0932-3. Epub 2010 Mar 26.
  • 2009
    1. Itagaki T, Uchisaki S, Adachi Y, Suzuki K, Obata Y, Doi M, Sato S. [Apnea and severe respiratory depression induced by dexmedetomidine after general anesthesia in intensive care unit]. Masui. 2009 Dec;58(12):1534-7. Japanese.
    2. Adachi Y, Uchisaki S, Itagaki T, Suzuki K, Obata Y, Doi M, Sato S. [Serotonin syndrome caused by an overdose of dextromethorphan, Medicon]. Masui. 2009 Dec;58(12):1531-3. Japanese.
    3. Itagaki T, Katoh H, Adachi YU, Suzuki K, Obata Y, Doi M, Sato S. Hemothorax resulting from venous tearing by a catheter. J Anesth. 2009;23(4):636. doi: 10.1007/s00540-009-0811-y. Epub 2009 Nov 18. No abstract available.
    4. Adachi YU, Obata Y, Suzuki K, Katoh H, Itagaki T, Doi M, Sato S. Nafamostat prevents hypothermia and improves survival time after administration of lipopolysaccharide in a mouse surgical model. J Anesth. 2009;23(4):624-7. doi: 10.1007/s00540-009-0792-x. Epub 2009 Nov 18.
    5. Adachi Y, Itagaki T, Suzuki K, Uchisaki S, Kimura K, Obata Y, Doi M, Sato S. [Multiple difficulties for central venous access required the distal femoral vein catheterization: a case report]. Masui. 2009 Jul;58(7):913-6. Japanese.
    6. Adachi YU, Uchisaki S, Suzuki K, Itagaki T, Obata Y, Doi M, Sato S. Radial artery cannulation using the Insyte-A device with ultrasound assistance. J Anesth. 2009;23(2):304-5. doi: 10.1007/s00540-008-0715-2. Epub 2009 May 15. No abstract available.
    7. Adachi YU, Sato S. Intentional subdural anesthesia and the early onset of the block. Reg Anesth Pain Med. 2009 May-Jun;34(3):282-3. doi: 10.1097/AAP.0b013e31819a4f98. No abstract available.
    8. Kurimoto F, Saito K, Watanabe T, Nagatani T, Nishiwaki K, Wakabayashi T, Iwase S. Preliminary measurement of intraoperative sympathetic nerve activity using microneurography and laser Doppler flowmetry during surgical resection of suprasellar tumors. Neurol Med Chir (Tokyo). 2009 Jan;49(1):13-21.
  • 2008
    1. Adachi Y, Suzuki K, Itagaki T, Obata Y, Doi M, Sato S. [Two cases of anesthesia mumps in the upper parotid gland after general anesthesia in the lateral position]. Masui. 2008 Sep;57(9):1150-2. Japanese.
    2. Naruse S, Adachi Y, Takada K, Sano H, Suzuki K, Obata Y, Doi M, Sato S. [Severe arrhythmia after gastrectomy in patients with history of coronary bypass graft surgery using right gastroepiploic artery]. Masui. 2008 Sep;57(9):1147-9. Japanese.
    3. Adachi YU, Suzuki K, Itagaki T, Obata Y, Doi M, Sato S. A recommended solution for avoiding coring of a rubber stopper. Anesth Analg. 2008 Sep;107(3):1084; author reply 1084-5. doi: 10.1213/ane.0b013e31818259d6. No abstract available.
    4. Adachi YU, Suzuki K, Itagaki T, Obata Y, Doi M, Sato S. Radial artery cannulation using the Insyte-A holding the device in cigarette-style. J Anesth. 2008;22(3):331-2. doi: 10.1007/s00540-008-0618-2. Epub 2008 Aug 7. No abstract available.
    5. Adachi Y, Suzuki K, Obata Y, Doi M, Sato S. [Patient awakening from anesthesia was re-sedated by administration of flumazenil]. Masui. 2008 Jul;57(7):901-3. Japanese.
