Systems Neuropharmacology
KEYWORDS
- Emotion
- Stress
- Ineauity
- Claustrum
- ASD
- Imaging
- Brain-wide mapping
HEAD
LAB MEMBER
| Faculty |
Position |
Researchers |
| ZHOU Zhiwen |
Assistant Professor |
Researchers |
CONTACT
| Email |
kasai.atsushi◎riem.nagoya-u.ac.jp (Please send a message after replacing "◎" mark with "@" mark. ) |
| HP |
Private Page |
OUTLINE
Our laboratory aims to elucidate the complex neural mechanisms underlying emotional behavior and to advance the understanding of psychiatric disorders and the development of therapeutic strategies. We study socio-emotional functions such as anxiety-related responses, vigilance behaviors, and inequity aversion using mouse models. To this end, we integrate brain-wide activity and circuit mapping, in vivo calcium imaging, multi-bundle imaging, and optogenetic and chemogenetic approaches, and analyze brain network dynamics across multiple levels.
RESEARCH PROJECTS
- Pathophysiological mechanisms of stress-related psychiatric disorders
- Neural mechanisms underlying vigilance and inequity aversion
- Elucidating the pathophysiological mechanisms of neurodevelopmental disorders
- Mechanisms and therapeutic applications of transcranial magnetic stimulation–based brain interventions
BIBLIOGRAPHY
2025
- Dewa KI et al, The astrocytic ensemble is a multiday eligibility trace for memory stabilization. Nature, 648:146-156, 2025.
- Ueno H et al, Recovery of centralities in medial prefrontal and sensory-related cortices associated with social behavior improvements in an autism mouse model. Sci Rep 15:22895, 2025.
2024
- Yokoyama R et al, (R)-ketamine restores anterior insular cortex activity and cognitive deficits in social isolation-reared mice. Molecular Psychiatry 29:1406-1416, 2024.
2022
- Endo F et al, Molecular basis of astrocyte diversity and morphology across the CNS in health and disease. Science 378(6619):eadc9020, 2022.
- Niu M et al. Claustrum mediates bidirectional and reversible control of stress-induced anxiety responses. Science Advances 8(11):eabi6375, 2022.
2020
- Tanuma M et al, Direct visualization of an antidepressant analog using surface-enhanced Raman scattering in the brain. JCI Insight 5:e133348, 2020.
2019
- Seiriki K et al, Whole-brain block-face serial microscopy tomography at subcellular resolution using FAST. Nature Protocols 14:1509-1529, 2019.
2017
- Seiriki K et al, High-speed imaging and scalable whole-brain imaging in rodents and primates. Neuron 94:1085-1100, 2017.