    6. Nao S, Adachi Y, Sato S. [Anesthesia for a patient with Cushing's disease and hepatitis B]. Masui. 2008 Jun;57(6):745-7. Japanese.
    7. Adachi Y, Mizuno K, Suzuki K, Obata Y, Doi M, Sato S. [Bispectral index decreased to "10" during propofol anesthesia despite the appropriate serum concentration of propofol]. Masui. 2008 Jun;57(6):728-30. Japanese.
  • 2007
    1. Satomoto M, Adachi YU, Sato S. Safe intubation with a gum-elastic bougie in a patient with Forestier's disease. J Anesth. 2007;21(4):519-20. Epub 2007 Nov 1. No abstract available.
    2. Iwakiri S, Adachi Y, Uchisaki S, Aoki Y, Nakagawa C, Katoh T, Igarashi H, Doi M, Sato S. [Case of facial edema and tongue swelling after aortic surgery in the lateral position]. Masui. 2007 Sep;56(9):1100-3. Japanese.
    3. Adachi Y, Suzuki K, Obata Y, Doi M, Sato S. [Electromyographic activity increases the bispectral index up to 98 during anesthesia]. Masui. 2007 Sep;56(9):1088-90. Japanese.
    4. Adachi YU, Yamada S, Satomoto M, Higuchi H, Watanabe K, Kazama T, Mimuro S, Sato S. Isoflurane anesthesia inhibits clozapine- and risperidone-induced dopamine release and anesthesia-induced changes in dopamine metabolism was modified by fluoxetine in the rat striatum: an in vivo microdialysis study. Neurochem Int. 2008 Feb;52(3):384-91. Epub 2007 Jul 22.
    5. Adachi YU, Sano H, Doi M, Sato S. Central neurogenic hyperventilation treated with intravenous fentanyl followed by transdermal application. J Anesth. 2007;21(3):417-9. Epub 2007 Aug 1.
    6. Adachi YU, Suzuki K, Obata Y, Doi M, Sato S. Is the hemodynamic response to nasotracheal fiberoptic bronchoscopy less than that following orotracheal bronchoscopy? Anesth Analg. 2007 Aug;105(2):543; author reply 543-4. No abstract available.
    7. Adachi YU, Nishino J, Suzuki K, Obata Y, Doi M, Sato S. Preemptive analgesia by preoperative administration of nonsteroidal anti-inflammatory drugs. J Anesth. 2007;21(2):294. Epub 2007 May 30. No abstract available.
    8. Adachi YU, Iwakiri S, Katoh T. Angioedema, angiotensin converting enzyme inhibitors, and angiotensin receptor blocking drugs. Can J Anaesth. 2007 Feb;54(2):155-7; author reply 157. No abstract available.
  • 2006
    1. Adachi Y, Higuchi H, Watanabe K, Kazama T, Doi M, Sato S. [The effect of halothane or sevoflurane anesthesia on the extracellular concentration of dopamine and its metabolites examined by in vivo microdialysis techniques]. Masui. 2006 Dec;55(12):1452-8. Japanese.
    2. Uchisaki S, Matsui G, Sato N, Nakajima Y, Adachi Y, Sano H, Doi M, Shiraishi Y, Sato S. [Ventricular fibrillation during induction of anesthesia in a patient with polycythemia vera]. Masui. 2006 Nov;55(11):1420-2. Japanese.
    3. Adachi YU, Sano H, Doi M, Sato S. Preemptive analgesia by nonsteroidal antiinflammatory drugs. Anesth Analg. 2006 Nov;103(5):1331-2; author reply 1332. No abstract available.
    4. Adachi YU, Sano H, Doi M, Sato S. Assessment and management of airway obstruction with tumors. J Clin Anesth. 2006 Sep;18(6):479. No abstract available.
    5. Adachi YU, Sanjo Y, Doi M, Sato S. Depth of the thoracic epidural space in 1776 patients using the paramedian approach. J Clin Anesth. 2006 Aug;18(5):396; author reply 396-7. No abstract available.
    6. Adachi YU, Doi M, Sato S. Cardiac arrest by venous air embolism during hepatic resection using the Cavitron Ultrasonic Surgical Aspirator. Anesth Analg. 2006 Aug;103(2):493-4; author reply 494. No abstract available.
    7. Shimada Y, Nishiwaki K, Sato K, Sato E, Miyasaka K. Pediatric anesthesia practice and training in Japan: a survey. Paediatr Anaesth. 2006 May;16(5):543-7.
    8. Adachi YU, Yamada S, Satomoto M, Watanabe K, Higuchi H, Kazama T, Doi M, Sato S. Pentobarbital inhibits L-DOPA-induced dopamine increases in the rat striatum: An in vivo microdialysis study. Brain Res Bull. 2006 May 15;69(5):593-6. Epub 2006 Mar 29.
    9. Adachi Y, Nakajima Y, Satomoto M, Morita K, Doi M, Sato S. [The heart rate variability in mice: telemetric evaluation of endotoxin shock]. Masui. 2006 Apr;55(4):436-40. Japanese.
    10. Adachi Y, Higuchi H, Watanabe K, Kazama T, Doi M, Sato S. [The effect of isoflurane anesthesia on dopamine release in rat striatum with pretreatment of imipramine]. Masui. 2006 Apr;55(4):412-8. Japanese.
    11. Adachi Y, Watanabe K, Satomoto M, Nakajima Y, Kazama T, Doi M, Sato S. [The effect of topical application of the local anesthetic (lidocaine) on the emergence from general anesthesia: the rat experimental model]. Masui. 2006 Feb;55(2):184-7. Japanese.
  • 2005
    1. Adachi YU, Yamada S, Satomoto M, Higuchi H, Watanabe K, Kazama T. Isoflurane anesthesia induces biphasic effect on dopamine release in the rat striatum. Brain Res Bull. 2005 Oct 15;67(3):176-81.
    2. Higuchi H, Adachi Y, Kazama T. The influence of lumbosacral cerebrospinal fluid volume on extent and duration of hyperbaric bupivacaine spinal anesthesia: a comparison between seated and lateral decubitus injection positions. Anesth Analg. 2005 Aug;101(2):555-60, table of contents.
    3. Higuchi H, Adachi Y, Kazama T. Effects of epidural saline injection on cerebrospinal fluid volume and velocity waveform: a magnetic resonance imaging study. Anesthesiology. 2005 Feb;102(2):285-92.
  • 2004
    1. Asano N, Taki K, Kondo T, Nishiwaki K, Kimura T, Shimada Y. [A case of spontaneous intracranial hypotension effectively treated with cervical epidural blood patch]. Masui. 2004 Oct;53(10):1185-8. Japanese.
    2. Kondo H, Feng GG, Nishiwaki K, Shimada Y, Hirokawa M, Komatsu T, Yokochi T, Ishikawa N. A role for L-glutamate ionotropic receptors in the development of rat neurogenic pulmonary edema. Eur J Pharmacol. 2004 Sep 24;499(3):257-63.
    3. Adachi YU, Satomoto M, Higuchi H. Tracheal intubation in the lateral position. Anesth Analg. 2004 Sep;99(3):952. No abstract available.
    4. Higuchi H, Adachi Y, Kazama T. Factors affecting the spread and duration of epidural anesthesia with ropivacaine. Anesthesiology. 2004 Aug;101(2):451-60.
    5. Higuchi H, Hirata J, Adachi Y, Kazama T. Influence of lumbosacral cerebrospinal fluid density, velocity, and volume on extent and duration of plain bupivacaine spinal anesthesia. Anesthesiology. 2004 Jan;100(1):106-14.

Research Keywords

Volatile anesthetics、Intracellular stress、Regional nerve block、Ultrasound sonography、Neuropathic pain、Migraine、Angiogenesis、Motor evoked potential、Post-operative delirium